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Aliases for HOXC6 Gene

Aliases for HOXC6 Gene

  • Homeobox C6 2 3
  • HOX3C 3 4 6
  • Homeobox Protein HHO.C8 3 4
  • Homeobox Protein Hox-3C 3 4
  • Homeobox Protein CP25 3 4
  • Homeo Box C6 2 3
  • Homeobox Protein Hox-C6 3
  • Homeo Box C8 Protein 3
  • Homeo Box 3C 3
  • HHO.C8 3
  • HOX3 3
  • CP25 3

External Ids for HOXC6 Gene

Previous Symbols for HOXC6 Gene

  • HOX3C
  • HOX3

Summaries for HOXC6 Gene

Entrez Gene Summary for HOXC6 Gene

  • This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC6 Gene

HOXC6 (Homeobox C6) is a Protein Coding gene. Diseases associated with HOXC6 include cytomegalovirus infection and b-cell lymphomas. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription corepressor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXC6 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC6 Gene

Genomics for HOXC6 Gene

Genomic Location for HOXC6 Gene

Start:
53,990,624 bp from pter
End:
54,030,823 bp from pter
Size:
40,200 bases
Orientation:
Plus strand

Genomic View for HOXC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC6 Gene

Regulatory Elements for HOXC6 Gene

Transcription factor binding sites by QIAGEN in the HOXC6 gene promoter:

Proteins for HOXC6 Gene

  • Protein details for HOXC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09630-HXC6_HUMAN
    Recommended name:
    Homeobox protein Hox-C6
    Protein Accession:
    P09630
    Secondary Accessions:
    • B2RBV2
    • Q6DK09

    Protein attributes for HOXC6 Gene

    Size:
    235 amino acids
    Molecular mass:
    26915 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HOXC6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOXC6 Gene

Proteomics data for HOXC6 Gene at MOPED

Post-translational modifications for HOXC6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys158

Other Protein References for HOXC6 Gene

No data available for DME Specific Peptides for HOXC6 Gene

Domains for HOXC6 Gene

Gene Families for HOXC6 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

UniProtKB/Swiss-Prot:

HXC6_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P09630
Family:
  • Belongs to the Antp homeobox family.:
    • P09630
genes like me logo Genes that share domains with HOXC6: view

Function for HOXC6 Gene

Molecular function for HOXC6 Gene

GENATLAS Biochemistry: homeo box C6(3C),homologous to mouse Hox-3.3,Drosophila Antp,Ubx,abd-A,expressed in first trimester trophoblast,involved in mouse anterior and posteior limb patterning,expressed in anterior and posterior limbs
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0003714 transcription corepressor activity TAS 8870653
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC6: view
genes like me logo Genes that share phenotypes with HOXC6: view

Animal Models for HOXC6 Gene

MGI Knock Outs for HOXC6:

miRNA for HOXC6 Gene

miRTarBase miRNAs that target HOXC6

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXC6 Gene

Localization for HOXC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC6 Gene COMPARTMENTS Subcellular localization image for HOXC6 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOXC6: view

Pathways for HOXC6 Gene

SuperPathways for HOXC6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8870653
GO:0007275 multicellular organismal development TAS 8870653
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXC6: view

No data available for Pathways by source for HOXC6 Gene

Transcripts for HOXC6 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC6 Gene

No ASD Table

Relevant External Links for HOXC6 Gene

GeneLoc Exon Structure for
HOXC6
ECgene alternative splicing isoforms for
HOXC6

Expression for HOXC6 Gene

mRNA expression in normal human tissues for HOXC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC6 Gene

This gene is overexpressed in Fallopian Tube (4.8) and Ovary (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOXC6 Gene

genes like me logo Genes that share expressions with HOXC6: view

Orthologs for HOXC6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXC6 36
  • 100 (n)
  • 100 (a)
HOXC6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXC6 36
  • 97.59 (n)
  • 99.57 (a)
HOXC6 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXC6 36
  • 97.73 (n)
  • 99.57 (a)
HOXC6 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxc6 36
  • 97.3 (n)
  • 100 (a)
Hoxc6 16
Hoxc6 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXC6 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC6 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxc6 36
  • 97.02 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves HOXC6 36
  • 80.27 (n)
  • 91.54 (a)
HOXC6 37
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXC6 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc6 36
  • 79.93 (n)
  • 89.55 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxc6a 36
  • 71.64 (n)
  • 79.6 (a)
hoxc6a 37
  • 69 (a)
OneToMany
hoxc6b 37
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Antp 37
  • 22 (a)
OneToMany
Antp 38
  • 70 (a)
Species with no ortholog for HOXC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC6 Gene

ENSEMBL:
Gene Tree for HOXC6 (if available)
TreeFam:
Gene Tree for HOXC6 (if available)

Paralogs for HOXC6 Gene

Selected SIMAP similar genes for HOXC6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HOXC6: view

Variants for HOXC6 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXC6 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914
nsv899102 CNV Loss 21882294
esv2672088 CNV Deletion 23128226
nsv832418 CNV Loss 17160897

Relevant External Links for HOXC6 Gene

HapMap Linkage Disequilibrium report
HOXC6

No data available for Sequence variations from dbSNP and Humsavar for HOXC6 Gene

Disorders for HOXC6 Gene

(7) Novoseek inferred disease relationships for HOXC6 Gene

Disease -log(P) Hits PubMed IDs
chemically induced 46.6 1
lymphoma non-hodgkins 32.4 2
lymphoma 28.1 2
leukemia 26.9 4
breast cancer 5.93 2
genes like me logo Genes that share disorders with HOXC6: view

No data available for UniProtKB/Swiss-Prot for HOXC6 Gene

Publications for HOXC6 Gene

  1. Cloning and expression of a new HOXC6 transcript encoding a repressing protein. (PMID: 8870653) Chariot A. … Gielen J. (Biochem. J. 1996) 3 4 23
  2. Nucleolar localisation of three Hox homeoproteins. (PMID: 7738096) Corsetti M.T. … Corte G. (J. Cell. Sci. 1995) 3 23
  3. Loss of HOXC6 expression induces apoptosis in prostate cancer cells. (PMID: 15637592) Ramachandran S. … Moreno C.S. (Oncogene 2005) 3 23
  4. HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. (PMID: 17488478) Zhang X. … Moriuchi T. (J. Cell. Mol. Med. 2007) 3 23
  5. [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells]. (PMID: 19236766) Feng J.Q. … Chen S.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 3 23

Products for HOXC6 Gene

  • Addgene plasmids for HOXC6

Sources for HOXC6 Gene

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