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HOXB6 Gene

protein-coding   GIFtS: 51
GCID: GC17M046673

Homeobox B6

(Previous name: homeo box B6)
(Previous symbols: HOX2, HOX2B)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox B61 2     Homeobox Protein Hu-22 3
HOX2B1 2 3 5     HU-22
HOX21 2     Hox-2.22
Homeo Box B61 2     Homeo Box 2B2
Homeobox Protein Hox-2.22 3     Homeobox Protein Hox-B62
Homeobox Protein Hox-2B2 3     

External Ids:    HGNC: 51171   Entrez Gene: 32162   Ensembl: ENSG000001085117   OMIM: 1429615   UniProtKB: P175093   

Export aliases for HOXB6 gene to outside databases

Previous GC identifers: GC17M046384 GC17M049153 GC17M047015 GC17M047147 GC17M044028 GC17M042041


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXB6 Gene:
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a
sequence-specific transcription factor that is involved in development, including that of lung and skin, and has
been localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular
localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB6 Gene:
HOXB6 (homeobox B6) is a protein-coding gene. Diseases associated with HOXB6 include primary pulmonary hypertension, and hypospadias. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXB6 gene promoter:
         E2F   AP-1   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB6 promoter sequence
   Search Chromatin IP Primers for HOXB6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXB6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046673:  view genomic region     (about GC identifiers)

Start:
46,671,639 bp from pter      End:
46,682,354 bp from pter
Size:
10,716 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509 (See protein sequence)
Recommended Name: Homeobox protein Hox-B6  
Size: 224 amino acids; 25432 Da
Secondary accessions: A8K835 D3DTV5 P09068 Q9HB11 Q9UGH2
Alternative splicing: 2 isoforms:  P17509-1   P17509-2   

Explore the universe of human proteins at neXtProt for HOXB6: NX_P17509

Explore proteomics data for HOXB6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXB6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061825.2  
    ENSEMBL proteins: 
     ENSP00000420009   ENSP00000225648  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry P17509

    ProtoNet protein and cluster: P17509

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXB6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB6_HUMAN, P17509
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB6:
    homeo box B6(2B),homologous to mouse Hox-2.2,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    HOXB6 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxb6):
     hematopoietic system  immune system  nervous system  skeleton 

    HOXB6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXB6: Hoxb6tm1Cka Hoxb6tm1Mrc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXB6
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    Selected qRT-PCR Assays for microRNAs that regulate HOXB6 (see all 32):
    hsa-miR-877* hsa-miR-376c hsa-miR-3174 hsa-miR-3163 hsa-miR-1283 hsa-miR-335 hsa-miR-3667-3p hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHOXB6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXB6_HUMAN, P17509: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXB6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HOXB6
    Interactions:

        GeneGlobe Interaction Network for HOXB6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for HOXB6 (P175092, 3 ENSP000002256484) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-67624 I2D: score=5 STRING: ENSP00000254043
    SAT1P216732, 3, ENSP000003685724MINT-66153 I2D: score=5 STRING: ENSP00000368572
    CSNK2BP678703, ENSP000003650254I2D: score=1 STRING: ENSP00000365025
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0008595anterior/posterior axis specification, embryo ----
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0034101erythrocyte homeostasis IEA--

    HOXB6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXB6 (HXB6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOXB6 gene (3 alternative transcripts): 
    NM_018952.4  NM_156036.1  NM_156037.1  

    Unigene Cluster for HOXB6:

    Homeobox B6
    Hs.98428  [show with all ESTs]
    Unigene Representative Sequence: AK292200
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484302(uc002ins.1 uc010dbh.1) ENST00000225648 ENST00000470193
    ENST00000490419
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate HOXB6 (see all 32):
    hsa-miR-877* hsa-miR-376c hsa-miR-3174 hsa-miR-3163 hsa-miR-1283 hsa-miR-335 hsa-miR-3667-3p hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmidHOXB6 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: HOXB6 (NM_018952)
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    OriGene qPCR primer pairs and template standards for HOXB6
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB6
      QuantiTect SYBR Green Assays in human, mouse, rat HOXB6
      QuantiFast Probe-based Assays in human, mouse, rat HOXB6

    Additional mRNA sequence: 

    AK292200.1 BC014651.1 M30597.1 S69023.1 

    5 DOTS entries:

    DT.411550  DT.40284863  DT.100751617  DT.86853413  DT.92434281 

    Selected AceView cDNA sequences (see all 119):

    BF001683 AI581159 AW079372 AI393078 BQ930769 CF127170 AI739272 AI262967 
    AW780031 AI078264 AI935193 BI764435 AW439180 AW204721 AA433830 AA416576 
    BQ897315 AA442194 CA434999 NM_156036 BC014651 BX115208 BQ695093 AI887979 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HOXB6    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
    SP1:        -           -                 -               
    SP2:                                                      
    SP3:                                                      


    ECgene alternative splicing isoforms for HOXB6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXB6 expression in normal human tissues (normalized intensities)      HOXB6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGTGGAAAA
    HOXB6 Expression
    About this image


    HOXB6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Cartilage (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Somite (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Tendon & Ligament
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Bone (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
    HOXB6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXB6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98428
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOXB6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxb61 , 5 homeobox B61, 5 91.22(n)1
    97.77(a)1
      11 (59.82 cM)5
    154141  NM_008269.11  NP_032295.11 
     962924765 
    chicken
    (Gallus gallus)
    Aves HOXB61 homeobox B6 77.63(n)
    80.09(a)
      777548  XM_001236989.3  XP_001236990.2 
    lizard
    (Anolis carolinensis)
    Reptilia HOXB66
    homeobox B6
    76(a)
    1 ↔ 1
    6(75598780-75603650)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.97202 Transcribed sequence with moderate similarity to protein more 78.95(n)    BX727472.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxb6a2 homeo box B6a 73.59(n)   30341  NM_131119.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Antp6
    Antennapedia
    24(a)
    1 → many
    3R(2721975-2824950)


    ENSEMBL Gene Tree for HOXB6 (if available)
    TreeFam Gene Tree for HOXB6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXB6 gene
    HOXA72  HOXB52  HOXC62  HOXC52  HOXB42  HOXA52  ENSG000002732662  HOXA42  
    HOXC82  HOXA62  ENSG000002730492  HOXD82  HOXB82  HOXD42  HOXB72  HOXC42  
    12 SIMAP similar genes for HOXB6 using alignment to 1 protein entry:     HXB6_HUMAN:
    HOXA4    HOXA6    HOXC6    HOXB8    HOXA5    HOXC5
    HOXB7    HOXC4    HOXD8    HOXD3    HOXB4    HOXC8

    HOXB6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    6 SNPs for HOXB6    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3750751881,2
    C,F--46673168(+) attat-/TATCAT/TAT
    TAT
    /TATTATCAT
    catca
    3 -- cds12NA CSA 4
    rs589022301,2
    C--46678382(+) GTGTG-/T/TG  
            
    GTGTG
    1 -- int10--------
    rs353074731,2
    ----46673193(+) TCATC-/ATCGAAGT 1 -- cds10--------
    rs30545581,2
    ----46673168(+) attatC/Tatcat 2 -- ut310--------
    rs711445061,2
    ----46678381(+) GTGTG-/TGGTGTG 1 -- int11Minor allele frequency- TG:0.00NA 2
    rs581800601,2
    ----46678375(+) GTGTG-/TGT   
       GTGTG
    GTGTG
    1 -- int10--------

    HapMap Linkage Disequilibrium report for HOXB6 (46671639 - 46682354 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOXB6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833469CNV Loss17160897
    dgv3222n71CNV Loss21882294
    dgv3223n71CNV Loss21882294
    dgv369n27CNV Loss19166990
    dgv3224n71CNV Loss21882294
    nsv833471CNV Gain17160897
    dgv988e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): HOXB6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXB6
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXB6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142961    OMIM disorders: --

    13 diseases for HOXB6:    About MalaCards
    primary pulmonary hypertension    hypospadias    myeloid leukemia    acute myeloid leukemia
    colorectal cancer    barrett's esophagus    leukemia    hypertension
    neuroblastoma    multiple sclerosis    cervicitis    endotheliitis
    neuronitis


    HOXB6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HOXB6
    Human Genome Epidemiology (HuGE) Navigator: HOXB6 (2 documents)

    Export disorders for HOXB6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXB6 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with HOXB6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias. (PubMed id 17003840)1, 4 Chen T....Shen Y. (Eur. J. Hum. Genet. 2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    4. Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. (PubMed id 1672751)1, 2 Shen W.-F....Largman C. (Nucleic Acids Res. 1991)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    6. Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. (PubMed id 2573064)1, 2 Shen W.-F.... Lawrence H.J. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    7. Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. (PubMed id 6091895)1, 2 Levine M.... Tjian R. (Cell 1984)
    8. Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus. (PubMed id 22603795)1 di Pietro M....Fitzgerald R.C. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    9. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
    10. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)4 Jugessur A....Murray J.C. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3216 HGNC: 5117 AceView: HOXB6 Ensembl:ENSG00000108511 euGenes: HUgn3216
    ECgene: HOXB6 H-InvDB: HOXB6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXB6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXB6 gene:
    Search GeneIP for patents involving HOXB6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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