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HOXB4 Gene

protein-coding   GIFtS: 53
GCID: GC17M046652

Homeobox B4

(Previous name: homeo box B4)
(Previous symbols: HOX2, HOX2F)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox B41 2     Homeobox Protein Hox-2F2 3
HOX2F1 2 3 5     HOX-2.62
HOX21 2     Homeo Box 2F2
Homeo Box B41 2     Homeobox Protein Hox-B42
Homeobox Protein Hox-2.62 3     

External Ids:    HGNC: 51151   Entrez Gene: 32142   Ensembl: ENSG000001827427   OMIM: 1429655   UniProtKB: P174833   

Export aliases for HOXB4 gene to outside databases

Previous GC identifers: GC17M046364 GC17M049133 GC17M046995 GC17M047127 GC17M047128 GC17M044007 GC17M042021


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXB4 Gene:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding
domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions
as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression
of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential
candidate for therapeutic stem cell expansion. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB4 Gene:
HOXB4 (homeobox B4) is a protein-coding gene. Diseases associated with HOXB4 include lymphoid leukemia, and cytomegalovirus infection. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot: HXB4_HUMAN, P17483
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXB4 gene promoter:
         E2F-4   E2F-3a   AP-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB4 promoter sequence
   Search Chromatin IP Primers for HOXB4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXB4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046652:  view genomic region     (about GC identifiers)

Start:
46,652,869 bp from pter      End:
46,657,473 bp from pter
Size:
4,605 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXB4_HUMAN, P17483 (See protein sequence)
Recommended Name: Homeobox protein Hox-B4  
Size: 251 amino acids; 27604 Da
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: Q9NTA0

Explore the universe of human proteins at neXtProt for HOXB4: NX_P17483

Explore proteomics data for HOXB4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXB4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_076920.1  
    ENSEMBL proteins: 
     ENSP00000328928  

    HOXB4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HOXB4

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    HOXB4 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry P17483

    ProtoNet protein and cluster: P17483

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXB4_HUMAN, P17483
    Similarity: Belongs to the Antp homeobox family. Deformed subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXB4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB4_HUMAN, P17483
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB4:
    homeo box B4(2F),homologous to mouse Hox-2.6,Drosophila Dfd

         Summary: 
    HOXB4 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
                
    Blood: Blast colony cells, Blast colony cells

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXB4 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Hoxb4):
     cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  mortality/aging  muscle  normal  respiratory system 
     skeleton 

    HOXB4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXB4: Hoxb4tm2Bay Hoxb4tm2Nrm Hoxb4tm1Bay Hoxb4tm2.1Nrm Hoxb4tm1Nrm Hoxb4tm1.1Karl

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXB4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXB4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXB4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXB4

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  TGATTRATGGCY 

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXB4:
    hsa-let-7a-5p (MIRT052567)

    Block miRNA regulation of human, mouse, rat HOXB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXB4 (see all 19):
    hsa-miR-579 hsa-miR-320a hsa-miR-3673 hsa-miR-3664-5p hsa-miR-637 hsa-miR-4274 hsa-miR-23a hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidHOXB4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXB4
    Predesigned siRNA for gene silencing in human, mouse, rat HOXB4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HOXB4

    Clone
    Products:
         
    OriGene clones in human, mouse for HOXB4 (see all 6)
    OriGene ORF clones in mouse, rat for HOXB4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXB4 (NM_024015)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HOXB4
    Browse ESI BIO Cell Lines and PureStem Progenitors for HOXB4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXB4_HUMAN, P17483: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXB4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXB4: 
              Notch Signaling Pathway in human mouse rat
              Homeobox (HOX) Genes in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HOXB4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HOXB4 (P174833 ENSP000003289284) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    NFE2Q166213I2D: score=1 
    CUL4AENSP000003645894STRING: ENSP00000364589
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development ----

    HOXB4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXB4 (HXB4)

    2 Novoseek inferred chemical compound relationships for HOXB4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoid 37.9 1 9697850 (1)
    oligonucleotide 12.1 1 11250656 (1)



    HOXB4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOXB4 gene: 
    NM_024015.4  

    Unigene Cluster for HOXB4:

    Homeobox B4
    Hs.664706  [show with all ESTs]
    Unigene Representative Sequence: NM_024015
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000332503(uc002inp.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXB4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXB4 (see all 19):
    hsa-miR-579 hsa-miR-320a hsa-miR-3673 hsa-miR-3664-5p hsa-miR-637 hsa-miR-4274 hsa-miR-23a hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidHOXB4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXB4
    Predesigned siRNA for gene silencing in human, mouse, rat HOXB4
    Clone
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    OriGene ORF clones in mouse, rat for HOXB4
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    GenScript: all cDNA clones in your preferred vector: HOXB4 (NM_024015)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB4
    Primer
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    OriGene qPCR primer pairs and template standards for HOXB4
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXB4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB4
      QuantiTect SYBR Green Assays in human, mouse, rat HOXB4
      QuantiFast Probe-based Assays in human, mouse, rat HOXB4

    Additional mRNA sequence: 

    AL137449.1 BC049204.1 

    2 DOTS entries:

    DT.204604  DT.100022675 

    Selected AceView cDNA sequences (see all 40):

    CR604653 AI683295 AI393199 NM_024015 BC049204 AA918749 BQ688864 BX101524 
    BE904604 AI300577 AW172915 CB305868 BX372277 AJ709628 BU682656 BQ010103 
    BQ691562 BU681896 CA444807 AW182319 AL137449 BQ690790 F37859 BM972328 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXB4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGTCCTCT
    HOXB4 Expression
    About this image


    HOXB4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Motor Neurons (Nervous System)    fully expand to see all 2 entries
             Motor neuron-like cells
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Motor neuron-like cells
     
     Cartilage (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Somite (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Neurons
             Motor neuron-like cells
    HOXB4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXB4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.664706
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXB4: 
              Notch Signaling Pathway in human mouse rat
              Homeobox (HOX) Genes in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HOXB4
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    QuantiFast Probe-based Assays in human, mouse, rat HOXB4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOXB4 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxb41 , 5 homeobox B41, 5 95.32(n)1
    96.93(a)1
      11 (59.83 cM)5
    154121  NM_010459.71  NP_034589.31 
     963166845 
    chicken
    (Gallus gallus)
    Aves HOXB41 homeobox B4 74.5(n)
    73.73(a)
      396230  NM_205293.1  NP_990624.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXB46
    homeobox B4
    65(a)
    1 ↔ 1
    6(75565658-75568767)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hoxb41 homeobox B4 66.83(n)
    65.37(a)
      548393  NM_001123015.1  NP_001116487.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxb4a2 homeo box B4a 82.72(n)   30340  NM_131118.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dfd3 induction of apoptosis transcription
    factor
    78(a)
    (best of 2)
      3 84A5   --


    ENSEMBL Gene Tree for HOXB4 (if available)
    TreeFam Gene Tree for HOXB4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXB4 gene
    HOXA72  HOXB52  HOXC62  HOXC52  HOXA52  ENSG000002732662  HOXA42  HOXC82  
    HOXA62  ENSG000002730492  HOXD82  HOXB62  HOXB82  HOXD42  HOXB72  HOXC42  
    11 SIMAP similar genes for HOXB4 using alignment to 1 protein entry:     HXB4_HUMAN:
    HOXA4    HOXB7    HOXC6    HOXB5    HOXA7    HOXC4
    HOXD4    POU6F1    PDX1    HOXA5    HOXB6

    HOXB4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXB4 (see all 80)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs38331721,2
    C--46653871(-) CCCCC-/CAGAAG 1 -- ut310--------
    rs1839580251,2
    C--46653872(+) CTTCTA/GGGGGG 1 -- ut310--------
    rs27407551,2
    C--46653999(-) GGGCCC/TTGGGG 1 -- ut31 ese34Minor allele frequency- T:0.17CSA WA NA 240
    rs2022111471,2
    C--46654093(+) AGCGCA/GCGGGG 2 R syn10--------
    rs1490499231,2
    --46654112(+) TGGGCC/GGGCCA 2 P R mis10--------
    rs2003887381,2
    --46654141(+) CCTGCA/CGCACC 2 A syn10--------
    rs1160583531,2
    C,F--46654292(+) GGTTGT/CAGTGA 2 /Y /C mis11Minor allele frequency- C:0.00NA 4550
    rs2015453811,2
    --46654303(+) AATTCC/TTTCTC 2 K syn10--------
    rs1889523441,2
    --46654312(+) TCCAGA/CTCCAA 2 E D mis10--------
    rs37447761,2
    C,F,H--46654430(-) TCTTTC/TGGGGG 1 -- int116Minor allele frequency- T:0.15EA NS WA NA 3828

    HapMap Linkage Disequilibrium report for HOXB4 (46652869 - 46657473 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for HOXB4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1007307CNV Deletion20482838
    dgv3223n71CNV Loss21882294
    dgv369n27CNV Loss19166990
    dgv3224n71CNV Loss21882294
    nsv833469CNV Loss17160897
    dgv3222n71CNV Loss21882294
    nsv833471CNV Gain17160897
    nsv819832CNV Gain19587683
    dgv988e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142965    OMIM disorders: --

    15 diseases for HOXB4:    
    About MalaCards
    lymphoid leukemia    cytomegalovirus infection    omphalocele    severe combined immunodeficiency
    acute myeloid leukemia    myeloid leukemia    acute leukemia    cervicitis
    cervical cancer    neuroblastoma    leukemia    lung cancer
    retinitis    pancreatitis    neuronitis


    HOXB4 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for HOXB4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia 44.1 2 18357342 (1)
    leukemia 32.8 5 18357342 (1), 18357348 (1), 15226173 (1), 15580301 (1)
    cancer 0 1 20379445 (1)


    Export disorders for HOXB4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXB4 gene, integrated from 10 sources (see all 95):
    (articles sorted by number of sources associating them with HOXB4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2. (PubMed id 11085749)1, 2, 9 Giannola D.M.... Emerson S.G. (J. Exp. Med. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    4. Expression of HOX homeogenes in human neuroblastoma cell culture lines. (PubMed id 1981366)1, 2 Peverali F.A.... Boncinelli E. (Differentiation 1990)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    6. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
    7. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (Differentiation 1989)
    8. [Analysis on promoter CpG methylation and expression of HOXB4 gene in cord blood CD34(+) cells and peripheral blood mononuclear cells]. (PubMed id 19549386)1, 9 Zheng C.L....Lu M. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009)
    9. High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation. (PubMed id 12406897)1, 9 Schiedlmeier B....Ostertag W. (Blood 2003)
    10. Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression. (PubMed id 11250656)1, 9 Pan Q. and Simpson R.U. (J. Endocrinol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3214 HGNC: 5115 AceView: HOXB4 Ensembl:ENSG00000182742 euGenes: HUgn3214
    ECgene: HOXB4 H-InvDB: HOXB4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXB4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXB4 gene:
    Search GeneIP for patents involving HOXB4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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