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Aliases for HOXA7 Gene

Aliases for HOXA7 Gene

  • Homeobox A7 2 3
  • HOX1A 3 4 6
  • Homeobox Protein Hox 1.1 3 4
  • Homeo Box A7 2 3
  • Homeobox Protein HOX-1A 3
  • Homeobox Protein Hox-A7 3
  • Homeobox Protein Hox-1A 4
  • HOX1.1 3
  • HOX1 3
  • ANTP 3

External Ids for HOXA7 Gene

Previous HGNC Symbols for HOXA7 Gene

  • HOX1A
  • HOX1

Previous GeneCards Identifiers for HOXA7 Gene

  • GC07M026836
  • GC07M026936
  • GC07M026967
  • GC07M027159
  • GC07M027193

Summaries for HOXA7 Gene

Entrez Gene Summary for HOXA7 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA7 Gene

HOXA7 (Homeobox A7) is a Protein Coding gene. Diseases associated with HOXA7 include acute leukemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is HOXD8.

UniProtKB/Swiss-Prot for HOXA7 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA7 Gene

Genomics for HOXA7 Gene

Regulatory Elements for HOXA7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXA7 Gene

Start:
27,153,716 bp from pter
End:
27,157,936 bp from pter
Size:
4,221 bases
Orientation:
Minus strand

Genomic View for HOXA7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA7 Gene

Proteins for HOXA7 Gene

  • Protein details for HOXA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31268-HXA7_HUMAN
    Recommended name:
    Homeobox protein Hox-A7
    Protein Accession:
    P31268
    Secondary Accessions:
    • A4D191
    • O43368
    • O43486
    • O95655
    • Q9NSC8
    • Q9UDM1

    Protein attributes for HOXA7 Gene

    Size:
    230 amino acids
    Molecular mass:
    25355 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA7 Gene

Proteomics data for HOXA7 Gene at MOPED

Post-translational modifications for HOXA7 Gene

  • Ubiquitination at Lys147
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXA7 Gene

Domains for HOXA7 Gene

Gene Families for HOXA7 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31268

UniProtKB/Swiss-Prot:

HXA7_HUMAN :
  • P31268
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXA7: view

Function for HOXA7 Gene

Molecular function for HOXA7 Gene

GENATLAS Biochemistry: homeo box A7(1A),homologous to mouse Hox-1.1,Drosophila Antp,Ubx,abd-A,expressed in erythroleukemic cell line
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 11435435
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 11435435
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0008134 transcription factor binding IPI 18973687
genes like me logo Genes that share ontologies with HOXA7: view
genes like me logo Genes that share phenotypes with HOXA7: view

Animal Models for HOXA7 Gene

MGI Knock Outs for HOXA7:

Animal Model Products

CRISPR Products

miRNA for HOXA7 Gene

miRTarBase miRNAs that target HOXA7

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXA7 Gene

Localization for HOXA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA7 Gene COMPARTMENTS Subcellular localization image for HOXA7 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 11435435
genes like me logo Genes that share ontologies with HOXA7: view

Pathways for HOXA7 Gene

SuperPathways for HOXA7 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11435435
GO:0001525 angiogenesis IEP 17972163
GO:0001953 negative regulation of cell-matrix adhesion IDA 14704364
GO:0002686 negative regulation of leukocyte migration IDA 14704364
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOXA7: view

No data available for Pathways by source for HOXA7 Gene

Transcripts for HOXA7 Gene

mRNA/cDNA for HOXA7 Gene

Unigene Clusters for HOXA7 Gene

Homeobox A7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXA7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for HOXA7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA7 Gene

No ASD Table

Relevant External Links for HOXA7 Gene

GeneLoc Exon Structure for
HOXA7
ECgene alternative splicing isoforms for
HOXA7

Expression for HOXA7 Gene

mRNA expression in normal human tissues for HOXA7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA7 Gene

This gene is overexpressed in Adrenal Gland (4.6) and Fallopian Tube (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOXA7 Gene

SOURCE GeneReport for Unigene cluster for HOXA7 Gene Hs.610216

genes like me logo Genes that share expressions with HOXA7: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXA7 Gene

Orthologs for HOXA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA7 35
  • 99.57 (n)
  • 99.13 (a)
HOXA7 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXA7 35
  • 93.23 (n)
  • 95.43 (a)
HOXA7 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXA7 35
  • 96.34 (n)
  • 98.95 (a)
HOXA7 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxa7 35
  • 92.17 (n)
  • 95 (a)
Hoxa7 16
Hoxa7 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXA7 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA7 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911622 35
  • 92.17 (n)
  • 93 (a)
chicken
(Gallus gallus)
Aves HOXA7 35
  • 81.65 (n)
  • 86.36 (a)
HOXA7 36
  • 80 (a)
OneToMany
HOXA7 36
  • 80 (a)
OneToMany
HOXA7 36
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HOXA7 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hox36 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa7 35
  • 76.5 (n)
  • 79.23 (a)
Str.10310 35
fruit fly
(Drosophila melanogaster)
Insecta Antp 36
  • 25 (a)
OneToMany
Antp 37
  • 85 (a)
Species with no ortholog for HOXA7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HOXA7 Gene

ENSEMBL:
Gene Tree for HOXA7 (if available)
TreeFam:
Gene Tree for HOXA7 (if available)

Paralogs for HOXA7 Gene

Selected SIMAP similar genes for HOXA7 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HOXA7 Gene

genes like me logo Genes that share paralogs with HOXA7: view

Variants for HOXA7 Gene

Sequence variations from dbSNP and Humsavar for HOXA7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs985652 -- 27,158,464(+) CAAGA(A/C)GGCTA upstream-variant-2KB
rs2301720 -- 27,156,450(+) TTGGG(A/C)GCAAA synonymous-codon, reference
rs2301721 - 27,156,494(+) AGAAG(C/T)CCCCG missense, reference
rs4722665 -- 27,157,700(+) AAACA(A/G)ATAGG upstream-variant-2KB
rs4722666 -- 27,157,982(+) GATTA(C/G)ACACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HOXA7 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7232n71 CNV Loss 21882294
dgv7233n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
nsv5674 CNV Loss 18451855
nsv887876 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7236n71 CNV Loss 21882294
nsv526526 CNV Loss 19592680

Relevant External Links for HOXA7 Gene

HapMap Linkage Disequilibrium report
HOXA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA7 Gene

Disorders for HOXA7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HOXA7 Gene including...

Search for HOXA7 Gene in MalaCards »

(2) Novoseek inferred disease relationships for HOXA7 Gene

Disease -log(P) Hits PubMed IDs
leukemia 26 1
acute leukemia 24.8 1

Relevant External Links for HOXA7

Genetic Association Database (GAD)
HOXA7
Human Genome Epidemiology (HuGE) Navigator
HOXA7
genes like me logo Genes that share disorders with HOXA7: view

No data available for UniProtKB/Swiss-Prot for HOXA7 Gene

Publications for HOXA7 Gene

  1. Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. (PMID: 11435435) La Celle P.T. … Polakowska R.R. (J. Biol. Chem. 2001) 3 4 23
  2. Sequence analysis and tissue specific expression of human HOXA7. (PMID: 10911612) Kim M.H. … Park H.W. (Mol. Biotechnol. 2000) 3 4 23
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 48
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for HOXA7 Gene

Sources for HOXA7 Gene

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