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Aliases for HOXB13 Gene

Aliases for HOXB13 Gene

  • Homeobox B13 2 3
  • Homeobox Protein Hox-B13 3
  • Homeo Box B13 2
  • PSGD 3

External Ids for HOXB13 Gene

Previous GeneCards Identifiers for HOXB13 Gene

  • GC17M046514
  • GC17M049284
  • GC17M047145
  • GC17M047278
  • GC17M044158
  • GC17M046802
  • GC17M042171

Summaries for HOXB13 Gene

Entrez Gene Summary for HOXB13 Gene

  • This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB13 Gene

HOXB13 (Homeobox B13) is a Protein Coding gene. Diseases associated with HOXB13 include spinal cord ependymoma and prostate cancer. Among its related pathways are Regulation of Androgen receptor activity. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXB13 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXB13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB13 Gene

Genomics for HOXB13 Gene

Regulatory Elements for HOXB13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXB13 Gene

48,724,763 bp from pter
48,729,178 bp from pter
4,416 bases
Minus strand

Genomic View for HOXB13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB13 Gene

Proteins for HOXB13 Gene

  • Protein details for HOXB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Hox-B13
    Protein Accession:
    Secondary Accessions:
    • B2R878
    • Q96QM4
    • Q99810

    Protein attributes for HOXB13 Gene

    284 amino acids
    Molecular mass:
    30676 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HOXB13 Gene

neXtProt entry for HOXB13 Gene

Proteomics data for HOXB13 Gene at MOPED

Post-translational modifications for HOXB13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXB13 Gene

Domains for HOXB13 Gene

Gene Families for HOXB13 Gene

  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for HOXB13 Gene

Suggested Antigen Peptide Sequences for HOXB13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q92826
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXB13: view

Function for HOXB13 Gene

Molecular function for HOXB13 Gene

GENATLAS Biochemistry: homeo box B13
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB13: view
genes like me logo Genes that share phenotypes with HOXB13: view

Animal Models for HOXB13 Gene

MGI Knock Outs for HOXB13:

Animal Model Products

CRISPR Products

miRNA for HOXB13 Gene

miRTarBase miRNAs that target HOXB13

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXB13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXB13 Gene

Localization for HOXB13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB13 Gene

Subcellular locations from

Jensen Localization Image for HOXB13 Gene COMPARTMENTS Subcellular localization image for HOXB13 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with HOXB13: view

Pathways for HOXB13 Gene

genes like me logo Genes that share pathways with HOXB13: view

Pathways by source for HOXB13 Gene

1 BioSystems pathway for HOXB13 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Homeobox (HOX) Genes in human,mouse,rat
    • Stem Cell Transcription Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for HOXB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 17972163
GO:0002009 morphogenesis of an epithelium --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008544 epidermis development TAS 9665387
genes like me logo Genes that share ontologies with HOXB13: view

Transcripts for HOXB13 Gene

mRNA/cDNA for HOXB13 Gene

(118) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXB13 Gene

Homeobox B13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXB13

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB13 Gene

No ASD Table

Relevant External Links for HOXB13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOXB13 Gene

mRNA expression in normal human tissues for HOXB13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB13 Gene

This gene is overexpressed in Prostate (39.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXB13 Gene

SOURCE GeneReport for Unigene cluster for HOXB13 Gene Hs.66731

genes like me logo Genes that share expressions with HOXB13: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXB13 Gene

Orthologs for HOXB13 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HOXB13 35
  • 99.53 (n)
  • 100 (a)
HOXB13 36
  • 100 (a)
(Bos Taurus)
Mammalia HOXB13 35
  • 89.55 (n)
  • 93.66 (a)
HOXB13 36
  • 93 (a)
(Canis familiaris)
Mammalia HOXB13 35
  • 85.04 (n)
  • 88.34 (a)
HOXB13 36
  • 89 (a)
(Mus musculus)
Mammalia Hoxb13 35
  • 87.56 (n)
  • 93.66 (a)
Hoxb13 16
Hoxb13 36
  • 93 (a)
(Monodelphis domestica)
Mammalia HOXB13 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia HOXB13 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Hoxb13 35
  • 87.91 (n)
  • 94.37 (a)
(Gallus gallus)
Aves HOXB13 35
  • 67.06 (n)
  • 62.65 (a)
HOXB13 36
  • 58 (a)
(Anolis carolinensis)
Reptilia HOXB13 36
  • 72 (a)
(Danio rerio)
Actinopterygii hoxb13a 35
  • 64.31 (n)
  • 66.17 (a)
hoxb13a 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Abd-B 36
  • 15 (a)
Species with no ortholog for HOXB13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB13 Gene

Gene Tree for HOXB13 (if available)
Gene Tree for HOXB13 (if available)

Paralogs for HOXB13 Gene

Selected SIMAP similar genes for HOXB13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXB13: view

Variants for HOXB13 Gene

Sequence variations from dbSNP and Humsavar for HOXB13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8556 Uncertain significance 48,728,228(-) CCCAG(A/C/T)CGCCC missense, reference
rs1320283 -- 48,729,772(-) TGTCA(A/G)CTTCT upstream-variant-2KB
rs2280353 -- 48,726,489(-) TGATC(A/G)TTAGC utr-variant-3-prime
rs2411796 -- 48,727,378(-) GAGTG(A/G)CCAAG intron-variant
rs3809771 -- 48,730,557(-) GAGAC(A/G)TCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HOXB13 Gene

Variant ID Type Subtype PubMed ID
dgv988e1 CNV Complex 17122850

Relevant External Links for HOXB13 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB13 Gene

Disorders for HOXB13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for HOXB13 Gene including...

Search for HOXB13 Gene in MalaCards »


  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:22236224, ECO:0000269 PubMed:22714738, ECO:0000269 PubMed:23064873, ECO:0000269 PubMed:23292082, ECO:0000269 PubMed:25629170}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for HOXB13 Gene

Relevant External Links for HOXB13

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HOXB13: view

Publications for HOXB13 Gene

  1. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PMID: 9665387) Stelnicki E.J. … Largman C. (J. Invest. Dermatol. 1998) 2 3 4
  2. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. (PMID: 8756292) Zeltser L.M. … Heintz N. (Development 1996) 2 3 4
  3. Germline mutations in HOXB13 and prostate-cancer risk. (PMID: 22236224) Ewing C.M. … Cooney K.A. (N. Engl. J. Med. 2012) 3 4
  4. Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer. (PMID: 22714738) Breyer J.P. … Smith J.R. (Cancer Epidemiol. Biomarkers Prev. 2012) 3 4
  5. Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance. (PMID: 18794098) Goetz M.P. … Ingle J.N. (Clin. Cancer Res. 2008) 3 48

Products for HOXB13 Gene

Sources for HOXB13 Gene

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