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Aliases for HOXC13 Gene

Aliases for HOXC13 Gene

  • Homeobox C13 2 3
  • HOX3G 3 4 6
  • Homeobox Protein Hox-3G 3 4
  • ECTD9 3 6
  • Homeobox Protein Hox-C13 3
  • Homeo Box C13 2
  • Homeo Box 3G 3
  • NUP98/HOXC13 3
  • HOX3 3

External Ids for HOXC13 Gene

Previous HGNC Symbols for HOXC13 Gene

  • HOX3
  • HOX3G

Previous GeneCards Identifiers for HOXC13 Gene

  • GC12M054479
  • GC12P054444
  • GC12P054049
  • GC12P052618
  • GC12P054332
  • GC12P051370

Summaries for HOXC13 Gene

Entrez Gene Summary for HOXC13 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC13 Gene

HOXC13 (Homeobox C13) is a Protein Coding gene. Diseases associated with HOXC13 include ectodermal dysplasia 9, hair/nail type and ectodermal dysplasia 4, hair/nail type. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXC13 Gene

  • Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity).

Gene Wiki entry for HOXC13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC13 Gene

Genomics for HOXC13 Gene

Regulatory Elements for HOXC13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXC13 Gene

Start:
53,938,765 bp from pter
End:
53,946,544 bp from pter
Size:
7,780 bases
Orientation:
Plus strand

Genomic View for HOXC13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXC13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC13 Gene

Proteins for HOXC13 Gene

  • Protein details for HOXC13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31276-HXC13_HUMAN
    Recommended name:
    Homeobox protein Hox-C13
    Protein Accession:
    P31276
    Secondary Accessions:
    • Q5BL02
    • Q96J32
    • Q9NR24
    • Q9NYD5

    Protein attributes for HOXC13 Gene

    Size:
    330 amino acids
    Molecular mass:
    35379 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC13 Gene

Proteomics data for HOXC13 Gene at MOPED

Post-translational modifications for HOXC13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC13 Gene

Domains for HOXC13 Gene

Gene Families for HOXC13 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for HOXC13 Gene

Suggested Antigen Peptide Sequences for HOXC13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31276

UniProtKB/Swiss-Prot:

HXC13_HUMAN :
  • P31276
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXC13: view

Function for HOXC13 Gene

Molecular function for HOXC13 Gene

GENATLAS Biochemistry: homeo box C13(3G)
UniProtKB/Swiss-Prot Function: Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity).

Gene Ontology (GO) - Molecular Function for HOXC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 18692240
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC13: view
genes like me logo Genes that share phenotypes with HOXC13: view

Animal Models for HOXC13 Gene

MGI Knock Outs for HOXC13:

Animal Model Products

CRISPR Products

miRNA for HOXC13 Gene

miRTarBase miRNAs that target HOXC13

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXC13 Gene

Localization for HOXC13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC13 Gene COMPARTMENTS Subcellular localization image for HOXC13 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for HOXC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXC13: view

Pathways for HOXC13 Gene

SuperPathways for HOXC13 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HOXC13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001942 hair follicle development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0009653 anatomical structure morphogenesis TAS 10835276
GO:0009952 anterior/posterior pattern specification IEA --
GO:0035878 nail development IEA --
genes like me logo Genes that share ontologies with HOXC13: view

No data available for Pathways by source for HOXC13 Gene

Transcripts for HOXC13 Gene

mRNA/cDNA for HOXC13 Gene

(41) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXC13 Gene

Homeobox C13:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC13 Gene

No ASD Table

Relevant External Links for HOXC13 Gene

GeneLoc Exon Structure for
HOXC13
ECgene alternative splicing isoforms for
HOXC13

Expression for HOXC13 Gene

mRNA expression in normal human tissues for HOXC13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC13 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (25.7) and Skin - Sun Exposed (Lower leg) (17.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXC13 Gene

SOURCE GeneReport for Unigene cluster for HOXC13 Gene Hs.118608

genes like me logo Genes that share expressions with HOXC13: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXC13 Gene

Orthologs for HOXC13 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXC13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXC13 35
  • 99.7 (n)
  • 100 (a)
HOXC13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXC13 35
  • 93.84 (n)
  • 97.58 (a)
HOXC13 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXC13 35
  • 95.06 (n)
  • 98.46 (a)
HOXC13 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxc13 35
  • 91.97 (n)
  • 96.95 (a)
Hoxc13 16
Hoxc13 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC13 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxc13 35
  • 93.19 (n)
  • 96.65 (a)
lizard
(Anolis carolinensis)
Reptilia HOXC13 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13513 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487255 35
  • 71.71 (n)
  • 75.66 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.15286 35
hoxc13a 35
  • 70.86 (n)
  • 75.87 (a)
hoxc13a 36
  • 77 (a)
OneToMany
hoxc13b 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Abd-B 36
  • 15 (a)
OneToMany
Species with no ortholog for HOXC13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC13 Gene

ENSEMBL:
Gene Tree for HOXC13 (if available)
TreeFam:
Gene Tree for HOXC13 (if available)

Paralogs for HOXC13 Gene

genes like me logo Genes that share paralogs with HOXC13: view

Variants for HOXC13 Gene

Sequence variations from dbSNP and Humsavar for HOXC13 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11942 -- 53,946,301(+) GTAGA(C/T)GCTGC utr-variant-3-prime
rs733412 -- 53,944,936(-) GACCC(C/G)AGGCT intron-variant
rs1054251 -- 53,946,504(+) AACCC(A/C)CAAAC utr-variant-3-prime
rs1373160 -- 53,946,599(+) AGGAC(A/G)GTCTA downstream-variant-500B
rs1443509 -- 53,946,838(+) ATGGT(C/T)ACTTC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HOXC13 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138

Relevant External Links for HOXC13 Gene

HapMap Linkage Disequilibrium report
HOXC13
Human Gene Mutation Database (HGMD)
HOXC13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC13 Gene

Disorders for HOXC13 Gene

(1) OMIM Diseases for HOXC13 Gene (142976)

UniProtKB/Swiss-Prot

HXC13_HUMAN
  • Ectodermal dysplasia 9, hair/nail type (ECTD9) [MIM:614931]: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair, teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical features represents a different type of ectodermal dysplasia. ECTD9 is characterized by hypotrichosis and nail dystrophy without non-ectodermal or other ectodermal manifestations. Hypotrichosis usually occurs after birth with varying degrees of severity, ranging from mild hair loss to complete atrichia, including the loss of scalp hair, beard, eyebrows, eyelashes, axillary hair, and pubic hair. Nail dystrophy affects all 20 digits by causing short fragile nails or spoon nails (koilonychia). {ECO:0000269 PubMed:23063621}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for HOXC13 Gene

Relevant External Links for HOXC13

Genetic Association Database (GAD)
HOXC13
Human Genome Epidemiology (HuGE) Navigator
HOXC13
genes like me logo Genes that share disorders with HOXC13: view

Publications for HOXC13 Gene

  1. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  2. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  3. The human HOX gene family. (PMID: 2574852) Acampora D. … Boncinelli E. (Nucleic Acids Res. 1989) 3 4
  4. Selection of homeotic proteins for binding to a human DNA replication origin. (PMID: 10835276) de Stanchina E. … Biamonti G. (J. Mol. Biol. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for HOXC13 Gene

Sources for HOXC13 Gene

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