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Aliases for HOXA7 Gene

Aliases for HOXA7 Gene

  • Homeobox A7 2 3 5
  • Homeobox Protein Hox 1.1 3 4
  • Homeo Box A7 2 3
  • HOX1A 3 4
  • Homeobox Protein HOX-1A 3
  • Homeobox Protein Hox-A7 3
  • Homeobox Protein Hox-1A 4
  • HOX1.1 3
  • HOX1 3
  • ANTP 3

External Ids for HOXA7 Gene

Previous HGNC Symbols for HOXA7 Gene

  • HOX1A
  • HOX1

Previous GeneCards Identifiers for HOXA7 Gene

  • GC07M026836
  • GC07M026936
  • GC07M026967
  • GC07M027159
  • GC07M027193

Summaries for HOXA7 Gene

Entrez Gene Summary for HOXA7 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA7 Gene

HOXA7 (Homeobox A7) is a Protein Coding gene. Diseases associated with HOXA7 include Oculoauricular Syndrome and Clivus Chordoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is HOXB7.

UniProtKB/Swiss-Prot for HOXA7 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXA7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA7 Gene

Genomics for HOXA7 Gene

Regulatory Elements for HOXA7 Gene

Enhancers for HOXA7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G027661 1.1 ENCODE 10.9 -505.0 -504967 3.3 HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 EIF4HP1 HIBADH HOXA7 LOC105375211
GH07G027095 3.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 2.7 +19.7 19741 86.3 MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 HOTAIRM1 HOXA10-AS HOXA2 HOXA-AS2 HOXA9 HOXA11-AS HOXA10 HOXA11 EIF4HP1 SKAP2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOXA7 on UCSC Golden Path with GeneCards custom track

Promoters for HOXA7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209844 1436 1001 HDGF PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 FOS REST SMARCB1 GLIS1

Genomic Location for HOXA7 Gene

Chromosome:
7
Start:
27,153,716 bp from pter
End:
27,157,936 bp from pter
Size:
4,221 bases
Orientation:
Minus strand

Genomic View for HOXA7 Gene

Genes around HOXA7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA7 Gene

Proteins for HOXA7 Gene

  • Protein details for HOXA7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31268-HXA7_HUMAN
    Recommended name:
    Homeobox protein Hox-A7
    Protein Accession:
    P31268
    Secondary Accessions:
    • A4D191
    • O43368
    • O43486
    • O95655
    • Q9NSC8
    • Q9UDM1

    Protein attributes for HOXA7 Gene

    Size:
    230 amino acids
    Molecular mass:
    25355 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA7 Gene

Post-translational modifications for HOXA7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXA7 Gene

Domains & Families for HOXA7 Gene

Gene Families for HOXA7 Gene

Suggested Antigen Peptide Sequences for HOXA7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31268

UniProtKB/Swiss-Prot:

HXA7_HUMAN :
  • Belongs to the Antp homeobox family.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXA7: view

Function for HOXA7 Gene

Molecular function for HOXA7 Gene

GENATLAS Biochemistry:
homeo box A7(1A),homologous to mouse Hox-1.1,Drosophila Antp,Ubx,abd-A,expressed in erythroleukemic cell line
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 11435435
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 11435435
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0008134 transcription factor binding IPI 18973687
genes like me logo Genes that share ontologies with HOXA7: view
genes like me logo Genes that share phenotypes with HOXA7: view

Animal Models for HOXA7 Gene

MGI Knock Outs for HOXA7:

Animal Model Products

CRISPR Products

miRNA for HOXA7 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXA7

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXA7 Gene

Localization for HOXA7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXA7 gene
Compartment Confidence
nucleus 5
plasma membrane 2

Gene Ontology (GO) - Cellular Components for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 11435435
GO:0005654 nucleoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with HOXA7: view

Pathways & Interactions for HOXA7 Gene

SuperPathways for HOXA7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXA7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11435435
GO:0001525 angiogenesis IEP 17972163
GO:0001953 negative regulation of cell-matrix adhesion IDA 14704364
GO:0002686 negative regulation of leukocyte migration IDA 14704364
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOXA7: view

No data available for Pathways by source and SIGNOR curated interactions for HOXA7 Gene

Transcripts for HOXA7 Gene

mRNA/cDNA for HOXA7 Gene

Unigene Clusters for HOXA7 Gene

Homeobox A7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXA7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA7 Gene

No ASD Table

Relevant External Links for HOXA7 Gene

GeneLoc Exon Structure for
HOXA7
ECgene alternative splicing isoforms for
HOXA7

Expression for HOXA7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXA7 Gene

mRNA differential expression in normal tissues according to GTEx for HOXA7 Gene

This gene is overexpressed in Adrenal Gland (x4.6) and Fallopian Tube (x4.1).

Protein differential expression in normal tissues from HIPED for HOXA7 Gene

This gene is overexpressed in Urine (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA7 Gene



Protein tissue co-expression partners for HOXA7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HOXA7 Gene:

HOXA7

SOURCE GeneReport for Unigene cluster for HOXA7 Gene:

Hs.610216

Evidence on tissue expression from TISSUES for HOXA7 Gene

  • Nervous system(2.7)
  • Muscle(2.4)
  • Kidney(2.3)
  • Stomach(2)
genes like me logo Genes that share expression patterns with HOXA7: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA7 Gene

Orthologs for HOXA7 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA7 34 35
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia HOXA7 34 35
  • 96.34 (n)
cow
(Bos Taurus)
Mammalia HOXA7 34 35
  • 93.23 (n)
mouse
(Mus musculus)
Mammalia Hoxa7 34 16 35
  • 92.17 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911622 34
  • 92.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA7 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXA7 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858856 34
  • 81.65 (n)
HOXA7 35 35 35
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HOXA7 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa7 34
  • 76.5 (n)
Str.10310 34
African clawed frog
(Xenopus laevis)
Amphibia hox36 34
fruit fly
(Drosophila melanogaster)
Insecta Antp 36 35
  • 85 (a)
Species where no ortholog for HOXA7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HOXA7 Gene

ENSEMBL:
Gene Tree for HOXA7 (if available)
TreeFam:
Gene Tree for HOXA7 (if available)

Paralogs for HOXA7 Gene

(14) SIMAP similar genes for HOXA7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXA7: view

Variants for HOXA7 Gene

Sequence variations from dbSNP and Humsavar for HOXA7 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000292300 -- 27,158,142(+) AAAGG(C/T)GGAGG upstream-variant-2KB
rs1000360737 -- 27,156,224(+) CAGCG(A/C)GCCCT downstream-variant-500B, reference, missense
rs1000568757 -- 27,156,976(+) CCAAG(C/T)TTGGG upstream-variant-2KB
rs1000580191 -- 27,156,738(+) GCTCC(A/G)CAGGG upstream-variant-2KB
rs1002304049 -- 27,157,693(+) ACACC(A/G)AAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HOXA7 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
dgv11244n54 CNV loss 21841781
nsv526526 CNV loss 19592680
nsv5674 CNV deletion 18451855
nsv606465 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Variation tolerance for HOXA7 Gene

Residual Variation Intolerance Score: 66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXA7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXA7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA7 Gene

Disorders for HOXA7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HOXA7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oculoauricular syndrome
  • ocacs
clivus chordoma
  • chordoma of clivus
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search HOXA7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOXA7

Genetic Association Database (GAD)
HOXA7
Human Genome Epidemiology (HuGE) Navigator
HOXA7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXA7
genes like me logo Genes that share disorders with HOXA7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA7 Gene

Publications for HOXA7 Gene

  1. Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. (PMID: 11435435) La Celle P.T. … Polakowska R.R. (J. Biol. Chem. 2001) 3 4 22 64
  2. Sequence analysis and tissue specific expression of human HOXA7. (PMID: 10911612) Kim M.H. … Park H.W. (Mol. Biotechnol. 2000) 3 4 22 64
  3. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  4. HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. (PMID: 17972163) Chung N. … Rha H.K. (Mol. Biol. Rep. 2009) 3 22 64
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64

Products for HOXA7 Gene

Sources for HOXA7 Gene

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