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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB2 Gene

protein-coding   GIFtS: 52
GCID: GC17M046620

Homeobox B2

(Previous name: homeo box B2)
(Previous symbols: HOX2, HOX2H)
  21 related diseases
at
MalaCards
 

Aliases
for HOXB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Homeobox B21 2     K82 3
HOX2H1 2 3 5     Hox-2.82
HOX21 2     Homeo Box 2H2
Homeo Box B21 2     Homeobox Protein Hox-B22
Homeobox Protein Hox-2.82 3     K8 Home Protein2
Homeobox Protein Hox-2H2 3     

External Ids:    HGNC: 51131   Entrez Gene: 32122   Ensembl: ENSG000001739177   OMIM: 1429675   UniProtKB: P146523   

Export aliases for HOXB2 gene to outside databases

Previous GC identifers: GC17M046331 GC17M049100 GC17M046962 GC17M047094 GC17M043975 GC17M041989


Summaries
for HOXB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXB2 Gene:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It
is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a
sequence-specific transcription factor that is involved in development. Increased expression of this gene is
associated with pancreatic cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB2 Gene: 
HOXB2 (homeobox B2) is a protein-coding gene. Diseases associated with HOXB2 include bamforth-lazarus syndrome, and bell's palsy. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB2 Gene


Genomic Views
for HOXB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB2 gene promoter:
         Egr-3   Lmo2   IRF-1   POU3F2   Tal-1beta   N-Myc   FOXO4   ITF-2   CBF(2)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046620:  view genomic region     (about GC identifiers)

Start:
 46,618,256 bp from pter      End:
 46,623,441 bp from pter
Size:
 5,186 bases      Orientation:
 minus strand

Proteins
for HOXB2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652 (See protein sequence)
Recommended Name: Homeobox protein Hox-B2  
Size: 356 amino acids; 37914 Da
Subunit: Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at
least by SATB1 and HOXB2
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: P10913 P17485

Explore the universe of human proteins at neXtProt for HOXB2: NX_P14652

Explore proteomics data for HOXB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14652

    • HOXB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXB2 Protein Expression
    REFSEQ proteins: NP_002136.1  
    ENSEMBL proteins: 
     ENSP00000331741  

    Human Recombinant Protein Products for HOXB2: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXB2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXB2 for ontologies           About GeneDecksing



    HOXB2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for HOXB2 

    Assay Products for HOXB2: 
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    Cloud-Clone Corp. ELISAs for HOXB2 
    Cloud-Clone Corp. CLIAs for HOXB2

    Protein Domains /
    Families
    for HOXB2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5 InterPro protein domains:
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P14652

    ProtoNet protein and cluster: P14652

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
    Similarity: Belongs to the Antp homeobox family. Proboscipedia subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXB2 for domains           About GeneDecksing


    Function
    for HOXB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB2_HUMAN, P14652
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB2:
    homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXB2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hoxb2):
     behavior/neurological  craniofacial  embryogenesis  growth/size  hearing/vestibular/ear 
     mortality/aging  muscle  nervous system  normal  respiratory system 
     skeleton  vision/eye 

    HOXB2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for HOXB2: Hoxb2tm1Mrc Hoxb2tm3.2Fmr Hoxb2tm2.2Fmr
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXB2

    miRNA
    Products:        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB2 (see all 11):
    hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HOXB2
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of HOXB2
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    Clone
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    OriGene clones in human, mouse for HOXB2 (see all 5)
    OriGene ORF clones in mouse, rat for HOXB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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    Browse Sino Biological Human cDNA Clones
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    Cell Line
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    LifeMap BioReagents: cell line associated with HOXB2: PureStem 4D20.8, NCr-fac Progenitor
    Sirion Biotech Customized stable knockdown cell line services for HOXB2
                         Customized inducible knockdown cell line services for HOXB2
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                         Customized inducible overexpressing cell line services for HOXB2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2


    Pathways & Interactions
    for HOXB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for HOXB2 (P146523 ENSP000003317414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=3 STRING: ENSP00000262367
    SOD1P004413, ENSP000002701424I2D: score=2 STRING: ENSP00000270142
    MNDAP412183, ENSP000003571234I2D: score=2 STRING: ENSP00000357123
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    TNKS2ENSP000003606894STRING: ENSP00000360689
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development TAS7876223
    GO:0008015blood circulation TAS7876223

    HOXB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB2 (HXB2)

    3 Novoseek inferred chemical compound relationships for HOXB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphorothioate 62.8 1 11835749 (1)
    retinoic acid 38.8 5 15867264 (4)
    vegf 13 2 15730655 (1), 15996286 (1)

    Search CenterWatch for drugs/clinical trials and news about HOXB2 / HXB2

    Transcripts
    for HOXB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXB2 gene: 
    NM_002145.3  

    Unigene Cluster for HOXB2:

    Homeobox B2
    Hs.514289  [show with all ESTs]
    Unigene Representative Sequence: NM_002145
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504772 ENST00000330070(uc002inm.3) ENST00000571287 ENST00000574746

    miRNA
    Products:         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB2 (see all 11):
    hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for HOXB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB2
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXB2
    Clone
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    OriGene ORF clones in mouse, rat for HOXB2
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    GenScript: all cDNA clones in your preferred vector: HOXB2 (NM_002145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB2
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB2

    Additional mRNA sequence: 

    BC038968.1 BC074805.2 BC074806.2 M73999.1 X14571.1 X16665.1 

    3 DOTS entries:

    DT.108697  DT.92032326  DT.95256456 

    24/59 AceView cDNA sequences (see all 59):

    BC074805 CB216911 BC074806 CF272219 X14571 CB216818 BE907604 BF445826 
    NM_002145 BF224284 BI910090 BM759853 AA911661 AW591025 CA428352 X16665 
    BF445099 CA418750 CA412496 AA450237 CA421364 BE907336 BQ771985 AI273508 

    GeneLoc Exon Structure


    Expression
    for HOXB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB2 expression in normal human tissues (normalized intensities)      HOXB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCACAAGC
    HOXB2 Expression
    About this image


    HOXB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Cranial Neural Crest Cells Branchial Arch 2
             Branchial Arch 2
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorting of renal cells from human...
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             "PureStem Z11, Meso Progenitor"
             DKK1-induced cells (Derivation of cardiomyocytes from induced pluripotent stem (iPS)...
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             "PureStem Z11, Meso Progenitor"
             Embryoid bodies (Two-step protocol for endothelial differentiation by embryoid body...
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 2

    See HOXB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB2

    SOURCE GeneReport for Unigene cluster: Hs.514289
        SABiosciences Expression via Pathway-Focused PCR Array including HOXB2: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2

    Orthologs
    for HOXB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXB2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hoxb21 , 5 homeobox B21, 5 83.57(n)1
    81.87(a)1    		   11 (59.85 cM)5
    1038891  NM_134032.21  NP_598793.21 
     963505255 
    chicken
    (Gallus gallus)    		 Aves HOXB21 homeobox B2 70.29(n)
    69.33(a)    		   429940  XM_003642792.1  XP_003642840.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXB26
    HOXA16
    		 Uncharacterized protein
    		 57(a)
    21(a)
    		 1 ↔ 1
    possible ortholog
    		 6(75492178-75495933)
    GL343275.1(1540176-1545152)
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxb2a2 homeo box B2a 79.43(n)   30338  AF071568.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-136
    		 Homeobox protein ceh-13
    		 26(a)
    		 1 → many
    		 III(7555660-7558208)


    ENSEMBL Gene Tree for HOXB2 (if available)
    TreeFam Gene Tree for HOXB2 (if available)

    Paralogs
    for HOXB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB2 gene
    GSX12  HOXA72  HOXA12  HOXB32  HOXD12  HOXA22  HOXB52  HOXC62  
    HOXC52  GSX22  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  
    HOXA32  HOXD82  HOXB62  HOXB12  HOXB82  HOXD42  PDX12  HOXB72  
    HOXC42  
    2 SIMAP similar genes for HOXB2 using alignment to 2 protein entries:     HXB2_HUMAN (see all proteins):
    HOX2.8    HOXA2

    HOXB2 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    		Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOXB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833469CNV Loss17160897
    dgv3222n71CNV Loss21882294
    dgv3223n71CNV Loss21882294
    dgv369n27CNV Loss19166990
    dgv3224n71CNV Loss21882294
    nsv833471CNV Gain17160897
    dgv988e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB2
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXB2

    Disorders / Diseases
    for HOXB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXB2 for disorders           About GeneDecksing

    OMIM gene information: 142967    OMIM disorders: --

    20/21 diseases for HOXB2 (see all 21):    About MalaCards
    bamforth-lazarus syndrome    bell's palsy    omphalocele    pancreatic cancer
    lung adenocarcinoma    primary pulmonary hypertension    epididymitis    pancreatitis
    oral cancer    acute myeloid leukemia    hypertension    endotheliitis
    lung cancer    myeloid leukemia    cervicitis    adenocarcinoma
    ovarian cancer    thyroiditis    leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HOXB2:
    Bamforth-Lazarus syndrome

    1 Novoseek inferred disease relationship for HOXB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 6 15867264 (2), 17805056 (1), 16445654 (1)

    Genetic Association Database (GAD): HOXB2
    Human Genome Epidemiology (HuGE) Navigator: HOXB2 (2 documents)

    Export disorders for HOXB2 gene to outside databases

    Publications
    for HOXB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB2 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with HOXB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PubMed id 10595394)1, 2, 9 Case S.S.... Lloyd J.A. (1999)
    2. Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PubMed id 7876223)1, 2, 9 Vieille-Grosjean I. and Huber P. (1995)
    3. Genome-wide association study reveals multiple loci a ssociated with primary tooth development during infancy. (PubMed id 20195514)1, 4, 9 Pillas D....Jarvelin M.R. (2010)
    4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    8. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    9. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
    10. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)

    External Searches for HOXB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3212 HGNC: 5113 AceView: HOXB2 Ensembl:ENSG00000173917 euGenes: HUgn3212
    ECgene: HOXB2 H-InvDB: HOXB2

    Other Databases showing HOXB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXB2 gene:
    Search GeneIP for patents involving HOXB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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