Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB2 Gene

protein-coding   GIFtS: 52
GCID: GC17M046620

Homeobox B2

(Previous name: homeo box B2)
(Previous symbols: HOX2, HOX2H)
  See related diseases
at
MalaCards
 

Aliases
for HOXB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Homeobox B21 2     K82 3
HOX2H1 2 3 5     Hox-2.82
HOX21 2     Homeo Box 2H2
Homeo Box B21 2     Homeobox Protein Hox-B22
Homeobox Protein Hox-2.82 3     K8 Home Protein2
Homeobox Protein Hox-2H2 3     

External Ids:    HGNC: 51131   Entrez Gene: 32122   Ensembl: ENSG000001739177   OMIM: 1429675   UniProtKB: P146523   

Export aliases for HOXB2 gene to outside databases

Previous GC identifers: GC17M046331 GC17M049100 GC17M046962 GC17M047094 GC17M043975 GC17M041989


Summaries
for HOXB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXB2 Gene:
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding
domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions
as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is
associated with pancreatic cancer. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB2 Gene: 
HOXB2 (homeobox B2) is a protein-coding gene. Diseases associated with HOXB2 include bamforth-lazarus syndrome, and bell's palsy. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB2 Gene


Genomic Views
for HOXB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB2 gene promoter:
         Egr-3   Lmo2   IRF-1   POU3F2   Tal-1beta   N-Myc   FOXO4   ITF-2   CBF(2)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.32   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046620:  view genomic region     (about GC identifiers)

Start:
 46,618,256 bp from pter      End:
 46,623,441 bp from pter
Size:
 5,186 bases      Orientation:
 minus strand

Proteins
for HOXB2 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652 (See protein sequence)
Recommended Name: Homeobox protein Hox-B2  
Size: 356 amino acids; 37914 Da
Subunit: Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed
at least by SATB1 and HOXB2
Subcellular location: Nucleus
Developmental stage: Expressed in whole embryos and fetuses at 5-9 weeks from conception
Secondary accessions: P10913 P17485

Explore the universe of human proteins at neXtProt for HOXB2: NX_P14652

Explore proteomics data for HOXB2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P14652

    • HOXB2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXB2 Protein Expression
    REFSEQ proteins: NP_002136.1  
    ENSEMBL proteins: 
     ENSP00000331741  

    Human Recombinant Protein Products for HOXB2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HOXB2
    GenScript Custom Purified and Recombinant Proteins Services for HOXB2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXB2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXB2 for ontologies           About GeneDecksing



    HOXB2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HOXB2
    GenScript Custom Superior Antibodies Services for HOXB2
    Novus Biologicals HOXB2 Antibodies
    Abcam antibodies for HOXB2
    Cloud-Clone Corp. Antibodies for HOXB2 
    Search ThermoFisher Antibodies for HOXB2
    LSBio Antibodies in human, mouse, rat for HOXB2 

    Assay Products for HOXB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HOXB2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HOXB2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HOXB2 
    Cloud-Clone Corp. CLIAs for HOXB2

    Protein Domains /
    Families
    for HOXB2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5 InterPro protein domains:
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P14652

    ProtoNet protein and cluster: P14652

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXB2_HUMAN, P14652
    Similarity: Belongs to the Antp homeobox family. Proboscipedia subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXB2 for domains           About GeneDecksing


    Function
    for HOXB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB2_HUMAN, P14652
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB2:
    homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXB2 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Hoxb2):
     behavior/neurological  craniofacial  embryogenesis  growth/size  hearing/vestibular/ear 
     mortality/aging  muscle  nervous system  normal  respiratory system 
     skeleton  vision/eye 

    HOXB2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXB2: Hoxb2tm1Mrc Hoxb2tm3.2Fmr Hoxb2tm2.2Fmr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXB2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXB2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXB2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXB2 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB2 (see all 11):
    hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXB2
    Sirion Biotech Customized adenovirus for overexpression of HOXB2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HOXB2 (see all 5)
    OriGene ORF clones in mouse, rat for HOXB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXB2 (NM_002145)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB2
    Sirion Biotech Customized lentivirus for stable overexpression of HOXB2 
                         Customized lentivirus expression plasmids for stable overexpression of HOXB2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for HOXB2
    LifeMap BioReagents: cell line associated with HOXB2: PureStem 4D20.8, NCr-fac Progenitor
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2


    Pathways & Interactions
    for HOXB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for HOXB2 (P146523 ENSP000003317414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREBBPQ927933, ENSP000002623674I2D: score=3 STRING: ENSP00000262367
    SOD1P004413, ENSP000002701424I2D: score=2 STRING: ENSP00000270142
    MNDAP412183, ENSP000003571234I2D: score=2 STRING: ENSP00000357123
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    TNKS2ENSP000003606894STRING: ENSP00000360689
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development TAS7876223
    GO:0008015blood circulation TAS7876223

    HOXB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB2 (HXB2)

    3 Novoseek inferred chemical compound relationships for HOXB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphorothioate 62.8 1 11835749 (1)
    retinoic acid 38.8 5 15867264 (4)
    vegf 13 2 15730655 (1), 15996286 (1)

    Search CenterWatch for drugs/clinical trials and news about HOXB2 / HXB2

    Transcripts
    for HOXB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXB2 gene: 
    NM_002145.3  

    Unigene Cluster for HOXB2:

    Homeobox B2
    Hs.514289  [show with all ESTs]
    Unigene Representative Sequence: NM_002145
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000504772 ENST00000330070(uc002inm.3) ENST00000571287 ENST00000574746

    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB2
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB2 (see all 11):
    hsa-miR-142-5p hsa-miR-4324 hsa-miR-3617 hsa-miR-340 hsa-miR-3647-3p hsa-miR-544b hsa-miR-338-5p hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB2
    Clone
    Products:             		 OriGene clones in human, mouse for HOXB2 (see all 5)
    OriGene ORF clones in mouse, rat for HOXB2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXB2 (NM_002145)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB2
    Sirion Biotech Customized lentivirus for stable overexpression of HOXB2 
                         Customized lentivirus expression plasmids for stable overexpression of HOXB2 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for HOXB2
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB2

    Additional mRNA sequence: 

    BC038968.1 BC074805.2 BC074806.2 M73999.1 X14571.1 X16665.1 

    3 DOTS entries:

    DT.108697  DT.92032326  DT.95256456 

    24/59 AceView cDNA sequences (see all 59):

    BC074805 CB216911 BC074806 CF272219 X14571 CB216818 BE907604 BF445826 
    NM_002145 BF224284 BI910090 BM759853 AA911661 AW591025 CA428352 X16665 
    BF445099 CA418750 CA412496 AA450237 CA421364 BE907336 BQ771985 AI273508 

    GeneLoc Exon Structure


    Expression
    for HOXB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB2 expression in normal human tissues (normalized intensities)      HOXB2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCACAAGC
    HOXB2 Expression
    About this image


    HOXB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Uncategorized (Uncategorized)    fully expand to see all 5 entries
             PureStem Progenitor W10
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 3 entries
             Cranial Neural Crest Cells Branchial Arch 2
             Branchial Arch 2
     
     Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
             Cranial Neural Crest Cells Branchial Arch 2
     
     Brain (Nervous System)    fully expand to see all 2 entries
             future brain/future rhombencephalon/rhombomere 06   
     
     Mesoderm (Gastrulation Derivatives)
             PureStem Z11, Meso Progenitor

    See HOXB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB2

    SOURCE GeneReport for Unigene cluster: Hs.514289
        SABiosciences Expression via Pathway-Focused PCR Array including HOXB2: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for HOXB2
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXB2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2

    Orthologs
    for HOXB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXB2 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Hoxb21 , 5 homeobox B21, 5 83.57(n)1
    81.87(a)1    		   11 (59.85 cM)5
    1038891  NM_134032.21  NP_598793.21 
     963505255 
    chicken
    (Gallus gallus)    		 Aves HOXB21 homeobox B2 70.29(n)
    69.33(a)    		   429940  XM_003642792.1  XP_003642840.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXB26
    HOXA16
    		 Uncharacterized protein
    		 57(a)
    21(a)
    		 1 ↔ 1
    possible ortholog
    		 6(75492178-75495933)
    GL343275.1(1540176-1545152)
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxb2a2 homeo box B2a 79.43(n)   30338  AF071568.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ceh-136
    		 Homeobox protein ceh-13
    		 26(a)
    		 1 → many
    		 III(7555660-7558208)


    ENSEMBL Gene Tree for HOXB2 (if available)
    TreeFam Gene Tree for HOXB2 (if available)

    Paralogs
    for HOXB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB2 gene
    GSX12  HOXA72  HOXA12  HOXB32  HOXD12  HOXA22  HOXB52  HOXC62  
    HOXC52  GSX22  HOXB42  HOXA52  HOXA42  HOXD32  HOXA62  HOXC82  
    HOXA32  HOXD82  HOXB62  HOXB12  HOXB82  HOXD42  PDX12  HOXB72  
    HOXC42  
    2 SIMAP similar genes for HOXB2 using alignment to 2 protein entries:     HXB2_HUMAN (see all proteins):
    HOX2.8    HOXA2

    HOXB2 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    		Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOXB2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833469CNV Loss17160897
    dgv3222n71CNV Loss21882294
    dgv3223n71CNV Loss21882294
    dgv369n27CNV Loss19166990
    dgv3224n71CNV Loss21882294
    nsv833471CNV Gain17160897
    dgv988e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXB2
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXB2

    Disorders / Diseases
    for HOXB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 142967    OMIM disorders: --

    20/21 diseases for HOXB2 (see all 21):    About MalaCards
    bamforth-lazarus syndrome    bell's palsy    omphalocele    pancreatic cancer
    lung adenocarcinoma    primary pulmonary hypertension    epididymitis    pancreatitis
    oral cancer    acute myeloid leukemia    hypertension    endotheliitis
    lung cancer    myeloid leukemia    cervicitis    adenocarcinoma
    ovarian cancer    thyroiditis    leukemia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for HOXB2:
    Bamforth-Lazarus syndrome

    HOXB2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for HOXB2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 6 15867264 (2), 17805056 (1), 16445654 (1)

    Genetic Association Database (GAD): HOXB2
    Human Genome Epidemiology (HuGE) Navigator: HOXB2 (2 documents)

    Export disorders for HOXB2 gene to outside databases

    Publications
    for HOXB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB2 gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with HOXB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PubMed id 10595394)1, 2, 9 Case S.S.... Lloyd J.A. (1999)
    2. Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PubMed id 7876223)1, 2, 9 Vieille-Grosjean I. and Huber P. (1995)
    3. Genome-wide association study reveals multiple loci a ssociated with primary tooth development during infancy. (PubMed id 20195514)1, 4, 9 Pillas D....Jarvelin M.R. (2010)
    4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    8. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    9. Differential expression of human HOX-2 genes along the anterior- posterior axis in embryonic central nervous system. (PubMed id 2570724)1, 2 Giampaolo A.... Peschle C. (1989)
    10. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)

    External Searches for HOXB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3212 HGNC: 5113 AceView: HOXB2 Ensembl:ENSG00000173917 euGenes: HUgn3212
    ECgene: HOXB2 H-InvDB: HOXB2

    Other Databases showing HOXB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXB2 gene:
    Search GeneIP for patents involving HOXB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for HOXB2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HOXB2  
     OriGene qPCR primer pairs and template standards for HOXB2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HOXB2  
     OriGene qSTAR qPCR primer pairs in human, mouse for HOXB2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HOXB2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HOXB2   OriGene Custom Protein Services for HOXB2  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HOXB2
     QIAGEN SeqTarget long-range PCR primers for resequencing HOXB2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB2
     GenScript Custom Purified and Recombinant Proteins Services for HOXB2 GenScript cDNA clones with any tag delivered in your preferred vector for HOXB2
     GenScript Custom Assay Services for HOXB2 GenScript Custom Superior Antibodies Services for HOXB2
     GenScript Custom overexpressing Cell Line Services for HOXB2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HOXB2 promoter
     Search Chromatin IP Primers for HOXB2
     RT2 qPCR Primer Assay in human, mouse, rat HOXB2
     Search GNC Networks for HOXB2
     SABiosciences PCR Arrays including human, mouse, rat HOXB2
     Search Tocris compounds for HOXB2 (HXB2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HOXB2 antibodies
     Antibodies for HOXB2
     See all of Abcam's Antibodies, Kits and Proteins for HOXB2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HOXB2
     Antibodies for HOXB2
     ELISAs for HOXB2
     CLIAs for HOXB2
     Cell Line associated with HOXB2: PureStem 4D20.8, NCr-fac Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB2
     SwitchGear 3'UTR luciferase reporter plasmids for HOXB2
     SwitchGear Promoter luciferase reporter plasmids for HOXB2
     Search ThermoFisher Antibodies for HOXB2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXB2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXB2
    Customized:
     lentivirus for stable overexpression of HOXB2
     lentivirus expression plasmids for stable overexpression of HOXB2
     adenovirus for overexpression of HOXB2
     LSBio Antibodies in human, mouse, rat for HOXB2
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      HOXB2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4