Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXC6 Gene

protein-coding   GIFtS: 50
GCID: GC12P054384

homeobox C6

(Previous name: homeo box C6 )
(Previous symbols: HOX3C, HOX3)
 Explore 16 diseases affiliated with
HOXC6 via our new
 Human Malady Compendium 
Biological research products
for HOXC6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Homeobox C61 2     Homeobox Protein Hox-3C2 3
HOX3C1 2 3 5     CP252
HOX31 2     HHO.C82
Homeo Box C61 2     Homeo Box 3C2
Homeobox Protein CP252 3     Homeo Box C8 Protein2
Homeobox Protein HHO.C82 3     Homeobox Protein Hox-C62

External Ids:    HGNC: 51281   Entrez Gene: 32232   Ensembl: ENSG000001977577   OMIM: 1429725   UniProtKB: P096303   

Export aliases for HOXC6 gene to outside databases

Previous GC identifers: GC12M054395 GC12P054524 GC12P054128 GC12P052697 GC12P052698 GC12P054412 GC12P051450


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXC6:
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors
that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox
gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes
arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes,
HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the
gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants
encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and
transcript variant one includes only gene-specific exons. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXC6_HUMAN, P09630
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXC6 gene promoter:
         Pax-5   Sp1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for HOXC6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054384:  view genomic region     (about GC identifiers)

Start:
54,384,408 bp from pter      End:
54,424,607 bp from pter
Size:
40,200 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HXC6_HUMAN, P09630 (See protein sequence)
Recommended Name: Homeobox protein Hox-C6  
Size: 235 amino acids; 26915 Da
Subcellular location: Nucleus
Secondary accessions: B2RBV2 Q6DK09
Alternative splicing: 2 isoforms:  P09630-1   P09630-2   

Explore the universe of human proteins at neXtProt for HOXC6: NX_P09630

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P09630

  • HOXC6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004494.1  NP_710160.1  

    ENSEMBL proteins: 
     ENSP00000424124   ENSP00000423898   ENSP00000377864   ENSP00000243108  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HOXC6
    OriGene Protein Over-expression Lysate (see all 2): HOXC6
    OriGene Custom Protein Services for HOXC6 
    GenScript Custom Purified and Recombinant Proteins Services for HOXC6
    Novus Biologicals HOXC6 Proteins
    Novus Biologicals HOXC6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXC6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    HOXC6 for ontologies           About GeneDecksing



    HOXC6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HOXC6 
    GenScript Custom Superior Antibodies Services for HOXC6
    Novus Biologicals HOXC6 Antibodies
    Abcam antibodies for HOXC6 
    Uscn Antibodies for HOXC6
    ThermoFisher Antibodies for HOXC6

    Assay Products for HOXC6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXC6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HOXC6


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HOXC6 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P09630

    ProtoNet protein and cluster: P09630

    1 Blocks protein family: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXC6_HUMAN, P09630
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HXC6_HUMAN, P09630
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXC6:
    homeo box C6(3C),homologous to mouse Hox-3.3,Drosophila Antp,Ubx,abd-A,expressed in first trimester
    trophoblast,involved in mouse anterior and posteior limb patterning,expressed in anterior and posterior limbs

    miRNA
    Products:
        
    OriGene 3'-UTR Clone (see all 2): HOXC6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXC6
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC6 (see all 18):
    hsa-miR-892b hsa-miR-642a hsa-miR-1321 hsa-miR-4328 hsa-miR-128 hsa-miR-3074-3p hsa-miR-486-3p hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidHOXC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXC6 (see all 4)
    OriGene shRNA RFP: HOXC6
    OriGene siRNA: HOXC6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXC6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HOXC6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HOXC6 (NM_004503)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HOXC6
    Search LifeMap BioReagents cell lines for HOXC6

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC6

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS8870653
    GO:0043565sequence-specific DNA binding IEA--


    HOXC6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HOXC6:
     Increased number of cells in m 

    Animal Models:
         Mouse knock-out Hoxc6tm1Dds for HOXC6
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hoxc6):
     endocrine/exocrine gland  integument  skeleton 

    HOXC6 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXC6

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for HOXC6 (P096303 ENSP000002431084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    JUNDP175353I2D: score=1 
    PBX3P404263I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8870653
    GO:0007275multicellular organismal development TAS8870653
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0048706embryonic skeletal system development IEA--


    HOXC6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXC6
    Search CenterWatch for drugs/clinical trials and news about HOXC6 / HXC6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXC6 gene (2 alternative transcripts): 
    NM_004503.3  NM_153693.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504315 ENST00000509328 ENST00000394331(uc001ses.3) ENST00000243108(uc001sev.3)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone (see all 2): HOXC6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXC6
    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC6 (see all 18):
    hsa-miR-892b hsa-miR-642a hsa-miR-1321 hsa-miR-4328 hsa-miR-128 hsa-miR-3074-3p hsa-miR-486-3p hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidHOXC6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXC6 (see all 4)
    OriGene shRNA RFP: HOXC6
    OriGene siRNA: HOXC6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXC6
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC6 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC6 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HOXC6 (NM_004503)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC6 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXC6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXC6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXC6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXC6

    24/228 AceView cDNA sequences (see all 228):

    AI275813 AI380130 AI200419 AI174335 BM825403 BU501253 AW000987 NM_014620 
    AA813478 BF058345 AA331371 NM_153693 BQ962391 NM_004503 BC074845 BF197458 
    AW070489 CR615968 CA432146 BM127322 BF434950 BQ890449 BF591158 BF057562 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTACCTGCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    HOXC6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteThoracic Mesenchymal SclerotomeThoracic Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    Spinal CordCaudal Brachial Lateral Motor ColumnLateral Motor NeuronsMotor Neurons
    Spinal CordRostral Brachial Lateral Motor ColumnLateral Motor NeuronsMotor Neurons
    Spinal CordRostral Brachial Lateral Motor DivisionLateral Neurons Of The LMCMotor Neurons
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    Motor neuron progenitors (Differentiation of ...)
    Primordial-like germ cells (cKIT+ SSEA1+ VASA+) (Derivation of primor...)
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
    Mesendoderm (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

    See HOXC6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXC6
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXC6: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXC6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXC6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXC6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXC6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXC6 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HOXC61 homeobox C6 79.77(n)
    91.03(a)
      100858368  XM_003643454.1  XP_003643502.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXC66
    --
    90(a)
    1 ↔ 1
    2(72026523-72028135)
    zebrafish
    (Danio rerio)
    Actinopterygii hoxc6a1 homeo box C6a 69.43(n)
    75.98(a)
      30346  NM_131123.1  NP_571198.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Antp3 midgut development specific RNA polymerase
    II more
    70(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea lin-396
    Homeobox protein lin-39
    20(a)
    possible ortholog
    III(7528603-7536567)


    ENSEMBL Gene Tree for HOXC6 (if available)
    TreeFam Gene Tree for HOXC6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXC6 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXB52  GSX22  
    HOXC52  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  HOXA32  
    HOXD82  HOXB12  HOXB62  HOXB82  HOXD42  HOXB22  HOXB72  PDX12  
    HOXC42  
    18/20 SIMAP similar genes for HOXC6 using alignment to 4 protein entries:     HXC6_HUMAN (see all proteins) (see all similar genes):
    HOX B6    HOXA4    HOXC13    HOXB4    HOXB5    HOXC5
    HOXD4    HMX2    HOXB6    HOXA6    HOXC4    HOXA5
    PDX1    HOXA7    HOXB7    NKX6-1    HLX    HOXD8

    HOXC6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HOXC6
         1 CNV: 3890
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXC6
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HOXC6 for disorders           About GeneDecksing

    OMIM gene information: 142972    OMIM disorders: --

    16 diseases for HOXC6:    About MalaCards
    anaplastic large cell lymphoma    non-hodgkin lymphoma    b-cell lymphomas    esophageal squamous cell carcinoma
    squamous cell carcinoma    hodgkin's lymphoma    cytomegalovirus infection    myeloid leukemia
    acute leukemia    leukemia    esophagitis    osteosarcoma
    prostate cancer    carcinoma    neuroblastoma    prostatitis

    7 Novoseek disease relationships for HOXC6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chemically induced 46.6 1 7501971 (1)
    lymphoma non-hodgkins 32.4 2 9354682 (2)
    lymphoma 28.1 2 9327740 (2)
    leukemia 26.9 4 9823947 (2), 8634419 (1), 9354682 (1)
    breast cancer 5.93 3 8870653 (2)
    metastasis 0 1 17294802 (1)
    tumors 0 1 15948116 (1)


    Export disorders for HOXC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXC6 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with HOXC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a new HOXC6 transcript encoding a repressing protein. (PubMed id 8870653)1, 2, 9 Chariot A.... Gielen J. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    5. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    6. At least three human homeoboxes on chromosome 12 belong to the same transcription unit. (PubMed id 2898768)1, 2 Simeone A.... Boncinelli E. (1988)
    7. Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development. (PubMed id 2885844)1, 2 Simeone A....Peschle C. (1987)
    8. [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells] (PubMed id 19236766)1, 9 Feng J.Q....Chen S.Q. (2009)
    9. Loss of HOXC6 expression induces apoptosis in prostate cancer cells. (PubMed id 15637592)1, 9 Ramachandran S....Moreno C.S. (2005)
    10. HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. (PubMed id 17488478)1, 9 Zhang X....Moriuchi T. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3223 HGNC: 5128 AceView: HOXC6 Ensembl:ENSG00000197757 euGenes: HUgn3223
    ECgene: HOXC6 H-InvDB: HOXC6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXC6 gene:
    Search GeneIP for patents involving HOXC6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HOXC6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXC6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXC6  
     OriGene Protein Over-expression Lysate for HOXC6   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HOXC6   OriGene 3'-UTR Clone for HOXC6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HOXC6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXC6   OriGene Custom Protein Services for HOXC6  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HOXC6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXC6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXC6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXC6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXC6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXC6
     GenScript Custom Purified and Recombinant Proteins Services for HOXC6 GenScript cDNA clones with any tag delivered in your preferred vector for HOXC6
     GenScript Custom Assay Services for HOXC6 GenScript Custom Superior Antibodies Services for HOXC6
     GenScript Custom overexpressing Cell Line Services for HOXC6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXC6 promoter
     Search Chromatin IP Primers for HOXC6
     RT2 qPCR Primer Assay in human, mouse, rat HOXC6
     Search GNC Networks for HOXC6
     SABiosciences PCR Arrays including human, mouse, rat HOXC6
     Search Tocris compounds for HOXC6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HOXC6 antibodies
     HOXC6 proteins
     HOXC6 lysates
     Antibodies for HOXC6
     See all of Abcam's Antibodies, Kits and Proteins for HOXC6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HOXC6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HOXC6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC6
     SwitchGear 3'UTR luciferase reporter plasmids for HOXC6
     Browse SwitchGear Promoter luciferase reporter plasmids for HOXC6
     ThermoFisher Antibodies for HOXC6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC6
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HOXC6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4