Aliases for HOXC9 Gene
Aliases for HOXC9 Gene
External Ids for HOXC9 Gene
- HGNC: 5130
- Entrez Gene: 3225
- Ensembl: ENSG00000180806
- OMIM: 142971
- UniProtKB: P31274
Previous HGNC Symbols for HOXC9 Gene
- HOX3
- HOX3B
Previous GeneCards Identifiers for HOXC9 Gene
- GC12M054413
- GC12P054506
- GC12P054110
- GC12P052680
- GC12P054393
- GC12P054388
- GC12P051432
- GC12P053995
- GC12P053998
- GC12P054013
- GC12P054042
- GC12P054053
Summaries for HOXC9 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXC9 Gene
HOXC9 (Homeobox C9) is a Protein Coding gene. Among its related pathways are Differentiation of white and brown adipocyte. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD9.
UniProtKB/Swiss-Prot for HOXC9 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC9 Gene
Genomics for HOXC9 Gene
Regulatory Elements for HOXC9 Gene
- Transcription factor binding sites by QIAGEN in the HOXC9 gene promoter:
Regulatory Element Products
Genomic Location for HOXC9 Gene
- Chromosome:
- 12
- Start:
- 53,994,895 bp from pter
- End:
- 54,003,337 bp from pter
- Size:
- 8,443 bases
- Orientation:
- Plus strand
Genomic View for HOXC9 Gene
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXC9 Gene
Proteins for HOXC9 Gene
-
Protein details for HOXC9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31274-HXC9_HUMAN
- Recommended name:
- Homeobox protein Hox-C9
- Protein Accession:
- P31274
- B2RCN7
- Q9H1I0
Protein attributes for HOXC9 Gene
- Size:
- 260 amino acids
- Molecular mass:
- 29248 Da
- Quaternary structure:
-
- Interacts with Geminin/GMNN, which inhibits transcriptional activity.
Protein Expression for HOXC9 Gene
Post-translational modifications for HOXC9 Gene
Other Protein References for HOXC9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXC9
-
Abcam antibodies for HOXC9
- Invitrogen Antibodies for HOXC9
- antibodies-online Antibodies for HOXC9: See all 54
- Search GeneTex for Antibodies for HOXC9
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXC9
Protein Products
-
OriGene Purified Proteins for HOXC9
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXC9
- Origene Custom Protein Services for HOXC9
- antibodies-online Proteins for HOXC9: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXC9
-
Abcam proteins for HOXC9
Assay Products
No data available for DME Specific Peptides for HOXC9 Gene
Domains & Families for HOXC9 Gene
Gene Families for HOXC9 Gene
Protein Domains for HOXC9 Gene
Suggested Antigen Peptide Sequences for HOXC9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31274- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXC9 Gene
Molecular function for HOXC9 Gene
- GENATLAS Biochemistry:
- homeo box C9(3B),homologous to mouse Hox-3.2,Drosophila abd-B,involved in mouse posterior limb patterning,expressed in posterior limb
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXC9 Gene
- MGI mutant phenotypes for HOXC9:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HOXC9:
-
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability in esophageal squamous lineage
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Strongly decreased CFP-tsO45G cell surface transport
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Synthetic lethal with vaccinia virus (VACV) infection
- Negative genetic interaction between BLM-/- and BLM+/+
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXC9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC9 gene
- Search ViGene Biosciences for HOXC9
CRISPR Products
-
OriGene CRISPR knockouts for HOXC9
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC9
- GenScript: Design CRISPR guide RNA sequences for HOXC9
miRNA for HOXC9 Gene
- miRTarBase miRNAs that target HOXC9
Targeted motifs for HOXC9 Gene
- Consensus sequence: GGCCATAAATCA Submotif: canonical Cell Type: Ainv15 GEO ID: GSE21812
miRNA Products
- Search ViGene Biosciences for HOXC9
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXC9
- Browse OriGene Inhibitory RNA Products For HOXC9
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC9 gene
Clone Products
-
OriGene ORF clones in human for HOXC9
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HOXC9
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXC9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXC9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC9 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HOXC9 Gene
Localization for HOXC9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXC9 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0016235 | aggresome | IDA | -- |
Pathways & Interactions for HOXC9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Differentiation of white and brown adipocyte | ||
Pathways by source for HOXC9 Gene
1 BioSystems pathway for HOXC9 Gene
Interacting Proteins for HOXC9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
| GO:0048704 | embryonic skeletal system morphogenesis | IEA | -- |
No data available for SIGNOR curated interactions for HOXC9 Gene
Transcripts for HOXC9 Gene
mRNA/cDNA for HOXC9 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (51) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXC9
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC9
- GenScript: Design CRISPR guide RNA sequences for HOXC9
miRNA Products
- Search ViGene Biosciences for HOXC9
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXC9
- Browse OriGene Inhibitory RNA Products For HOXC9
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC9 gene
Clone Products
-
OriGene ORF clones in human for HOXC9
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HOXC9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Subcutaneous White Adipocytes Subcutaneous White Adipose
- Subcutaneous White Adipocytes Cranial Subcutaneous White Adipose
- Subcutaneous White Adipocytes Facial Subcutaneous White Adipose
- Brown-like Adipocyte Cells Subcutaneous White Adipose
- Subcutaneous White Adipocytes Body Subcutaneous White Adipose
-
Bone (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- Kidney (Urinary System)
-
Spinal Cord (Nervous System)
- Preganglionic Motor Neurons Preganglionic Column
-
Neurons
- Preganglionic Motor Neurons Preganglionic Column
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Somite (Muscoskeletal System)
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HOXC9 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXC9 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXC9 Gene:
HOXC9SOURCE GeneReport for Unigene cluster for HOXC9 Gene:
Hs.658823Evidence on tissue expression from TISSUES for HOXC9 Gene
- Eye(4)
Primer Products
-
OriGene qPCR primer pairs for HOXC9
-
OriGene qPCR primer pairs and template standards for HOXC9
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC9 Gene
Orthologs for HOXC9 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXC9 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXC9 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxc9 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxc9 34 |
|
||
| dog (Canis familiaris) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | HOXC9 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXC9 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC101733557 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxc9a 35 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXC9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXC9 Gene
Paralogs for HOXC9 Gene
(9) SIMAP similar genes for HOXC9 Gene using alignment to 3 proteins:
Variants for HOXC9 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036267 | A colorectal cancer sample | ||||
| rs1000377526 | -- | 54,000,843(+) | CGAGG(A/G)GGCGA | intron-variant, upstream-variant-2KB | |
| rs1000467328 | -- | 54,002,349(+) | AGCCT(A/G)GCTAA | intron-variant | |
| rs1001251239 | -- | 53,999,595(+) | ACGCA(C/T)TTTTA | intron-variant, upstream-variant-2KB | |
| rs1001286191 | -- | 53,999,315(+) | TAAAG(G/T)CGCCT | intron-variant, upstream-variant-2KB |
Relevant External Links for HOXC9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXC9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC9 Gene
Disorders for HOXC9 Gene
Relevant External Links for HOXC9
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HOXC9
No disorders were found for HOXC9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC9 Gene
Publications for HOXC9 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 64
- Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3 64
- Organization of human class I homeobox genes. (PMID: 2576652) Boncinelli E. … Simeone A. (Genome 1989) 3 4 64
Products for HOXC9 Gene
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- OriGene qPCR primer pairs and template standards for HOXC9
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- Novus Biologicals Antibodies for HOXC9
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- Novus Biologicals
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- Abcam antibodies for HOXC9
- Abcam proteins for HOXC9
- Search for Assays for HOXC9 at Abcam
- Find your target
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- antibodies-online Antibodies for HOXC9: See all 54
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXC9 gene
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- VectorBuilder custom plasmid, inducible vectors for HOXC9
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- Mammalian expression: PiggyBac
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXC9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (141) ENCODE
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- (143) Horizon
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- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




