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Aliases for HOXB9 Gene

Aliases for HOXB9 Gene

  • Homeobox B9 2 3 5
  • Homeobox Protein Hox-2.5 3 4
  • Homeobox Protein Hox-2E 3 4
  • Homeo Box B9 2 3
  • HOX2E 3 4
  • Homeo Box 2E 3
  • HOX-2.5 3
  • HOX2 3

External Ids for HOXB9 Gene

Previous HGNC Symbols for HOXB9 Gene

  • HOX2E
  • HOX2

Previous GeneCards Identifiers for HOXB9 Gene

  • GC17M046409
  • GC17M049179
  • GC17M047040
  • GC17M047173
  • GC17M044053
  • GC17M046694
  • GC17M042067

Summaries for HOXB9 Gene

Entrez Gene Summary for HOXB9 Gene

  • This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB9 Gene

HOXB9 (Homeobox B9) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXB9 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB9 Gene

Genomics for HOXB9 Gene

Regulatory Elements for HOXB9 Gene

Enhancers for HOXB9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HOXB9 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXB9 Gene

48,615,128 bp from pter
48,626,473 bp from pter
11,346 bases
Minus strand

Genomic View for HOXB9 Gene

Genes around HOXB9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB9 Gene

Proteins for HOXB9 Gene

  • Protein details for HOXB9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Hox-B9
    Protein Accession:
    Secondary Accessions:
    • B2RDB7
    • Q9H1I1

    Protein attributes for HOXB9 Gene

    250 amino acids
    Molecular mass:
    28059 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB9 Gene

Proteomics data for HOXB9 Gene at MOPED

Post-translational modifications for HOXB9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB9 Gene

Domains & Families for HOXB9 Gene

Gene Families for HOXB9 Gene

Suggested Antigen Peptide Sequences for HOXB9 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXB9: view

Function for HOXB9 Gene

Molecular function for HOXB9 Gene

GENATLAS Biochemistry:
homeo box B9(2E),homologous to mouse Hox-2.5,Drosophila abd-B
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
genes like me logo Genes that share phenotypes with HOXB9: view

Animal Models for HOXB9 Gene

MGI Knock Outs for HOXB9:

Animal Model Products

miRNA for HOXB9 Gene

miRTarBase miRNAs that target HOXB9

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB9 Gene

Localization for HOXB9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB9 Gene

Subcellular locations from

Jensen Localization Image for HOXB9 Gene COMPARTMENTS Subcellular localization image for HOXB9 gene
Compartment Confidence
mitochondrion 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXB9 Gene

Pathways & Interactions for HOXB9 Gene

genes like me logo Genes that share pathways with HOXB9: view

Pathways by source for HOXB9 Gene

1 Qiagen pathway for HOXB9 Gene

Gene Ontology (GO) - Biological Process for HOXB9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009952 anterior/posterior pattern specification IEA --
GO:0030879 mammary gland development IEA --
GO:0060070 canonical Wnt signaling pathway IMP 19576624
GO:0060326 cell chemotaxis IDA 19576624
genes like me logo Genes that share ontologies with HOXB9: view

No data available for SIGNOR curated interactions for HOXB9 Gene

Drugs & Compounds for HOXB9 Gene

No Compound Related Data Available

Transcripts for HOXB9 Gene

mRNA/cDNA for HOXB9 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(82) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXB9 Gene

Homeobox B9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB9 Gene

No ASD Table

Relevant External Links for HOXB9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOXB9 Gene

mRNA expression in normal human tissues for HOXB9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB9 Gene

This gene is overexpressed in Colon - Transverse (x26.4), Kidney - Cortex (x9.3), and Small Intestine - Terminal Ileum (x7.2).

Protein differential expression in normal tissues from HIPED for HOXB9 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB9 Gene

SOURCE GeneReport for Unigene cluster for HOXB9 Gene Hs.463350

genes like me logo Genes that share expression patterns with HOXB9: view

Protein tissue co-expression partners for HOXB9 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HOXB9 Gene

Orthologs for HOXB9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXB9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HOXB9 35
  • 98.4 (n)
  • 99.6 (a)
HOXB9 36
  • 100 (a)
(Canis familiaris)
Mammalia HOXB9 35
  • 98.4 (n)
  • 99.2 (a)
HOXB9 36
  • 99 (a)
(Mus musculus)
Mammalia Hoxb9 35
  • 95.87 (n)
  • 96.8 (a)
Hoxb9 16
Hoxb9 36
  • 97 (a)
(Pan troglodytes)
Mammalia HOXB9 35
  • 99.6 (n)
  • 99.6 (a)
HOXB9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hoxb9 35
  • 95.47 (n)
  • 96.8 (a)
(Monodelphis domestica)
Mammalia HOXB9 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia HOXB9 36
  • 84 (a)
(Gallus gallus)
Aves HOXB9 35
  • 78.81 (n)
  • 82.52 (a)
HOXB9 36
  • 78 (a)
(Anolis carolinensis)
Reptilia HOXB9 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb9 35
  • 74.04 (n)
  • 74.59 (a)
MGC75797 35
(Danio rerio)
Actinopterygii hoxb9a 35
  • 70.45 (n)
  • 73.68 (a)
hoxb9a 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5766 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
Species with no ortholog for HOXB9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB9 Gene

Gene Tree for HOXB9 (if available)
Gene Tree for HOXB9 (if available)

Paralogs for HOXB9 Gene

(6) SIMAP similar genes for HOXB9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXB9: view

Variants for HOXB9 Gene

Sequence variations from dbSNP and Humsavar for HOXB9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2303487 -- 48,627,174(+) TCCAA(G/T)AATCC upstream-variant-2KB
rs3055163 -- 48,617,549(+) AAAAA(-/AAA)CGAAA intron-variant
rs2875819 -- 48,621,130(+) AGAGC(C/T)AACAC intron-variant, downstream-variant-500B
rs3809775 -- 48,619,054(-) TTACA(C/G)GCCAT intron-variant
rs3809776 -- 48,618,761(-) GCAGA(A/C/G)CAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXB9 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990

Variation tolerance for HOXB9 Gene

Residual Variation Intolerance Score: 65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HOXB9 Gene

Disorders for HOXB9 Gene

Relevant External Links for HOXB9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HOXB9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB9 Gene

Publications for HOXB9 Gene

  1. Do HOXB9 and COL1A1 genes play a role in congenital dislocation of the hip? Study in a Caucasian population. (PMID: 19341834) Rouault K. … FAcrec C. (Osteoarthr. Cartil. 2009) 3 48 67
  2. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. HOXB9 promotes epithelial-to-mesenchymal transition via transforming growth factor-I^1 pathway in hepatocellular carcinoma cells. (PMID: 25081022) Sha L. … Ji X. (Clin. Exp. Med. 2015) 3
  5. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3

Products for HOXB9 Gene

Sources for HOXB9 Gene