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HOXC4 Gene

protein-coding   GIFtS: 53
GCID: GC12P054410

Homeobox C4

(Previous name: homeo box C4)
(Previous symbols: HOX3, HOX3E)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox C41 2     Homeobox Protein Hox-3E2 3
HOX3E1 2 3 5     cp192
HOX31 2     Homeo Box 3E2
Homeo Box C41 2     Homeobox Protein Hox-C42
Homeobox Protein CP192 3     

External Ids:    HGNC: 51261   Entrez Gene: 32212   Ensembl: ENSG000001983537   OMIM: 1429745   UniProtKB: P090173   

Export aliases for HOXC4 gene to outside databases

Previous GC identifers: GC12M054370 GC12P054523 GC12P054127 GC12P052696 GC12P051448


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXC4 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC
genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon.
Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the
gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for
HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific
exons. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXC4 Gene:
HOXC4 (homeobox C4) is a protein-coding gene. Diseases associated with HOXC4 include vacterl association, and esophageal atresia. GO annotations related to this gene include HMG box domain binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot: HXC4_HUMAN, P09017
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXC4 gene promoter:
         Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXC4 promoter sequence
   Search Chromatin IP Primers for HOXC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054410:  view genomic region     (about GC identifiers)

Start:
54,410,642 bp from pter      End:
54,449,814 bp from pter
Size:
39,173 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HXC4_HUMAN, P09017 (See protein sequence)
Recommended Name: Homeobox protein Hox-C4  
Size: 264 amino acids; 29811 Da

Explore the universe of human proteins at neXtProt for HOXC4: NX_P09017

Explore proteomics data for HOXC4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055435.2  NP_705897.1  

    ENSEMBL proteins: 
     ENSP00000305973   ENSP00000477362  

    HOXC4 Human Recombinant Protein Products:

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    Novus Biologicals HOXC4 Lysates
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    Cloud-Clone Corp. Proteins for HOXC4

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    Abcam antibodies for HOXC4
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    LSBio Antibodies in human, mouse, rat for HOXC4

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    Cloud-Clone Corp. CLIAs for HOXC4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry P09017

    ProtoNet protein and cluster: P09017

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXC4_HUMAN, P09017
    Similarity: Belongs to the Antp homeobox family. Deformed subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXC4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXC4_HUMAN, P09017
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXC4:
    homeo box C4(3E),Drosophila Dfd,expressed in first trimester trophoblast,involved in mouse anterior limb
    patterning,expressed in anterior limb

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0071837HMG box domain binding ----
         
    HOXC4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXC4:
     Decreased viability with pacli 

         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hoxc4):
     behavior/neurological  digestive/alimentary  hematopoietic system  immune system  mortality/aging 
     muscle  nervous system  skeleton 

    HOXC4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXC4: Hoxc4tm2.1Mrc Hoxc4tm1Hsu Hoxc4tm1Mrc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXC4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXC4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXC4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXC4

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXC4:
    hsa-mir-26b-5p (MIRT029035), hsa-mir-124-3p (MIRT022277), hsa-mir-125a-5p (MIRT021293), hsa-let-7a-5p (MIRT052528), hsa-mir-331-3p (MIRT019246), hsa-mir-615-3p (MIRT040437)

    Block miRNA regulation of human, mouse, rat HOXC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC4 (see all 34):
    hsa-miR-25 hsa-miR-765 hsa-miR-632 hsa-miR-29b-1* hsa-miR-23a hsa-miR-92b hsa-miR-4273 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidHOXC4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXC4
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HOXC4

    Clone
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    OriGene clones in human, mouse for HOXC4 (see all 10)
    OriGene ORF clones in mouse, rat for HOXC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HOXC4 (NM_014620)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HOXC4
    Browse ESI BIO Cell Lines and PureStem Progenitors for HOXC4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXC4_HUMAN, P09017: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    HOXC4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXC4: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HOXC4 (P090171, 3 ENSP000003059734) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC6P129563, ENSP000003522574I2D: score=3 STRING: ENSP00000352257
    PRKDCP785273, ENSP000003134204I2D: score=2 STRING: ENSP00000313420
    POU2F1P148593, ENSP000002714114I2D: score=1 STRING: ENSP00000271411
    SALL4Q9UJQ43, ENSP000002170864I2D: score=1 STRING: ENSP00000217086
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development IEA--
    GO:0009952anterior/posterior pattern specification ----
    GO:0048562embryonic organ morphogenesis ----

    HOXC4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXC4 (HXC4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOXC4 gene (2 alternative transcripts): 
    NM_014620.5  NM_153633.2  

    Unigene Cluster for HOXC4:

    Homeobox C4
    Hs.549040  [show with all ESTs]
    Unigene Representative Sequence: NM_014620
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303406 ENST00000507650 ENST00000609810
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXC4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXC4 (see all 34):
    hsa-miR-25 hsa-miR-765 hsa-miR-632 hsa-miR-29b-1* hsa-miR-23a hsa-miR-92b hsa-miR-4273 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidHOXC4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXC4
    Predesigned siRNA for gene silencing in human, mouse, rat HOXC4
    Clone
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    OriGene ORF clones in mouse, rat for HOXC4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HOXC4 (NM_014620)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXC4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC4
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HOXC4
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC4
      QuantiTect SYBR Green Assays in human, mouse, rat HOXC4
      QuantiFast Probe-based Assays in human, mouse, rat HOXC4

    Additional mRNA sequence: 

    AK314829.1 BC034922.1 BC044635.1 BC050442.1 BC074844.2 BC074845.2 CR456954.1 M16938.1 
    NR_003084.1 S82986.1 X07495.1 

    9 DOTS entries:

    DT.92419797  DT.97815454  DT.121149258  DT.207919  DT.92070349  DT.310047  DT.425996  DT.95265426 
    DT.95265424 

    Selected AceView cDNA sequences (see all 228):

    AI380602 NM_018953 AI159844 NM_014620 AW469953 AA827833 BF197458 BQ949038 
    BE396026 BU501253 BC074845 BM127627 BE464190 AI174335 BF057562 NM_017409 
    BM825403 AA888101 AI200419 CR600861 AW000987 BQ962391 CR622939 AA158947 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HOXC4 Expression
    About this image


    HOXC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neurons
             Anterior Latissimus Dorsi Muscle Motor Neurons Caudal Brachial Lateral Motor Division
     
     Spinal Cord (Nervous System)    fully expand to see all 5 entries
             Anterior Latissimus Dorsi Muscle Motor Neurons Caudal Brachial Lateral Motor Division
     
     Adipose (Muscoskeletal System)    fully expand to see all 4 entries
             Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             S-shaped Body
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
    HOXC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.549040
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXC4: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HOXC4
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXC4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXC4
    QuantiTect SYBR Green Assays in human, mouse, rat HOXC4
    QuantiFast Probe-based Assays in human, mouse, rat HOXC4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOXC4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxc41 , 5 homeobox C41, 5 97.35(n)1
    98.86(a)1
      15 (58.08 cM)5
    154231  NM_013553.21  NP_038581.21 
     1030189365 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    76(a)
    1 → many
    2(71987091-71988948)
    African clawed frog
    (Xenopus laevis)
    Amphibia hoxc6-A-prov2 homeo box protein 85.14(n)    X12500.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxc4a2 homeo box C4a 82.56(n)   30345  NM_131122.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dfd3 induction of apoptosis transcription
    factor
    81(a)
    (best of 2)
      3 84A5   --


    ENSEMBL Gene Tree for HOXC4 (if available)
    TreeFam Gene Tree for HOXC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXC4 gene
    HOXA72  HOXB52  HOXC62  HOXC52  HOXB42  HOXA52  ENSG000002732662  HOXA42  
    HOXC82  HOXA62  ENSG000002730492  HOXD82  HOXB62  HOXB82  HOXD42  HOXB72  
    16 SIMAP similar genes for HOXC4 using alignment to 2 protein entries:     HXC4_HUMAN (see all proteins):
    HOX B6    HOXD8    HOXA4    HMX2    HOXD4    HOXB4
    HOXC6    HOXA7    HOXB5    HLX    HOXA5    HOXA-9
    HOXB7    HOXB6    POU6F1    HOXA6

    HOXC4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXC4 (see all 391)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs714448301,2
    C--51481290(+) CACAT-/AC    
       
    /ACAC
    ACACA
    1 -- int11NA 2
    rs679541561,2
    C--51487180(+) TCCTT-/CCCCCC 2 -- ut312Minor allele frequency- C:0.25NA CSA 4
    rs1436430161,2
    C--54263367(+) GTGTTA/GGGAGA 1 -- int10--------
    rs1816699861,2
    --54263457(+) GGCAGA/GAAATG 1 -- int10--------
    rs1844054661,2
    C--54263567(+) CATCAC/TTTATC 1 -- int10--------
    rs572801901,2
    C,F--54263674(+) TCCAGG/CCTCCT 1 -- int12Minor allele frequency- C:0.12WA 120
    rs1167255141,2
    C,F--54263679(+) GCTCCT/CGGGAT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs3706262931,2
    C--54263821(+) GGGGTA/GAGGGT 1 -- int10--------
    rs340922311,2
    C--54264171(+) CAGTGCT/-CTCTC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs1409971731,2
    --54264258(+) ATTGAG/TTGAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for HOXC4 (54410642 - 54449814 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HOXC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672088CNV Deletion23128226
    nsv716CNV Insertion18451855
    nsv899102CNV Loss21882294
    nsv832418CNV Loss17160897
    nsv899100CNV Loss21882294
    nsv826379CNV Gain20364138
    nsv428282CNV Gain18775914
    dgv512e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXC4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142974    OMIM disorders: --

    13 diseases for HOXC4:    
    About MalaCards
    vacterl association    esophageal atresia    cytomegalovirus infection    anaplastic large cell lymphoma
    hodgkin's lymphoma    non-hodgkin lymphoma    lymphoblastic leukemia    b-cell lymphomas
    esophagitis    leukemia    myeloid leukemia    cervicitis
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HOXC4:
    VACTERL association

    HOXC4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for HOXC4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma non-hodgkins 46.6 2 9354682 (2)
    leukemia 33.7 3 8634419 (1), 9823947 (1), 9354682 (1)
    lymphoma 22.7 2 9327740 (2)

    Genetic Association Database (GAD): HOXC4
    Human Genome Epidemiology (HuGE) Navigator: HOXC4 (1 document)

    Export disorders for HOXC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXC4 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with HOXC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. (PubMed id 16215934)1, 4, 9 Gong L.G....Sun K.L. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    2. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (Teratology 2002)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    5. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
    6. At least three human homeoboxes on chromosome 12 belong to the same transcription unit. (PubMed id 2898768)1, 2 Simeone A.... Boncinelli E. (Nucleic Acids Res. 1988)
    7. [Effect of human cytomegalovirus infection on the expression of hoxc4 and hoxc6 genes in the proliferation of lymphocytic progenitor cells]. (PubMed id 19236766)1, 9 Feng J.Q....Chen S.Q. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    8. HOXC4, HOXC5, and HOXC6 expression in primary cutaneous lymphoid lesions. High expression of HOXC5 in anaplastic large-cell lymphomas. (PubMed id 9327740)1, 9 Bijl J.J....Meijer C.J. (Am. J. Pathol. 1997)
    9. Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements. (PubMed id 12672812)1, 9 Schaffer A....Casali P. (J. Biol. Chem. 2003)
    10. Expression of HOXC4 homeoprotein in the nucleus of activated human lymphocytes. (PubMed id 7718879)1, 9 Meazza R....Corte G. (Blood 1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3221 HGNC: 5126 AceView: HOXC6 Ensembl:ENSG00000198353 euGenes: HUgn3221
    ECgene: HOXC4 H-InvDB: HOXC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXC4 gene:
    Search GeneIP for patents involving HOXC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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