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Aliases for HOXA9 Gene

Aliases for HOXA9 Gene

  • Homeobox A9 2 3
  • HOX1G 3 4 6
  • Homeobox Protein Hox-1G 3 4
  • Homeodomain Protein HOXA9 3
  • Homeobox Protein Hox-A9 3
  • Homeo Box A9 2
  • HOX1.7 3
  • ABD-B 3
  • HOX1 3

External Ids for HOXA9 Gene

Previous Symbols for HOXA9 Gene

  • HOX1G
  • HOX1

Summaries for HOXA9 Gene

Entrez Gene Summary for HOXA9 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for HOXA9 Gene

HOXA9 (Homeobox A9) is a Protein Coding gene. Diseases associated with HOXA9 include acute leukemia and myelodysplastic syndrome. Among its related pathways are Transcriptional misregulation in cancer and TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXA9 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

Gene Wiki entry for HOXA9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA9 Gene

Genomics for HOXA9 Gene

Genomic Location for HOXA9 Gene

Start:
27,162,435 bp from pter
End:
27,175,180 bp from pter
Size:
12,746 bases
Orientation:
Minus strand

Genomic View for HOXA9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA9 Gene

Regulatory Elements for HOXA9 Gene

Transcription factor binding sites by QIAGEN in the HOXA9 gene promoter:

Proteins for HOXA9 Gene

  • Protein details for HOXA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31269-HXA9_HUMAN
    Recommended name:
    Homeobox protein Hox-A9
    Protein Accession:
    P31269
    Secondary Accessions:
    • O43369
    • O43429
    • Q99820

    Protein attributes for HOXA9 Gene

    Size:
    272 amino acids
    Molecular mass:
    30172 Da
    Quaternary structure:
    • Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.
    SequenceCaution:
    • Sequence=AAC50364.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HOXA9 Gene

Proteomics data for HOXA9 Gene at MOPED

Post-translational modifications for HOXA9 Gene

  • Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXA9 Gene

Domains for HOXA9 Gene

Gene Families for HOXA9 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

UniProtKB/Swiss-Prot:

HXA9_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P31269
Family:
  • Belongs to the Abd-B homeobox family.:
    • P31269
genes like me logo Genes that share domains with HOXA9: view

Function for HOXA9 Gene

Molecular function for HOXA9 Gene

GENATLAS Biochemistry: homeo box A9(1G),with two alternatively spliced isoforms,including either exon AB or CD,homologous to mouse Hox-1.7,Drosophila abd-B,fused with NUP98 in acute myeloid leukemia with translocation t(7;11),see AML2
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

Gene Ontology (GO) - Molecular Function for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 16189514
GO:0019899 enzyme binding IPI 22269951
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXA9: view
genes like me logo Genes that share phenotypes with HOXA9: view

Animal Models for HOXA9 Gene

MGI Knock Outs for HOXA9:
Targeting motifs for HOXA9 Gene
HOMER Transcription Factor Regulatory Elements motif HOXA9
  • Consensus sequence: GGCCATAAATCA Submotif: canonical Cell Type: HSC GeoId: GSE33509

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for HOXA9 Gene

Localization for HOXA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA9 Gene COMPARTMENTS Subcellular localization image for HOXA9 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with HOXA9: view

Pathways for HOXA9 Gene

genes like me logo Genes that share pathways with HOXA9: view

Pathways by source for HOXA9 Gene

1 BioSystems pathway for HOXA9 Gene
1 KEGG pathway for HOXA9 Gene

Gene Ontology (GO) - Biological Process for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis --
GO:0007338 single fertilization --
genes like me logo Genes that share ontologies with HOXA9: view

Compounds for HOXA9 Gene

(2) Novoseek inferred chemical compound relationships for HOXA9 Gene

Compound -log(P) Hits PubMed IDs
estradiol 0 1
tyrosine 0 3
genes like me logo Genes that share compounds with HOXA9: view

Transcripts for HOXA9 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2:
SP3:

Relevant External Links for HOXA9 Gene

GeneLoc Exon Structure for
HOXA9
ECgene alternative splicing isoforms for
HOXA9

Expression for HOXA9 Gene

mRNA expression in normal human tissues for HOXA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA9 Gene

This gene is overexpressed in Kidney - Cortex (5.8) and Fallopian Tube (5.4).
genes like me logo Genes that share expressions with HOXA9: view

Orthologs for HOXA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA9 36
  • 99.14 (n)
  • 99.26 (a)
HOXA9 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXA9 36
  • 93.87 (n)
  • 97.06 (a)
HOXA9 37
  • 55 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 97 (a)
OneToMany
HOXA9 36
  • 94.24 (n)
  • 97.43 (a)
mouse
(Mus musculus)
Mammalia Hoxa9 36
  • 92.87 (n)
  • 98.15 (a)
Hoxa9 16
Hoxa9 37
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100909740 36
  • 92.62 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 81 (a)
ManyToMany
-- 37
  • 81 (a)
ManyToMany
-- 37
  • 89 (a)
ManyToMany
LOC100858870 36
  • 79.23 (n)
  • 78.08 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 95 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia hoxa9-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa9 36
  • 71.79 (n)
  • 70.77 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxa9a 37
  • 42 (a)
ManyToMany
hoxa9a 37
  • 20 (a)
ManyToMany
hoxa9b 37
  • 48 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 18 (a)
OneToMany
Species with no ortholog for HOXA9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA9 Gene

ENSEMBL:
Gene Tree for HOXA9 (if available)
TreeFam:
Gene Tree for HOXA9 (if available)

Paralogs for HOXA9 Gene

Selected SIMAP similar genes for HOXA9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXA9: view

Variants for HOXA9 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXA9 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7232n71 CNV Loss 21882294
dgv7233n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7236n71 CNV Loss 21882294

Relevant External Links for HOXA9 Gene

HapMap Linkage Disequilibrium report
HOXA9

No data available for Sequence variations from dbSNP and Humsavar for HOXA9 Gene

Disorders for HOXA9 Gene

UniProtKB/Swiss-Prot

HXA9_HUMAN
  • Note=A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98.
  • Note=A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.

(1) University of Copenhagen DISEASES for HOXA9 Gene

(11) Novoseek inferred disease relationships for HOXA9 Gene

Disease -log(P) Hits PubMed IDs
leukemogenesis 79 6
leukemia 64 33
myeloid leukemia 63.2 7
acute leukemia 58.8 6
myelodysplastic syndromes 40.8 3

Relevant External Links for HOXA9

Genetic Association Database (GAD)
HOXA9
Human Genome Epidemiology (HuGE) Navigator
HOXA9
genes like me logo Genes that share disorders with HOXA9: view

Publications for HOXA9 Gene

  1. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. (PMID: 8563754) Borrow J. … Housman D.E. (Nat. Genet. 1996) 3 4 23
  2. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PMID: 12649177) Barbouti A. … Fioretos T. (Cancer Res. 2003) 3 4 23
  3. Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). (PMID: 11830496) Fujino T. … Nakamura T. (Blood 2002) 3 23
  4. Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. (PMID: 12923056) LaRonde-LeBlanc N.A. … Wolberger C. (Genes Dev. 2003) 3 23
  5. The oncogene Nup98-HOXA9 induces gene transcription in myeloid cells. (PMID: 14561764) Ghannam G. … Yaseen N.R. (J. Biol. Chem. 2004) 3 23

Products for HOXA9 Gene

  • Addgene plasmids for HOXA9

Sources for HOXA9 Gene

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