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Aliases for HOXA4 Gene

Aliases for HOXA4 Gene

  • Homeobox A4 2 3
  • HOX1D 3 4 6
  • Homeobox Protein Hox-1.4 3 4
  • Homeobox Protein Hox-1D 3 4
  • Homeo Box A4 2 3
  • Homeobox Protein Hox-A4 3
  • Hox-1.4-Like Protein 3
  • Dfd-Like Protein 3
  • HOX1 3

External Ids for HOXA4 Gene

Previous Symbols for HOXA4 Gene

  • HOX1D
  • HOX1

Summaries for HOXA4 Gene

Entrez Gene Summary for HOXA4 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA4 Gene

HOXA4 (Homeobox A4) is a Protein Coding gene. Diseases associated with HOXA4 include abdominal aortic aneurysm. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXA4 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5-TAATGA[CG]-3 and 5-CTAATTTT-3

Gene Wiki entry for HOXA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA4 Gene

Genomics for HOXA4 Gene

Genomic Location for HOXA4 Gene

Start:
27,128,507 bp from pter
End:
27,130,799 bp from pter
Size:
2,293 bases
Orientation:
Minus strand

Genomic View for HOXA4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA4 Gene

Regulatory Elements for HOXA4 Gene

Proteins for HOXA4 Gene

  • Protein details for HOXA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00056-HXA4_HUMAN
    Recommended name:
    Homeobox protein Hox-A4
    Protein Accession:
    Q00056
    Secondary Accessions:
    • A4D180
    • O43366

    Protein attributes for HOXA4 Gene

    Size:
    320 amino acids
    Molecular mass:
    34499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA4 Gene

Proteomics data for HOXA4 Gene at MOPED

Post-translational modifications for HOXA4 Gene

No Post-translational modifications

Other Protein References for HOXA4 Gene

No data available for DME Specific Peptides for HOXA4 Gene

Domains for HOXA4 Gene

Gene Families for HOXA4 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00056

UniProtKB/Swiss-Prot:

HXA4_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • Q00056
Family:
  • Belongs to the Antp homeobox family. Deformed subfamily.:
    • Q00056
genes like me logo Genes that share domains with HOXA4: view

Function for HOXA4 Gene

Molecular function for HOXA4 Gene

GENATLAS Biochemistry: homeo box A4(1D),homologous to mouse Hox-1.4,Drosophila Dfd
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5-TAATGA[CG]-3 and 5-CTAATTTT-3

Gene Ontology (GO) - Molecular Function for HOXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXA4: view

Phenotypes for HOXA4 Gene

genes like me logo Genes that share phenotypes with HOXA4: view

Animal Models for HOXA4 Gene

MGI Knock Outs for HOXA4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HOXA4 Gene

Localization for HOXA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA4 Gene COMPARTMENTS Subcellular localization image for HOXA4 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with HOXA4: view

Pathways for HOXA4 Gene

SuperPathways for HOXA4 Gene

No Data Available

Interacting Proteins for HOXA4 Gene

Gene Ontology (GO) - Biological Process for HOXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development --
GO:0009653 anatomical structure morphogenesis TAS 1675427
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with HOXA4: view

No data available for Pathways by source for HOXA4 Gene

Transcripts for HOXA4 Gene

mRNA/cDNA for HOXA4 Gene

Unigene Clusters for HOXA4 Gene

Homeobox A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA4 Gene

No ASD Table

Relevant External Links for HOXA4 Gene

GeneLoc Exon Structure for
HOXA4
ECgene alternative splicing isoforms for
HOXA4

Expression for HOXA4 Gene

mRNA expression in normal human tissues for HOXA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA4 Gene

This gene is overexpressed in Esophagus - Muscularis (7.3) and Esophagus - Gastroesophageal Junction (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOXA4 Gene

SOURCE GeneReport for Unigene cluster for HOXA4 Gene Hs.533357

mRNA Expression by UniProt/SwissProt for HOXA4 Gene

Q00056-HXA4_HUMAN
Tissue specificity: Embryonic nervous system
genes like me logo Genes that share expressions with HOXA4: view

Orthologs for HOXA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA4 35
  • 99.37 (n)
  • 99.06 (a)
HOXA4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXA4 35
  • 90.22 (n)
  • 88.96 (a)
HOXA4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXA4 35
  • 91.59 (n)
  • 90.54 (a)
HOXA4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxa4 35
  • 83.27 (n)
  • 77.54 (a)
Hoxa4 16
Hoxa4 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXA4 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA4 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360577 35
  • 83.99 (n)
  • 79.72 (a)
chicken
(Gallus gallus)
Aves HOXA4 36
  • 60 (a)
OneToMany
HOXA4 36
  • 60 (a)
OneToMany
LOC100858429 35
  • 94.44 (n)
  • 91.67 (a)
lizard
(Anolis carolinensis)
Reptilia HOXA4 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa4 35
  • 66.67 (n)
  • 65.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dfd 36
  • 20 (a)
OneToMany
Dfd 37
  • 73 (a)
Scr 37
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for HOXA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HOXA4 Gene

ENSEMBL:
Gene Tree for HOXA4 (if available)
TreeFam:
Gene Tree for HOXA4 (if available)

Paralogs for HOXA4 Gene

genes like me logo Genes that share paralogs with HOXA4: view

Variants for HOXA4 Gene

Sequence variations from dbSNP and Humsavar for HOXA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
VAR_028414 -
VAR_028415 -
VAR_028416 -
VAR_028417 -
VAR_028418 -

Structural Variations from Database of Genomic Variants (DGV) for HOXA4 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7232n71 CNV Loss 21882294
dgv7233n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
dgv7235n71 CNV Loss 21882294
nsv5674 CNV Loss 18451855
nsv887876 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7236n71 CNV Loss 21882294

Relevant External Links for HOXA4 Gene

HapMap Linkage Disequilibrium report
HOXA4
Human Gene Mutation Database (HGMD)
HOXA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA4 Gene

Disorders for HOXA4 Gene

Relevant External Links for HOXA4

Genetic Association Database (GAD)
HOXA4
Human Genome Epidemiology (HuGE) Navigator
HOXA4
genes like me logo Genes that share disorders with HOXA4: view

No data available for UniProtKB/Swiss-Prot for HOXA4 Gene

Publications for HOXA4 Gene

  1. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  2. Alteration of homeobox gene expression by N-ras transformation of PA- 1 human teratocarcinoma cells. (PMID: 1675427) Buettner R. … Tainsky M.A. (Mol. Cell. Biol. 1991) 3 4
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. Expression of HOX homeogenes in human neuroblastoma cell culture lines. (PMID: 1981366) Peverali F.A. … Boncinelli E. (Differentiation 1990) 3 4
  5. Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox. (PMID: 2571574) Ferguson-Smith A.C. … Ruddle F.H. (Genomics 1989) 3 4

Products for HOXA4 Gene

Sources for HOXA4 Gene

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