Aliases for HOXA7 Gene
Aliases for HOXA7 Gene
External Ids for HOXA7 Gene
- HGNC: 5108
- Entrez Gene: 3204
- Ensembl: ENSG00000122592
- OMIM: 142950
- UniProtKB: P31268
Previous HGNC Symbols for HOXA7 Gene
- HOX1A
- HOX1
Previous GeneCards Identifiers for HOXA7 Gene
- GC07M026836
- GC07M026936
- GC07M026967
- GC07M027159
- GC07M027193
Summaries for HOXA7 Gene
-
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA7 Gene
HOXA7 (Homeobox A7) is a Protein Coding gene. Diseases associated with HOXA7 include Oculoauricular Syndrome and Clivus Chordoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is HOXB7.
UniProtKB/Swiss-Prot for HOXA7 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA7 Gene
Genomics for HOXA7 Gene
Regulatory Elements for HOXA7 Gene
Enhancers for HOXA7 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G027661 | 1.1 | ENCODE | 10.9 | -505.0 | -504967 | 3.3 | HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 YY1 | EIF4HP1 HIBADH HOXA7 LOC105375211 |
| GH07G027095 | 3.3 | VISTA FANTOM5 Ensembl ENCODE dbSUPER | 2.7 | +19.7 | 19741 | 86.3 | MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 | HOTAIRM1 HOXA10-AS HOXA2 HOXA-AS2 HOXA9 HOXA11-AS HOXA10 HOXA11 EIF4HP1 SKAP2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXA7 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXA7 gene promoter:
Regulatory Element Products
Genomic Location for HOXA7 Gene
- Chromosome:
- 7
- Start:
- 27,153,716 bp from pter
- End:
- 27,157,936 bp from pter
- Size:
- 4,221 bases
- Orientation:
- Minus strand
Genomic View for HOXA7 Gene
Genes around HOXA7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
HOXA7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXA7 Gene
Proteins for HOXA7 Gene
-
Protein details for HOXA7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31268-HXA7_HUMAN
- Recommended name:
- Homeobox protein Hox-A7
- Protein Accession:
- P31268
- A4D191
- O43368
- O43486
- O95655
- Q9NSC8
- Q9UDM1
Protein attributes for HOXA7 Gene
- Size:
- 230 amino acids
- Molecular mass:
- 25355 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXA7 Gene
Post-translational modifications for HOXA7 Gene
Other Protein References for HOXA7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HOXA7
-
Custom Antibody ServicesOriGene Antibodies for HOXA7
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-
Abcam antibodies for HOXA7
- Invitrogen Antibodies for HOXA7
- antibodies-online Antibodies for HOXA7: See all 50
- GeneTex HOXA7 antibody for HOXA7
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXA7
Protein Products
-
OriGene Purified Proteins for HOXA7
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXA7
- Origene Custom Protein Services for HOXA7
- antibodies-online Proteins for HOXA7: See all 15
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXA7
Assay Products
- antibodies-online Kits for HOXA7: See all 1
No data available for DME Specific Peptides for HOXA7 Gene
Domains & Families for HOXA7 Gene
Gene Families for HOXA7 Gene
Protein Domains for HOXA7 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXA7 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31268- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXA7 Gene
Molecular function for HOXA7 Gene
- GENATLAS Biochemistry:
- homeo box A7(1A),homologous to mouse Hox-1.1,Drosophila Antp,Ubx,abd-A,expressed in erythroleukemic cell line
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 11435435 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IDA | 11435435 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0008134 | transcription factor binding | IPI | 18973687 |
Phenotypes for HOXA7 Gene
- MGI mutant phenotypes for HOXA7:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXA7:
Animal Models for HOXA7 Gene
- MGI Knock Outs for HOXA7:
-
- Hoxa7 tm1Mrc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA7 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for HOXA7
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA7
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miRNA for HOXA7 Gene
- miRTarBase miRNAs that target HOXA7
miRNA Products
- Search ViGene Biosciences for HOXA7
Inhibitory RNA Products
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-
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-
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Cell Line Products
-
Horizon Cell Lines for HOXA7
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXA7 Gene
Localization for HOXA7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXA7 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IC | 11435435 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0031965 | nuclear membrane | IDA | -- |
Pathways & Interactions for HOXA7 Gene
No Data Available
Interacting Proteins for HOXA7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 11435435 |
| GO:0001525 | angiogenesis | IEP | 17972163 |
| GO:0001953 | negative regulation of cell-matrix adhesion | IDA | 14704364 |
| GO:0002686 | negative regulation of leukocyte migration | IDA | 14704364 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXA7 Gene
Transcripts for HOXA7 Gene
mRNA/cDNA for HOXA7 Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (34) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HOXA7 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HOXA7
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA7
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miRNA Products
- Search ViGene Biosciences for HOXA7
Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA7 gene
Clone Products
-
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Flow Cytometry Products
Expression for HOXA7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Endothelium (Cardiovascular System)
- Kidney (Urinary System)
- Motor Neurons (Nervous System)
- Neurons
- Spinal Cord (Nervous System)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for HOXA7 Gene
This gene is overexpressed in Adrenal Gland (x4.6) and Fallopian Tube (x4.1).
This gene is overexpressed in Urine (68.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA7 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HOXA7 Gene:
HOXA7SOURCE GeneReport for Unigene cluster for HOXA7 Gene:
Hs.610216Evidence on tissue expression from TISSUES for HOXA7 Gene
- Nervous system(2.7)
- Muscle(2.4)
- Kidney(2.3)
- Stomach(2)
Primer Products
-
OriGene qPCR primer pairs for HOXA7
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA7 Gene
Orthologs for HOXA7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXA7 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXA7 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXA7 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxa7 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100911622 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXA7 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HOXA7 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100858856 34 |
|
||
| HOXA7 35 35 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | HOXA7 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxa7 34 |
|
||
| Str.10310 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | hox36 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Antp 36 35 |
|
- Species where no ortholog for HOXA7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HOXA7 Gene
Paralogs for HOXA7 Gene
(14) SIMAP similar genes for HOXA7 Gene using alignment to 2 proteins:
Variants for HOXA7 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000292300 | -- | 27,158,142(+) | AAAGG(C/T)GGAGG | upstream-variant-2KB | |
| rs1000360737 | -- | 27,156,224(+) | CAGCG(A/C)GCCCT | downstream-variant-500B, reference, missense | |
| rs1000568757 | -- | 27,156,976(+) | CCAAG(C/T)TTGGG | upstream-variant-2KB | |
| rs1000580191 | -- | 27,156,738(+) | GCTCC(A/G)CAGGG | upstream-variant-2KB | |
| rs1002304049 | -- | 27,157,693(+) | ACACC(A/G)AAAAC | upstream-variant-2KB |
Residual Variation Intolerance Score:
66.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.76;
47.04% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXA7 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXA7
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA7 Gene
Disorders for HOXA7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| oculoauricular syndrome |
|
|
| clivus chordoma |
|
|
| leukemia, acute myeloid |
|
|
Search HOXA7 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXA7
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA7 Gene
Publications for HOXA7 Gene
- Human homeobox HOXA7 regulates keratinocyte transglutaminase type 1 and inhibits differentiation. (PMID: 11435435) La Celle P.T. … Polakowska R.R. (J. Biol. Chem. 2001) 3 4 22 64
- Sequence analysis and tissue specific expression of human HOXA7. (PMID: 10911612) Kim M.H. … Park H.W. (Mol. Biotechnol. 2000) 3 4 22 64
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
- HOX gene analysis of endothelial cell differentiation in human bone marrow-derived mesenchymal stem cells. (PMID: 17972163) Chung N. … Rha H.K. (Mol. Biol. Rep. 2009) 3 22 64
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
Products for HOXA7 Gene
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Sources for HOXA7 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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