Aliases for HOXB8 Gene
Aliases for HOXB8 Gene
External Ids for HOXB8 Gene
- HGNC: 5119
- Entrez Gene: 3218
- Ensembl: ENSG00000120068
- OMIM: 142963
- UniProtKB: P17481
Previous HGNC Symbols for HOXB8 Gene
- HOX2
- HOX2D
Previous GeneCards Identifiers for HOXB8 Gene
- GC17M046401
- GC17M049170
- GC17M047030
- GC17M047164
- GC17M044044
- GC17M046688
- GC17M042058
Summaries for HOXB8 Gene
-
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive-compulsive spectrum disorder trichotillomania. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB8 Gene
HOXB8 (Homeobox B8) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXC8.
UniProtKB/Swiss-Prot for HOXB8 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB8 Gene
Genomics for HOXB8 Gene
Regulatory Elements for HOXB8 Gene
Enhancers for HOXB8 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G048538 | 2.3 | VISTA FANTOM5 Ensembl ENCODE dbSUPER | 4.3 | +41.9 | 41947 | 68.8 | CREB3L1 AGO1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ZNF610 | HOXB2 SKAP1 HOXB9 HOXB3 ENSG00000264701 HOXB-AS1 HOXB-AS3 SUMO2P17 HOXB-AS4 HOXB1 |
| GH17G048623 | 1.7 | FANTOM5 ENCODE dbSUPER | 4.9 | -11.5 | -11539 | 6.4 | HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A FEZF1 ZNF766 CBX5 SP3 | ENSG00000264701 HOXB9 PRAC2 PRAC1 HOXB13 LOC105371811 HOXB2 HOXB8 HOXB5 HOXB6 |
| GH17G048608 | 1.3 | ENCODE dbSUPER | 0.7 | +1.6 | 1638 | 10.0 | HDGF PKNOX1 ARNT AGO1 SIN3A FEZF1 ZNF2 ZNF143 ZNF207 FOS | SUMO2P17 HOXB2 ENSG00000230532 SNX11 HOXB9 CALCOCO2 SCRN2 UBE2Z PIR62254 HOXB8 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXB8 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXB8 gene promoter:
Regulatory Element Products
Genomic Location for HOXB8 Gene
- Chromosome:
- 17
- Start:
- 48,611,377 bp from pter
- End:
- 48,615,112 bp from pter
- Size:
- 3,736 bases
- Orientation:
- Minus strand
Genomic View for HOXB8 Gene
Genes around HOXB8 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
HOXB8 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXB8 Gene
Proteins for HOXB8 Gene
-
Protein details for HOXB8 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17481-HXB8_HUMAN
- Recommended name:
- Homeobox protein Hox-B8
- Protein Accession:
- P17481
- Q9H1I2
Protein attributes for HOXB8 Gene
- Size:
- 243 amino acids
- Molecular mass:
- 27574 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXB8 Gene
Post-translational modifications for HOXB8 Gene
Other Protein References for HOXB8 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOXB8
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- Invitrogen Antibodies for HOXB8
- antibodies-online Antibodies for HOXB8: See all 63
- GeneTex HOXB8 antibody for HOXB8
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXB8
Protein Products
-
OriGene Purified Proteins for HOXB8
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXB8
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- antibodies-online Proteins for HOXB8: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXB8
Assay Products
- antibodies-online Kits for HOXB8: See all 2
No data available for DME Specific Peptides for HOXB8 Gene
Domains & Families for HOXB8 Gene
Gene Families for HOXB8 Gene
Protein Domains for HOXB8 Gene
Suggested Antigen Peptide Sequences for HOXB8 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17481- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXB8 Gene
Molecular function for HOXB8 Gene
- GENATLAS Biochemistry:
- homeo box B8(2D),homologous to mouse Hox-2.4,Drosophila Antp,Ubx,abd-A,involved in the establishment of anteroposterior polarity of the anterior mouse limb,controlled by SHH through a negative feedback loop
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXB8 Gene
- MGI mutant phenotypes for HOXB8:
- inferred from 9 alleles
- GenomeRNAi human phenotypes for HOXB8:
Animal Models for HOXB8 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB8 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for HOXB8
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB8
- GenScript: Design CRISPR guide RNA sequences for HOXB8
miRNA for HOXB8 Gene
- miRTarBase miRNAs that target HOXB8
-
- hsa-mir-196b-5p (MIRT001042)
- hsa-mir-196a-5p (MIRT002266)
- hsa-mir-34a-5p (MIRT025552)
- hsa-mir-320a (MIRT044624)
- hsa-mir-6770-5p (MIRT484726)
- hsa-mir-7515 (MIRT484727)
- hsa-mir-3154 (MIRT484728)
- hsa-mir-3191-3p (MIRT491459)
- hsa-mir-8052 (MIRT491460)
- hsa-mir-3199 (MIRT491461)
- hsa-mir-6787-5p (MIRT491462)
- hsa-mir-663a (MIRT491463)
- hsa-mir-1908-5p (MIRT491464)
- hsa-mir-4634 (MIRT491465)
- hsa-mir-4515 (MIRT491466)
- hsa-mir-8072 (MIRT491467)
- hsa-mir-4479 (MIRT491468)
- hsa-mir-3960 (MIRT491469)
- hsa-mir-6760-5p (MIRT500241)
- hsa-mir-4290 (MIRT724824)
- hsa-mir-4469 (MIRT724825)
- hsa-mir-4667-3p (MIRT724826)
- hsa-mir-1470 (MIRT724827)
- hsa-mir-129-2-3p (MIRT724828)
- hsa-mir-129-1-3p (MIRT724829)
- hsa-mir-6779-3p (MIRT724830)
- hsa-mir-4687-5p (MIRT724831)
- hsa-mir-4422 (MIRT724832)
- hsa-mir-6835-3p (MIRT724833)
miRNA Products
- Search ViGene Biosciences for HOXB8
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB8
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-
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HOXB8
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXB8 gene
-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB8 Gene
Localization for HOXB8 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXB8 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for HOXB8 Gene
No Data Available
Interacting Proteins for HOXB8 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007625 | grooming behavior | IEA | -- |
| GO:0008344 | adult locomotory behavior | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXB8 Gene
Transcripts for HOXB8 Gene
mRNA/cDNA for HOXB8 Gene
- (3) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (52) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXB8
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB8
- GenScript: Design CRISPR guide RNA sequences for HOXB8
miRNA Products
- Search ViGene Biosciences for HOXB8
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB8
- Browse OriGene Inhibitory RNA Products For HOXB8
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB8 gene
Clone Products
-
OriGene ORF clones in human for HOXB8
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Flow Cytometry Products
Expression for HOXB8 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Zone Of Polarizing Activity Cells Limb Bud
- Limb Bud Mesenchyme Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Autopod
-
Mesoderm (Gastrulation Derivatives)
- Zone Of Polarizing Activity Cells Limb Bud
- Limb Bud Mesenchyme Cells Limb Bud
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
- Neural Tube (Nervous System)
- NULL (Uncategorized)
-
Colon (Gastrointestinal Tract)
-
Spinal Cord (Nervous System)
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for HOXB8 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x24.4), Kidney - Cortex (x8.2), and Cervix - Endocervix (x4.8).
This gene is overexpressed in Colon muscle (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB8 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXB8 Gene:
HOXB8SOURCE GeneReport for Unigene cluster for HOXB8 Gene:
Hs.514292Evidence on tissue expression from TISSUES for HOXB8 Gene
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for HOXB8
-
OriGene qPCR primer pairs and template standards for HOXB8
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB8 Gene
Orthologs for HOXB8 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | HOXB8 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | LOC100337349 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxb8 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxb8 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXB8 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXB8 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXB8 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxb8 34 |
|
||
| Str.10287 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | hoxb8a 34 35 |
|
||
| hoxb8b 35 |
|
OneToMany | |||
| -- 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Ubx 35 |
|
ManyToMany | |
| abd-A 35 |
|
ManyToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | mab-5 35 |
|
ManyToMany | |
| lin-39 35 |
|
ManyToMany |
- Species where no ortholog for HOXB8 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for HOXB8 Gene
Paralogs for HOXB8 Gene
(20) SIMAP similar genes for HOXB8 Gene using alignment to 4 proteins:
Variants for HOXB8 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000062421 | -- | 48,620,539(+) | CCTCA(C/G)ACCAA | utr-variant-5-prime | |
| rs1000072656 | -- | 48,612,023(+) | GGAGG(C/T)GGCGG | downstream-variant-500B, upstream-variant-2KB | |
| rs1000123927 | -- | 48,621,676(+) | AGAAG(C/T)CGACG | utr-variant-3-prime, utr-variant-5-prime | |
| rs1000367738 | -- | 48,617,958(+) | CAGAG(A/C)TCCTG | utr-variant-5-prime | |
| rs1000541350 | -- | 48,620,758(+) | GACAT(C/T)CTCAG | downstream-variant-500B, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv369n27 | CNV | loss | 19166990 |
| dgv5676n54 | CNV | loss | 21841781 |
| esv2676919 | CNV | deletion | 23128226 |
| esv2758694 | CNV | gain | 17122850 |
| nsv833469 | CNV | loss | 17160897 |
| nsv833471 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
43.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.55;
55.88% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXB8 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXB8
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB8 Gene
Disorders for HOXB8 Gene
Relevant External Links for HOXB8
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HOXB8
No disorders were found for HOXB8 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB8 Gene
Publications for HOXB8 Gene
- Complete mutation analysis panel of the 39 human HOX genes. (PMID: 11857506) Kosaki K. … Matsuo N. (Teratology 2002) 3 4 64
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
- Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3 64
- Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PMID: 2570724) Giampaolo A. … Peschle C. (Differentiation 1989) 3 4 64
- Organization of human class I homeobox genes. (PMID: 2576652) Boncinelli E. … Simeone A. (Genome 1989) 3 4 64
Products for HOXB8 Gene
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- Novus Biologicals Antibodies for HOXB8
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- antibodies-online Antibodies for HOXB8: See all 63
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- GeneTex HOXB8 antibody for HOXB8
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXB8 gene
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- VectorBuilder custom plasmid, inducible vectors for HOXB8
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXB8 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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