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Aliases for HOXC10 Gene

Aliases for HOXC10 Gene

  • Homeobox C10 2 3 5
  • Homeobox Protein Hox-3I 3 4
  • Homeo Box C10 2 3
  • HOX3I 3 4
  • Homeoprotein C10 3

External Ids for HOXC10 Gene

Previous HGNC Symbols for HOXC10 Gene

  • HOX3I

Previous GeneCards Identifiers for HOXC10 Gene

  • GC12M054414
  • GC12P054491
  • GC12P054095
  • GC12P052665
  • GC12P054378
  • GC12P051416
  • GC12P053987
  • GC12P053989

Summaries for HOXC10 Gene

Entrez Gene Summary for HOXC10 Gene

  • This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXC10 Gene

HOXC10 (Homeobox C10) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXC10 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXC10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXC10 Gene

Genomics for HOXC10 Gene

Regulatory Elements for HOXC10 Gene

Enhancers for HOXC10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HOXC10 on UCSC Golden Path with GeneCards custom track

Promoters for HOXC10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HOXC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXC10 Gene

53,985,065 bp from pter
53,990,279 bp from pter
5,215 bases
Plus strand

Genomic View for HOXC10 Gene

Genes around HOXC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXC10 Gene

Proteins for HOXC10 Gene

  • Protein details for HOXC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Hox-C10
    Protein Accession:
    Secondary Accessions:
    • O15219
    • O15220
    • Q9BVD5

    Protein attributes for HOXC10 Gene

    342 amino acids
    Molecular mass:
    38073 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXC10 Gene

Proteomics data for HOXC10 Gene at MOPED

Post-translational modifications for HOXC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXC10 Gene

Domains & Families for HOXC10 Gene

Gene Families for HOXC10 Gene

Protein Domains for HOXC10 Gene

Suggested Antigen Peptide Sequences for HOXC10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXC10: view

Function for HOXC10 Gene

Molecular function for HOXC10 Gene

GENATLAS Biochemistry:
homeo box C10(3I),homologous to mouse Hox-3.6,involved in mouse posterior limb patterning,expressed in posterior limb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
genes like me logo Genes that share phenotypes with HOXC10: view

Animal Models for HOXC10 Gene

MGI Knock Outs for HOXC10:

Animal Model Products

miRNA for HOXC10 Gene

miRTarBase miRNAs that target HOXC10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXC10 Gene

Localization for HOXC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXC10 Gene

Subcellular locations from

Jensen Localization Image for HOXC10 Gene COMPARTMENTS Subcellular localization image for HOXC10 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXC10 Gene

Pathways & Interactions for HOXC10 Gene

SuperPathways for HOXC10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0030326 embryonic limb morphogenesis IEA --
GO:0050905 neuromuscular process IEA --
genes like me logo Genes that share ontologies with HOXC10: view

No data available for Pathways by source and SIGNOR curated interactions for HOXC10 Gene

Drugs & Compounds for HOXC10 Gene

No Compound Related Data Available

Transcripts for HOXC10 Gene

Unigene Clusters for HOXC10 Gene

Homeobox C10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXC10 Gene

No ASD Table

Relevant External Links for HOXC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOXC10 Gene

mRNA expression in normal human tissues for HOXC10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXC10 Gene

This gene is overexpressed in Muscle - Skeletal (x16.5), Kidney - Cortex (x5.4), and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for HOXC10 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXC10 Gene

SOURCE GeneReport for Unigene cluster for HOXC10 Gene Hs.44276

genes like me logo Genes that share expression patterns with HOXC10: view

Protein tissue co-expression partners for HOXC10 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HOXC10 Gene

Orthologs for HOXC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HOXC10 35
  • 96.09 (n)
  • 97.15 (a)
HOXC10 36
  • 95 (a)
(Canis familiaris)
Mammalia HOXC10 35
  • 93.47 (n)
  • 94.44 (a)
HOXC10 36
  • 94 (a)
(Mus musculus)
Mammalia Hoxc10 35
  • 95.22 (n)
  • 97.37 (a)
Hoxc10 16
Hoxc10 36
  • 97 (a)
(Pan troglodytes)
Mammalia HOXC10 35
  • 99.71 (n)
  • 99.42 (a)
HOXC10 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hoxc10 35
  • 95.32 (n)
  • 97.37 (a)
(Ornithorhynchus anatinus)
Mammalia HOXC10 36
  • 73 (a)
(Gallus gallus)
Aves HOXC10 35
  • 73.2 (n)
  • 73.98 (a)
HOXC10 36
  • 91 (a)
(Anolis carolinensis)
Reptilia HOXC10 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxc10 35
  • 71.46 (n)
  • 70.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.21864 35
(Danio rerio)
Actinopterygii hoxc10a 35
  • 54.22 (n)
  • 51.62 (a)
hoxc10a 36
  • 39 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14322 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
Species with no ortholog for HOXC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXC10 Gene

Gene Tree for HOXC10 (if available)
Gene Tree for HOXC10 (if available)

Paralogs for HOXC10 Gene

(4) SIMAP similar genes for HOXC10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXC10: view

Variants for HOXC10 Gene

Sequence variations from dbSNP and Humsavar for HOXC10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs34502762 -- 53,988,808(+) TTTTT(-/C)CCAGA intron-variant
rs111908518 -- 53,987,940(+) TTCAG(A/T)TTTTT intron-variant
rs35616568 -- 53,989,509(+) TGTGC(C/G)TGGTG utr-variant-3-prime
rs192890952 -- 53,987,861(+) ACGTA(A/G)TTAGA intron-variant
rs112671098 -- 53,989,048(+) CCCCT(A/G)GGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXC10 Gene

Variant ID Type Subtype PubMed ID
nsv826379 CNV Gain 20364138
nsv899100 CNV Loss 21882294
dgv512e1 CNV Complex 17122850
nsv428282 CNV Gain 18775914

Variation tolerance for HOXC10 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HOXC10 Gene

Disorders for HOXC10 Gene

Relevant External Links for HOXC10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HOXC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXC10 Gene

Publications for HOXC10 Gene

  1. Selection of homeotic proteins for binding to a human DNA replication origin. (PMID: 10835276) de Stanchina E. … Biamonti G. (J. Mol. Biol. 2000) 3 4 23 67
  2. Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion. (PMID: 17974957) Zhai Y. … Cho K.R. (Cancer Res. 2007) 3 23
  3. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  4. The Dual Estrogen Receptor I+ Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety. (PMID: 26487511) Han S.J. … O'Malley B.W. (Mol. Pharmacol. 2016) 3
  5. Anterior migration of lateral plate mesodermal cells during embryogenesis of the pufferfish Takifugu niphobles: insight into the rostral positioning of pelvic fins. (PMID: 26018586) Tanaka M. … Kurokawa D. (J. Anat. 2015) 3

Products for HOXC10 Gene

Sources for HOXC10 Gene