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HOXC6 Gene

protein-coding   GIFtS: 49
GCID: GC12P054384

Homeobox C6

(Previous name: homeo box C6)
(Previous symbols: HOX3C, HOX3)
  See HOXC6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox C61 2     Homeobox Protein Hox-3C2 3
HOX3C1 2 3 5     CP252
HOX31 2     HHO.C82
Homeo Box C61 2     Homeo Box 3C2
Homeobox Protein CP252 3     Homeo Box C8 Protein2
Homeobox Protein HHO.C82 3     Homeobox Protein Hox-C62

External Ids:    HGNC: 51281   Entrez Gene: 32232   Ensembl: ENSG000001977577   OMIM: 1429725   UniProtKB: P096303   

Export aliases for HOXC6 gene to outside databases

Previous GC identifers: GC12M054395 GC12P054524 GC12P054128 GC12P052697 GC12P052698 GC12P054412 GC12P051450


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXC6 Gene:
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription
factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar
homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to
11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome
12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon
spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced
transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes
the shared exon, and transcript variant one includes only gene-specific exons. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXC6 Gene:
HOXC6 (homeobox C6) is a protein-coding gene. Diseases associated with HOXC6 include cytomegalovirus infection, and b-cell lymphomas. GO annotations related to this gene include transcription corepressor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot: HXC6_HUMAN, P09630
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HOXC6 gene promoter:
         Pax-5   Sp1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HOXC6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXC6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054384:  view genomic region     (about GC identifiers)

Start:
54,384,408 bp from pter      End:
54,424,607 bp from pter
Size:
40,200 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HXC6_HUMAN, P09630 (See protein sequence)
Recommended Name: Homeobox protein Hox-C6  
Size: 235 amino acids; 26915 Da
Secondary accessions: B2RBV2 Q6DK09
Alternative splicing: 2 isoforms:  P09630-1   P09630-2   

Explore the universe of human proteins at neXtProt for HOXC6: NX_P09630

Explore proteomics data for HOXC6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys158
  • Modification sites at PhosphoSitePlus

  • See HOXC6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004494.1  NP_710160.1  

    ENSEMBL proteins: 
     ENSP00000424124   ENSP00000423898   ENSP00000377864   ENSP00000243108  

    HOXC6 Human Recombinant Protein Products:

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    Novus Biologicals HOXC6 Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXC6

     
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    antibodies-online proteins for HOXC6 (8 products) 

     
    antibodies-online peptides for HOXC6

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    antibodies-online antibodies for HOXC6 (49 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5 InterPro protein domains:
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P09630

    ProtoNet protein and cluster: P09630

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXC6_HUMAN, P09630
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with HOXC6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXC6_HUMAN, P09630
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXC6:
    homeo box C6(3C),homologous to mouse Hox-3.3,Drosophila Antp,Ubx,abd-A,expressed in first trimester
    trophoblast,involved in mouse anterior and posteior limb patterning,expressed in anterior and posterior limbs

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0003714transcription corepressor activity TAS8870653
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with HOXC6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXC6:
     Increased number of cells in m 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hoxc6):
     endocrine/exocrine gland  integument  skeleton 

    Find genes that share phenotypes with HOXC6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Hoxc6tm1Dds for HOXC6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXC6
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    miRNA
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    miRTarBase miRNAs that target HOXC6:
    hsa-mir-27a-3p (MIRT028721), hsa-mir-335-5p (MIRT017144), hsa-mir-128-3p (MIRT021916)

    Block miRNA regulation of human, mouse, rat HOXC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC6 (see all 18):
    hsa-miR-892b hsa-miR-642a hsa-miR-1321 hsa-miR-4328 hsa-miR-128 hsa-miR-3074-3p hsa-miR-486-3p hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidHOXC6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXC6
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): HOXC6 (NM_004503)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC6
    Addgene plasmids for HOXC6 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXC6_HUMAN, P09630: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with HOXC6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXC6: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXC6

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for HOXC6 (P096303 ENSP000002431084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PBX3P404263, ENSP000003625884I2D: score=1 STRING: ENSP00000362588
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    JUNDP175353I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8870653
    GO:0007275multicellular organismal development TAS8870653
    GO:0009952anterior/posterior pattern specification IEA--

    Find genes that share ontologies with HOXC6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXC6 (HXC6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOXC6 gene (2 alternative transcripts): 
    NM_004503.3  NM_153693.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504315 ENST00000509328 ENST00000394331(uc001ses.3) ENST00000243108(uc001sev.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXC6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC6 (see all 18):
    hsa-miR-892b hsa-miR-642a hsa-miR-1321 hsa-miR-4328 hsa-miR-128 hsa-miR-3074-3p hsa-miR-486-3p hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidHOXC6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXC6
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC6
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    GenScript: all cDNA clones in your preferred vector (see all 2): HOXC6 (NM_004503)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC6
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    Addgene plasmids for HOXC6 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC6
      QuantiTect SYBR Green Assays in human, mouse, rat HOXC6
      QuantiFast Probe-based Assays in human, mouse, rat HOXC6

    Selected AceView cDNA sequences (see all 228):

    AI215607 BF434131 BM127322 BM127627 CR615968 AA827833 AL558161 CR622939 
    AI631879 CR600861 BQ684698 BX280842 CA432146 BF197458 BQ949038 AI380130 
    T28272 BE464190 BC074845 AI200419 NM_153693 NM_153633 BQ890449 BF058345 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXC6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACCTGCTG
    HOXC6 Expression
    About this image


    HOXC6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Spinal Cord (Nervous System)    fully expand to see all 6 entries
             Lateral Motor Neurons Rostral Brachial Lateral Motor Column
             Motor neuron progenitors
     
     Neurons
             Lateral Motor Neurons Rostral Brachial Lateral Motor Column
             Lateral motor column neuron-like cells
     
     Motor Neurons (Nervous System)    fully expand to see all 3 entries
             Lateral motor column neuron-like cells
     
     Cartilage (Muscoskeletal System)
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
     
     Somite (Muscoskeletal System)
             Thoracic Sclerotome Cells Thoracic Mesenchymal Sclerotome
    HOXC6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXC6 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXC6: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOXC6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxc61 , 5 homeobox C61, 5 97.3(n)1
    100(a)1
      15 (58.06 cM)5
    154251  NM_010465.21  NP_034595.21 
     1029982575 
    chicken
    (Gallus gallus)
    Aves HOXC61 homeobox C6 80.27(n)
    91.54(a)
      100858368  XM_003643454.2  XP_003643502.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXC66
    homeobox C6
    89(a)
    1 ↔ 1
    2(72026523-72028135)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hoxc61 homeobox C6 79.93(n)
    89.55(a)
      101733663  XM_004911934.1  XP_004911991.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxc6a1 homeo box C6a 71.64(n)
    79.6(a)
      30346  NM_131123.1  NP_571198.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Antp3 midgut development specific RNA
    polymerase II more
    70(a)     --


    ENSEMBL Gene Tree for HOXC6 (if available)
    TreeFam Gene Tree for HOXC6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXC6 gene
    HOXA72  HOXB52  HOXC52  HOXB42  HOXA52  ENSG000002732662  HOXA42  HOXC82  
    HOXA62  ENSG000002730492  HOXD82  HOXB62  HOXB82  HOXD42  HOXB72  HOXC42  
    Selected SIMAP similar genes for HOXC6 using alignment to 4 protein entries:     HXC6_HUMAN (see all proteins) (see all similar genes):
    HOX B6    HOXA4    HOXC13    HOXB4    HOXB5    HOXC5
    HOXD4    HMX2    HOXB6    HOXA6    HOXC4    HOXA5
    PDX1    HOXA7    HOXB7    HLX    HOXD8    HOXB1

    Find genes that share paralogs with HOXC6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOXC6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672088CNV Deletion23128226
    nsv899102CNV Loss21882294
    nsv832418CNV Loss17160897
    nsv899100CNV Loss21882294
    nsv826379CNV Gain20364138
    nsv428282CNV Gain18775914
    dgv512e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXC6
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXC6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142972    OMIM disorders: --

    3 diseases for HOXC6:    
    About MalaCards
    cytomegalovirus infection    b-cell lymphomas    esophageal squamous cell carcinoma


    Find genes that share disorders with HOXC6           About GenesLikeMe

    7 Novoseek inferred disease relationships for HOXC6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chemically induced 46.6 1 7501971 (1)
    lymphoma non-hodgkins 32.4 2 9354682 (2)
    lymphoma 28.1 2 9327740 (2)
    leukemia 26.9 4 9823947 (2), 8634419 (1), 9354682 (1)
    breast cancer 5.93 3 8870653 (2)
    metastasis 0 1 17294802 (1)
    tumors 0 1 15948116 (1)


    Export disorders for HOXC6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXC6 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with HOXC6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a new HOXC6 transcript encoding a repressing protein. (PubMed id 8870653)1, 2, 9 Chariot A.... Gielen J. (Biochem. J. 1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    5. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
    6. At least three human homeoboxes on chromosome 12 belong to the same transcription unit. (PubMed id 2898768)1, 2 Simeone A.... Boncinelli E. (Nucleic Acids Res. 1988)
    7. Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development. (PubMed id 2885844)1, 2 Simeone A....Peschle C. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    8. [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells]. (PubMed id 19236766)1, 9 Feng J.Q....Chen S.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    9. Loss of HOXC6 expression induces apoptosis in prostate cancer cells. (PubMed id 15637592)1, 9 Ramachandran S....Moreno C.S. (Oncogene 2005)
    10. HOXC6 and HOXC11 increase transcription of S100beta gene in BrdU-induced in vitro differentiation of GOTO neuroblastoma cells into Schwannian cells. (PubMed id 17488478)1, 9 Zhang X....Moriuchi T. (J. Cell. Mol. Med. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3223 HGNC: 5128 AceView: HOXC6 Ensembl:ENSG00000197757 euGenes: HUgn3223
    ECgene: HOXC6 H-InvDB: HOXC6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXC6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXC6 gene:
    Search GeneIP for patents involving HOXC6

    GeneCards and IP:
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