Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB6 Gene

protein-coding   GIFtS: 52
GCID: GC17M046673

homeobox B6

(Previous name: homeo box B6 )
(Previous symbols: HOX2, HOX2B)
 Explore 12 diseases affiliated with
HOXB6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXB6    

Aliases
for HOXB6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox B61 2     Homeobox Protein Hu-22 3
HOX2B1 2 3 5     HU-22
HOX21 2     Hox-2.22
Homeo Box B61 2     Homeo Box 2B2
Homeobox Protein Hox-2.22 3     Homeobox Protein Hox-B62
Homeobox Protein Hox-2B2 3     

External Ids:    HGNC: 51171   Entrez Gene: 32162   Ensembl: ENSG000001085117   OMIM: 1429615   UniProtKB: P175093   

Export aliases for HOXB6 gene to outside databases

Previous GC identifers: GC17M046384 GC17M049153 GC17M047015 GC17M047147 GC17M044028 GC17M042041


Summaries
for HOXB6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXB6:
This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is
included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a
sequence-specific transcription factor that is involved in development, including that of lung and skin, and has been
localized to both the nucleus and cytoplasm. Altered expression of this gene or a change in the subcellular
localization of its protein is associated with some cases of acute myeloid leukemia and colorectal cancer. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB6


Genomic Views
for HOXB6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB6 gene promoter:
         E2F   AP-1   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXB6 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046673:  view genomic region     (about GC identifiers)

Start:
 46,671,639 bp from pter      End:
 46,682,354 bp from pter
Size:
 10,716 bases      Orientation:
 minus strand

Proteins
for HOXB6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509 (See protein sequence)
Recommended Name: Homeobox protein Hox-B6  
Size: 224 amino acids; 25432 Da
Subcellular location: Nucleus
Secondary accessions: A8K835 D3DTV5 P09068 Q9HB11 Q9UGH2
Alternative splicing: 2 isoforms:  P17509-1   P17509-2   

Explore the universe of human proteins at neXtProt for HOXB6: NX_P17509

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17509

    • HOXB6 Protein expression data from MOPED and PaxDb:    About this image 
    HOXB6 Protein Expression
    REFSEQ proteins: NP_061825.2  
    ENSEMBL proteins: 
     ENSP00000420009   ENSP00000225648  

    Human Recombinant Protein Products for HOXB6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: HOXB6
    OriGene Protein Over-expression Lysate: HOXB6
    OriGene Custom Protein Services for HOXB6 
    GenScript Custom Purified and Recombinant Proteins Services for HOXB6
    Novus Biologicals HOXB6 Proteins
    Novus Biologicals HOXB6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXB6

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--

    HOXB6 for ontologies           About GeneDecksing



    HOXB6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HOXB6 
    GenScript Custom Superior Antibodies Services for HOXB6
    Novus Biologicals HOXB6 Antibody
    Abcam antibodies for HOXB6 
    Uscn Antibodies for HOXB6
    Search ThermoFisher Antibodies for HOXB6

    Assay Products for HOXB6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXB6
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for HOXB6

    Protein Domains /
    Families
    for HOXB6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXB6 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P17509

    ProtoNet protein and cluster: P17509

    1 Blocks protein family: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXB6_HUMAN, P17509
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXB6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB6_HUMAN, P17509
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB6:
    homeo box B6(2B),homologous to mouse Hox-2.2,Drosophila Antp,Ubx,abd-A,expressed during early myelopoiesis

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXB6 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hoxb6):
     hematopoietic system  immune system  nervous system  skeleton 

    HOXB6 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for HOXB6: Hoxb6tm1Cka Hoxb6tm1Mrc
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOXB6 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HOXB6
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB6
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB6 (see all 32):
    hsa-miR-877* hsa-miR-376c hsa-miR-3174 hsa-miR-3163 hsa-miR-1283 hsa-miR-335 hsa-miR-3667-3p hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB6 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB6 (see all 4)
    OriGene shRNA RFP: HOXB6
    OriGene siRNA: HOXB6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB6
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXB6 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXB6
    Sirion Biotech Customized adenovirus for overexpression of HOXB6 
    Sirion Biotech Customized adenovirus for potent knockdown of HOXB6

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB6 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXB6 (NM_018952)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB6 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HOXB6
    Search LifeMap BioReagents cell lines for HOXB6
    Sirion Biotech Customized stable knockdown cell line services for HOXB6 
    Sirion Biotech Customized inducible knockdown cell line services for HOXB6
    Sirion Biotech Customized stable overexpressing cell line services for HOXB6
    Sirion Biotech Customized inducible overexpressing cell line services for HOXB6

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB6


    Pathways & Interactions
    for HOXB6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/12 Interacting proteins for HOXB6 (P175092, 3 ENSP000002256484) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRT15P190122, 3, ENSP000002540434MINT-67624 I2D: score=5 STRING: ENSP00000254043
    SAT1P216732, 3, ENSP000003685724MINT-66153 I2D: score=5 STRING: ENSP00000368572
    PLSCR1O151622, 3, ENSP000003454944MINT-66992 I2D: score=5 STRING: ENSP00000345494
    ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
    CSNK2BP678703, ENSP000003650254I2D: score=1 STRING: ENSP00000365025
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0008595anterior/posterior axis specification, embryo NAS--
    GO:0009952anterior/posterior pattern specification ----
    GO:0034101erythrocyte homeostasis IEA--

    HOXB6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXB6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB6
    Search CenterWatch for drugs/clinical trials and news about HOXB6 / HXB6 

    Transcripts
    for HOXB6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXB6 gene (3 alternative transcripts): 
    NM_018952.4  NM_156036.1  NM_156037.1  

    Unigene Cluster for HOXB6:

    Homeobox B6
    Hs.98428  [show with all ESTs]
    Unigene Representative Sequence: AK292200
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484302(uc002ins.1 uc010dbh.1) ENST00000225648 ENST00000470193
    ENST00000490419

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HOXB6
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB6
    8/32 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB6 (see all 32):
    hsa-miR-877* hsa-miR-376c hsa-miR-3174 hsa-miR-3163 hsa-miR-1283 hsa-miR-335 hsa-miR-3667-3p hsa-miR-199a-5p
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB6 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB6 (see all 4)
    OriGene shRNA RFP: HOXB6
    OriGene siRNA: HOXB6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB6
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXB6 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB6 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXB6 (NM_018952)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB6 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB6

    Additional cDNA sequence: 

    AK292200.1 BC014651.1 M30597.1 S69023.1 

    5 DOTS entries:

    DT.411550  DT.40284863  DT.100751617  DT.86853413  DT.92434281 

    24/119 AceView cDNA sequences (see all 119):

    AI078264 AW079372 BQ930769 CF127170 AI262967 AI581159 AW780031 AI393078 
    BF001683 AI739272 BG470218 AW204721 AI337398 BG332853 CA434999 BQ695093 
    BX115208 NM_156037 BG430754 BQ897315 AI262637 BI764435 AW439180 BE908889 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for HOXB6    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b
    SP1:        -           -                 -               
    SP2:                                                      
    SP3:                                                      


    ECgene alternative splicing isoforms for HOXB6

    Expression
    for HOXB6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGTGGAAAA
    HOXB6 Expression
    About this image

    HOXB6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    SomiteCervical Mesenchymal SclerotomeCervical Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    KidneyMetanephrosKidney
    LimbLimb BudLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Motor neuron-like cells (Generation of motor ...)Motor Neurons, Spinal Cord
    GABA neuron-like cells (Generation of motor ...)Brain

    See HOXB6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB6

    SOURCE GeneReport for Unigene cluster: Hs.98428
        SABiosciences Custom PCR Arrays for HOXB6
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB6
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB6
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB6

    Orthologs
    for HOXB6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXB6 gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC7775481 homeobox protein Hox-B6-like 77.63(n)
    80.09(a)    		   777548  XM_001236989.2  XP_001236990.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXB66
    		 --
    		 75(a)
    		 1 ↔ 1
    		 6(75600174-75603650)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.97202 Transcribed sequence with moderate similarity to protein more 78.95(n)    BX727472.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxb6a2 homeo box B6a 73.59(n)   30341  NM_131119.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta zen26
    zen6
    		 zerknullt
    		 16(a)
    12(a)
    		 possible ortholog
    possible ortholog
    		 3R(2568854-2569862)
    3R(2578586-2579916)
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-396
    		 Homeobox protein lin-39
    		 21(a)
    		 possible ortholog
    		 III(7528603-7536567)


    ENSEMBL Gene Tree for HOXB6 (if available)
    TreeFam Gene Tree for HOXB6 (if available) 

    Paralogs
    for HOXB6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB6 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXB42  HOXA52  HOXA42  HOXD32  HOXC82  HOXA62  
    HOXA32  HOXD82  HOXB12  HOXB82  HOXD42  HOXB22  HOXB72  PDX12  
    HOXC42  
    12 SIMAP similar genes for HOXB6 using alignment to 1 protein entry:     HXB6_HUMAN:
    HOXA4    HOXA6    HOXC6    HOXB8    HOXA5    HOXC5
    HOXB7    HOXC4    HOXD8    HOXD3    HOXB4    HOXC8

    HOXB6 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXB6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/181 NCBI SNPs in HOXB6 are shown (see all 181)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1403021171,2
    		--46673116(+) CGTCGA/GGTTTT 6 -- us2k1 int1 ut310--------
    rs49896721,2
    		--46673149(+) TTGTTA/GTTATT 6 -- us2k1 int1 ut310--------
    rs1878600861,2
    		--46673152(+) TTGTTA/GTTATT 6 -- us2k1 int1 ut310--------
    rs728298801,2
    		--46673166(+) ATTATC/TATCAT 6 -- ut31 us2k1 int10--------
    rs1391722891,2
    		--46673166(+) TTATT-/ATCATCAT 6 -- ut31 us2k1 int10--------
    rs761512631,2
    		--46673169(+) ATTATC/TATCAT 6 -- ut31 us2k1 int10--------
    rs1454585951,2
    		--46673174(+) CATCAC/TCATCA 6 -- ut31 us2k1 int10--------
    rs746633971,2
    		F--46673194(+) TCATCG/AAAGTA 6 -- ut31 int1 us2k11Minor allele frequency- A:0.06WA 118
    rs781713651,2
    		--46673206(+) TTCACG/TTCCAG 6 -- us2k1 int1 ut310--------
    rs1927228361,2
    		--46673373(+) CTTCAA/GGGCCC 6 -- ut31 nc-transcript-variantint10--------

    HapMap Linkage Disequilibrium report for HOXB6 (46671639 - 46682354 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for HOXB6
         2 CNVs: 53230 4040
    Human Gene Mutation Database (HGMD): HOXB6

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB6
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXB6

    Disorders / Diseases
    for HOXB6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXB6 for disorders           About GeneDecksing

    OMIM gene information: 142961    OMIM disorders: --

    12 diseases for HOXB6:    About MalaCards
    acute myeloid leukemia    myeloid leukemia    colorectal cancer    leukemia
    primary pulmonary hypertension    pulmonary hypertension    hypospadias    multiple sclerosis
    emphysema    hypertension    colon cancer    neuroblastoma

    Human Genome Epidemiology (HuGE) Navigator: HOXB6 (2 documents)

    Export disorders for HOXB6 gene to outside databases

    Publications
    for HOXB6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB6 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with HOXB6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    3. Alternative splicing of the HOX 2.2 homeobox gene in human hematopoietic cells and murine embryonic and adult tissues. (PubMed id 1672751)1, 2 Shen W.-F....Largman C. (1991)
    4. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    5. Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. (PubMed id 2573064)1, 2 Shen W.-F.... Lawrence H.J. (1989)
    6. Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. (PubMed id 6091895)1, 2 Levine M.... Tjian R. (1984)
    7. Evidence for a functional role of epigenetically regul ated midcluster HOXB genes in the development of Barrett esophagus. (PubMed id 22603795)1 di Pietro M....Fitzgerald R.C. (2012)
    8. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    9. Induction of HoxB transcription by retinoic acid requ ires actin polymerization. (PubMed id 19477923)1 Ferrai C....Blasi F. (2009)
    10. Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias. (PubMed id 17003840)1 Chen T....Shen Y. (2007)

    External Searches for HOXB6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXB6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3216 HGNC: 5117 AceView: HOXB6 Ensembl:ENSG00000108511 euGenes: HUgn3216
    ECgene: HOXB6 H-InvDB: HOXB6

    Other Databases showing HOXB6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXB6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXB6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXB6 gene:
    Search GeneIP for patents involving HOXB6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HOXB6 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for HOXB6  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB6   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB6  
     OriGene Protein Over-expression Lysate for HOXB6   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for HOXB6   OriGene 3'-UTR Clone for HOXB6  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB6   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB6  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for HOXB6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXB6   OriGene Custom Protein Services for HOXB6  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HOXB6
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB6
     GenScript Custom Purified and Recombinant Proteins Services for HOXB6 GenScript cDNA clones with any tag delivered in your preferred vector for HOXB6
     GenScript Custom Assay Services for HOXB6 GenScript Custom Superior Antibodies Services for HOXB6
     GenScript Custom overexpressing Cell Line Services for HOXB6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXB6 promoter
     Search Chromatin IP Primers for HOXB6
     RT2 qPCR Primer Assay in human, mouse, rat HOXB6
     GNC Network for HOXB6
     SABiosciences Custom PCR Arrays for HOXB6
     Search Tocris compounds for HOXB6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HOXB6 antibodies
     HOXB6 proteins
     HOXB6 lysates
     Antibodies for HOXB6
     See all of Abcam's Antibodies, Kits and Proteins for HOXB6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     HOXB6 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for HOXB6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB6
     SwitchGear 3'UTR luciferase reporter plasmids for HOXB6
     SwitchGear Promoter luciferase reporter plasmids for HOXB6
     Search ThermoFisher Antibodies for HOXB6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB6
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOXB6
    Sirion Biotech Customized:
     stable knockdown cell line services for HOXB6
     inducible knockdown cell line services for HOXB6
     design and validation of potent shRNA sequences against HOXB6
     adenovirus for potent knockdown of HOXB6
     adenovirus for overexpression of HOXB6
     stable overexpressing cell line services for HOXB6
     inducible overexpressing cell line services for HOXB6
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HOXB6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4