Aliases for HOXC6 Gene
Aliases for HOXC6 Gene
External Ids for HOXC6 Gene
- HGNC: 5128
- Entrez Gene: 3223
- Ensembl: ENSG00000197757
- OMIM: 142972
- UniProtKB: P09630
Previous HGNC Symbols for HOXC6 Gene
- HOX3C
- HOX3
Previous GeneCards Identifiers for HOXC6 Gene
- GC12M054395
- GC12P054524
- GC12P054128
- GC12P052697
- GC12P052698
- GC12P054412
- GC12P054384
- GC12P051450
Summaries for HOXC6 Gene
-
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXC6 Gene
HOXC6 (Homeobox C6) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is HOXA6.
UniProtKB/Swiss-Prot for HOXC6 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC6 Gene
Genomics for HOXC6 Gene
Regulatory Elements for HOXC6 Gene
Enhancers for HOXC6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXC6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXC6 gene promoter:
Regulatory Element Products
Genomic Location for HOXC6 Gene
- Chromosome:
- 12
- Start:
- 53,990,624 bp from pter
- End:
- 54,030,823 bp from pter
- Size:
- 40,200 bases
- Orientation:
- Plus strand
Genomic View for HOXC6 Gene
Genes around HOXC6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
HOXC6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXC6 Gene
Proteins for HOXC6 Gene
-
Protein details for HOXC6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09630-HXC6_HUMAN
- Recommended name:
- Homeobox protein Hox-C6
- Protein Accession:
- P09630
- B2RBV2
- Q6DK09
Protein attributes for HOXC6 Gene
- Size:
- 235 amino acids
- Molecular mass:
- 26915 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXC6 Gene
Post-translational modifications for HOXC6 Gene
Other Protein References for HOXC6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOXC6
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- Invitrogen Antibodies for HOXC6
- antibodies-online Antibodies for HOXC6: See all 62
- GeneTex HOXC6 antibody for HOXC6
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXC6
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXC6
- Origene Custom Protein Services for HOXC6
- antibodies-online Proteins for HOXC6: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXC6
Assay Products
No data available for DME Specific Peptides for HOXC6 Gene
Domains & Families for HOXC6 Gene
Gene Families for HOXC6 Gene
Protein Domains for HOXC6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXC6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P09630- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXC6 Gene
Molecular function for HOXC6 Gene
- GENATLAS Biochemistry:
- homeo box C6(3C),homologous to mouse Hox-3.3,Drosophila Antp,Ubx,abd-A,expressed in first trimester trophoblast,involved in mouse anterior and posteior limb patterning,expressed in anterior and posterior limbs
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0003714 | transcription corepressor activity | TAS | 8870653 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXC6 Gene
- MGI mutant phenotypes for HOXC6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXC6:
Animal Models for HOXC6 Gene
- MGI Knock Outs for HOXC6:
-
- Hoxc6 tm1Dds
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXC6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC6 gene
- Search ViGene Biosciences for HOXC6
CRISPR Products
-
OriGene CRISPR knockouts for HOXC6
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC6
- GenScript: Design CRISPR guide RNA sequences for HOXC6
miRNA for HOXC6 Gene
- miRTarBase miRNAs that target HOXC6
-
- hsa-mir-335-5p (MIRT017144)
- hsa-mir-128-3p (MIRT021916)
- hsa-mir-27a-3p (MIRT028721)
- hsa-mir-6763-5p (MIRT502219)
- hsa-mir-3150a-3p (MIRT502220)
- hsa-mir-491-5p (MIRT502221)
- hsa-mir-6769b-5p (MIRT502222)
- hsa-mir-6769a-5p (MIRT502223)
- hsa-mir-92a-2-5p (MIRT502224)
- hsa-mir-654-5p (MIRT502225)
- hsa-mir-6825-5p (MIRT502226)
- hsa-mir-541-3p (MIRT502227)
- hsa-mir-939-5p (MIRT502228)
- hsa-mir-1343-5p (MIRT502229)
- hsa-mir-3175 (MIRT502230)
- hsa-mir-6090 (MIRT502231)
- hsa-mir-8085 (MIRT502232)
- hsa-mir-6731-5p (MIRT502233)
- hsa-mir-6878-5p (MIRT502234)
- hsa-mir-4644 (MIRT502235)
- hsa-mir-4306 (MIRT502236)
- hsa-mir-6133 (MIRT502237)
- hsa-mir-185-5p (MIRT502238)
- hsa-mir-6130 (MIRT502239)
- hsa-mir-6129 (MIRT502240)
- hsa-mir-6127 (MIRT502241)
- hsa-mir-4510 (MIRT502242)
- hsa-mir-4419a (MIRT502243)
- hsa-mir-5681a (MIRT502244)
- hsa-mir-6760-5p (MIRT502245)
- hsa-mir-6856-5p (MIRT502246)
- hsa-mir-6758-5p (MIRT502247)
miRNA Products
- Search ViGene Biosciences for HOXC6
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXC6
- Browse OriGene Inhibitory RNA Products For HOXC6
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
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Cell Line Products
-
Horizon Cell Lines for HOXC6
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXC6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXC6 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC6 Gene
Localization for HOXC6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXC6 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HOXC6 Gene
No Data Available
Interacting Proteins for HOXC6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | TAS | 8870653 |
| GO:0007275 | multicellular organism development | TAS | 8870653 |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXC6 Gene
Transcripts for HOXC6 Gene
mRNA/cDNA for HOXC6 Gene
- (2) REFSEQ mRNAs :
- (228) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXC6
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC6
- GenScript: Design CRISPR guide RNA sequences for HOXC6
miRNA Products
- Search ViGene Biosciences for HOXC6
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXC6
- Browse OriGene Inhibitory RNA Products For HOXC6
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC6 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXC6
Flow Cytometry Products
Expression for HOXC6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Spinal Cord (Nervous System)
- Lateral Motor Neurons Rostral Brachial Lateral Motor Column
- Lateral Motor Neurons Caudal Brachial Lateral Motor Column
- Motor neuron-like cells(Hester ME et. al. 2011)
- Lateral motor column neuron-like cells(Amoroso MW et. al. 2013)
- Motor neuron progenitors(Corti S et. al. 2009)
-
Neurons
- Lateral Motor Neurons Rostral Brachial Lateral Motor Column
- Lateral Motor Neurons Caudal Brachial Lateral Motor Column
- Motor neuron-like cells(Hester ME et. al. 2011)
- Lateral motor column neuron-like cells(Amoroso MW et. al. 2013)
- Motoneuron-like cells(Lee H et. al. 2007)
- Motor Neurons (Nervous System)
-
Bone (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
- Detroit 551
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
- Detroit 551
- Adipose (Muscoskeletal System)
-
Heart (Cardiovascular System)
- Atrioventricular Canal Cells Atrioventricular Canal
-
Somite (Muscoskeletal System)
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
- Neural Tube (Nervous System)
- Kidney (Urinary System)
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HOXC6 Gene
This gene is overexpressed in Fallopian Tube (x4.8) and Ovary (x4.8).
This gene is overexpressed in Pancreatic juice (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXC6 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXC6 Gene:
HOXC6Evidence on tissue expression from TISSUES for HOXC6 Gene
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for HOXC6
-
OriGene qPCR primer pairs for HOXC6
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC6 Gene
Orthologs for HOXC6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXC6 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXC6 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXC6 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxc6 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxc6 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXC6 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXC6 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXC6 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXC6 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxc6 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxc6b 35 |
|
OneToMany | |
| hoxc6a 34 35 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Antp 36 35 |
|
- Species where no ortholog for HOXC6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXC6 Gene
Paralogs for HOXC6 Gene
(19) SIMAP similar genes for HOXC6 Gene using alignment to 4 proteins:
Variants for HOXC6 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000059230 | -- | 54,014,986(+) | TCAAA(A/G)TGGCT | upstream-variant-2KB | |
| rs1000137595 | -- | 54,028,295(+) | TTACT(G/T)TCAAA | intron-variant, upstream-variant-2KB | |
| rs1000191769 | -- | 54,028,030(+) | CTTCC(C/G)TTGGA | intron-variant, upstream-variant-2KB | |
| rs1000269134 | -- | 54,022,527(+) | TCTCT(C/T)TTTGC | intron-variant | |
| rs1000413505 | -- | 54,015,245(+) | CGTCC(C/T)GAAGG | upstream-variant-2KB |
Residual Variation Intolerance Score:
59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.10;
22.31% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXC6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXC6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC6 Gene
Disorders for HOXC6 Gene
Relevant External Links for HOXC6
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HOXC6
No disorders were found for HOXC6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC6 Gene
Publications for HOXC6 Gene
- Cloning and expression of a new HOXC6 transcript encoding a repressing protein. (PMID: 8870653) Chariot A. … Gielen J. (Biochem. J. 1996) 3 4 22 64
- [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells]. (PMID: 19236766) Feng J.Q. … Chen S.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 3 22 64
- HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. (PMID: 17488478) Zhang X. … Moriuchi T. (J. Cell. Mol. Med. 2007) 3 22 64
- Loss of HOXC6 expression induces apoptosis in prostate cancer cells. (PMID: 15637592) Ramachandran S. … Moreno C.S. (Oncogene 2005) 3 22 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for HOXC6 Gene
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- Novus Biologicals Antibodies for HOXC6
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- antibodies-online Antibodies for HOXC6: See all 62
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- antibodies-online Proteins for HOXC6: See all 10
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- GeneTex HOXC6 antibody for HOXC6
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXC6 gene
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- VectorBuilder custom plasmid, inducible vectors for HOXC6
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXC6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer