Aliases for HOXA9 Gene
External Ids for HOXA9 Gene
Previous HGNC Symbols for HOXA9 Gene
Previous GeneCards Identifiers for HOXA9 Gene
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]
GeneCards Summary for HOXA9 Gene
HOXA9 (Homeobox A9) is a Protein Coding gene. Diseases associated with HOXA9 include acute leukemia and myelodysplastic syndrome. Among its related pathways are Transcriptional misregulation in cancer and TGF-beta Receptor Signaling Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is HOXD10.
UniProtKB/Swiss-Prot for HOXA9 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.