Aliases for HOXA6 Gene
Aliases for HOXA6 Gene
External Ids for HOXA6 Gene
- HGNC: 5107
- Entrez Gene: 3203
- Ensembl: ENSG00000106006
- OMIM: 142951
- UniProtKB: P31267
Previous HGNC Symbols for HOXA6 Gene
- HOX1B
- HOX1
Previous GeneCards Identifiers for HOXA6 Gene
- GC07M026827
- GC07M026927
- GC07M026958
- GC07M027151
- GC07M027065
- GC07M027185
Summaries for HOXA6 Gene
-
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA6 Gene
HOXA6 (Homeobox A6) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXB6.
UniProtKB/Swiss-Prot for HOXA6 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA6 Gene
Genomics for HOXA6 Gene
Regulatory Elements for HOXA6 Gene
Enhancers for HOXA6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXA6 on UCSC Golden Path with GeneCards custom track
Promoters for HOXA6 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|---|---|---|
| ENSR00000325319 | -297 | 601 | PKNOX1 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ZHX2 REST SMARCB1 ZNF623 |
| ENSR00000209842 | 603 | 401 | PKNOX1 SUZ12 ZIC2 HIC1 GLIS2 ZNF366 POLR2A SCRT2 EZH2 ZNF263 |
| ENSR00000325320 | -1297 | 201 | ZSCAN4 KLF17 FEZF1 GLI4 GLIS2 ZNF366 KLF7 ZNF488 ZEB2 ZNF398 |
- Transcription factor binding sites by QIAGEN in the HOXA6 gene promoter:
Regulatory Element Products
Genomic Location for HOXA6 Gene
- Chromosome:
- 7
- Start:
- 27,145,396 bp from pter
- End:
- 27,150,603 bp from pter
- Size:
- 5,208 bases
- Orientation:
- Minus strand
Genomic View for HOXA6 Gene
Genes around HOXA6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
HOXA6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXA6 Gene
Proteins for HOXA6 Gene
-
Protein details for HOXA6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31267-HXA6_HUMAN
- Recommended name:
- Homeobox protein Hox-A6
- Protein Accession:
- P31267
- A4D192
- Q2M3G3
- Q9UPM0
Protein attributes for HOXA6 Gene
- Size:
- 233 amino acids
- Molecular mass:
- 26339 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXA6 Gene
Post-translational modifications for HOXA6 Gene
Other Protein References for HOXA6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOXA6
- Novus Biologicals Antibodies for HOXA6
- Invitrogen Antibodies for HOXA6
- antibodies-online Antibodies for HOXA6: See all 62
- GeneTex HOXA6 antibody for HOXA6
Protein Products
-
OriGene Purified Proteins for HOXA6
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXA6
- Origene Custom Protein Services for HOXA6
- antibodies-online Proteins for HOXA6: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXA6
Assay Products
No data available for DME Specific Peptides for HOXA6 Gene
Domains & Families for HOXA6 Gene
Gene Families for HOXA6 Gene
Protein Domains for HOXA6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXA6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31267- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXA6 Gene
Molecular function for HOXA6 Gene
- GENATLAS Biochemistry:
- homeo box A6(1B),homologous to mouse Hox-1.2,Drosophila Antp,Ubx,abd-A
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXA6 Gene
- MGI mutant phenotypes for HOXA6:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOXA6:
Animal Models for HOXA6 Gene
- MGI Knock Outs for HOXA6:
-
- Hoxa6 tm1Mrc
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA6 gene
- Search ViGene Biosciences for HOXA6
CRISPR Products
-
OriGene CRISPR knockouts for HOXA6
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA6
- GenScript: Design CRISPR guide RNA sequences for HOXA6
miRNA for HOXA6 Gene
- miRTarBase miRNAs that target HOXA6
miRNA Products
- Search ViGene Biosciences for HOXA6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXA6
- Browse OriGene Inhibitory RNA Products For HOXA6
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA6 gene
Clone Products
-
OriGene ORF clones in human for HOXA6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HOXA6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HOXA6
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXA6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA6 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXA6 Gene
Localization for HOXA6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXA6 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for HOXA6 Gene
No Data Available
Interacting Proteins for HOXA6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009952 | anterior/posterior pattern specification | IEA | -- |
| GO:0048704 | embryonic skeletal system morphogenesis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOXA6 Gene
Transcripts for HOXA6 Gene
mRNA/cDNA for HOXA6 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (7) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXA6
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA6
- GenScript: Design CRISPR guide RNA sequences for HOXA6
miRNA Products
- Search ViGene Biosciences for HOXA6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXA6
- Browse OriGene Inhibitory RNA Products For HOXA6
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA6 gene
Clone Products
-
OriGene ORF clones in human for HOXA6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HOXA6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HOXA6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for HOXA6 Gene
This gene is overexpressed in Fallopian Tube (x7.1) and Colon - Transverse (x5.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA6 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXA6 Gene:
HOXA6SOURCE GeneReport for Unigene cluster for HOXA6 Gene:
Hs.679517Primer Products
-
OriGene qPCR primer pairs for HOXA6
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA6 Gene
Orthologs for HOXA6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXA6 35 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | HOXA6 35 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | HOXA6 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hoxa6 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxa6 16 35 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXA6 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HOXA6 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXA6 35 35 35 |
|
OneToMany | |
| LOC100857163 34 |
|
||||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxa6 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Antp 35 36 |
|
OneToMany |
- Species where no ortholog for HOXA6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HOXA6 Gene
Paralogs for HOXA6 Gene
(12) SIMAP similar genes for HOXA6 Gene using alignment to 1 proteins:
Variants for HOXA6 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000241812 | -- | 27,147,143(+) | AGCCC(C/G)ATTGG | intron-variant, upstream-variant-2KB | |
| rs1000312377 | -- | 27,145,740(+) | TCATG(C/T)GGCGG | intron-variant, upstream-variant-2KB, reference, missense | |
| rs1001081480 | -- | 27,145,492(+) | GTTTT(G/T)TTTTG | intron-variant, downstream-variant-500B, upstream-variant-2KB | |
| rs1001745979 | -- | 27,148,014(+) | CGCAC(A/G)GCTAG | intron-variant, upstream-variant-2KB | |
| rs1001779499 | -- | 27,147,829(+) | CTGGT(C/T)TGTTT | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.34;
7.47% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXA6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXA6
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA6 Gene
Disorders for HOXA6 Gene
Relevant External Links for HOXA6
No disorders were found for HOXA6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXA6 Gene
Publications for HOXA6 Gene
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
Products for HOXA6 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Custom Antibody ServicesOriGene Antibodies for HOXA6
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HOXA6
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXA6
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- OriGene qPCR primer pairs for HOXA6
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- GenScript: Design CRISPR guide RNA sequences for HOXA6
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for HOXA6
- Novus Biologicals proteins and lysates for HOXA6
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for HOXA6: See all 62
- Search antibodies-online for kits
- antibodies-online Proteins for HOXA6: See all 7
- Search antibodies-online for peptides
- GeneTex HOXA6 antibody for HOXA6
- Search GeneTex for Proteins for HOXA6
- ViGene Biosciences adenoviral particle packaged cDNA for HOXA6 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HOXA6 gene
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- Search ViGene Biosciences for HOXA6
- Horizon Cell Lines for HOXA6
- Cyagen custom Knockout/knockin (KOKI) mouse models for HOXA6
- VectorBuilder custom plasmid, inducible vectors for HOXA6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXA6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXA6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
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- (128) Genetics Home Reference
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- (133) NCBI Bookshelf
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer