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Aliases & Descriptions for HOXA7
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ANTP 2 | | HOX1 2 | | HOX1.1 2 | | HOX1A 2, 3, 5 | | Hox-1A 3 | | OTTHUMP00000024835 2 |
| | | Descriptions |
|---|
| Hox 1.1 3 | | homeo box A7 1, 2 | | homeobox A7 2 | | homeobox protein HOX-1A 2 |
|
| | Search outside databases for aliases for HOXA7 genePrevious GC identifers: GC07M026836 GC07M026936 GC07M026967 |
Summaries for HOXA7(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for HOXA7: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq] UniProtKB/Swiss-Prot: HXA7_HUMAN, P31268Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axisGene Wiki entry for HOXA7 |
Genomic Location for HOXA7
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the HOXA7 gene 
Entrez Gene cytogenetic band: 7p15-p14 Ensembl cytogenetic band: 7p15.2 HGNC cytogenetic band: 7p15.2HOXA7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M027159:
(about GC identifiers)
Start:
|
27,159,860 bp from pter |
End:
|
27,164,080 bp from pter |
Size:
|
4,221 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 27,244,510-27,247,471 |
RefSeq DNA sequence:- NC_000007.12 NT_007819.16 NT_079592.2
| Proteins for HOXA7
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: HXA7_HUMAN, P31268 (See
protein sequence)Recommended Name: Homeobox protein Hox-A7 Size: 230 amino acids; 25385 Da
Subcellular location: Nucleus
Secondary accessions: O43368 O43486 O95655 Q9NSC8 Q9UDM1REFSEQ proteins: NP_008827.2
ENSEMBL proteins: ENSP00000379636 ENSP00000242159
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for HOXA7: Assays for HOXA7: | Protein
Domains/ Families for HOXA7(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P31268
ProtoNet protein and cluster: P31268 1 Blocks protein family: IPB001827 Homeobox protein
UniProtKB/Swiss-Prot: HXA7_HUMAN, P31268Similarity: Belongs to the Antp homeobox familySimilarity: Contains 1 homeobox DNA-binding domain | Gene Function for HOXA7
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006896
Applied Biosystems Silencer® siRNAs for HOXA7
Sigma-Aldrich siRNA for HOXA7  Sigma-Aldrich shRNA for HOXA7  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006896                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006896                                  untagged cDNA clone in CMV expression vector: NM_006896 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006896
UniProtKB/Swiss-Prot: HXA7_HUMAN, P31268Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axisGenatlas biochemistry entry for HOXA7:homeo box A7(1A),homologous to mouse Hox-1.1,Drosophila Antp,Ubx,abd-A,expressed in erythroleukemic cell line4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Hoxa7):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for HOXA7
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for HOXA7 
5/6 Interacting proteins for HOXA7 (ENSP000002421593) via UniProtKB, MINT, and/or STRING (see all 6
)About this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IDA | 11435435 | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0009952 | anterior/posterior pattern formation |
IEA | -- | | GO:0045617 | negative regulation of keratinocyte differentiation |
IDA | 11435435 | About this table
|
Drugs & Compounds for HOXA7(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for HOXA7
|
Transcripts for HOXA7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006896
Sigma-Aldrich siRNA for HOXA7  Sigma-Aldrich shRNA for HOXA7  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006896 REFSEQ mRNAs for HOXA7 gene: NM_006896.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006896               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006896                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006896                                  untagged cDNA clone in CMV expression vector: NM_006896  Additional cDNA sequence: AF026397.1 BC061916.1 2 DOTS entries: DT.75101351 DT.40253843 24/34 AceView cDNA sequences (see all 34
):AW450368 AW470294 AI887912 AK096334 AI650267 BE645526 AW450250 AI492051 AX747263 AW205417 AK091933 BF970710 AA557521 AI660992 BF510786 AA570160 AI762011 AI830321 AK092154 BE146237 F37656 BE146039 AW292631 H28870
highest scoring ESTs for HOXA7:AI985100 AW793597 AW182613 AX747263 BP263590 AA187553 AF026397 AI287617 BC061916 BG110135 Unigene Cluster for HOXA7: Homeobox A7 Hs.660918 [show with all ESTs]Unigene Representative Sequence: NM_006896
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000396347
ENST00000242159
|
Expression for HOXA7
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| HOXA7 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for HOXA7
1 / 2 / 3 8 probe-sets matching HOXA7 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTATGTTGTC
SOURCE GeneReport for Unigene cluster: Hs.660918
|
Orthologs for HOXA7
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for HOXA7 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for HOXA7
ENSEMBL Gene Tree for HOXA7 | Paralogs for HOXA7(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for HOXA7 gene
- HOXC52 HOXA52 HOXB72 HOXB52
|
SNPs/Variants for HOXA7(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for HOXA7 (up to first 250kb)
|
Disorders & Mutations for HOXA7
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 142950
2 Novoseek disease relationships for HOXA7 gene
About this table
|
Medical News for HOXA7(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for HOXA7 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/55 PubMed articles for HOXA7 gene (see all 55
):- Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. (PubMed id 11435435)1, 3, 4 La Celle P.T. and Polakowska R.R. (2001)
- Sequence analysis and tissue specific expression of human HOXA7. (PubMed id 10911612)1, 3, 4 Kim M.H.... Park H.W. (2000)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Sequence characterisation and expression of homeobox HOX A7 in the multi-potential erythroleukaemic cell line TF-1. (PubMed id 9804983)3, 4 McIlhatton M.A.... Lappin T.R. (1998)
- Vertebrate homeobox gene nomenclature. (PubMed id 1358459)2, 3 Scott M.P. (1992)
- Nomenclature for human homeobox genes. (PubMed id 1973146)2, 3 McAlpine P.J. and Shows T.B. (1990)
- Organization of human class I homeobox genes. (PubMed id 2576652)3, 4 Boncinelli E.... Simeone A. (1989)
- HOXA7 in epithelial ovarian cancer: interrelationships between differentiation and clinical features. (PubMed id 17959889)3 Ota T....Auersperg N. (2007)
- cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. (PubMed id 16597639)3 Huntriss J....Picton H.M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
|
Search for HOXA7
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing HOXA7
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing HOXA7
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HOXA7(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for HOXA7(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for HOXA7:

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Incremental update: 13 Oct 2009
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