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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXC8 Gene

protein-coding   GIFtS: 51
GCID: GC12P054402

homeobox C8

(Previous name: homeo box C8 )
(Previous symbols: HOX3, HOX3A)
 Explore 12 diseases affiliated with
HOXC8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXC8    

Aliases
for HOXC8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox C81 2     Homeobox Protein Hox-3A2 3
HOX3A1 2 3 5     Homeo Box 3A2
HOX31 2     Homeobox Protein Hox-C82
Homeo Box C81 2     Hox-3.1, Mouse, Homolog Of2

External Ids:    HGNC: 51291   Entrez Gene: 32242   Ensembl: ENSG000000379657   OMIM: 1429705   UniProtKB: P312733   

Export aliases for HOXC8 gene to outside databases

Previous GC identifers: GC12M054416 GC12P054515 GC12P054119 GC12P052689 GC12P051440


Summaries
for HOXC8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXC8:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription
factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar
homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11
genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The
product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in
chondrodysplasias or other cartilage disorders. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC8


Genomic Views
for HOXC8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXC8 gene promoter:
         Sp1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXC8 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXC8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXC8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC8 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054402:  view genomic region     (about GC identifiers)

Start:
 54,402,832 bp from pter      End:
 54,407,570 bp from pter
Size:
 4,739 bases      Orientation:
 plus strand

Proteins
for HOXC8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273 (See protein sequence)
Recommended Name: Homeobox protein Hox-C8  
Size: 242 amino acids; 27755 Da
Subunit: Interacts with SMAD1 and HOMEZ
Subcellular location: Nucleus
Secondary accessions: A8K4J4 O15221 O15362

Explore the universe of human proteins at neXtProt for HOXC8: NX_P31273

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31273

    • HOXC8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_073149.1  
    ENSEMBL proteins: 
     ENSP00000040584  

    Human Recombinant Protein Products: 
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    Novus Biologicals HOXC8 Proteins
    Novus Biologicals HOXC8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXC8

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    HOXC8 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HOXC8

    Protein Domains /
    Families
    for HOXC8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXC8 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P31273

    ProtoNet protein and cluster: P31273

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXC8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXC8_HUMAN, P31273
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXC8:
    homeo box C8(3A),homologous to mouse Hox-3.1,involved in mouse anterior and posterior patterning and innervation of the
    limb

    miRNA
    Products:            		miRTarBase miRNAs that target HOXC8:
    hsa-mir-196b (MIRT004638), hsa-mir-196a (MIRT002942)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXC8
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC8 (see all 81):
    hsa-miR-26a-2* hsa-miR-300 hsa-miR-376b hsa-miR-15a hsa-miR-1245 hsa-miR-890 hsa-miR-3170 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: HOXC8 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXC8 (see all 4)
    OriGene shRNA RFP: HOXC8
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXC8

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXC8 (NM_022658)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC8 

    Cell Line
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    Search LifeMap BioReagents cell lines for HOXC8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC8

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--


    HOXC8 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for HOXC8: Hoxc8tm1.1Rud Hoxc8tm1Rud
         9 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Hoxc8):
     behavior/neurological  growth/size  integument  limbs/digits/tail  mortality/aging 
     muscle  nervous system  no phenotypic analysis  skeleton 

    HOXC8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXC8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXC8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for HOXC8 (P312733 ENSP000000405844) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    BMPR1AP368943, ENSP000002247644I2D: score=1 STRING: ENSP00000224764
    DLX5P561783, ENSP000002225984I2D: score=1 STRING: ENSP00000222598
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS--
    GO:0009952anterior/posterior pattern specification IEA--


    HOXC8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXC8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXC8
    Search CenterWatch for drugs/clinical trials and news about HOXC8 / HXC8 

    Transcripts
    for HOXC8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXC8 gene: 
    NM_022658.3  

    Unigene Cluster for HOXC8:

    Homeobox C8
    Hs.664500  [show with all ESTs]
    Unigene Representative Sequence: NM_022658
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000040584(uc001ser.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXC8
    8/81 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC8 (see all 81):
    hsa-miR-26a-2* hsa-miR-300 hsa-miR-376b hsa-miR-15a hsa-miR-1245 hsa-miR-890 hsa-miR-3170 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmid: HOXC8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXC8 (see all 4)
    OriGene shRNA RFP: HOXC8
    OriGene siRNA: HOXC8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXC8
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXC8 (NM_022658)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXC8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXC8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXC8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXC8

    Additional cDNA sequence: 

    AK290959.1 BC053898.1 X99680.1 X99681.1 

    2 DOTS entries:

    DT.92021819  DT.100016368 

    14 AceView cDNA sequences:

    CA440645 X99680 AI864052 AI672013 BC053898 NM_022658 CA427346 BE006215 
    BU618342 AW207560 BQ427662 X99681 BU156590 BG121046 

    GeneLoc Exon Structure


    Expression
    for HOXC8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXC8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTCCTCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXC8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    8 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteThoracic Mesenchymal SclerotomeThoracic Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    SomiteThoracic Ventrolateral Dermomyotome LipMuscle Progenitor CellsSkeletal Muscle
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    AdiposeBody Subcutaneous White AdiposeAdipose
    AdiposeVisceral White AdiposeAdipose
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Motor neuron-like cells (Generation of motor ...)Motor Neurons, Spinal Cord
    Motor neuron progenitors (Differentiation of ...)

    See HOXC8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXC8

    SOURCE GeneReport for Unigene cluster: Hs.664500
        SABiosciences Expression via Pathway-Focused PCR Array including HOXC8: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC8

    Orthologs
    for HOXC8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXC8 gene from 5/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia HOXC86
    		 --
    		 93(a)
    		 1 ↔ 1
    		 2(72052127-72054927)
    African clawed frog
    (Xenopus laevis)    		 Amphibia xhoxc82 homeobox protein pXhoxc8 81.25(n)    AF001596.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxc8a2 homeo box C8a 75.72(n)   30347  CK019325.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta zen26
    Ubx6
    (see all 4)    		 Ultrabithorax
    (see all 4)    		 17(a)
    15(a)
    (see all 4)    		 possible ortholog
    many ↔ many
    (see all 4)    		 3R(2568854-2569862)
    3R(12482345-12560348)
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-396
    egl-56
    		 Homeobox protein egl-5
    		 19(a)
    18(a)
    		 possible ortholog
    1 ↔ many
    		 III(7528603-7536567)
    III(7814317-7816386)


    ENSEMBL Gene Tree for HOXC8 (if available)
    TreeFam Gene Tree for HOXC8 (if available) 

    Paralogs
    for HOXC8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXC8 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXA32  
    HOXD82  HOXB12  HOXB62  HOXB82  HOXD42  HOXB22  HOXB72  PDX12  
    HOXC42  
    7 SIMAP similar genes for HOXC8 using alignment to 1 protein entry:     HXC8_HUMAN:
    HOXB8    HOXD8    HOXA6    HOXA7    HOXB7    HOXC5
    HOXB6

    HOXC8 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXC8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/88 NCBI SNPs in HOXC8 are shown (see all 88)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1500806291,2
    		--54401047(+) GATAAC/TAGGGG 1 -- us2k10--------
    rs1150146171,2
    		F,--54401194(+) TCCAAC/TCCTGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs72994421,2
    		C,F,--54401331(+) CTGTGA/GGGTGG 1 -- us2k16Minor allele frequency- G:0.13NA WA EA 364
    rs1145659351,2
    		F,--54401534(+) GCACAC/TAGCAT 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1454496191,2
    		--54401568(+) TTTTCC/TCTCTG 1 -- us2k10--------
    rs619217791,2
    		C,--54401609(+) NNNNGG/ACCAGA 1 -- us2k12Minor allele frequency- A:0.04NA 122
    rs1488597371,2
    		--54401615(+) CCAGAA/GAAGGG 1 -- us2k10--------
    rs124233701,2
    		C,H--54401631(+) ATGGAC/ATAAGG 1 -- us2k13Minor allele frequency- A:0.17NA 6
    rs1469553091,2
    		--54401665(+) TTGAAC/TGTATT 1 -- us2k10--------
    rs1148543471,2
    		F,--54401679(+) TCTTGG/AGGATG 1 -- us2k11Minor allele frequency- A:0.04WA 118

    HapMap Linkage Disequilibrium report for HOXC8 (54402832 - 54407570 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HOXC8
         1 CNV: 3890

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXC8
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    Disorders / Diseases
    for HOXC8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXC8 for disorders           About GeneDecksing

    OMIM gene information: 142970    OMIM disorders: --

    12 diseases for HOXC8:    About MalaCards
    chondrodysplasia    adrenal hyperplasia    pancreatic ductal adenocarcinoma    lung carcinoma
    adenocarcinoma    prostate cancer    breast cancer    pancreatitis
    prostatitis    carcinoma    leukemia    neuronitis


    Export disorders for HOXC8 gene to outside databases

    Publications
    for HOXC8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXC8 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with HOXC8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PubMed id 12925734)1, 2 Bayarsaihan D.... Ruddle F.H. (2003)
    3. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    4. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PubMed id 9357979)1, 2 Flagiello D.... Malfoy B. (1997)
    5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    6. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    7. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    8. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. (PubMed id 11139569)1, 9 Wan M....Cao X. (2001)
    9. Expression of HOXC8 is inversely related to the progr ession and metastasis of pancreatic ductal adenocarcinoma. (PubMed id 21712827)1 Adwan H....Berger M.R. (2011)
    10. HOXC8 inhibits androgen receptor signaling in human p rostate cancer cells by inhibiting SRC-3 recruitment to direct androgen target genes. (PubMed id 21047772)1 Axlund S.D....Nordeen S.K. (2010)

    External Searches for HOXC8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing HOXC8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3224 HGNC: 5129 AceView: HOXC8 Ensembl:ENSG00000037965 euGenes: HUgn3224
    ECgene: HOXC8 H-InvDB: HOXC8

    Other Databases showing HOXC8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXC8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXC8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXC8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXC8 gene:
    Search GeneIP for patents involving HOXC8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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