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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXC13 Gene

protein-coding   GIFtS: 57
GCID: GC12P054332

Homeobox C13

(Previous name: homeo box C13)
(Previous symbols: HOX3, HOX3G)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homeobox C131 2     ECTD92
HOX3G1 2 3 5     NUP98/HOXC132
HOX31 2     Homeo Box 3G2
Homeobox Protein Hox-3G2 3     Homeobox Protein Hox-C132
Homeo Box C131     

External Ids:    HGNC: 51251   Entrez Gene: 32292   Ensembl: ENSG000001233647   OMIM: 1429765   UniProtKB: P312763   

Export aliases for HOXC13 gene to outside databases

Previous GC identifers: GC12M054479 GC12P054444 GC12P054049 GC12P052618 GC12P051370


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXC13 Gene:
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of
transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals
possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different
chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes
located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail,
and filiform papilla. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXC13 Gene: 
HOXC13 (homeobox C13) is a protein-coding gene. Diseases associated with HOXC13 include skin pilomatrix carcinoma, and pilomatrixoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA9.

UniProtKB/Swiss-Prot: HXC13_HUMAN, P31276
Function: Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and
that of other hair-specific genes (By similarity)

Gene Wiki entry for HOXC13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXC13 gene promoter:
         Sox5   NRSF form 1   Nkx2-5   NRSF form 2   CREB   AREB6   PPAR-gamma1   deltaCREB   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXC13 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXC13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXC13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

HOXC13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXC13 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P054332:  view genomic region     (about GC identifiers)

Start:
54,332,535 bp from pter      End:
54,340,328 bp from pter
Size:
7,794 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXC13_HUMAN, P31276 (See protein sequence)
Recommended Name: Homeobox protein Hox-C13  
Size: 330 amino acids; 35379 Da
Subcellular location: Nucleus
Secondary accessions: Q5BL02 Q96J32 Q9NR24 Q9NYD5

Explore the universe of human proteins at neXtProt for HOXC13: NX_P31276

Explore proteomics data for HOXC13 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31276

  • HOXC13 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXC13 Protein Expression
    REFSEQ proteins: NP_059106.2  
    ENSEMBL proteins: 
     ENSP00000243056  

    Human Recombinant Protein Products for HOXC13: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXC13 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    HOXC13 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    4 InterPro protein domains:
     IPR022067 HoxA13_N
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P31276

    ProtoNet protein and cluster: P31276

    UniProtKB/Swiss-Prot: HXC13_HUMAN, P31276
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXC13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXC13_HUMAN, P31276
    Function: Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and
    that of other hair-specific genes (By similarity)

         Genatlas biochemistry entry for HOXC13:
    homeo box C13(3G)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding ----
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0005515protein binding IPI18692240
         
    HOXC13 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for HOXC13:
     Decreased viability  Decreased viability with pacli 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hoxc13):
     behavior/neurological  craniofacial  digestive/alimentary  growth/size  integument 
     limbs/digits/tail  mortality/aging  skeleton  vision/eye 

    HOXC13 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hoxc13tm1Mrc for HOXC13

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXC13 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXC13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXC13 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXC13 

    miRNA
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    miRTarBase miRNAs that target HOXC13:
    hsa-mir-31 (MIRT004974)

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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC13 (see all 55):
    hsa-miR-194* hsa-miR-2052 hsa-miR-607 hsa-miR-19b-2* hsa-miR-15a hsa-miR-200a hsa-miR-29a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidHOXC13 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC13


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXC13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    8/9 Interacting proteins for HOXC13 (P312761, 3 ENSP000002430564) via UniProtKB, MINT, STRING, and/or I2D (see all 9) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELF1P325191, 3, ENSP000002398824EBI-2293590,EBI-765526 I2D: score=2 STRING: ENSP00000239882
    MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
    APEX1P276953, ENSP000002167144I2D: score=1 STRING: ENSP00000216714
    RHOXF2Q9BQY43, ENSP000003604414I2D: score=1 STRING: ENSP00000360441
    HNRNPABQ997293, ENSP000003511084I2D: score=1 STRING: ENSP00000351108
    HOXC9P312743, ENSP000003028364I2D: score=1 STRING: ENSP00000302836
    NR2E3Q9Y5X43I2D: score=1 
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0006351transcription, DNA-dependent ----
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development NAS--
    GO:0009653anatomical structure morphogenesis TAS10835276

    HOXC13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXC13 (HXC13)

    Search CenterWatch for drugs/clinical trials and news about HOXC13 / HXC13

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXC13 gene: 
    NM_017410.2  

    Unigene Cluster for HOXC13:

    Homeobox C13
    Hs.118608  [show with all ESTs]
    Unigene Representative Sequence: NM_017410
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000243056(uc001sei.3)
    miRNA
    Products:
         
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    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXC13 (see all 55):
    hsa-miR-194* hsa-miR-2052 hsa-miR-607 hsa-miR-19b-2* hsa-miR-15a hsa-miR-200a hsa-miR-29a hsa-miR-507
    SwitchGear 3'UTR luciferase reporter plasmidHOXC13 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXC13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXC13
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXC13
    Sirion Biotech Customized lentivirus for stable overexpression of HOXC13 
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    OriGene qPCR primer pairs and template standards for HOXC13
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXC13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXC13

    Additional mRNA sequence: 

    AF255676.1 AF263466.2 AK024027.1 BC090850.1 BT009908.1 X99679.1 

    2 DOTS entries:

    DT.440767  DT.95363866 

    24/41 AceView cDNA sequences (see all 41):

    BM795968 BQ937704 CR611726 NM_017410 X99679 AL578192 AF263466 BF752820 
    BC002754 AF255676 AK024027 BX094352 AA722686 BU158600 AU143101 BX350407 
    BV178477 AI583687 BT009908 BQ423804 AI223853 BX389986 AI811286 BE150664 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXC13 expression in normal human tissues (normalized intensities)      HOXC13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTAAAAT
    HOXC13 Expression
    About this image


    HOXC13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Hair (Integumentary System)    fully expand to see all 6 entries
             Fetal Medulla Cells Hair Shaft
     
     Uterus (Reproductive System)
             CERVIX   
     
     Uncategorized (Uncategorized)
             PureStem progenitor W8
     
     Heart (Cardiovascular System)

    See HOXC13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXC13

    SOURCE GeneReport for Unigene cluster: Hs.118608
        SABiosciences Expression via Pathway-Focused PCR Array including HOXC13: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for HOXC13 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxc131 , 5 homeobox C131, 5 93.5(n)1
    98.78(a)1
      15 (57.99 cM)5
    154221  NM_010464.21  NP_034594.11 
     1029211035 
    lizard
    (Anolis carolinensis)
    Reptilia HOXC136
    Uncharacterized protein
    80(a)
    1 ↔ 1
    2(72155534-72161803)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135132 Xenopus laevis transcribed sequence with moderate similarity more 75.86(n)    BJ037972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.152862 Transcribed sequence with moderate similarity to protein more 75.42(n)    BM186986.1 


    ENSEMBL Gene Tree for HOXC13 (if available)
    TreeFam Gene Tree for HOXC13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXC13 gene
    HOXA92  HOXA132  HOXC92  HOXD112  HOXC122  HOXB132  ENSG000002571842  HOXC112  
    HOXD102  HOXA112  HOXD132  HOXB92  HOXC102  HOXD92  HOXD122  HOXA102  
    18/29 SIMAP similar genes for HOXC13 using alignment to 2 protein entries:     HXC13_HUMAN (see all proteins) (see all similar genes):
    NUP98/HOXC13    CDX1    CDX2    HOXD12    HOXA10    HOXD13
    GSX2    MEOX2    HOXA4    HOXA5    HOXB7    HOXB8
    HOXC6    HOXA11    HOXB1    HOXD11    HOXB13    HOXD9

    HOXC13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/201 SNPs in HOXC13 are shown (see all 201)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs751788861,2
    C,F--54164154(+) ACCCAC/ACCACC 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs1492503681,2
    --54164239(+) CTCCTC/TGTTTT 1 -- us2k10--------
    rs788956041,2
    --54164311(+) AGACCC/GTATCT 1 -- us2k10--------
    rs1390750781,2
    --54164483(+) GATCAC/TGCAGA 1 -- us2k10--------
    rs73005101,2
    A--54164484(+) ATCACG/TCAGAT 1 -- us2k10--------
    rs23661461,2
    C,F,A,H--54164565(+) GAGGAA/GGGAGG 1 -- us2k1 tfbs3 trp313Minor allele frequency- G:0.21EA NA WA CSA 1278
    rs1859364531,2
    --54164670(+) TCTGTC/GCGCTG 1 -- us2k10--------
    rs1424960641,2
    --54164685(+) CACACA/GAGCAC 1 -- us2k10--------
    rs37591621,2
    C,F,A,H--54164717(+) AGAGGC/GAGGAA 1 -- us2k1 tfbs3 trp317Minor allele frequency- G:0.21NS EA NA WA CSA 787
    rs1908430281,2
    --54164763(+) TTTCTC/TTCTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOXC13 (54332535 - 54340328 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HOXC13:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv826379CNV Gain20364138


    Human Gene Mutation Database (HGMD): HOXC13
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142976    OMIM disorders: --

    UniProtKB/Swiss-Prot: HXC13_HUMAN, P31276
  • Ectodermal dysplasia 9, hair/nail type (ECTD9) [MIM:614931]: A form of ectodermal dysplasia, a
    heterogeneous group of disorders due to abnormal development of two or more ectodermal structures such as hair,
    teeth, nails and sweat glands, with or without any additional clinical sign. Each combination of clinical
    features represents a different type of ectodermal dysplasia. ECTD9 is characterized by hypotrichosis and nail
    dystrophy without non-ectodermal or other ectodermal manifestations. Hypotrichosis usually occurs after birth
    with varying degrees of severity, ranging from mild hair loss to complete atrichia, including the loss of scalp
    hair, beard, eyebrows, eyelashes, axillary hair, and pubic hair. Nail dystrophy affects all 20 digits by causing
    short fragile nails or spoon nails (koilonychia). Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 10 diseases for HOXC13:    About MalaCards
    skin pilomatrix carcinoma    pilomatrixoma    monilethrix    biliary atresia
    ectodermal dysplasia    acute myeloid leukemia    alopecia    myeloid leukemia
    leukemia    melanoma

    2 diseases from the University of Copenhagen DISEASES database for HOXC13:
    Skin pilomatrix carcinoma     Alopecia

    HOXC13 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HOXC13
    Human Genome Epidemiology (HuGE) Navigator: HOXC13 (1 document)

    Export disorders for HOXC13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXC13 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with HOXC13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Loss-of-function mutations in HOXC13 cause pure hair a nd nail ectodermal dysplasia. (PubMed id 23063621)1, 2 Lin Z....Yang Y. (2012)
    2. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distr ibution. (PubMed id 20935629)1, 4 Heid I.M....Lindgren C.M. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Selection of homeotic proteins for binding to a human DNA replication origin. (PubMed id 10835276)1, 2 de Stanchina E.... Biamonti G. (2000)
    6. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    8. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    9. Krtap16, characterization of a new hair keratin-associated protein (KAP) gene complex on mouse chromosome 16 and evidence for regulation by Hoxc13. (PubMed id 15385554)1, 9 Pruett N.D....Awgulewitsch A. (2004)
    10. A homozygous frameshift mutation in the HOXC13 gene un derlies pure hair and nail ectodermal dysplasia in a Syrian family. (PubMed id 23315978)1 Farooq M....Shimomura Y. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3229 HGNC: 5125 AceView: HOXC13 Ensembl:ENSG00000123364 euGenes: HUgn3229
    ECgene: HOXC13 H-InvDB: HOXC13

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXC13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HOXC13 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXC13 gene:
    Search GeneIP for patents involving HOXC13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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