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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB3 Gene

protein-coding   GIFtS: 52
GCID: GC17M046626

Homeobox B3

(Previous name: homeo box B3)
(Previous symbols: HOX2, HOX2G)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homeobox B31 2     Homeobox Protein Hox-2G2 3
HOX2G1 2 3 5     Hox-2.72
HOX21 2     Homeo Box 2G2
Homeo Box B31 2     Homeobox Protein Hox-B32
Homeobox Protein Hox-2.72 3     

External Ids:    HGNC: 51141   Entrez Gene: 32132   Ensembl: ENSG000001200937   OMIM: 1429665   UniProtKB: P146513   

Export aliases for HOXB3 gene to outside databases

Previous GC identifers: GC17M046338 GC17M049107 GC17M046969 GC17M047101 GC17M043983 GC17M041996


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXB3 Gene:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding
domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions
as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is
associated with a distinct biologic subset of acute myeloid leukemia (AML). (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB3 Gene: 
HOXB3 (homeobox B3) is a protein-coding gene. Diseases associated with HOXB3 include vacterl association, and esophageal atresia. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXB3_HUMAN, P14651
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB3 gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-1   ATF-2   E2F-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.3   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046626:  view genomic region     (about GC identifiers)

Start:
46,626,232 bp from pter      End:
46,682,274 bp from pter
Size:
56,043 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXB3_HUMAN, P14651 (See protein sequence)
Recommended Name: Homeobox protein Hox-B3  
Size: 431 amino acids; 44340 Da
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: A8K567 D3DTV3 O95615 P17484

Explore the universe of human proteins at neXtProt for HOXB3: NX_P14651

Explore proteomics data for HOXB3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14651

  • HOXB3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXB3 Protein Expression
    REFSEQ proteins: NP_002137.4  
    ENSEMBL proteins: 
     ENSP00000417207   ENSP00000419676   ENSP00000308252   ENSP00000420595   ENSP00000449977  
     ENSP00000418035   ENSP00000418729   ENSP00000418892   ENSP00000417400   ENSP00000446783  
     ENSP00000438747  

    Human Recombinant Protein Products for HOXB3: 
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    Novus Biologicals HOXB3 Protein
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXB3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXB3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P14651

    ProtoNet protein and cluster: P14651

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXB3_HUMAN, P14651
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXB3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB3_HUMAN, P14651
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB3:
    homeo box B3(2G),homologous to mouse Hox-2.7,Drosophila Zen

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000979RNA polymerase II core promoter sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    HOXB3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXB3:
     Wnt reporter downregulated 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxb3):
     craniofacial  embryogenesis  endocrine/exocrine gland  hematopoietic system  immune system 
     mortality/aging  nervous system  normal  respiratory system  skeleton 

    HOXB3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Hoxb3tm1Mrc for HOXB3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXB3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXB3

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    miRNA
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    hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-4272 hsa-miR-374a hsa-miR-519a hsa-miR-3161 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHOXB3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXB3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for HOXB3 (P146513 ENSP000003082524) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMGB1P094293, ENSP000003430404I2D: score=1 STRING: ENSP00000343040
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    EP300Q094723, ENSP000002632534I2D: score=1 STRING: ENSP00000263253
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001525angiogenesis IEP17972163
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0009952anterior/posterior pattern specification IEA--

    HOXB3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB3 (HXB3)

    Search CenterWatch for drugs/clinical trials and news about HOXB3 / HXB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXB3 gene: 
    NM_002146.4  

    Unigene Cluster for HOXB3:

    Homeobox B3
    Hs.654560  [show with all ESTs]
    Unigene Representative Sequence: NM_002146
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000470495(uc002inn.3 uc002ino.3 uc010wlk.2 uc010wll.2 uc010wlm.2 uc010dbf.3 uc010dbg.3)
    ENST00000472863 ENST00000311626 ENST00000498678 ENST00000490677 ENST00000460160
    ENST00000489475 ENST00000476342 ENST00000471459 ENST00000465120 ENST00000478644
    ENST00000464266 ENST00000552000 ENST00000485909
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB3
    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB3 (see all 79):
    hsa-miR-548j hsa-miR-520e hsa-miR-607 hsa-miR-4272 hsa-miR-374a hsa-miR-519a hsa-miR-3161 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidHOXB3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXB3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB3
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    GenScript: all cDNA clones in your preferred vector: HOXB3 (NM_002146)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB3
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    Additional mRNA sequence: 

    AK027609.1 AK291182.1 AK299226.1 AK299265.1 AK309721.1 AK315102.1 AK316245.1 X16667.1 

    8 DOTS entries:

    DT.40118139  DT.120919415  DT.435198  DT.95097958  DT.120919433  DT.204604  DT.40126964  DT.91805018 

    21 AceView cDNA sequences:

    BE676812 AA303037 AA952925 AA303036 BU179121 U59298 BX103550 NM_002146 
    AI739053 AK027609 AW135928 AI554404 CD517099 X16667 AI215090 AI702564 
    BE349975 AI684087 AI796199 AA301768 BQ027917 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB3 expression in normal human tissues (normalized intensities)      HOXB3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTCAGCTC
    HOXB3 Expression
    About this image


    HOXB3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 5 entries
             Angioblasts Embryonic Capillary Plexus
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 3 entries
             Angioblasts Embryonic Capillary Plexus
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
             brain/hindbrain   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Proximal Mesodermal Progenitor Cells Lung Mesoderm
     
     Neural Crest (Gastrulation Derivatives)
             Cardiac Neural Crest Cells Branchial Arch 3,4,6

    See HOXB3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB3

    SOURCE GeneReport for Unigene cluster: Hs.654560
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXB3: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXB3 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxb31 , 5 homeobox B31, 5 91.55(n)1
    96.05(a)1
      11 (59.84 cM)5
    154101  NM_001079869.11  NP_001073338.11 
     963233265 
    chicken
    (Gallus gallus)
    Aves HOXB31 homeobox B3 72.17(n)
    70.81(a)
      395502  NM_204743.1  NP_990074.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXB36
    --
    Uncharacterized protein
    66(a)
    33(a)
    1 ↔ 1
    possible ortholog
    6(75513232-75520712)
    2(71908820-71911179)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154502 Transcribed sequence with weak similarity to protein more 79.53(n)    CF150160.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxb3a2 homeo box B3a 73.38(n)   30339  AJ537509.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta zen26
    zen6
    zerknullt
    22(a)
    17(a)
    many ↔ many
    many ↔ many
    3R(2568854-2569862)
    3R(2578586-2579916)
    worm
    (Caenorhabditis elegans)
    Secernentea mab-56
    egl-56
    Homeobox protein egl-5
    25(a)
    18(a)
    many ↔ many
    many ↔ many
    III(7776907-7783454)
    III(7814382-7816451)


    ENSEMBL Gene Tree for HOXB3 (if available)
    TreeFam Gene Tree for HOXB3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB3 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB52  HOXC62  HOXC52  
    GSX22  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  HOXA32  
    HOXD82  HOXB62  HOXB12  HOXB82  HOXB22  HOXD42  PDX12  HOXB72  
    HOXC42  
    11 SIMAP similar genes for HOXB3 using alignment to 6 protein entries:     HXB3_HUMAN (see all proteins):
    HOX B6    HOXD8    HOXC13    HOXA3    HLX    HOXA4
    HOXD3    MNX1    NKX2-5    HOXD11    HOXB1

    HOXB3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HOXB3
    PGOHUM00000240692


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/399 SNPs in HOXB3 are shown (see all 399)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8904321,2
    C,F,A,H--46629232(-) TGACCT/CCTGAC 1 -- int123Minor allele frequency- C:0.31EA NS NA CSA WA 3847
    rs2008864321,2
    --46629413(+) TTTCAC/GCTTGG 2 L V mis10--------
    rs1999315811,2
    --46629464(+) GGTGAA/GGGTGG 2 L F mis10--------
    rs626375831,2
    C,F--46629479(+) GGTGCC/TGGGAC 2 S G mis12Minor allele frequency- T:0.00NS NA 4610
    rs1823666971,2
    C--46629480(+) GTGCCA/GGGACC 2 P syn10--------
    rs2018599691,2
    --46629536(+) GTTGCC/TAGTGG 2 S G mis10--------
    rs22293041,2,4
    C,F,A--46629593(-) CCGAGA/CCCCTG 2 T P mis1 ese312Minor allele frequency- C:0.40MN NS NA CSA WA EA EU 4606
    rs1448955271,2
    C--46629610(+) GACCCG/AGCCTC 2 /P /L mis11Minor allele frequency- A:0.00NA 4002
    rs2011241861,2
    --46629698(+) CTGGTA/TGTCGC 2 N Y mis10--------
    rs2007969221,2
    C--46629740(+) TTGGGG/AGGGGA 2 /P /S mis11Minor allele frequency- A:0.00EU 1257

    HapMap Linkage Disequilibrium report for HOXB3 (46626232 - 46682274 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for HOXB3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1007307CNV Deletion20482838
    nsv833469CNV Loss17160897
    dgv3222n71CNV Loss21882294
    dgv3223n71CNV Loss21882294
    dgv369n27CNV Loss19166990
    dgv3224n71CNV Loss21882294
    nsv833471CNV Gain17160897
    dgv988e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142966    OMIM disorders: --

    12 diseases for HOXB3:    About MalaCards
    vacterl association    esophageal atresia    acute myeloid leukemia    myeloid leukemia
    leukemia    acute lymphoblastic leukemia    lymphoblastic leukemia    esophagitis
    pancreatic cancer    pancreatitis    thyroiditis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for HOXB3:
    VACTERL association

    HOXB3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HOXB3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 8.36 1 11113197 (1)


    Export disorders for HOXB3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB3 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with HOXB3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    3. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    4. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    5. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
    6. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    7. Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells. (PubMed id 9556594)1, 9 Guazzi S....Boncinelli E. (1998)
    8. Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression. (PubMed id 19854132)1, 9 Palakurthy R.K....Green M.R. (2009)
    9. HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. (PubMed id 17972163)1, 9 Chung N....Rha H.K. (2009)
    10. The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. (PubMed id 7913891)1, 9 Guazzi S....Mavilio F. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3213 HGNC: 5114 AceView: HOXB3 Ensembl:ENSG00000120093 euGenes: HUgn3213
    ECgene: HOXB3 H-InvDB: HOXB3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXB3 gene:
    Search GeneIP for patents involving HOXB3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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