Aliases for HOXB1 Gene
External Ids for HOXB1 Gene
Previous HGNC Symbols for HOXB1 Gene
Previous GeneCards Identifiers for HOXB1 Gene
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXB1 Gene
HOXB1 (Homeobox B1) is a Protein Coding gene. Diseases associated with HOXB1 include Facial Paresis, Hereditary Congenital, 3 and Congenital Hereditary Facial Paralysis-Variable Hearing Loss Syndrome. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include sequence-specific DNA binding and protein domain specific binding. An important paralog of this gene is HOXA1.
UniProtKB/Swiss-Prot for HOXB1 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.