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Aliases for HOXC8 Gene

Aliases for HOXC8 Gene

  • Homeobox C8 2 3 5
  • Homeobox Protein Hox-3A 3 4
  • Homeo Box C8 2 3
  • HOX3A 3 4
  • Hox-3.1, Mouse, Homolog Of 3
  • Homeobox Protein Hox-C8 3
  • Homeo Box 3A 3
  • HOX3 3

External Ids for HOXC8 Gene

Previous HGNC Symbols for HOXC8 Gene

  • HOX3
  • HOX3A

Previous GeneCards Identifiers for HOXC8 Gene

  • GC12M054416
  • GC12P054515
  • GC12P054119
  • GC12P052689
  • GC12P054402
  • GC12P051440

Summaries for HOXC8 Gene

Entrez Gene Summary for HOXC8 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the regulation of cartilage differentiation. It could also be involved in chondrodysplasias or other cartilage disorders. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC8 Gene

HOXC8 (Homeobox C8) is a Protein Coding gene. Among its related pathways are Differentiation of white and brown adipocyte. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXD8.

UniProtKB/Swiss-Prot for HOXC8 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXC8 Gene

Additional gene information for HOXC8 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC8 Gene

Genomics for HOXC8 Gene

Regulatory Elements for HOXC8 Gene

Enhancers for HOXC8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H054009 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 15.2 +13.0 12997 25.8 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 CBX5 ZNF143 ZNF207 DEK RARG AAAS ATF7 ENSG00000260470 LOC105378250 HOXC8 SMUG1 IGFBP6 HOXC-AS1 CBX5
GH12H053971 2 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -18.9 -18864 36.8 PKNOX1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 ZNF766 ZNF416 ZNF207 HNRNPA1 ZNF740 ENSG00000258344 ATF7 PCBP2 MAP3K12 LOC100652999 SP1 CALCOCO1 AAAS
GH12H053378 1.4 ENCODE dbSUPER 19.3 -628.2 -628179 5.6 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SP1 PRR13 AAAS HOXC8 HOXC9 ENSG00000258086 AMHR2 SP7 HOXC5 EIF4B
GH12H054323 1.4 Ensembl ENCODE 19.3 +318.8 318782 8.3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ATF7 HOXC8 HOXC9 ENSG00000258086 HOXC5 GPR84 SP1 HOXC6 HOXC4 PCBP2
GH12H054354 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +348.9 348896 6.6 FEZF1 YBX1 YY1 ZNF143 SP3 MCM3 NFYC MEF2D ZNF610 GLIS1 SP1 PCBP2 ENSG00000258344 CBX5 GPR84 ZNF385A MAP3K12 ATF7 LOC100652999 HNRNPA1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOXC8 on UCSC Golden Path with GeneCards custom track

Promoters for HOXC8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000052277 194 201 INSM2 KLF17 BMI1 KLF7 EGR2 REST ZEB2 KLF16 ZNF524 ZBTB33

Transcription factor binding sites by QIAGEN in the HOXC8 gene promoter:

Genomic Locations for HOXC8 Gene

Genomic Locations for HOXC8 Gene
chr12:54,009,106-54,012,763
(GRCh38/hg38)
Size:
3,658 bases
Orientation:
Plus strand
chr12:54,402,832-54,407,570
(GRCh37/hg19)

Genomic View for HOXC8 Gene

Genes around HOXC8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXC8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXC8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC8 Gene

Proteins for HOXC8 Gene

  • Protein details for HOXC8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31273-HXC8_HUMAN
    Recommended name:
    Homeobox protein Hox-C8
    Protein Accession:
    P31273
    Secondary Accessions:
    • A8K4J4
    • O15221
    • O15362

    Protein attributes for HOXC8 Gene

    Size:
    242 amino acids
    Molecular mass:
    27755 Da
    Quaternary structure:
    • Interacts with SMAD1 and HOMEZ.

neXtProt entry for HOXC8 Gene

Post-translational modifications for HOXC8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC8 Gene

Domains & Families for HOXC8 Gene

Gene Families for HOXC8 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for HOXC8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31273

UniProtKB/Swiss-Prot:

HXC8_HUMAN :
  • Belongs to the Antp homeobox family.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXC8: view

Function for HOXC8 Gene

Molecular function for HOXC8 Gene

GENATLAS Biochemistry:
homeo box C8(3A),homologous to mouse Hox-3.1,involved in mouse anterior and posterior patterning and innervation of the limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Phenotypes From GWAS Catalog for HOXC8 Gene

Gene Ontology (GO) - Molecular Function for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC8: view
genes like me logo Genes that share phenotypes with HOXC8: view

Animal Models for HOXC8 Gene

MGI Knock Outs for HOXC8:

Animal Model Products

CRISPR Products

miRNA for HOXC8 Gene

miRTarBase miRNAs that target HOXC8

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXC8

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC8 Gene

Localization for HOXC8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC8 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXC8 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with HOXC8: view

Pathways & Interactions for HOXC8 Gene

genes like me logo Genes that share pathways with HOXC8: view

Pathways by source for HOXC8 Gene

1 BioSystems pathway for HOXC8 Gene

SIGNOR curated interactions for HOXC8 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HOXC8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXC8: view

Drugs & Compounds for HOXC8 Gene

No Compound Related Data Available

Transcripts for HOXC8 Gene

mRNA/cDNA for HOXC8 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC8 Gene

Homeobox C8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXC8

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC8 Gene

No ASD Table

Relevant External Links for HOXC8 Gene

GeneLoc Exon Structure for
HOXC8
ECgene alternative splicing isoforms for
HOXC8

Expression for HOXC8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXC8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC8 Gene

This gene is overexpressed in Muscle - Skeletal (x7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXC8 Gene



NURSA nuclear receptor signaling pathways regulating expression of HOXC8 Gene:

HOXC8

SOURCE GeneReport for Unigene cluster for HOXC8 Gene:

Hs.664500

Evidence on tissue expression from TISSUES for HOXC8 Gene

  • Eye(4)
genes like me logo Genes that share expression patterns with HOXC8: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC8 Gene

Orthologs for HOXC8 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXC8 33 34
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia HOXC8 33 34
  • 97.38 (n)
rat
(Rattus norvegicus)
Mammalia Hoxc8 33
  • 95.87 (n)
mouse
(Mus musculus)
Mammalia Hoxc8 33 16 34
  • 95.59 (n)
dog
(Canis familiaris)
Mammalia LOC607625 33
  • 95.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC8 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXC8 33
  • 82.72 (n)
lizard
(Anolis carolinensis)
Reptilia HOXC8 34
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc8 33
  • 83.49 (n)
African clawed frog
(Xenopus laevis)
Amphibia xhoxc8 33
zebrafish
(Danio rerio)
Actinopterygii hoxc8a 33 33 34
  • 75.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ubx 34
  • 20 (a)
ManyToMany
abd-A 34
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea mab-5 34
  • 33 (a)
ManyToMany
lin-39 34
  • 26 (a)
ManyToMany
Species where no ortholog for HOXC8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HOXC8 Gene

ENSEMBL:
Gene Tree for HOXC8 (if available)
TreeFam:
Gene Tree for HOXC8 (if available)

Paralogs for HOXC8 Gene

(7) SIMAP similar genes for HOXC8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXC8: view

Variants for HOXC8 Gene

Sequence variations from dbSNP and Humsavar for HOXC8 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000190438 -- 54,009,210(+) GGGGA(C/G)GGGAG upstream-variant-2KB, utr-variant-5-prime
rs1001415308 -- 54,012,543(+) TAGAA(C/T)TAAAT utr-variant-3-prime
rs1001904470 -- 54,010,305(+) TTTAT(A/C)CTTCC intron-variant, upstream-variant-2KB
rs1002318335 -- 54,010,732(+) GGAAA(C/T)AGTCT intron-variant, upstream-variant-2KB
rs1002568484 -- 54,013,187(+) AGGGT(A/C)TGGGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HOXC8 Gene

Variant ID Type Subtype PubMed ID
esv2672088 CNV deletion 23128226
esv2759900 CNV gain+loss 17122850
nsv1070530 CNV deletion 25765185
nsv428282 CNV gain 18775914
nsv826379 CNV gain 20364138

Variation tolerance for HOXC8 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXC8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXC8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC8 Gene

Disorders for HOXC8 Gene

Relevant External Links for HOXC8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXC8

No disorders were found for HOXC8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC8 Gene

Publications for HOXC8 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D … Ruddle FH (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 60
  3. Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K … Matsuo N (Teratology 2002) 3 4 60
  4. Transcriptional mechanisms of bone morphogenetic protein-induced osteoprotegrin gene expression. (PMID: 11139569) Wan M … Cao X (The Journal of biological chemistry 2001) 3 22 60
  5. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PMID: 9357979) Flagiello D … Malfoy B (FEBS letters 1997) 3 4 60

Products for HOXC8 Gene

  • Addgene plasmids for HOXC8

Sources for HOXC8 Gene

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