Aliases for HOXC12 Gene
Subcategory (RNA class) for HOXC12 Gene
lncRNA
Aliases for HOXC12 Gene
External Ids for HOXC12 Gene
- HGNC: 5124
- Entrez Gene: 3228
- Ensembl: ENSG00000123407
- OMIM: 142975
- UniProtKB: P31275
ORGUL Members for HOXC12 Gene
Previous HGNC Symbols for HOXC12 Gene
- HOX3
- HOX3F
- HOC3F
Previous GeneCards Identifiers for HOXC12 Gene
- GC12U990037
- GC12P054461
- GC12P054065
- GC12P052634
- GC12P054349
- GC12P051386
- GC12P054354
- GC12P054358
Summaries for HOXC12 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXC12 Gene
HOXC12 (Homeobox C12) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with HOXC12 include Clubfoot. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD12.
UniProtKB/Swiss-Prot for HOXC12 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC12 Gene
Genomics for HOXC12 Gene
Regulatory Elements for HOXC12 Gene
Enhancers for HOXC12 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G053971 | 2.1 | FANTOM5 Ensembl ENCODE dbSUPER | 15.1 | +35.4 | 35409 | 36.8 | CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 | ZNF740 MAP3K12 ENSG00000258344 LOC100652999 HOXC8 HOXC5 SP1 HOTAIR CBX5 HOXC4 |
| GH12G054377 | 1.3 | ENCODE dbSUPER | 6 | +424.3 | 424347 | 2.4 | HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 ZNF207 ZNF143 DEK ZNF263 | MAP3K12 ENSG00000258086 HOXC5 MIR148B RNU6-950P COPZ1 HOXC8 ITGA5 HOXC9 HOXC12 |
| GH12G054373 | 1.3 | FANTOM5 ENCODE dbSUPER | 5.9 | +420.6 | 420589 | 4.6 | PKNOX1 KLF1 ZNF146 ZSCAN4 KLF17 ZIC2 ZFHX2 GLIS2 ZNF316 PRDM10 | MIR148B RNU6-950P COPZ1 ITGA5 ZNF385A HOXC12 HNRNPA1 GPR84 |
| GH12G054050 | 0.8 | FANTOM5 | 1.9 | +95.7 | 95672 | 0.2 | FOXA2 SUZ12 ZNF792 BMI1 BCL11B GATA3 GATA2 ZNF366 PATZ1 EZH2 | ATP5G2 HOXC11 HOXC12 ATF7 FLJ12825 GC12P054072 PIR31123 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXC12 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXC12 gene promoter:
Regulatory Element Products
Genomic Location for HOXC12 Gene
- Chromosome:
- 12
- Start:
- 53,954,834 bp from pter
- End:
- 53,958,956 bp from pter
- Size:
- 4,123 bases
- Orientation:
- Plus strand
Genomic View for HOXC12 Gene
Genes around HOXC12 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
HOXC12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXC12 Gene
Proteins for HOXC12 Gene
-
Protein details for HOXC12 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31275-HXC12_HUMAN
- Recommended name:
- Homeobox protein Hox-C12
- Protein Accession:
- P31275
- Q9BXJ6
Protein attributes for HOXC12 Gene
- Size:
- 282 amino acids
- Molecular mass:
- 30171 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXC12 Gene
Post-translational modifications for HOXC12 Gene
Other Protein References for HOXC12 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOXC12
- Novus Biologicals Antibodies for HOXC12
- Invitrogen Antibodies for HOXC12
- antibodies-online Antibodies for HOXC12: See all 37
- Search GeneTex for Antibodies for HOXC12
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXC12
Protein Products
-
OriGene Purified Proteins for HOXC12
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXC12
- Origene Custom Protein Services for HOXC12
- antibodies-online Proteins for HOXC12: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXC12
Assay Products
No data available for DME Specific Peptides for HOXC12 Gene
Domains & Families for HOXC12 Gene
Gene Families for HOXC12 Gene
Protein Domains for HOXC12 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXC12 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31275- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXC12 Gene
Molecular function for HOXC12 Gene
- GENATLAS Biochemistry:
- homeo box C12(3F)
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXC12 Gene
- MGI mutant phenotypes for HOXC12:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXC12:
Animal Models for HOXC12 Gene
- MGI Knock Outs for HOXC12:
-
- Hoxc12 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXC12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC12 gene
- Search ViGene Biosciences for HOXC12
CRISPR Products
-
OriGene CRISPR knockouts for HOXC12
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC12
- GenScript: Design CRISPR guide RNA sequences for HOXC12
miRNA for HOXC12 Gene
- miRTarBase miRNAs that target HOXC12
miRNA Products
- Search ViGene Biosciences for HOXC12
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXC12
- Browse OriGene Inhibitory RNA Products For HOXC12
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC12 gene
Clone Products
-
OriGene ORF clones in human for HOXC12
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Cell Line Products
-
Horizon Cell Lines for HOXC12
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXC12 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXC12 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC12 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC12 Gene
Localization for HOXC12 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXC12 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for HOXC12 Gene
No Data Available
Interacting Proteins for HOXC12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXC12 Gene
Transcripts for HOXC12 Gene
mRNA/cDNA for HOXC12 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (5) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HOXC12 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HOXC12
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC12
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miRNA Products
- Search ViGene Biosciences for HOXC12
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC12 gene
Clone Products
-
OriGene ORF clones in human for HOXC12
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Flow Cytometry Products
Expression for HOXC12 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Fetal Matrix Cells Hair Follicle
- Fetal Precortex Cells Hair Shaft
- Fetal Cortex Cells Hair Shaft
-
Epithelial Cells
- Fetal Matrix Cells Hair Follicle
- Fetal Precortex Cells Hair Shaft
- Fetal Cortex Cells Hair Shaft
mRNA differential expression in normal tissues according to GTEx for HOXC12 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x18.2), Artery - Tibial (x10.4), Skin - Not Sun Exposed (Suprapubic) (x9.4), and Adipose - Subcutaneous (x7.4).
This gene is overexpressed in Bone (32.2), Spleen (25.0), and Testis (11.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXC12 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXC12 Gene:
HOXC12SOURCE GeneReport for Unigene cluster for HOXC12 Gene:
Hs.381267Primer Products
-
OriGene qPCR primer pairs for HOXC12
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC12 Gene
Orthologs for HOXC12 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXC12 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXC12 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXC12 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HOXC12 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxc12 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxc12 34 16 35 |
|
||
| chicken (Gallus gallus) |
Aves | HOXC12 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXC12 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxc12 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | hoxc12-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxc12a 34 35 |
|
||
| hoxc12b 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXC12 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXC12 Gene
Paralogs for HOXC12 Gene
(1) SIMAP similar genes for HOXC12 Gene using alignment to 1 proteins:
Variants for HOXC12 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000227690 | -- | 53,952,924(+) | TCCGT(A/G)GCCTC | downstream-variant-500B, upstream-variant-2KB | |
| rs1000727625 | -- | 53,957,040(+) | GAGAG(A/G/T)AGGGT | downstream-variant-500B, upstream-variant-2KB | |
| rs1001086354 | -- | 53,956,829(+) | AGGCT(C/G)AGGTG | downstream-variant-500B, upstream-variant-2KB | |
| rs1002566040 | -- | 53,956,360(+) | GCTCT(A/C)GGAAG | nc-transcript-variant, reference, synonymous-codon | |
| rs1002785701 | -- | 53,956,117(+) | AAAGG(-/A)AAAAA | intron-variant |
Residual Variation Intolerance Score:
42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.64;
45.60% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXC12 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC12 Gene
Disorders for HOXC12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| clubfoot |
|
|
Search HOXC12 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXC12
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HOXC12
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXC12 Gene
Publications for HOXC12 Gene
- Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 64
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
- Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3 64
- The human HOX gene family. (PMID: 2574852) Acampora D. … Boncinelli E. (Nucleic Acids Res. 1989) 3 4 64
- Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus. (PMID: 26729820) Alvarado D.M. … Gurnett C.A. (J. Med. Genet. 2016) 3 64
Products for HOXC12 Gene
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- Custom Antibody ServicesOriGene Antibodies for HOXC12
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- OriGene Purified Proteins for HOXC12
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- Novus Biologicals Antibodies for HOXC12
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- antibodies-online Antibodies for HOXC12: See all 37
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- antibodies-online Proteins for HOXC12: See all 4
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXC12 gene
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- VectorBuilder custom plasmid, inducible vectors for HOXC12
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXC12 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
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- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer