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Aliases for HOXB3 Gene

Aliases for HOXB3 Gene

  • Homeobox B3 2 3 5
  • Homeobox Protein Hox-2.7 3 4
  • Homeobox Protein Hox-2G 3 4
  • HOX2G 3 4
  • Homeobox Protein Hox-B3 3
  • Homeo Box B3 2
  • Homeo Box 2G 3
  • Hox-2.7 3
  • HOX2 3

External Ids for HOXB3 Gene

Previous HGNC Symbols for HOXB3 Gene

  • HOX2
  • HOX2G

Previous GeneCards Identifiers for HOXB3 Gene

  • GC17M046338
  • GC17M049107
  • GC17M046969
  • GC17M047101
  • GC17M043983
  • GC17M046626
  • GC17M041996

Summaries for HOXB3 Gene

Entrez Gene Summary for HOXB3 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML). [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB3 Gene

HOXB3 (Homeobox B3) is a Protein Coding gene. Diseases associated with HOXB3 include Leukemia, Acute Myeloid. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is HOXA3.

UniProtKB/Swiss-Prot for HOXB3 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB3 Gene

Genomics for HOXB3 Gene

Regulatory Elements for HOXB3 Gene

Enhancers for HOXB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around HOXB3 on UCSC Golden Path with GeneCards custom track

Promoters for HOXB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HOXB3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXB3 Gene

Chromosome:
17
Start:
48,548,870 bp from pter
End:
48,604,912 bp from pter
Size:
56,043 bases
Orientation:
Minus strand

Genomic View for HOXB3 Gene

Genes around HOXB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB3 Gene

Proteins for HOXB3 Gene

  • Protein details for HOXB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14651-HXB3_HUMAN
    Recommended name:
    Homeobox protein Hox-B3
    Protein Accession:
    P14651
    Secondary Accessions:
    • A8K567
    • B7Z5N8
    • B7Z5P8
    • B7ZAD0
    • D3DTV3
    • O95615
    • P17484

    Protein attributes for HOXB3 Gene

    Size:
    431 amino acids
    Molecular mass:
    44340 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HOXB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOXB3 Gene

Post-translational modifications for HOXB3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HOXB3 Gene

Domains & Families for HOXB3 Gene

Gene Families for HOXB3 Gene

Graphical View of Domain Structure for InterPro Entry

P14651

UniProtKB/Swiss-Prot:

HXB3_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXB3: view

Function for HOXB3 Gene

Molecular function for HOXB3 Gene

GENATLAS Biochemistry:
homeo box B3(2G),homologous to mouse Hox-2.7,Drosophila Zen
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB3: view
genes like me logo Genes that share phenotypes with HOXB3: view

Animal Models for HOXB3 Gene

MGI Knock Outs for HOXB3:

Animal Model Products

CRISPR Products

miRNA for HOXB3 Gene

miRTarBase miRNAs that target HOXB3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB3 Gene

Localization for HOXB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB3 Gene COMPARTMENTS Subcellular localization image for HOXB3 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXB3: view

Pathways & Interactions for HOXB3 Gene

genes like me logo Genes that share pathways with HOXB3: view

Gene Ontology (GO) - Biological Process for HOXB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IEP 17972163
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXB3: view

No data available for SIGNOR curated interactions for HOXB3 Gene

Drugs & Compounds for HOXB3 Gene

No Compound Related Data Available

Transcripts for HOXB3 Gene

Unigene Clusters for HOXB3 Gene

Homeobox B3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB3 Gene

No ASD Table

Relevant External Links for HOXB3 Gene

GeneLoc Exon Structure for
HOXB3
ECgene alternative splicing isoforms for
HOXB3

Expression for HOXB3 Gene

mRNA expression in normal human tissues for HOXB3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB3 Gene

This gene is overexpressed in Colon - Sigmoid (x4.2) and Esophagus - Gastroesophageal Junction (x4.2).

Protein differential expression in normal tissues from HIPED for HOXB3 Gene

This gene is overexpressed in Brain (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB3 Gene



Protein tissue co-expression partners for HOXB3 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOXB3 Gene:

HOXB3

SOURCE GeneReport for Unigene cluster for HOXB3 Gene:

Hs.654560
genes like me logo Genes that share expression patterns with HOXB3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HOXB3 Gene

Orthologs for HOXB3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXB3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXB3 34
  • 92.33 (n)
  • 95.07 (a)
HOXB3 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXB3 34
  • 94.04 (n)
  • 96.75 (a)
HOXB3 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb3 34
  • 91.09 (n)
  • 95.35 (a)
Hoxb3 16
Hoxb3 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXB3 34
  • 99.69 (n)
  • 99.54 (a)
HOXB3 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb3 34
  • 90.91 (n)
  • 95.1 (a)
oppossum
(Monodelphis domestica)
Mammalia HOXB3 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB3 34
  • 71.27 (n)
  • 71.36 (a)
HOXB3 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXB3 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb3 34
  • 69.61 (n)
  • 67.53 (a)
Str.15450 34
zebrafish
(Danio rerio)
Actinopterygii hoxb3a 34
  • 68.41 (n)
  • 71.89 (a)
hoxb3a 35
  • 69 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for HOXB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB3 Gene

ENSEMBL:
Gene Tree for HOXB3 (if available)
TreeFam:
Gene Tree for HOXB3 (if available)

Paralogs for HOXB3 Gene

Paralogs for HOXB3 Gene

(11) SIMAP similar genes for HOXB3 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for HOXB3 Gene

genes like me logo Genes that share paralogs with HOXB3: view

Variants for HOXB3 Gene

Sequence variations from dbSNP and Humsavar for HOXB3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2229304 - 48,552,231(-) CCGAG(A/C)CCCTG intron-variant, reference, missense
rs733920 -- 48,562,341(-) ATGCT(G/T)GTCTC intron-variant
rs1062037 -- 48,560,792(-) GAAGC(A/G)CACAC intron-variant
rs890432 -- 48,551,870(-) TGACC(C/T)CTGAC intron-variant, utr-variant-3-prime
rs2555110 -- 48,572,869(-) CATTG(C/T)GTTGG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXB3 Gene

Variant ID Type Subtype PubMed ID
dgv1478n106 CNV deletion 24896259
dgv369n27 CNV loss 19166990
dgv5676n54 CNV loss 21841781
esv1007307 CNV deletion 20482838
esv2758694 CNV gain 17122850
nsv1118763 CNV deletion 24896259
nsv833469 CNV loss 17160897
nsv833471 CNV gain 17160897
nsv953922 CNV deletion 24416366

Variation tolerance for HOXB3 Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.54; 29.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB3 Gene

Disorders for HOXB3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOXB3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search HOXB3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOXB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB3
genes like me logo Genes that share disorders with HOXB3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB3 Gene

Publications for HOXB3 Gene

  1. HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. (PMID: 17972163) Chung N. … Rha H.K. (Mol. Biol. Rep. 2009) 3 22 65
  2. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. (PMID: 19854132) Palakurthy R.K. … Green M.R. (Mol. Cell 2009) 3 22 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. (PMID: 9556594) Guazzi S. … Boncinelli E. (J. Biol. Chem. 1998) 3 22 65
  5. Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context. (PMID: 9774637) ViganA^ M.A. … Mavilio F. (Mol. Cell. Biol. 1998) 3 22 65

Products for HOXB3 Gene

Sources for HOXB3 Gene

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