HOXB13 Gene

Aliases
for HOXB13 gene

Previous GC identifers: GC17M046514 GC17M049284 GC17M047145 GC17M047278 GC17M044158 GC17M042171

Summaries
for HOXB13 gene

Genomic Views
for HOXB13 gene

RefSeq DNA sequence:

NC_000017.10  NC_018928.1  NT_010783.15  

SwitchGear Promoter luciferase reporter plasmid: HOXB13 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXB13

HOXB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046802:  view genomic region     (about GC identifiers)

Proteins
for HOXB13 gene

1 PDB 3D structure from and Proteopedia for HOXB13:

2CRA (3D)    

Explore the universe of human proteins at neXtProt for HOXB13: NX_Q92826

Post-translational modifications:

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	Novus Biologicals HOXB13 Proteins Novus Biologicals HOXB13 Lysate
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	Uscn Proteins for HOXB13

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

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	Uscn Antibodies for HOXB13
	ThermoFisher Antibodies for HOXB13

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	Uscn ELISAs and CLIAs for HOXB13

Protein Domains /
Families
for HOXB13 gene

ProtoNet protein and cluster: Q92826

Function
for HOXB13 gene

miRNA Products:		OriGene 3'-UTR Clone: HOXB13 Browse MicroRNA Expression Plasmids
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		8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXB13 (see all 33):
		hsa-miR-520e hsa-miR-302d hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-9 hsa-miR-372 hsa-miR-93
		SwitchGear 3'UTR luciferase reporter plasmid: HOXB13 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXB13 (see all 7) OriGene shRNA RFP: HOXB13 OriGene siRNA: HOXB13
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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HOXB13

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB13

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

(inferred from 4 alleles) (MGI details for Hoxb13)

Pathways & Interactions
for HOXB13 gene

	Super-pathway	contained gene-specific pathways
1	Regulation of Androgen receptor activity	Regulation of Androgen receptor activity 1.00

1 BioSystems Pathway for HOXB13

Regulation of Androgen receptor activity

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for HOXB13 gene

Transcripts
for HOXB13 gene

Expression
for HOXB13 gene

HOXB13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTAACTCC

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor Cells			Spinal Cord
	Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor Cells			Motor Neurons
	Spinal CordSpinal Dorsal Columns			Spinal Cord
	Spinal CordSpinal Ventral Columns			Spinal Cord
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB13

Orthologs
for HOXB13 gene

Paralogs
for HOXB13 gene

Paralogs for HOXB13 gene

HOXA9²  HOXA13²  HOXC9²  HOXD11²  HOXC12²  ENSG00000257184²  HOXD10²  HOXC11²  

HOXA11²  HOXD13²  HOXC13²  HOXB9²  HOXC10²  HOXD9²  HOXD12²  HOXA10²  

7 SIMAP similar genes for HOXB13 using alignment to 2 protein entries:     HXB13_HUMAN (see all proteins):

MEOX1    HOXC13    HOXA4    HOXB1    HOX B6    HOXA13

HOXD13

HOXB13 for paralogs           About GeneDecksing

Genomic Variants
for HOXB13 gene

10/112 NCBI SNPs in HOXB13 are shown (see all 112)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1996079331,2		--	46801722(+)	TGTGT-/GGTGGG	4	--	us2k1 nc-transcript-variantds5001 int1		0	--	--	--	--
rs31105991,2	C,	--	46801724(-)	CCCCCA/CCACAC	4	--	int1 ds5001 nc-transcript-variantus2k1		4		CSA WA NA EA	359
rs1852142561,2		--	46801855(+)	ACCGAA/TCCTCC	4	--	nc-transcript-variantus2k1 int1		0	--	--	--	--
rs562905371,2	C,	--	46801998(+)	CTGTAG/CCTCCG	3	--	us2k1 nc-transcript-variantint1		2		WA	120
rs22718911,2	C,F,O,A,H,	--	46802008(-)	TCATCC/GTCCGC	2	--	us2k1 int1		23		MN EA NA NS WA CSA	1600
rs80644321,2	A,H	--	46802179(+)	AGTTTA/CAGTTT	3	--	ds5001 us2k1 ut31		4		NS EA	412
rs80685661,2	A	--	46802229(+)	GAGGTC/TCCAGA	3	--	ut31 us2k1 ds5001 ese3		0	--	--	--	--
rs1169319001,2	C,F,	--	46802314(+)	CAAGGG/TGTCAC	3	--	ds5001 us2k1 ut31		1		NA	120
rs80687321,2	A,H	--	46802316(+)	AGGGGT/GCACCC	3	--	ds5001 us2k1 ut31 ese3		4		NS EA	418
rs1454261911,2		--	46802319(+)	GGTCAC/GCCCGC	3	--	ut31 ds5001 us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for HOXB13 (46802125 - 46806540 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HOXB13
     1 CNV: 4040
Human Gene Mutation Database (HGMD): HOXB13

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXB13

DNA2.0 Custom Variant and Variant Library Synthesis for HOXB13

Disorders / Diseases
for HOXB13 gene

Publications
for HOXB13 gene

PubMed articles for HOXB13 gene, integrated from 9 sources (see all 38) (see top 10): (articles sorted by number of sources associating them with HOXB13)

Utopia: connect your pdf to the dynamic world of online information

1. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PubMed id 9665387)^{1, 2, 3} Stelnicki E.J....Largman C. (1998)
2. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. (PubMed id 8756292)^{1, 2, 3} Zeltser L.M.... Heintz N. (1996)
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
4. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)^{1, 2} Kosaki K.... Matsuo N. (2002)
5. Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer. (PubMed id 18499701)^{1, 9} Rodriguez B.A....Huang T.H. (2008)
6. HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. (PubMed id 12761847)^{1, 9} Komuves L.G....Largman C. (2003)
7. Association of a HOXB13 variant with breast cancer. (PubMed id 22853031)¹ Alanee S....Offit K. (2012)
8. Germline mutations in HOXB13 and prostate-cancer risk . (PubMed id 22236224)¹ Ewing C.M....Cooney K.A. (2012)
9. Association between germline HOXB13 G84E mutation and risk of prostate cancer. (PubMed id 22781434)¹ Akbari M.R....Nam R.K. (2012)
10. A Hoxb13-driven reverse tetracycline transactivator sy stem for conditional gene expression in the prostate. (PubMed id 22297979)¹ Rao V....Bieberich C.J. (2012)
11. Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classificati on. (PubMed id 21574054)¹ Chong L.Y....Tan P.H. (2012)
12. HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling. (PubMed id 20504375)¹ Kim Y.R....Jung C. (2010)
13. Predictive relevance of HOXB13 protein expression for tamoxifen benefit in breast cancer. (PubMed id 20649975)¹ Jerevall P.L....StAYl O. (2010)
14. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)¹ Ravasi T....Hayashizaki Y. (2010)
15. A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland. (PubMed id 20018680)¹ McMullin R.P....Bieberich C.J. (2010)
16. HOXB13, a target of DNMT3B, is methylated at an upstr eam CpG island, and functions as a tumor suppressor in primary colorectal tumor s. (PubMed id 20454457)¹ Ghoshal K....Jacob S.T. (2010)
17. HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. (PubMed id 17972163)¹ Chung N....Rha H.K. (2009)
18. The homeodomain protein HOXB13 regulates the cellular response to androgens. (PubMed id 19917249)¹ Norris J.D....McDonnell D.P. (2009)
19. Functional characterization of the HOXB13 promoter region. (PubMed id 18163187)¹ Cross D.S. and Burmester J.K. (2008)
20. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. (PubMed id 18794098)¹ Goetz M.P....Ingle J.N. (2008)
21. Exploring the two-gene ratio in breast cancer--independent roles for HOXB13 and IL17BR in prediction of clinical outcome. (PubMed id 17453342)¹ Jerevall P.L....StAYl O. (2008)
22. The prognostic biomarkers HOXB13, IL17BR, and CHDH are regulated by estrogen in breast cancer. (PubMed id 17975144)¹ Wang Z....Sgroi D.C. (2007)
23. HOXB13 promotes ovarian cancer progression. (PubMed id 17942676)¹ Miao J....Orsulic S. (2007)
24. The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. (PubMed id 17008703)¹ Ma X.J....Erlander M.G. (2006)
25. Genomic testing for sensitivity of breast cancer to hormonal therapy. (PubMed id 16609001)¹ Symmans W.F. (2006)
26. Epigenetic silencing of novel tumor suppressors in malignant melanoma. (PubMed id 17145863)¹ Muthusamy V....Bosenberg M. (2006)
27. A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. (PubMed id 16609019)¹ Goetz M.P....Couch F.J. (2006)
28. The homeobox HOXB13 is expressed in human minor salivary gland. (PubMed id 16792730)¹ Cazal C....Nunes F.D. (2006)
29. HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation. (PubMed id 15928669)¹ Jung C....Kao C. (2005)
30. Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer. (PubMed id 15756448)¹ Zhao Y....Ishikawa M. (2005)
31. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. (PubMed id 15126340)¹ Jung C....Jeng M.H. (2004)
32. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
33. HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. (PubMed id 15604291)¹ Jung C....Jeng M.H. (2004)
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
35. AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins. (PubMed id 9343407)¹ Shen W.F....Largman C. (1997)

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