Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HOXC5 Gene

Aliases for HOXC5 Gene

  • Homeobox C5 2 3
  • Homeobox Protein Hox-3D 3 4
  • Homeobox Protein CP11 3 4
  • Homeo Box C5 2 3
  • HOX3D 3 4
  • CP11 3
  • HOX3 3

External Ids for HOXC5 Gene

Previous HGNC Symbols for HOXC5 Gene

  • HOX3D
  • HOX3

Previous GeneCards Identifiers for HOXC5 Gene

  • GC12M054391
  • GC12P054539
  • GC12P054129
  • GC12P052713
  • GC12P054411
  • GC12P054379
  • GC12P051449
  • GC12P054471

Summaries for HOXC5 Gene

Entrez Gene Summary for HOXC5 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC5 Gene

HOXC5 (Homeobox C5) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXC5 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC5 Gene

Genomics for HOXC5 Gene

Regulatory Elements for HOXC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXC5 Gene

Chromosome:
12
Start:
54,016,852 bp from pter
End:
54,035,361 bp from pter
Size:
18,510 bases
Orientation:
Plus strand

Genomic View for HOXC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC5 Gene

Proteins for HOXC5 Gene

  • Protein details for HOXC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00444-HXC5_HUMAN
    Recommended name:
    Homeobox protein Hox-C5
    Protein Accession:
    Q00444

    Protein attributes for HOXC5 Gene

    Size:
    222 amino acids
    Molecular mass:
    24976 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC5 Gene

Proteomics data for HOXC5 Gene at MOPED

Post-translational modifications for HOXC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC5 Gene

Domains & Families for HOXC5 Gene

Gene Families for HOXC5 Gene

Suggested Antigen Peptide Sequences for HOXC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00444

UniProtKB/Swiss-Prot:

HXC5_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXC5: view

Function for HOXC5 Gene

Molecular function for HOXC5 Gene

GENATLAS Biochemistry:
homeo box C5(3D),homologous to mouse Hox-3.4,Drosophila antp,Ubx,abd-A ,expressed in first trimester trophoblast,involved in mouse anterior limb patterning, expressed in anterior limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC5: view
genes like me logo Genes that share phenotypes with HOXC5: view

Animal Models for HOXC5 Gene

MGI Knock Outs for HOXC5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for HOXC5 Gene

Localization for HOXC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC5 Gene COMPARTMENTS Subcellular localization image for HOXC5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with HOXC5: view

Pathways & Interactions for HOXC5 Gene

SuperPathways for HOXC5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Homeobox (HOX) Genes in human,mouse,rat
    • Stem Cell Transcription Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for HOXC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 1346761
GO:0009952 anterior/posterior pattern specification IEA --
GO:0048706 embryonic skeletal system development IEA --
genes like me logo Genes that share ontologies with HOXC5: view

No data available for Pathways by source and SIGNOR curated interactions for HOXC5 Gene

Drugs & Compounds for HOXC5 Gene

No Compound Related Data Available

Transcripts for HOXC5 Gene

mRNA/cDNA for HOXC5 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC5 Gene

No ASD Table

Relevant External Links for HOXC5 Gene

GeneLoc Exon Structure for
HOXC5
ECgene alternative splicing isoforms for
HOXC5

Expression for HOXC5 Gene

mRNA expression in normal human tissues for HOXC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC5 Gene

This gene is overexpressed in Fallopian Tube (x6.5) and Ovary (x4.2).
genes like me logo Genes that share expression patterns with HOXC5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HOXC5 Gene

Orthologs for HOXC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXC5 35
  • 98.5 (n)
  • 99.1 (a)
dog
(Canis familiaris)
Mammalia HOXC5 35
  • 97.45 (n)
  • 96.4 (a)
mouse
(Mus musculus)
Mammalia Hoxc5 35
  • 98.5 (n)
  • 99.55 (a)
Hoxc5 16
Hoxc5 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXC5 35
  • 97.11 (n)
  • 96.8 (a)
HOXC5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxc5 35
  • 98.5 (n)
  • 99.55 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc5 35
  • 73.94 (n)
  • 73.64 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxc5a 35
  • 58.45 (n)
  • 57.99 (a)
hoxc5a 36
  • 54 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Scr 37
  • 75 (a)
ftz 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToMany
Species with no ortholog for HOXC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC5 Gene

ENSEMBL:
Gene Tree for HOXC5 (if available)
TreeFam:
Gene Tree for HOXC5 (if available)

Paralogs for HOXC5 Gene

(14) SIMAP similar genes for HOXC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXC5: view

Variants for HOXC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXC5 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914
nsv899102 CNV Loss 21882294
esv2672088 CNV Deletion 23128226
nsv832418 CNV Loss 17160897

Variation tolerance for HOXC5 Gene

Residual Variation Intolerance Score: 45.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXC5 Gene

HapMap Linkage Disequilibrium report
HOXC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HOXC5 Gene

Disorders for HOXC5 Gene

Relevant External Links for HOXC5

Genetic Association Database (GAD)
HOXC5
Human Genome Epidemiology (HuGE) Navigator
HOXC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXC5
genes like me logo Genes that share disorders with HOXC5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC5 Gene

Publications for HOXC5 Gene

  1. Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. (PMID: 16215934) Gong L.G. … Sun K.L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005) 23 67
  2. Differentiation and cell-type-restricted expression of HOXC4, HOXC5 and HOXC6 in myeloid leukemias and normal myeloid cells. (PMID: 9823947) Bijl J.J. … Meijer C.J. (Leukemia 1998) 23 67
  3. HOXC4, HOXC5, and HOXC6 expression in non-Hodgkin's lymphoma: preferential expression of the HOXC5 gene in primary cutaneous anaplastic T-cell and oro-gastrointestinal tract mucosa-associated B-cell lymphomas. (PMID: 9354682) Bijl J.J. … Meijer C.J. (Blood 1997) 23 67
  4. HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas. (PMID: 9327740) Bijl J.J. … Meijer C.J. (Am. J. Pathol. 1997) 23 67
  5. Expression of HOXC4, HOXC5, and HOXC6 in human lymphoid cell lines, leukemias, and benign and malignant lymphoid tissue. (PMID: 8634419) Bijl J. … Meijer C.J. (Blood 1996) 23 67

Products for HOXC5 Gene

Sources for HOXC5 Gene

Back to Top

Content