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Aliases for HOXC10 Gene

Aliases for HOXC10 Gene

  • Homeobox C10 2 3
  • Homeobox Protein Hox-3I 3 4
  • Homeo Box C10 2 3
  • HOX3I 3 4
  • Homeobox Protein Hox-C10 3
  • Homeoprotein C10 3

External Ids for HOXC10 Gene

Previous HGNC Symbols for HOXC10 Gene

  • HOX3I

Previous GeneCards Identifiers for HOXC10 Gene

  • GC12M054414
  • GC12P054491
  • GC12P054095
  • GC12P052665
  • GC12P054378
  • GC12P051416

Summaries for HOXC10 Gene

Entrez Gene Summary for HOXC10 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC10 Gene

HOXC10 (Homeobox C10) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXC10 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC10 Gene

Genomics for HOXC10 Gene

Regulatory Elements for HOXC10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXC10 Gene

Start:
53,985,065 bp from pter
End:
53,990,279 bp from pter
Size:
5,215 bases
Orientation:
Plus strand

Genomic View for HOXC10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC10 Gene

Proteins for HOXC10 Gene

  • Protein details for HOXC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYD6-HXC10_HUMAN
    Recommended name:
    Homeobox protein Hox-C10
    Protein Accession:
    Q9NYD6
    Secondary Accessions:
    • O15219
    • O15220
    • Q9BVD5

    Protein attributes for HOXC10 Gene

    Size:
    342 amino acids
    Molecular mass:
    38073 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC10 Gene

Proteomics data for HOXC10 Gene at MOPED

Post-translational modifications for HOXC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXC10 Gene

Domains for HOXC10 Gene

Gene Families for HOXC10 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for HOXC10 Gene

Suggested Antigen Peptide Sequences for HOXC10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYD6

UniProtKB/Swiss-Prot:

HXC10_HUMAN :
  • Q9NYD6
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXC10: view

Function for HOXC10 Gene

Molecular function for HOXC10 Gene

GENATLAS Biochemistry:
homeo box C10(3I),homologous to mouse Hox-3.6,involved in mouse posterior limb patterning,expressed in posterior limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXC10: view
genes like me logo Genes that share phenotypes with HOXC10: view

Animal Models for HOXC10 Gene

MGI Knock Outs for HOXC10:

Animal Model Products

miRNA for HOXC10 Gene

miRTarBase miRNAs that target HOXC10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXC10 Gene

Localization for HOXC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXC10 Gene COMPARTMENTS Subcellular localization image for HOXC10 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0019907 colocalizes_with cyclin-dependent protein kinase activating kinase holoenzyme complex IDA 11445587
genes like me logo Genes that share ontologies with HOXC10: view

Pathways for HOXC10 Gene

SuperPathways for HOXC10 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HOXC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008284 positive regulation of cell proliferation TAS 10835276
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXC10: view

No data available for Pathways by source for HOXC10 Gene

Transcripts for HOXC10 Gene

Unigene Clusters for HOXC10 Gene

Homeobox C10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXC10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC10 Gene

No ASD Table

Relevant External Links for HOXC10 Gene

GeneLoc Exon Structure for
HOXC10
ECgene alternative splicing isoforms for
HOXC10

Expression for HOXC10 Gene

mRNA expression in normal human tissues for HOXC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC10 Gene

This gene is overexpressed in Muscle - Skeletal (16.5), Kidney - Cortex (5.4), and Artery - Tibial (5.4).

Protein differential expression in normal tissues for HOXC10 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXC10 Gene

SOURCE GeneReport for Unigene cluster for HOXC10 Gene Hs.44276

genes like me logo Genes that share expressions with HOXC10: view

Expression partners for HOXC10 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXC10 Gene

Orthologs for HOXC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXC10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXC10 35
  • 96.09 (n)
  • 97.15 (a)
HOXC10 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXC10 35
  • 93.47 (n)
  • 94.44 (a)
HOXC10 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxc10 35
  • 95.22 (n)
  • 97.37 (a)
Hoxc10 16
Hoxc10 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXC10 35
  • 99.71 (n)
  • 99.42 (a)
HOXC10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxc10 35
  • 95.32 (n)
  • 97.37 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXC10 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXC10 35
  • 73.2 (n)
  • 73.98 (a)
HOXC10 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXC10 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc10 35
  • 71.46 (n)
  • 70.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21864 35
zebrafish
(Danio rerio)
Actinopterygii hoxc10a 35
  • 54.22 (n)
  • 51.62 (a)
hoxc10a 36
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14322 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
OneToMany
Species with no ortholog for HOXC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC10 Gene

ENSEMBL:
Gene Tree for HOXC10 (if available)
TreeFam:
Gene Tree for HOXC10 (if available)

Paralogs for HOXC10 Gene

Selected SIMAP similar genes for HOXC10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXC10: view

Variants for HOXC10 Gene

Sequence variations from dbSNP and Humsavar for HOXC10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4237810 -- 53,989,716(-) GAGGG(C/T)TTGAC utr-variant-3-prime
rs34502762 -- 53,988,808(+) TTTTT(-/C)CCAGA intron-variant
rs35616568 -- 53,989,509(+) TGTGC(C/G)TGGTG utr-variant-3-prime
rs56841354 -- 53,987,939(+) ATTCA(A/G)ATTTT intron-variant
rs66607550 -- 53,987,940(+) TTCAG(-/A)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXC10 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914

Relevant External Links for HOXC10 Gene

HapMap Linkage Disequilibrium report
HOXC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXC10 Gene

Disorders for HOXC10 Gene

No disorders were found for HOXC10 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HOXC10 Gene

Publications for HOXC10 Gene

  1. Selection of homeotic proteins for binding to a human DNA replication origin. (PMID: 10835276) de Stanchina E. … Biamonti G. (J. Mol. Biol. 2000) 3 4 23
  2. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. (PMID: 17974957) Zhai Y. … Cho K.R. (Cancer Res. 2007) 3 23
  3. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  4. Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. (PMID: 9357979) Flagiello D. … Malfoy B. (FEBS Lett. 1997) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HOXC10 Gene

Sources for HOXC10 Gene

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