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Aliases for HOXB7 Gene

Aliases for HOXB7 Gene

  • Homeobox B7 2 3 5
  • Homeobox Protein HHO.C1 3 4
  • Homeobox Protein Hox-2C 3 4
  • Homeo Box B7 2 3
  • HOX2C 3 4
  • Homeobox Protein Hox-B7 3
  • Homeo Box C1 Protein 3
  • Homeo Box 2C 3
  • Hox-2.3 3
  • HHO.C1 3
  • HOX2 3

External Ids for HOXB7 Gene

Previous HGNC Symbols for HOXB7 Gene

  • HOX2
  • HOX2C

Previous GeneCards Identifiers for HOXB7 Gene

  • GC17M046395
  • GC17M049165
  • GC17M047026
  • GC17M047159
  • GC17M044039
  • GC17M046684
  • GC17M042053

Summaries for HOXB7 Gene

Entrez Gene Summary for HOXB7 Gene

  • This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB7 Gene

HOXB7 (Homeobox B7) is a Protein Coding gene. Diseases associated with HOXB7 include Ovarian Endodermal Sinus Tumor and Ovarian Primitive Germ Cell Tumor. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXB7 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB7 Gene

Genomics for HOXB7 Gene

Regulatory Elements for HOXB7 Gene

Enhancers for HOXB7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F048538 2 VISTA FANTOM5 Ensembl ENCODE 4.4 +60.4 60407 68.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 ZNF2 YY1 ZNF143 HOXB2 SKAP1 RN7SL125P GIP LOC105371815 ENSG00000251461 ENSG00000264243 LINC02075 HOXB9 HOXB3
GH17F048623 1.4 FANTOM5 ENCODE 2.2 +6.9 6922 6.4 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 CBX5 SP3 REST MEF2D ENSG00000264701 LRRC46 TBX21 HOXB9 PRAC2 PRAC1 HOXB13 LOC105371811 HOXB2 HOXB8
GH17F048636 1 ENCODE 0.8 -3.1 -3102 0.2 ATF1 PKNOX1 ARID4B ZNF48 ZNF143 MIER2 REST CBX8 SMARCA4 MXD3 LRRC46 HOXB7 LINC02086
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOXB7 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXB7 Gene

Chromosome:
17
Start:
48,607,227 bp from pter
End:
48,633,572 bp from pter
Size:
26,346 bases
Orientation:
Minus strand

Genomic View for HOXB7 Gene

Genes around HOXB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB7 Gene

Proteins for HOXB7 Gene

  • Protein details for HOXB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09629-HXB7_HUMAN
    Recommended name:
    Homeobox protein Hox-B7
    Protein Accession:
    P09629
    Secondary Accessions:
    • A8K3N8
    • Q15957
    • Q53FN3
    • Q96BQ6

    Protein attributes for HOXB7 Gene

    Size:
    217 amino acids
    Molecular mass:
    24015 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB7 Gene

Post-translational modifications for HOXB7 Gene

  • Ubiquitination at Lys 191 and Lys 193
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXB7 Gene

Domains & Families for HOXB7 Gene

Gene Families for HOXB7 Gene

Suggested Antigen Peptide Sequences for HOXB7 Gene

Graphical View of Domain Structure for InterPro Entry

P09629

UniProtKB/Swiss-Prot:

HXB7_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB7: view

Function for HOXB7 Gene

Molecular function for HOXB7 Gene

GENATLAS Biochemistry:
homeo box B7(2C),homologous to mouse Hox-2.3,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,NAS 1678287
GO:0005515 protein binding IPI 17308091
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB7: view
genes like me logo Genes that share phenotypes with HOXB7: view

Animal Models for HOXB7 Gene

MGI Knock Outs for HOXB7:

Animal Model Products

miRNA for HOXB7 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXB7

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB7 Gene

Localization for HOXB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXB7 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 1678287
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOXB7: view

Pathways & Interactions for HOXB7 Gene

SuperPathways for HOXB7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1678287
GO:0007275 multicellular organism development NAS 2885844
GO:0009952 anterior/posterior pattern specification IEA --
GO:0030099 myeloid cell differentiation IEA --
genes like me logo Genes that share ontologies with HOXB7: view

No data available for Pathways by source and SIGNOR curated interactions for HOXB7 Gene

Drugs & Compounds for HOXB7 Gene

(1) Additional Compounds for HOXB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HOXB7: view

Transcripts for HOXB7 Gene

mRNA/cDNA for HOXB7 Gene

Unigene Clusters for HOXB7 Gene

Homeobox B7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXB7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB7 Gene

No ASD Table

Relevant External Links for HOXB7 Gene

GeneLoc Exon Structure for
HOXB7
ECgene alternative splicing isoforms for
HOXB7

Expression for HOXB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXB7 Gene

mRNA differential expression in normal tissues according to GTEx for HOXB7 Gene

This gene is overexpressed in Colon - Transverse (x10.4), Kidney - Cortex (x5.1), and Small Intestine - Terminal Ileum (x4.8).

Protein differential expression in normal tissues from HIPED for HOXB7 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXB7 Gene



Protein tissue co-expression partners for HOXB7 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOXB7 Gene:

HOXB7

SOURCE GeneReport for Unigene cluster for HOXB7 Gene:

Hs.436181
genes like me logo Genes that share expression patterns with HOXB7: view

No data available for mRNA Expression by UniProt/SwissProt for HOXB7 Gene

Orthologs for HOXB7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB7 34 35
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia HOXB7 34 35
  • 96.47 (n)
dog
(Canis familiaris)
Mammalia HOXB7 34 35
  • 95.69 (n)
mouse
(Mus musculus)
Mammalia Hoxb7 34 16 35
  • 93.59 (n)
rat
(Rattus norvegicus)
Mammalia Hoxb7 34
  • 92.79 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXB7 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB7 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB7 34
  • 76.65 (n)
HOXB-7 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXB7 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494663 34
  • 74.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1210 34
zebrafish
(Danio rerio)
Actinopterygii hoxb7a 34 35
  • 65.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta Antp 36 35
  • 82 (a)
Species where no ortholog for HOXB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB7 Gene

ENSEMBL:
Gene Tree for HOXB7 (if available)
TreeFam:
Gene Tree for HOXB7 (if available)

Paralogs for HOXB7 Gene

(18) SIMAP similar genes for HOXB7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXB7: view

Variants for HOXB7 Gene

Sequence variations from dbSNP and Humsavar for HOXB7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1042216 -- 48,607,979(-) CGCAC(A/G)CGCTC reference, missense
rs1042226 -- 48,607,799(-) GGAGA(C/G)GAAGA utr-variant-3-prime
rs111248214 -- 48,611,497(+) CTCAC(A/G)ACTCT upstream-variant-2KB
rs112769038 -- 48,609,474(+) CCTGA(C/G)CATTG intron-variant
rs113188234 -- 48,608,967(+) AGAAG(C/G)TAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXB7 Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2676919 CNV deletion 23128226
nsv833471 CNV gain 17160897
nsv833469 CNV loss 17160897
esv2758694 CNV gain 17122850

Variation tolerance for HOXB7 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.38; 71.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB7 Gene

Disorders for HOXB7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for HOXB7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian endodermal sinus tumor
  • endodermal sinus tumor of ovary
ovarian primitive germ cell tumor
- elite association - COSMIC cancer census association via MalaCards
Search HOXB7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOXB7

Genetic Association Database (GAD)
HOXB7
Human Genome Epidemiology (HuGE) Navigator
HOXB7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB7
genes like me logo Genes that share disorders with HOXB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB7 Gene

Publications for HOXB7 Gene

  1. Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. (PMID: 19956843) De Souza Setubal Destro M.F. … Coletta R.D. (Int. J. Oncol. 2010) 3 22 64
  2. Differential expression of HOXB7 gene in multiple myeloma and extramedullary multiple myeloma patients. (PMID: 19878270) Novak E.M. … Bydlowski S.P. (Eur. J. Haematol. 2010) 3 22 64
  3. A role for the HOXB7 homeodomain protein in DNA repair. (PMID: 17308091) Rubin E. … Sukumar S. (Cancer Res. 2007) 3 22 64
  4. Inhibition of 13-cis retinoic acid-induced gene expression of homeobox B7 by thalidomide. (PMID: 17514648) MilanoviA8 D. … Herskind C. (Int. J. Cancer 2007) 3 22 64
  5. Correlation between genetic variations in Hox clusters and Hirschsprung's disease. (PMID: 17274802) Garcia-BarcelA^ M.M. … Tam P.K. (Ann. Hum. Genet. 2007) 3 46 64

Products for HOXB7 Gene

Sources for HOXB7 Gene

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