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Aliases for HOXA5 Gene

Aliases for HOXA5 Gene

  • Homeobox A5 2 3 5
  • Homeobox Protein Hox-1C 3 4
  • Homeo Box A5 2 3
  • HOX1C 3 4
  • Homeobox Protein Hox-A5 3
  • Homeobox Protein HOXA5 3
  • Homeo Box 1C 3
  • HOX1.3 3
  • HOX1 3

External Ids for HOXA5 Gene

Previous HGNC Symbols for HOXA5 Gene

  • HOX1C
  • HOX1

Previous GeneCards Identifiers for HOXA5 Gene

  • GC07M026823
  • GC07M026923
  • GC07M026954
  • GC07M027147
  • GC07M027061
  • GC07M027180

Summaries for HOXA5 Gene

Entrez Gene Summary for HOXA5 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA5 Gene

HOXA5 (Homeobox A5) is a Protein Coding gene. Diseases associated with HOXA5 include Mediastinal Malignant Lymphoma and Mediastinal Gray Zone Lymphoma. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is HOXB5.

UniProtKB/Swiss-Prot for HOXA5 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5-CYYNATTA[TG]Y-3.

Gene Wiki entry for HOXA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA5 Gene

Genomics for HOXA5 Gene

Regulatory Elements for HOXA5 Gene

Enhancers for HOXA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F026855 0.9 ENCODE 26.8 +286.1 286121 4.8 HDAC1 PKNOX1 FEZF1 ZBTB40 GLIS2 GATA2 ZNF366 EGR2 ZNF362 ZEB2 HOTAIRM1 HOXA5 HOXA-AS2 HOXA3 HOXA-AS3 HOXA4 HOXA6 HOXA1 HOXA2 SKAP2
GH07F026853 0.6 ENCODE 18.4 +289.7 289692 0.2 CTCF ZNF654 CHD1 SMC3 RAD21 SP7 HOXA5 HOXA3 HOXA6 HOXA-AS3 HOXA4 HOTAIRM1 HOXA1 GC07P026846 RPL7AP38
GH07F026862 1.1 ENCODE 11.8 +279.6 279554 3.1 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 HOTAIRM1 HMGB3P20 TPM3P4 PSMC1P2 RPL23P7 HOXA-AS3 HOXA4 HOXA3 HOXA6 HOXA5
GH07F026860 1.3 Ensembl ENCODE 11.8 +282.7 282668 1.2 ELF3 CTCF ZNF362 PKNOX1 ZNF654 RNF2 ZNF384 RAD21 JUND SMC3 HOXA-AS3 HOXA4 HOXA5 HOXA6 HOXA3 HOTAIRM1 HOXA1 HOXA2 HOXA-AS2 SKAP2
GH07F027095 2.8 VISTA FANTOM5 Ensembl ENCODE 11.5 +5.5 5473 86.3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 HOTAIRM1 HOXA-AS2 HOXA10-AS HOXA2 HOXA9 TPM3P4 HMGB3P20 PSMC1P2 RPL23P7 HOXA11-AS
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HOXA5 on UCSC Golden Path with GeneCards custom track

Promoters for HOXA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000623613 968 2601 PKNOX1 MLX ARID4B SIN3A FEZF1 GLIS2 ELK1 ZNF207 FOS KLF7

Genomic Location for HOXA5 Gene

Chromosome:
7
Start:
27,141,052 bp from pter
End:
27,143,668 bp from pter
Size:
2,617 bases
Orientation:
Minus strand

Genomic View for HOXA5 Gene

Genes around HOXA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA5 Gene

Proteins for HOXA5 Gene

  • Protein details for HOXA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20719-HXA5_HUMAN
    Recommended name:
    Homeobox protein Hox-A5
    Protein Accession:
    P20719
    Secondary Accessions:
    • A4D179
    • O43367
    • Q96CY6

    Protein attributes for HOXA5 Gene

    Size:
    270 amino acids
    Molecular mass:
    29345 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA5 Gene

Post-translational modifications for HOXA5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXA5 Gene

Domains & Families for HOXA5 Gene

Gene Families for HOXA5 Gene

Suggested Antigen Peptide Sequences for HOXA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20719

UniProtKB/Swiss-Prot:

HXA5_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXA5: view

Function for HOXA5 Gene

Molecular function for HOXA5 Gene

GENATLAS Biochemistry:
homeo box A5(1C),homologous to mouse Hox-1.3,Drosophila Scr,expressed during early myelopoiesis,involved in the regulation of hematopoietic lineage determination and maturation,inhibiting erythropoiesis and promoting myelopoiesis
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5-CYYNATTA[TG]Y-3.

Gene Ontology (GO) - Molecular Function for HOXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10879542
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10879542
GO:0003677 DNA binding IDA 8657138
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,IDA 10879542
GO:0005515 protein binding IPI 15545268
genes like me logo Genes that share ontologies with HOXA5: view
genes like me logo Genes that share phenotypes with HOXA5: view

Animal Models for HOXA5 Gene

MGI Knock Outs for HOXA5:

Animal Model Products

Transcription Factor Targets for HOXA5 Gene

Selected GeneGlobe predicted Target genes for HOXA5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXA5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HOXA5 Gene

Localization for HOXA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA5 Gene COMPARTMENTS Subcellular localization image for HOXA5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15545268
genes like me logo Genes that share ontologies with HOXA5: view

Pathways & Interactions for HOXA5 Gene

SuperPathways for HOXA5 Gene

No Data Available

SIGNOR curated interactions for HOXA5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HOXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0002009 morphogenesis of an epithelium IEA --
GO:0003016 respiratory system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOXA5: view

No data available for Pathways by source for HOXA5 Gene

Drugs & Compounds for HOXA5 Gene

(1) Drugs for HOXA5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for HOXA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with HOXA5: view

Transcripts for HOXA5 Gene

mRNA/cDNA for HOXA5 Gene

Unigene Clusters for HOXA5 Gene

Homeobox A5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXA5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA5 Gene

No ASD Table

Relevant External Links for HOXA5 Gene

GeneLoc Exon Structure for
HOXA5
ECgene alternative splicing isoforms for
HOXA5

Expression for HOXA5 Gene

mRNA expression in normal human tissues for HOXA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA5 Gene

This gene is overexpressed in Fallopian Tube (x6.8) and Adrenal Gland (x6.1).

Protein differential expression in normal tissues from HIPED for HOXA5 Gene

This gene is overexpressed in Cervix (50.7), Platelet (11.3), and Fetal heart (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOXA5 Gene



Protein tissue co-expression partners for HOXA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HOXA5 Gene:

HOXA5

SOURCE GeneReport for Unigene cluster for HOXA5 Gene:

Hs.655218
genes like me logo Genes that share expression patterns with HOXA5: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HOXA5 Gene

Orthologs for HOXA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA5 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia HOXA5 34 35
  • 97.41 (n)
dog
(Canis familiaris)
Mammalia HOXA5 34 35
  • 97.16 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909641 34
  • 94.94 (n)
mouse
(Mus musculus)
Mammalia Hoxa5 34 16 35
  • 94.57 (n)
oppossum
(Monodelphis domestica)
Mammalia HOXA5 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA5 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXA5 35 35 35
  • 85 (a)
OneToMany
LOC100858834 34
  • 84.51 (n)
lizard
(Anolis carolinensis)
Reptilia HOXA5 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa5 34
  • 79.73 (n)
zebrafish
(Danio rerio)
Actinopterygii hoxa5a 34 35
  • 68.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dfd 36
  • 76 (a)
Scr 36
  • 74 (a)
ftz 35
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToMany
Species where no ortholog for HOXA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA5 Gene

ENSEMBL:
Gene Tree for HOXA5 (if available)
TreeFam:
Gene Tree for HOXA5 (if available)

Paralogs for HOXA5 Gene

(16) SIMAP similar genes for HOXA5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXA5: view

Variants for HOXA5 Gene

Sequence variations from dbSNP and Humsavar for HOXA5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10155970 -- 27,142,592(+) GCAGG(A/C)TCTCG intron-variant
rs1047218 -- 27,143,383(-) GCTGC(A/C)AGCGC intron-variant, reference, synonymous-codon
rs1047290 -- 27,141,797(-) AGCGG(A/T)TCCCG intron-variant, utr-variant-3-prime
rs1047294 -- 27,141,543(-) aaaaa(A/G)aaaaa intron-variant, utr-variant-3-prime
rs10531328 -- 27,140,763(+) TTTCT(-/CCT)TTTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HOXA5 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
dgv11244n54 CNV loss 21841781
nsv526526 CNV loss 19592680
nsv5674 CNV deletion 18451855
nsv606465 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Variation tolerance for HOXA5 Gene

Residual Variation Intolerance Score: 21.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.19% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXA5 Gene

Human Gene Mutation Database (HGMD)
HOXA5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA5 Gene

Disorders for HOXA5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for HOXA5 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mediastinal malignant lymphoma
  • lymphoma of mediastinum
mediastinal gray zone lymphoma
  • mediastinal b-cell lymphoma, unclassifiable, with features intermediate between diffuse large b-cell lymphoma and classical hodgkin lymphoma
embryonal carcinoma
  • primary extragonadal embryonal carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search HOXA5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOXA5

Genetic Association Database (GAD)
HOXA5
Human Genome Epidemiology (HuGE) Navigator
HOXA5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXA5
genes like me logo Genes that share disorders with HOXA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA5 Gene

Publications for HOXA5 Gene

  1. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
  2. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 46 64
  3. Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. (PMID: 17957028) Chen Y. … Gorski D.H. (Blood 2008) 3 22 64
  4. HOXA5 regulates hMLH1 expression in breast cancer cells. (PMID: 16756717) Duriseti S. … Raman V. (Neoplasia 2006) 3 22 64
  5. Expression pattern of a homeotic gene, HOXA5, in normal breast and in breast tumors. (PMID: 17167183) Henderson G.S. … Raman V. (Cell. Oncol. 2006) 3 22 64

Products for HOXA5 Gene

Sources for HOXA5 Gene

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