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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB7 Gene

protein-coding   GIFtS: 59
GCID: GC17M046684

Homeobox B7

(Previous name: homeo box B7)
(Previous symbols: HOX2, HOX2C)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homeobox B71 2     HHO.C12
HOX2C1 2 3 5     Hox-2.32
HOX21 2     Homeo Box 2C2
Homeo Box B71 2     Homeo Box C1 Protein2
Homeobox Protein HHO.C12 3     Homeobox Protein Hox-B72
Homeobox Protein Hox-2C2 3     

External Ids:    HGNC: 51181   Entrez Gene: 32172   Ensembl: ENSG000002600277   OMIM: 1429625   UniProtKB: P096293   

Export aliases for HOXB7 gene to outside databases

Previous GC identifers: GC17M046395 GC17M049165 GC17M047026 GC17M047159 GC17M044039 GC17M042053


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXB7 Gene:
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a
sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased
expression of this gene is associated with some cases of melanoma and ovarian carcinoma. (provided by RefSeq, Jul
2008)

GeneCards Summary for HOXB7 Gene: 
HOXB7 (homeobox B7) is a protein-coding gene. Diseases associated with HOXB7 include cytomegalovirus infection, and multiple myeloma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXB7_HUMAN, P09629
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB7 gene promoter:
         AML1a   STAT3   CUTL1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB7 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046684:  view genomic region     (about GC identifiers)

Start:
46,684,594 bp from pter      End:
46,724,385 bp from pter
Size:
39,792 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXB7_HUMAN, P09629 (See protein sequence)
Recommended Name: Homeobox protein Hox-B7  
Size: 217 amino acids; 24015 Da
Subcellular location: Nucleus
Secondary accessions: A8K3N8 Q15957 Q53FN3 Q96BQ6

Explore the universe of human proteins at neXtProt for HOXB7: NX_P09629

Explore proteomics data for HOXB7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09629

  • HOXB7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXB7 Protein Expression
    REFSEQ proteins: NP_004493.3  
    ENSEMBL proteins: 
     ENSP00000239165  

    Human Recombinant Protein Products for HOXB7: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXB7 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS1678287
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    HOXB7 for ontologies           About GeneDecksing



    HOXB7 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for HOXB7 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P09629

    ProtoNet protein and cluster: P09629

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXB7_HUMAN, P09629
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXB7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB7_HUMAN, P09629
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB7:
    homeo box B7(2C),homologous to mouse Hox-2.3,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS1678287
    GO:0005515protein binding IPI17308091
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXB7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXB7:
     Decreased viability with pacli 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hoxb7):
     hematopoietic system  immune system  skeleton 

    HOXB7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hoxb7tm1Mrc for HOXB7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXB7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXB7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXB7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXB7 

    miRNA
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    miRTarBase miRNAs that target HOXB7:
    hsa-mir-196a (MIRT004244)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB7
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB7 (see all 11):
    hsa-miR-4283 hsa-miR-520d-5p hsa-miR-548v hsa-miR-3935 hsa-miR-1236 hsa-miR-337-3p hsa-miR-196a hsa-miR-3927
    SwitchGear 3'UTR luciferase reporter plasmidHOXB7 3' UTR sequence
    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of HOXB7 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/14 Interacting proteins for HOXB7 (P096291, 3 ENSP000002391654) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKDCP785271, 3, ENSP000003134204EBI-1248457,EBI-352053 I2D: score=1 STRING: ENSP00000313420
    XRCC5P130101, 3EBI-1248457,EBI-357997 I2D: score=1 
    HOXB6P175093, ENSP000002256484I2D: score=1 STRING: ENSP00000225648
    XRCC6P129563, ENSP000003522574I2D: score=1 STRING: ENSP00000352257
    CREBBPQ927933, ENSP000002623674I2D: score=3 STRING: ENSP00000262367
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS1678287
    GO:0007275multicellular organismal development NAS2885844
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0030099myeloid cell differentiation IEA--

    HOXB7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXB7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB7 (HXB7)

    1 Novoseek inferred chemical compound relationship for HOXB7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 32.2 14 17514648 (3), 12536483 (2), 12212112 (1)

    Search CenterWatch for drugs/clinical trials and news about HOXB7 / HXB7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXB7 gene: 
    NM_004502.3  

    Unigene Cluster for HOXB7:

    Homeobox B7
    Hs.436181  [show with all ESTs]
    Unigene Representative Sequence: AK223249
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000239165(uc002inv.3) ENST00000567101 ENST00000467314 ENST00000433510
    ENST00000425510
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB7
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB7 (see all 11):
    hsa-miR-4283 hsa-miR-520d-5p hsa-miR-548v hsa-miR-3935 hsa-miR-1236 hsa-miR-337-3p hsa-miR-196a hsa-miR-3927
    SwitchGear 3'UTR luciferase reporter plasmidHOXB7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB7
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB7
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB7

    Additional mRNA sequence: 

    AK223249.1 AK290653.1 BC015345.1 M16937.1 M30598.1 

    3 DOTS entries:

    DT.446319  DT.92424265  DT.95299509 

    24/95 AceView cDNA sequences (see all 95):

    BE300551 BX116422 BG114527 AI628945 NM_004502 AI478205 BQ233410 BE465468 
    BE302874 AI871676 AI361891 AW445183 BM561113 AI475182 BF002423 AI380746 
    BF438390 AI701595 BG386772 AA587035 BF438003 CB141553 BQ005229 M30598 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB7 expression in normal human tissues (normalized intensities)      HOXB7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAAGGGAG
    HOXB7 Expression
    About this image


    HOXB7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 7 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Umbilical Vein Smooth Muscle Cells (HUVSMC)   
     
     Uncategorized (Uncategorized)    fully expand to see all 6 entries
             PureStem Progenitor W10
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             mK3
             Renal progenitor cells (Urteric bud-like cells) ( Stepwise renal lineage differentiation...
             Human Renal Mesangial Cells (HRMC)   
     
     Fibroblast
             Human Lymphatic Fibroblasts (HLF)   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   

    See HOXB7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB7

    SOURCE GeneReport for Unigene cluster: Hs.436181
        SABiosciences Expression via Pathway-Focused PCR Array including HOXB7: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXB7 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxb71 , 5 homeobox B71, 5 93.39(n)1
    94.01(a)1
      11 (59.82 cM)5
    154151  NM_010460.21  NP_034590.21 
     962866235 
    chicken
    (Gallus gallus)
    Aves HOXB71 homeobox B7 76.23(n)
    75.93(a)
      425962  XM_003642790.1  XP_003642838.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXB76
    Uncharacterized protein
    74(a)
    1 ↔ 1
    6(75614839-75621679)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.12102 Xenopus mRNA containing homeobox (XlHbox2) 81.78(n)    X06592.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxb7a1 homeo box B7a 66.05(n)
    60.65(a)
      58044  NM_001115091.1  NP_001108563.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Antp3 midgut development specific RNA
    polymerase II more
    82(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea mab-51 Protein MAB-5 45.09(n)
    43.93(a)
      176091  NM_066294.4  NP_498695.1 


    ENSEMBL Gene Tree for HOXB7 (if available)
    TreeFam Gene Tree for HOXB7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB7 gene
    GSX12  HOXA72  HOXA12  HOXB32  HOXD12  HOXA22  HOXB52  HOXC62  
    HOXC52  GSX22  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  
    HOXA32  HOXD82  HOXB62  HOXB12  HOXB82  HOXD42  HOXB22  PDX12  
    HOXC42  
    18/19 SIMAP similar genes for HOXB7 using alignment to 3 protein entries:     HXB7_HUMAN (see all proteins) (see all similar genes):
    HOX B6    HOXB4    HOXC13    HOXA-9    HOXA4    HOXA7
    HMX2    NKX6-1    HOXB1    HOXB8    HOXD8    HOXB5
    HOXA5    HOXB6    HOXC4    HOXC5    HOXC6    HOXA6

    HOXB7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/133 SNPs in HOXB7 are shown (see all 133)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1823860701,2
    --46684399(+) GTAAAG/TGGAAT 1 -- ds50010--------
    rs1466172551,2
    --46684407(+) AATGCA/CTGAGT 1 -- ds50010--------
    rs1401118301,2
    --46684421(+) ATATCA/GGGGTT 1 -- ds50010--------
    rs1498050301,2
    --46684440(+) GGCAGC/TCCCCC 1 -- ds50010--------
    rs1878294761,2
    --46684453(+) AGCAGA/GAGGCA 1 -- ds50010--------
    rs1466800901,2
    --46684633(+) TAGAT-/ACACACA 1 -- ut310--------
    rs793665131,2
    F--46684694(+) GCCAGG/ACGCTT 1 -- ut311Minor allele frequency- A:0.05WA 118
    rs1921176791,2
    --46684770(+) GGAGGC/GTCAGG 1 -- ut310--------
    rs1457382731,2
    C--46684782(+) GGGCAC/GGCAAC 1 -- ut310--------
    rs156891,2
    C,F,O,A,H--46684929(-) AAGGAT/CATTAT 1 -- ut3126Minor allele frequency- C:0.41MN NS EA NA WA CSA 2729

    HapMap Linkage Disequilibrium report for HOXB7 (46684594 - 46724385 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HOXB7:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676919CNV Deletion23128226
    dgv3223n71CNV Loss21882294
    dgv369n27CNV Loss19166990
    dgv3224n71CNV Loss21882294
    nsv833469CNV Loss17160897
    dgv3222n71CNV Loss21882294
    nsv833471CNV Gain17160897
    dgv988e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142962    OMIM disorders: --

    13 diseases for HOXB7:    About MalaCards
    cytomegalovirus infection    multiple myeloma    hirschsprung's disease    melanoma
    oral cancer    chronic lymphocytic leukemia    barrett's esophagus    myeloma
    neuroblastoma    breast cancer    lung cancer    leukemia
    endotheliitis


    HOXB7 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for HOXB7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cmv infection 33.4 1 12536483 (1)
    glioblastoma 32.3 3 17514648 (2), 9681827 (1)
    breast carcinoma 22.2 1 9681827 (1)
    breast cancer 13.9 4 10435624 (1), 9736453 (1), 12414653 (1)
    melanoma 6.68 4 8756643 (3), 9681827 (1)
    tumors 3.84 7 19956843 (2), 12697323 (2), 11274429 (1)
    leukemia 3.42 1 9681827 (1)
    cancer 0 3 15756441 (1)

    Genetic Association Database (GAD): HOXB7
    Human Genome Epidemiology (HuGE) Navigator: HOXB7 (1 document)

    Export disorders for HOXB7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB7 gene, integrated from 9 sources (see all 70):
    (articles sorted by number of sources associating them with HOXB7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Correlation between genetic variations in Hox clusters and Hirschsprung's disease. (PubMed id 17274802)1, 4 Garcia-Barcelo M.M....Tam P.K. (2007)
    2. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (2007)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    4. Lymphoid expression and TATAA binding of a human protein containing an Antennapedia homeodomain. (PubMed id 1678287)1, 2 Baier L.J.... Nabel G.J. (1991)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    6. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    7. Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. (PubMed id 2573064)1, 2 Shen W.-F.... Lawrence H.J. (1989)
    8. Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development. (PubMed id 2885844)1, 2 Simeone A....Peschle C. (1987)
    9. Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation. (PubMed id 10208421)1, 9 Care A....Peschle C. (1999)
    10. Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. (PubMed id 19956843)1, 9 De Souza Setubal Destro M.F....Coletta R.D. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3217 HGNC: 5118 AceView: HOXB7 Ensembl:ENSG00000260027 euGenes: HUgn3217
    ECgene: HOXB7 H-InvDB: HOXB7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HOXB7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXB7 gene:
    Search GeneIP for patents involving HOXB7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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