HOXA9 Gene

Aliases
for HOXA9 gene

Previous GC identifers: GC07U990049 GC07M026844 GC07M026910 GC07M026945 GC07M026946 GC07M026975 GC07M027168 GC07M027213 GC07M027214

Summaries
for HOXA9 gene

Genomic Views
for HOXA9 gene

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOXA9 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXA9

HOXA9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027219:  view genomic region     (about GC identifiers)

Proteins
for HOXA9 gene

Explore the universe of human proteins at neXtProt for HOXA9: NX_P31269

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: HOXA9 OriGene Protein Over-expression Lysate: HOXA9 OriGene Custom Protein Services for HOXA9
	GenScript Custom Purified and Recombinant Proteins Services for HOXA9
	Novus Biologicals HOXA9 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HOXA9

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of HOXA9
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for HOXA9
	GenScript Custom Superior Antibodies Services for HOXA9
	Novus Biologicals HOXA9 Antibodies
	Abcam antibodies for HOXA9
	Uscn Antibodies for HOXA9
	ThermoFisher Antibodies for HOXA9

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for HOXA9
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HOXA9

Protein Domains /
Families
for HOXA9 gene

ProtoNet protein and cluster: P31269

Function
for HOXA9 gene

		10/685 SABiosciences Target genes for HOXA9 (see all 685):
		AADACL3 AASDH ABCA5 ABCA6 ABCG5 ACADL ACBD5 ACRC ADAM23 ADAMTSL4

miRNA Products:		miRTarBase miRNAs that target HOXA9: hsa-mir-210 (MIRT000149), hsa-mir-145 (MIRT001917), hsa-mir-126 (MIRT001918)
		OriGene 3'-UTR Clone: HOXA9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXA9
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA9 (see all 39):
		hsa-miR-124* hsa-let-7d hsa-miR-300 hsa-miR-139-5p hsa-miR-128 hsa-miR-3142 hsa-let-7g hsa-miR-548m
		SwitchGear 3'UTR luciferase reporter plasmid: HOXA9 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXA9 (see all 7) OriGene shRNA RFP: HOXA9 OriGene siRNA: HOXA9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXA9

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for HOXA9

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA9 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA9 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: HOXA9 (NM_152739)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXA9
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA9

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for HOXA9
		Search LifeMap BioReagents cell lines for HOXA9

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA9

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 2 alleles) (MGI details for Hoxa9)

Pathways & Interactions
for HOXA9 gene

	Super-pathway	contained gene-specific pathways
1	TGF-beta Receptor Signaling Pathway	TGF-beta Receptor Signaling Pathway 1.00

1 BioSystems Pathway for HOXA9

TGF-beta Receptor Signaling Pathway

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

Drugs & Compounds
for HOXA9 gene

Transcripts
for HOXA9 gene

Expression
for HOXA9 gene

HOXA9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

6 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LimbLimb BudLimb Bud Mesenchyme Cells			Mesoderm
	SomiteLumbar Mesenchymal SclerotomeLumbar Sclerotome Cells			Bone, Cartilage, Tendons & Ligaments
	KidneyMetanephric MesenchymeMetanephric Mesenchyme Cells			Kidney
	PlacentaChorioallantoic PlacentaExtraembryonic Angioblasts			Endothelium
	KidneyRenal Vesicle			Kidney
	KidneyS-shaped Body			Kidney
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 7 LifeMap Cells
	Name			Category
	Human umbilical vein endothelial cells (HUVEC) (Primary Cell)			Endothelium
	Endothelial-like cells (Derivation and purif...)
	Endothelial progenitor cells (Derivation and purif...)
	CD31, CD144 positive cells (Two-step protocol fo...)
	Podocalyxin+, CD24+, GCTM2- (Derivation and sorti...)
	Mesendoderm (Derivation and sorti...)
	Podocalyxin+, CD24+, GCTM2 (low) (Derivation and sorti...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOXA9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXA9
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXA9
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXA9

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA9

Orthologs
for HOXA9 gene

Paralogs
for HOXA9 gene

Paralogs for HOXA9 gene

HOXA13²  HOXC9²  HOXD11²  HOXC12²  ENSG00000257184²  HOXB13²  HOXD10²  HOXC11²  

HOXA11²  HOXD13²  HOXC13²  HOXB9²  HOXC10²  HOXD9²  HOXD12²  HOXA10²  

6 SIMAP similar genes for HOXA9 using alignment to 2 protein entries:     HXA9_HUMAN (see all proteins):

HOXA-9    HOXC9    HOXB9    HOXA10    HOXC10    HOXD9

HOXA9 for paralogs           About GeneDecksing

Genomic Variants
for HOXA9 gene

10/109 NCBI SNPs in HOXA9 are shown (see all 109)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1927455791,2		--	27201571(+)	GCAAGA/CCCCCA	2	--	ds5001		0	--	--	--	--
rs1847420391,2		--	27201577(+)	CCCCAA/GAATGT	2	--	ds5001		0	--	--	--	--
rs353357611,2	C,	--	27202109(+)	TCAAC-/ACAACAAT	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs1901226101,2		--	27202168(+)	GTTCAA/GTCTGA	2	--	nc-transcript-variantut31		0	--	--	--	--
rs1817376851,2		--	27202285(+)	ATTTCA/CTCCAA	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs102596201,2	C,F,A,H,	--	27202289(+)	CCTCCG/AATTAA	2	--	ut31 nc-transcript-variantese3		38		NS EA NA WA CSA	3733
rs1490012661,2		--	27202340(+)	GTATAA/GCTCCG	2	--	nc-transcript-variantut31		0	--	--	--	--
rs1459058651,2		--	27202353(+)	TTTCCC/TCACTG	2	--	ut31 nc-transcript-variant		0	--	--	--	--
rs1864363141,2		--	27202462(+)	GATAAC/TGGACA	2	--	nc-transcript-variantut31		0	--	--	--	--
rs1892770581,2		--	27202630(+)	AGCTAC/TACTCT	2	--	nc-transcript-variantut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for HOXA9 (27202054 - 27210117 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for HOXA9: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOXA9

DNA2.0 Custom Variant and Variant Library Synthesis for HOXA9

Disorders / Diseases
for HOXA9 gene

20/33 diseases for HOXA9

10/11 Novoseek disease relationships for HOXA9 gene (see all 11)    About this table

Publications
for HOXA9 gene

PubMed articles for HOXA9 gene, integrated from 9 sources (see all 198): (articles sorted by number of sources associating them with HOXA9)

Utopia: connect your pdf to the dynamic world of online information

1. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PubMed id 12649177)^{1, 2, 9} Barbouti A.... Fioretos T. (2003)
2. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. (PubMed id 8563754)^{1, 2, 9} Borrow J.... Housman D.E. (1996)
3. HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules. (PubMed id 22269951)^{1, 2} Bandyopadhyay S.... Dicorleto P.E. (2012)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
6. Endothelial cells express a novel, tumor necrosis factor-alpha- regulated variant of HOXA9. (PubMed id 9880515)^{1, 2} Patel C.V.... DiCorleto P.E. (1999)
7. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)^{1, 3} Scott M.P. (1992)
8. Nomenclature for human homeobox genes. (PubMed id 1973146)^{1, 3} McAlpine P.J. and Shows T.B. (1990)
9. The human HOX gene family. (PubMed id 2574852)^{1, 2} Acampora D.... Boncinelli E. (1989)
10. Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9. (PubMed id 18068911)^{1, 9} Trivedi C.M....Patel C.V. (2008)

External Searches for HOXA9 gene

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Products
for HOXA9 gene