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Set Analyses:

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HOXB2 Gene

protein-coding GIFtS: 52
GCID: GC17M046620

Homeobox B2

(Previous name: homeo box B2)
(Previous symbols: HOX2, HOX2H)

See related diseases
at

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Homeobox B2¹ ²		K8² ³
HOX2H¹ ² ³ ⁵		Hox-2.8²
HOX2¹ ²		Homeo Box 2H²
Homeo Box B2¹ ²		Homeobox Protein Hox-B2²
Homeobox Protein Hox-2.8² ³		K8 Home Protein²
Homeobox Protein Hox-2H² ³

External Ids:	HGNC: 5113¹	Entrez Gene: 3212²	Ensembl: ENSG00000173917⁷	OMIM: 142967⁵	UniProtKB: P14652³

Export aliases for HOXB2 gene to outside databases

Previous GC identifers: GC17M046331 GC17M049100 GC17M046962 GC17M047094 GC17M043975 GC17M041989

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXB2 Gene:

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding

domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions

as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is

associated with pancreatic cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB2 Gene:

HOXB2 (homeobox B2) is a protein-coding gene. Diseases associated with HOXB2 include bamforth-lazarus syndrome, and bell's palsy. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652

Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides

cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000017.11 NT_010783.16 NC_018928.2

Regulatory elements:

Regulatory transcription factor binding sites in the HOXB2 gene promoter:
Egr-3 Lmo2 IRF-1 POU3F2 Tal-1beta N-Myc FOXO4 ITF-2 CBF(2) Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXB2 promoter sequence

Search Chromatin IP Primers for HOXB2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32

HOXB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M046620: view genomic region (about GC identifiers)

Start:	46,618,256 bp from pter	End:	46,623,441 bp from pter
Size:	5,186 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652 (See protein sequence)

Recommended Name: Homeobox protein Hox-B2

Size: 356 amino acids; 37914 Da

Subunit: Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed

at least by SATB1 and HOXB2

Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception

Secondary accessions: P10913 P17485

Explore the universe of human proteins at neXtProt for HOXB2: NX_P14652

Explore proteomics data for HOXB2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See HOXB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_002136.1

ENSEMBL proteins:

ENSP00000331741

HOXB2 Human Recombinant Protein Products:

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	LSBio Antibodies in human, mouse, rat for HOXB2

HOXB2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
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	Cloud-Clone Corp. ELISAs for HOXB2 Cloud-Clone Corp. CLIAs for HOXB2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

HOXL: Homeoboxes / ANTP class : HOXL subclass

5 InterPro protein domains:

IPR001827 Homeobox_Antennapedia_CS

IPR020479 Homeobox_metazoa

IPR017970 Homeobox_CS

IPR001356 Homeobox_dom

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P14652

ProtoNet protein and cluster: P14652

2 Blocks protein domains:

IPB000047 Lambda and other repressor helix-turn-helix signature

IPB001827 Homeobox protein

UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652

Similarity: Belongs to the Antp homeobox family. Proboscipedia subfamily

Similarity: Contains 1 homeobox DNA-binding domain

HOXB2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: HXB2_HUMAN, P14652

Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides

cells with specific positional identities on the anterior-posterior axis

Genatlas biochemistry entry for HOXB2:

homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

HOXB2 for ontologies About GeneDecksing

Phenotypes:
12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hoxb2):

behavior/neurological	craniofacial	embryogenesis	growth/size/body	hearing/vestibular/ear
mortality/aging	muscle	nervous system	normal	respiratory system
skeleton	vision/eye

HOXB2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for HOXB2: Hoxb2^tm1Mrc Hoxb2^tm3.2Fmr Hoxb2^tm2.2Fmr

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXB2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXB2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXB2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXB2

miRNA Products:		miRTarBase miRNAs that target HOXB2: hsa-mir-17-3p (MIRT050781)

		Block miRNA regulation of human, mouse, rat HOXB2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate HOXB2 (see all 11):
		hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641

		SwitchGear 3'UTR luciferase reporter plasmid: HOXB2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HOXB2
		Predesigned siRNA for gene silencing in human, mouse, rat HOXB2

Gene Editing
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DNA2.0 Custom Protein Engineering Service for HOXB2

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		GenScript: all cDNA clones in your preferred vector: HOXB2 (NM_002145)
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		ESI BIO PureStem Progenitor for HOXB2: PureStem 4D20.8, NCr-fac Progenitor

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

HXB2_HUMAN, P14652: Nucleus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	5

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

HOXB2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Pathway & Disease-focused RT² Profiler PCR Array including HOXB2:

Homeobox (HOX) Genes in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for HOXB2

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

Selected Interacting proteins for HOXB2 (P14652³ ENSP00000331741⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREBBP	Q92793³, ENSP00000262367⁴	I2D: score=3 STRING: ENSP00000262367
SOD1	P00441³, ENSP00000270142⁴	I2D: score=2 STRING: ENSP00000270142
MNDA	P41218³, ENSP00000357123⁴	I2D: score=2 STRING: ENSP00000357123
EP300	Q09472³, ENSP00000263253⁴	I2D: score=2 STRING: ENSP00000263253
TNKS2	ENSP00000360689⁴	STRING: ENSP00000360689

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Gene Ontology (GO): Selected biological process terms (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002011	morphogenesis of an epithelial sheet	IEA	--
GO:0006351	transcription, DNA-templated	IEA	--
GO:0006355	regulation of transcription, DNA-templated	--	--
GO:0007275	multicellular organismal development	TAS	7876223
GO:0008015	blood circulation	TAS	7876223

HOXB2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for HOXB2 (HXB2)

3 Novoseek inferred chemical compound relationships for HOXB2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphorothioate	62.8	1	11835749 (1)
retinoic acid	38.8	5	15867264 (4)
vegf	13	2	15730655 (1), 15996286 (1)

HOXB2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for HOXB2 gene:

NM_002145.3

Unigene Cluster for HOXB2:

Homeobox B2

Hs.514289 [show with all ESTs]

Unigene Representative Sequence: NM_002145

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000504772 ENST00000330070(uc002inm.3) ENST00000571287 ENST00000574746

miRNA Products:		Block miRNA regulation of human, mouse, rat HOXB2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate HOXB2 (see all 11):
		hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641

		SwitchGear 3'UTR luciferase reporter plasmid: HOXB2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for HOXB2
		Predesigned siRNA for gene silencing in human, mouse, rat HOXB2

Clone Products:		OriGene clones in human, mouse for HOXB2 (see all 6) OriGene ORF clones in mouse, rat for HOXB2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HOXB2 (NM_002145)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB2

Primer Products:		OriGene qPCR primer pairs and template standards for HOXB2 OriGene qSTAR qPCR primer pairs in human, mouse for HOXB2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat HOXB2
		QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
		QuantiFast Probe-based Assays in human, mouse, rat HOXB2

Additional mRNA sequence:

BC038968.1 BC074805.2 BC074806.2 M73999.1 X14571.1 X16665.1

3 DOTS entries:

DT.108697 DT.92032326 DT.95256456

Selected AceView cDNA sequences (see all 59):

CB216911 CF272219 BC074806 CB216818 X14571 BC074805 CA412496 NM_002145

AW611527 AA738470 AA450237 AI273508 BF445099 BX370020 BE907336 AA911661

BF224284 BI910090 BF445826 BE907604 CA418750 AI346403 BC038968 CA421364

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HOXB2 expression in normal human tissues (normalized intensities) HOXB2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: AAGCACAAGC

About this image

HOXB2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 4) fully expand


Head Mesenchyme (Muscoskeletal System) fully expand to see all 3 entries
Cranial Neural Crest Cells Branchial Arch 2
Branchial Arch 2

Neural Crest (Gastrulation Derivatives) fully expand to see all 2 entries
Cranial Neural Crest Cells Branchial Arch 2

NULL (Uncategorized) fully expand to see all 3 entries
Vascular endothelial growth factor-induced embryoid bodies

Lung (Respiratory System)
Distal Mesodermal Progenitor Cells Lung Mesoderm

HOXB2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

HOXB2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.514289

Pathway & Disease-focused RT² Profiler PCR Array including HOXB2:

Homeobox (HOX) Genes in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for HOXB2 OriGene qSTAR qPCR primer pairs in human, mouse for HOXB2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat HOXB2
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HOXB2 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hoxb2^{1 , 5}	homeobox B2^{1, 5}	82.72(n)¹ 80.45(a)¹		11 (59.85 cM)⁵ 103889¹ NM_134032.2¹ NP_598793.2¹ 96350525⁵
chicken (Gallus gallus)	Aves	HOXB2¹	homeobox B2	68.91(n) 69.87(a)		429940 XM_003642792.2 XP_003642840.1
lizard (Anolis carolinensis)	Reptilia	HOXB2⁶	homeobox B2	57(a)	1 ↔ 1	6(75492178-75495933)
tropical clawed frog (Xenopus tropicalis)	Amphibia	hoxb2¹	homeobox B2	64.55(n) 63.44(a)		100038155 XM_002938018.2 XP_002938064.2
zebrafish (Danio rerio)	Actinopterygii	hoxb2a²	homeo box B2a	79.43(n)		30338 AF071568.1
fruit fly (Drosophila melanogaster)	Insecta	pb⁶	proboscipedia	15(a)	1 → many	3R(2533518-2567785)

ENSEMBL Gene Tree for HOXB2 (if available)
TreeFam Gene Tree for HOXB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for HOXB2 gene

GSX1² HOXA3² MEOX1² EVX2² HOXA1² HOXB1² HOXB3² HOXD1²

HOXA2² GSX2² EVX1² MEOX2² PDX1² HOXD3²

2 SIMAP similar genes for HOXB2 using alignment to 2 protein entries: HXB2_HUMAN (see all proteins):

HOX2.8 HOXA2

HOXB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
Database of Genomic Variants (DGV) 7 variations for HOXB2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv833469	CNV	Loss	17160897
dgv3222n71	CNV	Loss	21882294
dgv3223n71	CNV	Loss	21882294
dgv369n27	CNV	Loss	19166990
dgv3224n71	CNV	Loss	21882294
nsv833471	CNV	Gain	17160897
dgv988e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing HOXB2

DNA2.0 Custom Variant and Variant Library Synthesis for HOXB2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 142967 OMIM disorders: --

Selected diseases for HOXB2 (see all 21): About MalaCards

bamforth-lazarus syndrome bell's palsy omphalocele lung adenocarcinoma

pancreatic cancer primary pulmonary hypertension epididymitis pancreatitis

oral cancer acute myeloid leukemia hypertension endotheliitis

lung cancer myeloid leukemia ovarian cancer adenocarcinoma

cervicitis thyroiditis leukemia breast cancer

1 disease from the University of Copenhagen DISEASES database for HOXB2:

Bamforth-Lazarus syndrome

HOXB2 for disorders About GeneDecksing

1 Novoseek inferred disease relationship for HOXB2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	6	15867264 (2), 17805056 (1), 16445654 (1)

Genetic Association Database (GAD): HOXB2
Human Genome Epidemiology (HuGE) Navigator: HOXB2 (2 documents)

Export disorders for HOXB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HOXB2 gene, integrated from 10 sources (see all 47):
(articles sorted by number of sources associating them with HOXB2)

Utopia: connect your pdf to the dynamic
world of online information

The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PubMed id 10595394)^{1, 2, 9} Case S.S.... Lloyd J.A. (DNA Cell Biol. 1999)
Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PubMed id 7876223)^{1, 2, 9} Vieille-Grosjean I. and Huber P. (J. Biol. Chem. 1995)
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PubMed id 20195514)^{1, 4, 9} Pillas D....Jarvelin M.R. (PLoS Genet. 2010)
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PubMed id 20628624)^{1, 4} Johnatty S.E.... . (PLoS Genet. 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Vertebrate homeobox gene nomenclature. (PubMed id 1358459)^{1, 3} Scott M.P. (Cell 1992)
Nomenclature for human homeobox genes. (PubMed id 1973146)^{1, 3} McAlpine P.J. and Shows T.B. (Genomics 1990)
The human HOX gene family. (PubMed id 2574852)^{1, 2} Acampora D.... Boncinelli E. (Nucleic Acids Res. 1989)
Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)^{1, 2} Giampaolo A.... Peschle C. (Differentiation 1989)
Organization of human class I homeobox genes. (PubMed id 2576652)^{1, 2} Boncinelli E.... Simeone A. (Genome 1989)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3212	HGNC: 5113	AceView: HOXB2	Ensembl:ENSG00000173917	euGenes: HUgn3212
ECgene: HOXB2	H-InvDB: HOXB2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for HOXB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HOXB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HOXB2 gene:
Search GeneIP for patents involving HOXB2

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