Aliases for HOXB2 Gene
Aliases for HOXB2 Gene
External Ids for HOXB2 Gene
- HGNC: 5113
- Entrez Gene: 3212
- Ensembl: ENSG00000173917
- OMIM: 142967
- UniProtKB: P14652
Previous HGNC Symbols for HOXB2 Gene
- HOX2
- HOX2H
Previous GeneCards Identifiers for HOXB2 Gene
- GC17M046331
- GC17M049100
- GC17M046962
- GC17M047094
- GC17M043975
- GC17M046620
- GC17M041989
Summaries for HOXB2 Gene
-
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB2 Gene
HOXB2 (Homeobox B2) is a Protein Coding gene. Diseases associated with HOXB2 include Bamforth-Lazarus Syndrome. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA2.
UniProtKB/Swiss-Prot for HOXB2 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB2 Gene
Genomics for HOXB2 Gene
Regulatory Elements for HOXB2 Gene
Enhancers for HOXB2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXB2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HOXB2 Gene
- Chromosome:
- 17
- Start:
- 48,540,894 bp from pter
- End:
- 48,545,031 bp from pter
- Size:
- 4,138 bases
- Orientation:
- Minus strand
Genomic View for HOXB2 Gene
Genes around HOXB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
HOXB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXB2 Gene
Proteins for HOXB2 Gene
-
Protein details for HOXB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14652-HXB2_HUMAN
- Recommended name:
- Homeobox protein Hox-B2
- Protein Accession:
- P14652
- P10913
- P17485
Protein attributes for HOXB2 Gene
- Size:
- 356 amino acids
- Molecular mass:
- 37914 Da
- Quaternary structure:
-
- Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.
Protein Expression for HOXB2 Gene
Post-translational modifications for HOXB2 Gene
Other Protein References for HOXB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOXB2
- Novus Biologicals Antibodies for HOXB2
- Invitrogen Antibodies for HOXB2
- antibodies-online Antibodies for HOXB2: See all 38
- GeneTex HOXB2 antibody for HOXB2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HOXB2
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- Novus Biologicals proteins for HOXB2
- antibodies-online Proteins for HOXB2: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXB2
Assay Products
- antibodies-online Kits for HOXB2: See all 1
No data available for DME Specific Peptides for HOXB2 Gene
Domains & Families for HOXB2 Gene
Gene Families for HOXB2 Gene
Protein Domains for HOXB2 Gene
Suggested Antigen Peptide Sequences for HOXB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P14652- Family:
-
- Belongs to the Antp homeobox family. Proboscipedia subfamily.
Function for HOXB2 Gene
Molecular function for HOXB2 Gene
- GENATLAS Biochemistry:
- homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXB2 Gene
- MGI mutant phenotypes for HOXB2:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HOXB2:
Animal Models for HOXB2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB2 gene
- Search ViGene Biosciences for HOXB2
CRISPR Products
-
OriGene CRISPR knockouts for HOXB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB2
- GenScript: Design CRISPR guide RNA sequences for HOXB2
miRNA for HOXB2 Gene
- miRTarBase miRNAs that target HOXB2
miRNA Products
- Search ViGene Biosciences for HOXB2
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB2 gene
Clone Products
-
OriGene ORF clones in human for HOXB2
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Cell Line Products
- ESI BIO PureStem 4D20.8, NCr-fac Progenitor for HOXB2
-
Horizon Cell Lines for HOXB2
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXB2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXB2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB2 Gene
Localization for HOXB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXB2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016607 | nuclear speck | IDA | -- |
Pathways & Interactions for HOXB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for HOXB2 Gene
Interacting Proteins for HOXB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002011 | morphogenesis of an epithelial sheet | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 7876223 |
| GO:0008015 | blood circulation | TAS | 7876223 |
No data available for SIGNOR curated interactions for HOXB2 Gene
Transcripts for HOXB2 Gene
mRNA/cDNA for HOXB2 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (59) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXB2
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXB2
- GenScript: Design CRISPR guide RNA sequences for HOXB2
miRNA Products
- Search ViGene Biosciences for HOXB2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXB2
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXB2 gene
Clone Products
-
OriGene ORF clones in human for HOXB2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXB2
Flow Cytometry Products
Expression for HOXB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Head Mesenchyme (Muscoskeletal System)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
- Cranial Neural Crest Cells Branchial Arch 2
- Branchial Arch 2
- NULL (Uncategorized)
-
Neural Crest (Gastrulation Derivatives)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
- Cranial Neural Crest Cells Branchial Arch 2
-
Lung (Respiratory System)
- Distal Mesodermal Progenitor Cells Lung Mesoderm
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXB2 Gene:
HOXB2SOURCE GeneReport for Unigene cluster for HOXB2 Gene:
Hs.514289Evidence on tissue expression from TISSUES for HOXB2 Gene
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for HOXB2
-
OriGene qPCR primer pairs for HOXB2
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB2 Gene
Orthologs for HOXB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXB2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXB2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXB2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxb2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxb2 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXB2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXB2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXB2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXB2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxb2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxb2a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | pb 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXB2 Gene
Variants for HOXB2 Gene
| SNP ID | Clin | Chr 17 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000535670 | -- | 48,545,897(+) | GCTTG(-/T)TATCT | intron-variant, upstream-variant-2KB | |
| rs1000896268 | -- | 48,545,853(+) | AAACA(A/G)GCAGA | intron-variant, upstream-variant-2KB | |
| rs1001596513 | -- | 48,546,663(+) | AGGAG(A/G)AGAAG | intron-variant, upstream-variant-2KB | |
| rs1002799671 | -- | 48,542,469(+) | GACTT(C/T)TGCCG | downstream-variant-500B, upstream-variant-2KB | |
| rs1002863760 | -- | 48,545,198(+) | GAAAA(C/G)AGAGA | nc-transcript-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.65;
45.72% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXB2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXB2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB2 Gene
Disorders for HOXB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bamforth-lazarus syndrome |
|
|
Search HOXB2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXB2
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB2 Gene
Publications for HOXB2 Gene
- Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PMID: 20195514) Pillas D. … Jarvelin M.R. (PLoS Genet. 2010) 3 22 46 64
- The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PMID: 10595394) Case S.S. … Lloyd J.A. (DNA Cell Biol. 1999) 3 4 22 64
- Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PMID: 7876223) Vieille-Grosjean I. … Huber P. (J. Biol. Chem. 1995) 3 4 22 64
- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64
- HOXB2 as a novel prognostic indicator for stage I lung adenocarcinomas. (PMID: 17805056) Inamura K. … Ishikawa Y. (J Thorac Oncol 2007) 3 22 64
Products for HOXB2 Gene
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- Novus Biologicals Antibodies for HOXB2
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- antibodies-online Antibodies for HOXB2: See all 38
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
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- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
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- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
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- (98) BioGPS
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- (100) COMPARTMENTS
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- (105) antibodies-online
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- (109) TreeFam
- (110) PathCards
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- (112) GeneTex
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