Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HOXC5 Gene

protein-coding   GIFtS: 50
GCID: GC12P054471

Homeobox C5

(Previous name: homeo box C5)
(Previous symbols: HOX3D, HOX3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Homeobox C51 2     Homeobox Protein CP112 3
HOX3D1 2 3 5     Homeobox Protein Hox-3D2 3
HOX31 2     CP112
Homeo Box C51 2     Homeobox Protein Hox-C52

External Ids:    HGNC: 51271   Entrez Gene: 32222   Ensembl: ENSG000001727897   OMIM: 1429735   UniProtKB: Q004443   
ORGUL members:         

Export aliases for HOXC5 gene to outside databases

Previous GC identifers: GC12M054391 GC12P054539 GC12P054129 GC12P052713 GC12P054411 GC12P054379 GC12P051449


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HOXC5 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC
genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon.
Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the
gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant
which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant
contains gene-specific exons only. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXC5 Gene:
HOXC5 (homeobox C5) is a protein-coding gene. Diseases associated with HOXC5 include hodgkin's lymphoma, and non-hodgkin lymphoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA6.

UniProtKB/Swiss-Prot: HXC5_HUMAN, Q00444
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXC5 gene promoter:
         Egr-3   Pax-5   Sp1   FOXL1   c-Ets-1   Egr-4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HOXC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC5 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054471:  view genomic region     (about GC identifiers)

Start:
54,410,642 bp from pter      End:
54,429,145 bp from pter
Size:
18,504 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HXC5_HUMAN, Q00444 (See protein sequence)
Recommended Name: Homeobox protein Hox-C5  
Size: 222 amino acids; 24976 Da

Explore the universe of human proteins at neXtProt for HOXC5: NX_Q00444

Explore proteomics data for HOXC5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys172
  • Modification sites at PhosphoSitePlus

  • See HOXC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061826.1  
    ENSEMBL proteins: 
     ENSP00000309336  

    HOXC5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HOXC5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HOXC5
    GenScript Custom Purified and Recombinant Proteins Services for HOXC5
    Novus Biologicals HOXC5 Proteins
    Novus Biologicals HOXC5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXC5

    HOXC5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HOXC5
    Novus Biologicals HOXC5 Antibodies
    Abcam antibodies for HOXC5
    Cloud-Clone Corp. Antibodies for HOXC5
    Search ThermoFisher Antibodies for HOXC5
    LSBio Antibodies in human, mouse, rat for HOXC5

    HOXC5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HOXC5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXC5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HOXC5
    Cloud-Clone Corp. CLIAs for HOXC5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry Q00444

    ProtoNet protein and cluster: Q00444

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXC5_HUMAN, Q00444
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXC5_HUMAN, Q00444
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXC5:
    homeo box C5(3D),homologous to mouse Hox-3.4,Drosophila antp,Ubx,abd-A ,expressed in first trimester
    trophoblast,involved in mouse anterior limb patterning, expressed in anterior limb

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXC5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HOXC5:
     Decreased BPV1 E2 protein expr  Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hoxc5):
     skeleton 

    HOXC5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hoxc5tm1Mrc for HOXC5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXC5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXC5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXC5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXC5

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat HOXC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC5 (see all 18):
    hsa-miR-185* hsa-miR-4288 hsa-miR-518e hsa-miR-632 hsa-miR-3121-3p hsa-miR-4273 hsa-miR-190 hsa-miR-1231
    SwitchGear 3'UTR luciferase reporter plasmidHOXC5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXC5
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HOXC5

    Clone
    Products:
         
    OriGene clones in human, mouse for HOXC5 (see all 6)
    OriGene ORF clones in mouse, rat for HOXC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXC5 (NM_018953)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HOXC5
    Browse ESI BIO Cell Lines and PureStem Progenitors for HOXC5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HXC5_HUMAN, Q00444: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0030054cell junction IDA--

    HOXC5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXC5: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXC5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    3 Interacting proteins for HOXC5 (Q004443 ENSP000003093364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PBX1P404243, ENSP000004058904I2D: score=1 STRING: ENSP00000405890
    PBX3P404263I2D: score=1 
    POLR2IP369543I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS1346761
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0048706embryonic skeletal system development IEA--

    HOXC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXC5 (HXC5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HOXC5 gene: 
    NM_018953.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312492(uc001sew.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXC5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC5 (see all 18):
    hsa-miR-185* hsa-miR-4288 hsa-miR-518e hsa-miR-632 hsa-miR-3121-3p hsa-miR-4273 hsa-miR-190 hsa-miR-1231
    SwitchGear 3'UTR luciferase reporter plasmidHOXC5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXC5
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC5
    Clone
    Products:
         
    OriGene clones in human, mouse for HOXC5 (see all 6)
    OriGene ORF clones in mouse, rat for HOXC5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXC5 (NM_018953)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC5
      QuantiTect SYBR Green Assays in human, mouse, rat HOXC5
      QuantiFast Probe-based Assays in human, mouse, rat HOXC5

    Selected AceView cDNA sequences (see all 228):

    T28272 AI380130 AW469953 BC074844 AW000987 BU501253 BE464190 BE396026 
    NM_014620 BM832772 AA888101 AI174335 AA158947 BM836024 AI159844 BF434950 
    BQ949038 AA629181 AI275813 NM_004503 AI200419 NM_153693 NM_153633 BQ890449 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HOXC5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HOXC5 Expression
    About this image


    HOXC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Neurons
             Lateral Motor Neurons Rostral Brachial Lateral Motor Column
             Motor neuron-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 4 entries
             Lateral Motor Neurons Rostral Brachial Lateral Motor Column
             Motor neuron-like cells
     
     Motor Neurons (Nervous System)
             Motor neuron-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Spinal Ventral Columns
     
     Limb (Muscoskeletal System)
             Limb Bud Mesenchyme Cells Limb Bud
    HOXC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXC5 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXC5: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXC5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC5
    QuantiTect SYBR Green Assays in human, mouse, rat HOXC5
    QuantiFast Probe-based Assays in human, mouse, rat HOXC5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HOXC5 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxc51 , 5 homeobox C51, 5 98.5(n)1
    99.55(a)1
      15 (58.07 cM)5
    154241  NM_175730.51  NP_783857.11 
     1029674435 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    65(a)
    1 → many
    2(72020531-72022726)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hoxc51 homeobox C5 73.94(n)
    73.64(a)
      100487879  XM_002936649.2  XP_002936695.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxc5a1 homeo box C5a 58.45(n)
    57.99(a)
      30379  NM_131144.1  NP_571219.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Scr3 midgut development specific RNA
    polymerase II more
    75(a)   3 84A5   --


    ENSEMBL Gene Tree for HOXC5 (if available)
    TreeFam Gene Tree for HOXC5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HOXC5 gene
    HOXA62  HOXC82  ENSG000002730492  HOXD82  HOXA72  HOXB62  HOXB52  HOXC62  
    HOXB82  HOXB42  HOXA52  ENSG000002732662  HOXD42  HOXA42  HOXB72  HOXC42  
    14 SIMAP similar genes for HOXC5 using alignment to 1 protein entry:     HXC5_HUMAN:
    HOXC6    HOXA4    HOXA-9    HOXA5    HOXB6    HOXD4
    HOXD8    HOXB5    HOXB7    HOXA7    HOXB8    HOXC8
    HOXD9    HOXA6

    HOXC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOXC5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672088CNV Deletion23128226
    nsv899102CNV Loss21882294
    nsv832418CNV Loss17160897
    nsv899100CNV Loss21882294
    nsv826379CNV Gain20364138
    nsv428282CNV Gain18775914
    dgv512e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXC5
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXC5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 142973    OMIM disorders: --

    8 diseases for HOXC5:    
    About MalaCards
    hodgkin's lymphoma    non-hodgkin lymphoma    anaplastic large cell lymphoma    b-cell lymphomas
    myeloid leukemia    thyroiditis    leukemia    neuronitis


    HOXC5 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for HOXC5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma t-cell 54.4 6 9327740 (3), 9354682 (1)
    lymphoma non-hodgkins 48.4 4 9354682 (2), 9327740 (1)
    leukemia 35.6 5 8634419 (3), 9823947 (2)
    lymphoma 24.7 11 9327740 (5), 9354682 (1)

    Genetic Association Database (GAD): HOXC5
    Human Genome Epidemiology (HuGE) Navigator: HOXC5 (1 document)

    Export disorders for HOXC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HOXC5 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with HOXC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The upstream region of the human homeobox gene HOX3D is a target for regulation by retinoic acid and HOX homeoproteins. (PubMed id 1346761)1, 2, 9 Arcioni L....Mavilio F. (EMBO J. 1992)
    2. Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. (PubMed id 16215934)1, 4, 9 Gong L.G....Sun K.L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    5. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
    6. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (Nat. Genet. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3222 HGNC: 5127 AceView: HOXC6 Ensembl:ENSG00000172789 euGenes: HUgn3222
    ECgene: HOXC5 H-InvDB: HOXC5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HOXC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HOXC5 gene:
    Search GeneIP for patents involving HOXC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HOXC5  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for HOXC5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HOXC5  
     OriGene qSTAR qPCR primer pairs in human, mouse for HOXC5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HOXC5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXC5   OriGene Custom Protein Services for HOXC5  

     
     
     Block miRNA regulation of human, mouse, rat HOXC5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HOXC5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXC5 Predesigned siRNA for gene silencing in human, mouse, rat HOXC5
     QuantiFast Probe-based Assays in human, mouse, rat HOXC5 QuantiTect SYBR Green Assays in human, mouse, rat HOXC5
     PCR Arrays including human, mouse, rat HOXC5 Search Chromatin IP Primers for HOXC5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC5  Search GeneGlobe Interaction Network for HOXC5
     Regulatory tfbs in HOXC5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HOXC5 GenScript cDNA clones with any tag delivered in your preferred vector for HOXC5
     GenScript Custom Assay Services for HOXC5 GenScript Custom overexpressing Cell Line Services for HOXC5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HOXC5 (HXC5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HOXC5 antibodies
     HOXC5 proteins
     HOXC5 lysates
     Antibodies for HOXC5
     See all of Abcam's Antibodies, Kits and Proteins for HOXC5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HOXC5
     Antibodies for HOXC5
     ELISAs for HOXC5
     CLIAs for HOXC5



     Browse ESI BIO Cell Lines and PureStem Progenitors for HOXC5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC5
     SwitchGear 3'UTR luciferase reporter plasmids for HOXC5
     Browse SwitchGear Promoter luciferase reporter plasmids for HOXC5
     Search ThermoFisher Antibodies for HOXC5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXC5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXC5
     LSBio Antibodies in human, mouse, rat for HOXC5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HOXC5 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4