Aliases for HOXB5 Gene
Aliases for HOXB5 Gene
External Ids for HOXB5 Gene
- HGNC: 5116
- Entrez Gene: 3215
- Ensembl: ENSG00000120075
- OMIM: 142960
- UniProtKB: P09067
Previous HGNC Symbols for HOXB5 Gene
- HOX2
- HOX2A
Previous GeneCards Identifiers for HOXB5 Gene
- GC17M046379
- GC17M049149
- GC17M047010
- GC17M047143
- GC17M044023
- GC17M046668
- GC17M042037
Summaries for HOXB5 Gene
-
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB5 Gene
HOXB5 (Homeobox B5) is a Protein Coding gene. Diseases associated with HOXB5 include Hirschsprung Disease 1. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is HOXA5.
UniProtKB/Swiss-Prot for HOXB5 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB5 Gene
Genomics for HOXB5 Gene
Regulatory Elements for HOXB5 Gene
Enhancers for HOXB5 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH17G048538 | 2.3 | VISTA FANTOM5 Ensembl ENCODE dbSUPER | 4.6 | +20.8 | 20796 | 68.8 | CREB3L1 AGO1 FEZF1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ZNF610 | HOXB2 SKAP1 HOXB9 HOXB3 ENSG00000264701 HOXB-AS1 HOXB-AS3 SUMO2P17 HOXB-AS4 HOXB1 |
| GH17G048623 | 1.7 | FANTOM5 ENCODE dbSUPER | 2.5 | -32.7 | -32690 | 6.4 | HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A FEZF1 ZNF766 CBX5 SP3 | ENSG00000264701 HOXB9 PRAC2 PRAC1 HOXB13 LOC105371811 HOXB2 HOXB8 HOXB5 HOXB6 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXB5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXB5 gene promoter:
Regulatory Element Products
Genomic Location for HOXB5 Gene
- Chromosome:
- 17
- Start:
- 48,591,257 bp from pter
- End:
- 48,593,961 bp from pter
- Size:
- 2,705 bases
- Orientation:
- Minus strand
Genomic View for HOXB5 Gene
Genes around HOXB5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
HOXB5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXB5 Gene
Proteins for HOXB5 Gene
-
Protein details for HOXB5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P09067-HXB5_HUMAN
- Recommended name:
- Homeobox protein Hox-B5
- Protein Accession:
- P09067
- B2RC69
- P09069
- Q17RP4
Protein attributes for HOXB5 Gene
- Size:
- 269 amino acids
- Molecular mass:
- 29434 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAA52681.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for HOXB5 Gene
Post-translational modifications for HOXB5 Gene
Other Protein References for HOXB5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXB5
-
Abcam antibodies for HOXB5
- Invitrogen Antibodies for HOXB5
- antibodies-online Antibodies for HOXB5: See all 64
- GeneTex HOXB5 antibody for HOXB5
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXB5
Protein Products
-
OriGene Purified Proteins for HOXB5
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXB5
- Origene Custom Protein Services for HOXB5
- antibodies-online Proteins for HOXB5: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXB5
-
Abcam proteins for HOXB5
Assay Products
No data available for DME Specific Peptides for HOXB5 Gene
Domains & Families for HOXB5 Gene
Gene Families for HOXB5 Gene
Protein Domains for HOXB5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXB5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P09067- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXB5 Gene
Molecular function for HOXB5 Gene
- GENATLAS Biochemistry:
- homeo box B5(2A),homologous to mouse Hox-2.1,Drosophila Scr,involved in the positioning of the mouse upper limb bud
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | IEA | -- |
| GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for HOXB5 Gene
- MGI mutant phenotypes for HOXB5:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HOXB5:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB5 gene
- Search ViGene Biosciences for HOXB5
CRISPR Products
-
OriGene CRISPR knockouts for HOXB5
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB5
- GenScript: Design CRISPR guide RNA sequences for HOXB5
miRNA for HOXB5 Gene
- miRTarBase miRNAs that target HOXB5
-
- hsa-mir-221-3p (MIRT001971)
- hsa-mir-7-5p (MIRT006902)
- hsa-mir-429 (MIRT016641)
- hsa-mir-200a-3p (MIRT020354)
- hsa-mir-200c-3p (MIRT021075)
- hsa-mir-141-3p (MIRT021658)
- hsa-mir-200b-3p (MIRT024129)
- hsa-mir-6858-5p (MIRT491441)
- hsa-mir-4689 (MIRT491442)
- hsa-mir-7106-5p (MIRT491443)
- hsa-mir-6797-5p (MIRT491444)
- hsa-mir-1249-5p (MIRT491445)
- hsa-mir-765 (MIRT491446)
- hsa-mir-6133 (MIRT491447)
- hsa-mir-6130 (MIRT491448)
- hsa-mir-6129 (MIRT491449)
- hsa-mir-6127 (MIRT491450)
- hsa-mir-4510 (MIRT491451)
- hsa-mir-4419a (MIRT491452)
- hsa-mir-4784 (MIRT491453)
- hsa-mir-4756-5p (MIRT491454)
- hsa-mir-3150b-3p (MIRT491455)
- hsa-mir-4739 (MIRT491456)
- hsa-mir-1321 (MIRT491457)
- hsa-mir-4779 (MIRT491458)
- hsa-mir-7152-5p (MIRT616089)
- hsa-mir-3074-5p (MIRT616090)
- hsa-mir-4665-5p (MIRT616091)
- hsa-mir-1275 (MIRT616092)
- hsa-mir-6783-3p (MIRT616093)
- hsa-mir-1343-3p (MIRT616094)
- hsa-mir-5010-5p (MIRT616095)
- hsa-mir-4525 (MIRT616096)
- hsa-mir-7111-5p (MIRT616097)
- hsa-mir-6870-5p (MIRT616098)
- hsa-mir-5698 (MIRT616099)
- hsa-mir-4723-5p (MIRT616100)
- hsa-mir-625-5p (MIRT616101)
- hsa-mir-637 (MIRT616102)
- hsa-mir-6742-3p (MIRT616103)
- hsa-mir-6852-5p (MIRT616104)
- hsa-mir-939-3p (MIRT616105)
- hsa-mir-6809-3p (MIRT657286)
- hsa-mir-6833-3p (MIRT657287)
- hsa-mir-4768-5p (MIRT657288)
- hsa-mir-6873-3p (MIRT657289)
- hsa-mir-514b-5p (MIRT657290)
- hsa-mir-513c-5p (MIRT657291)
- hsa-mir-4778-3p (MIRT657292)
- hsa-mir-942-5p (MIRT657293)
- hsa-mir-1236-3p (MIRT657294)
- hsa-mir-6515-3p (MIRT657295)
- hsa-mir-6817-3p (MIRT657296)
- hsa-mir-7110-3p (MIRT657297)
- hsa-mir-1304-3p (MIRT657298)
- hsa-mir-141-5p (MIRT657299)
- hsa-mir-1285-5p (MIRT657300)
- hsa-mir-216a-5p (MIRT657301)
miRNA Products
- Search ViGene Biosciences for HOXB5
Inhibitory RNA Products
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Clone Products
-
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- Addgene plasmids for HOXB5
Cell Line Products
-
Horizon Cell Lines for HOXB5
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXB5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB5 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB5 Gene
Localization for HOXB5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXB5 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HOXB5 Gene
No Data Available
Interacting Proteins for HOXB5 Gene
Selected Interacting proteins:
ENSP00000239151
P09067-HXB5_HUMAN
for HOXB5 Gene via
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009653 | anatomical structure morphogenesis | TAS | 3000607 |
No data available for Pathways by source and SIGNOR curated interactions for HOXB5 Gene
Transcripts for HOXB5 Gene
mRNA/cDNA for HOXB5 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (63) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXB5
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB5
- GenScript: Design CRISPR guide RNA sequences for HOXB5
miRNA Products
- Search ViGene Biosciences for HOXB5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB5
- Browse OriGene Inhibitory RNA Products For HOXB5
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB5 gene
Clone Products
-
OriGene ORF clones in human for HOXB5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HOXB5
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXB5
Flow Cytometry Products
Expression for HOXB5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Somite (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Lung (Respiratory System)
- Distal Mesodermal Progenitor Cells Lung Mesoderm
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Neural Tube (Nervous System)
- NULL (Uncategorized)
-
Colon (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for HOXB5 Gene
This gene is overexpressed in Colon - Transverse (x9.1), Kidney - Cortex (x6.9), Brain - Spinal cord (cervical c-1) (x5.4), and Small Intestine - Terminal Ileum (x4.1).
This gene is overexpressed in Bone (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HOXB5 Gene:
HOXB5SOURCE GeneReport for Unigene cluster for HOXB5 Gene:
Hs.654456mRNA Expression by UniProt/SwissProt for HOXB5 Gene:
P09067-HXB5_HUMAN
Tissue specificity:
Spinal cord.
Evidence on tissue expression from TISSUES for HOXB5 Gene
- Intestine(4.2)
Primer Products
-
OriGene qPCR primer pairs for HOXB5
-
OriGene qPCR primer pairs and template standards for HOXB5
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB5 Gene
Orthologs for HOXB5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXB5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXB5 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HOXB5 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxb5 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxb5 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXB5 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXB5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXB5 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXB5 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxb5 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | hoxb5-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxb5a 34 35 |
|
||
| hoxb5b 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Scr 36 |
|
|
|
| ftz 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXB5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXB5 Gene
Paralogs for HOXB5 Gene
(10) SIMAP similar genes for HOXB5 Gene using alignment to 1 proteins:
Variants for HOXB5 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000350690 | -- | 48,592,590(+) | CTACT(C/G)CAGAT | intron-variant | |
| rs1000370770 | -- | 48,593,445(+) | CTGGG(C/T)GGGCG | intron-variant, reference, missense | |
| rs1000781882 | -- | 48,594,727(+) | TCTGA(C/G)AGTTT | intron-variant, upstream-variant-2KB | |
| rs1000829001 | -- | 48,591,226(+) | GCAGA(C/G)CCCTC | intron-variant, downstream-variant-500B, upstream-variant-2KB | |
| rs1000845993 | -- | 48,592,949(+) | ACAGA(A/G)AGACC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv369n27 | CNV | loss | 19166990 |
| dgv5676n54 | CNV | loss | 21841781 |
| esv2758694 | CNV | gain | 17122850 |
| nsv833469 | CNV | loss | 17160897 |
| nsv833471 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.71;
15.03% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXB5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB5 Gene
Disorders for HOXB5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hirschsprung disease 1 |
|
|
Search HOXB5 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXB5
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB5 Gene
Publications for HOXB5 Gene
- A genome-wide association meta-analysis identifies new childhood obesity loci. (PMID: 22484627) Bradfield J.P. … Grant S.F. (Nat. Genet. 2012) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Expression of Hoxb-5 during human lung development and in congenital lung malformations. (PMID: 14632303) Volpe M.V. … Nielsen H.C. (Birth Defects Res. Part A Clin. Mol. Teratol. 2003) 3 22 64
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
- Cooperative DNA binding of the highly conserved human Hox 2.1 homeodomain gene product. (PMID: 1355360) Galang C.K. … Hauser C.A. (New Biol. 1992) 3 4 64
Products for HOXB5 Gene
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- antibodies-online Antibodies for HOXB5: See all 64
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXB5 gene
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- VectorBuilder custom plasmid, inducible vectors for HOXB5
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXB5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
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