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Aliases for HOXA5 Gene

Aliases for HOXA5 Gene

  • Homeobox A5 2 3
  • HOX1C 3 4 6
  • Homeobox Protein Hox-1C 3 4
  • Homeo Box A5 2 3
  • Homeobox Protein Hox-A5 3
  • Homeobox Protein HOXA5 3
  • Homeo Box 1C 3
  • HOX1.3 3
  • HOX1 3

External Ids for HOXA5 Gene

Previous HGNC Symbols for HOXA5 Gene

  • HOX1C
  • HOX1

Previous GeneCards Identifiers for HOXA5 Gene

  • GC07M026823
  • GC07M026923
  • GC07M026954
  • GC07M027147
  • GC07M027061
  • GC07M027180

Summaries for HOXA5 Gene

Entrez Gene Summary for HOXA5 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA5 Gene

HOXA5 (Homeobox A5) is a Protein Coding gene. Diseases associated with HOXA5 include gray zone lymphoma and vacterl association. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXA5 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5-CYYNATTA[TG]Y-3

Gene Wiki entry for HOXA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA5 Gene

Genomics for HOXA5 Gene

Regulatory Elements for HOXA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXA5 Gene

Start:
27,141,052 bp from pter
End:
27,143,668 bp from pter
Size:
2,617 bases
Orientation:
Minus strand

Genomic View for HOXA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA5 Gene

Proteins for HOXA5 Gene

  • Protein details for HOXA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20719-HXA5_HUMAN
    Recommended name:
    Homeobox protein Hox-A5
    Protein Accession:
    P20719
    Secondary Accessions:
    • A4D179
    • O43367
    • Q96CY6

    Protein attributes for HOXA5 Gene

    Size:
    270 amino acids
    Molecular mass:
    29345 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA5 Gene

Proteomics data for HOXA5 Gene at MOPED

Post-translational modifications for HOXA5 Gene

  • Ubiquitination at Lys212
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXA5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXA5 Gene

Domains for HOXA5 Gene

Gene Families for HOXA5 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXA5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20719

UniProtKB/Swiss-Prot:

HXA5_HUMAN :
  • P20719
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXA5: view

Function for HOXA5 Gene

Molecular function for HOXA5 Gene

GENATLAS Biochemistry: homeo box A5(1C),homologous to mouse Hox-1.3,Drosophila Scr,expressed during early myelopoiesis,involved in the regulation of hematopoietic lineage determination and maturation,inhibiting erythropoiesis and promoting myelopoiesis
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5-CYYNATTA[TG]Y-3

Gene Ontology (GO) - Molecular Function for HOXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10879542
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 10879542
GO:0003677 DNA binding IDA 8657138
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 10879542
GO:0005515 protein binding IPI 15545268
genes like me logo Genes that share ontologies with HOXA5: view
genes like me logo Genes that share phenotypes with HOXA5: view

Animal Models for HOXA5 Gene

MGI Knock Outs for HOXA5:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXA5 Gene

Localization for HOXA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA5 Gene COMPARTMENTS Subcellular localization image for HOXA5 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15545268
genes like me logo Genes that share ontologies with HOXA5: view

Pathways for HOXA5 Gene

SuperPathways for HOXA5 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HOXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development --
GO:0002009 morphogenesis of an epithelium --
GO:0003016 respiratory system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007389 pattern specification process --
genes like me logo Genes that share ontologies with HOXA5: view

No data available for Pathways by source for HOXA5 Gene

Compounds for HOXA5 Gene

(2) Novoseek inferred chemical compound relationships for HOXA5 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 16.9 2
progesterone 6.35 4
genes like me logo Genes that share compounds with HOXA5: view

Transcripts for HOXA5 Gene

mRNA/cDNA for HOXA5 Gene

(4) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXA5 Gene

Homeobox A5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXA5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA5 Gene

No ASD Table

Relevant External Links for HOXA5 Gene

GeneLoc Exon Structure for
HOXA5
ECgene alternative splicing isoforms for
HOXA5

Expression for HOXA5 Gene

mRNA expression in normal human tissues for HOXA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA5 Gene

This gene is overexpressed in Fallopian Tube (6.8) and Adrenal Gland (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOXA5 Gene

SOURCE GeneReport for Unigene cluster for HOXA5 Gene Hs.655218

genes like me logo Genes that share expressions with HOXA5: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXA5 Gene

Orthologs for HOXA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA5 35
  • 99.63 (n)
  • 99.26 (a)
HOXA5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXA5 35
  • 97.41 (n)
  • 98.52 (a)
HOXA5 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXA5 35
  • 97.16 (n)
  • 98.52 (a)
HOXA5 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxa5 35
  • 94.57 (n)
  • 97.78 (a)
Hoxa5 16
Hoxa5 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXA5 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA5 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909641 35
  • 94.94 (n)
  • 97.78 (a)
chicken
(Gallus gallus)
Aves HOXA5 36
  • 85 (a)
OneToMany
HOXA5 36
  • 85 (a)
OneToMany
HOXA5 36
  • 85 (a)
OneToMany
LOC100858834 35
  • 84.51 (n)
  • 85.13 (a)
lizard
(Anolis carolinensis)
Reptilia HOXA5 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa5 35
  • 79.73 (n)
  • 81.34 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxa5a 35
  • 68.31 (n)
  • 68.61 (a)
hoxa5a 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ftz 36
  • 20 (a)
OneToMany
Dfd 37
  • 76 (a)
Scr 37
  • 74 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for HOXA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA5 Gene

ENSEMBL:
Gene Tree for HOXA5 (if available)
TreeFam:
Gene Tree for HOXA5 (if available)

Paralogs for HOXA5 Gene

Selected SIMAP similar genes for HOXA5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXA5: view

Variants for HOXA5 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXA5 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7232n71 CNV Loss 21882294
dgv7233n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
dgv7235n71 CNV Loss 21882294
nsv5674 CNV Loss 18451855
nsv887876 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7236n71 CNV Loss 21882294
nsv526526 CNV Loss 19592680

Relevant External Links for HOXA5 Gene

HapMap Linkage Disequilibrium report
HOXA5
Human Gene Mutation Database (HGMD)
HOXA5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for HOXA5 Gene

Disorders for HOXA5 Gene

(2) University of Copenhagen DISEASES for HOXA5 Gene

(7) Novoseek inferred disease relationships for HOXA5 Gene

Disease -log(P) Hits PubMed IDs
carcinoma embryonal 47.4 1
leukemia 43 3
breast carcinoma 31.5 4
breast cancer 28.5 8
tumors 4.74 7

Relevant External Links for HOXA5

Genetic Association Database (GAD)
HOXA5
Human Genome Epidemiology (HuGE) Navigator
HOXA5
genes like me logo Genes that share disorders with HOXA5: view

No data available for UniProtKB/Swiss-Prot for HOXA5 Gene

Publications for HOXA5 Gene

  1. Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex. (PMID: 8657138) Lu Q. … Kamps M.P. (Mol. Cell. Biol. 1996) 3 23
  2. HOXA5 regulates expression of the progesterone receptor. (PMID: 10875927) Raman V. … Sukumar S. (J. Biol. Chem. 2000) 3 23
  3. Compromised HOXA5 function can limit p53 expression in human breast tumours. (PMID: 10879542) Raman V. … Sukumar S. (Nature 2000) 3 23
  4. HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8. (PMID: 14701762) Chen H. … Sukumar S. (Mol. Cell. Biol. 2004) 3 23
  5. Identification of transcriptional targets of HOXA5. (PMID: 15757903) Chen H. … Sukumar S. (J. Biol. Chem. 2005) 3 23

Products for HOXA5 Gene

  • Addgene plasmids for HOXA5

Sources for HOXA5 Gene

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