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HOXB13 Gene

protein-coding   GIFtS: 58
GCID: GC17M046802

Homeobox B13

(Previous name: homeo box B13)
  See HOXB13-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox B131 2
Homeo Box B131
PSGD2
Homeobox Protein Hox-B132

External Ids:    HGNC: 51121   Entrez Gene: 104812   Ensembl: ENSG000001591847   OMIM: 6046075   UniProtKB: Q928263   

Export aliases for HOXB13 gene to outside databases

Previous GC identifers: GC17M046514 GC17M049284 GC17M047145 GC17M047278 GC17M044158 GC17M042171


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXB13 Gene:
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly
conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to
play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit
temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary
axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene
cluster at chromosome the 17q21-22 region. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXB13 Gene:
HOXB13 (homeobox B13) is a protein-coding gene. Diseases associated with HOXB13 include spinal cord ependymoma, and familial prostate cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot: HXB13_HUMAN, Q92826
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXB13 gene promoter:
         AML1a   p53   LUN-1   Evi-1   MEF-2A   AREB6   PPAR-gamma1   PPAR-gamma2   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXB13 promoter sequence
   Search Chromatin IP Primers for HOXB13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXB13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2   Ensembl cytogenetic band:  17q21.32   HGNC cytogenetic band: 17q21.32

HOXB13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXB13 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M046802:  view genomic region     (about GC identifiers)

Start:
46,802,125 bp from pter      End:
46,806,540 bp from pter
Size:
4,416 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HXB13_HUMAN, Q92826 (See protein sequence)
Recommended Name: Homeobox protein Hox-B13  
Size: 284 amino acids; 30676 Da
1 PDB 3D structure from and Proteopedia for HOXB13:
2CRA (3D)    
Secondary accessions: B2R878 Q96QM4 Q99810

Explore the universe of human proteins at neXtProt for HOXB13: NX_Q92826

Explore proteomics data for HOXB13 at MOPED


See HOXB13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_006352.2  
ENSEMBL proteins: 
 ENSP00000290295  

HOXB13 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for HOXB13

 
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antibodies-online proteins for HOXB13 (5 products) 

 
antibodies-online peptides for HOXB13

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antibodies-online antibodies for HOXB13 (45 products) 

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Cloud-Clone Corp. ELISAs for HOXB13
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antibodies-online kits for HOXB13 (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

4 InterPro protein domains:
 IPR022067 HoxA13_N
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q92826

ProtoNet protein and cluster: Q92826

UniProtKB/Swiss-Prot: HXB13_HUMAN, Q92826
Similarity: Belongs to the Abd-B homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with HOXB13           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HXB13_HUMAN, Q92826
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

     Genatlas biochemistry entry for HOXB13:
homeo box B13

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding ----
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with HOXB13           About GenesLikeMe


Phenotypes:
     9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hoxb13):
 behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland  integument 
 limbs/digits/tail  nervous system  reproductive system  skeleton 

Find genes that share phenotypes with HOXB13           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for HOXB13: Hoxb13tm2Mrc Hoxb13tm4Mrc

   genOway: Develop your customized and physiologically relevant rodent model for HOXB13

miRNA
Products:
    
miRTarBase miRNAs that target HOXB13:
hsa-mir-375 (MIRT019730)

Block miRNA regulation of human, mouse, rat HOXB13 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HOXB13 (see all 33):
hsa-miR-520e hsa-miR-302d hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-9 hsa-miR-372 hsa-miR-93
SwitchGear 3'UTR luciferase reporter plasmidHOXB13 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for HOXB13
Predesigned siRNA for gene silencing in human, mouse, rat HOXB13

Gene Editing
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DNA2.0 Custom Protein Engineering Service for HOXB13

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OriGene clones in human, mouse for HOXB13 (see all 6)
OriGene ORF clones in mouse, rat for HOXB13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXB13 (NM_006361)
Sino Biological Human cDNA Clone for HOXB13
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB13
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB13
Addgene plasmids for HOXB13 

Cell Line
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Browse ESI BIO Cell Lines and PureStem Progenitors for HOXB13 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB13

Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA1-12423) for HOXB13 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HXB13_HUMAN, Q92826: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA--
GO:0005667transcription factor complex IEA--
GO:0005730NOT nucleolus IDA--

Find genes that share ontologies with HOXB13           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for HOXB13 About    
See pathways by source

SuperPathContained pathways About
1Regulation of Androgen receptor activity
Regulation of Androgen receptor activity


1 BioSystems Pathway for HOXB13
    Regulation of Androgen receptor activity



    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXB13: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for HOXB13

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

Selected Interacting proteins for HOXB13 (Q928263 ENSP000002902954) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
ALX4Q9H1613, ENSP000003327444I2D: score=2 STRING: ENSP00000332744
MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
HOXD4P090163, ENSP000003025484I2D: score=1 STRING: ENSP00000302548
POU2F1P148593, ENSP000002714114I2D: score=1 STRING: ENSP00000271411
IRF4Q153063, ENSP000003703434I2D: score=1 STRING: ENSP00000370343
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Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001525angiogenesis IEP17972163
GO:0002009morphogenesis of an epithelium ----
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0008544epidermis development TAS9665387

Find genes that share ontologies with HOXB13           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HOXB13 (HXB13)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HOXB13 gene: 
NM_006361.5  

Unigene Cluster for HOXB13:

Homeobox B13
Hs.66731  [show with all ESTs]
Unigene Representative Sequence: AY937237
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000290295(uc002ioa.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat HOXB13 using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate HOXB13 (see all 33):
hsa-miR-520e hsa-miR-302d hsa-miR-1224-3p hsa-miR-106a hsa-miR-1260b hsa-miR-9 hsa-miR-372 hsa-miR-93
SwitchGear 3'UTR luciferase reporter plasmidHOXB13 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HOXB13
Predesigned siRNA for gene silencing in human, mouse, rat HOXB13
Clone
Products:
     
OriGene clones in human, mouse for HOXB13 (see all 6)
OriGene ORF clones in mouse, rat for HOXB13
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: HOXB13 (NM_006361)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXB13
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXB13
Addgene plasmids for HOXB13 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HOXB13
OriGene qSTAR qPCR primer pairs in human, mouse for HOXB13
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXB13
  QuantiTect SYBR Green Assays in human, mouse, rat HOXB13
  QuantiFast Probe-based Assays in human, mouse, rat HOXB13
Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA1-12423) for HOXB13 

Additional mRNA sequence: 

AK225234.1 AK313266.1 AY937237.1 BC007092.1 BC070233.1 BT007410.1 U57052.1 U81599.1 

4 DOTS entries:

DT.113856  DT.120986724  DT.121625890  DT.91754878 

Selected AceView cDNA sequences (see all 118):

AI669295 AI420106 BF447097 AI378797 AI686226 AI804883 AI620785 BF062550 
BF222357 BE388501 BE859056 AI655923 AA628095 BX090775 BE645544 BQ673782 
BF589565 BC007092 CB050115 BC070233 BF057410 AI821103 AU149674 AI417272 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HOXB13 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCTAACTCC
HOXB13 Expression
About this image


HOXB13 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 2 entries
         Spinal Ventral Columns
 
 Gut Tube (Gastrointestinal Tract)
         Hindgut
 
 Colon (Gastrointestinal Tract)
 
 Prostate (Endocrine System)
HOXB13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HOXB13 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.66731
    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXB13: 
          Stem Cell Transcription Factors in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for HOXB13
OriGene qSTAR qPCR primer pairs in human, mouse for HOXB13
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QuantiFast Probe-based Assays in human, mouse, rat HOXB13
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXB13

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for HOXB13 gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hoxb131 , 5 homeobox B131, 5 87.56(n)1
93.66(a)1
  11 (59.63 cM)5
154081  NM_008267.31  NP_032293.11 
 961943165 
chicken
(Gallus gallus)
Aves HOXB131 homeobox B13 67.06(n)
62.65(a)
  771676  XM_001234926.2  XP_001234927.1 
lizard
(Anolis carolinensis)
Reptilia HOXB136
homeobox B13
72(a)
1 ↔ 1
6(75781126-75781712)
zebrafish
(Danio rerio)
Actinopterygii hoxb13a1 homeo box B13a 64.31(n)
66.17(a)
  559921  NM_001044912.1  NP_001038377.1 
fruit fly
(Drosophila melanogaster)
Insecta Abd-B6
Abdominal B
15(a)
1 → many
3R(12752932-12797958)


ENSEMBL Gene Tree for HOXB13 (if available)
TreeFam Gene Tree for HOXB13 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HOXB13 gene
HOXD112  ENSG000002571842  HOXD102  HOXC132  HOXC102  HOXD122  HOXA92  HOXA132  
HOXC92  HOXC122  HOXC112  HOXD132  HOXA112  HOXB92  HOXD92  HOXA102  
6 SIMAP similar genes for HOXB13 using alignment to 3 protein entries:     HXB13_HUMAN (see all proteins):
HOXC13    HOXA4    HOXB1    HOX B6    HOXA13    HOXD13

Find genes that share paralogs with HOXB13           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HOXB13 (see all 103)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs22803531,2
C,F,H--46803851(-) TGATCG/ATTAGC 1 -- ut31 ese35Minor allele frequency- A:0.00NS EA 536
rs1922444271,2
--46803939(+) CCCTGC/GTGGAG 1 -- ut310--------
rs1836209201,2
--46804037(+) AAGGGC/TGTTGT 1 -- ut310--------
rs1874428391,2
--46804081(+) AGCCTG/TGGCTT 1 -- ut310--------
rs1411795921,2
--46804095(+) AGGTTC/TCTGGT 1 -- ut310--------
rs1449675041,2
--46804098(+) TTCCTC/GGTCTC 1 -- ut310--------
rs771798531,2
C--46804154(+) TCTTA-/AGGGGT 2 K * fra10--------
rs2009973841,2
C--46804175(+) CTTCAA/CCTTGG 2 V L mis10--------
rs1918869301,2
C--46804181(+) CTTGGC/TGAGAA 2 T A mis10--------
rs1386751881,2
C,F--46804272(+) CGCCTC/TTTGTC 2 K syn11Minor allele frequency- T:0.00NA 4552

HapMap Linkage Disequilibrium report for HOXB13 (46802125 - 46806540 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for HOXB13:    About this table    
Variant IDTypeSubtypePubMed ID
dgv988e1CNV Complex17122850

Human Gene Mutation Database (HGMD): HOXB13
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing HOXB13
DNA2.0 Custom Variant and Variant Library Synthesis for HOXB13

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604607    OMIM disorders: --

5 diseases for HOXB13:    
About MalaCards
spinal cord ependymoma    familial prostate cancer    ependymoma    prostate cancer, progression and metastasis of
prostate cancer

2 diseases from the University of Copenhagen DISEASES database for HOXB13:
Spinal cord ependymoma     Prostate cancer

Find genes that share disorders with HOXB13           About GenesLikeMe

Genetic Association Database (GAD): HOXB13
Human Genome Epidemiology (HuGE) Navigator: HOXB13 (1 document)

Export disorders for HOXB13 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HOXB13 gene, integrated from 10 sources (see all 58):
(articles sorted by number of sources associating them with HOXB13)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PubMed id 9665387)1, 2, 3 Stelnicki E.J....Largman C. (J. Invest. Dermatol. 1998)
  2. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. (PubMed id 8756292)1, 2, 3 Zeltser L.M.... Heintz N. (Development 1996)
  3. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. (PubMed id 18794098)1, 4 Goetz M.P....Ingle J.N. (Clin. Cancer Res. 2008)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Complete mutation analysis panel of the 39 human HOX genes. (PubMed id 11857506)1, 2 Kosaki K.... Matsuo N. (Teratology 2002)
  6. Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer. (PubMed id 18499701)1, 9 Rodriguez B.A....Huang T.H. (Carcinogenesis 2008)
  7. HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development. (PubMed id 12761847)1, 9 KAPmA1ves L.G....Largman C. (Dev. Dyn. 2003)
  8. A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding. (PubMed id 24390282)1 Huang Q....Wei G.H. (Nat. Genet. 2014)
  9. HOXB13 is a sensitive and specific marker of prostate cells, useful in distinguishing between carcinomas of prostatic and urothelial origin. (PubMed id 24146108)1 Varinot J....CompAcrat E. (Virchows Arch. 2013)
  10. Germline homeobox B13 (HOXB13) G84E mutation and prostate cancer risk in European descendants: a meta-analysis of 24,213 cases and 73, 631 controls. (PubMed id 23518396)1 Shang Z....Niu Y. (Eur. Urol. 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10481 HGNC: 5112 AceView: HOXB13 Ensembl:ENSG00000159184 euGenes: HUgn10481
ECgene: HOXB13 H-InvDB: HOXB13

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HOXB13 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HOXB13 gene:
Search GeneIP for patents involving HOXB13

GeneCards and IP:
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