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Aliases for HOXB6 Gene

Aliases for HOXB6 Gene

  • Homeobox B6 2 3 5
  • Homeobox Protein Hox-2.2 3 4
  • Homeobox Protein Hox-2B 3 4
  • Homeobox Protein Hu-2 3 4
  • Homeo Box B6 2 3
  • HOX2B 3 4
  • Homeobox Protein Hox-B6 3
  • Homeo Box 2B 3
  • Hox-2.2 3
  • HOX2 3
  • HU-2 3

External Ids for HOXB6 Gene

Previous HGNC Symbols for HOXB6 Gene

  • HOX2
  • HOX2B

Previous GeneCards Identifiers for HOXB6 Gene

  • GC17M046384
  • GC17M049153
  • GC17M047015
  • GC17M047147
  • GC17M044028
  • GC17M046673
  • GC17M042041

Summaries for HOXB6 Gene

Entrez Gene Summary for HOXB6 Gene

  • This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB6 Gene

HOXB6 (Homeobox B6) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA6.

UniProtKB/Swiss-Prot for HOXB6 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB6 Gene

Genomics for HOXB6 Gene

Regulatory Elements for HOXB6 Gene

Enhancers for HOXB6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F048307 0.6 ENCODE 10.2 +297.0 296999 0.2 CTCF ZNF654 TRIM22 REST ZNF2 RAD21 CHAMP1 ZNF143 SMC3 MLLT1 HOXB6 SKAP1 HOXB9 HOXB-AS4 HOXB-AS1 HOXB2 SNX11 CBX1 EGID-105371807 ENSG00000266222
GH17F048538 1.7 VISTA FANTOM5 Ensembl ENCODE 8.1 +31.8 31827 68.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A FEZF1 ZNF2 YY1 ZNF143 HOXB2 SKAP1 RN7SL125P GIP LOC105371815 ENSG00000251461 ENSG00000264243 LINC02075 HOXB9 HOXB3
GH17F048623 0.9 FANTOM5 ENCODE 2.5 -21.7 -21659 6.4 HDGF PKNOX1 ARNT CREB3L1 SIN3A FEZF1 CBX5 SP3 REST MEF2D ENSG00000264701 LRRC46 TBX21 HOXB9 PRAC2 PRAC1 HOXB13 LOC105371811 HOXB2 HOXB8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HOXB6 on UCSC Golden Path with GeneCards custom track

Promoters for HOXB6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001348234 1292 3001 PKNOX1 SIN3A FEZF1 GLI4 ZNF2 GLIS2 ZNF143 SP3 TSHZ1 REST

Genomic Location for HOXB6 Gene

Chromosome:
17
Start:
48,594,095 bp from pter
End:
48,604,992 bp from pter
Size:
10,898 bases
Orientation:
Minus strand

Genomic View for HOXB6 Gene

Genes around HOXB6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB6 Gene

Proteins for HOXB6 Gene

  • Protein details for HOXB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17509-HXB6_HUMAN
    Recommended name:
    Homeobox protein Hox-B6
    Protein Accession:
    P17509
    Secondary Accessions:
    • A8K835
    • D3DTV5
    • P09068
    • Q9HB11
    • Q9UGH2

    Protein attributes for HOXB6 Gene

    Size:
    224 amino acids
    Molecular mass:
    25432 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HOXB6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOXB6 Gene

Post-translational modifications for HOXB6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB6 Gene

No data available for DME Specific Peptides for HOXB6 Gene

Domains & Families for HOXB6 Gene

Gene Families for HOXB6 Gene

Suggested Antigen Peptide Sequences for HOXB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17509

UniProtKB/Swiss-Prot:

HXB6_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB6: view

Function for HOXB6 Gene

Molecular function for HOXB6 Gene

GENATLAS Biochemistry:
homeo box B6(2B),homologous to mouse Hox-2.2,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with HOXB6: view
genes like me logo Genes that share phenotypes with HOXB6: view

Animal Models for HOXB6 Gene

MGI Knock Outs for HOXB6:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXB6

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB6 Gene

Localization for HOXB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB6 Gene COMPARTMENTS Subcellular localization image for HOXB6 gene
Compartment Confidence
nucleus 5
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for HOXB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXB6: view

Pathways & Interactions for HOXB6 Gene

SuperPathways for HOXB6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0034101 erythrocyte homeostasis IEA --
genes like me logo Genes that share ontologies with HOXB6: view

No data available for Pathways by source and SIGNOR curated interactions for HOXB6 Gene

Transcripts for HOXB6 Gene

Unigene Clusters for HOXB6 Gene

Homeobox B6:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXB6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: - - -
SP2:
SP3:

Relevant External Links for HOXB6 Gene

GeneLoc Exon Structure for
HOXB6
ECgene alternative splicing isoforms for
HOXB6

Expression for HOXB6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOXB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB6 Gene

This gene is overexpressed in Kidney - Cortex (x9.8), Colon - Transverse (x7.5), and Cervix - Endocervix (x4.9).

NURSA nuclear receptor signaling pathways regulating expression of HOXB6 Gene:

HOXB6

SOURCE GeneReport for Unigene cluster for HOXB6 Gene:

Hs.98428
genes like me logo Genes that share expression patterns with HOXB6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HOXB6 Gene

Orthologs for HOXB6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB6 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia HOXB6 34 35
  • 94.2 (n)
rat
(Rattus norvegicus)
Mammalia Hoxb6 34
  • 91.37 (n)
mouse
(Mus musculus)
Mammalia Hoxb6 34 16 35
  • 91.22 (n)
cow
(Bos Taurus)
Mammalia HOXB6 34
  • 88.45 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXB6 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB6 34 35
  • 77.63 (n)
lizard
(Anolis carolinensis)
Reptilia HOXB6 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb6 34
  • 71.15 (n)
Str.9720 34
zebrafish
(Danio rerio)
Actinopterygii hoxb6a 34 35
  • 69.08 (n)
hoxb6b 35
  • 61 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13884 34
fruit fly
(Drosophila melanogaster)
Insecta Antp 35
  • 24 (a)
OneToMany
Species where no ortholog for HOXB6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB6 Gene

ENSEMBL:
Gene Tree for HOXB6 (if available)
TreeFam:
Gene Tree for HOXB6 (if available)

Paralogs for HOXB6 Gene

(12) SIMAP similar genes for HOXB6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXB6: view

Variants for HOXB6 Gene

Sequence variations from dbSNP and Humsavar for HOXB6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs756724993 Uncertain significance 48,596,652(+) CCGGC(C/T)GCTGG intron-variant, reference, missense
rs762346893 Uncertain significance 48,598,060(+) ATAGC(C/G/T)CGACG intron-variant, reference, missense
rs1060030 -- 48,606,300(+) TCCCC(A/C)CCCCC nc-transcript-variant, upstream-variant-2KB
rs1064739 -- 48,606,293(+) ATTCC(C/T)TTCCC nc-transcript-variant, upstream-variant-2KB
rs10853101 -- 48,599,098(+) GAAAG(A/G)GACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXB6 Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv2758694 CNV gain 17122850
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Variation tolerance for HOXB6 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.26; 25.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB6 Gene

Human Gene Mutation Database (HGMD)
HOXB6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB6 Gene

Disorders for HOXB6 Gene

Relevant External Links for HOXB6

Genetic Association Database (GAD)
HOXB6
Human Genome Epidemiology (HuGE) Navigator
HOXB6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB6

No disorders were found for HOXB6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB6 Gene

Publications for HOXB6 Gene

  1. Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias. (PMID: 17003840) Chen T. … Shen Y. (Eur. J. Hum. Genet. 2007) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
  4. Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. (PMID: 1672751) Shen W.-F. … Largman C. (Nucleic Acids Res. 1991) 3 4 64
  5. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3 64

Products for HOXB6 Gene

Sources for HOXB6 Gene

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