HOXC4 Gene

Aliases
for HOXC4 gene

Previous GC identifers: GC12M054370 GC12P054523 GC12P054127 GC12P052696 GC12P051448

Summaries
for HOXC4 gene

Genomic Views
for HOXC4 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_029419.12  

SwitchGear Promoter luciferase reporter plasmid: HOXC4 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXC4

HOXC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054410:  view genomic region     (about GC identifiers)

Proteins
for HOXC4 gene

Explore the universe of human proteins at neXtProt for HOXC4: NX_P09017

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): HOXC4 OriGene Custom Protein Services for HOXC4
	GenScript Custom Purified and Recombinant Proteins Services for HOXC4
	Novus Biologicals HOXC4 Proteins Novus Biologicals HOXC4 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HOXC4

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HOXC4
	GenScript Custom Superior Antibodies Services for HOXC4
	Novus Biologicals HOXC4 Antibodies
	Search for Antibodies for HOXC4 at Abcam
	Uscn Antibodies for HOXC4
	Search ThermoFisher Antibodies for HOXC4

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HOXC4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HOXC4

Protein Domains /
Families
for HOXC4 gene

ProtoNet protein and cluster: P09017

Function
for HOXC4 gene

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXC4
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC4 (see all 34):
		hsa-miR-25 hsa-miR-765 hsa-miR-632 hsa-miR-29b-1* hsa-miR-23a hsa-miR-92b hsa-miR-4273 hsa-miR-92a
		SwitchGear 3'UTR luciferase reporter plasmid: HOXC4 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXC4 (see all 7) OriGene shRNA RFP: HOXC4 OriGene siRNA: HOXC4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXC4

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HOXC4

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC4 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXC4 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): HOXC4 (NM_014620)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC4
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC4

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HOXC4
		Search LifeMap BioReagents cell lines for HOXC4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC4

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Hoxc4)

Pathways & Interactions
for HOXC4 gene

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for HOXC4 gene

Transcripts
for HOXC4 gene

Expression
for HOXC4 gene

HOXC4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

10/11 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 11)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Spinal CordCaudal Brachial Lateral Motor ColumnLateral Motor Neurons			Motor Neurons
	Spinal CordCaudal Brachial Lateral Motor DivisionAnterior Latissimus Dorsi Muscle Motor Neurons			Motor Neurons
	Spinal CordCaudal Brachial Medial Motor DivisionFlexor Carpi Ulnaris Muscle Motor Neurons			Motor Neurons
	Spinal CordCaudal Brachial Medial Motor DivisionPectoralis Muscle Motor Neurons			Motor Neurons
	Spinal CordRostral Brachial Lateral Motor ColumnLateral Motor Neurons			Motor Neurons
	AdiposeCervical Brown Adipose DepotCervical Brown Adipocyte Cells			Adipose
	AdiposeLumbar Brown Adipose DepotLumbar Brown Adipocyte Cells			Adipose
	AdiposeSacral Brown Adipose DepotSacral Brown Adipocyte Cells			Adipose
	AdiposeThoracic Brown Adipose DepotThoracic Brown Adipocyte Cells			Adipose
	KidneyMetanephric MesenchymeMetanephric Mesenchyme Cells			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Posterior foregut-like cells (A scalable, suspensi...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXC4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXC4
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXC4
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXC4

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC4

Orthologs
for HOXC4 gene

Paralogs
for HOXC4 gene

Paralogs for HOXC4 gene

GSX1²  HOXA7²  HOXA1²  HOXD1²  HOXA2²  HOXB3²  HOXC6²  HOXB5²  

GSX2²  HOXC5²  HOXB4²  HOXA5²  HOXA4²  HOXD3²  HOXC8²  HOXA6²  

HOXA3²  HOXD8²  HOXB1²  HOXB6²  HOXB8²  HOXD4²  HOXB2²  HOXB7²  

PDX1²  

16 SIMAP similar genes for HOXC4 using alignment to 2 protein entries:     HXC4_HUMAN (see all proteins):

HOX B6    HOXD8    HOXA4    HMX2    HOXD4    HOXB4

HOXC6    HOXA7    HOXB5    HLX    HOXA5    HOXA-9

HOXB7    HOXB6    POU6F1    HOXA6

HOXC4 for paralogs           About GeneDecksing

Genomic Variants
for HOXC4 gene

10/580 NCBI SNPs in HOXC4 are shown (see all 580)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs38091571,2	C,F,H,	--	51447223(-)	CCGGCA/GTCTCT	3	--	us2k1		2		NS EA	292
rs1817292781,2	C,	--	51447351(+)	AGGCTA/GCTCGA	3	--	us2k1		0	--	--	--	--
rs128310111,2	C	--	51447564(+)	TTAATC/TTTATT	3	--	us2k1		0	--	--	--	--
rs745688901,2	F,	--	51448686(+)	AATGCA/GGGAGC	3	--	ut51 nc-transcript-variant		1		WA	118
rs1999874351,2	C	--	51449000(+)	TCCGTA/GGCGGT	3	--	int1		0	--	--	--	--
rs102194501,2	C	--	51449010(+)	TTTCAA/CGAATA	3	--	int1		0	--	--	--	--
rs1119163651,2	C,	--	51449789(+)	GCGCCC/TCTCAC	3	--	int1		0	--	--	--	--
rs1157899571,2	C,F,	--	51450322(+)	CCAGAC/TGAGGT	3	--	int1		1		WA	118
rs733131881,2	C,	--	51450975(+)	GGACAC/AAAGAG	3	--	int1		1		WA	2
rs752405841,2		--	51450986(+)	GGGCCC/TGAGAG	3	--	int1		1		WA	118

HapMap Linkage Disequilibrium report for HOXC4 (54410642 - 54449814 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HOXC4
     1 CNV: 3890

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXC4

DNA2.0 Custom Variant and Variant Library Synthesis for HOXC4

Disorders / Diseases
for HOXC4 gene

12 diseases for HOXC4

3 Novoseek disease relationships for HOXC4 gene    About this table

Publications
for HOXC4 gene

PubMed articles for HOXC4 gene, integrated from 9 sources (see all 29): (articles sorted by number of sources associating them with HOXC4)

Utopia: connect your pdf to the dynamic world of online information

1. Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. (PubMed id 16215934)^{1, 4, 9} Gong L.G....Sun K.L. (2005)
2. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)^{1, 2} Kosaki K.... Matsuo N. (2002)
3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)^{1, 3} Scott M.P. (1992)
4. Nomenclature for human homeobox genes. (PubMed id 1973146)^{1, 3} McAlpine P.J. and Shows T.B. (1990)
5. Organization of human class I homeobox genes. (PubMed id 2576652)^{1, 2} Boncinelli E.... Simeone A. (1989)
6. At least three human homeoboxes on chromosome 12 belong to the same transcription unit. (PubMed id 2898768)^{1, 2} Simeone A.... Boncinelli E. (1988)
7. [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells] (PubMed id 19236766)^{1, 9} Feng J.Q....Chen S.Q. (2009)
8. HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas. (PubMed id 9327740)^{1, 9} Bijl J.J....Meijer C.J. (1997)
9. Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. (PubMed id 12672812)^{1, 9} Schaffer A....Casali P. (2003)
10. Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes. (PubMed id 7718879)^{1, 9} Meazza R....Corte G. (1995)

External Searches for HOXC4 gene

Genome Databases showing HOXC4 gene

Other Databases showing HOXC4 gene

Specialized Databases showing HOXC4 gene

Products
for HOXC4 gene