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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXC8 Gene

protein-coding   GIFtS: 51
GCID: GC12P054402

Homeobox C8

(Previous name: homeo box C8)
(Previous symbols: HOX3, HOX3A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homeobox C81 2     Homeobox Protein Hox-3A2 3
HOX3A1 2 3 5     Homeo Box 3A2
HOX31 2     Homeobox Protein Hox-C82
Homeo Box C81 2     Hox-3.1, Mouse, Homolog Of2

External Ids:    HGNC: 51291   Entrez Gene: 32242   Ensembl: ENSG000000379657   OMIM: 1429705   UniProtKB: P312733   

Export aliases for HOXC8 gene to outside databases

Previous GC identifers: GC12M054416 GC12P054515 GC12P054119 GC12P052689 GC12P051440


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXC8 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes
located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage
differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. (provided by
RefSeq, Jul 2008)

GeneCards Summary for HOXC8 Gene: 
HOXC8 (homeobox C8) is a protein-coding gene. Diseases associated with HOXC8 include pancreatic ductal adenocarcinoma, and chondrodysplasia. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXC8 gene promoter:
         Sp1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXC8 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXC8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054402:  view genomic region     (about GC identifiers)

Start:
54,402,832 bp from pter      End:
54,407,570 bp from pter
Size:
4,739 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273 (See protein sequence)
Recommended Name: Homeobox protein Hox-C8  
Size: 242 amino acids; 27755 Da
Subunit: Interacts with SMAD1 and HOMEZ
Subcellular location: Nucleus
Secondary accessions: A8K4J4 O15221 O15362

Explore the universe of human proteins at neXtProt for HOXC8: NX_P31273

Explore proteomics data for HOXC8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31273

  • HOXC8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXC8 Protein Expression
    REFSEQ proteins: NP_073149.1  
    ENSEMBL proteins: 
     ENSP00000040584  

    Human Recombinant Protein Products for HOXC8: 
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    Novus Biologicals HOXC8 Proteins
    Novus Biologicals HOXC8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXC8 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    HOXC8 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for HOXC8 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P31273

    ProtoNet protein and cluster: P31273

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXC8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXC8_HUMAN, P31273
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXC8:
    homeo box C8(3A),homologous to mouse Hox-3.1,involved in mouse anterior and posterior patterning and innervation
    of the limb

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0043565sequence-specific DNA binding ----
         
    HOXC8 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Hoxc8):
     behavior/neurological  growth/size  integument  limbs/digits/tail  mortality/aging 
     muscle  nervous system  no phenotypic analysis  skeleton 

    HOXC8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXC8: Hoxc8tm1.1Rud Hoxc8tm1Rud

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXC8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXC8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXC8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXC8 

    miRNA
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    miRTarBase miRNAs that target HOXC8:
    hsa-mir-196b (MIRT004638), hsa-mir-196a (MIRT002942)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXC8
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC8 (see all 81):
    hsa-miR-26a-2* hsa-miR-300 hsa-miR-376b hsa-miR-15a hsa-miR-1245 hsa-miR-890 hsa-miR-3170 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidHOXC8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXC8
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of HOXC8

    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/17 Interacting proteins for HOXC8 (P312733 ENSP000000405844) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    DLX5P561783, ENSP000002225984I2D: score=1 STRING: ENSP00000222598
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    HOMEZQ8IX153, ENSP000003500494I2D: score=1 STRING: ENSP00000350049
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS--
    GO:0009952anterior/posterior pattern specification IEA--

    HOXC8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXC8 (HXC8)

    Search CenterWatch for drugs/clinical trials and news about HOXC8 / HXC8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXC8 gene: 
    NM_022658.3  

    Unigene Cluster for HOXC8:

    Homeobox C8
    Hs.664500  [show with all ESTs]
    Unigene Representative Sequence: NM_022658
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000040584(uc001ser.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXC8
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC8 (see all 81):
    hsa-miR-26a-2* hsa-miR-300 hsa-miR-376b hsa-miR-15a hsa-miR-1245 hsa-miR-890 hsa-miR-3170 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidHOXC8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXC8
    Clone
    Products:
         
    OriGene clones in human, mouse for HOXC8 (see all 6)
    OriGene ORF clones in mouse, rat for HOXC8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXC8 (NM_022658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC8
    Sirion Biotech Customized lentivirus for stable overexpression of HOXC8 
                         Customized lentivirus expression plasmids for stable overexpression of HOXC8 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HOXC8
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXC8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXC8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXC8

    Additional mRNA sequence: 

    AK290959.1 BC053898.1 X99680.1 X99681.1 

    2 DOTS entries:

    DT.92021819  DT.100016368 

    14 AceView cDNA sequences:

    BC053898 NM_022658 CA440645 X99680 AI864052 AI672013 BQ427662 BE006215 
    BU618342 CA427346 AW207560 X99681 BU156590 BG121046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXC8 expression in normal human tissues (normalized intensities)      HOXC8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTCCTCTC
    HOXC8 Expression
    About this image


    HOXC8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Dermis (Integumentary System)    fully expand to see all 7 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Fibroblast
             Human Lymphatic Fibroblasts (HLF)   
     
     Somite (Muscoskeletal System)    fully expand to see all 4 entries
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
             mesenchyme/trunk mesenchyme/paraxial mesenchyme   
     
     Hair
             Outer Root Sheath Cells Outer Root Sheath
             Human Hair Outer Root Sheath Cells (HHORSC)   
     
     Adipose (Muscoskeletal System)    fully expand to see all 4 entries
             Body Subcutaneous White Adipose
             Human Preadipocyte-subcutaneous (HPA-s)   

    See HOXC8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXC8

    SOURCE GeneReport for Unigene cluster: Hs.664500
        SABiosciences Expression via Pathway-Focused PCR Array including HOXC8: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXC8 gene from 5/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxc81 , 5 homeobox C81, 5 95.59(n)1
    99.59(a)1
      15 (58.05 cM)5
    154261  NM_010466.21  NP_034596.11 
     1029906225 
    lizard
    (Anolis carolinensis)
    Reptilia HOXC86
    Uncharacterized protein
    93(a)
    1 ↔ 1
    2(72050329-72055688)
    African clawed frog
    (Xenopus laevis)
    Amphibia xhoxc82 homeobox protein pXhoxc8 81.25(n)    AF001596.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxc8a2 homeo box C8a 75.72(n)   30347  CK019325.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubx6
    abd-A6
    abdominal A
    22(a)
    11(a)
    many ↔ many
    many ↔ many
    3R(12482345-12560348)
    3R(12632936-12655767)


    ENSEMBL Gene Tree for HOXC8 (if available)
    TreeFam Gene Tree for HOXC8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXC8 gene
    GSX12  HOXA72  HOXA12  HOXB32  HOXD12  HOXA22  HOXB52  HOXC62  
    HOXC52  GSX22  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXA32  
    HOXD82  HOXB62  HOXB12  HOXB82  HOXD42  HOXB22  PDX12  HOXB72  
    HOXC42  
    7 SIMAP similar genes for HOXC8 using alignment to 1 protein entry:     HXC8_HUMAN:
    HOXB8    HOXD8    HOXA6    HOXA7    HOXB7    HOXC5
    HOXB6

    HOXC8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/112 SNPs in HOXC8 are shown (see all 112)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1500806291,2
    --54401047(+) GATAAC/TAGGGG 1 -- us2k10--------
    rs1150146171,2
    C,F--54401194(+) TCCAAC/TCCTGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs72994421,2
    C,F--54401331(+) CTGTGA/GGGTGG 1 -- us2k16Minor allele frequency- G:0.13NA WA EA 364
    rs1145659351,2
    C,F--54401534(+) GCACAC/TAGCAT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1454496191,2
    --54401568(+) TTTTCC/TCTCTG 1 -- us2k10--------
    rs619217791,2
    C--54401609(+) TTATGG/ACCAGA 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1488597371,2
    --54401615(+) CCAGAA/GAAGGG 1 -- us2k10--------
    rs124233701,2
    C,H--54401631(+) ATGGAC/ATAAGG 1 -- us2k13Minor allele frequency- A:0.17NA 6
    rs1469553091,2
    --54401665(+) TTGAAC/TGTATT 1 -- us2k10--------
    rs1148543471,2
    C,F--54401679(+) TCTTGG/AGGATG 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for HOXC8 (54402832 - 54407570 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOXC8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2672088CNV Deletion23128226
    nsv899102CNV Loss21882294
    nsv899101CNV Loss21882294
    nsv899100CNV Loss21882294
    nsv826379CNV Gain20364138
    nsv428282CNV Gain18775914
    dgv512e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142970    OMIM disorders: --

    8 diseases for HOXC8:    About MalaCards
    pancreatic ductal adenocarcinoma    chondrodysplasia    adenocarcinoma    pancreatitis
    prostate cancer    prostatitis    breast cancer    leukemia


    HOXC8 for disorders           About GeneDecksing


    Export disorders for HOXC8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXC8 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with HOXC8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PubMed id 12925734)1, 2 Bayarsaihan D.... Ruddle F.H. (2003)
    3. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    4. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PubMed id 9357979)1, 2 Flagiello D.... Malfoy B. (1997)
    5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    6. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    7. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    8. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. (PubMed id 11139569)1, 9 Wan M....Cao X. (2001)
    9. Expression of HOXC8 is inversely related to the progr ession and metastasis of pancreatic ductal adenocarcinoma. (PubMed id 21712827)1 Adwan H....Berger M.R. (2011)
    10. HOXC8 inhibits androgen receptor signaling in human p rostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes. (PubMed id 21047772)1 Axlund S.D....Nordeen S.K. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3224 HGNC: 5129 AceView: HOXC8 Ensembl:ENSG00000037965 euGenes: HUgn3224
    ECgene: HOXC8 H-InvDB: HOXC8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXC8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXC8 gene:
    Search GeneIP for patents involving HOXC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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