Aliases for HOXA5 Gene
Aliases for HOXA5 Gene
External Ids for HOXA5 Gene
- HGNC: 5106
- Entrez Gene: 3202
- Ensembl: ENSG00000106004
- OMIM: 142952
- UniProtKB: P20719
Previous HGNC Symbols for HOXA5 Gene
- HOX1C
- HOX1
Previous GeneCards Identifiers for HOXA5 Gene
- GC07M026823
- GC07M026923
- GC07M026954
- GC07M027147
- GC07M027061
- GC07M027180
Summaries for HOXA5 Gene
-
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA5 Gene
HOXA5 (Homeobox A5) is a Protein Coding gene. Diseases associated with HOXA5 include Mediastinal Malignant Lymphoma and Mediastinal Gray Zone Lymphoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is HOXB5.
UniProtKB/Swiss-Prot for HOXA5 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5-CYYNATTA[TG]Y-3.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA5 Gene
Genomics for HOXA5 Gene
Regulatory Elements for HOXA5 Gene
Enhancers for HOXA5 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXA5 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXA5 gene promoter:
Regulatory Element Products
Genomic Location for HOXA5 Gene
- Chromosome:
- 7
- Start:
- 27,141,052 bp from pter
- End:
- 27,143,668 bp from pter
- Size:
- 2,617 bases
- Orientation:
- Minus strand
Genomic View for HOXA5 Gene
Genes around HOXA5 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
HOXA5 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXA5 Gene
Proteins for HOXA5 Gene
-
Protein details for HOXA5 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P20719-HXA5_HUMAN
- Recommended name:
- Homeobox protein Hox-A5
- Protein Accession:
- P20719
- A4D179
- O43367
- Q96CY6
Protein attributes for HOXA5 Gene
- Size:
- 270 amino acids
- Molecular mass:
- 29345 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXA5 Gene
Post-translational modifications for HOXA5 Gene
Other Protein References for HOXA5 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXA5
- Invitrogen Antibodies for HOXA5
- antibodies-online Antibodies for HOXA5: See all 114
- GeneTex HOXA5 antibody for HOXA5
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXA5
Protein Products
-
OriGene Purified Proteins for HOXA5
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXA5
- Origene Custom Protein Services for HOXA5
- antibodies-online Proteins for HOXA5: See all 12
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXA5
Assay Products
No data available for DME Specific Peptides for HOXA5 Gene
Domains & Families for HOXA5 Gene
Gene Families for HOXA5 Gene
Protein Domains for HOXA5 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXA5 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P20719- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXA5 Gene
Molecular function for HOXA5 Gene
- GENATLAS Biochemistry:
- homeo box A5(1C),homologous to mouse Hox-1.3,Drosophila Scr,expressed during early myelopoiesis,involved in the regulation of hematopoietic lineage determination and maturation,inhibiting erythropoiesis and promoting myelopoiesis
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5-CYYNATTA[TG]Y-3.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 10879542 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IDA | 10879542 |
| GO:0003677 | DNA binding | IDA | 8657138 |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IDA | 10879542 |
| GO:0005515 | protein binding | IPI | 15545268 |
Phenotypes for HOXA5 Gene
- MGI mutant phenotypes for HOXA5:
-
inferred from 5 alleles
- mortality/aging
- cellular phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for HOXA5:
Animal Models for HOXA5 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA5 gene
- Search ViGene Biosciences for HOXA5
CRISPR Products
-
OriGene CRISPR knockouts for HOXA5
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA5
- GenScript: Design CRISPR guide RNA sequences for HOXA5
miRNA for HOXA5 Gene
- miRTarBase miRNAs that target HOXA5
-
- hsa-mir-130a-3p (MIRT000958)
- hsa-mir-19a-3p (MIRT001794)
- hsa-mir-196a-5p (MIRT006906)
- hsa-mir-374b-5p (MIRT016043)
- hsa-mir-484 (MIRT016627)
- hsa-mir-340-5p (MIRT019581)
- hsa-mir-130b-3p (MIRT020201)
- hsa-mir-183-5p (MIRT025008)
- hsa-mir-19b-3p (MIRT031182)
- hsa-mir-92a-3p (MIRT049277)
- hsa-mir-5003-5p (MIRT258223)
- hsa-mir-200c-3p (MIRT320350)
- hsa-mir-5585-3p (MIRT513867)
- hsa-mir-302b-5p (MIRT513868)
- hsa-mir-302d-5p (MIRT513869)
- hsa-mir-4457 (MIRT513870)
- hsa-mir-6830-5p (MIRT513871)
- hsa-mir-6831-5p (MIRT513872)
- hsa-mir-548c-3p (MIRT513873)
- hsa-mir-3927-3p (MIRT513874)
- hsa-mir-196b-5p (MIRT513875)
- hsa-mir-6790-5p (MIRT547903)
- hsa-mir-4658 (MIRT547904)
- hsa-mir-4758-5p (MIRT547905)
- hsa-mir-1238-5p (MIRT547906)
- hsa-mir-1909-5p (MIRT547907)
- hsa-mir-8485 (MIRT547908)
- hsa-mir-4295 (MIRT547909)
- hsa-mir-301a-3p (MIRT547910)
- hsa-mir-454-3p (MIRT547911)
- hsa-mir-301b-3p (MIRT547912)
- hsa-mir-3666 (MIRT547913)
- hsa-mir-1271-5p (MIRT547914)
- hsa-mir-96-5p (MIRT547915)
Transcription Factor Targets for HOXA5 Gene
miRNA Products
- Search ViGene Biosciences for HOXA5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXA5
- Browse OriGene Inhibitory RNA Products For HOXA5
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA5 gene
Clone Products
-
OriGene ORF clones in human for HOXA5
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Cell Line Products
-
Horizon Cell Lines for HOXA5
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXA5 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA5 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA5 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HOXA5 Gene
Localization for HOXA5 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXA5 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 15545268 |
Pathways & Interactions for HOXA5 Gene
No Data Available
Interacting Proteins for HOXA5 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | IEA | -- |
| GO:0002009 | morphogenesis of an epithelium | IEA | -- |
| GO:0003016 | respiratory system process | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source for HOXA5 Gene
Transcripts for HOXA5 Gene
mRNA/cDNA for HOXA5 Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (57) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXA5
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA5
- GenScript: Design CRISPR guide RNA sequences for HOXA5
miRNA Products
- Search ViGene Biosciences for HOXA5
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXA5
- Browse OriGene Inhibitory RNA Products For HOXA5
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA5 gene
Clone Products
-
OriGene ORF clones in human for HOXA5
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXA5
Flow Cytometry Products
Expression for HOXA5 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Somite (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Tendon amp Ligament
- Sclerotome Cells Cervical Mesenchymal Sclerotome
- Motor Neurons (Nervous System)
- Neurons
- Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for HOXA5 Gene
This gene is overexpressed in Fallopian Tube (x6.8) and Adrenal Gland (x6.1).
This gene is overexpressed in Cervix (50.7), Platelet (11.3), and Fetal heart (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXA5 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HOXA5 Gene:
HOXA5SOURCE GeneReport for Unigene cluster for HOXA5 Gene:
Hs.655218Evidence on tissue expression from TISSUES for HOXA5 Gene
- Lung(2.4)
- Nervous system(2.2)
Primer Products
-
OriGene qPCR primer pairs for HOXA5
-
OriGene qPCR primer pairs and template standards for HOXA5
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA5 Gene
Orthologs for HOXA5 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXA5 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXA5 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXA5 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100909641 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxa5 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXA5 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXA5 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXA5 35 35 35 |
|
OneToMany | |
| LOC100858834 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | HOXA5 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxa5 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxa5a 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dfd 36 |
|
|
|
| Scr 36 |
|
|
|||
| ftz 35 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXA5 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXA5 Gene
Paralogs for HOXA5 Gene
(16) SIMAP similar genes for HOXA5 Gene using alignment to 2 proteins:
Variants for HOXA5 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1001081480 | -- | 27,145,492(+) | GTTTT(G/T)TTTTG | intron-variant, downstream-variant-500B, upstream-variant-2KB | |
| rs1001169296 | -- | 27,141,784(+) | TACTG(A/C)CACTA | intron-variant, utr-variant-3-prime | |
| rs1001169495 | -- | 27,141,541(+) | CTCTT(C/T)TCTTT | intron-variant, utr-variant-3-prime | |
| rs1001305429 | -- | 27,141,799(+) | GGATC(C/T)GCTAA | intron-variant, utr-variant-3-prime | |
| rs1004517423 | -- | 27,143,827(+) | ACTAA(C/T)AGGGG | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.82;
17.19% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXA5 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA5 Gene
Disorders for HOXA5 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mediastinal malignant lymphoma |
|
|
| mediastinal gray zone lymphoma |
|
|
| embryonal carcinoma |
|
Search HOXA5 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXA5
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA5 Gene
Publications for HOXA5 Gene
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 46 64
- Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. (PMID: 17957028) Chen Y. … Gorski D.H. (Blood 2008) 3 22 64
- HOXA5 regulates hMLH1 expression in breast cancer cells. (PMID: 16756717) Duriseti S. … Raman V. (Neoplasia 2006) 3 22 64
- Expression pattern of a homeotic gene, HOXA5, in normal breast and in breast tumors. (PMID: 17167183) Henderson G.S. … Raman V. (Cell. Oncol. 2006) 3 22 64
Products for HOXA5 Gene
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- Novus Biologicals Antibodies for HOXA5
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- antibodies-online Antibodies for HOXA5: See all 114
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- antibodies-online Proteins for HOXA5: See all 12
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- GeneTex HOXA5 antibody for HOXA5
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- ViGene Biosciences adenoviral particle packaged cDNA for HOXA5 gene
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- VectorBuilder custom plasmid, inducible vectors for HOXA5
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- Mammalian expression: PiggyBac
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- Yeast expression
Sources for HOXA5 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer