Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HOXC8 Gene

protein-coding   GIFtS: 50
GCID: GC12P054402

Homeobox C8

(Previous name: homeo box C8)
(Previous symbols: HOX3, HOX3A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Homeobox C81 2     Homeobox Protein Hox-3A2 3
HOX3A1 2 3 5     Homeo Box 3A2
HOX31 2     Homeobox Protein Hox-C82
Homeo Box C81 2     Hox-3.1, Mouse, Homolog Of2

External Ids:    HGNC: 51291   Entrez Gene: 32242   Ensembl: ENSG000000379657   OMIM: 1429705   UniProtKB: P312733   

Export aliases for HOXC8 gene to outside databases

Previous GC identifers: GC12M054416 GC12P054515 GC12P054119 GC12P052689 GC12P051440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HOXC8 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes
located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage
differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. (provided by
RefSeq, Jul 2008)

GeneCards Summary for HOXC8 Gene:
HOXC8 (homeobox C8) is a protein-coding gene. Diseases associated with HOXC8 include pancreatic ductal adenocarcinoma, and chondrodysplasia. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXC8 gene promoter:
         Sp1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXC8 promoter sequence
   Search Chromatin IP Primers for HOXC8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054402:  view genomic region     (about GC identifiers)

Start:
54,402,832 bp from pter      End:
54,407,570 bp from pter
Size:
4,739 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273 (See protein sequence)
Recommended Name: Homeobox protein Hox-C8  
Size: 242 amino acids; 27755 Da
Subunit: Interacts with SMAD1 and HOMEZ
Secondary accessions: A8K4J4 O15221 O15362

Explore the universe of human proteins at neXtProt for HOXC8: NX_P31273

Explore proteomics data for HOXC8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXC8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_073149.1  
    ENSEMBL proteins: 
     ENSP00000040584  

    HOXC8 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for HOXC8
    OriGene Protein Over-expression Lysate for HOXC8
    OriGene MassSpec for HOXC8
    OriGene Custom Protein Services for HOXC8
    GenScript Custom Purified and Recombinant Proteins Services for HOXC8
    Novus Biologicals HOXC8 Proteins
    Novus Biologicals HOXC8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXC8

    HOXC8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HOXC8
    OriGene Custom Antibody Services for HOXC8
    Novus Biologicals HOXC8 Antibodies
    Abcam antibodies for HOXC8
    Cloud-Clone Corp. Antibodies for HOXC8
    ThermoFisher Antibodies for HOXC8
    LSBio Antibodies in human, mouse, rat for HOXC8

    HOXC8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HOXC8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXC8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HOXC8
    Cloud-Clone Corp. CLIAs for HOXC8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry P31273

    ProtoNet protein and cluster: P31273

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXC8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXC8_HUMAN, P31273
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXC8:
    homeo box C8(3A),homologous to mouse Hox-3.1,involved in mouse anterior and posterior patterning and innervation
    of the limb

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    HOXC8 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Hoxc8):
     behavior/neurological  growth/size/body  integument  limbs/digits/tail  mortality/aging 
     muscle  nervous system  no phenotypic analysis  skeleton 

    HOXC8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXC8: Hoxc8tm1.1Rud Hoxc8tm1Rud

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXC8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXC8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXC8

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXC8:
    hsa-mir-26a-5p (MIRT050144), hsa-mir-196b-5p (MIRT004638), hsa-mir-19b-3p (MIRT031090), hsa-mir-130b-3p (MIRT020127), hsa-mir-196a-5p (MIRT002942), hsa-mir-148a-3p (MIRT026011)

    Block miRNA regulation of human, mouse, rat HOXC8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC8 (see all 81):
    hsa-miR-26a-2* hsa-miR-300 hsa-miR-376b hsa-miR-15a hsa-miR-1245 hsa-miR-890 hsa-miR-3170 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidHOXC8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXC8
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HOXC8

    Clone
    Products:
         
    OriGene clones in human, mouse for HOXC8 (see all 5)
    OriGene ORF clones in mouse, rat for HOXC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXC8 (NM_022658)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC8

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HOXC8
    Browse ESI BIO Cell Lines and PureStem Progenitors for HOXC8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HXC8_HUMAN, P31273: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0015630microtubule cytoskeleton IDA--

    HOXC8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including HOXC8: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HOXC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for HOXC8 (P312733 ENSP000000405844) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    DLX5P561783, ENSP000002225984I2D: score=1 STRING: ENSP00000222598
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    HOMEZQ8IX153, ENSP000003500494I2D: score=1 STRING: ENSP00000350049
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development ----
    GO:0009952anterior/posterior pattern specification IEA--

    HOXC8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXC8 (HXC8)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HOXC8 gene: 
    NM_022658.3  

    Unigene Cluster for HOXC8:

    Homeobox C8
    Hs.664500  [show with all ESTs]
    Unigene Representative Sequence: NM_022658
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000040584(uc001ser.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXC8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC8 (see all 81):
    hsa-miR-26a-2* hsa-miR-300 hsa-miR-376b hsa-miR-15a hsa-miR-1245 hsa-miR-890 hsa-miR-3170 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidHOXC8 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXC8
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC8
    Clone
    Products:
         
    OriGene clones in human, mouse for HOXC8 (see all 5)
    OriGene ORF clones in mouse, rat for HOXC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXC8 (NM_022658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC8
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HOXC8
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXC8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC8
      QuantiTect SYBR Green Assays in human, mouse, rat HOXC8
      QuantiFast Probe-based Assays in human, mouse, rat HOXC8

    Additional mRNA sequence: 

    AK290959.1 BC053898.1 X99680.1 X99681.1 

    2 DOTS entries:

    DT.92021819  DT.100016368 

    14 AceView cDNA sequences:

    CA440645 NM_022658 X99680 AI864052 BC053898 AI672013 BU618342 BE006215 
    BQ427662 AW207560 CA427346 X99681 BU156590 BG121046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HOXC8 expression in normal human tissues (normalized intensities)      HOXC8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTCCTCTC
    HOXC8 Expression
    About this image


    HOXC8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Spinal Cord (Nervous System)    fully expand to see all 6 entries
             Motor neuron progenitors
     
     Motor Neurons (Nervous System)    fully expand to see all 5 entries
             Motor neuron-like cells
     
     Neurons
             Motor neuron-like cells
     
     Somite (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
     
     Epithelial Cells
             Intermediate Keratinocytes Embryonic Epidermis
    HOXC8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXC8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664500
        Pathway & Disease-focused RT2 Profiler PCR Array including HOXC8: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HOXC8
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXC8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC8
    QuantiTect SYBR Green Assays in human, mouse, rat HOXC8
    QuantiFast Probe-based Assays in human, mouse, rat HOXC8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HOXC8 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxc81 , 5 homeobox C81, 5 95.59(n)1
    99.59(a)1
      15 (58.05 cM)5
    154261  NM_010466.21  NP_034596.11 
     1029906225 
    chicken
    (Gallus gallus)
    Aves HOXC81 homeobox C8 82.72(n)
    93.12(a)
      395711  NM_204893.1  NP_990224.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXC86
    homeobox C8
    93(a)
    1 ↔ 1
    2(72050329-72055688)
    African clawed frog
    (Xenopus laevis)
    Amphibia xhoxc82 homeobox protein pXhoxc8 81.25(n)    AF001596.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxc8a2 homeo box C8a 75.72(n)   30347  CK019325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubx6
    abd-A6
    abdominal A
    20(a)
    14(a)
    many ↔ many
    many ↔ many
    3R(12482345-12560348)
    3R(12632936-12655767)
    worm
    (Caenorhabditis elegans)
    Secernentea mab-56
    lin-396
    Protein LIN-39 (lin-39) mRNA, complete cds
    33(a)
    26(a)
    many ↔ many
    many ↔ many
    III(7776907-7783454) WBGene00003102
    III(7528668-7536632) WBGene00003024


    ENSEMBL Gene Tree for HOXC8 (if available)
    TreeFam Gene Tree for HOXC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HOXC8 gene
    HOXA72  HOXB52  HOXC62  HOXC52  HOXB42  HOXA52  ENSG000002732662  HOXA42  
    HOXA62  ENSG000002730492  HOXD82  HOXB62  HOXB82  HOXD42  HOXB72  HOXC42  
    7 SIMAP similar genes for HOXC8 using alignment to 1 protein entry:     HXC8_HUMAN:
    HOXB8    HOXD8    HOXA6    HOXA7    HOXB7    HOXC5
    HOXB6

    HOXC8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for HOXC8 (see all 112)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500806291,2
    --54401047(+) GATAAC/TAGGGG 1 -- us2k10--------
    rs1150146171,2
    C,F--54401194(+) TCCAAC/TCCTGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs72994421,2
    C,F--54401331(+) CTGTGA/GGGTGG 1 -- us2k16Minor allele frequency- G:0.13NA WA EA 364
    rs1145659351,2
    C,F--54401534(+) GCACAC/TAGCAT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1454496191,2
    --54401568(+) TTTTCC/TCTCTG 1 -- us2k10--------
    rs619217791,2
    C--54401609(+) TTATGG/ACCAGA 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1488597371,2
    --54401615(+) CCAGAA/GAAGGG 1 -- us2k10--------
    rs124233701,2
    C,H--54401631(+) ATGGAC/ATAAGG 1 -- us2k13Minor allele frequency- A:0.17NA 6
    rs1469553091,2
    --54401665(+) TTGAAC/TGTATT 1 -- us2k10--------
    rs1148543471,2
    C,F--54401679(+) TCTTGG/AGGATG 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for HOXC8 (54402832 - 54407570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOXC8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672088CNV Deletion23128226
    nsv899102CNV Loss21882294
    nsv899101CNV Loss21882294
    nsv899100CNV Loss21882294
    nsv826379CNV Gain20364138
    nsv428282CNV Gain18775914
    dgv512e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXC8
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXC8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 142970    OMIM disorders: --

    10 diseases for HOXC8:    About MalaCards
    pancreatic ductal adenocarcinoma    chondrodysplasia    pancreatitis    adenocarcinoma
    prostate cancer    prostatitis    cerebritis    breast cancer
    leukemia    neuronitis


    HOXC8 for disorders           About GeneDecksing


    Export disorders for HOXC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HOXC8 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with HOXC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PubMed id 12925734)1, 2 Bayarsaihan D.... Ruddle F.H. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    3. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (Teratology 2002)
    4. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PubMed id 9357979)1, 2 Flagiello D.... Malfoy B. (FEBS Lett. 1997)
    5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    6. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    7. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
    8. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. (PubMed id 11139569)1, 9 Wan M....Cao X. (J. Biol. Chem. 2001)
    9. Expression of HOXC8 is inversely related to the progression and metastasis of pancreatic ductal adenocarcinoma. (PubMed id 21712827)1 Adwan H....Berger M.R. (Br. J. Cancer 2011)
    10. HOXC8 inhibits androgen receptor signaling in human prostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes. (PubMed id 21047772)1 Axlund S.D....Nordeen S.K. (Mol. Cancer Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3224 HGNC: 5129 AceView: HOXC8 Ensembl:ENSG00000037965 euGenes: HUgn3224
    ECgene: HOXC8 H-InvDB: HOXC8

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HOXC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HOXC8 gene:
    Search GeneIP for patents involving HOXC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HOXC8   OriGene RNAi products in human, mouse, rat for HOXC8  
     OriGene qPCR primer pairs and template standards for HOXC8   OriGene Protein Over-expression Lysate for HOXC8  
     OriGene MassSpec something-or-other for HOXC8   OriGene clones in human, mouse for HOXC8  
     OriGene qSTAR qPCR primer pairs in human, mouse for HOXC8   OriGene Purified Protein for HOXC8  
     OriGene ORF clones in mouse, rat for HOXC8   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXC8   OriGene Custom Protein Services for HOXC8  

     
     
     Block miRNA regulation of human, mouse, rat HOXC8 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HOXC8
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXC8 Predesigned siRNA for gene silencing in human, mouse, rat HOXC8
     QuantiFast Probe-based Assays in human, mouse, rat HOXC8 QuantiTect SYBR Green Assays in human, mouse, rat HOXC8
     PCR Arrays including human, mouse, rat HOXC8 Search Chromatin IP Primers for HOXC8
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC8  GeneGlobe Interaction Network for HOXC8
     Regulatory tfbs in HOXC8 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HOXC8 GenScript cDNA clones with any tag delivered in your preferred vector for HOXC8
     GenScript Custom Assay Services for HOXC8 GenScript Custom overexpressing Cell Line Services for HOXC8
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HOXC8 (HXC8)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HOXC8 antibodies
     HOXC8 proteins
     HOXC8 lysates
     Antibodies for HOXC8
     See all of Abcam's Antibodies, Kits and Proteins for HOXC8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HOXC8
     Antibodies for HOXC8
     ELISAs for HOXC8
     CLIAs for HOXC8



     Browse ESI BIO Cell Lines and PureStem Progenitors for HOXC8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC8
     SwitchGear 3'UTR luciferase reporter plasmids for HOXC8
     SwitchGear Promoter luciferase reporter plasmids for HOXC8
     ThermoFisher Antibodies for HOXC8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC8
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXC8
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXC8
     LSBio Antibodies in human, mouse, rat for HOXC8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HOXC8 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4