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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB2 Gene

protein-coding   GIFtS: 53
GCID: GC17M046620

homeobox B2

(Previous name: homeo box B2 )
(Previous symbols: HOX2, HOX2H)
 Explore 24 diseases affiliated with
HOXB2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXB2    

Aliases
for HOXB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox B21 2     K82 3
HOX2H1 2 3 5     Hox-2.82
HOX21 2     Homeo Box 2H2
Homeo Box B21 2     Homeobox Protein Hox-B22
Homeobox Protein Hox-2.82 3     K8 Home Protein2
Homeobox Protein Hox-2H2 3     

External Ids:    HGNC: 51131   Entrez Gene: 32122   Ensembl: ENSG000001739177   OMIM: 1429675   UniProtKB: P146523   

Export aliases for HOXB2 gene to outside databases

Previous GC identifers: GC17M046331 GC17M049100 GC17M046962 GC17M047094 GC17M043975 GC17M041989


Summaries
for HOXB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXB2:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It
is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a
sequence-specific transcription factor that is involved in development. Increased expression of this gene is
associated with pancreatic cancer. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB2


Genomic Views
for HOXB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB2 gene promoter:
         Egr-3   Lmo2   IRF-1   POU3F2   Tal-1beta   N-Myc   FOXO4   ITF-2   CBF(2)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046620:  view genomic region     (about GC identifiers)

Start:
 46,618,256 bp from pter      End:
 46,623,441 bp from pter
Size:
 5,186 bases      Orientation:
 minus strand

Proteins
for HOXB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652 (See protein sequence)
Recommended Name: Homeobox protein Hox-B2  
Size: 356 amino acids; 37914 Da
Subunit: Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at
least by SATB1 and HOXB2
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: P10913 P17485

Explore the universe of human proteins at neXtProt for HOXB2: NX_P14652

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14652

    • HOXB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002136.1  
    ENSEMBL proteins: 
     ENSP00000331741  

    Human Recombinant Protein Products: 
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    Uscn Proteins for HOXB2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    HOXB2 for ontologies           About GeneDecksing



    HOXB2 Antibody Products: 
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    Uscn Antibodies for HOXB2
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    Uscn ELISAs and CLIAs for HOXB2

    Protein Domains /
    Families
    for HOXB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXB2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P14652

    ProtoNet protein and cluster: P14652

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
    Similarity: Belongs to the Antp homeobox family. Proboscipedia subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB2:
    homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB2 (see all 11):
    hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB2 (see all 4)
    OriGene shRNA RFP: HOXB2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXB2

    Clone
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB2 

    Cell Line
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    LifeMap BioReagents: cell line associated with HOXB2: PureStem 4D20.8, NCr-fac Progenitor

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--


    HOXB2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Hoxb2tm1Mrc for HOXB2
         10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Hoxb2):
     behavior/neurological  craniofacial  embryogenesis  growth/size  mortality/aging 
     muscle  nervous system  respiratory system  skeleton  vision/eye 

    HOXB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for HOXB2 (P146523 ENSP000003317414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=3 STRING: ENSP00000262367
    SOD1P004413, ENSP000002701424I2D: score=2 STRING: ENSP00000270142
    MNDAP412183, ENSP000003571234I2D: score=2 STRING: ENSP00000357123
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    TNKS2ENSP000003606894STRING: ENSP00000360689
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development TAS7876223
    GO:0008015blood circulation TAS7876223
    GO:0009952anterior/posterior pattern specification IEA--


    HOXB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB2
    3 Novoseek chemical compound relationships for HOXB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphorothioate 62.8 1 11835749 (1)
    retinoic acid 38.8 5 15867264 (4)
    vegf 13 2 15730655 (1), 15996286 (1)

    Search CenterWatch for drugs/clinical trials and news about HOXB2 / HXB2 

    Transcripts
    for HOXB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXB2 gene: 
    NM_002145.3  

    Unigene Cluster for HOXB2:

    Homeobox B2
    Hs.514289  [show with all ESTs]
    Unigene Representative Sequence: NM_002145
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504772 ENST00000330070(uc002inm.3) ENST00000571287 ENST00000574746


    miRNA
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    hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB2 (see all 4)
    OriGene shRNA RFP: HOXB2
    OriGene siRNA: HOXB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB2
    Clone
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB2

    Additional cDNA sequence: 

    BC038968.1 BC074805.2 BC074806.2 M73999.1 X14571.1 X16665.1 

    3 DOTS entries:

    DT.108697  DT.92032326  DT.95256456 

    24/59 AceView cDNA sequences (see all 59):

    CF272219 BC074806 CB216911 X14571 CB216818 BC074805 CA428352 AW611527 
    NM_002145 CA421364 BE907604 BF224284 BM759853 AI273508 BF445099 AA911661 
    BC038968 AA450237 AW591025 AI346403 CA418750 BE907336 BX370020 BI910090 

    GeneLoc Exon Structure


    Expression
    for HOXB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCACAAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 2Cranial Neural Crest CellsNeural Crest
    Head MesenchymeBranchial Arch 3,4,6Cardiac Neural Crest CellsNeural Crest
    LungLung MesodermDistal Mesodermal Progenitor CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11) 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Posterior foregut-like cells (A scalable, suspensi...)
    Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
    Mesendoderm (Derivation and sorti...)

    See HOXB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB2

    SOURCE GeneReport for Unigene cluster: Hs.514289
        SABiosciences Expression via Pathway-Focused PCR Array including HOXB2: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2

    Orthologs
    for HOXB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HOXB2 gene from 3/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXB21 homeobox B2 70.29(n)
    69.33(a)    		   429940  XM_003642792.1  XP_003642840.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXB26
    		 --
    		 49(a)
    		 1 ↔ 1
    		 6(75492178-75495933)
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxb2a2 homeo box B2a 79.43(n)   30338  AF071568.1 


    ENSEMBL Gene Tree for HOXB2 (if available)
    TreeFam Gene Tree for HOXB2 (if available) 

    Paralogs
    for HOXB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB2 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXB42  HOXA52  HOXA42  HOXD32  HOXC82  HOXA62  
    HOXA32  HOXD82  HOXB12  HOXB62  HOXB82  HOXD42  HOXB72  PDX12  
    HOXC42  
    2 SIMAP similar genes for HOXB2 using alignment to 2 protein entries:     HXB2_HUMAN (see all proteins):
    HOX2.8    HOXA2

    HOXB2 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/86 NCBI SNPs in HOXB2 are shown (see all 86)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs728298451,2
    		C,--41989012(+) CACCCT/CCCTCT 1 -- us2k12Minor allele frequency- C:0.11CSA NA 121
    rs757075661,2
    		--41989369(+) AATCTA/GTGAAA 1 -- us2k10--------
    rs10428221,2
    		C,F,--41989416(-) AAATTC/ATTTAA 1 -- us2k110Minor allele frequency- A:0.14MN NA WA CSA EA 553
    rs10428181,2
    		C,F,--41989432(-) TGTAGA/GTNNNN 1 -- us2k18Minor allele frequency- G:0.14MN NA WA CSA 315
    rs739858571,2
    		C,--41989524(+) TTTCAT/CTGGAA 1 -- us2k12Minor allele frequency- C:0.14WA 120
    rs794994761,2
    		C,F,--41989622(+) TAAACG/ACTAAT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs23260141,2
    		C,F,H--41990345(+) TCCTTC/TTCCAG 1 -- int1 trp34Minor allele frequency- T:0.01NS EA 418
    rs23260151,2
    		C,F,A,H,--41990712(+) CCCCTC/TCCAAG 1 -- int1 trp38Minor allele frequency- T:0.02NS EA NA 970
    rs116503891,2
    		C,F,A,H,--41990989(+) CAGCCA/TTAGGG 1 -- int14Minor allele frequency- T:0.07NA CSA WA 242
    rs802447421,2
    		C--41991437(-) AACCTC/TCCCCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for HOXB2 (46618256 - 46623441 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for HOXB2
         3 CNVs: 53230 4040 77654

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    Disorders / Diseases
    for HOXB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXB2 for disorders           About GeneDecksing

    OMIM gene information: 142967    OMIM disorders: --

    20/24 diseases for HOXB2 (see all 24):    About MalaCards
    bamforth-lazarus syndrome    pancreatic cancer    pancreatitis    bell's palsy
    primary pulmonary hypertension    pulmonary hypertension    acute myeloid leukemia    myeloid leukemia
    embryonal carcinoma    epididymitis    emphysema    hypertension
    oral cancer    lung adenocarcinoma    cervical carcinoma    cervicitis
    ovarian cancer    leukemia    lung cancer    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for HOXB2:
    Bamforth-Lazarus syndrome

    1 Novoseek disease relationship for HOXB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 6 15867264 (2), 17805056 (1), 16445654 (1)

    Human Genome Epidemiology (HuGE) Navigator: HOXB2 (2 documents)

    Export disorders for HOXB2 gene to outside databases

    Publications
    for HOXB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB2 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with HOXB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PubMed id 10595394)1, 2, 9 Case S.S.... Lloyd J.A. (1999)
    2. Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PubMed id 7876223)1, 2, 9 Vieille-Grosjean I. and Huber P. (1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    6. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    7. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
    8. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    9. Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages. (PubMed id 2901346)1, 2 Kongsuwan K.... Adams J.M. (1988)
    10. Expression of HOXB2, a retinoic acid signaling target in pancreatic cancer and pancreatic intraepithelial neoplasia. (PubMed id 15867264)1, 9 Segara D....Henshall S.M. (2005)

    External Searches for HOXB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3212 HGNC: 5113 AceView: HOXB2 Ensembl:ENSG00000173917 euGenes: HUgn3212
    ECgene: HOXB2 H-InvDB: HOXB2

    Other Databases showing HOXB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXB2 gene:
    Search GeneIP for patents involving HOXB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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