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HOXA5 Gene

protein-coding   GIFtS: 59
GCID: GC07M027180

Homeobox A5

(Previous name: homeo box A5)
(Previous symbols: HOX1C, HOX1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox A51 2     HOX1.32
HOX1C1 2 3 5     Homeo Box 1C2
HOX11 2     Homeobox Protein Hox-A52
Homeo Box A51 2     Homeobox Protein HOXA52
Homeobox Protein Hox-1C2 3     

External Ids:    HGNC: 51061   Entrez Gene: 32022   Ensembl: ENSG000001060047   OMIM: 1429525   UniProtKB: P207193   

Export aliases for HOXA5 gene to outside databases

Previous GC identifers: GC07M026823 GC07M026923 GC07M026954 GC07M027147 GC07M027061


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXA5 Gene:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters
named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally
regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a
DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the
tumor suppressor p53, this protein may play an important role in tumorigenesis. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXA5 Gene:
HOXA5 (homeobox A5) is a protein-coding gene. Diseases associated with HOXA5 include gray zone lymphoma, and vacterl association. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot: HXA5_HUMAN, P20719
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds
specifically to the motif 5'-CYYNATTA[TG]Y-3'

Gene Wiki entry for HOXA5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXA5 gene promoter:
         Sp1   c-Myb   AP-2beta   AP-2gamma   AP-2alpha   FOXO1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXA5 promoter sequence
   Search Chromatin IP Primers for HOXA5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027180:  view genomic region     (about GC identifiers)

Start:
27,180,671 bp from pter      End:
27,183,287 bp from pter
Size:
2,617 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,231,823-27,234,436     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXA5_HUMAN, P20719 (See protein sequence)
Recommended Name: Homeobox protein Hox-A5  
Size: 270 amino acids; 29345 Da
Developmental stage: Expressed during embryogenesis and in adult kidney
Secondary accessions: A4D179 O43367 Q96CY6

Explore the universe of human proteins at neXtProt for HOXA5: NX_P20719

Explore proteomics data for HOXA5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys212
  • Modification sites at PhosphoSitePlus

  • See HOXA5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061975.2  
    ENSEMBL proteins: 
     ENSP00000222726  

    HOXA5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for HOXA5
    Cloud-Clone Corp. CLIAs for HOXA5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom

    Graphical View of Domain Structure for InterPro Entry P20719

    ProtoNet protein and cluster: P20719

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXA5_HUMAN, P20719
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXA5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXA5_HUMAN, P20719
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds
    specifically to the motif 5'-CYYNATTA[TG]Y-3'

         Genatlas biochemistry entry for HOXA5:
    homeo box A5(1C),homologous to mouse Hox-1.3,Drosophila Scr,expressed during early myelopoiesis,involved in the
    regulation of hematopoietic lineage determination and maturation,inhibiting erythropoiesis and promoting
    myelopoiesis

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA8657138
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10879542
    GO:0005515protein binding IPI15545268
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXA5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXA5:
     Decreased viability with pacli 

         15 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hoxa5):
     cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  normal  respiratory system  skeleton  vision/eye 

    HOXA5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXA5: Hoxa5tm1Rob Hoxa5tm1Ljea Hoxa5tm1.2Ljea

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXA5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXA5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXA5

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXA5:
    hsa-mir-19b-3p (MIRT031182), hsa-mir-374b-5p (MIRT016043), hsa-mir-19a-3p (MIRT001794), hsa-mir-484 (MIRT016627), hsa-mir-183-5p (MIRT025008), hsa-mir-196a-5p (MIRT006906), hsa-mir-130a-3p (MIRT000958), hsa-mir-92a-3p (MIRT049277), hsa-mir-340-5p (MIRT019581), hsa-mir-130b-3p (MIRT020201)

    Block miRNA regulation of human, mouse, rat HOXA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXA5 (see all 55):
    hsa-miR-4328 hsa-miR-429 hsa-miR-517a hsa-miR-513a-5p hsa-miR-517c hsa-miR-128 hsa-miR-16-1* hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidHOXA5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXA5
    Predesigned siRNA for gene silencing in human, mouse, rat HOXA5

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for HOXA5

    Clone
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    OriGene clones in human, mouse for HOXA5 (see all 8)
    OriGene ORF clones in mouse, rat for HOXA5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXA5 (NM_019102)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXA5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA5

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    GenScript Custom overexpressing Cell Line Services for HOXA5
    Browse ESI BIO Cell Lines and PureStem Progenitors for HOXA5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXA5_HUMAN, P20719: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15545268

    HOXA5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXA5: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HOXA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HOXA5 (P207193 ENSP000002227264) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOXO1Q127783, ENSP000003688804I2D: score=2 STRING: ENSP00000368880
    MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
    CDX4O146273, ENSP000003626134I2D: score=1 STRING: ENSP00000362613
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    PBX1P404243, ENSP000004058904I2D: score=2 STRING: ENSP00000405890
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development ----
    GO:0002009morphogenesis of an epithelium ----
    GO:0003016respiratory system process IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----

    HOXA5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXA5 (HXA5)

    2 Novoseek inferred chemical compound relationships for HOXA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 16.9 3 11501577 (1), 8838863 (1)
    progesterone 6.35 4 10875927 (3), 17167183 (1)



    HOXA5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOXA5 gene: 
    NM_019102.3  

    Unigene Cluster for HOXA5:

    Homeobox A5
    Hs.655218  [show with all ESTs]
    Unigene Representative Sequence: NM_019102
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222726(uc003syn.2) ENST00000520854
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXA5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXA5 (see all 55):
    hsa-miR-4328 hsa-miR-429 hsa-miR-517a hsa-miR-513a-5p hsa-miR-517c hsa-miR-128 hsa-miR-16-1* hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidHOXA5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXA5
    Predesigned siRNA for gene silencing in human, mouse, rat HOXA5
    Clone
    Products:
         
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: HOXA5 (NM_019102)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA5
    Primer
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    OriGene qPCR primer pairs and template standards for HOXA5
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXA5
      QuantiTect SYBR Green Assays in human, mouse, rat HOXA5
      QuantiFast Probe-based Assays in human, mouse, rat HOXA5

    Additional mRNA sequence: 

    BC013682.1 BT009744.1 CR542256.1 CR542277.1 

    1 DOTS entry:

    DT.213953 

    Selected AceView cDNA sequences (see all 57):

    BE871142 BC013682 BI822268 BU152995 CA442176 CR542256 AI081840 BX281623 
    NM_019102 CR542277 BI837164 BQ109393 T29089 BT009744 AI370985 AW663882 
    N75430 BM548694 AA909614 AI184862 AA788595 BV184263 BI490076 AI370899 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCTGTTTA
    HOXA5 Expression
    About this image


    HOXA5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Motor Neurons (Nervous System)
             Lateral motor column neuron-like cells
     
     Tendon & Ligament
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Bone (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Cartilage (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Somite (Muscoskeletal System)
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
    HOXA5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXA5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655218
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXA5: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HOXA5
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXA5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXA5
    QuantiTect SYBR Green Assays in human, mouse, rat HOXA5
    QuantiFast Probe-based Assays in human, mouse, rat HOXA5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOXA5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxa51 , 5 homeobox A51, 5 94.57(n)1
    97.78(a)1
      6 (25.40 cM)5
    154021  NM_010453.51  NP_034583.11 
     522017545 
    chicken
    (Gallus gallus)
    Aves LOC1008588341 homeobox protein Hox-A5-like 84.51(n)
    85.13(a)
      100858834  XM_003640705.2  XP_003640753.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXA56
    homeobox A5
    66(a)
    1 ↔ 1
    GL343275.1(1471904-1474322)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hoxa51 homeobox A5 79.73(n)
    81.34(a)
      496880  NM_001011405.1  NP_001011405.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxa5a1 homeo box A5a 68.31(n)
    68.61(a)
      58055  NM_131540.1  NP_571615.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dfd3 induction of apoptosis transcription
    factor
    76(a)
    (best of 2)
      3 84A5   --


    ENSEMBL Gene Tree for HOXA5 (if available)
    TreeFam Gene Tree for HOXA5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXA5 gene
    HOXA72  HOXB52  HOXC62  HOXC52  HOXB42  ENSG000002732662  HOXA42  HOXC82  
    HOXA62  ENSG000002730492  HOXD82  HOXB62  HOXB82  HOXD42  HOXB72  HOXC42  
    16 SIMAP similar genes for HOXA5 using alignment to 2 protein entries:     HXA5_HUMAN (see all proteins):
    HOX B6    HOXA4    HOXC13    HOXB5    HOXB1    HOXC6
    HOXB6    HOXA6    HOXC5    HOXD4    HOXC4    HOXB7
    HOXA7    HOXA-9    HOXD8    HOXB4

    HOXA5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    7 SNPs for HOXA5    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887486271,2
    C--27065748(+) CATGCA/GGCGGT 1 -- us2k10--------
    rs744177741,2
    C--27065755(+) CGGTTC/TTGGAA 1 -- us2k10--------
    rs3734149721,2
    ----27065808(+) GATCTC/TGATGC 1 -- us2k10--------
    rs1414749131,2
    ----27065799(+) CGCGTT/AGGCGA 1 -- us2k11Minor allele frequency- A:0.00NA 4550
    rs3700240611,2
    ----27065711(+) GCGTGA/GAATTG 1 -- us2k10--------
    rs3691499651,2
    ----27065778(+) CTGGCG/TCTCGG 1 -- us2k10--------
    rs3758765841,2
    ----27065717(+) AATTGA/GTGAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOXA5 (27180671 - 27183287 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HOXA5 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887856CNV Loss21882294
    nsv887876CNV Loss21882294
    nsv5674CNV Loss18451855
    dgv7233n71CNV Loss21882294
    dgv7231n71CNV Loss21882294
    nsv526526CNV Loss19592680
    dgv7235n71CNV Loss21882294
    dgv7236n71CNV Loss21882294
    dgv7234n71CNV Loss21882294
    dgv7232n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142952    OMIM disorders: --

    Selected diseases for HOXA5 (see all 23):    
    About MalaCards
    gray zone lymphoma    vacterl association    clubfoot    primary pulmonary hypertension
    acute lymphocytic leukemia    dwarfism    oral squamous cell carcinoma    esophageal squamous cell carcinoma
    teratocarcinoma    bronchiolitis    acute myeloid leukemia    clear cell renal cell carcinoma
    squamous cell carcinoma    hypertension    renal cell carcinoma    myeloid leukemia
    esophagitis    lung cancer    breast cancer    leukemia

    2 diseases from the University of Copenhagen DISEASES database for HOXA5:
    VACTERL association     Gray zone lymphoma

    HOXA5 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for HOXA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 47.4 1 7546287 (1)
    leukemia 43 4 18388181 (1), 16921363 (1), 17379095 (1)
    breast carcinoma 31.5 4 17167183 (2), 10875927 (1), 14701762 (1)
    breast cancer 28.5 8 10879542 (2), 10875927 (2), 11501577 (1), 14701762 (1) (see all 6)
    tumors 4.74 9 17167183 (3), 19424076 (1), 20042682 (1), 16525661 (1) (see all 5)
    carcinoma squamous cell 4.09 2 16525661 (2)
    cancer 0 1 10879542 (1)

    Genetic Association Database (GAD): HOXA5
    Human Genome Epidemiology (HuGE) Navigator: HOXA5 (3 documents)

    Export disorders for HOXA5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXA5 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with HOXA5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    2. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    8. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (Genome 1989)
    9. Remarkable intron and exon sequence conservation in human and mouse homeobox Hox 1.3 genes. (PubMed id 2568583)1, 2 Tournier-Lasserve E....Lazzarini R.A. (Mol. Cell. Biol. 1989)
    10. Expression pattern of a homeotic gene, HOXA5, in normal breast and in breast tumors. (PubMed id 17167183)1, 9 Henderson G.S....Raman V. (Cell. Oncol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 3202 HGNC: 5106 AceView: HOXA5 Ensembl:ENSG00000106004 euGenes: HUgn3202
    ECgene: HOXA5 H-InvDB: HOXA5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HOXA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HOXA5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HOXA5 gene:
    Search GeneIP for patents involving HOXA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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