Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



HOXB2 Gene

protein-coding   GIFtS: 52
GCID: GC17M046620

Homeobox B2

(Previous name: homeo box B2)
(Previous symbols: HOX2, HOX2H)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Homeobox B21 2     K82 3
HOX2H1 2 3 5     Hox-2.82
HOX21 2     Homeo Box 2H2
Homeo Box B21 2     Homeobox Protein Hox-B22
Homeobox Protein Hox-2.82 3     K8 Home Protein2
Homeobox Protein Hox-2H2 3     

External Ids:    HGNC: 51131   Entrez Gene: 32122   Ensembl: ENSG000001739177   OMIM: 1429675   UniProtKB: P146523   

Export aliases for HOXB2 gene to outside databases

Previous GC identifers: GC17M046331 GC17M049100 GC17M046962 GC17M047094 GC17M043975 GC17M041989


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for HOXB2 Gene:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding
domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions
as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is
associated with pancreatic cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB2 Gene:
HOXB2 (homeobox B2) is a protein-coding gene. Diseases associated with HOXB2 include bamforth-lazarus syndrome, and bell's palsy. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXB2 gene promoter:
         Egr-3   Lmo2   IRF-1   POU3F2   Tal-1beta   N-Myc   FOXO4   ITF-2   CBF(2)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB2 promoter sequence
   Search Chromatin IP Primers for HOXB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046620:  view genomic region     (about GC identifiers)

Start:
46,618,256 bp from pter      End:
46,623,441 bp from pter
Size:
5,186 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652 (See protein sequence)
Recommended Name: Homeobox protein Hox-B2  
Size: 356 amino acids; 37914 Da
Subunit: Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed
at least by SATB1 and HOXB2
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: P10913 P17485

Explore the universe of human proteins at neXtProt for HOXB2: NX_P14652

Explore proteomics data for HOXB2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002136.1  
    ENSEMBL proteins: 
     ENSP00000331741  

    HOXB2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for HOXB2
    GenScript Custom Purified and Recombinant Proteins Services for HOXB2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXB2

    HOXB2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for HOXB2
    OriGene Custom Antibody Services for HOXB2
    Novus Biologicals HOXB2 Antibodies
    Abcam antibodies for HOXB2
    Cloud-Clone Corp. Antibodies for HOXB2
    Search ThermoFisher Antibodies for HOXB2
    LSBio Antibodies in human, mouse, rat for HOXB2

    HOXB2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HOXB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HOXB2
    Cloud-Clone Corp. CLIAs for HOXB2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5 InterPro protein domains:
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P14652

    ProtoNet protein and cluster: P14652

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
    Similarity: Belongs to the Antp homeobox family. Proboscipedia subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXB2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB2_HUMAN, P14652
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB2:
    homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXB2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Hoxb2):
     behavior/neurological  craniofacial  embryogenesis  growth/size/body  hearing/vestibular/ear 
     mortality/aging  muscle  nervous system  normal  respiratory system 
     skeleton  vision/eye 

    HOXB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXB2: Hoxb2tm1Mrc Hoxb2tm3.2Fmr Hoxb2tm2.2Fmr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXB2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXB2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXB2

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXB2:
    hsa-mir-17-3p (MIRT050781)

    Block miRNA regulation of human, mouse, rat HOXB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXB2 (see all 11):
    hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidHOXB2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXB2
    Predesigned siRNA for gene silencing in human, mouse, rat HOXB2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HOXB2

    Clone
    Products:
         
    OriGene clones in human, mouse for HOXB2 (see all 6)
    OriGene ORF clones in mouse, rat for HOXB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXB2 (NM_002145)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HOXB2
    ESI BIO PureStem Progenitor for HOXB2: 
    PureStem 4D20.8, NCr-fac Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HXB2_HUMAN, P14652: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXB2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including HOXB2: 
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for HOXB2 (P146523 ENSP000003317414) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=3 STRING: ENSP00000262367
    SOD1P004413, ENSP000002701424I2D: score=2 STRING: ENSP00000270142
    MNDAP412183, ENSP000003571234I2D: score=2 STRING: ENSP00000357123
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    TNKS2ENSP000003606894STRING: ENSP00000360689
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development TAS7876223
    GO:0008015blood circulation TAS7876223

    HOXB2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXB2 (HXB2)

    3 Novoseek inferred chemical compound relationships for HOXB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphorothioate 62.8 1 11835749 (1)
    retinoic acid 38.8 5 15867264 (4)
    vegf 13 2 15730655 (1), 15996286 (1)



    HOXB2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for HOXB2 gene: 
    NM_002145.3  

    Unigene Cluster for HOXB2:

    Homeobox B2
    Hs.514289  [show with all ESTs]
    Unigene Representative Sequence: NM_002145
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504772 ENST00000330070(uc002inm.3) ENST00000571287 ENST00000574746

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXB2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXB2 (see all 11):
    hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidHOXB2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXB2
    Predesigned siRNA for gene silencing in human, mouse, rat HOXB2
    Clone
    Products:
         
    OriGene clones in human, mouse for HOXB2 (see all 6)
    OriGene ORF clones in mouse, rat for HOXB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXB2 (NM_002145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HOXB2
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB2
      QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
      QuantiFast Probe-based Assays in human, mouse, rat HOXB2

    Additional mRNA sequence: 

    BC038968.1 BC074805.2 BC074806.2 M73999.1 X14571.1 X16665.1 

    3 DOTS entries:

    DT.108697  DT.92032326  DT.95256456 

    Selected AceView cDNA sequences (see all 59):

    CB216911 CF272219 BC074806 CB216818 X14571 BC074805 CA412496 NM_002145 
    AW611527 AA738470 AA450237 AI273508 BF445099 BX370020 BE907336 AA911661 
    BF224284 BI910090 BF445826 BE907604 CA418750 AI346403 BC038968 CA421364 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    HOXB2 expression in normal human tissues (normalized intensities)      HOXB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCACAAGC
    HOXB2 Expression
    About this image


    HOXB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Cranial Neural Crest Cells Branchial Arch 2
             Branchial Arch 2
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 2
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Vascular endothelial growth factor-induced embryoid bodies
     
     Lung (Respiratory System)
             Distal Mesodermal Progenitor Cells Lung Mesoderm
    HOXB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514289
        Pathway & Disease-focused RT2 Profiler PCR Array including HOXB2: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HOXB2
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXB2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB2
    QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
    QuantiFast Probe-based Assays in human, mouse, rat HOXB2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for HOXB2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxb21 , 5 homeobox B21, 5 82.72(n)1
    80.45(a)1
      11 (59.85 cM)5
    1038891  NM_134032.21  NP_598793.21 
     963505255 
    chicken
    (Gallus gallus)
    Aves HOXB21 homeobox B2 68.91(n)
    69.87(a)
      429940  XM_003642792.2  XP_003642840.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXB26
    homeobox B2
    57(a)
    1 ↔ 1
    6(75492178-75495933)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hoxb21 homeobox B2 64.55(n)
    63.44(a)
      100038155  XM_002938018.2  XP_002938064.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxb2a2 homeo box B2a 79.43(n)   30338  AF071568.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pb6
    proboscipedia
    15(a)
    1 → many
    3R(2533518-2567785)


    ENSEMBL Gene Tree for HOXB2 (if available)
    TreeFam Gene Tree for HOXB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for HOXB2 gene
    GSX12  HOXA32  MEOX12  EVX22  HOXA12  HOXB12  HOXB32  HOXD12  
    HOXA22  GSX22  EVX12  MEOX22  PDX12  HOXD32  
    2 SIMAP similar genes for HOXB2 using alignment to 2 protein entries:     HXB2_HUMAN (see all proteins):
    HOX2.8    HOXA2

    HOXB2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOXB2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833469CNV Loss17160897
    dgv3222n71CNV Loss21882294
    dgv3223n71CNV Loss21882294
    dgv369n27CNV Loss19166990
    dgv3224n71CNV Loss21882294
    nsv833471CNV Gain17160897
    dgv988e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXB2
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXB2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 142967    OMIM disorders: --

    Selected diseases for HOXB2 (see all 21):    About MalaCards
    bamforth-lazarus syndrome    bell's palsy    omphalocele    lung adenocarcinoma
    pancreatic cancer    primary pulmonary hypertension    epididymitis    pancreatitis
    oral cancer    acute myeloid leukemia    hypertension    endotheliitis
    lung cancer    myeloid leukemia    ovarian cancer    adenocarcinoma
    cervicitis    thyroiditis    leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HOXB2:
    Bamforth-Lazarus syndrome

    HOXB2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HOXB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 6 15867264 (2), 17805056 (1), 16445654 (1)

    Genetic Association Database (GAD): HOXB2
    Human Genome Epidemiology (HuGE) Navigator: HOXB2 (2 documents)

    Export disorders for HOXB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for HOXB2 gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with HOXB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PubMed id 10595394)1, 2, 9 Case S.S.... Lloyd J.A. (DNA Cell Biol. 1999)
    2. Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PubMed id 7876223)1, 2, 9 Vieille-Grosjean I. and Huber P. (J. Biol. Chem. 1995)
    3. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PubMed id 20195514)1, 4, 9 Pillas D....Jarvelin M.R. (PLoS Genet. 2010)
    4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    8. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (Nucleic Acids Res. 1989)
    9. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (Differentiation 1989)
    10. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 3212 HGNC: 5113 AceView: HOXB2 Ensembl:ENSG00000173917 euGenes: HUgn3212
    ECgene: HOXB2 H-InvDB: HOXB2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for HOXB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for HOXB2 gene:
    Search GeneIP for patents involving HOXB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for HOXB2   OriGene RNAi products in human, mouse, rat for HOXB2  
     OriGene qPCR primer pairs and template standards for HOXB2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HOXB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for HOXB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HOXB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXB2   OriGene Custom Protein Services for HOXB2  

     
     
     Block miRNA regulation of human, mouse, rat HOXB2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing HOXB2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXB2 Predesigned siRNA for gene silencing in human, mouse, rat HOXB2
     QuantiFast Probe-based Assays in human, mouse, rat HOXB2 QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
     PCR Arrays including human, mouse, rat HOXB2 Search Chromatin IP Primers for HOXB2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB2  Search GeneGlobe Interaction Network for HOXB2
     Regulatory tfbs in HOXB2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for HOXB2 GenScript cDNA clones with any tag delivered in your preferred vector for HOXB2
     GenScript Custom Assay Services for HOXB2 GenScript Custom overexpressing Cell Line Services for HOXB2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for HOXB2 (HXB2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     HOXB2 antibodies
     Antibodies for HOXB2
     See all of Abcam's Antibodies, Kits and Proteins for HOXB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for HOXB2
     Antibodies for HOXB2
     ELISAs for HOXB2
     CLIAs for HOXB2



     PureStem Progenitor for HOXB2: PureStem 4D20.8, NCr-fac Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2
     SwitchGear 3'UTR luciferase reporter plasmids for HOXB2
     SwitchGear Promoter luciferase reporter plasmids for HOXB2
     Search ThermoFisher Antibodies for HOXB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXB2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXB2
     LSBio Antibodies in human, mouse, rat for HOXB2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HOXB2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4