Aliases for HOXB2 Gene
Aliases for HOXB2 Gene
External Ids for HOXB2 Gene
- HGNC: 5113
- Entrez Gene: 3212
- Ensembl: ENSG00000173917
- OMIM: 142967
- UniProtKB: P14652
Previous HGNC Symbols for HOXB2 Gene
- HOX2
- HOX2H
Previous GeneCards Identifiers for HOXB2 Gene
- GC17M046331
- GC17M049100
- GC17M046962
- GC17M047094
- GC17M043975
- GC17M046620
- GC17M041989
Summaries for HOXB2 Gene
-
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB2 Gene
HOXB2 (Homeobox B2) is a Protein Coding gene. Diseases associated with HOXB2 include Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA2.
UniProtKB/Swiss-Prot for HOXB2 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB2 Gene
Genomics for HOXB2 Gene
GeneHancer (GH) Regulatory Elements for HOXB2 Gene
Promoters and enhancers for HOXB2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around HOXB2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for HOXB2 Gene
Genomic Locations for HOXB2 Gene
- chr17:48,540,894-48,545,031
- (GRCh38/hg38)
- Size:
- 4,138 bases
- Orientation:
- Minus strand
- chr17:46,618,256-46,623,441
- (GRCh37/hg19)
Genomic View for HOXB2 Gene
Genes around HOXB2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q21.32 by Ensembl
- 17q21.32 by Entrez Gene
- 17q21.32 by HGNC
HOXB2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXB2 Gene
Proteins for HOXB2 Gene
-
Protein details for HOXB2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P14652-HXB2_HUMAN
- Recommended name:
- Homeobox protein Hox-B2
- Protein Accession:
- P14652
- P10913
- P17485
Protein attributes for HOXB2 Gene
- Size:
- 356 amino acids
- Molecular mass:
- 37914 Da
- Quaternary structure:
-
- Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.
Protein Expression for HOXB2 Gene
Post-translational modifications for HOXB2 Gene
No Post-translational modifications
Other Protein References for HOXB2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
Abcam antibodies for HOXB2
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Protein Products
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Assay Products
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Quality Products:
No data available for DME Specific Peptides for HOXB2 Gene
Domains & Families for HOXB2 Gene
Gene Families for HOXB2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for HOXB2 Gene
Suggested Antigen Peptide Sequences for HOXB2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P14652- Family:
-
- Belongs to the Antp homeobox family. Proboscipedia subfamily.
Function for HOXB2 Gene
Molecular function for HOXB2 Gene
- GENATLAS Biochemistry:
- homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Phenotypes From GWAS Catalog for HOXB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IC | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IDA | 23332764 |
Phenotypes for HOXB2 Gene
- MGI mutant phenotypes for HOXB2:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for HOXB2:
Animal Models for HOXB2 Gene
Animal Model Products
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-
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-
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CRISPR Products
-
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-
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-
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miRNA for HOXB2 Gene
- miRTarBase miRNAs that target HOXB2
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-
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Cell Line Products
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-
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-
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-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXB2 Gene
Localization for HOXB2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXB2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Nucleus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005829 | cytosol | IDA | -- |
| GO:0016607 | nuclear speck | IDA | -- |
Pathways & Interactions for HOXB2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for HOXB2 Gene
Interacting Proteins for HOXB2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002011 | morphogenesis of an epithelial sheet | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
| GO:0007275 | multicellular organism development | TAS | 7876223 |
No data available for SIGNOR curated interactions for HOXB2 Gene
Transcripts for HOXB2 Gene
mRNA/cDNA for HOXB2 Gene
- (2) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (59) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXB2
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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Inhibitory RNA Products
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Clone Products
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-
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Expression for HOXB2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Head Mesenchyme (Muscoskeletal System)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
- Cranial Neural Crest Cells Branchial Arch 2
- Branchial Arch 2
- NULL (Uncategorized)
-
Neural Crest (Gastrulation Derivatives)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
- Cranial Neural Crest Cells Branchial Arch 2
-
Lung (Respiratory System)
- Distal Mesodermal Progenitor Cells Lung Mesoderm
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXB2 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXB2 Gene:
HOXB2SOURCE GeneReport for Unigene cluster for HOXB2 Gene:
Hs.514289Evidence on tissue expression from TISSUES for HOXB2 Gene
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for HOXB2
-
OriGene qPCR primer pairs and template standards for HOXB2
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No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB2 Gene
Orthologs for HOXB2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXB2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXB2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXB2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxb2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxb2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXB2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXB2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXB2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOXB2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxb2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxb2a 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | pb 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for HOXB2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXB2 Gene
Variants for HOXB2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000535670 | -- | 48,545,898(-) | T/TT | upstream_transcript_variant | |
| rs1000896268 | -- | 48,545,853(-) | G/A | upstream_transcript_variant | |
| rs1001596513 | -- | 48,546,663(-) | G/A/C | upstream_transcript_variant | |
| rs1002799671 | -- | 48,542,469(-) | T/C | downstream_transcript_variant | |
| rs1002863760 | -- | 48,545,198(-) | C/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.65;
45.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for HOXB2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXB2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB2 Gene
Disorders for HOXB2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate |
|
|
Search HOXB2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for HOXB2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXB2 Gene
Publications for HOXB2 Gene
- Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PMID: 20195514) Pillas D … Jarvelin MR (PLoS genetics 2010) 3 22 44 58
- The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PMID: 10595394) Case SS … Lloyd JA (DNA and cell biology 1999) 3 4 22 58
- Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PMID: 7876223) Vieille-Grosjean I … Huber P (The Journal of biological chemistry 1995) 3 4 22 58
- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
- HOXB2 as a novel prognostic indicator for stage I lung adenocarcinomas. (PMID: 17805056) Inamura K … Ishikawa Y (Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2007) 3 22 58
Products for HOXB2 Gene
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Sources for HOXB2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
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- (14) ProtoNet
- (15) Blocks
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- (17) IUBMB
- (18) KEGG
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
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- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
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- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew