Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HOXB3 Gene

protein-coding   GIFtS: 51
GCID: GC17M046626

Homeobox B3

(Previous name: homeo box B3)
(Previous symbols: HOX2, HOX2G)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Homeobox B31 2     Homeobox Protein Hox-2G2 3
HOX2G1 2 3 5     Hox-2.72
HOX21 2     Homeo Box 2G2
Homeo Box B31 2     Homeobox Protein Hox-B32
Homeobox Protein Hox-2.72 3     

External Ids:    HGNC: 51141   Entrez Gene: 32132   Ensembl: ENSG000001200937   OMIM: 1429665   UniProtKB: P146513   
ORGUL members:         

Export aliases for HOXB3 gene to outside databases

Previous GC identifers: GC17M046338 GC17M049107 GC17M046969 GC17M047101 GC17M043983 GC17M041996


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HOXB3 Gene:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding
domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions
as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is
associated with a distinct biologic subset of acute myeloid leukemia (AML). (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB3 Gene:
HOXB3 (homeobox B3) is a protein-coding gene. Diseases associated with HOXB3 include vacterl association, and esophageal atresia. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXB3_HUMAN, P14651
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXB3 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB3 promoter sequence
   Search Chromatin IP Primers for HOXB3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046626:  view genomic region     (about GC identifiers)

Start:
46,626,232 bp from pter      End:
46,682,274 bp from pter
Size:
56,043 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HXB3_HUMAN, P14651 (See protein sequence)
Recommended Name: Homeobox protein Hox-B3  
Size: 431 amino acids; 44340 Da
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: A8K567 D3DTV3 O95615 P17484

Explore the universe of human proteins at neXtProt for HOXB3: NX_P14651

Explore proteomics data for HOXB3 at MOPED


See HOXB3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002137.4  
ENSEMBL proteins: 
 ENSP00000417207   ENSP00000419676   ENSP00000308252   ENSP00000420595   ENSP00000449977  
 ENSP00000418035   ENSP00000418729   ENSP00000418892   ENSP00000417400   ENSP00000446783  
 ENSP00000438747  

HOXB3 Human Recombinant Protein Products:

Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
OriGene Custom MassSpec
OriGene Custom Protein Services for HOXB3
GenScript Custom Purified and Recombinant Proteins Services for HOXB3
Novus Biologicals HOXB3 Protein
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for HOXB3

HOXB3 Antibody Products:

Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for HOXB3
Novus Biologicals HOXB3 Antibody
Search for Antibodies for HOXB3 at Abcam
Cloud-Clone Corp. Antibodies for HOXB3
Search ThermoFisher Antibodies for HOXB3
LSBio Antibodies in human, mouse, rat for HOXB3

HOXB3 Assay Products:

Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for HOXB3
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for HOXB3
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for HOXB3
Cloud-Clone Corp. CLIAs for HOXB3


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus
HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

Selected InterPro protein domains (see all 6):
 IPR001827 Homeobox_Antennapedia_CS
 IPR020479 Homeobox_metazoa
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P14651

ProtoNet protein and cluster: P14651

2 Blocks protein domains:
IPB000047 Lambda and other repressor helix-turn-helix signature
IPB001827 Homeobox protein


UniProtKB/Swiss-Prot: HXB3_HUMAN, P14651
Similarity: Belongs to the Antp homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


HOXB3 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HXB3_HUMAN, P14651
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

     Genatlas biochemistry entry for HOXB3:
homeo box B3(2G),homologous to mouse Hox-2.7,Drosophila Zen

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0043565sequence-specific DNA binding ----
     
HOXB3 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for HOXB3:
 Wnt reporter downregulated 

     10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxb3):
 craniofacial  embryogenesis  endocrine/exocrine gland  hematopoietic system  immune system 
 mortality/aging  nervous system  normal  respiratory system  skeleton 

HOXB3 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Hoxb3tm1Mrc for HOXB3

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXB3
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXB3

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXB3
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXB3

miRNA
Products:
    
miRTarBase miRNAs that target HOXB3:
hsa-mir-10a-5p (MIRT025627)

Block miRNA regulation of human, mouse, rat HOXB3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HOXB3 (see all 79):
hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-4272 hsa-miR-374a hsa-miR-519a hsa-miR-3161 hsa-miR-3613-3p
SwitchGear 3'UTR luciferase reporter plasmidHOXB3 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HOXB3
Predesigned siRNA for gene silencing in human, mouse, rat HOXB3

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HOXB3

Clone
Products:
     
OriGene clones in human, mouse for HOXB3 (see all 6)
OriGene ORF clones in mouse, rat for HOXB3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXB3 (NM_002146)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB3

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for HOXB3
Browse ESI BIO Cell Lines and PureStem Progenitors for HOXB3 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB3


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot
HXB3_HUMAN, P14651: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

HOXB3 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus



    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXB3: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for HOXB3

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for HOXB3 (P146513 ENSP000003082524) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
About this table

Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0001525angiogenesis IEP17972163
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0009952anterior/posterior pattern specification IEA--

HOXB3 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus
Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HOXB3 (HXB3)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for HOXB3 gene: 
NM_002146.4  

Unigene Cluster for HOXB3:

Homeobox B3
Hs.654560  [show with all ESTs]
Unigene Representative Sequence: NM_002146
14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000470495(uc002inn.3 uc002ino.3 uc010wlk.2 uc010wll.2 uc010wlm.2 uc010dbf.3 uc010dbg.3)
ENST00000472863 ENST00000311626 ENST00000498678 ENST00000490677 ENST00000460160
ENST00000489475 ENST00000476342 ENST00000471459 ENST00000465120 ENST00000478644
ENST00000464266 ENST00000552000 ENST00000485909
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HOXB3 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HOXB3 (see all 79):
hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-4272 hsa-miR-374a hsa-miR-519a hsa-miR-3161 hsa-miR-3613-3p
SwitchGear 3'UTR luciferase reporter plasmidHOXB3 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HOXB3
Predesigned siRNA for gene silencing in human, mouse, rat HOXB3
Clone
Products:
     
OriGene clones in human, mouse for HOXB3 (see all 6)
OriGene ORF clones in mouse, rat for HOXB3
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXB3 (NM_002146)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB3
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB3
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for HOXB3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB3
  QuantiTect SYBR Green Assays in human, mouse, rat HOXB3
  QuantiFast Probe-based Assays in human, mouse, rat HOXB3

Additional mRNA sequence: 

AK027609.1 AK291182.1 AK299226.1 AK299265.1 AK309721.1 AK315102.1 AK316245.1 X16667.1 

8 DOTS entries:

DT.40118139  DT.120919415  DT.435198  DT.95097958  DT.120919433  DT.204604  DT.40126964  DT.91805018 

21 AceView cDNA sequences:

BE676812 AA303036 AA303037 AA952925 BU179121 AI702564 AK027609 AW135928 
AI739053 U59298 AI554404 CD517099 NM_002146 BX103550 BE349975 X16667 
AI215090 AI796199 AA301768 AI684087 BQ027917 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

HOXB3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AACTCAGCTC
HOXB3 Expression
About this image


HOXB3 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 11) fully expand
 
 Endothelium (Cardiovascular System)    fully expand to see all 3 entries
         Angioblasts Embryonic Blood Islands
 
 Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
         Angioblasts Embryonic Blood Islands
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Medulla Oblongata
         Anterior astroglia-like cells
 
 NULL (Uncategorized)    fully expand to see all 2 entries
         Vascular endothelial growth factor-induced embryoid bodies
 
 Lung (Respiratory System)    fully expand to see all 2 entries
         Proximal Mesodermal Progenitor Cells Lung Mesoderm
HOXB3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HOXB3 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654560
    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXB3: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for HOXB3
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB3
QuantiTect SYBR Green Assays in human, mouse, rat HOXB3
QuantiFast Probe-based Assays in human, mouse, rat HOXB3
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB3

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for HOXB3 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hoxb31 , 5 homeobox B31, 5 91.09(n)1
95.35(a)1
  11 (59.84 cM)5
154101  NM_001079869.11  NP_001073338.11 
 963233265 
chicken
(Gallus gallus)
Aves HOXB31 homeobox B3 71.27(n)
71.36(a)
  395502  NM_204743.1  NP_990074.1 
lizard
(Anolis carolinensis)
Reptilia HOXB36
homeobox B3
66(a)
1 ↔ 1
6(75513232-75520712)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.154502 Transcribed sequence with weak similarity to protein more 79.53(n)    CF150160.1 
zebrafish
(Danio rerio)
Actinopterygii hoxb3a2 homeo box B3a 73.38(n)   30339  AJ537509.1 


ENSEMBL Gene Tree for HOXB3 (if available)
TreeFam Gene Tree for HOXB3 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section

TryGeneCards Plus
Paralogs for HOXB3 gene
GSX12  HOXA32  MEOX12  EVX22  HOXA12  HOXB12  HOXD12  HOXA22  
GSX22  EVX12  HOXB22  MEOX22  PDX12  HOXD32  
11 SIMAP similar genes for HOXB3 using alignment to 6 protein entries:     HXB3_HUMAN (see all proteins):
HOX B6    HOXD8    HOXC13    HOXA3    HLX    HOXA4
HOXD3    MNX1    NKX2-5    HOXD11    HOXB1

HOXB3 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for HOXB3
PGOHUM00000240692


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

Selected SNPs for HOXB3 (see all 399)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs8904321,2
C,F,A,H--46629232(-) TGACCT/CCTGAC 1 -- int123Minor allele frequency- C:0.31EA NS NA CSA WA 3847
rs2008864321,2
--46629413(+) TTTCAC/GCTTGG 2 L V mis10--------
rs1999315811,2
--46629464(+) GGTGAA/GGGTGG 2 L F mis10--------
rs626375831,2
C,F--46629479(+) GGTGCC/TGGGAC 2 S G mis12Minor allele frequency- T:0.00NS NA 4610
rs1823666971,2
C--46629480(+) GTGCCA/GGGACC 2 P syn10--------
rs2018599691,2
--46629536(+) GTTGCC/TAGTGG 2 S G mis10--------
rs22293041,2,,4
C,F,A--46629593(-) CCGAGA/CCCCTG 2 T P mis1 ese312Minor allele frequency- C:0.40MN NS NA CSA WA EA EU 4606
rs1448955271,2
C--46629610(+) GACCCG/AGCCTC 2 /P /L mis11Minor allele frequency- A:0.00NA 4002
rs2011241861,2
--46629698(+) CTGGTA/TGTCGC 2 N Y mis10--------
rs2007969221,2
C--46629740(+) TTGGGG/AGGGGA 2 /P /S mis11Minor allele frequency- A:0.00EU 1257

HapMap Linkage Disequilibrium report for HOXB3 (46626232 - 46682274 bp)

Structural Variations
     Database of Genomic Variants (DGV) 8 variations for HOXB3:    About this table    
Variant IDTypeSubtypePubMed ID
esv1007307CNV Deletion20482838
nsv833469CNV Loss17160897
dgv3222n71CNV Loss21882294
dgv3223n71CNV Loss21882294
dgv369n27CNV Loss19166990
dgv3224n71CNV Loss21882294
nsv833471CNV Gain17160897
dgv988e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HOXB3
DNA2.0 Custom Variant and Variant Library Synthesis for HOXB3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus
OMIM gene information: 142966    OMIM disorders: --

13 diseases for HOXB3:    
About MalaCards
vacterl association    esophageal atresia    myeloid leukemia    acute myeloid leukemia
leukemia    lymphoblastic leukemia    esophagitis    endotheliitis
pancreatic cancer    thyroiditis    pancreatitis    prostate cancer
prostatitis

1 disease from the University of Copenhagen DISEASES database for HOXB3:
VACTERL association

HOXB3 for disorders           About GeneDecksing

1 Novoseek inferred disease relationship for HOXB3 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia 8.36 1 11113197 (1)


Export disorders for HOXB3 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for HOXB3 gene, integrated from 10 sources (see all 39):
(articles sorted by number of sources associating them with HOXB3)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
  3. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
  4. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (Nucleic Acids Res. 1989)
  5. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (Differentiation 1989)
  6. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
  7. Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. (PubMed id 9556594)1, 9 Guazzi S....Boncinelli E. (J. Biol. Chem. 1998)
  8. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. (PubMed id 19854132)1, 9 Palakurthy R.K....Green M.R. (Mol. Cell 2009)
  9. HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. (PubMed id 17972163)1, 9 Chung N....Rha H.K. (Mol. Biol. Rep. 2009)
  10. The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. (PubMed id 7913891)1, 9 Guazzi S....Mavilio F. (EMBO J. 1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus
Entrez Gene: 3213 HGNC: 5114 AceView: HOXB3 Ensembl:ENSG00000120093 euGenes: HUgn3213
ECgene: HOXB3 H-InvDB: HOXB3

(According to HUGE)
About This Section

TryGeneCards Plus
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus
NameDescription
PharmGKB entry for HOXB3 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section

TryGeneCards Plus
Patent Information for HOXB3 gene:
Search GeneIP for patents involving HOXB3

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus

 
 EMD Millipore genomic analysis products

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
 Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HOXB3  
 Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for HOXB3  
 OriGene qSTAR qPCR primer pairs in human, mouse for HOXB3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for HOXB3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for HOXB3   OriGene Custom Protein Services for HOXB3  

 
 
 Block miRNA regulation of human, mouse, rat HOXB3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HOXB3
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXB3 Predesigned siRNA for gene silencing in human, mouse, rat HOXB3
 QuantiFast Probe-based Assays in human, mouse, rat HOXB3 QuantiTect SYBR Green Assays in human, mouse, rat HOXB3
 PCR Arrays including human, mouse, rat HOXB3 Search Chromatin IP Primers for HOXB3
 Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB3  Search GeneGlobe Interaction Network for HOXB3
 Regulatory tfbs in HOXB3 promoter
 GenScript Custom Purified and Recombinant Proteins Services for HOXB3 GenScript cDNA clones with any tag delivered in your preferred vector for HOXB3
 GenScript Custom Assay Services for HOXB3 GenScript Custom overexpressing Cell Line Services for HOXB3
 CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
 Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
 Plasmid Preparation Custom Peptide Services
 Search for Antibodies & Assays

 Search Tocris compounds for HOXB3 (HXB3)
 Browse Sino Biological Proteins
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

 Novus Tissue Slides
 HOXB3 antibodies
 HOXB3 proteins
 Search for Antibodies for HOXB3 at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for HOXB3
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins
 Proteins for HOXB3
 Antibodies for HOXB3
 ELISAs for HOXB3
 CLIAs for HOXB3



 Browse ESI BIO Cell Lines and PureStem Progenitors for HOXB3
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB3
 SwitchGear 3'UTR luciferase reporter plasmids for HOXB3
 SwitchGear Promoter luciferase reporter plasmids for HOXB3
 Search ThermoFisher Antibodies for HOXB3
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB3
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXB3
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXB3
 LSBio Antibodies in human, mouse, rat for HOXB3
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
 Browse compounds at ApexBio
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category
(GIFtS: )
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      HOXB3 gene at Home site.
Version: 3.12.142 28 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4