Aliases for HOXA4 Gene
Aliases for HOXA4 Gene
External Ids for HOXA4 Gene
- HGNC: 5105
- Entrez Gene: 3201
- Ensembl: ENSG00000197576
- OMIM: 142953
- UniProtKB: Q00056
Previous HGNC Symbols for HOXA4 Gene
- HOX1D
- HOX1
Previous GeneCards Identifiers for HOXA4 Gene
- GC07M026810
- GC07M026911
- GC07M026912
- GC07M026941
- GC07M027134
- GC07M027048
- GC07M027170
Summaries for HOXA4 Gene
-
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA4 Gene
HOXA4 (Homeobox A4) is a Protein Coding gene. Diseases associated with HOXA4 include Hypospadias. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXD4.
UniProtKB/Swiss-Prot for HOXA4 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5-TAATGA[CG]-3 and 5-CTAATTTT-3.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA4 Gene
Genomics for HOXA4 Gene
Regulatory Elements for HOXA4 Gene
Enhancers for HOXA4 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXA4 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXA4 gene promoter:
Regulatory Element Products
Genomic Location for HOXA4 Gene
- Chromosome:
- 7
- Start:
- 27,128,507 bp from pter
- End:
- 27,130,799 bp from pter
- Size:
- 2,293 bases
- Orientation:
- Minus strand
Genomic View for HOXA4 Gene
Genes around HOXA4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
HOXA4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXA4 Gene
Proteins for HOXA4 Gene
-
Protein details for HOXA4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q00056-HXA4_HUMAN
- Recommended name:
- Homeobox protein Hox-A4
- Protein Accession:
- Q00056
- A4D180
- O43366
Protein attributes for HOXA4 Gene
- Size:
- 320 amino acids
- Molecular mass:
- 34499 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXA4 Gene
Post-translational modifications for HOXA4 Gene
Other Protein References for HOXA4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOXA4
-
Abcam antibodies for HOXA4
- Invitrogen Antibodies for HOXA4
- antibodies-online Antibodies for HOXA4: See all 67
- GeneTex HOXA4 antibody for HOXA4
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXA4
Protein Products
-
OriGene Purified Proteins for HOXA4
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXA4
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- Novus Biologicals proteins for HOXA4
- antibodies-online Proteins for HOXA4: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXA4
-
Abcam proteins for HOXA4
Assay Products
No data available for DME Specific Peptides for HOXA4 Gene
Domains & Families for HOXA4 Gene
Gene Families for HOXA4 Gene
Protein Domains for HOXA4 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXA4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q00056- Family:
-
- Belongs to the Antp homeobox family. Deformed subfamily.
Function for HOXA4 Gene
Molecular function for HOXA4 Gene
- GENATLAS Biochemistry:
- homeo box A4(1D),homologous to mouse Hox-1.4,Drosophila Dfd
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5-TAATGA[CG]-3 and 5-CTAATTTT-3.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXA4 Gene
- MGI mutant phenotypes for HOXA4:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for HOXA4:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA4 gene
- Search ViGene Biosciences for HOXA4
CRISPR Products
-
OriGene CRISPR knockouts for HOXA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA4
- GenScript: Design CRISPR guide RNA sequences for HOXA4
miRNA Products
- Search ViGene Biosciences for HOXA4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXA4
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA4 gene
Clone Products
-
OriGene ORF clones in human for HOXA4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HOXA4
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXA4 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA4 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA4 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HOXA4 Gene
Localization for HOXA4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXA4 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for HOXA4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for HOXA4 Gene
Interacting Proteins for HOXA4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0009653 | anatomical structure morphogenesis | TAS | 1675427 |
No data available for SIGNOR curated interactions for HOXA4 Gene
Transcripts for HOXA4 Gene
mRNA/cDNA for HOXA4 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (81) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXA4
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA4
- GenScript: Design CRISPR guide RNA sequences for HOXA4
miRNA Products
- Search ViGene Biosciences for HOXA4
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXA4
- Browse OriGene Inhibitory RNA Products For HOXA4
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA4 gene
Clone Products
-
OriGene ORF clones in human for HOXA4
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HOXA4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
- Spinous Keratinocytes Stratified Epidermis
- Intermediate Keratinocytes Embryonic Epidermis
-
Epidermis (Integumentary System)
- Outer Root Sheath Progenitor Cells Embryonic Epidermis
- Spinous Keratinocytes Stratified Epidermis
- Intermediate Keratinocytes Embryonic Epidermis
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Outer Root Sheath Progenitor Cells Embryonic Epidermis
-
Bone (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Cartilage (Muscoskeletal System)
- Osteochondro Mesenchymal Cells Rib
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Somite (Muscoskeletal System)
- Sclerotome Cells Cervical Mesenchymal Sclerotome
- Thoracic Mesenchymal Sclerotome
- Neural Tube (Nervous System)
- Endothelium (Cardiovascular System)
-
Tendon amp Ligament
- Sclerotome Cells Cervical Mesenchymal Sclerotome
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for HOXA4 Gene
This gene is overexpressed in Esophagus - Muscularis (x7.3) and Esophagus - Gastroesophageal Junction (x6.8).
This gene is overexpressed in Neutrophil (23.8), Tlymphocyte (12.9), Nasal epithelium (10.8), and Blymphocyte (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA4 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXA4 Gene:
HOXA4SOURCE GeneReport for Unigene cluster for HOXA4 Gene:
Hs.533357mRNA Expression by UniProt/SwissProt for HOXA4 Gene:
Q00056-HXA4_HUMAN
Tissue specificity:
Embryonic nervous system.
Primer Products
-
OriGene qPCR primer pairs for HOXA4
No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA4 Gene
Orthologs for HOXA4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXA4 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXA4 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXA4 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100360577 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxa4 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXA4 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HOXA4 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100858429 34 |
|
||
| HOXA4 35 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | HOXA4 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxa4 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Dfd 36 35 |
|
||
| Scr 36 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXA4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for HOXA4 Gene
Paralogs for HOXA4 Gene
(55) SIMAP similar genes for HOXA4 Gene using alignment to 3 proteins:
- HOX B6
- HOXA6
- HOXB6
- HOXC6
- HOXB8
- MNX1
- HOXB4
- BARX2
- HOXD12
- HOXC13
- MEOX2
- HOXA5
- HOXA11
- HOXD8
- HOXA10
- BARX1
- HOXA7
- HOXB7
- HOXD4
- HOXB13
- GBX1
- HOXD11
- HOXB5
- NKX6-3
- HOXC5
- HOXC4
- NKX2-5
- HMX2
- HOXA13
- GSX2
- HOXA-9
- HOXB3
- HOX A1
- LBX1
- NOTO
- HMX1
- PITX1
- PAX6
- NKX1-2
- PITX2
- Pix-1
- NANOG
- NANOGP8
- NKX2-6
- MSX1
- DLX6
- DLX1
- BARHL1
- HOXB1
- PAX4
- NKX6-1
- EVX1
- DBX2
- TPRX1
- POU6F1
Variants for HOXA4 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_036266 | A breast cancer sample | ||||
| rs1001379085 | -- | 27,128,387(+) | AATTA(A/T)GTGAG | intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB | |
| rs1001544497 | -- | 27,128,830(+) | AGGTA(A/G)GGAAG | intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime | |
| rs1002143143 | -- | 27,128,852(+) | GTCTG(A/T)CTTCT | intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime | |
| rs1002822603 | -- | 27,132,201(+) | GGCAT(G/T)CAAAA | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.09;
80.48% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXA4 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA4 Gene
Disorders for HOXA4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypospadias |
|
|
Search HOXA4 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOXA4
No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA4 Gene
Publications for HOXA4 Gene
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias. (PMID: 17003840) Chen T. … Shen Y. (Eur. J. Hum. Genet. 2007) 3 46 64
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
- Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3 64
- Alteration of homeobox gene expression by N-ras transformation of PA- 1 human teratocarcinoma cells. (PMID: 1675427) Buettner R. … Tainsky M.A. (Mol. Cell. Biol. 1991) 3 4 64
Products for HOXA4 Gene
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXA4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
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- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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- (26) UniGene
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- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
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- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
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- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
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- (81) Reactome
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- (100) COMPARTMENTS
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