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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXA5 Gene

protein-coding   GIFtS: 57
GCID: GC07M027180

homeobox A5

(Previous name: homeo box A5 )
(Previous symbols: HOX1C, HOX1)
 Explore 25 diseases affiliated with
HOXA5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXA5    

Aliases
for HOXA5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox A51 2     HOX1.32
HOX1C1 2 3 5     Homeo Box 1C2
HOX11 2     Homeobox Protein Hox-A52
Homeo Box A51 2     Homeobox Protein HOXA52
Homeobox Protein Hox-1C2 3     

External Ids:    HGNC: 51061   Entrez Gene: 32022   Ensembl: ENSG000001060047   OMIM: 1429525   UniProtKB: P207193   

Export aliases for HOXA5 gene to outside databases

Previous GC identifers: GC07M026823 GC07M026923 GC07M026954 GC07M027147 GC07M027061


Summaries
for HOXA5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXA5:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named
A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during
embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription
factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in
the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play
an important role in tumorigenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXA5_HUMAN, P20719
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically
to the motif 5'-CYYNATTA[TG]Y-3'

Gene Wiki entry for HOXA5


Genomic Views
for HOXA5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXA5 gene promoter:
         Sp1   c-Myb   AP-2beta   AP-2gamma   AP-2alpha   FOXO1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOXA5 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXA5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXA5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027180:  view genomic region     (about GC identifiers)

Start:
 27,180,671 bp from pter      End:
 27,183,287 bp from pter
Size:
 2,617 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,232,145-27,234,436     

Proteins
for HOXA5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXA5_HUMAN, P20719 (See protein sequence)
Recommended Name: Homeobox protein Hox-A5  
Size: 270 amino acids; 29345 Da
Subcellular location: Nucleus
Developmental stage: Expressed during embryogenesis and in adult kidney
Secondary accessions: A4D179 O43367 Q96CY6

Explore the universe of human proteins at neXtProt for HOXA5: NX_P20719

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P20719

    • HOXA5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061975.2  
    ENSEMBL proteins: 
     ENSP00000222726  

    Human Recombinant Protein Products: 
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    Novus Biologicals HOXA5 Protein
    Novus Biologicals HOXA5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXA5

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15545268


    HOXA5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HOXA5

    Protein Domains /
    Families
    for HOXA5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXA5 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry P20719

    ProtoNet protein and cluster: P20719

    1 Blocks protein family: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXA5_HUMAN, P20719
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXA5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXA5_HUMAN, P20719
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically
    to the motif 5'-CYYNATTA[TG]Y-3'

         Genatlas biochemistry entry for HOXA5:
    homeo box A5(1C),homologous to mouse Hox-1.3,Drosophila Scr,expressed during early myelopoiesis,involved in the
    regulation of hematopoietic lineage determination and maturation,inhibiting erythropoiesis and promoting myelopoiesis

    10/570 SABiosciences Target genes for HOXA5 (see all 570):
    ABP1 ABTB1 ACCSL ACOT9 ACTL6B ADAM30 ADPGK ADRM1 AGBL4 AGXT2

    miRNA
    Products:            		miRTarBase miRNAs that target HOXA5:
    hsa-mir-19a (MIRT001794), hsa-mir-130a (MIRT000958)

    OriGene 3'-UTR Clone: HOXA5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXA5
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA5 (see all 55):
    hsa-miR-4328 hsa-miR-429 hsa-miR-517a hsa-miR-513a-5p hsa-miR-517c hsa-miR-128 hsa-miR-16-1* hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmid: HOXA5 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXA5 (see all 4)
    OriGene shRNA RFP: HOXA5
    OriGene siRNA: HOXA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXA5

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXA5

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA5 (see all 2)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA5 

    Cell Line
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    Search LifeMap BioReagents cell lines for HOXA5

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA8657138
    GO:0003700sequence-specific DNA binding transcription factor activity IDA10879542
    GO:0005515protein binding IPI15545268
    GO:0043565sequence-specific DNA binding IEA--


    HOXA5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HOXA5:
     Decreased viability with pacli 

    Animal Models:
         Mouse knock-outs for HOXA5: Hoxa5tm1Rob Hoxa5tm1Ljea Hoxa5tm1.2Ljea
         15 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Hoxa5):
     cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland  growth/size 
     hearing/vestibular/ear  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     no phenotypic analysis  normal  respiratory system  skeleton  vision/eye 

    HOXA5 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXA5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXA5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/15 Interacting proteins for HOXA5 (P207193 ENSP000002227264) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FOXO1Q127783, ENSP000003688804I2D: score=2 STRING: ENSP00000368880
    MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
    CDX4O146273, ENSP000003626134I2D: score=1 STRING: ENSP00000362613
    GTF2A1LQ9UNN43, ENSP000003845974I2D: score=1 STRING: ENSP00000384597
    FOXA2Q9Y2613, ENSP000003159554I2D: score=2 STRING: ENSP00000315955
    About this table

    Gene Ontology (GO): 5/34 biological process terms (GO ID links to tree view) (see all 34):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development ----
    GO:0002009morphogenesis of an epithelium ----
    GO:0003016respiratory system process IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007389pattern specification process ----


    HOXA5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXA5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXA5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXA5
    2 Novoseek chemical compound relationships for HOXA5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 16.9 3 11501577 (1), 8838863 (1)
    progesterone 6.35 4 10875927 (3), 17167183 (1)

    Search CenterWatch for drugs/clinical trials and news about HOXA5 / HXA5 

    Transcripts
    for HOXA5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXA5 gene: 
    NM_019102.3  

    Unigene Cluster for HOXA5:

    Homeobox A5
    Hs.655218  [show with all ESTs]
    Unigene Representative Sequence: NM_019102
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222726(uc003syn.2) ENST00000520854

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HOXA5
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXA5
    8/55 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA5 (see all 55):
    hsa-miR-4328 hsa-miR-429 hsa-miR-517a hsa-miR-513a-5p hsa-miR-517c hsa-miR-128 hsa-miR-16-1* hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmid: HOXA5 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXA5 (see all 4)
    OriGene shRNA RFP: HOXA5
    OriGene siRNA: HOXA5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXA5
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA5 (see all 2)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXA5 (NM_019102)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXA5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXA5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXA5

    Additional cDNA sequence: 

    BC013682.1 BT009744.1 CR542256.1 CR542277.1 

    1 DOTS entry:

    DT.213953 

    24/57 AceView cDNA sequences (see all 57):

    CA442176 AI081840 NM_019102 BC013682 BE871142 BU152995 BI822268 CR542256 
    BX281623 AI184862 AA909614 AI370899 BI819553 CR542277 BT009744 BI490076 
    AA788595 BM548694 BQ109393 AI370985 AW663882 T29089 BI837164 BV184263 

    GeneLoc Exon Structure


    Expression
    for HOXA5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXA5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGCCTGTTTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXA5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    SomiteCervical Mesenchymal SclerotomeCervical Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    LungLung MesodermDistal Mesodermal Progenitor CellsLung
    LungLung MesodermEarly Lung Mesoderm CellsLung
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    HeartAtrioventricular CanalHeart
    LimbLimb BudLimb
    LungLung BudLung
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

    See HOXA5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXA5

    SOURCE GeneReport for Unigene cluster: Hs.655218
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXA5: 
              Polycomb & Trithorax Target Genes in human mouse rat
              Transcription Factors in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXA5
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA5

    Orthologs
    for HOXA5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXA5 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXA51 homeobox A5 83.95(n)
    83.7(a)    		   100858404  XM_003640699.1  XP_003640747.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXA56
    		 --
    		 69(a)
    		 1 ↔ 1
    		 GL343275.1(1471904-1474245)
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxa5a1 homeo box A5a 69.06(n)
    68.61(a)    		   58055  NM_131540.1  NP_571615.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dfd3 induction of apoptosis transcription factor 76(a)
    (best of 2)    		   3 84A5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-396
    		 Homeobox protein lin-39
    		 24(a)
    		 possible ortholog
    		 III(7528603-7536567)


    ENSEMBL Gene Tree for HOXA5 (if available)
    TreeFam Gene Tree for HOXA5 (if available) 

    Paralogs
    for HOXA5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXA5 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXB42  HOXA42  HOXD32  HOXA62  HOXC82  HOXA32  
    HOXD82  HOXB12  HOXB62  HOXB82  HOXD42  HOXB22  HOXB72  PDX12  
    HOXC42  
    16 SIMAP similar genes for HOXA5 using alignment to 2 protein entries:     HXA5_HUMAN (see all proteins):
    HOX B6    HOXA4    HOXC13    HOXB5    HOXB1    HOXC6
    HOXB6    HOXA6    HOXC5    HOXD4    HOXC4    HOXB7
    HOXA7    HOXA-9    HOXD8    HOXB4

    HOXA5 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXA5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/99 NCBI SNPs in HOXA5 are shown (see all 99)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs744177741,2
    		C,--27065755(+) CGGTTC/TTGGAA 1 -- us2k10--------
    rs1162117741,2
    		--27180216(+) GTCCCG/AGGTGA 2 -- int1 ds50011Minor allele frequency- A:0.01WA 118
    rs1850900251,2
    		--27180254(+) TTAAGA/GGCAGA 2 -- int1 ds50010--------
    rs2009176601,2
    		--27180379(+) TTTTT-/TCTCCTT 2 -- int1 ds50010--------
    rs771478381,2
    		C,--27180380(+) TTTTTCTC/-CTTTT 2 -- ds5001 int11Minor allele frequency- -:0.50CSA 2
    rs174720001,2
    		C--27180381(+) TTTTC-/TCCTTT 2 -- int1 ds50010--------
    rs105313281,2
    		C--27180382(+) TTTCT-/CCTTTTTT 2 -- int1 ds50011Minor allele frequency- CCT:0.00NA 2
    rs793007431,2
    		C,--27180382(+) TTTCTC/TCTTTT 2 -- int1 ds50010--------
    rs1906682481,2
    		--27180558(+) GGTCTC/GCCTGC 2 -- ds5001 int10--------
    rs134380401,2
    		C,H--27180586(+) GTAGCC/TTCAGA 2 -- ds5001 int16Minor allele frequency- T:0.00NS EA NA 402

    HapMap Linkage Disequilibrium report for HOXA5 (27180671 - 27183287 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HOXA5: --

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    Disorders / Diseases
    for HOXA5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXA5 for disorders           About GeneDecksing

    OMIM gene information: 142952    OMIM disorders: --

    20/25 diseases for HOXA5 (see all 25):    About MalaCards
    gray zone lymphoma    vacterl association    esophageal squamous cell carcinoma    primary pulmonary hypertension
    squamous cell carcinoma    pulmonary hypertension    acute lymphocytic leukemia    acute myeloid leukemia
    lymphocytic leukemia    myeloid leukemia    clubfoot    renal cell carcinoma
    dwarfism    embryonal carcinoma    teratocarcinoma    emphysema
    hypertension    carcinoma    leukemia    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for HOXA5:
    VACTERL association     Gray zone lymphoma

    7 Novoseek disease relationships for HOXA5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma embryonal 47.4 1 7546287 (1)
    leukemia 43 4 18388181 (1), 16921363 (1), 17379095 (1)
    breast carcinoma 31.5 4 17167183 (2), 10875927 (1), 14701762 (1)
    breast cancer 28.5 8 10879542 (2), 10875927 (2), 11501577 (1), 14701762 (1) (see all 6)
    tumors 4.74 9 17167183 (3), 19424076 (1), 20042682 (1), 16525661 (1) (see all 5)
    carcinoma squamous cell 4.09 2 16525661 (2)
    cancer 0 1 10879542 (1)

    Human Genome Epidemiology (HuGE) Navigator: HOXA5 (3 documents)

    Export disorders for HOXA5 gene to outside databases

    Publications
    for HOXA5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXA5 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with HOXA5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    6. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    7. Remarkable intron and exon sequence conservation in human and mouse homeobox Hox 1.3 genes. (PubMed id 2568583)1, 2 Tournier-Lasserve E....Lazzarini R.A. (1989)
    8. Expression pattern of a homeotic gene, HOXA5, in normal breast and in breast tumors. (PubMed id 17167183)1, 9 Henderson G.S....Raman V. (2006)
    9. HOXA5 regulates expression of the progesterone receptor. (PubMed id 10875927)1, 9 Raman V....Sukumar S. (2000)
    10. Identification of transcriptional targets of HOXA5. (PubMed id 15757903)1, 9 Chen H....Sukumar S. (2005)

    External Searches for HOXA5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXA5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3202 HGNC: 5106 AceView: HOXA5 Ensembl:ENSG00000106004 euGenes: HUgn3202
    ECgene: HOXA5 H-InvDB: HOXA5

    Other Databases showing HOXA5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXA5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXA5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HOXA5 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HOXA5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXA5 gene:
    Search GeneIP for patents involving HOXA5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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