Aliases for HOXB4 Gene
Aliases for HOXB4 Gene
External Ids for HOXB4 Gene
- HGNC: 5115
- Entrez Gene: 3214
- Ensembl: ENSG00000182742
- OMIM: 142965
- UniProtKB: P17483
Previous HGNC Symbols for HOXB4 Gene
- HOX2
- HOX2F
Previous GeneCards Identifiers for HOXB4 Gene
- GC17M046364
- GC17M049133
- GC17M046995
- GC17M047127
- GC17M047128
- GC17M044007
- GC17M046652
- GC17M042021
Summaries for HOXB4 Gene
-
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB4 Gene
HOXB4 (Homeobox B4) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXC4.
UniProtKB/Swiss-Prot for HOXB4 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB4 Gene
Genomics for HOXB4 Gene
Regulatory Elements for HOXB4 Gene
Enhancers for HOXB4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXB4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXB4 gene promoter:
Regulatory Element Products
Genomic Location for HOXB4 Gene
- Chromosome:
- 17
- Start:
- 48,575,507 bp from pter
- End:
- 48,580,111 bp from pter
- Size:
- 4,605 bases
- Orientation:
- Minus strand
Genomic View for HOXB4 Gene
Genes around HOXB4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
HOXB4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXB4 Gene
Proteins for HOXB4 Gene
-
Protein details for HOXB4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P17483-HXB4_HUMAN
- Recommended name:
- Homeobox protein Hox-B4
- Protein Accession:
- P17483
- Q9NTA0
Protein attributes for HOXB4 Gene
- Size:
- 251 amino acids
- Molecular mass:
- 27604 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXB4 Gene
Post-translational modifications for HOXB4 Gene
Other Protein References for HOXB4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HOXB4
- Novus Biologicals Antibodies for HOXB4
- Invitrogen Antibodies for HOXB4
- antibodies-online Antibodies for HOXB4: See all 72
- GeneTex HOXB4 antibody for HOXB4
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXB4
Protein Products
-
OriGene Purified Proteins for HOXB4
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXB4
- Origene Custom Protein Services for HOXB4
- antibodies-online Proteins for HOXB4: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXB4
-
ProSci Proteins for HOXB4
Assay Products
- antibodies-online Kits for HOXB4: See all 1
No data available for DME Specific Peptides for HOXB4 Gene
Domains & Families for HOXB4 Gene
Gene Families for HOXB4 Gene
Protein Domains for HOXB4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXB4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P17483- Family:
-
- Belongs to the Antp homeobox family. Deformed subfamily.
Function for HOXB4 Gene
Molecular function for HOXB4 Gene
- GENATLAS Biochemistry:
- homeo box B4(2F),homologous to mouse Hox-2.6,Drosophila Dfd
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
LifeMap Function Summary for HOXB4 Gene
HOXB4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
-
and also in
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXB4 Gene
- MGI mutant phenotypes for HOXB4:
- inferred from 9 alleles
- GenomeRNAi human phenotypes for HOXB4:
Animal Models for HOXB4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB4 gene
- Search ViGene Biosciences for HOXB4
CRISPR Products
-
OriGene CRISPR knockouts for HOXB4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB4
- GenScript: Design CRISPR guide RNA sequences for HOXB4
miRNA for HOXB4 Gene
- miRTarBase miRNAs that target HOXB4
Targeted motifs for HOXB4 Gene
HOMER Transcription Factor Regulatory Elements motif HOXB4
- Consensus sequence: TGATTRATGGCY Submotif: canonical Cell Type: ES GEO ID: GSE34014
miRNA Products
- Search ViGene Biosciences for HOXB4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB4
- Browse OriGene Inhibitory RNA Products For HOXB4
- Search ViGene Biosciences for HOXB4
Clone Products
-
OriGene ORF clones in human for HOXB4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXB4
Cell Line Products
-
Horizon Cell Lines for HOXB4
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXB4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB4 gene
- Search ViGene Biosciences for HOXB4
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HOXB4 Gene
Localization for HOXB4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXB4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 4 |
| plasma membrane | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005813 | centrosome | IDA | -- |
Pathways & Interactions for HOXB4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for HOXB4 Gene
Interacting Proteins for HOXB4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0002011 | morphogenesis of an epithelial sheet | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for HOXB4 Gene
Transcripts for HOXB4 Gene
mRNA/cDNA for HOXB4 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (40) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXB4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB4
- GenScript: Design CRISPR guide RNA sequences for HOXB4
miRNA Products
- Search ViGene Biosciences for HOXB4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXB4
- Browse OriGene Inhibitory RNA Products For HOXB4
- Search ViGene Biosciences for HOXB4
Clone Products
-
OriGene ORF clones in human for HOXB4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXB4
Flow Cytometry Products
Expression for HOXB4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Outer Root Sheath Progenitor Cells Embryonic Epidermis
-
Lung (Respiratory System)
- Proximal Mesodermal Progenitor Cells Lung Mesoderm
- Distal Mesodermal Progenitor Cells Lung Mesoderm
- Brain (Nervous System)
- Motor Neurons (Nervous System)
- Spinal Cord (Nervous System)
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
-
Somite (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Bone (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Epidermis (Integumentary System)
- Outer Root Sheath Progenitor Cells Embryonic Epidermis
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Neural Tube (Nervous System)
- Kidney (Urinary System)
- Astrocytes (Nervous System)
- Glial Cells
- NULL (Uncategorized)
- Neurons
- Neural Ectoderm (Nervous System)
mRNA differential expression in normal tissues according to GTEx for HOXB4 Gene
This gene is overexpressed in Esophagus - Gastroesophageal Junction (x4.8) and Colon - Sigmoid (x4.2).
This gene is overexpressed in Nasal epithelium (42.4) and Tlymphocyte (16.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXB4 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXB4 Gene:
HOXB4SOURCE GeneReport for Unigene cluster for HOXB4 Gene:
Hs.664706Evidence on tissue expression from TISSUES for HOXB4 Gene
- Bone marrow(2.3)
Primer Products
-
OriGene qPCR primer pairs for HOXB4
-
OriGene qPCR primer pairs and template standards for HOXB4
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB4 Gene
Orthologs for HOXB4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXB4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXB4 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxb4 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxb4 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXB4 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXB4 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXB4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXB4 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXB4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxb4 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxb4a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dfd 36 35 |
|
||
| Scr 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXB4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXB4 Gene
Paralogs for HOXB4 Gene
(11) SIMAP similar genes for HOXB4 Gene using alignment to 1 proteins:
Variants for HOXB4 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000181354 | -- | 48,575,888(+) | TCACC(C/G)TGCCA | intron-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs1000232979 | -- | 48,580,132(+) | TTCAA(A/G)TAGCC | intron-variant, upstream-variant-2KB | |
| rs1001024298 | -- | 48,575,550(+) | ACTCT(C/G)TACAG | intron-variant, upstream-variant-2KB, utr-variant-3-prime | |
| rs1001149074 | -- | 48,575,205(+) | TCTTG(C/T)GTCCT | intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime | |
| rs1001458729 | -- | 48,579,777(+) | AGACT(G/T)TCCTC | intron-variant, downstream-variant-500B, upstream-variant-2KB |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv369n27 | CNV | loss | 19166990 |
| dgv5676n54 | CNV | loss | 21841781 |
| esv1007307 | CNV | deletion | 20482838 |
| esv2758694 | CNV | gain | 17122850 |
| nsv819832 | CNV | gain | 19587683 |
| nsv833469 | CNV | loss | 17160897 |
| nsv833471 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.28;
25.59% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXB4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXB4
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB4 Gene
Disorders for HOXB4 Gene
Relevant External Links for HOXB4
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HOXB4
No disorders were found for HOXB4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXB4 Gene
Publications for HOXB4 Gene
- Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. (PMID: 11085749) Giannola D.M. … Emerson S.G. (J. Exp. Med. 2000) 3 4 22 64
- [Analysis on promoter CpG methylation and expression of HOXB4 gene in cord blood CD34(+) cells and peripheral blood mononuclear cells]. (PMID: 19549386) Zheng C.L. … Lu M. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 3 22 64
- Generation of mesenchymal stromal cells from HOXB4-expressing human embryonic stem cells. (PMID: 19878058) Liu Y.P. … Hematti P. (Cytotherapy 2009) 3 22 64
- The HOXB4 homeoprotein differentially promotes ex vivo expansion of early human lymphoid progenitors. (PMID: 17962697) Haddad R. … Amsellem S. (Stem Cells 2008) 3 22 64
- Effects of HOXB4 overexpression on ex vivo expansion and immortalization of hematopoietic cells from different species. (PMID: 17510218) Zhang X.B. … Kiem H.P. (Stem Cells 2007) 3 22 64
Products for HOXB4 Gene
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- OriGene qPCR primer pairs and template standards for HOXB4
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- Addgene plasmids for HOXB4
- antibodies-online Antibodies for HOXB4: See all 72
- antibodies-online Kits for HOXB4: See all 1
- antibodies-online Proteins for HOXB4: See all 6
- Search antibodies-online for peptides
- GeneTex HOXB4 antibody for HOXB4
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXB4 gene
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- Santa Cruz Biotechnology (SCBT) Antibodies for HOXB4
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- VectorBuilder custom plasmid, inducible vectors for HOXB4
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXB4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
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- (98) BioGPS
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- (100) COMPARTMENTS
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