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Aliases for HOXB6 Gene

Aliases for HOXB6 Gene

  • Homeobox B6 2 3
  • HOX2B 3 4 6
  • Homeobox Protein Hox-2.2 3 4
  • Homeobox Protein Hox-2B 3 4
  • Homeobox Protein Hu-2 3 4
  • Homeo Box B6 2 3
  • Homeobox Protein Hox-B6 3
  • Homeo Box 2B 3
  • Hox-2.2 3
  • HU-2 3
  • HOX2 3

External Ids for HOXB6 Gene

Previous HGNC Symbols for HOXB6 Gene

  • HOX2
  • HOX2B

Previous GeneCards Identifiers for HOXB6 Gene

  • GC17M046384
  • GC17M049153
  • GC17M047015
  • GC17M047147
  • GC17M044028
  • GC17M046673
  • GC17M042041

Summaries for HOXB6 Gene

Entrez Gene Summary for HOXB6 Gene

  • This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB6 Gene

HOXB6 (Homeobox B6) is a Protein Coding gene. Diseases associated with HOXB6 include myeloid leukemia and colorectal cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXB6 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB6 Gene

Genomics for HOXB6 Gene

Regulatory Elements for HOXB6 Gene

Transcription factor binding sites by QIAGEN in the HOXB6 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXB6 Gene

Start:
48,594,095 bp from pter
End:
48,604,992 bp from pter
Size:
10,898 bases
Orientation:
Minus strand

Genomic View for HOXB6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB6 Gene

Proteins for HOXB6 Gene

  • Protein details for HOXB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17509-HXB6_HUMAN
    Recommended name:
    Homeobox protein Hox-B6
    Protein Accession:
    P17509
    Secondary Accessions:
    • A8K835
    • D3DTV5
    • P09068
    • Q9HB11
    • Q9UGH2

    Protein attributes for HOXB6 Gene

    Size:
    224 amino acids
    Molecular mass:
    25432 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HOXB6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOXB6 Gene

Proteomics data for HOXB6 Gene at MOPED

Post-translational modifications for HOXB6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB6 Gene

Domains for HOXB6 Gene

Gene Families for HOXB6 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXB6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17509

UniProtKB/Swiss-Prot:

HXB6_HUMAN :
  • P17509
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB6: view

Function for HOXB6 Gene

Molecular function for HOXB6 Gene

GENATLAS Biochemistry:
homeo box B6(2B),homologous to mouse Hox-2.2,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with HOXB6: view
genes like me logo Genes that share phenotypes with HOXB6: view

Animal Models for HOXB6 Gene

MGI Knock Outs for HOXB6:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXB6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HOXB6 Gene

Localization for HOXB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB6 Gene COMPARTMENTS Subcellular localization image for HOXB6 gene
Compartment Confidence
nucleus 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HOXB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXB6: view

Pathways for HOXB6 Gene

SuperPathways for HOXB6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
GO:0034101 erythrocyte homeostasis IEA --
GO:0048704 embryonic skeletal system morphogenesis IEA --
genes like me logo Genes that share ontologies with HOXB6: view

No data available for Pathways by source for HOXB6 Gene

Transcripts for HOXB6 Gene

Unigene Clusters for HOXB6 Gene

Homeobox B6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXB6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
SP1: - - -
SP2:
SP3:

Relevant External Links for HOXB6 Gene

GeneLoc Exon Structure for
HOXB6
ECgene alternative splicing isoforms for
HOXB6

Expression for HOXB6 Gene

mRNA expression in normal human tissues for HOXB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB6 Gene

This gene is overexpressed in Kidney - Cortex (9.8), Colon - Transverse (7.5), and Cervix - Endocervix (4.9).

SOURCE GeneReport for Unigene cluster for HOXB6 Gene Hs.98428

genes like me logo Genes that share expressions with HOXB6: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for HOXB6 Gene

Orthologs for HOXB6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXB6 35
  • 88.45 (n)
  • 92.57 (a)
dog
(Canis familiaris)
Mammalia HOXB6 35
  • 94.2 (n)
  • 97.32 (a)
HOXB6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb6 35
  • 91.22 (n)
  • 97.77 (a)
Hoxb6 16
Hoxb6 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXB6 35
  • 100 (n)
  • 100 (a)
HOXB6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb6 35
  • 91.37 (n)
  • 97.77 (a)
oppossum
(Monodelphis domestica)
Mammalia HOXB6 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB6 35
  • 77.63 (n)
  • 80.09 (a)
HOXB6 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXB6 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb6 35
  • 71.15 (n)
  • 73.99 (a)
Str.9720 35
zebrafish
(Danio rerio)
Actinopterygii hoxb6a 35
  • 69.08 (n)
  • 71.95 (a)
hoxb6a 36
  • 69 (a)
OneToMany
hoxb6b 36
  • 61 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13884 35
fruit fly
(Drosophila melanogaster)
Insecta Antp 36
  • 24 (a)
OneToMany
Species with no ortholog for HOXB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB6 Gene

ENSEMBL:
Gene Tree for HOXB6 (if available)
TreeFam:
Gene Tree for HOXB6 (if available)

Paralogs for HOXB6 Gene

Selected SIMAP similar genes for HOXB6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXB6: view

Variants for HOXB6 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXB6 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990

Relevant External Links for HOXB6 Gene

HapMap Linkage Disequilibrium report
HOXB6
Human Gene Mutation Database (HGMD)
HOXB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HOXB6 Gene

Disorders for HOXB6 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HOXB6 Gene in MalaCards »

(2) Diseases for HOXB6 Gene including...

Relevant External Links for HOXB6

Genetic Association Database (GAD)
HOXB6
Human Genome Epidemiology (HuGE) Navigator
HOXB6
genes like me logo Genes that share disorders with HOXB6: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HOXB6 Gene

Publications for HOXB6 Gene

  1. Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. (PMID: 6091895) Levine M. … Tjian R. (Cell 1984) 3 4
  2. Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. (PMID: 1672751) Shen W.-F. … Largman C. (Nucleic Acids Res. 1991) 3 4
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. (PMID: 2573064) Shen W.-F. … Lawrence H.J. (Proc. Natl. Acad. Sci. U.S.A. 1989) 3 4
  5. Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias. (PMID: 17003840) Chen T. … Shen Y. (Eur. J. Hum. Genet. 2007) 3 48

Products for HOXB6 Gene

Sources for HOXB6 Gene

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