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HOXC9 Gene

protein-coding   GIFtS: 50
GCID: GC12P054388

Homeobox C9

(Previous name: homeo box C9)
(Previous symbols: HOX3, HOX3B)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox C91 2
HOX3B1 2 3 5
HOX31 2
Homeo Box C91 2
Homeobox Protein Hox-3B2 3
Homeobox Protein Hox-C92

External Ids:    HGNC: 51301   Entrez Gene: 32252   Ensembl: ENSG000001808067   OMIM: 1429715   UniProtKB: P312743   

Export aliases for HOXC9 gene to outside databases

Previous GC identifers: GC12M054413 GC12P054506 GC12P054110 GC12P052680 GC12P054393 GC12P051432


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXC9 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes
located in a cluster on chromosome 12. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXC9 Gene:
HOXC9 (homeobox C9) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot: HXC9_HUMAN, P31274
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXC9 gene promoter:
         RORalpha1   E2F-5   Sp1   Hand1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXC9 promoter sequence
   Search Chromatin IP Primers for HOXC9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXC9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC9 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054388:  view genomic region     (about GC identifiers)

Start:
54,388,679 bp from pter      End:
54,397,121 bp from pter
Size:
8,443 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXC9_HUMAN, P31274 (See protein sequence)
Recommended Name: Homeobox protein Hox-C9  
Size: 260 amino acids; 29248 Da
Subunit: Interacts with Geminin/GMNN, which inhibits transcriptional activity
1 PDB 3D structure from and Proteopedia for HOXC9:
2LP0 (3D)    
Secondary accessions: B2RCN7 Q9H1I0

Explore the universe of human proteins at neXtProt for HOXC9: NX_P31274

Explore proteomics data for HOXC9 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXC9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008828.1  
    ENSEMBL proteins: 
     ENSP00000423861   ENSP00000302836  

    HOXC9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HOXC9

     
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    LSBio Antibodies in human, mouse, rat for HOXC9

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    Cloud-Clone Corp. ELISAs for HOXC9
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    Search eBioscience for ELISAs for HOXC9 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR020479 Homeobox_metazoa
     IPR006711 Hox9_activation_N
     IPR017112 Homeobox_Hox9
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry P31274

    ProtoNet protein and cluster: P31274

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB006711 Hox9 activation region


    UniProtKB/Swiss-Prot: HXC9_HUMAN, P31274
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with HOXC9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXC9_HUMAN, P31274
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXC9:
    homeo box C9(3B),homologous to mouse Hox-3.2,Drosophila abd-B,involved in mouse posterior limb
    patterning,expressed in posterior limb

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with HOXC9           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxc9):
     growth/size/body  limbs/digits/tail  skeleton 

    Find genes that share phenotypes with HOXC9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HOXC9: Hoxc9tm1Hsu Hoxc9tm1Mrc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXC9
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXC9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXC9

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  GGCCATAAATCA 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXC9:
    hsa-mir-124-3p (MIRT023072)

    Block miRNA regulation of human, mouse, rat HOXC9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC9 (see all 33):
    hsa-miR-21* hsa-miR-3164 hsa-miR-193a-3p hsa-miR-200a hsa-let-7a-2* hsa-miR-141 hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidHOXC9 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXC9
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC9

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for HOXC9

    Clone
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    OriGene clones in human, mouse for HOXC9 (see all 5)
    OriGene ORF clones in mouse, rat for HOXC9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXC9 (NM_006897)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC9

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    Browse ESI BIO Cell Lines and PureStem Progenitors for HOXC9 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXC9_HUMAN, P31274: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with HOXC9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXC9: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXC9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HOXC9 (P312743 ENSP000003028364) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    HOXD9P283563, ENSP000002494994I2D: score=1 STRING: ENSP00000249499
    IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
    NMIQ132873, ENSP000002433464I2D: score=1 STRING: ENSP00000243346
    PCGF2P352273, ENSP000003540334I2D: score=1 STRING: ENSP00000354033
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0048704embryonic skeletal system morphogenesis IEA--
    GO:0048706embryonic skeletal system development ----

    Find genes that share ontologies with HOXC9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXC9 (HXC9)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOXC9 gene: 
    NM_006897.1  

    Unigene Cluster for HOXC9:

    Homeobox C9
    Hs.658823  [show with all ESTs]
    Unigene Representative Sequence: NM_006897
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504557 ENST00000508190 ENST00000303450(uc001seq.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXC9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC9 (see all 33):
    hsa-miR-21* hsa-miR-3164 hsa-miR-193a-3p hsa-miR-200a hsa-let-7a-2* hsa-miR-141 hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidHOXC9 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXC9
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC9
    Clone
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    OriGene clones in human, mouse for HOXC9 (see all 5)
    OriGene ORF clones in mouse, rat for HOXC9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXC9 (NM_006897)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC9
    Primer
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    OriGene qPCR primer pairs and template standards for HOXC9
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXC9
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat HOXC9
      QuantiTect SYBR Green Assays in human, mouse, rat HOXC9
      QuantiFast Probe-based Assays in human, mouse, rat HOXC9

    Additional mRNA sequence: 

    AK000445.1 AK315194.1 BC021265.1 BC032769.1 BC053894.1 

    3 DOTS entries:

    DT.99957565  DT.208892  DT.99935637 

    Selected AceView cDNA sequences (see all 51):

    X99682 CR600750 CR617045 NM_006897 AI361560 AL556826 CA411875 AI085613 
    AA227856 BC032769 AI953122 AI522164 BE786336 AK000445 BQ772563 CB125288 
    BU621618 BU616567 AI934382 AI949325 CA429963 AI580182 AA719162 BU625573 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXC9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACGGCTCGC
    HOXC9 Expression
    About this image


    HOXC9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 6 entries
             Subcutaneous White Adipocytes Cranial Subcutaneous White Adipose
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Renal Vesicle
             mK3
     
     Bone (Muscoskeletal System)
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
     
     Neurons
             Preganglionic Motor Neurons Preganglionic Column
             Lateral motor column neuron-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Preganglionic Motor Neurons Preganglionic Column
             Lateral motor column neuron-like cells
    HOXC9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXC9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658823
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXC9: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for HOXC9
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    QuantiFast Probe-based Assays in human, mouse, rat HOXC9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HOXC9 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxc91 , 5 homeobox C91, 5 96.03(n)1
    99.62(a)1
      15 (58.04 cM)5
    154271  NM_008272.31  NP_032298.11 
     1029764395 
    chicken
    (Gallus gallus)
    Aves HOXC91 homeobox C9 75.93(n)
    84.17(a)
      425723  NM_001277282.1  NP_001264211.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXC96
    homeobox C9
    90(a)
    1 ↔ 1
    2(72063430-72065916)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017335571 homeobox protein Hox-C9-like 74.9(n)
    84.17(a)
      101733557  XM_004911933.1  XP_004911990.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxc9a2 homeo box C9a 77.69(n)   58043  NM_131528.1 


    ENSEMBL Gene Tree for HOXC9 (if available)
    TreeFam Gene Tree for HOXC9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXC9 gene
    HOXD112  ENSG000002571842  HOXD102  HOXC132  HOXC102  HOXD122  HOXA92  HOXA132  
    HOXB132  HOXC122  HOXC112  HOXD132  HOXA112  HOXB92  HOXD92  HOXA102  
    9 SIMAP similar genes for HOXC9 using alignment to 3 protein entries:     HXC9_HUMAN (see all proteins):
    HOX B6    HOXB1    HOXA-9    HOXA9    HOXB9    HOXA6
    HOXD9    HOXC10    HOXD8

    Find genes that share paralogs with HOXC9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXC9 (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362674
    A colorectal cancer sample4--see VAR_0362672 G S mis40--------
    rs1920860091,2
    --54392122(+) CTTTCC/TTCCCC 1 -- us2k10--------
    rs1130504911,2
    C,F--54392170(+) TCTCCT/ACCCCA 1 -- us2k11Minor allele frequency- A:0.00CSA 1
    rs22419381,2
    C,F,H--54392449(-) GTGAAA/GCCCCC 1 -- us2k110Minor allele frequency- G:0.16EA NS WA NA 2274
    rs1841337621,2
    --54392495(+) TGCCCC/TCTCTT 1 -- us2k10--------
    rs1869516491,2
    --54392529(+) TACTTA/GACTAA 1 -- us2k10--------
    rs1150664151,2
    C,F--54392540(+) AGCCCC/TCCTTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1431887021,2
    --54392739(+) CGTTGC/TTTTTT 1 -- us2k10--------
    rs733131791,2
    C,F--54392816(+) CTCATA/TAAAAT 1 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1150061651,2
    F--54393338(+) GCTGCT/ACCTGA 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for HOXC9 (54388679 - 54397121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for HOXC9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv899102CNV Loss21882294
    nsv899101CNV Loss21882294
    nsv899100CNV Loss21882294
    nsv826379CNV Gain20364138
    nsv428282CNV Gain18775914
    dgv512e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXC9
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142971    OMIM disorders: --


    Find genes that share disorders with HOXC9           About GenesLikeMe


    Export disorders for HOXC9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXC9 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with HOXC9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (Teratology 2002)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    5. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
    6. Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma. (PubMed id 23579273)1 Kocak H....Fischer M. (amp 2013)
    7. Homeobox C9 is not potentially related to congenital heart disease in Chinese patients. (PubMed id 22106857)1 Sun L....Ma X. (Genet Test Mol Biomarkers 2012)
    8. Structural basis for homeodomain recognition by the cell-cycle regulator Geminin. (PubMed id 22615398)2 Zhou B.... Zhu G. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastoma. (PubMed id 21507931)1 Mao L....Ding H.F. (Cancer Res. 2011)
    10. The transcription factor HOXC9 regulates endothelial cell quiescence and vascular morphogenesis in zebrafish via inhibition of interleukin 8. (PubMed id 21493894)1 Stoll S.J....Kroll J. (Circ. Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3225 HGNC: 5130 AceView: HOXC9 Ensembl:ENSG00000180806 euGenes: HUgn3225
    ECgene: HOXC9 H-InvDB: HOXC9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXC9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXC9 gene:
    Search GeneIP for patents involving HOXC9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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