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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB8 Gene

protein-coding   GIFtS: 51
GCID: GC17M046688

Homeobox B8

(Previous name: homeo box B8)
(Previous symbols: HOX2, HOX2D)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homeobox B81 2     Homeobox Protein Hox-2D2 3
HOX2D1 2 3 5     Hox-2.42
HOX21 2     Homeo Box 2D2
Homeo Box B81 2     Homeobox Protein Hox-B82
Homeobox Protein Hox-2.42 3     

External Ids:    HGNC: 51191   Entrez Gene: 32182   Ensembl: ENSG000001200687   OMIM: 1429635   UniProtKB: P174813   

Export aliases for HOXB8 gene to outside databases

Previous GC identifers: GC17M046401 GC17M049170 GC17M047030 GC17M047164 GC17M044044 GC17M042058


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXB8 Gene:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding
domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions
as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is
associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an
excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the
obsessive-compulsive spectrum disorder trichotillomania. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB8 Gene: 
HOXB8 (homeobox B8) is a protein-coding gene. Diseases associated with HOXB8 include trichotillomania, and colorectal cancer. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXB8_HUMAN, P17481
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB8 gene promoter:
         E2F-3a   E2F-4   N-Myc   E2F-5   E2F   AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB8 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046688:  view genomic region     (about GC identifiers)

Start:
46,688,739 bp from pter      End:
46,692,478 bp from pter
Size:
3,740 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXB8_HUMAN, P17481 (See protein sequence)
Recommended Name: Homeobox protein Hox-B8  
Size: 243 amino acids; 27574 Da
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: Q9H1I2

Explore the universe of human proteins at neXtProt for HOXB8: NX_P17481

Explore proteomics data for HOXB8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17481

  • HOXB8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXB8 Protein Expression
    REFSEQ proteins: NP_076921.1  
    ENSEMBL proteins: 
     ENSP00000460254   ENSP00000239144   ENSP00000460659   ENSP00000459303  

    Human Recombinant Protein Products for HOXB8: 
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    OriGene Protein Over-expression Lysate for HOXB8
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    Novus Biologicals HOXB8 Protein
    Novus Biologicals HOXB8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXB8 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    HOXB8 for ontologies           About GeneDecksing



    HOXB8 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for HOXB8 
    Cloud-Clone Corp. CLIAs for HOXB8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P17481

    ProtoNet protein and cluster: P17481

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXB8_HUMAN, P17481
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXB8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB8_HUMAN, P17481
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB8:
    homeo box B8(2D),homologous to mouse Hox-2.4,Drosophila Antp,Ubx,abd-A,involved in the establishment of
    anteroposterior polarity of the anterior mouse limb,controlled by SHH through a negative feedback loop

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0043565sequence-specific DNA binding ----
         
    HOXB8 for ontologies           About GeneDecksing


    Phenotypes:
         10 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Hoxb8):
     behavior/neurological  craniofacial  growth/size  hematopoietic system  immune system 
     integument  mortality/aging  nervous system  no phenotypic analysis  skeleton 

    HOXB8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXB8: Hoxb8tm1Mrc Hoxb8tm1.1Mrc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXB8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXB8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXB8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXB8 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXB8:
    hsa-mir-196b (MIRT001042), hsa-mir-196a (MIRT002266)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB8
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB8 (see all 68):
    hsa-miR-548j hsa-miR-128 hsa-miR-30d hsa-miR-342-3p hsa-miR-3916 hsa-miR-30a hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidHOXB8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXB8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB8

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of HOXB8

    Clone
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    GenScript: all cDNA clones in your preferred vector: HOXB8 (NM_024016)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB8
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                         Customized lentivirus expression plasmids for stable overexpression of HOXB8 

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    Search LifeMap BioReagents cell lines for HOXB8
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB8

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/21 Interacting proteins for HOXB8 (P174813 ENSP000002391444) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PBX2P404253, ENSP000003641904I2D: score=1 STRING: ENSP00000364190
    ENSG00000206315P404253I2D: score=1 
    ENSG00000224952P404253I2D: score=1 
    ENSG00000225987P404253I2D: score=1 
    ENSG00000232005P404253I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS--
    GO:0007625grooming behavior IEA--
    GO:0008344adult locomotory behavior IEA--

    HOXB8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB8 (HXB8)

    Search CenterWatch for drugs/clinical trials and news about HOXB8 / HXB8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXB8 gene: 
    NM_024016.3  

    Unigene Cluster for HOXB8:

    Homeobox B8
    Hs.514292  [show with all ESTs]
    Unigene Representative Sequence: NM_024016
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498634 ENST00000239144(uc002inw.3) ENST00000576562 ENST00000468443

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB8
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB8 (see all 68):
    hsa-miR-548j hsa-miR-128 hsa-miR-30d hsa-miR-342-3p hsa-miR-3916 hsa-miR-30a hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidHOXB8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXB8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB8
    Clone
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    OriGene clones in human, mouse for HOXB8 (see all 6)
    OriGene ORF clones in mouse, rat for HOXB8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXB8 (NM_024016)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB8
    Sirion Biotech Customized lentivirus for stable overexpression of HOXB8 
                         Customized lentivirus expression plasmids for stable overexpression of HOXB8 
    Primer
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    OriGene qPCR primer pairs and template standards for HOXB8
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXB8
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB8

    Additional mRNA sequence: AK096222.1 

    3 DOTS entries:

    DT.311092  DT.120924142  DT.92047888 

    24/52 AceView cDNA sequences (see all 52):

    AI492162 AI453041 AI863671 AI309226 AW517327 BF739920 AI080631 AW612644 
    AI522206 BF003064 AI394014 AI672407 NM_024016 BF591180 AW611532 AI278517 
    AW029487 AW376342 BF001845 AI277015 BF054958 BF940412 AI343361 AI262396 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB8 expression in normal human tissues (normalized intensities)      HOXB8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HOXB8 Expression
    About this image


    HOXB8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Umbilical Artery Endothelial Cells (HUAEC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem progenitor SK17
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Autopod
             Human Annulus Fibrosus Cells (HAFC)   
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Prechondrocytic Mesenchymal Cells Autopod
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Brain Pericytes   
             brain/hindbrain   

    See HOXB8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB8

    SOURCE GeneReport for Unigene cluster: Hs.514292
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXB8: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXB8 gene from 6/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxb81 , 5 homeobox B81, 5 95.2(n)1
    98.35(a)1
      11 (59.82 cM)5
    154161  NM_010461.21  NP_034591.11 
     962819055 
    chicken
    (Gallus gallus)
    Aves HOXB81 homeobox B8 83.82(n)
    91.7(a)
      395737  NM_204911.1  NP_990242.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXB86
    Uncharacterized protein
    87(a)
    1 ↔ 1
    6(75623536-75629522)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX849744.12   -- 86.69(n)    BX849744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC053287.12   -- 81.03(n)   337442  BC053287.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubx6
    abd-A6
    abdominal A
    20(a)
    12(a)
    many ↔ many
    many ↔ many
    3R(12482345-12560348)
    3R(12632936-12655767)


    ENSEMBL Gene Tree for HOXB8 (if available)
    TreeFam Gene Tree for HOXB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB8 gene
    GSX12  HOXA72  HOXA12  HOXB32  HOXD12  HOXA22  HOXB52  HOXC62  
    HOXC52  GSX22  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  
    HOXA32  HOXD82  HOXB62  HOXB12  HOXB22  HOXD42  PDX12  HOXB72  
    HOXC42  
    18/21 SIMAP similar genes for HOXB8 using alignment to 4 protein entries:     HXB8_HUMAN (see all proteins) (see all similar genes):
    HOX B6    HOXA4    HOXC8    HOXC13    MNX1    CDX1
    HOXD8    HOXD11    HOXA-9    NKX2-5    HOXB7    NKX6-1
    HOXA7    HOXB6    HHEX    HOXB1    CDX2    HLX

    HOXB8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/87 SNPs in HOXB8 are shown (see all 87)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012275891,2
    --46690086(+) AGCGA-/GCGAGAG 1 -- ut310--------
    rs560522471,2
    C,F--46690458(+) CTGGCC/ACCGCT 1 -- ut311Minor allele frequency- A:0.17WA 118
    rs1120464021,2
    C,F--46690623(+) CTCCAG/CCTTCT 2 /L /V mis14Minor allele frequency- C:0.02CSA WA NA EU 5903
    rs1997141421,2
    --46690660(+) TTGCTA/GCTGGG 2 S syn10--------
    rs1395153891,2
    F--46690765(+) ACCTCG/TATTCG 2 I syn11Minor allele frequency- T:0.00NA 4552
    rs454414921,2
    C,F--46690777(+) CGCTTA/GCGAGT 2 R syn16Minor allele frequency- G:0.08WA CSA NA EU 6117
    rs1509770431,2
    C,F--46690822(+) TCCAGG/TGTCTG 2 T syn11Minor allele frequency- T:0.00NA 4538
    rs1435750641,2
    --46690974(+) CCATTA/GTAATA 1 -- int10--------
    rs3758744021,2
    C--46691011(+) GGGGG-/GGGGGG 1 -- int10--------
    rs1902624321,2
    C--46691039(+) GGTCGA/GCGGAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for HOXB8 (46688739 - 46692478 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HOXB8:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676919CNV Deletion23128226
    dgv3223n71CNV Loss21882294
    dgv369n27CNV Loss19166990
    dgv3224n71CNV Loss21882294
    nsv833469CNV Loss17160897
    dgv3222n71CNV Loss21882294
    nsv833471CNV Gain17160897
    dgv988e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142963    OMIM disorders: --

    3 diseases for HOXB8:    About MalaCards
    trichotillomania    colorectal cancer    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for HOXB8:
    Trichotillomania

    HOXB8 for disorders           About GeneDecksing


    Export disorders for HOXB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB8 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with HOXB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    2. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    3. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    4. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
    5. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    6. HOXB8 expression in ovarian serous carcinoma effusions is associated with shorter survival. (PubMed id 23438671)1 Stavnes H.T....Davidson B. (2013)
    7. Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. (PubMed id 15617687)1 Williams T.M....Innis J.W. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. Hoxb8 is required for normal grooming behavior in mice. (PubMed id 11779477)1 Greer J.M. and Capecchi M.R. (2002)
    10. HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. (PubMed id 11571641)1 Knoepfler P.S....Kamps M.P. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3218 HGNC: 5119 AceView: HOXB8 Ensembl:ENSG00000120068 euGenes: HUgn3218
    ECgene: HOXB8 H-InvDB: HOXB8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXB8 gene:
    Search GeneIP for patents involving HOXB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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