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Aliases for HOXB4 Gene

Aliases for HOXB4 Gene

  • Homeobox B4 2 3 5
  • Homeobox Protein Hox-2.6 3 4
  • Homeobox Protein Hox-2F 3 4
  • Homeo Box B4 2 3
  • HOX2F 3 4
  • Homeobox Protein Hox-B4 3
  • Homeo Box 2F 3
  • HOX-2.6 3
  • HOX2 3

External Ids for HOXB4 Gene

Previous HGNC Symbols for HOXB4 Gene

  • HOX2
  • HOX2F

Previous GeneCards Identifiers for HOXB4 Gene

  • GC17M046364
  • GC17M049133
  • GC17M046995
  • GC17M047127
  • GC17M047128
  • GC17M044007
  • GC17M046652
  • GC17M042021

Summaries for HOXB4 Gene

Entrez Gene Summary for HOXB4 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB4 Gene

HOXB4 (Homeobox B4) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXC4.

UniProtKB/Swiss-Prot for HOXB4 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB4 Gene

Genomics for HOXB4 Gene

Regulatory Elements for HOXB4 Gene

Enhancers for HOXB4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F048496 1.5 Ensembl ENCODE 12.1 +82.0 81957 2.8 KLF1 ESRRA INSM2 KLF17 HIC1 CTBP1 ZNF600 FOS KLF8 EGR2 HOXB2 SKAP1 ENSG00000266601 HOXB-AS1 HOXB4 MIR10A HOXB3 HOXB1 HOXB-AS2 HOXB-AS3
GH17F048491 0.9 FANTOM5 Ensembl ENCODE 12.1 +87.5 87461 2.1 PKNOX1 CREB3L1 FEZF1 ZNF2 ZNF143 ZNF548 ZNF263 REST MEF2D ZNF610 HOXB2 SKAP1 RN7SL125P GIP LOC105371815 ENSG00000251461 ENSG00000264243 LINC02075 HOXB4 MIR10A
GH17F048494 0.2 ENCODE 12.1 +85.5 85528 1.0 ZNF645 PRDM2 ZNF664 ZSCAN16 ZBTB48 ZNF580 ZNF524 FOS ZNF600 ZNF24 HOXB2 SKAP1 RN7SL125P GIP ENSG00000251461 LOC105371815 ENSG00000264243 LINC02075 HOXB4 MIR10A
GH17F048505 1.1 FANTOM5 Ensembl ENCODE 11.8 +74.1 74068 1.8 HDAC1 PKNOX1 BMI1 RAD21 ZNF366 RCOR1 FOS USF2 CEBPB JUNB HOXB2 SKAP1 HOXB-AS1 HOXB1 HOXB4 MIR10A HOXB3 HOXB-AS3 HOXB-AS2 LOC105371808
GH17F048503 0.6 ENCODE 11.8 +76.3 76257 1.6 ZNF263 ZMYM3 ZBTB8A ZIC2 OSR2 ZFHX2 GATA3 GLIS1 ZNF341 TRIM28 HOXB2 SKAP1 HOXB-AS1 HOXB1 HOXB4 MIR10A HOXB3 HOXB-AS3 HOXB-AS2 MIR1203
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HOXB4 on UCSC Golden Path with GeneCards custom track

Promoters for HOXB4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001348218 1711 4001 PKNOX1 CREB3L1 FEZF1 ZNF2 ZNF263 SP3 REST CBX8 ZNF610 SMARCA4
ENSR00001807832 -1889 1601 TBP ARNT FEZF1 SCRT2 NCOA1 REST NR2F2 POLR2H CBX8 SMARCA4

Genomic Location for HOXB4 Gene

Chromosome:
17
Start:
48,575,507 bp from pter
End:
48,580,111 bp from pter
Size:
4,605 bases
Orientation:
Minus strand

Genomic View for HOXB4 Gene

Genes around HOXB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB4 Gene

Proteins for HOXB4 Gene

  • Protein details for HOXB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17483-HXB4_HUMAN
    Recommended name:
    Homeobox protein Hox-B4
    Protein Accession:
    P17483
    Secondary Accessions:
    • Q9NTA0

    Protein attributes for HOXB4 Gene

    Size:
    251 amino acids
    Molecular mass:
    27604 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXB4 Gene

Post-translational modifications for HOXB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXB4 Gene

Domains & Families for HOXB4 Gene

Gene Families for HOXB4 Gene

Suggested Antigen Peptide Sequences for HOXB4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17483

UniProtKB/Swiss-Prot:

HXB4_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family. Deformed subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family. Deformed subfamily.
genes like me logo Genes that share domains with HOXB4: view

Function for HOXB4 Gene

Molecular function for HOXB4 Gene

GENATLAS Biochemistry:
homeo box B4(2F),homologous to mouse Hox-2.6,Drosophila Dfd
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

LifeMap Function Summary for HOXB4 Gene

HOXB4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB4: view
genes like me logo Genes that share phenotypes with HOXB4: view

Animal Models for HOXB4 Gene

MGI Knock Outs for HOXB4:

Animal Model Products

miRNA for HOXB4 Gene

miRTarBase miRNAs that target HOXB4
Targeted motifs for HOXB4 Gene
HOMER Transcription Factor Regulatory Elements motif HOXB4
  • Consensus sequence: TGATTRATGGCY Submotif: canonical Cell Type: ES GEO ID: GSE34014

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXB4

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HOXB4 Gene

Localization for HOXB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB4 Gene COMPARTMENTS Subcellular localization image for HOXB4 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXB4: view

Pathways & Interactions for HOXB4 Gene

genes like me logo Genes that share pathways with HOXB4: view

Gene Ontology (GO) - Biological Process for HOXB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0002011 morphogenesis of an epithelial sheet IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with HOXB4: view

No data available for SIGNOR curated interactions for HOXB4 Gene

Drugs & Compounds for HOXB4 Gene

(2) Additional Compounds for HOXB4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HOXB4: view

Transcripts for HOXB4 Gene

mRNA/cDNA for HOXB4 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXB4 Gene

Homeobox B4:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXB4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB4 Gene

No ASD Table

Relevant External Links for HOXB4 Gene

GeneLoc Exon Structure for
HOXB4
ECgene alternative splicing isoforms for
HOXB4

Expression for HOXB4 Gene

mRNA expression in normal human tissues for HOXB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB4 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (x4.8) and Colon - Sigmoid (x4.2).

Protein differential expression in normal tissues from HIPED for HOXB4 Gene

This gene is overexpressed in Nasal epithelium (42.4) and Tlymphocyte (16.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXB4 Gene



NURSA nuclear receptor signaling pathways regulating expression of HOXB4 Gene:

HOXB4

SOURCE GeneReport for Unigene cluster for HOXB4 Gene:

Hs.664706
genes like me logo Genes that share expression patterns with HOXB4: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for HOXB4 Gene

Orthologs for HOXB4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXB4 34 35
  • 99.87 (n)
cow
(Bos Taurus)
Mammalia HOXB4 34 35
  • 96.94 (n)
mouse
(Mus musculus)
Mammalia Hoxb4 34 16 35
  • 95.32 (n)
rat
(Rattus norvegicus)
Mammalia Hoxb4 34
  • 94.3 (n)
dog
(Canis familiaris)
Mammalia HOXB4 34 35
  • 93.33 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXB4 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB4 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB4 34
  • 74.5 (n)
lizard
(Anolis carolinensis)
Reptilia HOXB4 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb4 34
  • 66.83 (n)
zebrafish
(Danio rerio)
Actinopterygii hoxb4a 34 35
  • 69.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dfd 36 35
  • 78 (a)
Scr 36
  • 72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
OneToMany
Species where no ortholog for HOXB4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB4 Gene

ENSEMBL:
Gene Tree for HOXB4 (if available)
TreeFam:
Gene Tree for HOXB4 (if available)

Paralogs for HOXB4 Gene

(11) SIMAP similar genes for HOXB4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXB4: view

Variants for HOXB4 Gene

Sequence variations from dbSNP and Humsavar for HOXB4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10599517 -- 48,575,719(+) GCAAC(-/ATA)ATAAA intron-variant, upstream-variant-2KB, cds-indel
rs112086611 -- 48,578,862(+) GCGGG(G/T)TGGGG intron-variant, upstream-variant-2KB
rs11301183 -- 48,575,676(+) AAAAA(-/T)AGTAA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs114063085 -- 48,575,453(+) TATAC(A/G)CTGGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs114420588 -- 48,576,240(+) AGGCG(A/C/G)AGGCG intron-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXB4 Gene

Variant ID Type Subtype PubMed ID
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv1007307 CNV deletion 20482838
esv2758694 CNV gain 17122850
nsv819832 CNV gain 19587683
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897

Variation tolerance for HOXB4 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB4 Gene

Disorders for HOXB4 Gene

Relevant External Links for HOXB4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB4

No disorders were found for HOXB4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB4 Gene

Publications for HOXB4 Gene

  1. Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. (PMID: 11085749) Giannola D.M. … Emerson S.G. (J. Exp. Med. 2000) 3 4 22 64
  2. Generation of mesenchymal stromal cells from HOXB4-expressing human embryonic stem cells. (PMID: 19878058) Liu Y.P. … Hematti P. (Cytotherapy 2009) 3 22 64
  3. [Analysis on promoter CpG methylation and expression of HOXB4 gene in cord blood CD34(+) cells and peripheral blood mononuclear cells]. (PMID: 19549386) Zheng C.L. … Lu M. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 3 22 64
  4. The HOXB4 homeoprotein differentially promotes ex vivo expansion of early human lymphoid progenitors. (PMID: 17962697) Haddad R. … Amsellem S. (Stem Cells 2008) 3 22 64
  5. Effects of HOXB4 overexpression on ex vivo expansion and immortalization of hematopoietic cells from different species. (PMID: 17510218) Zhang X.B. … Kiem H.P. (Stem Cells 2007) 3 22 64

Products for HOXB4 Gene

Sources for HOXB4 Gene

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