Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HOXD1 Gene

protein-coding   GIFtS: 52
GCID: GC02P177053

Homeobox D1

(Previous name: homeo box D1)
(Previous symbols: HOX4, HOX4G)
  Search for HOXD1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Homeobox D11 2     Homeobox Protein Hox-GG2 3
HOX4G1 2 3 5     Hox-4.72
HOX41 2 3     Homeo Box 4G2
Homeo Box D11 2     Homeobox Protein Hox-D12

External Ids:    HGNC: 51321   Entrez Gene: 32312   Ensembl: ENSG000001286457   OMIM: 1429875   UniProtKB: Q9GZZ03   

Export aliases for HOXD1 gene to outside databases

Previous GC identifers: GC02P175105 GC02P175714 GC02P177017 GC02P177255 GC02P176878 GC02P176761 GC02P168930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HOXD1 Gene:
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. This
nuclear protein functions as a sequence-specific transcription factor that is involved in differentiation and
limb development. Mutations in this gene have been associated with severe developmental defects on the
anterior-posterior (a-p) limb axis. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXD1 Gene:
HOXD1 (homeobox D1) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXD1_HUMAN, Q9GZZ0
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures

Gene Wiki entry for HOXD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXD1 gene promoter:
         AhR   Sox5   FOXF2   AP-4   Arnt   POU2F1   POU2F1a   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXD1 promoter sequence
   Search Chromatin IP Primers for HOXD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q31.1   Ensembl cytogenetic band:  2q31.1   HGNC cytogenetic band: 2q31.1

HOXD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXD1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P177053:  view genomic region     (about GC identifiers)

Start:
177,053,307 bp from pter      End:
177,055,688 bp from pter
Size:
2,382 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HXD1_HUMAN, Q9GZZ0 (See protein sequence)
Recommended Name: Homeobox protein Hox-D1  
Size: 328 amino acids; 34093 Da
Secondary accessions: B2RAB4

Explore the universe of human proteins at neXtProt for HOXD1: NX_Q9GZZ0

Explore proteomics data for HOXD1 at MOPED


See HOXD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_078777.1  
ENSEMBL proteins: 
 ENSP00000328598  

HOXD1 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for HOXD1
OriGene Custom MassSpec
OriGene Custom Protein Services for HOXD1
GenScript Custom Purified and Recombinant Proteins Services for HOXD1
Novus Biologicals HOXD1 Proteins
Novus Biologicals HOXD1 Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for HOXD1

 
Search eBioscience for Proteins for HOXD1 

HOXD1 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for HOXD1
Novus Biologicals HOXD1 Antibodies
Abcam antibodies for HOXD1
Cloud-Clone Corp. Antibodies for HOXD1
Search ThermoFisher Antibodies for HOXD1
LSBio Antibodies in human, mouse, rat for HOXD1

HOXD1 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for HOXD1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HOXD1
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HOXD1
Cloud-Clone Corp. CLIAs for HOXD1
Search eBioscience for ELISAs for HOXD1 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9GZZ0

ProtoNet protein and cluster: Q9GZZ0

1 Blocks protein domain: IPB001827 Homeobox protein

UniProtKB/Swiss-Prot: HXD1_HUMAN, Q9GZZ0
Similarity: Belongs to the Antp homeobox family. Labial subfamily
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with HOXD1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HXD1_HUMAN, Q9GZZ0
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures

     Genatlas biochemistry entry for HOXD1:
homeo box D1(4G),homologous to mouse Hox-4.9,Drosophila lab

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with HOXD1           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for HOXD1:
 Increased G2M DNA content  Synthetic lethal with Ras 

     5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxd1):
 behavior/neurological  craniofacial  integument  nervous system  skeleton 

Find genes that share phenotypes with HOXD1           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Hoxd1tm1Mrc for HOXD1

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXD1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXD1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXD1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXD1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat HOXD1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HOXD1 (see all 37):
hsa-let-7d hsa-miR-503 hsa-miR-301a hsa-miR-508-3p hsa-let-7g hsa-miR-9 hsa-let-7a hsa-miR-133a
SwitchGear 3'UTR luciferase reporter plasmidHOXD1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HOXD1
Predesigned siRNA for gene silencing in human, mouse, rat HOXD1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HOXD1

Clone
Products:
     
OriGene clones in human, mouse for HOXD1 (see all 7)
OriGene ORF clones in mouse, rat for HOXD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXD1 (NM_024501)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD1

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for HOXD1
Browse ESI BIO Cell Lines and PureStem Progenitors for HOXD1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
HXD1_HUMAN, Q9GZZ0: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

Find genes that share ontologies with HOXD1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXD1: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for HOXD1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for HOXD1 (Q9GZZ03 ENSP000003285984) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
HOXC9P312743, ENSP000003028364I2D: score=1 STRING: ENSP00000302836
About this table

Gene Ontology (GO): 5 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0019233sensory perception of pain IEA--
GO:0030182neuron differentiation IEA--
GO:0048706embryonic skeletal system development IEA--

Find genes that share ontologies with HOXD1           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HOXD1 (HXD1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for HOXD1 gene: 
NM_024501.2  

Unigene Cluster for HOXD1:

Homeobox D1
Hs.83465  [show with all ESTs]
Unigene Representative Sequence: AF241528
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000331462(uc002ukv.4 uc010fqy.3 uc021vsr.1)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HOXD1 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HOXD1 (see all 37):
hsa-let-7d hsa-miR-503 hsa-miR-301a hsa-miR-508-3p hsa-let-7g hsa-miR-9 hsa-let-7a hsa-miR-133a
SwitchGear 3'UTR luciferase reporter plasmidHOXD1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HOXD1
Predesigned siRNA for gene silencing in human, mouse, rat HOXD1
Clone
Products:
     
OriGene clones in human, mouse for HOXD1 (see all 7)
OriGene ORF clones in mouse, rat for HOXD1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXD1 (NM_024501)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXD1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HOXD1
OriGene qSTAR qPCR primer pairs in human, mouse for HOXD1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD1
  QuantiTect SYBR Green Assays in human, mouse, rat HOXD1
  QuantiFast Probe-based Assays in human, mouse, rat HOXD1

Additional mRNA sequence: 

AF241528.1 AK314120.1 BC014477.1 BC028190.1 

2 DOTS entries:

DT.110725  DT.100748178 

Selected AceView cDNA sequences (see all 44):

AI088005 NM_024501 BC014477 AW137557 BQ687080 AI640538 AW073903 AF241528 
BX101877 AI479390 BC028190 BF062946 N68975 W68537 W68536 AW300533 
AW001001 AW051981 BF439323 AW205452 AW135647 BG766603 BE464233 BU145213 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for HOXD1    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3
SP1:                        
SP2:              -         


ECgene alternative splicing isoforms for HOXD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

HOXD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAAAGGGTTT
HOXD1 Expression
About this image


HOXD1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
         Mononuclear Myocytes Hyoid Arch Muscles
 
 Kidney (Urinary System)    fully expand to see all 2 entries
         Ureteric Bud Cells Ureteric Bud
HOXD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HOXD1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.83465
    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXD1: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for HOXD1
OriGene qSTAR qPCR primer pairs in human, mouse for HOXD1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD1
QuantiTect SYBR Green Assays in human, mouse, rat HOXD1
QuantiFast Probe-based Assays in human, mouse, rat HOXD1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for HOXD1 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hoxd11 , 5 homeobox D11, 5 81.95(n)1
83.38(a)1
  2 (44.13 cM)5
154291  NM_010467.21  NP_034597.21 
 747629805 
lizard
(Anolis carolinensis)
Reptilia HOXD16
homeobox D1
34(a)
1 ↔ 1
2(71782318-71798885)
tropical clawed frog
(Xenopus tropicalis)
Amphibia hoxd11 homeobox D1 59.59(n)
56.12(a)
  549432  NM_001016678.2  NP_001016678.1 
zebrafish
(Danio rerio)
Actinopterygii hoxc1a6
homeo box C1a
29(a)
1 ↔ 1
23(36229648-36242532) ENSDARG00000070337
fruit fly
(Drosophila melanogaster)
Insecta lab6
labial
15(a)
1 ↔ 1
3R(2487149-2504312)
worm
(Caenorhabditis elegans)
Secernentea ceh-136
Protein CEH-13 (ceh-13) mRNA, complete cds
31(a)
1 ↔ 1
III(7555660-7558208) WBGene00000437


ENSEMBL Gene Tree for HOXD1 (if available)
TreeFam Gene Tree for HOXD1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for HOXD1 gene
GSX12  HOXA32  MEOX12  EVX22  HOXA12  HOXB12  HOXB32  HOXA22  
GSX22  EVX12  HOXB22  MEOX22  PDX12  HOXD32  
2 SIMAP similar genes for HOXD1 using alignment to 3 protein entries:     HXD1_HUMAN (see all proteins):
HOX B6    HMX2

Find genes that share paralogs with HOXD1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for HOXD1 (see all 11)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1126052551,2
C--177055751(+) ATAAC-/T/TT  
        
TTTTT
1 -- ds50011CSA 2
rs1388303061,2
--177055931(+) TTTTTA/GGTAGA 1 -- ds50010--------
rs1896741201,2
--177055949(+) TTTCAC/TCATGT 1 -- ds50010--------
rs1830531591,2
--177055994(+) GATCCA/GCCCAC 1 -- ds50010--------
rs1418398001,2
--177056020(+) TGCTAG/TAATTA 1 -- ds50010--------
rs1881278751,2
C--177056051(+) CAGCCA/GATAAC 1 -- ds50010--------
rs1446491321,2
--177056059(+) AACTTC/TTAAAA 1 -- ds50010--------
rs1484824031,2
--177056094(+) CACACC/TCAGCA 1 -- ds50010--------
rs67101421,2,4
----see VAR_0340032 mis40--------
rs3681677991,2
----177056074(+) TACTTC/TTACAG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for HOXD1 (177053307 - 177055688 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for HOXD1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv875438CNV Loss21882294
dgv676n67CNV Gain20364138

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HOXD1
DNA2.0 Custom Variant and Variant Library Synthesis for HOXD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 142987    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for HOXD1:
Syndactyly

Find genes that share disorders with HOXD1           About GenesLikeMe

Genetic Association Database (GAD): HOXD1
Human Genome Epidemiology (HuGE) Navigator: HOXD1 (4 documents)

Export disorders for HOXD1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for HOXD1 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with HOXD1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PubMed id 20852632)1, 4 Goode E.L....Pharoah P.D. (Nat. Genet. 2010)
  2. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
  3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
  4. Isolation and characterization of the human homeobox gene HOX D1. (PubMed id 11455954)1, 2 Appukuttan B.... Stout J.T. (Mol. Biol. Rep. 2000)
  5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
  6. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
  7. Interleukin-27 treated human macrophages induce the expression of novel microRNAs which may mediate anti-viral properties. (PubMed id 23535375)1 Swaminathan S....Imamichi T. (Biochem. Biophys. Res. Commun. 2013)
  8. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. (PubMed id 22930747)1 Faryna M....Gerhauser C. (FASEB J. 2012)
  9. Homeobox D1 regulates angiogenic functions of endothelial cells via integrin I^1 expression. (PubMed id 21501586)1 Park H....Kwon Y.G. (Biochem. Biophys. Res. Commun. 2011)
  10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 3231 HGNC: 5132 AceView: HOXD1 Ensembl:ENSG00000128645 euGenes: HUgn3231
ECgene: HOXD1 H-InvDB: HOXD1

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for HOXD1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for HOXD1 gene:
Search GeneIP for patents involving HOXD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HOXD1  
 OriGene qPCR primer pairs and template standards for HOXD1   OriGene Protein Over-expression Lysate for HOXD1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for HOXD1  
 OriGene qSTAR qPCR primer pairs in human, mouse for HOXD1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for HOXD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for HOXD1   OriGene Custom Protein Services for HOXD1  

 
 
 Block miRNA regulation of human, mouse, rat HOXD1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HOXD1
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXD1 Predesigned siRNA for gene silencing in human, mouse, rat HOXD1
 QuantiFast Probe-based Assays in human, mouse, rat HOXD1 QuantiTect SYBR Green Assays in human, mouse, rat HOXD1
 PCR Arrays including human, mouse, rat HOXD1 Search Chromatin IP Primers for HOXD1
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXD1  Search GeneGlobe Interaction Network for HOXD1
 Regulatory tfbs in HOXD1 promoter
 GenScript Custom Purified and Recombinant Proteins Services for HOXD1 GenScript cDNA clones with any tag delivered in your preferred vector for HOXD1
 GenScript Custom Assay Services for HOXD1 GenScript Custom overexpressing Cell Line Services for HOXD1
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for HOXD1 (HXD1)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 HOXD1 antibodies
 HOXD1 proteins
 HOXD1 lysates
 Antibodies for HOXD1
 See all of Abcam's Antibodies, Kits and Proteins for HOXD1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for HOXD1
 Antibodies for HOXD1
 ELISAs for HOXD1
 CLIAs for HOXD1



 Browse ESI BIO Cell Lines and PureStem Progenitors for HOXD1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXD1
 SwitchGear 3'UTR luciferase reporter plasmids for HOXD1
 SwitchGear Promoter luciferase reporter plasmids for HOXD1
 Search ThermoFisher Antibodies for HOXD1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXD1
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXD1
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXD1
 LSBio Antibodies in human, mouse, rat for HOXD1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
 Search Addgene for plasmids for HOXD1
  Search eBioscience for proteins for HOXD1
  Search eBioscience for elisas for HOXD1
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      HOXD1 gene at Home site.
Version: 3.12.212 17 Sep 2014
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4