HOXC10 Gene
protein-coding GIFtS : 49
GCID: GC12 P054378
homeobox C10 (Previous name: homeo box C10 ) (Previous symbol: HOX3I )
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Aliasesfor HOXC10 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Homeobox C10 1 2 HOX3I1 2 3 Homeo Box C101 2 Homeobox Protein Hox-3I2 3 Homeobox Protein Hox-C102 Homeoprotein C102
Export aliases for HOXC10 gene to outside databases Previous GC identifers: GC12M054414 GC12P054491 GC12P054095 GC12P052665 GC12P051416
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Summariesfor HOXC10 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for HOXC10 : This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: HXC10_HUMAN, Q9NYD6 Function : Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis Gene Wiki entry for HOXC10
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Genomic Viewsfor HOXC10 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the HOXC10 gene promoter: E2F-4 E2F-3a E2F E2F-1 FOXO1a E2F-2 Other transcription factors Search SABiosciences Chromatin IP Primers for HOXC10 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat HOXC10
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q13.13 HOXC10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P054378: view genomic region
(about GC identifiers )
Start:
54,378,849 bp from pter
End:
54,384,063 bp from pter
Size:
5,215 bases
Orientation:
plus strand
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Proteinsfor HOXC10 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: HXC10_HUMAN, Q9NYD6 (See
protein sequence )Recommended Name: Homeobox protein Hox-C10 Size : 342 amino acids; 38073 Da
Subcellular location : Nucleus
Secondary accessions : O15219 O15220 Q9BVD5Explore the universe of human proteins at neXtProt for HOXC10: NX_Q9NYD6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9NYD6 HOXC10 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_059105.2 ENSEMBL proteins: ENSP00000421946 ENSP00000307321 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0019907 colocalizes with cyclin-dependent protein kinase activating kinase holoenzyme complex
IDA 11445587
HOXC10 for ontologies About GeneDecksing HOXC10 Antibody Products: Assay Products for HOXC10:
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Protein
Domains / Familiesfor HOXC10 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
HOXC10 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9NYD6 ProtoNet protein and cluster: Q9NYD6
UniProtKB/Swiss-Prot: HXC10_HUMAN, Q9NYD6 Similarity : Belongs to the Abd-B homeobox familySimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor HOXC10 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: HXC10_HUMAN, Q9NYD6 Function : Sequence-specific transcription factor which is part of a developmental regulatory system that provides cellswith specific positional identities on the anterior-posterior axis
Genatlas biochemistry entry for HOXC10 : homeo box C10(3I),homologous to mouse Hox-3.6,involved in mouse posterior limb patterning,expressed in posterior limb Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HOXC10 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HOXC10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: HOXC10 (NM_017409 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HOXC10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HOXC10
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC10
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 sequence-specific DNA binding transcription factor activity
IEA -- GO:0043565 sequence-specific DNA binding
IEA --
HOXC10 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for HOXC10 :Animal Models: Mouse knock-out Hoxc10 tm1Mrc for HOXC10 7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hoxc10) :
HOXC10 for phenotypes About GeneDecksing
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Pathways & Interactionsfor HOXC10 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXC10 STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)5/6 Interacting proteins for HOXC10 (Q9NYD6 3 ENSP00000307321 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0001501 skeletal system development
IEA -- GO:0006351 transcription, DNA-dependent
IEA -- GO:0008284 positive regulation of cell proliferation
TAS 10835276 GO:0009952 anterior/posterior pattern specification
IEA -- GO:0009954 proximal/distal pattern formation
IEA --
HOXC10 for ontologies About GeneDecksing
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Drugs & Compoundsfor HOXC10 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for HOXC10 Search CenterWatch for drugs/clinical trials and news about HOXC10 / HXC10
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Transcriptsfor HOXC10 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for HOXC10 gene: NM_017409.3 Unigene Cluster for HOXC10:
Homeobox C10 Hs.44276 [show with all ESTs ] Unigene Representative Sequence: NM_017409 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000515593 ENST00000303460 (uc001sen.3 ) ENST00000511575 ENST00000514415 ENST00000513413 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HOXC10 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HOXC10OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: HOXC10 (NM_017409 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HOXC10 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HOXC10
Additional cDNA sequence: AF255675.1 AK313759.1 BC001293.1 BT009921.1 X99685.1
3 DOTS entries : DT.448032 DT.91692757
DT.95307803 24/228 AceView cDNA sequences (see all 228 ):
NM_153633 AI380130 CR622939 BC074845 AA888101 BF057562 BE464190 AL558161 NM_004503 BM832772 BM758123 AI215607 AI174335 BM825403 BQ684698 AA158947 BM127322 BQ890449 AA813478 BX280842 BQ949038 BM836024 AW299598 AA629181 GeneLoc Exon Structure
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Expression for HOXC10 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section HOXC10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAGCTTCCTT
About this image HOXC10 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See HOXC10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for HOXC10 SOURCE GeneReport for Unigene cluster: Hs.44276 SABiosciences Expression via Pathway-Focused PCR Arrays including HOXC10 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for HOXC10Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat HOXC10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat HOXC10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat HOXC10 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC10
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Orthologsfor HOXC10 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for HOXC10 gene from 5/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for HOXC10 (if available)TreeFam Gene Tree for HOXC10 (if available)
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Paralogsfor HOXC10 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for HOXC10 gene HOXA9 2 HOXA13 2 HOXC9 2 HOXD11 2 HOXC12 2 ENSG00000257184 2 HOXB13 2 HOXD10 2 HOXC11 2 HOXA11 2 HOXD13 2 HOXC13 2 HOXB9 2 HOXD9 2 HOXD12 2 HOXA10 2 4 SIMAP similar genes for HOXC10 using alignment to 3 protein entries: HXC10_HUMAN (see all proteins ):HOXD10 HOXA10 HOXA9 HOXC9
HOXC10 for paralogs About GeneDecksing
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Genomic Variantsfor HOXC10 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for HOXC10 (54378849 - 54384063 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for HOXC10 1 CNV : 3890
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing HOXC10
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Disorders
/ Diseasesfor HOXC10 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
HOXC10 for disorders About GeneDecksing
OMIM gene information: 605560
OMIM disorders : --6 diseases for HOXC10 : About MalaCards cervical squamous cell carcinoma squamous cell carcinoma cervicitis lung carcinoma carcinoma neuronitis Export disorders for HOXC10 gene to outside databases
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Publicationsfor HOXC10 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for HOXC10 gene, integrated from 9 sources (see all 19 ): (articles sorted by number of sources associating them with HOXC10) Utopia : connect your pdf to the dynamic world of online information
Selection of homeotic proteins for binding to a human DNA replication origin. (PubMed id 10835276) 1 , 2 , 9 de Stanchina E.... Biamonti G. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PubMed id 9357979) 1 , 2 Flagiello D.... Malfoy B. (1997) Vertebrate homeobox gene nomenclature. (PubMed id 1358459) 1 , 3 Scott M.P. (1992) Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. (PubMed id 17974957) 1 , 9 Zhai Y....Cho K.R. (2007) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764) 1 Tatham M.H....Hay R.T. (2011) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022) 1 Golebiowski F....Hay R.T. (2009) HOXC10 as a potential marker for discriminating betwe en amnion- and decidua-derived mesenchymal stem cells. (PubMed id 19522674) 1 Hwang J.H....Lee J.K. (2009)
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External Searches for HOXC10 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing HOXC10 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing HOXC10 gene
(According to HUGE )
About This Section --
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Specialized Databases showing HOXC10 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for HOXC10 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for HOXC10 gene: Search GeneIP for patents involving HOXC10 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor HOXC10 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for HOXC10 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for HOXC10 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for HOXC10 OriGene Protein Over-expression Lysate for HOXC10 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for HOXC10 OriGene 3'-UTR Clone for HOXC10 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for HOXC10 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for HOXC10 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for HOXC10 OriGene Custom Protein Services for HOXC10 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HOXC10 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing HOXC10 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat HOXC10 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat HOXC10 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat HOXC10 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat HOXC10
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HOXC10 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXC10
Search ThermoFisher Antibodies for HOXC10
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat HOXC10
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