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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXB13 Gene

protein-coding   GIFtS: 55
GCID: GC17M046802

homeobox B13

(Previous name: homeo box B13 )
 Explore 13 diseases affiliated with
HOXB13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXB13    

Aliases
for HOXB13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox B131 2
Homeo Box B131 2
PSGD2
Homeobox Protein Hox-B132

External Ids:    HGNC: 51121   Entrez Gene: 104812   Ensembl: ENSG000001591847   OMIM: 6046075   UniProtKB: Q928263   

Export aliases for HOXB13 gene to outside databases

Previous GC identifers: GC17M046514 GC17M049284 GC17M047145 GC17M047278 GC17M044158 GC17M042171


Summaries
for HOXB13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXB13:
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly
conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play
a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and
spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests
functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the
17q21-22 region. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXB13_HUMAN, Q92826
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB13


Genomic Views
for HOXB13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXB13 gene promoter:
         AML1a   p53   LUN-1   Evi-1   MEF-2A   AREB6   PPAR-gamma1   PPAR-gamma2   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXB13 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXB13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046802:  view genomic region     (about GC identifiers)

Start:
 46,802,125 bp from pter      End:
 46,806,540 bp from pter
Size:
 4,416 bases      Orientation:
 minus strand

Proteins
for HOXB13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXB13_HUMAN, Q92826 (See protein sequence)
Recommended Name: Homeobox protein Hox-B13  
Size: 284 amino acids; 30676 Da
Subcellular location: Nucleus
1 PDB 3D structure from and Proteopedia for HOXB13:
2CRA (3D)    
Secondary accessions: B2R878 Q96QM4 Q99810

Explore the universe of human proteins at neXtProt for HOXB13: NX_Q92826

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92826

    • HOXB13 Protein expression data from MOPED and PaxDb:    About this image 
    HOXB13 Protein Expression
    REFSEQ proteins: NP_006352.2  
    ENSEMBL proteins: 
     ENSP00000290295  

    Human Recombinant Protein Products for HOXB13: 
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    OriGene Protein Over-expression Lysate: HOXB13
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    Novus Biologicals HOXB13 Proteins
    Novus Biologicals HOXB13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXB13

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IEA--

    HOXB13 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HOXB13

    Protein Domains /
    Families
    for HOXB13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXB13 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR022067 HoxA13_N
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry Q92826

    ProtoNet protein and cluster: Q92826

    UniProtKB/Swiss-Prot: HXB13_HUMAN, Q92826
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXB13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXB13_HUMAN, Q92826
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXB13:
    homeo box B13

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXB13 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Hoxb13):
     behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland  integument 
     limbs/digits/tail  nervous system  reproductive system  skeleton 

    HOXB13 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for HOXB13: Hoxb13tm2Mrc Hoxb13tm4Mrc
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOXB13 

    miRNA
    Products:            		 OriGene 3'-UTR Clone: HOXB13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB13
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB13 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-9 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB13 (see all 7)
    OriGene shRNA RFP: HOXB13
    OriGene siRNA: HOXB13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB13
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXB13 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXB13
    Sirion Biotech Customized adenovirus for overexpression of HOXB13 
    Sirion Biotech Customized adenovirus for potent knockdown of HOXB13

    Clone
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    GenScript: all cDNA clones in your preferred vector: HOXB13 (NM_006361)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB13 

    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB13


    Pathways & Interactions
    for HOXB13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of Androgen receptor activity
    		Regulation of Androgen receptor activity1.00


    1 BioSystems Pathway for HOXB13 
        Regulation of Androgen receptor activity


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXB13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for HOXB13 (Q928263 ENSP000002902954) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613, ENSP000003327444I2D: score=2 STRING: ENSP00000332744
    MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
    HOXD4P090163, ENSP000003025484I2D: score=1 STRING: ENSP00000302548
    POU2F1P148593, ENSP000002714114I2D: score=1 STRING: ENSP00000271411
    IRF4Q153063, ENSP000003703434I2D: score=1 STRING: ENSP00000370343
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEP17972163
    GO:0002009morphogenesis of an epithelium ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008544epidermis development TAS9665387
    GO:0009611response to wounding TAS9665387

    HOXB13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXB13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXB13
    Search CenterWatch for drugs/clinical trials and news about HOXB13 / HXB13 

    Transcripts
    for HOXB13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXB13 gene: 
    NM_006361.5  

    Unigene Cluster for HOXB13:

    Homeobox B13
    Hs.66731  [show with all ESTs]
    Unigene Representative Sequence: AY937237
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000290295(uc002ioa.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HOXB13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB13
    8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB13 (see all 33):
    hsa-miR-520e hsa-miR-302d hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-9 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmid: HOXB13 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB13 (see all 7)
    OriGene shRNA RFP: HOXB13
    OriGene siRNA: HOXB13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB13
    Sirion Biotech Custom design and validation of potent shRNA sequences against HOXB13 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXB13 (NM_006361)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB13 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB13
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB13

    Additional cDNA sequence: 

    AK225234.1 AK313266.1 AY937237.1 BC007092.1 BC070233.1 BT007410.1 U57052.1 U81599.1 

    4 DOTS entries:

    DT.113856  DT.120986724  DT.121625890  DT.91754878 

    24/118 AceView cDNA sequences (see all 118):

    AI620785 BF447097 AI378797 BE645544 BQ673782 AA628095 AI655923 BF062550 
    BF057410 AI420106 AI669295 BX090775 BF222357 AI686226 BC070233 CB050115 
    AI804883 BC007092 BE859056 BE388501 BF589565 BT007410 NM_006361 BG778198 

    GeneLoc Exon Structure


    Expression
    for HOXB13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXB13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTCTAACTCC
    HOXB13 Expression
    About this image

    HOXB13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See HOXB13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXB13

    SOURCE GeneReport for Unigene cluster: Hs.66731
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXB13: 
              Stem Cell Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB13

    Orthologs
    for HOXB13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXB13 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXB131 homeobox B13 67.18(n)
    63.18(a)    		   771676  XM_001234926.1  XP_001234927.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXB136
    		 --
    		 72(a)
    		 1 ↔ 1
    		 6(75781126-75781712)
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxb13a1 homeo box B13a 64.31(n)
    66.17(a)    		   559921  NM_001044912.1  NP_001038377.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea nob-16
    		 kNOB-like posterior (NO Backside) family member (n...
    		 13(a)
    		 1 → many
    		 III(12077688-12084220)


    ENSEMBL Gene Tree for HOXB13 (if available)
    TreeFam Gene Tree for HOXB13 (if available) 

    Paralogs
    for HOXB13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXB13 gene
    HOXA92  HOXA132  HOXC92  HOXD112  HOXC122  ENSG000002571842  HOXD102  HOXC112  
    HOXA112  HOXD132  HOXC132  HOXB92  HOXC102  HOXD92  HOXD122  HOXA102  
    7 SIMAP similar genes for HOXB13 using alignment to 2 protein entries:     HXB13_HUMAN (see all proteins):
    MEOX1    HOXC13    HOXA4    HOXB1    HOX B6    HOXA13
    HOXD13

    HOXB13 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXB13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    97/112 NCBI SNPs in HOXB13 are shown (see all 112)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1996079331,2
    		--46801722(+) TGTGT-/GGTGGG 4 -- us2k1 nc-transcript-variantds5001 int10--------
    rs31105991,2
    		C--46801724(-) CCCCCA/CCACAC 4 -- int1 ds5001 nc-transcript-variantus2k14Minor allele frequency- C:0.14CSA WA NA EA 359
    rs1852142561,2
    		--46801855(+) ACCGAA/TCCTCC 4 -- nc-transcript-variantus2k1 int10--------
    rs562905371,2
    		C--46801998(+) CTGTAG/CCTCCG 3 -- us2k1 nc-transcript-variantint12Minor allele frequency- C:0.06WA 120
    rs22718911,2
    		C,F,O,A,H--46802008(-) TCATCC/GTCCGC 2 -- us2k1 int123Minor allele frequency- N:0.00MN EA NA NS WA CSA 1600
    rs80644321,2
    		A,H--46802179(+) AGTTTA/CAGTTT 3 -- ds5001 us2k1 ut314Minor allele frequency- C:0.00NS EA 412
    rs80685661,2
    		A--46802229(+) GAGGTC/TCCAGA 3 -- ut31 us2k1 ds5001 ese30--------
    rs1169319001,2
    		C,F--46802314(+) CAAGGG/TGTCAC 3 -- ds5001 us2k1 ut311Minor allele frequency- T:0.03NA 120
    rs80687321,2
    		A,H--46802316(+) AGGGGT/GCACCC 3 -- ds5001 us2k1 ut31 ese34Minor allele frequency- G:0.00NS EA 418
    rs1454261911,2
    		--46802319(+) GGTCAC/GCCCGC 3 -- ut31 ds5001 us2k10--------
    rs798128611,2
    		F--46802329(+) CACCAT/CGCCGC 3 -- us2k1 ds5001 ut313Minor allele frequency- C:0.05WA NA EA 358
    rs1487912101,2
    		--46802412(+) AGGGAA/GGGGGT 3 -- ut31 ds5001 us2k10--------
    rs1424289861,2
    		--46802533(+) GAAAGC/TGACCT 3 -- ds5001 us2k1 ut310--------
    rs80650281,2
    		A,H--46802535(+) AAGTGA/GCCTGC 3 -- us2k1 ds5001 ut31 ese33Minor allele frequency- G:0.00EA NS 278
    rs80818401,2
    		A--46802539(+) GACCTC/GCTCTG 3 -- ds5001 us2k1 ut31 ese30--------
    rs31072991,2
    		C,F,H--46802561(+) TAACCG/AAGGAC 3 -- ds5001 us2k1 ut31 ese37Minor allele frequency- A:0.01NS EA NA 708
    rs80650511,2
    		A,H--46802580(+) GGACCA/GCGGGG 3 -- ds5001 us2k1 ut31 ese34Minor allele frequency- G:0.00NS EA 418
    rs80692691,2
    		A,H--46802669(+) TGCACT/CCACAC 2 -- ut31 us2k1 ese34Minor allele frequency- C:0.00NS EA 418
    rs1895893651,2
    		--46802973(+) CCAGAC/TTTCAG 2 -- us2k1 ut310--------
    rs1840537511,2
    		--46803261(+) CACCAA/CTCTGC 2 -- us2k1 ut310--------
    rs1135683401,2
    		C--46803290(+) GAAGGA/GCTAAG 2 -- us2k1 ut310--------
    rs116536111,2
    		C,F,A,H--46803538(+) GGGTGC/TTTCCA 2 -- us2k1 ut318Minor allele frequency- T:0.27NA EA 254
    rs1442414881,2
    		--46803606(+) AATTGC/TCCACC 2 -- us2k1 ut310--------
    rs1870030571,2
    		--46803631(+) CTGAGA/TAAAAT 2 -- us2k1 ut310--------
    rs799824431,2
    		--46803709(+) CCAGGG/CTGAGA 2 -- ut31 us2k11Minor allele frequency- C:0.01NA 120
    rs1465529061,2
    		--46803832(+) TCTAGA/GTAGAA 2 -- ut31 us2k10--------
    rs22803541,2
    		C,F,H--46803833(-) TTTCTA/GTCTAG 2 -- ut31 us2k19Minor allele frequency- G:0.04NS EA NA 858
    rs22803531,2
    		C,H--46803851(-) TGATCG/ATTAGC 1 -- ut31 ese35Minor allele frequency- A:0.00NS EA 536
    rs1922444271,2
    		--46803939(+) CCCTGC/GTGGAG 1 -- ut310--------
    rs1836209201,2
    		--46804037(+) AAGGGC/TGTTGT 1 -- ut310--------
    rs1874428391,2
    		--46804081(+) AGCCTG/TGGCTT 1 -- ut310--------
    rs1411795921,2
    		--46804095(+) AGGTTC/TCTGGT 1 -- ut310--------
    rs1449675041,2
    		--46804098(+) TTCCTC/GGTCTC 1 -- ut310--------
    rs771798531,2
    		C--46804154(+) TCTTA-/AGGGGT 2 K * fra10--------
    rs2009973841,2
    		C--46804175(+) CTTCAA/CCTTGG 2 V L mis10--------
    rs1918869301,2
    		C--46804181(+) CTTGGC/TGAGAA 2 T A mis10--------
    rs1386751881,2
    		C,F--46804272(+) CGCCTC/TTTGTC 2 K syn11Minor allele frequency- T:0.00NA 4552
    rs2003620931,2
    		--46804329(+) AACTGC/TCCCTT 2 G syn10--------
    rs1394757911,2
    		C,F--46804358(+) CTTGCG/AGCCGC 2 /R /C mis11Minor allele frequency- A:0.00NA 4552
    rs1489013311,2
    		C--46804414(+) CGCGGC/TGTGAA 1 -- int11Minor allele frequency- T:0.00EU 1321
    rs1435566171,2
    		C--46804427(+) GGAGGA/GAGGAA 1 -- int10--------
    rs728318461,2
    		--46804595(+) ACCACC/TGCTCA 1 -- int10--------
    rs24117961,2
    		C,F,H--46804740(-) GAGTGG/ACCAAG 1 -- int118Minor allele frequency- A:0.10NS EA NA WA 2336
    rs1825503041,2
    		--46804753(+) TTAGAC/TTCTAC 1 -- int10--------
    rs121037771,2
    		C,H--46804789(+) GCCCCC/AACTCC 1 -- int14Minor allele frequency- A:0.00NS EA 418
    rs1398873101,2
    		C--46804808(+) CGCAT-/ACACACA 1 -- int10--------
    rs351198641,2
    		C--46804827(+) ACACA-/CATTAAC 1 -- int10--------
    rs169700031,2
    		C,F--46804892(+) GGAAAT/CTGGAA 1 -- int14Minor allele frequency- C:0.03NA EA 262
    rs1868754811,2
    		--46804982(+) CCCACA/GCACCG 1 -- int10--------
    rs1921481051,2
    		--46805002(+) TTATTC/TAGCTT 1 -- int10--------
    rs98991421,2
    		C,F,H--46805221(+) AGAGTC/TCTAAT 1 -- int125Minor allele frequency- T:0.17NS EA NA WA CSA 2768
    rs1435479551,2
    		--46805297(+) AAATGC/TCATTG 1 -- int10--------
    rs2006067001,2
    		F--46805306(+) TGGGAC/TCCACA 1 -- int11Minor allele frequency- T:0.00EU 1133
    rs1439450911,2
    		C--46805389(+) GGTGGG/ATTCTG 2 /N syn11Minor allele frequency- A:0.00NA 4552
    rs99006271,2
    		C,F,A,H--46805443(+) GCCCAA/GGACTG 2 S syn120Minor allele frequency- G:0.10EA NA NS CSA WA EU 6874
    rs1995613051,2
    		--46805467(+) GGCAAC/GAGGGA 2 L syn10--------
    rs350332731,2
    		C,F--46805482(-) GAACCG/ACGACA 2 /P syn12Minor allele frequency- A:0.00NA 4630
    rs2014280951,2
    		--46805588(+) TGGGGC/TGGCTG 2 H R mis10--------
    rs85561,2
    		C,F,H--46805590(-) CCCAGC/TCGCCC 2 S syn1 ese323Minor allele frequency- T:0.17MN NS EA NA WA CSA EU 8486
    rs339931861,2
    		C,F--46805626(-) TACCCC/AGCGGA 2 /P syn15Minor allele frequency- A:0.01NA CSA WA EU 5688
    rs1382131971,2
    		C,F--46805705(+) CGCCTC/TCAAAG 2 E G mis12Minor allele frequency- T:0.00NA EU 5183
    rs115518921,2
    		H--46805811(-) ACTATG/CCCCCC 2 /P /A mis14Minor allele frequency- C:0.00NS EA 404
    rs1997997431,2
    		--46805834(+) TCAGCA/GTAGGC 2 T M mis10--------
    rs793445051,2
    		C--46805859(+) GGTCAG/TAGGGG 2 M L mis10--------
    rs1471577481,2
    		--46806104(+) TCTTGA/GCGCAA 1 -- ut510--------
    rs1423385031,2
    		--46806216(+) CTTAT-/TCTCTCT 1 -- us2k10--------
    rs1419881731,2
    		--46806238(+) CTCTT-/TCTCTCT 1 -- us2k10--------
    rs1932512041,2
    		--46806300(+) CGCTCC/TTTCTC 1 -- us2k10--------
    rs80674641,2
    		A,H--46806549(+) CTTTGA/GCAGGT 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs80657841,2
    		A--46806564(+) CGAGAA/GAATAA 1 -- us2k10--------
    rs80659211,2
    		A--46806619(+) GTCGGA/GGGTGG 1 -- us2k10--------
    rs1844425911,2
    		--46806822(+) GGTGCC/TCTGGA 1 -- us2k10--------
    rs80775961,2
    		A,H--46806867(+) TGCTCT/AGGAGG 1 -- us2k14Minor allele frequency- A:0.00NS EA 412
    rs38097721,2
    		H--46806915(-) CTACGT/ATCGTG 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs13202831,2
    		C,F,A,H--46807134(-) TGTCAG/ACTTCT 1 -- us2k1 tfbs330Minor allele frequency- A:0.48EA NA NS WA CSA 2782
    rs99022861,2
    		C,A,H--46807401(+) CCCACA/CCAAGC 1 -- us2k14Minor allele frequency- C:0.00NS EA 408
    rs1162998871,2
    		--46807410(+) GCTGAG/ATACCC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1812573071,2
    		--46807465(+) CCTTAC/TAAGGA 1 -- us2k10--------
    rs287272971,2
    		--46807496(+) CCCCAA/GCCACT 1 -- us2k1 tfbs30--------
    rs1155001461,2
    		F--46807508(+) GCAGAA/CTTGCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1427135351,2
    		--46807530(+) TGTTGA/GGGCCT 1 -- us2k10--------
    rs1881828941,2
    		--46807550(+) TGCAAA/TTCAGA 1 -- us2k10--------
    rs1507180581,2
    		--46807673(+) GGAGAA/GGACAG 1 -- us2k10--------
    rs1810313911,2
    		--46807751(+) ACTCAA/GTCATA 1 -- us2k10--------
    rs1400280181,2
    		--46807761(+) AGCCTC/GTCACC 1 -- us2k10--------
    rs1498406261,2
    		--46807876(+) TCTTCA/GCTAGA 1 -- us2k10--------
    rs38097711,2
    		C,F,H--46807919(-) GAGACA/GTCTCC 1 -- us2k112Minor allele frequency- G:0.03EA NS NA 3124
    rs1860638781,2
    		--46808006(+) TAAAGA/CCTAAG 1 -- us2k10--------
    rs2017800921,2
    		----46805374(+) TTCCAA/GAAGGG 2 F syn11Minor allele frequency- G:0.00EU 1285
    rs1998131551,2
    		----46805768(+) GGTGGC/TATTGC 2 Y C mis10--------
    rs1504133961,2
    		----46805653(+) GCCTGG/CGCACA 2 /A syn11Minor allele frequency- C:0.00NA 4144
    rs767654401,2
    		----46806237(+) TCTCTC/TTCTCT 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs611238251,2
    		----46802359(+) CCCCTC/TCCCAC 3 -- ut31 ds5001 us2k10--------
    rs721136111,2
    		----46806264(+) TCTGT-/TCTCTG
                CTCTG     		1 -- us2k10--------
    rs1486493901,2
    		----46805433(+) ACCAGC/AGAGAG 2 /A /S mis11Minor allele frequency- A:0.00NA 4552
    rs792148671,2
    		----46803236(+) ACGTGG/AACTGG 2 -- us2k1 ut311Minor allele frequency- A:0.50NA 2
    rs617489761,2
    		----46805996(+) GGAATC/TTAGGG 1 -- ut511Minor allele frequency- T:0.03NS 38

    HapMap Linkage Disequilibrium report for HOXB13 (46802125 - 46806540 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HOXB13
         1 CNV: 4040
    Human Gene Mutation Database (HGMD): HOXB13

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB13
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXB13

    Disorders / Diseases
    for HOXB13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXB13 for disorders           About GeneDecksing

    OMIM gene information: 604607    OMIM disorders: --

    13 diseases for HOXB13:    About MalaCards
    myxopapillary ependymoma    renal cell carcinoma    ependymoma    endometrial cancer
    cervical carcinoma    cervicitis    ovarian cancer    colorectal cancer
    prostate cancer    breast cancer    carcinoma    prostatitis
    melanoma

    2 diseases from the University of Copenhagen DISEASES database for HOXB13:
    Spinal cord ependymoma     Prostate cancer
    Human Genome Epidemiology (HuGE) Navigator: HOXB13 (1 document)

    Export disorders for HOXB13 gene to outside databases

    Publications
    for HOXB13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXB13 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with HOXB13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PubMed id 9665387)1, 2, 3 Stelnicki E.J....Largman C. (1998)
    2. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. (PubMed id 8756292)1, 2, 3 Zeltser L.M.... Heintz N. (1996)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (2002)
    5. Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer. (PubMed id 18499701)1, 9 Rodriguez B.A....Huang T.H. (2008)
    6. HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. (PubMed id 12761847)1, 9 Komuves L.G....Largman C. (2003)
    7. Association of a HOXB13 variant with breast cancer. (PubMed id 22853031)1 Alanee S....Offit K. (2012)
    8. Germline mutations in HOXB13 and prostate-cancer risk . (PubMed id 22236224)1 Ewing C.M....Cooney K.A. (2012)
    9. Association between germline HOXB13 G84E mutation and risk of prostate cancer. (PubMed id 22781434)1 Akbari M.R....Nam R.K. (2012)
    10. A Hoxb13-driven reverse tetracycline transactivator sy stem for conditional gene expression in the prostate. (PubMed id 22297979)1 Rao V....Bieberich C.J. (2012)

    External Searches for HOXB13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXB13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10481 HGNC: 5112 AceView: HOXB13 Ensembl:ENSG00000159184 euGenes: HUgn10481
    ECgene: HOXB13 H-InvDB: HOXB13

    Other Databases showing HOXB13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXB13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXB13 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXB13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXB13 gene:
    Search GeneIP for patents involving HOXB13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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