Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB8 Gene

protein-coding   GIFtS: 51
GCID: GC17M046688

homeobox B8

(Previous name: homeo box B8 )
(Previous symbols: HOX2, HOX2D)
 Explore 4 diseases affiliated with
HOXB8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXB8    

Aliases
for HOXB8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox B81 2     Homeobox Protein Hox-2D2 3
HOX2D1 2 3 5     Hox-2.42
HOX21 2     Homeo Box 2D2
Homeo Box B81 2     Homeobox Protein Hox-B82
Homeobox Protein Hox-2.42 3     

External Ids:    HGNC: 51191   Entrez Gene: 32182   Ensembl: ENSG000001200687   OMIM: 1429635   UniProtKB: P174813   

Export aliases for HOXB8 gene to outside databases

Previous GC identifers: GC17M046401 GC17M049170 GC17M047030 GC17M047164 GC17M044044 GC17M042058


Summaries
for HOXB8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXB8:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It
is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a
sequence-specific transcription factor that is involved in development. Increased expression of this gene is
associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an
excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the
obsessive-compulsive spectrum disorder trichotillomania. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXB8_HUMAN, P17481
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB8


Genomic Views
for HOXB8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB8 gene promoter:
         E2F-3a   E2F-4   N-Myc   E2F-5   E2F   AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXB8 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB8 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046688:  view genomic region     (about GC identifiers)

Start:
 46,688,739 bp from pter      End:
 46,692,478 bp from pter
Size:
 3,740 bases      Orientation:
 minus strand

Proteins
for HOXB8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXB8_HUMAN, P17481 (See protein sequence)
Recommended Name: Homeobox protein Hox-B8  
Size: 243 amino acids; 27574 Da
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: Q9H1I2

Explore the universe of human proteins at neXtProt for HOXB8: NX_P17481

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17481

    • HOXB8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_076921.1  
    ENSEMBL proteins: 
     ENSP00000460254   ENSP00000239144   ENSP00000460659   ENSP00000459303  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: HOXB8
    OriGene Custom Protein Services for HOXB8 
    GenScript Custom Purified and Recombinant Proteins Services for HOXB8
    Novus Biologicals HOXB8 Protein
    Novus Biologicals HOXB8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXB8

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    HOXB8 for ontologies           About GeneDecksing



    HOXB8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HOXB8 
    GenScript Custom Superior Antibodies Services for HOXB8
    Novus Biologicals HOXB8 Antibodies
    Search for Antibodies for HOXB8 at Abcam  
    Uscn Antibodies for HOXB8
    ThermoFisher Antibodies for HOXB8

    Assay Products for HOXB8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXB8
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HOXB8

    Protein Domains /
    Families
    for HOXB8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXB8 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P17481

    ProtoNet protein and cluster: P17481

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXB8_HUMAN, P17481
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXB8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXB8_HUMAN, P17481
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB8:
    homeo box B8(2D),homologous to mouse Hox-2.4,Drosophila Antp,Ubx,abd-A,involved in the establishment of anteroposterior
    polarity of the anterior mouse limb,controlled by SHH through a negative feedback loop

    miRNA
    Products:            		miRTarBase miRNAs that target HOXB8:
    hsa-mir-196b (MIRT001042), hsa-mir-196a (MIRT002266)

    Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB8
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB8 (see all 68):
    hsa-miR-548j hsa-miR-128 hsa-miR-30d hsa-miR-342-3p hsa-miR-3916 hsa-miR-30a hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB8 (see all 4)
    OriGene shRNA RFP: HOXB8
    OriGene siRNA: HOXB8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXB8

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXB8 (NM_024016)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB8 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HOXB8
    Search LifeMap BioReagents cell lines for HOXB8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB8

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--


    HOXB8 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for HOXB8: Hoxb8tm1Mrc Hoxb8tm1.1Mrc
         10 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Hoxb8):
     behavior/neurological  craniofacial  growth/size  hematopoietic system  immune system 
     integument  mortality/aging  nervous system  no phenotypic analysis  skeleton 

    HOXB8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXB8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB8

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/15 Interacting proteins for HOXB8 (P174813 ENSP000002391444) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
    PBX2P404253, ENSP000003641904I2D: score=1 STRING: ENSP00000364190
    PBX1P404243, ENSP000004058904I2D: score=3 STRING: ENSP00000405890
    PBX3P404263, ENSP000003625884I2D: score=3 STRING: ENSP00000362588
    ASB1Q9Y5763I2D: score=1 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS--
    GO:0007625grooming behavior IEA--
    GO:0008344adult locomotory behavior IEA--


    HOXB8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXB8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB8
    Search CenterWatch for drugs/clinical trials and news about HOXB8 / HXB8 

    Transcripts
    for HOXB8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXB8 gene: 
    NM_024016.3  

    Unigene Cluster for HOXB8:

    Homeobox B8
    Hs.514292  [show with all ESTs]
    Unigene Representative Sequence: NM_024016
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498634 ENST00000239144(uc002inw.3) ENST00000576562 ENST00000468443


    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB8
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB8 (see all 68):
    hsa-miR-548j hsa-miR-128 hsa-miR-30d hsa-miR-342-3p hsa-miR-3916 hsa-miR-30a hsa-miR-548a-5p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB8 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB8 (see all 4)
    OriGene shRNA RFP: HOXB8
    OriGene siRNA: HOXB8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB8
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB8 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB8
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXB8 (NM_024016)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB8 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB8

    Additional cDNA sequence: AK096222.1 

    3 DOTS entries:

    DT.311092  DT.120924142  DT.92047888 

    24/52 AceView cDNA sequences (see all 52):

    AI309226 AI453041 AI863671 NM_024016 BF003064 AI394014 AI492162 AI080631 
    BF739920 AI672407 AI522206 AW517327 AW612644 AI343361 AW134603 AI262396 
    AW611532 BE856784 BF591180 AI278517 AI337393 AA447928 AI291375 AI918020 

    GeneLoc Exon Structure


    Expression
    for HOXB8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXB8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbAutopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LimbLimb BudZone Of Polarizing Activity CellsMesoderm
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
    Mesendoderm (Derivation and sorti...)

    See HOXB8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB8

    SOURCE GeneReport for Unigene cluster: Hs.514292
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXB8: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB8
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB8
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB8

    Orthologs
    for HOXB8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXB8 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXB81 homeobox B8 83.82(n)
    91.7(a)    		   395737  NM_204911.1  NP_990242.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXB86
    		 --
    		 87(a)
    		 1 ↔ 1
    		 6(75626178-75629516)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BX849744.12   -- 86.69(n)    BX849744.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC053287.12   -- 81.03(n)   337442  BC053287.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta zen26
    Ubx6
    (see all 4)    		 Ultrabithorax
    (see all 4)    		 17(a)
    16(a)
    (see all 4)    		 possible ortholog
    many ↔ many
    (see all 4)    		 3R(2568854-2569862)
    3R(12482345-12560348)
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-396
    egl-56
    		 Homeobox protein egl-5
    		 20(a)
    20(a)
    		 possible ortholog
    1 ↔ many
    		 III(7528603-7536567)
    III(7814317-7816386)


    ENSEMBL Gene Tree for HOXB8 (if available)
    TreeFam Gene Tree for HOXB8 (if available) 

    Paralogs
    for HOXB8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB8 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXB42  HOXA52  HOXA42  HOXD32  HOXC82  HOXA62  
    HOXA32  HOXD82  HOXB12  HOXB62  HOXD42  HOXB22  HOXB72  PDX12  
    HOXC42  
    18/22 SIMAP similar genes for HOXB8 using alignment to 4 protein entries:     HXB8_HUMAN (see all proteins) (see all similar genes):
    HOX B6    HOXA4    HOXC8    HOXC13    MNX1    CDX1
    MEOX1    HOXD8    HOXD11    HOXA-9    NKX2-5    HOXB7
    NKX6-1    HOXA7    HOXB6    HHEX    HOXB1    CDX2

    HOXB8 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXB8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/63 NCBI SNPs in HOXB8 are shown (see all 63)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs560522471,2
    		F,--46690458(+) CTGGCC/ACCGCT 1 -- ut311Minor allele frequency- A:0.17WA 118
    rs1120464021,2
    		C,F,--46690623(+) CTCCAG/CCTTCT 2 /L /V mis14Minor allele frequency- C:0.02CSA WA NA EU 5903
    rs1997141421,2
    		--46690660(+) TTGCTA/GCTGGG 2 S syn10--------
    rs1395153891,2
    		F--46690765(+) ACCTCG/TATTCG 2 I syn11Minor allele frequency- T:0.00NA 4552
    rs454414921,2
    		C,F,--46690777(+) CGCTTA/GCGAGT 2 R syn16Minor allele frequency- G:0.08WA CSA NA EU 6117
    rs1509770431,2
    		C,F,--46690822(+) TCCAGG/TGTCTG 2 T syn11Minor allele frequency- T:0.00NA 4538
    rs1435750641,2
    		--46690974(+) CCATTA/GTAATA 1 -- int10--------
    rs1902624321,2
    		--46691039(+) GGTCGA/GCGGAG 1 -- int10--------
    rs562929721,2
    		C,--46691043(+) GGCGGC/AGGAGG 1 -- int16Minor allele frequency- A:0.09WA NA CSA 128
    rs74063551,2
    		C,F,H,--46691423(+) GCAGGG/ATGAGG 1 -- int123Minor allele frequency- A:0.32NS EA NA WA CSA 2346

    HapMap Linkage Disequilibrium report for HOXB8 (46688739 - 46692478 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HOXB8
         2 CNVs: 53230 4040

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB8
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXB8

    Disorders / Diseases
    for HOXB8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXB8 for disorders           About GeneDecksing

    OMIM gene information: 142963    OMIM disorders: --

    4 diseases for HOXB8:    About MalaCards
    trichotillomania    colorectal cancer    neuroblastoma    neuronitis

    1 disease from the University of Copenhagen DISEASES database for HOXB8:
    Trichotillomania

    Export disorders for HOXB8 gene to outside databases

    Publications
    for HOXB8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB8 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with HOXB8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    2. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    3. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    4. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
    5. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    6. Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. (PubMed id 15617687)1 Williams T.M....Innis J.W. (2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Hoxb8 is required for normal grooming behavior in mice. (PubMed id 11779477)1 Greer J.M. and Capecchi M.R. (2002)
    9. HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. (PubMed id 11571641)1 Knoepfler P.S....Kamps M.P. (2001)
    10. Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. (PubMed id 11438208)1 Fujino T....Nakamura T. (2001)

    External Searches for HOXB8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXB8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3218 HGNC: 5119 AceView: HOXB8 Ensembl:ENSG00000120068 euGenes: HUgn3218
    ECgene: HOXB8 H-InvDB: HOXB8

    Other Databases showing HOXB8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXB8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB8 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXB8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXB8 gene:
    Search GeneIP for patents involving HOXB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HOXB8 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HOXB8  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB8   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB8  
     OriGene Protein Over-expression Lysate for HOXB8   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HOXB8   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB8   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB8  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXB8   OriGene Custom Protein Services for HOXB8  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HOXB8
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB8
     GenScript Custom Purified and Recombinant Proteins Services for HOXB8 GenScript cDNA clones with any tag delivered in your preferred vector for HOXB8
     GenScript Custom Assay Services for HOXB8 GenScript Custom Superior Antibodies Services for HOXB8
     GenScript Custom overexpressing Cell Line Services for HOXB8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXB8 promoter
     Search Chromatin IP Primers for HOXB8
     RT2 qPCR Primer Assay in human, mouse, rat HOXB8
     GNC Network for HOXB8
     SABiosciences PCR Arrays including human, mouse, rat HOXB8
     Search Tocris compounds for HOXB8
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HOXB8 antibodies
     HOXB8 proteins
     HOXB8 lysates
     Search for Antibodies for HOXB8 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for HOXB8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HOXB8 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HOXB8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB8
     SwitchGear 3'UTR luciferase reporter plasmids for HOXB8
     SwitchGear Promoter luciferase reporter plasmids for HOXB8
     ThermoFisher Antibodies for HOXB8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB8
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HOXB8 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4