Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB9 Gene

protein-coding   GIFtS: 54
GCID: GC17M046694

homeobox B9

(Previous name: homeo box B9 )
(Previous symbols: HOX2E, HOX2)
 Explore 10 diseases affiliated with
HOXB9 via our new
 Human Malady Compendium 
Biological research products
for HOXB9
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Homeobox B91 2     Homeobox Protein Hox-2E2 3
HOX2E1 2 3 5     HOX-2.52
HOX21 2     Homeo Box 2E2
Homeo Box B91 2     Homeobox Protein Hox-B92
Homeobox Protein Hox-2.52 3     

External Ids:    HGNC: 51201   Entrez Gene: 32192   Ensembl: ENSG000001706897   OMIM: 1429645   UniProtKB: P174823   

Export aliases for HOXB9 gene to outside databases

Previous GC identifers: GC17M046409 GC17M049179 GC17M047040 GC17M047173 GC17M044053 GC17M042067


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXB9:
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a
sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased
expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXB9_HUMAN, P17482
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB9


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB9 gene promoter:
         E2F-4   E2F-3a   E2F-5   AML1a   E2F-2   E2F   E2F-1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB9 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB9 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046694:  view genomic region     (about GC identifiers)

Start:
46,698,518 bp from pter      End:
46,703,839 bp from pter
Size:
5,322 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HXB9_HUMAN, P17482 (See protein sequence)
Recommended Name: Homeobox protein Hox-B9  
Size: 250 amino acids; 28059 Da
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: B2RDB7 Q9H1I1

Explore the universe of human proteins at neXtProt for HOXB9: NX_P17482

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17482

  • HOXB9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_076922.1  
    ENSEMBL proteins: 
     ENSP00000309439   ENSP00000447530  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HOXB9
    OriGene Custom Protein Services for HOXB9 
    GenScript Custom Purified and Recombinant Proteins Services for HOXB9
    Novus Biologicals HOXB9 Proteins
    Novus Biologicals HOXB9 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXB9

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--


    HOXB9 for ontologies           About GeneDecksing



    HOXB9 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: HOXB9
    OriGene Custom Antibody Services for HOXB9 
    GenScript Custom Superior Antibodies Services for HOXB9
    Novus Biologicals HOXB9 Antibodies
    Abcam antibodies for HOXB9 
    Uscn Antibodies for HOXB9
    ThermoFisher Antibodies for HOXB9

    Assay Products for HOXB9: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXB9
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HOXB9


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HOXB9 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR020479 Homeobox_metazoa
     IPR006711 Hox9_activation_N
     IPR017112 Homeobox_Hox9
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P17482

    ProtoNet protein and cluster: P17482

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB006711 Hox9 activation region


    UniProtKB/Swiss-Prot: HXB9_HUMAN, P17482
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HXB9_HUMAN, P17482
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB9:
    homeo box B9(2E),homologous to mouse Hox-2.5,Drosophila abd-B

    miRNA
    Products:
        
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB9
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB9 (see all 23):
    hsa-miR-3689b hsa-miR-4286 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-4305 hsa-miR-339-5p hsa-miR-570 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHOXB9 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB9 (see all 7)
    OriGene shRNA RFP: HOXB9
    OriGene siRNA: HOXB9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB9

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HOXB9

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB9
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXB9 (NM_024017)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB9 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HOXB9
    Search LifeMap BioReagents cell lines for HOXB9

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB9

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0005515protein binding IPI19060904
    GO:0043565sequence-specific DNA binding IEA--


    HOXB9 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hoxb9tm1Mrc for HOXB9
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hoxb9):
     endocrine/exocrine gland  hematopoietic system  immune system  integument  limbs/digits/tail 
     skeleton 

    HOXB9 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cyclins and Cell Cycle Regulation
    Cell Cycle Control by BTG Proteins0.36

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for HOXB9
        Cell Cycle Control by BTG Proteins


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/19 Interacting proteins for HOXB9 (P174821, 2, 3 ENSP000003094394) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216731, 2, 3, ENSP000003685724EBI-745290,EBI-711613 MINT-68157 I2D: score=5 STRING: ENSP00000368572
    RBPMSQ930622, 3, ENSP000003401764MINT-67929 I2D: score=5 STRING: ENSP00000340176
    MDFIQ997501, 2, 3, ENSP000002303214EBI-745290,EBI-724076 MINT-67244 I2D: score=5 STRING: ENSP00000230321
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-66644 I2D: score=5 STRING: ENSP00000377582
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS--
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0030879mammary gland development IEA--


    HOXB9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB9
    Search CenterWatch for drugs/clinical trials and news about HOXB9 / HXB9 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXB9 gene: 
    NM_024017.4  

    Unigene Cluster for HOXB9:

    Homeobox B9
    Hs.463350  [show with all ESTs]
    Unigene Representative Sequence: NM_024017
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000311177(uc002inx.3) ENST00000550387

    miRNA
    Products:
         
    Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB9
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB9 (see all 23):
    hsa-miR-3689b hsa-miR-4286 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-4305 hsa-miR-339-5p hsa-miR-570 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHOXB9 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB9 (see all 7)
    OriGene shRNA RFP: HOXB9
    OriGene siRNA: HOXB9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB9
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB9 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB9
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXB9 (NM_024017)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB9 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB9

    Additional cDNA sequence: 

    AK026084.1 AK056123.1 AK315480.1 BC015565.1 

    3 DOTS entries:

    DT.309741  DT.100749432  DT.100749433 

    24/82 AceView cDNA sequences (see all 82):

    BF063337 AW973279 BM784270 BX114117 AW078582 BC015565 BF478046 BE350818 
    BM987589 NM_024017 AI352287 AI343498 BQ219022 BG328517 AI695505 AA551797 
    AA706441 AW881257 BG830524 BF939270 AW372642 BE869771 AI761312 AK026084 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCCTGGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    HOXB9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    PancreasPrepancreatic Dorsal Foregut EndodermPre-Pancreatic Foregut Endoderm CellsPancreas
    SomiteCervical Mesenchymal SclerotomeCervical Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteLumbar Mesenchymal SclerotomeLumbar Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteSacral Mesencymal SclerotomeSacral Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    SomiteThoracic Mesenchymal SclerotomeThoracic Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    TestisSeminiferous TubulesSertoli cellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HOXB9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB9

    SOURCE GeneReport for Unigene cluster: Hs.463350
        SABiosciences Expression via Pathway-Focused PCR Array including HOXB9: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB9
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB9
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB9
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB9
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXB9 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HOXB91 homeobox B9 78.81(n)
    82.52(a)
      771865  XM_001233690.2  XP_001233691.2 
    lizard
    (Anolis carolinensis)
    Reptilia HOXB96
    HOXD96
    --
    74(a)
    19(a)
    1 ↔ 1
    possible ortholog
    6(75640473-75645469)
    GL343356.1(518262-536480)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC757972 hypothetical protein MGC75797 77.67(n)    BC059757.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxb9a2 homeo box B9a 80.27(n)   30344  AY391430.1 
    worm
    (Caenorhabditis elegans)
    Secernentea nob-16
    kNOB-like posterior (NO Backside) family member (n...
    15(a)
    1 → many
    III(12077688-12084220)


    ENSEMBL Gene Tree for HOXB9 (if available)
    TreeFam Gene Tree for HOXB9 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB9 gene
    HOXA92  HOXA132  HOXC92  HOXD112  HOXC122  ENSG000002571842  HOXB132  HOXD102  
    HOXC112  HOXA112  HOXD132  HOXC132  HOXC102  HOXD92  HOXD122  HOXA102  
    6 SIMAP similar genes for HOXB9 using alignment to 2 protein entries:     HXB9_HUMAN (see all proteins):
    HOXA-9    HOXA10    HOXC9    HOXA9    HOXD9    HOXA11

    HOXB9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/128 NCBI SNPs in HOXB9 are shown (see all 128    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs780010991,2
    C,--46698076(+) GTGTTC/GCTCCC 1 -- ds50013Minor allele frequency- G:0.12NA EA 242
    rs1472964111,2
    --46698116(+) AGGTGA/GCATTC 1 -- ds50010--------
    rs620645681,2
    C,F,--46698228(+) CCAGAC/TCCTGT 1 -- ds50019Minor allele frequency- T:0.31NA WA CSA EA 370
    rs28758191,2
    F,--46698492(+) AGAGCC/TAACAC 1 -- ds50011Minor allele frequency- T:0.04WA 118
    rs739858861,2
    C,F,--46698610(+) CCCACT/CCCCAC 1 -- ut314Minor allele frequency- C:0.07WA NA 242
    rs88441,2
    C,F,O,H,--46698710(-) TTGTCG/AGTGGC 1 -- ut31 ese315Minor allele frequency- A:0.08MN NS EA NA 2118
    rs38265411,2
    C,--46698956(-) GGCTTG/TGCCTC 1 -- ut31 ese33Minor allele frequency- T:0.12NA EA 242
    rs38265401,2
    C,--46699018(-) CAGAGA/GAGCCC 1 -- ut31 ese33Minor allele frequency- G:0.12NA EA 242
    rs1175138011,2
    F,--46699071(+) CGTTGC/AGCGCT 1 -- ut311Minor allele frequency- A:0.03EA 120
    rs1864571421,2
    --46699188(+) TACAGG/TGGGGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HOXB9 (46698518 - 46703839 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HOXB9
         2 CNVs: 53230 4040

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB9
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXB9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HOXB9 for disorders           About GeneDecksing

    OMIM gene information: 142964    OMIM disorders: --

    10 diseases for HOXB9:    About MalaCards
    prostate cancer    lung cancer    prostatitis    leukemia
    hodgkin's lymphoma    lung adenoma    breast cancer    adenoma
    neuroblastoma    adenocarcinoma

    Human Genome Epidemiology (HuGE) Navigator: HOXB9 (1 document)

    Export disorders for HOXB9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB9 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with HOXB9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    4. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    6. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
    7. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    8. HOXB9 expression promoting tumor cell proliferation an d angiogenesis is associated with clinical outcomes in breast cancer patients. (PubMed id 22396001)1 Seki H....Kitagawa Y. (2012)
    9. Silencing of homeobox B9 is associated with down-regul ation of CD56 and extrathyroidal extension of tumor in papillary thyroid carcino ma. (PubMed id 22225776)1 Kim J.H....Park T.J. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3219 HGNC: 5120 AceView: HOXB9 Ensembl:ENSG00000170689 euGenes: HUgn3219
    ECgene: HOXB9 H-InvDB: HOXB9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXB9 gene:
    Search GeneIP for patents involving HOXB9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for HOXB9   OriGene shRNA RFP for HOXB9  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB9   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB9  
     OriGene Protein Over-expression Lysate for HOXB9   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HOXB9   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB9   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB9  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXB9   OriGene Custom Protein Services for HOXB9  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HOXB9
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB9
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB9
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB9
     GenScript Custom Purified and Recombinant Proteins Services for HOXB9 GenScript cDNA clones with any tag delivered in your preferred vector for HOXB9
     GenScript Custom Assay Services for HOXB9 GenScript Custom Superior Antibodies Services for HOXB9
     GenScript Custom overexpressing Cell Line Services for HOXB9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXB9 promoter
     Search Chromatin IP Primers for HOXB9
     RT2 qPCR Primer Assay in human, mouse, rat HOXB9
     GNC Network for HOXB9
     SABiosciences PCR Arrays including human, mouse, rat HOXB9
     Search Tocris compounds for HOXB9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HOXB9 antibodies
     HOXB9 proteins
     HOXB9 lysates
     Antibodies for HOXB9
     See all of Abcam's Antibodies, Kits and Proteins for HOXB9
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HOXB9 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HOXB9
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB9
     SwitchGear 3'UTR luciferase reporter plasmids for HOXB9
     SwitchGear Promoter luciferase reporter plasmids for HOXB9
     ThermoFisher Antibodies for HOXB9
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB9
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HOXB9 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4