HOXB13 Gene

Aliases
for HOXB13 gene

Previous GC identifers: GC17M046514 GC17M049284 GC17M047145 GC17M047278 GC17M044158 GC17M042171

Summaries
for HOXB13 gene

Genomic Views
for HOXB13 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010783.15  

SwitchGear Promoter luciferase reporter plasmid: HOXB13 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB13

HOXB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046802:  view genomic region     (about GC identifiers)

Proteins
for HOXB13 gene

1 PDB 3D structure from and Proteopedia for HOXB13:

2CRA (3D)    

Explore the universe of human proteins at neXtProt for HOXB13: NX_Q92826

Post-translational modifications:

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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: HOXB13 OriGene Custom Protein Services for HOXB13
	GenScript Custom Purified and Recombinant Proteins Services for HOXB13
	Novus Biologicals HOXB13 Proteins Novus Biologicals HOXB13 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HOXB13

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

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	OriGene Antibodies: HOXB13 OriGene Custom Antibody Services for HOXB13
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	Uscn Antibodies for HOXB13
	ThermoFisher Antibodies for HOXB13

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for HOXB13
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HOXB13

Protein Domains /
Families
for HOXB13 gene

ProtoNet protein and cluster: Q92826

Function
for HOXB13 gene

miRNA Products:		OriGene 3'-UTR Clone: HOXB13 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXB13
		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB13 (see all 33):
		hsa-miR-520e hsa-miR-302d hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-9 hsa-miR-372 hsa-miR-93
		SwitchGear 3'UTR luciferase reporter plasmid: HOXB13 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB13 (see all 7) OriGene shRNA RFP: HOXB13 OriGene siRNA: HOXB13
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXB13

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HOXB13

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB13 (see first 1) NM_006361 (human cat#: RC209991)  NM_008267 (mouse cat#: MR203892)  NM_001107041 (rat cat#: RR203606)   OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXB13 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HOXB13 (NM_006361)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB13
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB13

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HOXB13
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB13

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 4 alleles) (MGI details for Hoxb13)

Pathways & Interactions
for HOXB13 gene

	Super-pathway	contained gene-specific pathways
1	Regulation of Androgen receptor activity	Regulation of Androgen receptor activity 1.00

1 BioSystems Pathway for HOXB13

Regulation of Androgen receptor activity

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for HOXB13 gene

Transcripts
for HOXB13 gene

Expression
for HOXB13 gene

HOXB13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTAACTCC

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor Cells			Spinal Cord
	Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor Cells			Motor Neurons
	Spinal CordSpinal Dorsal Columns			Spinal Cord
	Spinal CordSpinal Ventral Columns			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXB13 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXB13
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXB13
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXB13

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB13

Orthologs
for HOXB13 gene

Paralogs
for HOXB13 gene

Paralogs for HOXB13 gene

HOXA9²  HOXA13²  HOXC9²  HOXD11²  HOXC12²  ENSG00000257184²  HOXD10²  HOXC11²  

HOXA11²  HOXD13²  HOXC13²  HOXB9²  HOXC10²  HOXD9²  HOXD12²  HOXA10²  

7 SIMAP similar genes for HOXB13 using alignment to 2 protein entries:     HXB13_HUMAN (see all proteins):

MEOX1    HOXC13    HOXA4    HOXB1    HOX B6    HOXA13

HOXD13

HOXB13 for paralogs           About GeneDecksing

Genomic Variants
for HOXB13 gene

10/112 NCBI SNPs in HOXB13 are shown (see all 112)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1996079331,2		--	46801722(+)	TGTGT-/GGTGGG	4	--	us2k1 nc-transcript-variantds5001 int1		0	--	--	--	--
rs31105991,2	C,	--	46801724(-)	CCCCCA/CCACAC	4	--	int1 ds5001 nc-transcript-variantus2k1		4		CSA WA NA EA	359
rs1852142561,2		--	46801855(+)	ACCGAA/TCCTCC	4	--	nc-transcript-variantus2k1 int1		0	--	--	--	--
rs562905371,2	C,	--	46801998(+)	CTGTAG/CCTCCG	3	--	us2k1 nc-transcript-variantint1		2		WA	120
rs22718911,2	C,F,O,A,H,	--	46802008(-)	TCATCC/GTCCGC	2	--	us2k1 int1		23		MN EA NA NS WA CSA	1600
rs80644321,2	A,H	--	46802179(+)	AGTTTA/CAGTTT	3	--	ds5001 us2k1 ut31		4		NS EA	412
rs80685661,2	A	--	46802229(+)	GAGGTC/TCCAGA	3	--	ut31 us2k1 ds5001 ese3		0	--	--	--	--
rs1169319001,2	C,F,	--	46802314(+)	CAAGGG/TGTCAC	3	--	ds5001 us2k1 ut31		1		NA	120
rs80687321,2	A,H	--	46802316(+)	AGGGGT/GCACCC	3	--	ds5001 us2k1 ut31 ese3		4		NS EA	418
rs1454261911,2		--	46802319(+)	GGTCAC/GCCCGC	3	--	ut31 ds5001 us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for HOXB13 (46802125 - 46806540 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HOXB13
     1 CNV: 4040
Human Gene Mutation Database (HGMD): HOXB13

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB13

DNA2.0 Custom Variant and Variant Library Synthesis for HOXB13

Disorders / Diseases
for HOXB13 gene

Publications
for HOXB13 gene

PubMed articles for HOXB13 gene, integrated from 9 sources (see all 38): (articles sorted by number of sources associating them with HOXB13)

Utopia: connect your pdf to the dynamic world of online information

1. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PubMed id 9665387)^{1, 2, 3} Stelnicki E.J....Largman C. (1998)
2. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. (PubMed id 8756292)^{1, 2, 3} Zeltser L.M.... Heintz N. (1996)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)^{1, 2} Kosaki K.... Matsuo N. (2002)
5. Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer. (PubMed id 18499701)^{1, 9} Rodriguez B.A....Huang T.H. (2008)
6. HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. (PubMed id 12761847)^{1, 9} Komuves L.G....Largman C. (2003)
7. Association of a HOXB13 variant with breast cancer. (PubMed id 22853031)¹ Alanee S....Offit K. (2012)
8. Germline mutations in HOXB13 and prostate-cancer risk . (PubMed id 22236224)¹ Ewing C.M....Cooney K.A. (2012)
9. Association between germline HOXB13 G84E mutation and risk of prostate cancer. (PubMed id 22781434)¹ Akbari M.R....Nam R.K. (2012)
10. A Hoxb13-driven reverse tetracycline transactivator sy stem for conditional gene expression in the prostate. (PubMed id 22297979)¹ Rao V....Bieberich C.J. (2012)

External Searches for HOXB13 gene

Genome Databases showing HOXB13 gene

Other Databases showing HOXB13 gene

Specialized Databases showing HOXB13 gene

Products
for HOXB13 gene