Aliases for HOXB9 Gene
Aliases for HOXB9 Gene
External Ids for HOXB9 Gene
- HGNC: 5120
- Entrez Gene: 3219
- Ensembl: ENSG00000170689
- OMIM: 142964
- UniProtKB: P17482
Previous HGNC Symbols for HOXB9 Gene
- HOX2E
- HOX2
Previous GeneCards Identifiers for HOXB9 Gene
- GC17M046409
- GC17M049179
- GC17M047040
- GC17M047173
- GC17M044053
- GC17M046694
- GC17M042067
Summaries for HOXB9 Gene
-
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB9 Gene
HOXB9 (Homeobox B9) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXA9.
UniProtKB/Swiss-Prot for HOXB9 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB9 Gene
Genomics for HOXB9 Gene
Regulatory Elements for HOXB9 Gene
Enhancers for HOXB9 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXB9 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXB9 gene promoter:
Regulatory Element Products
Genomic Location for HOXB9 Gene
- Chromosome:
- 17
- Start:
- 48,615,128 bp from pter
- End:
- 48,626,473 bp from pter
- Size:
- 11,346 bases
- Orientation:
- Minus strand
Genomic View for HOXB9 Gene
Genes around HOXB9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
HOXB9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXB9 Gene
Proteins for HOXB9 Gene
-
Protein details for HOXB9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17482-HXB9_HUMAN
- Recommended name:
- Homeobox protein Hox-B9
- Protein Accession:
- P17482
- B2RDB7
- Q9H1I1
Protein attributes for HOXB9 Gene
- Size:
- 250 amino acids
- Molecular mass:
- 28059 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXB9 Gene
Post-translational modifications for HOXB9 Gene
Other Protein References for HOXB9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOXB9
- Novus Biologicals Antibodies for HOXB9
-
Abcam antibodies for HOXB9
- Invitrogen Antibodies for HOXB9
- antibodies-online Antibodies for HOXB9: See all 72
- GeneTex HOXB9 antibody for HOXB9
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXB9
Protein Products
-
OriGene Purified Proteins for HOXB9
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXB9
- Origene Custom Protein Services for HOXB9
- antibodies-online Proteins for HOXB9: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXB9
-
Abcam proteins for HOXB9
Assay Products
- antibodies-online Kits for HOXB9: See all 1
No data available for DME Specific Peptides for HOXB9 Gene
Domains & Families for HOXB9 Gene
Gene Families for HOXB9 Gene
Protein Domains for HOXB9 Gene
Suggested Antigen Peptide Sequences for HOXB9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17482- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXB9 Gene
Molecular function for HOXB9 Gene
- GENATLAS Biochemistry:
- homeo box B9(2E),homologous to mouse Hox-2.5,Drosophila abd-B
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 10617598 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXB9 Gene
- MGI mutant phenotypes for HOXB9:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXB9:
Animal Models for HOXB9 Gene
- MGI Knock Outs for HOXB9:
-
- Hoxb9 tm1Mrc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB9 gene
- Search ViGene Biosciences for HOXB9
CRISPR Products
-
OriGene CRISPR knockouts for HOXB9
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB9
- GenScript: Design CRISPR guide RNA sequences for HOXB9
miRNA for HOXB9 Gene
- miRTarBase miRNAs that target HOXB9
miRNA Products
- Search ViGene Biosciences for HOXB9
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB9
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB9 gene
Clone Products
-
OriGene ORF clones in human for HOXB9
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Cell Line Products
-
Horizon Cell Lines for HOXB9
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXB9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB9 gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10733) for HOXB9
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB9 Gene
Localization for HOXB9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXB9 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005739 | mitochondrion | IDA | -- |
Pathways & Interactions for HOXB9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cyclins and Cell Cycle Regulation | ||
Pathways by source for HOXB9 Gene
1 Qiagen pathway for HOXB9 Gene
Interacting Proteins for HOXB9 Gene
Selected Interacting proteins:
P17482-HXB9_HUMAN
ENSP00000309439
for HOXB9 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
| GO:0030879 | mammary gland development | IEA | -- |
No data available for SIGNOR curated interactions for HOXB9 Gene
Transcripts for HOXB9 Gene
mRNA/cDNA for HOXB9 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (82) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXB9
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB9
- GenScript: Design CRISPR guide RNA sequences for HOXB9
miRNA Products
- Search ViGene Biosciences for HOXB9
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB9
- Browse OriGene Inhibitory RNA Products For HOXB9
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB9 gene
Clone Products
-
OriGene ORF clones in human for HOXB9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXB9
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10733) for HOXB9
Expression for HOXB9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Sclerotome Cells Cervical Mesenchymal Sclerotome
- Sclerotome Cells Lumbar Mesenchymal Sclerotome
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Sclerotome Cells Cervical Mesenchymal Sclerotome
- Sclerotome Cells Lumbar Mesenchymal Sclerotome
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Somite (Muscoskeletal System)
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Sclerotome Cells Cervical Mesenchymal Sclerotome
- Sclerotome Cells Lumbar Mesenchymal Sclerotome
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Sacral Mesenchymal Sclerotome
- Sclerotome Cells Cervical Mesenchymal Sclerotome
- Sclerotome Cells Lumbar Mesenchymal Sclerotome
- Sclerotome Cells Thoracic Mesenchymal Sclerotome
-
Testis (Reproductive System)
- Sertoli cells Seminiferous Tubules
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Gut Tube (Gastrointestinal Tract)
- Prepancreatic Foregut Endoderm Cells Prepancreatic Dorsal Foregut Endoderm
-
Epithelial Cells
- Prepancreatic Foregut Endoderm Cells Prepancreatic Dorsal Foregut Endoderm
-
Pancreas (Endocrine System)
- Prepancreatic Foregut Endoderm Cells Prepancreatic Dorsal Foregut Endoderm
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Gonad
- Primordial Germ Cells Allantois
- Neural Tube (Nervous System)
-
Colon (Gastrointestinal Tract)
-
Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for HOXB9 Gene
This gene is overexpressed in Colon - Transverse (x26.4), Kidney - Cortex (x9.3), and Small Intestine - Terminal Ileum (x7.2).
This gene is overexpressed in Plasma (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB9 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXB9 Gene:
HOXB9SOURCE GeneReport for Unigene cluster for HOXB9 Gene:
Hs.463350Evidence on tissue expression from TISSUES for HOXB9 Gene
- Muscle(4.2)
- Intestine(3.1)
Primer Products
-
OriGene qPCR primer pairs for HOXB9
-
OriGene qPCR primer pairs and template standards for HOXB9
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB9 Gene
Orthologs for HOXB9 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXB9 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXB9 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXB9 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxb9 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxb9 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXB9 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXB9 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXB9 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXB9 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxb9 34 |
|
||
| MGC75797 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | hoxb9a 34 35 |
|
||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5766 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXB9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXB9 Gene
Paralogs for HOXB9 Gene
(6) SIMAP similar genes for HOXB9 Gene using alignment to 2 proteins:
Variants for HOXB9 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000123927 | -- | 48,621,676(+) | AGAAG(C/T)CGACG | utr-variant-3-prime, utr-variant-5-prime | |
| rs1000541350 | -- | 48,620,758(+) | GACAT(C/T)CTCAG | downstream-variant-500B, utr-variant-5-prime | |
| rs1000911501 | -- | 48,624,916(+) | CCTCT(C/T)CCCGG | intron-variant | |
| rs1001040440 | -- | 48,624,047(+) | CTGGA(C/G)GGGAG | intron-variant, upstream-variant-2KB | |
| rs1001216259 | -- | 48,623,526(+) | GCTCT(A/T)GGAGG | intron-variant, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv369n27 | CNV | loss | 19166990 |
| dgv5676n54 | CNV | loss | 21841781 |
| esv2758694 | CNV | gain | 17122850 |
| nsv833469 | CNV | loss | 17160897 |
| nsv833471 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.71;
46.45% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXB9 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXB9
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB9 Gene
Disorders for HOXB9 Gene
Relevant External Links for HOXB9
No disorders were found for HOXB9 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB9 Gene
Publications for HOXB9 Gene
- Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. (PMID: 19341834) Rouault K. … FAcrec C. (Osteoarthr. Cartil. 2009) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 64
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
Products for HOXB9 Gene
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- Custom Antibody ServicesOriGene Antibodies for HOXB9
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- Abcam antibodies for HOXB9
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- Search for Assays for HOXB9 at Abcam
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- antibodies-online Antibodies for HOXB9: See all 72
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- antibodies-online Proteins for HOXB9: See all 9
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- GeneTex HOXB9 antibody for HOXB9
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXB9 gene
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- Search ViGene Biosciences for HOXB9
- Santa Cruz Biotechnology (SCBT) Antibodies for HOXB9
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- VectorBuilder custom plasmid, inducible vectors for HOXB9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXB9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXB9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer