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HOXB13 Gene(Protein Coding)

Homeobox B13

GCID:
GC17M048725
GIFtS:
61
Genes Participants
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Aliases for HOXB13 Gene

Aliases for HOXB13 Gene

  • Homeobox B13 2 3 5
  • Homeobox Protein Hox-B13 3
  • Homeo Box B13 2
  • PSGD 3

External Ids for HOXB13 Gene

Previous GeneCards Identifiers for HOXB13 Gene

  • GC17M046514
  • GC17M049284
  • GC17M047145
  • GC17M047278
  • GC17M044158
  • GC17M046802
  • GC17M042171

Summaries for HOXB13 Gene

Entrez Gene Summary for HOXB13 Gene

  • This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region. [provided by RefSeq, Jul 2008]

CIViC summary for HOXB13 Gene

GeneCards Summary for HOXB13 Gene

HOXB13 (Homeobox B13) is a Protein Coding gene. Diseases associated with HOXB13 include Prostate Cancer and Prostate Cancer Susceptibility. Among its related pathways are Regulation of Androgen receptor activity. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXA13.

UniProtKB/Swiss-Prot for HOXB13 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB13 Gene

Genomics for HOXB13 Gene

Products:

  1. Regulatory Element

Regulatory Elements for HOXB13 Gene

Enhancers for HOXB13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G048994 1.6 Ensembl ENCODE dbSUPER 10.6 -270.3 -270270 10.8 HDGF HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ZFP64 ARID4B ENSG00000238804 ENSG00000262837 PRAC2 PRAC1 HOXB13 NXPH3 UBE2Z IGF2BP1 ENSG00000251461 ATP5G1
GH17G048623 1.7 FANTOM5 ENCODE dbSUPER 9.5 +102.5 102528 6.4 HDGF PKNOX1 CREB3L1 ARNT AGO1 SIN3A FEZF1 ZNF766 CBX5 SP3 ENSG00000264701 HOXB9 PRAC2 PRAC1 HOXB13 LOC105371811 HOXB2 HOXB8 HOXB5 HOXB6
GH17G048869 1.3 Ensembl ENCODE 10.7 -142.5 -142528 5.1 FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS ATP5G1 TTLL6 CALCOCO2 UBE2Z HOXB13 PRAC1 PRAC2 SUMO2P17 LOC105371811 ENSG00000238804
GH17G048799 1 ENCODE 11.3 -71.7 -71734 3.6 ARID4B SIN3A ZNF48 YY1 SP5 MXD4 PPARG KAT8 SSRP1 MIER3 ATP5G1 TTLL6 PRAC1 PRAC2 LOC105371811 HOXB13 ENSG00000238804 ENSG00000230532 SNF8 RNU1-42P
GH17G048851 1 ENCODE dbSUPER 10.4 -122.8 -122750 1.9 BCOR IRF2 ZMYM3 ZNF664 ZNF316 GATA2 NFE2 FOS EZH2 NFE2L2 TTLL6 ATP5G1 PRAC1 PRAC2 HOXB13 LOC105371811 CALCOCO2 GC17P048882
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOXB13 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HOXB13 gene promoter:

Genomic Location for HOXB13 Gene

Chromosome:
17
Start:
48,724,763 bp from pter
End:
48,729,178 bp from pter
Size:
4,416 bases
Orientation:
Minus strand

Genomic View for HOXB13 Gene

Genes around HOXB13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXB13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXB13 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HOXB13 Gene

Proteins for HOXB13 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HOXB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92826-HXB13_HUMAN
    Recommended name:
    Homeobox protein Hox-B13
    Protein Accession:
    Q92826
    Secondary Accessions:
    • B2R878
    • Q96QM4
    • Q99810

    Protein attributes for HOXB13 Gene

    Size:
    284 amino acids
    Molecular mass:
    30676 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HOXB13 Gene

neXtProt entry for HOXB13 Gene

Protein Expression for HOXB13 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HOXB13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB13 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HOXB13

No data available for DME Specific Peptides for HOXB13 Gene

Domains & Families for HOXB13 Gene

Gene Families for HOXB13 Gene

HGNC:

Protein Domains for HOXB13 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOXB13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92826

UniProtKB/Swiss-Prot:

HXB13_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXB13: view

Function for HOXB13 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HOXB13 Gene

GENATLAS Biochemistry:
homeo box B13
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB13: view
genes like me logo Genes that share phenotypes with HOXB13: view

Animal Models for HOXB13 Gene

MGI Knock Outs for HOXB13:

Animal Model Products

CRISPR Products

Targeted motifs for HOXB13 Gene
HOMER Transcription Factor Regulatory Elements motif HOXB13
  • Consensus sequence: TTTTATKRGG Submotif: canonical Cell Type: ProstateTumor GEO ID: GSE56288

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for HOXB13 Gene

Localization for HOXB13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB13 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXB13 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
genes like me logo Genes that share ontologies with HOXB13: view

Pathways & Interactions for HOXB13 Gene

genes like me logo Genes that share pathways with HOXB13: view

Pathways by source for HOXB13 Gene

1 BioSystems pathway for HOXB13 Gene

Gene Ontology (GO) - Biological Process for HOXB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 17972163
GO:0002009 morphogenesis of an epithelium IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with HOXB13: view

No data available for SIGNOR curated interactions for HOXB13 Gene

Drugs & Compounds for HOXB13 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HOXB13 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HOXB13 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(118) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXB13 Gene

Homeobox B13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB13 Gene

No ASD Table

Relevant External Links for HOXB13 Gene

GeneLoc Exon Structure for
HOXB13
ECgene alternative splicing isoforms for
HOXB13

Expression for HOXB13 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXB13 Gene

mRNA expression in normal human tissues for HOXB13 Gene
mRNA expression by BioGPS for HOXB13 GenemRNA expression by GTEx for HOXB13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXB13 Gene

This gene is overexpressed in Prostate (x39.8).

Protein differential expression in normal tissues from HIPED for HOXB13 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXB13 Gene



Protein tissue co-expression partners for HOXB13 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOXB13 Gene:

HOXB13

SOURCE GeneReport for Unigene cluster for HOXB13 Gene:

Hs.66731

Evidence on tissue expression from TISSUES for HOXB13 Gene

  • Intestine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXB13 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • nervous
  • reproductive
Organs:
Head and neck:
  • brain
  • cerebellum
  • head
Pelvis:
  • prostate
General:
  • spinal cord
genes like me logo Genes that share expression patterns with HOXB13: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HOXB13 Gene

Orthologs for HOXB13 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HOXB13 34 35
  • 99.53 (n)
cow
(Bos Taurus)
 Mammalia HOXB13 34 35
  • 89.55 (n)
rat
(Rattus norvegicus)
 Mammalia Hoxb13 34
  • 87.91 (n)
mouse
(Mus musculus)
 Mammalia Hoxb13 34 16 35
  • 87.56 (n)
oppossum
(Monodelphis domestica)
 Mammalia HOXB13 35
  • 86 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia HOXB13 34 35
  • 85.04 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia HOXB13 35
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HOXB13 34 35
  • 67.06 (n)
lizard
(Anolis carolinensis)
 Reptilia HOXB13 35
  • 72 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii hoxb13a 34 35
  • 64.31 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Abd-B 35
  • 15 (a)
 OneToMany
Species where no ortholog for HOXB13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB13 Gene

ENSEMBL:
Gene Tree for HOXB13 (if available)
TreeFam:
Gene Tree for HOXB13 (if available)

Paralogs for HOXB13 Gene

Paralogs for HOXB13 Gene

(6) SIMAP similar genes for HOXB13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXB13: view

Variants for HOXB13 Gene

Sequence variations from dbSNP and Humsavar for HOXB13 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs138213197 Pathogenic, Prostate cancer (PC) [MIM:176807] 48,728,343(+) CGCCT(C/T)CAAAG reference, missense
rs145059285 Uncertain significance 48,727,011(+) AAAGG(A/C/T)GCAGG reference, missense
rs200997384 Uncertain significance 48,726,813(+) CTTCA(A/C)CTTGG reference, missense
rs587780160 Uncertain significance 48,728,481(-) CCCAG(A/C/G/T)GGCGC reference, missense
rs587780161 Uncertain significance 48,728,395(-) CATGC(C/T)CTGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HOXB13 Gene

Variant ID Type Subtype PubMed ID
esv2758694 CNV gain 17122850

Variation tolerance for HOXB13 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXB13 Gene

Human Gene Mutation Database (HGMD)
HOXB13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXB13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB13 Gene

Disorders for HOXB13 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HOXB13 Gene - From: GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
prostate cancer susceptibility
spinal cord ependymoma
  • ependymal neoplasm of the spinal cord
spinal cord glioma
  • glial neoplasm spinal cord
spinal cancer
  • spinal cord cancer
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

HXB13_HUMAN
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:22236224, ECO:0000269 PubMed:22714738, ECO:0000269 PubMed:23064873, ECO:0000269 PubMed:23292082, ECO:0000269 PubMed:25629170, ECO:0000269 PubMed:27424772}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for HOXB13

Genetic Association Database (GAD)
HOXB13
Human Genome Epidemiology (HuGE) Navigator
HOXB13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXB13
genes like me logo Genes that share disorders with HOXB13: view

No data available for Genatlas for HOXB13 Gene

Publications for HOXB13 Gene

  1. Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds. (PMID: 9665387) Stelnicki E.J. … Largman C. (J. Invest. Dermatol. 1998) 2 3 4 64
  2. Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity. (PMID: 8756292) Zeltser L.M. … Heintz N. (Development 1996) 2 3 4 64
  3. Imputation of the Rare HOXB13 G84E Mutation and Cancer Risk in a Large Population-Based Cohort. (PMID: 25629170) Hoffmann T.J. … Witte J.S. (PLoS Genet. 2015) 3 4 64
  4. HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). (PMID: 23064873) Xu J. … Isaacs W.B. (Hum. Genet. 2013) 3 4 64
  5. HOXB13 G84E mutation in Finland: population-based analysis of prostate, breast, and colorectal cancer risk. (PMID: 23292082) Laitinen V.H. … Schleutker J. (Cancer Epidemiol. Biomarkers Prev. 2013) 3 4 64

Products for HOXB13 Gene

Sources for HOXB13 Gene

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