Aliases for HOXC11 Gene
Aliases for HOXC11 Gene
External Ids for HOXC11 Gene
- HGNC: 5123
- Entrez Gene: 3227
- Ensembl: ENSG00000123388
- OMIM: 605559
- UniProtKB: O43248
Previous HGNC Symbols for HOXC11 Gene
- HOX3H
Previous GeneCards Identifiers for HOXC11 Gene
- GC12M054415
- GC12P054479
- GC12P054083
- GC12P052653
- GC12P054366
- GC12P051405
Summaries for HOXC11 Gene
-
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXC11 Gene
HOXC11 (Homeobox C11) is a Protein Coding gene. Diseases associated with HOXC11 include Childhood Type Dermatomyositis. Among its related pathways are Mesodermal Commitment Pathway. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is HOXA11.
UniProtKB/Swiss-Prot for HOXC11 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC11 Gene
Genomics for HOXC11 Gene
Regulatory Elements for HOXC11 Gene
Enhancers for HOXC11 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXC11 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXC11 gene promoter:
Regulatory Element Products
Genomic Location for HOXC11 Gene
- Chromosome:
- 12
- Start:
- 53,973,126 bp from pter
- End:
- 53,977,643 bp from pter
- Size:
- 4,518 bases
- Orientation:
- Plus strand
Genomic View for HOXC11 Gene
Genes around HOXC11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.13 by Ensembl
- 12q13.13 by Entrez Gene
- 12q13.13 by HGNC
HOXC11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXC11 Gene
Proteins for HOXC11 Gene
-
Protein details for HOXC11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43248-HXC11_HUMAN
- Recommended name:
- Homeobox protein Hox-C11
- Protein Accession:
- O43248
- A8K7D1
- Q96DH2
Protein attributes for HOXC11 Gene
- Size:
- 304 amino acids
- Molecular mass:
- 33748 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HOXC11 Gene
Other Protein References for HOXC11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXC11
-
Abcam antibodies for HOXC11
- Invitrogen Antibodies for HOXC11
- antibodies-online Antibodies for HOXC11: See all 61
- GeneTex HOXC11 antibody for HOXC11
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXC11
Protein Products
-
OriGene Purified Proteins for HOXC11
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXC11
- Origene Custom Protein Services for HOXC11
- ProSpec Recombinant Proteins for HOXC11
- antibodies-online Proteins for HOXC11: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXC11
-
Abcam proteins for HOXC11
Assay Products
No data available for DME Specific Peptides for HOXC11 Gene
Domains & Families for HOXC11 Gene
Gene Families for HOXC11 Gene
Protein Domains for HOXC11 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXC11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43248- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXC11 Gene
Molecular function for HOXC11 Gene
- GENATLAS Biochemistry:
- homeo box C11(3H),homologous to mouse Hox-3.7,involved in mouse posterior limb patterning expressed in posterior limb
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 9582375 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IDA | 9582375 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXC11 Gene
- MGI mutant phenotypes for HOXC11:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXC11:
Animal Models for HOXC11 Gene
- MGI Knock Outs for HOXC11:
-
- Hoxc11 tm1Mrc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXC11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC11 gene
- Search ViGene Biosciences for HOXC11
CRISPR Products
-
OriGene CRISPR knockouts for HOXC11
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC11
- GenScript: Design CRISPR guide RNA sequences for HOXC11
miRNA for HOXC11 Gene
- miRTarBase miRNAs that target HOXC11
-
- hsa-mir-320b (MIRT036198)
- hsa-mir-744-5p (MIRT037653)
- hsa-mir-484 (MIRT042340)
- hsa-mir-106a-5p (MIRT048337)
- hsa-mir-466 (MIRT513860)
- hsa-mir-3683 (MIRT513861)
- hsa-mir-1273c (MIRT513862)
- hsa-mir-4643 (MIRT513863)
- hsa-mir-4789-3p (MIRT513864)
- hsa-mir-3150b-5p (MIRT513865)
- hsa-mir-3150a-5p (MIRT513866)
miRNA Products
- Search ViGene Biosciences for HOXC11
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXC11
- Browse OriGene Inhibitory RNA Products For HOXC11
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC11 gene
Clone Products
-
OriGene ORF clones in human for HOXC11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HOXC11
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXC11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXC11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC11 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC11 Gene
Localization for HOXC11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXC11 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HOXC11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mesodermal Commitment Pathway | ||
Pathways by source for HOXC11 Gene
1 BioSystems pathway for HOXC11 Gene
Interacting Proteins for HOXC11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0001656 | metanephros development | IEA | -- |
| GO:0001759 | organ induction | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Transcripts for HOXC11 Gene
mRNA/cDNA for HOXC11 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (20) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXC11
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXC11
- GenScript: Design CRISPR guide RNA sequences for HOXC11
miRNA Products
- Search ViGene Biosciences for HOXC11
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXC11
- Browse OriGene Inhibitory RNA Products For HOXC11
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXC11 gene
Clone Products
-
OriGene ORF clones in human for HOXC11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HOXC11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
- Prechondrocytic Mesenchymal Cells Vertebral Body
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
- Prechondrocytic Mesenchymal Cells Vertebral Body
-
Limb (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
- Limb Bud Mesenchyme Cells Limb Bud
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Skeletal Muscle (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for HOXC11 Gene
This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.8), Artery - Tibial (x9.1), and Skin - Not Sun Exposed (Suprapubic) (x6.1).
NURSA nuclear receptor signaling pathways regulating expression of HOXC11 Gene:
HOXC11SOURCE GeneReport for Unigene cluster for HOXC11 Gene:
Hs.127562Primer Products
-
OriGene qPCR primer pairs for HOXC11
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXC11 Gene
Orthologs for HOXC11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXC11 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXC11 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100911859 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXC11 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxc11 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXC11 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXC11 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXC11 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100487406 34 |
|
||
| Str.11603 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | hoxc11a 34 35 |
|
||
| hoxc11b 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXC11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXC11 Gene
Paralogs for HOXC11 Gene
(2) SIMAP similar genes for HOXC11 Gene using alignment to 2 proteins:
Variants for HOXC11 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs12427129 | -- | ||||
| rs34652380 | -- |
Residual Variation Intolerance Score:
64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.40;
71.16% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXC11 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC11 Gene
Disorders for HOXC11 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| childhood type dermatomyositis |
|
|
Search HOXC11 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXC11
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HOXC11
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXC11 Gene
Publications for HOXC11 Gene
- The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription. (PMID: 9582375) Mitchelmore C.E. … Noren O. (J. Biol. Chem. 1998) 3 4 22 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 64
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
- Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3 64
Products for HOXC11 Gene
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- Custom Antibody ServicesOriGene Antibodies for HOXC11
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- OriGene Purified Proteins for HOXC11
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- OriGene qPCR primer pairs for HOXC11
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- GenScript: Design CRISPR guide RNA sequences for HOXC11
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- Novus Biologicals Antibodies for HOXC11
- Novus Biologicals proteins and lysates for HOXC11
- Novus Biologicals
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- Abcam antibodies for HOXC11
- Abcam proteins for HOXC11
- Search for Assays for HOXC11 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- ProSpec Recombinant Proteins for HOXC11
- antibodies-online Antibodies for HOXC11: See all 61
- Search antibodies-online for kits
- antibodies-online Proteins for HOXC11: See all 4
- Search antibodies-online for peptides
- GeneTex HOXC11 antibody for HOXC11
- Search GeneTex for Proteins for HOXC11
- ViGene Biosciences adenoviral particle packaged cDNA for HOXC11 gene
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- Search ViGene Biosciences for HOXC11
- Santa Cruz Biotechnology (SCBT) Antibodies for HOXC11
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- Horizon Cell Lines for HOXC11
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- VectorBuilder custom plasmid, inducible vectors for HOXC11
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXC11
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXC11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer