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Aliases & Descriptions for HOXA9
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ABD-B 2 | | HOX1 2 | | HOX1.7 2 | | HOX1G 2, 3, 5 | | Hox-1G 3 | | MGC1934 2 |
| | | Descriptions |
|---|
| homeo box A9 1, 2 | | homeobox A9 2 | | homeobox protein HOXA9 2 | | homeodomain protein HOXA9 2 |
|
| | Search outside databases for aliases for HOXA9 genePrevious GC identifers: GC07U990049 GC07M026844 GC07M026910 GC07M026945 GC07M026946 GC07M026975 |
Summaries for HOXA9(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HOXA9: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. [provided by RefSeq] UniProtKB/Swiss-Prot: HXA9_HUMAN, P31269Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axisGene Wiki entry for HOXA9 |
Genomic Location for HOXA9
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HOXA9 gene 
Entrez Gene cytogenetic band: 7p15-p14 Ensembl cytogenetic band: 7p15.2 HGNC cytogenetic band: 7p15.2HOXA9 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M027168:
(about GC identifiers)
Start:
|
27,168,582 bp from pter |
End:
|
27,175,794 bp from pter |
Size:
|
7,213 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 27,253,232-27,256,324 |
RefSeq DNA sequence:- NC_000007.12 NT_007819.16 NT_079592.2
| Proteins for HOXA9
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HXA9_HUMAN, P31269 (See
protein sequence)Recommended Name: Homeobox protein Hox-A9 Size: 272 amino acids; 30172 Da
Subcellular location: Nucleus
Secondary accessions: O43369 O43429 Q99820Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_689952.1
ENSEMBL proteins: ENSP00000379634 ENSP00000242050 ENSP00000343619 ENSP00000222443
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for HOXA9: Assays for HOXA9: | Protein
Domains/ Families for HOXA9(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P31269
ProtoNet protein and cluster: P31269 2 Blocks protein families: IPB000047 Lambda and other repressor helix-turn-helix signature IPB006711 Hox9 activation region
UniProtKB/Swiss-Prot: HXA9_HUMAN, P31269Similarity: Belongs to the Abd-B homeobox familySimilarity: Contains 1 homeobox DNA-binding domain | Gene Function for HOXA9
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_152739
Applied Biosystems Silencer® siRNAs for HOXA9
Sigma-Aldrich siRNA for HOXA9  Sigma-Aldrich shRNA for HOXA9  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_152739                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152739                                  untagged cDNA clone in CMV expression vector: NM_152739 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_152739
UniProtKB/Swiss-Prot: HXA9_HUMAN, P31269Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axisGenatlas biochemistry entry for HOXA9:homeo box A9(1G),with two alternatively spliced isoforms,including either exon AB or CD,homologous to mouse Hox-1.7,Drosophila abd-B,fused with NUP98 in acute myeloid leukemia with translocation t(7;11),see AML27 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hoxa9):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for HOXA9
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for HOXA9 
5/31 Interacting proteins for HOXA9 (P312691 ENSP000003436193) via UniProtKB, MINT, and/or STRING (see all 31
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
TAS | 8563754 | About this table
|
Drugs & Compounds for HOXA9(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HOXA9 2 Novoseek chemical compound relationships for HOXA9 gene
About this table
|
Transcripts for HOXA9(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_152739
Sigma-Aldrich siRNA for HOXA9  Sigma-Aldrich shRNA for HOXA9  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_152739 REFSEQ mRNAs for HOXA9 gene: NM_152739.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_152739               OriGene GFP tagged cDNA clone in CMV expression vector: NM_152739                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_152739                                  untagged cDNA clone in CMV expression vector: NM_152739  Additional cDNA sequence: BC006537.2 BC010023.2 BT006990.1 DQ655931.2 U41813.1 U82759.1 4 DOTS entries: DT.410695 DT.100742593 DT.91718437 DT.95262960 24/182 AceView cDNA sequences (see all 182
):NM_002142 AW612608 NM_152739 BE328694 AW770908 BX104119 NM_018951 AA195633 NM_153715 BM796352 AA599729 BC010023 AW452853 AA613299 AA535695 CA442923 AI187278 BQ422016 BC006537 AL080006 BE292889 BF434948 BU624206 AA577580
highest scoring ESTs for HOXA9:U41813 U82759 AL080006 BC006537 BC010023 BE292889 BG258601 BG284372 BG717723 BQ422016 Unigene Cluster for HOXA9: Homeobox A9 Hs.659350 [show with all ESTs]Unigene Representative Sequence: NM_152739
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for HOXA9
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | |
| SP1: | |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for HOXA9
4 Ensembl transcripts including schematic representations: ENST00000396345
ENST00000242050
ENST00000343483
ENST00000354032
|
Expression for HOXA9
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HOXA9 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HOXA9
1 / 2 / 3 6 probe-sets matching HOXA9 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TACCTCACCA
SOURCE GeneReport for Unigene cluster: Hs.659350
Expression variation in blood from EXPOLDB for HOXA9 |
Orthologs for HOXA9
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HOXA9 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for HOXA9
ENSEMBL Gene Tree for HOXA9 | Paralogs for HOXA9(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HOXA9 gene
- HOXC92 HOXB92 HOXD92
|
SNPs/Variants for HOXA9(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HOXA9 (up to first 250kb)
|
Disorders & Mutations for HOXA9
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 142956
UniProtKB/Swiss-Prot: HXA9_HUMAN, P31269
A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98 A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI210/11 Novoseek disease relationships for HOXA9 gene (see all 11
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leukemogenesis |
79.36 |
6 |
15755900 (2), 17379095 (1), 10698505 (1), 11830496 (1) (see all 5) |
| myeloid leukemia |
64.60 |
7 |
10602420 (2), 10996203 (1), 14713950 (1), 11687616 (1) (see all 6) |
| leukemia |
64.55 |
45 |
19056693 (4), 8563753 (3), 15755900 (3), 12358913 (2) (see all 23) |
| acute leukemia |
58.78 |
7 |
16102826 (2), 16518848 (1), 18337761 (1), 15160920 (1) (see all 5) |
| myelodysplastic syndromes |
42.99 |
3 |
15982348 (2), 17178874 (1) |
| myeloid leukemia chronic |
35.13 |
4 |
11830496 (1), 12649177 (1), 10602420 (1), 16630659 (1) |
| lymphoblastic leukemia acute |
33.74 |
3 |
11314021 (1), 16102826 (1), 18337761 (1) |
| chromosomal aberrations |
19.19 |
2 |
11314021 (1), 10565304 (1) |
| hematologic malignancies |
4.75 |
1 |
12461755 (1) |
| cancer |
0.00 |
1 |
15709170 (1) |
About this table
1 PharmGKB disease relationship for HOXA9 geneAbout this table
|
Medical News for HOXA9(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HOXA9 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/164 PubMed articles for HOXA9 gene (see all 164
):- A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PubMed id 12649177)1, 3, 4 Barbouti A.... Fioretos T. (2003)
- The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. (PubMed id 8563754)1, 3, 4 Borrow J.... Housman D.E. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Endothelial cells express a novel, tumor necrosis factor-alpha-regulated variant of HOXA9. (PubMed id 9880515)3, 4 Patel C.V....DiCorleto P.E. (1999)
- Vertebrate homeobox gene nomenclature. (PubMed id 1358459)2, 3 Scott M.P. (1992)
- Nomenclature for human homeobox genes. (PubMed id 1973146)2, 3 McAlpine P.J. and Shows T.B. (1990)
- The human HOX gene family. (PubMed id 2574852)3, 4 Acampora D.... Boncinelli E. (1989)
- Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9. (PubMed id 18068911)1, 3 Trivedi C.M....Patel C.V. (2008)
- HoxA9 induces insulin-like growth factor-1 receptor expression in B-lineage acute lymphoblastic leukemia. (PubMed id 18337761)1, 3 Whelan J.T....Bertrand F.E. (2008)
|
Search for HOXA9
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HOXA9
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HOXA9
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HOXA9(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HOXA9(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HOXA9:

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Incremental update: 13 Oct 2009
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