Aliases for HOXB7 Gene
Aliases for HOXB7 Gene
External Ids for HOXB7 Gene
- HGNC: 5118
- Entrez Gene: 3217
- Ensembl: ENSG00000260027
- OMIM: 142962
- UniProtKB: P09629
Previous HGNC Symbols for HOXB7 Gene
- HOX2
- HOX2C
Previous GeneCards Identifiers for HOXB7 Gene
- GC17M046395
- GC17M049165
- GC17M047026
- GC17M047159
- GC17M044039
- GC17M046684
- GC17M042053
Summaries for HOXB7 Gene
-
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB7 Gene
HOXB7 (Homeobox B7) is a Protein Coding gene. Diseases associated with HOXB7 include Ovarian Endodermal Sinus Tumor and Ovarian Primitive Germ Cell Tumor. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.
UniProtKB/Swiss-Prot for HOXB7 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB7 Gene
Genomics for HOXB7 Gene
Regulatory Elements for HOXB7 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G048538 | 2.3 | VISTA FANTOM5 Ensembl ENCODE dbSUPER | 4.4 | +60.4 | 60407 | 68.8 | CREB3L1 AGO1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ZNF610 | HOXB2 SKAP1 HOXB9 HOXB3 ENSG00000264701 HOXB-AS1 HOXB-AS3 SUMO2P17 HOXB-AS4 HOXB1 |
| GH17G048623 | 1.7 | FANTOM5 ENCODE dbSUPER | 2.2 | +6.9 | 6922 | 6.4 | HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A FEZF1 ZNF766 CBX5 SP3 | ENSG00000264701 HOXB9 PRAC2 PRAC1 HOXB13 LOC105371811 HOXB2 HOXB8 HOXB5 HOXB6 |
| GH17G048636 | 1.2 | ENCODE dbSUPER | 0.7 | -3.1 | -3102 | 0.2 | ATF1 PKNOX1 CREB3L1 ARID4B ZNF48 ZNF766 ZNF143 REST MIER2 ZNF592 | HOXB7 LINC02086 |
| GH17G048634 | 0.7 | dbSUPER | 0.7 | -1.2 | -1195 | 0.8 | BCOR SUZ12 TRIM24 EZH2 L3MBTL2 RNF2 CBX2 CEBPB ATF2 ZBTB7A | HOXB2 HOXB7 LINC02086 |
| GH17G048640 | 0.6 | dbSUPER | 0.4 | -6.7 | -6688 | 1.2 | RNF2 SUZ12 CBX2 FEZF1 MNT CBX8 NFIC ZSCAN5C PRDM10 EZH2 | HOXB2 CDK5RAP3 LINC02086 HOXB7 |
- Transcription factor binding sites by QIAGEN in the HOXB7 gene promoter:
Regulatory Element Products
Genomic Location for HOXB7 Gene
- Chromosome:
- 17
- Start:
- 48,607,227 bp from pter
- End:
- 48,633,572 bp from pter
- Size:
- 26,346 bases
- Orientation:
- Minus strand
Genomic View for HOXB7 Gene
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXB7 Gene
Proteins for HOXB7 Gene
-
Protein details for HOXB7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09629-HXB7_HUMAN
- Recommended name:
- Homeobox protein Hox-B7
- Protein Accession:
- P09629
- A8K3N8
- Q15957
- Q53FN3
- Q96BQ6
Protein attributes for HOXB7 Gene
- Size:
- 217 amino acids
- Molecular mass:
- 24015 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXB7 Gene
Post-translational modifications for HOXB7 Gene
Other Protein References for HOXB7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HOXB7
- R&D Systems Antibodies for HOXB7 (HOXB7)
-
Custom Antibody ServicesOriGene Antibodies for HOXB7
- Novus Biologicals Antibodies for HOXB7
- Invitrogen Antibodies for HOXB7
- antibodies-online Antibodies for HOXB7: See all 101
- Search GeneTex for Antibodies for HOXB7
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXB7
Protein Products
-
OriGene Purified Proteins for HOXB7
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXB7
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- antibodies-online Proteins for HOXB7: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXB7
Assay Products
No data available for DME Specific Peptides for HOXB7 Gene
Domains & Families for HOXB7 Gene
Gene Families for HOXB7 Gene
Protein Domains for HOXB7 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXB7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P09629- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXB7 Gene
Molecular function for HOXB7 Gene
- GENATLAS Biochemistry:
- homeo box B7(2C),homologous to mouse Hox-2.3,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 8756643 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IDA | 8756643 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | NAS | 1678287 |
| GO:0005515 | protein binding | IPI | 17308091 |
Phenotypes for HOXB7 Gene
- MGI mutant phenotypes for HOXB7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXB7:
Animal Models for HOXB7 Gene
- MGI Knock Outs for HOXB7:
-
- Hoxb7 tm1Mrc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB7 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB7 gene
- Search ViGene Biosciences for HOXB7
CRISPR Products
-
OriGene CRISPR knockouts for HOXB7
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB7
- GenScript: Design CRISPR guide RNA sequences for HOXB7
miRNA for HOXB7 Gene
- miRTarBase miRNAs that target HOXB7
miRNA Products
- Search ViGene Biosciences for HOXB7
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB7
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-
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HOXB7
-
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-
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-
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Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12425) for HOXB7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB7 Gene
Localization for HOXB7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXB7 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | NAS | 1678287 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for HOXB7 Gene
Interacting Proteins for HOXB7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 1678287 |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007275 | multicellular organism development | NAS | 2885844 |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXB7 Gene
Transcripts for HOXB7 Gene
mRNA/cDNA for HOXB7 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (95) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXB7
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB7
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miRNA Products
- Search ViGene Biosciences for HOXB7
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB7
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB7 gene
Clone Products
-
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Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-12425) for HOXB7
Expression for HOXB7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Kidney (Urinary System)
- Endothelium (Cardiovascular System)
- Gut Tube (Gastrointestinal Tract)
- Motor Neurons (Nervous System)
- Neurons
- Spinal Cord (Nervous System)
- NULL (Uncategorized)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for HOXB7 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXB7 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXB7 Gene:
HOXB7SOURCE GeneReport for Unigene cluster for HOXB7 Gene:
Hs.436181Evidence on tissue expression from TISSUES for HOXB7 Gene
- Liver(4)
- Stomach(4)
- Kidney(2.5)
Primer Products
-
OriGene qPCR primer pairs for HOXB7
-
OriGene qPCR primer pairs and template standards for HOXB7
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB7 Gene
Orthologs for HOXB7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXB7 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXB7 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXB7 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxb7 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxb7 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXB7 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXB7 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXB7 34 |
|
||
| HOXB-7 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | HOXB7 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100494663 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.1210 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxb7a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Antp 36 35 |
|
- Species where no ortholog for HOXB7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXB7 Gene
Paralogs for HOXB7 Gene
(18) SIMAP similar genes for HOXB7 Gene using alignment to 3 proteins:
Variants for HOXB7 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000072656 | -- | 48,612,023(+) | GGAGG(C/T)GGCGG | downstream-variant-500B, upstream-variant-2KB | |
| rs1001064397 | -- | 48,607,310(+) | GGACG(A/G)GAAGC | utr-variant-3-prime | |
| rs1001448322 | -- | 48,609,940(+) | GTCCT(G/T)TTCTC | intron-variant | |
| rs1001957463 | -- | 48,612,851(+) | AAAAA(A/G)AGACA | upstream-variant-2KB, utr-variant-3-prime | |
| rs1002494184 | -- | 48,609,900(+) | CTCCC(C/T)CCACC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv369n27 | CNV | loss | 19166990 |
| dgv5676n54 | CNV | loss | 21841781 |
| esv2676919 | CNV | deletion | 23128226 |
| esv2758694 | CNV | gain | 17122850 |
| nsv833469 | CNV | loss | 17160897 |
| nsv833471 | CNV | gain | 17160897 |
Relevant External Links for HOXB7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXB7
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB7 Gene
Disorders for HOXB7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ovarian endodermal sinus tumor |
|
|
| ovarian primitive germ cell tumor |
|
|
Relevant External Links for HOXB7
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB7 Gene
Publications for HOXB7 Gene
- Differential expression of HOXB7 gene in multiple myeloma and extramedullary multiple myeloma patients. (PMID: 19878270) Novak E.M. … Bydlowski S.P. (Eur. J. Haematol. 2010) 3 22 64
- Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. (PMID: 19956843) De Souza Setubal Destro M.F. … Coletta R.D. (Int. J. Oncol. 2010) 3 22 64
- A role for the HOXB7 homeodomain protein in DNA repair. (PMID: 17308091) Rubin E. … Sukumar S. (Cancer Res. 2007) 3 22 64
- Inhibition of 13-cis retinoic acid-induced gene expression of homeobox B7 by thalidomide. (PMID: 17514648) MilanoviA8 D. … Herskind C. (Int. J. Cancer 2007) 3 22 64
- Correlation between genetic variations in Hox clusters and Hirschsprung's disease. (PMID: 17274802) Garcia-BarcelA^ M.M. … Tam P.K. (Ann. Hum. Genet. 2007) 3 46 64
Products for HOXB7 Gene
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- antibodies-online Antibodies for HOXB7: See all 101
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- Yeast expression
Sources for HOXB7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (86) GenomeRNAi
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- (88) miRTarBase
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- (90) Invitrogen
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- (92) Vector BioLabs
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- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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- (104) Addgene
- (105) antibodies-online
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- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




