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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB4 Gene

protein-coding   GIFtS: 53
GCID: GC17M046652

homeobox B4

(Previous name: homeo box B4 )
(Previous symbols: HOX2, HOX2F)
 Explore 14 diseases affiliated with
HOXB4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXB4    

Aliases
for HOXB4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox B41 2     Homeobox Protein Hox-2F2 3
HOX2F1 2 3 5     HOX-2.62
HOX21 2     Homeo Box 2F2
Homeo Box B41 2     Homeobox Protein Hox-B42
Homeobox Protein Hox-2.62 3     

External Ids:    HGNC: 51151   Entrez Gene: 32142   Ensembl: ENSG000001827427   OMIM: 1429655   UniProtKB: P174833   

Export aliases for HOXB4 gene to outside databases

Previous GC identifers: GC17M046364 GC17M049133 GC17M046995 GC17M047127 GC17M047128 GC17M044007 GC17M042021


Summaries
for HOXB4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXB4:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It
is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a
sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this
protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for
therapeutic stem cell expansion. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXB4_HUMAN, P17483
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB4


Genomic Views
for HOXB4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB4 gene promoter:
         E2F-4   E2F-3a   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXB4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046652:  view genomic region     (about GC identifiers)

Start:
 46,652,869 bp from pter      End:
 46,657,473 bp from pter
Size:
 4,605 bases      Orientation:
 minus strand

Proteins
for HOXB4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXB4_HUMAN, P17483 (See protein sequence)
Recommended Name: Homeobox protein Hox-B4  
Size: 251 amino acids; 27604 Da
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: Q9NTA0

Explore the universe of human proteins at neXtProt for HOXB4: NX_P17483

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17483

    • HOXB4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_076920.1  
    ENSEMBL proteins: 
     ENSP00000328928  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: HOXB4
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    Novus Biologicals HOXB4 Protein
    Novus Biologicals HOXB4 Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXB4

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--


    HOXB4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HOXB4

    Protein Domains /
    Families
    for HOXB4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXB4 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P17483

    ProtoNet protein and cluster: P17483

    1 Blocks protein family: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXB4_HUMAN, P17483
    Similarity: Belongs to the Antp homeobox family. Deformed subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXB4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXB4_HUMAN, P17483
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB4:
    homeo box B4(2F),homologous to mouse Hox-2.6,Drosophila Dfd

         Summary:  
    HOXB4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells: Blast colony cells

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB4 (see all 19):
    hsa-miR-579 hsa-miR-320a hsa-miR-3673 hsa-miR-3664-5p hsa-miR-637 hsa-miR-4274 hsa-miR-23a hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB4 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB4 (see all 7)
    OriGene shRNA RFP: HOXB4
    OriGene siRNA: HOXB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB4

    Gene Editing
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    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB4 

    Cell Line
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    Search LifeMap BioReagents cell lines for HOXB4

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity NAS--
    GO:0043565sequence-specific DNA binding IEA--


    HOXB4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for HOXB4: Hoxb4tm2Bay Hoxb4tm2Nrm Hoxb4tm1Bay Hoxb4tm2.1Nrm Hoxb4tm1Nrm Hoxb4tm1.1Karl
         11 MGI mutant phenotypes (inferred from 9 alleles) (MGI details for Hoxb4):
     cardiovascular system  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  normal  respiratory system 
     skeleton 

    HOXB4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXB4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for HOXB4 (P174833 ENSP000003289284) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    NFE2Q166213I2D: score=1 
    CUL4AENSP000003645894STRING: ENSP00000364589
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0007275multicellular organismal development NAS--


    HOXB4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXB4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXB4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB4
    2 Novoseek chemical compound relationships for HOXB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoid 37.9 1 9697850 (1)
    oligonucleotide 12.1 1 11250656 (1)

    Search CenterWatch for drugs/clinical trials and news about HOXB4 / HXB4 

    Transcripts
    for HOXB4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXB4 gene: 
    NM_024015.4  

    Unigene Cluster for HOXB4:

    Homeobox B4
    Hs.664706  [show with all ESTs]
    Unigene Representative Sequence: NM_024015
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332503(uc002inp.3)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB4
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB4 (see all 19):
    hsa-miR-579 hsa-miR-320a hsa-miR-3673 hsa-miR-3664-5p hsa-miR-637 hsa-miR-4274 hsa-miR-23a hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB4 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB4 (see all 7)
    OriGene shRNA RFP: HOXB4
    OriGene siRNA: HOXB4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB4
    Clone
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB4

    Additional cDNA sequence: 

    AL137449.1 BC049204.1 

    2 DOTS entries:

    DT.204604  DT.100022675 

    24/40 AceView cDNA sequences (see all 40):

    NM_024015 AI393199 AI683295 BX101524 AA918749 BC049204 BE904604 CR604653 
    BQ688864 BX372277 CB305868 AJ709628 BQ690790 BM972328 BU682656 BQ010103 
    AW172915 AL137449 AW182319 BQ691562 BU681896 F37859 CA444807 AI300577 

    GeneLoc Exon Structure


    Expression
    for HOXB4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGTCCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXB4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteCervical Mesenchymal SclerotomeCervical Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    BoneBone MarrowHematopoietic Stem CellsBlood
    LungLung MesodermDistal Mesodermal Progenitor CellsLung
    LungLung MesodermProximal Mesodermal Progenitor CellsLung
    KidneyMetanephrosKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Motor neuron-like cells (Motor neuron differe...)
    Neural rosettes (Spinal motor neurons...)
    N2-induced embryoid bodies (Generation of photor...)
    Neural rosettes (Generation of photor...)
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)

    See HOXB4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB4

    SOURCE GeneReport for Unigene cluster: Hs.664706
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXB4: 
              Notch Signaling Pathway in human mouse rat
              Homeobox (HOX) Genes in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB4

    Orthologs
    for HOXB4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXB4 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXB41 homeobox B4 75.49(n)
    75.78(a)    		   396230  NM_205293.1  NP_990624.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXB46
    HOXD46
    		 --
    		 65(a)
    54(a)
    		 1 ↔ 1
    possible ortholog
    		 6(75565658-75568767)
    GL343356.1(478136-480351)
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxb4a2 homeo box B4a 82.72(n)   30340  NM_131118.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dfd3 induction of apoptosis transcription factor 78(a)
    (best of 2)    		   3 84A5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-396
    		 Homeobox protein lin-39
    		 23(a)
    		 possible ortholog
    		 III(7528603-7536567)


    ENSEMBL Gene Tree for HOXB4 (if available)
    TreeFam Gene Tree for HOXB4 (if available) 

    Paralogs
    for HOXB4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB4 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  HOXA32  
    HOXD82  HOXB12  HOXB62  HOXB82  HOXD42  HOXB22  HOXB72  PDX12  
    HOXC42  
    12 SIMAP similar genes for HOXB4 using alignment to 1 protein entry:     HXB4_HUMAN:
    HOXA4    HOXB7    HOXC6    HOXB5    HOXA7    HOXC4
    HOXD4    POU6F1    PDX1    HOXA5    HOXB6    HOXD8

    HOXB4 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXB4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/68 NCBI SNPs in HOXB4 are shown (see all 68)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs38331721,2
    		C,--46653871(-) CCCCC-/CAGAAG 1 -- ut310--------
    rs345728591,2
    		C--46653872(+) GGGGG-/GCCTCC 1 -- ut310--------
    rs1839580251,2
    		--46653872(+) CTTCTA/GGGGGG 1 -- ut310--------
    rs27407551,2
    		C,--46653999(-) GGGCCC/TTGGGG 1 -- ut31 ese34Minor allele frequency- T:0.17CSA WA NA 240
    rs2022111471,2
    		--46654093(+) AGCGCA/GCGGGG 2 R syn10--------
    rs1490499231,2
    		C,--46654112(+) TGGGCC/G/TGGCCA 3 Q P R mis11NA 3412
    rs2003887381,2
    		--46654141(+) CCTGCA/CGCACC 2 A syn10--------
    rs1160583531,2
    		C,F,--46654292(+) GGTTGT/CAGTGA 2 /Y /C mis11Minor allele frequency- C:0.00NA 4550
    rs2015453811,2
    		--46654303(+) AATTCC/TTTCTC 2 K syn10--------
    rs1889523441,2
    		--46654312(+) TCCAGA/CTCCAA 2 E D mis10--------

    HapMap Linkage Disequilibrium report for HOXB4 (46652869 - 46657473 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for HOXB4
         2 CNVs: 53230 4040
         1 Indel: 58797

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for HOXB4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXB4 for disorders           About GeneDecksing

    OMIM gene information: 142965    OMIM disorders: --

    14 diseases for HOXB4:    About MalaCards
    severe combined immunodeficiency    myeloid leukemia    acute myeloid leukemia    combined immunodeficiency
    leukemia    cervical carcinoma    hematopoiesis    cervicitis
    lung cancer    neuroblastoma    immunodeficiency    carcinoma
    pancreatitis    lymphoid leukemia

    3 Novoseek disease relationships for HOXB4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 44.1 2 18357342 (1)
    leukemia 32.8 5 18357342 (1), 18357348 (1), 15226173 (1), 15580301 (1)
    cancer 0 1 20379445 (1)


    Export disorders for HOXB4 gene to outside databases

    Publications
    for HOXB4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB4 gene, integrated from 9 sources (see all 92):
    (articles sorted by number of sources associating them with HOXB4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. (PubMed id 11085749)1, 2, 9 Giannola D.M.... Emerson S.G. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    4. Expression of HOX homeogenes in human neuroblastoma cell culture lines. (PubMed id 1981366)1, 2 Peverali F.A.... Boncinelli E. (1990)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    6. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    7. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
    8. [Analysis on promoter CpG methylation and expression of HOXB4 gene in cord blood CD34(+) cells and peripheral blood mononuclear cell s] (PubMed id 19549386)1, 9 Zheng C.L....Lu M. (2009)
    9. High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. (PubMed id 12406897)1, 9 Schiedlmeier B....Ostertag W. (2003)
    10. Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression. (PubMed id 11250656)1, 9 Pan Q. and Simpson R.U. (2001)

    External Searches for HOXB4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing HOXB4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3214 HGNC: 5115 AceView: HOXB4 Ensembl:ENSG00000182742 euGenes: HUgn3214
    ECgene: HOXB4 H-InvDB: HOXB4

    Other Databases showing HOXB4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXB4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB4 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXB4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXB4 gene:
    Search GeneIP for patents involving HOXB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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