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HOXA7 Gene

protein-coding   GIFtS: 56

GC07M027159
homeobox A7
(Previous name: homeo box A7 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: HOX1A, HOX1)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ANTP 2
HOX1 2
HOX1.1 2
HOX1A 2, 3, 5
Hox-1A 3
OTTHUMP00000024835 2
Descriptions
Hox 1.1 3
homeo box A7 1, 2
homeobox A7 2
homeobox protein HOX-1A 2
External Ids
HGNC: 51081
Entrez Gene: 32042
UniProtKB: P312683
Ensembl: ENSG000001225927
Search outside databases for aliases for HOXA7 gene

Previous GC identifers: GC07M026836 GC07M026936 GC07M026967

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for HOXA7:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are
found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins
is spatially and temporally regulated during embryonic development. This gene is part of the A
cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene
expression, morphogenesis, and differentiation. For example, the encoded protein represses the
transcription of differentiation-specific genes during keratinocyte proliferation, but this
repression is then overcome by differentiation signals. This gene is highly similar to the
antennapedia (Antp) gene of Drosophila. [provided by RefSeq]

UniProtKB/Swiss-Prot: HXA7_HUMAN, P31268
Function: Sequence-specific transcription factor which is part of a developmental regulatory system
that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the HOXA7 gene  

Entrez Gene cytogenetic band: 7p15-p14   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027159:     (about GC identifiers)

Start:
27,159,860 bp from pter
End:
27,164,080 bp from pter
Size:
4,221 bases
Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,244,510-27,247,471     
RefSeq DNA sequence:
NC_000007.12  NT_007819.16  NT_079592.2  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: HXA7_HUMAN, P31268 (See protein sequence)
Recommended Name: Homeobox protein Hox-A7  
Size: 230 amino acids; 25385 Da
Subcellular location: Nucleus
Secondary accessions: O43368 O43486 O95655 Q9NSC8 Q9UDM1

REFSEQ proteins: NP_008827.2  

ENSEMBL proteins: 
ENSP00000379636 ENSP00000242159 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Antennapedia homeodomain , HOXA7)
Human Recombinant Proteins from Abnova (HOXA7)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
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Antibodies for HOXA7: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for HOXA7
Browse R&D Systems for Antibodies
Antibodies from Abcam (Antennapedia homeodomain , HOXA7), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (HOXA7)
Novus Biologicals Antibodies for HOXA7

Assays for HOXA7: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR017995 Homeobox_antennapedia
 IPR001827 Homeobox_Antennapedia_CS
 IPR001356 Homeobox
 IPR017970 Homeobox_CS
 IPR012287 Homeodomain-rel


   GeneDecks  HOXA7 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P31268

ProtoNet protein and cluster: P31268

1 Blocks protein family: IPB001827 Homeobox protein

UniProtKB/Swiss-Prot: HXA7_HUMAN, P31268
Similarity: Belongs to the Antp homeobox family
Similarity: Contains 1 homeobox DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (HOXA7)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (HOXA7)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006896

              Applied Biosystems Silencer® siRNAs for HOXA7

              Sigma-Aldrich siRNA for HOXA7  
                     Sigma-Aldrich shRNA for HOXA7  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for HOXA7
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006896
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006896
                                 untagged cDNA clone in CMV expression vector: NM_006896 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_006896

UniProtKB/Swiss-Prot: HXA7_HUMAN, P31268
Function: Sequence-specific transcription factor which is part of a developmental regulatory system
that provides cells with specific positional identities on the anterior-posterior axis

Genatlas biochemistry entry for HOXA7:
homeo box A7(1A),homologous to mouse Hox-1.1,Drosophila Antp,Ubx,abd-A,expressed in erythroleukemic
cell line

4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxa7):

hematopoietic systemimmune systemnormalskeleton

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity TAS9804983
GO:0005515 protein binding IEA--
GO:0016564 transcription repressor activity IEA--
GO:0043565 sequence-specific DNA binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  HOXA7 


5/6 Interacting proteins for HOXA7 (ENSP000002421593) via UniProtKB, MINT, and/or STRING (see all 6 )
InteractantInteraction Details
GeneCardExternal ID(s)
FOSENSP000003062453STRING (score=.925)
BIDENSP000003188223STRING (score=.899)
ETS1ENSP000003245783STRING (score=.899)
ETS2ENSP000003533443STRING (score=.899)
SP1ENSP000003293573STRING (score=.899)
About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA11435435
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0007275 multicellular organismal development IEA--
GO:0009952 anterior/posterior pattern formation IEA--
GO:0045617 negative regulation of keratinocyte differentiation IDA11435435
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for HOXA7

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (HOXA7)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (HOXA7)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006896

              Sigma-Aldrich siRNA for HOXA7  
                     Sigma-Aldrich shRNA for HOXA7  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_006896  

REFSEQ mRNAs for HOXA7 gene: 

NM_006896.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_006896  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006896
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006896
                                 untagged cDNA clone in CMV expression vector: NM_006896 

Additional cDNA sequence: 

AF026397.1 BC061916.1 

2 DOTS entries:

DT.75101351  DT.40253843 

24/34 AceView cDNA sequences (see all 34 ):

AW450368 AW470294 AI887912 AK096334 AI650267 BE645526 AW450250 AI492051 
AX747263 AW205417 AK091933 BF970710 AA557521 AI660992 BF510786 AA570160 
AI762011 AI830321 AK092154 BE146237 F37656 BE146039 AW292631 H28870 

highest scoring ESTs for HOXA7:

AI985100 AW793597 AW182613 AX747263 BP263590 AA187553 AF026397 AI287617 BC061916 BG110135 

Unigene Cluster for HOXA7:

Homeobox A7
Hs.660918  [show with all ESTs]
Unigene Representative Sequence: NM_006896


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:
ENST00000396347  ENST00000242159  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

HOXA7 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for HOXA7

1 / 2 / 3

8 probe-sets matching HOXA7 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
84021_at2, 3 U95-E 1 1.00 1.00 0.90 1.66 AI492051 0.40 0.50 0.45 1

40343_at*2, 3 U95-A 1 0.94 1.00 0.46 0.39 AJ005814 0.40 0.50 0.45 1

235753_at2, 3 U133-B 1 1.00 1.00 -- -- AI492051 0.40 0.50 0.45 1

206847_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF026397 0.60 0.75 0.68 1

206848_at*2, 3 U133-A 1 1.00 1.00 -- -- NM_006896 0.40 0.67 0.55 1

235753_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

206847_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

206848_at*2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  HOXA7 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GTATGTTGTC

SOURCE GeneReport for Unigene cluster: Hs.660918
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for HOXA7 gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
HOXA71   -- homeobox A7 93.71(n)
95.61(a)
482371  XM_859585.1  XP_864678.1 
chimpanzee
(Pan troglodytes)
HOXA71   -- homeobox A7 99.57(n)
99.13(a)
745634  XM_001162845.1  XP_001162845.1 
cow
(Bos taurus)
HOXA71   -- homeobox A7 92.47(n)
94.47(a)
615851  XM_867772.1  XP_872865.1 
mouse
(Mus musculus)
Hoxa71, 5 6 (26.30 cM)5
homeo box A71, 5 90.6(n)1
92.07(a)1
154041  NM_010455.21  NP_034585.11 
 AA6385155  AK0335005  (see all 12)
chicken
(Gallus gallus)
HOXA71   -- homeobox A7 79.15(n)
80.82(a)
395290  NM_204595.1  NP_989926.1 
About this table        Species with no ortholog for HOXA7

ENSEMBL Gene Tree for HOXA7
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for HOXA7 gene
HOXC52  HOXA52  HOXB72  HOXB52  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/29 NCBI SNPs in HOXA7 are shown (see all 29 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 72)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 7 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs9856521,2
A,C,F,H27164608(+) CAAGAC/AGGCTA 1 -- ng316Minor allele frequency- A:0.31MN EU EA WA 760
rs23017211,2
A,C,F,H27162638(+) AGAAGT/CCCCCG 1 T/A mis1 ese310Minor allele frequency- C:0.24EA EU WA 2502
rs47226651,2
A,C,F,H27163844(+) AAACAA/GATAGG 1 -- ng31 tfbs35Minor allele frequency- G:0.15EU EA WA 584
rs10575121,2
C,F,H27160128(-) TTTTTT/ATTTAT 1 -- ut316Minor allele frequency- A:0.00MN EU EA WA 760
rs47226661,2
A,C27164126(+) GATTAC/GACACC 1 -- ng310--------
rs174720841,2
F,H27160839(+) GCGACC/ACAGTC 1 -- ut31 ese33Minor allele frequency- A:0.01EA WA 290
rs175009251,2
F,H27160125(+) ATGATA/TAAAAA 1 -- ut314Minor allele frequency- T:0.02EU EA WA 396
rs174720981,2
H27163613(+) CTTTCC/TACAAC 1 -- ng314Minor allele frequency- T:0.00EU EA WA 404
rs174721051,2
H27164196(+) GTTCCT/ATGTGT 1 -- ng314Minor allele frequency- A:0.00EU EA WA 392
rs175009181,2
H27160003(+) ATTGGA/GCCTCC 1 -- ut311Minor allele frequency- G:0.00EU 114
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HapMap Linkage Disequilibrium images for HOXA7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 142950

2 Novoseek disease relationships for HOXA7 gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia 27.72 1 11681416 (1)
acute leukemia 26.56 1 15160920 (1)
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/55 PubMed articles for HOXA7 gene (see all 55 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3204 HGNC: 5108 AceView: HOXA7.1 Ensembl:ENSG00000122592 euGenes: HUgn3204
ECgene: HOXA7 H-InvDB: HOXA7
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for HOXA7 Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for HOXA7:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Millipore Preclinical / Clinical Development Services
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 Predesigned and custom siRNAs for HOXA7 Antibodies for HOXA7
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 Lentivirus-delivered shRNAs for HOXA7 Browse small molecules at Sigma-Aldrich
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 Antibodies for HOXA7

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