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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXA4 Gene

protein-coding   GIFtS: 54
GCID: GC07M027170

Homeobox A4

(Previous name: homeo box A4)
(Previous symbols: HOX1D, HOX1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Homeobox A41 2     Homeobox Protein Hox-1D2 3
HOX1D1 2 3 5     Dfd-Like Protein2
HOX11 2     Homeobox Protein Hox-A42
Homeo Box A41 2     Hox-1.4-Like Protein2
Homeobox Protein Hox-1.42 3     

External Ids:    HGNC: 51051   Entrez Gene: 32012   Ensembl: ENSG000001975767   OMIM: 1429535   UniProtKB: Q000563   

Export aliases for HOXA4 gene to outside databases

Previous GC identifers: GC07M026810 GC07M026911 GC07M026912 GC07M026941 GC07M027134 GC07M027048


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOXA4 Gene:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters
named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally
regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a
DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
(provided by RefSeq, Jul 2008)

GeneCards Summary for HOXA4 Gene: 
HOXA4 (homeobox A4) is a protein-coding gene. Diseases associated with HOXA4 include megacolon, and abdominal aortic aneurysm. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXA4_HUMAN, Q00056
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking
sequence of its coding region with various affinities. The consensus sequences of the high and low affinity
binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'

Gene Wiki entry for HOXA4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXA4 gene promoter:
         Sp1   c-Myb   AP-2beta   AP-2alpha   AP-2gamma   FOXO1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOXA4 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXA4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXA4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027170:  view genomic region     (about GC identifiers)

Start:
27,168,126 bp from pter      End:
27,170,418 bp from pter
Size:
2,293 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,219,281-27,221,554     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HXA4_HUMAN, Q00056 (See protein sequence)
Recommended Name: Homeobox protein Hox-A4  
Size: 320 amino acids; 34499 Da
Subcellular location: Nucleus
Secondary accessions: A4D180 O43366

Explore the universe of human proteins at neXtProt for HOXA4: NX_Q00056

Explore proteomics data for HOXA4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q00056

  • HOXA4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOXA4 Protein Expression
    REFSEQ proteins: NP_002132.3  
    ENSEMBL proteins: 
     ENSP00000353151   ENSP00000448015   ENSP00000408845  

    Human Recombinant Protein Products for HOXA4: 
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    Novus Biologicals HOXA4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOXA4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    HOXA4 for ontologies           About GeneDecksing



    HOXA4 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for HOXA4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017995 Homeobox_antennapedia
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain

    Graphical View of Domain Structure for InterPro Entry Q00056

    ProtoNet protein and cluster: Q00056

    1 Blocks protein domain: IPB001827 Homeobox protein

    UniProtKB/Swiss-Prot: HXA4_HUMAN, Q00056
    Similarity: Belongs to the Antp homeobox family. Deformed subfamily
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXA4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXA4_HUMAN, Q00056
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking
    sequence of its coding region with various affinities. The consensus sequences of the high and low affinity
    binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'

         Genatlas biochemistry entry for HOXA4:
    homeo box A4(1D),homologous to mouse Hox-1.4,Drosophila Dfd

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXA4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXA4:
     Increased S DNA content 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Hoxa4):
     behavior/neurological  mortality/aging  nervous system  skeleton 

    HOXA4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXA4: Hoxa4tm1Bhr Hoxa4tm1Mrc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOXA4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOXA4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXA4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXA4 

    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA4:
    hsa-miR-22 hsa-miR-582-5p hsa-miR-1294 hsa-miR-934 hsa-miR-558 hsa-miR-556-5p hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidHOXA4 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of HOXA4 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXA4

    1 Interacting protein for HOXA4 (Q000563) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFE2Q166213I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development ----
    GO:0009653anatomical structure morphogenesis TAS1675427
    GO:0009952anterior/posterior pattern specification IEA--

    HOXA4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXA4 (HXA4)

    Search CenterWatch for drugs/clinical trials and news about HOXA4 / HXA4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOXA4 gene: 
    NM_002141.4  

    Unigene Cluster for HOXA4:

    Homeobox A4
    Hs.533357  [show with all ESTs]
    Unigene Representative Sequence: NM_002141
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360046(uc003sym.4) ENST00000511914 ENST00000428284
    miRNA
    Products:
         
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA4:
    hsa-miR-22 hsa-miR-582-5p hsa-miR-1294 hsa-miR-934 hsa-miR-558 hsa-miR-556-5p hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidHOXA4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HOXA4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXA4
    Clone
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    GenScript: all cDNA clones in your preferred vector: HOXA4 (NM_002141)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXA4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA4
    Sirion Biotech Customized lentivirus for stable overexpression of HOXA4 
                         Customized lentivirus expression plasmids for stable overexpression of HOXA4 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXA4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXA4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXA4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXA4

    Additional mRNA sequence: 

    BC126993.1 BC126994.1 M74297.1 

    4 DOTS entries:

    DT.99946118  DT.121115460  DT.86851017  DT.40285593 

    24/81 AceView cDNA sequences (see all 81):

    AW015589 AA947856 AA534436 AW166311 NM_030661 AI627633 AI831660 NM_153631 
    AW849525 BM824037 NM_153632 BF435327 BF593069 BP872792 W69170 BX101261 
    AA449704 AI478474 BF431672 BF939880 AA909065 AA580334 T81791 BM984673 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXA4 expression in normal human tissues (normalized intensities)      HOXA4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTAAGAAT
    HOXA4 Expression
    About this image


    HOXA4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Epidermis (Integumentary System)    fully expand to see all 3 entries
             Intermediate Keratinocytes Embryonic Epidermis
     
     Somite (Muscoskeletal System)    fully expand to see all 2 entries
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
             Thoracic Mesenchymal Sclerotome
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Spinal Ventral Columns
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Cervical Sclerotome Cells Cervical Mesenchymal Sclerotome

    See HOXA4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXA4

    SOURCE GeneReport for Unigene cluster: Hs.533357

    UniProtKB/Swiss-Prot: HXA4_HUMAN, Q00056
    Tissue specificity: Embryonic nervous system

        SABiosciences Custom PCR Arrays for HOXA4
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOXA4 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxa41 , 5 homeobox A41, 5 84.21(n)1
    80(a)1
      6 (25.40 cM)5
    154011  NM_008265.31  NP_032291.11 
     521896715 
    chicken
    (Gallus gallus)
    Aves HOXA46
    HOXA46
    Homeobox protein Hox-A4
    57(a)
    57(a)
    1 ↔ many
    1 ↔ many
    2(32823690-32938755)
    2(32824509-32825927)
    lizard
    (Anolis carolinensis)
    Reptilia HOXA46
    Uncharacterized protein
    49(a)
    1 ↔ 1
    GL343275.1(1489989-1492053)
    zebrafish
    (Danio rerio)
    Actinopterygii hoxa4a6
    hoxc3a6
    homeo box C3a
    47(a)
    22(a)
    1 ↔ 1
    possible ortholog
    19(19233312-19235118)
    23(36158334-36200915)
    fruit fly
    (Drosophila melanogaster)
    Insecta Dfd3 induction of apoptosis transcription
    factor
    73(a)
    (best of 2)
      3 84A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea mab-56
    egl-56
    Homeobox protein egl-5
    29(a)
    15(a)
    many ↔ many
    many ↔ many
    III(7776907-7783454)
    III(7814382-7816451)


    ENSEMBL Gene Tree for HOXA4 (if available)
    TreeFam Gene Tree for HOXA4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXA4 gene
    GSX12  HOXA72  HOXA12  HOXB32  HOXD12  HOXA22  HOXB52  HOXC62  
    HOXC52  GSX22  HOXB42  HOXA52  HOXD32  HOXA62  HOXC82  HOXA32  
    HOXD82  HOXB62  HOXB12  HOXB82  HOXD42  HOXB22  PDX12  HOXB72  
    HOXC42  
    18/58 SIMAP similar genes for HOXA4 using alignment to 3 protein entries:     HXA4_HUMAN (see all proteins) (see all similar genes):
    HOX B6    HOXA6    HOXB6    HOXC6    HOXB8    MNX1
    HOXB4    BARX2    HOXD12    HOXA5    HOXC13    MEOX2
    HOXA11    BARX1    HOXA10    HOXD8    HOXA7    HOXB7

    HOXA4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/81 SNPs in HOXA4 are shown (see all 81)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362664
    A breast cancer sample4--see VAR_0362662 G D mis40--------
    rs47226621,2
    C,F,A,H--27168719(+) CTTTTT/CACCAA 1 -- ut31 ese312Minor allele frequency- C:0.04EA NS NA WA 668
    rs1112568301,2
    F--27168723(+) TCACCG/AATTTG 1 -- ut311Minor allele frequency- A:0.00CSA 1
    rs1880974111,2
    --27168744(+) GGTGTC/TTATTA 1 -- ut310--------
    rs1479235651,2
    C--27168848(+) ATTATA/GTGGAG 2 T I mis10--------
    rs175007571,2,4
    C,H--27168858(+) GGAGGG/AAACGG 2 /P /S mis1 ese3 trp36Minor allele frequency- A:0.00NS EA NA 392
    rs2016597671,2
    C--27168882(+) CGGGTC/G/TGGGGT 3 N H D mis11EU 587
    rs1398084841,2
    C--27168896(+) GATGGA/CGGTGT 2 R L mis11Minor allele frequency- C:0.00NA 4550
    rs2007256701,2
    --27168927(+) CCCTGG/TTGGGC 2 T P mis10--------
    rs1998976901,2
    C--27168938(+) CGGCAC/GAGGCC 2 S C mis10--------

    HapMap Linkage Disequilibrium report for HOXA4 (27168126 - 27170418 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for HOXA4 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv887856CNV Loss21882294
    nsv887876CNV Loss21882294
    nsv5674CNV Loss18451855
    dgv7233n71CNV Loss21882294
    dgv7231n71CNV Loss21882294
    dgv7235n71CNV Loss21882294
    dgv7236n71CNV Loss21882294
    dgv7234n71CNV Loss21882294
    dgv7232n71CNV Loss21882294
    nsv824042CNV Gain20364138


    Human Gene Mutation Database (HGMD): HOXA4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 142953    OMIM disorders: --

    12 diseases for HOXA4:    About MalaCards
    megacolon    abdominal aortic aneurysm    hypospadias    hirschsprung's disease
    aortic aneurysm    teratocarcinoma    acute myeloid leukemia    neuroblastoma
    myeloid leukemia    ovarian cancer    leukemia    pancreatitis


    HOXA4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HOXA4
    Human Genome Epidemiology (HuGE) Navigator: HOXA4 (3 documents)

    Export disorders for HOXA4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXA4 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with HOXA4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    2. Mutation screening of BMP4, BMP7, HOXA4 and HOXB6 genes in Chinese patients with hypospadias. (PubMed id 17003840)1, 4 Chen T....Shen Y. (2007)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    5. Alteration of homeobox gene expression by N-ras transformation of PA- 1 human teratocarcinoma cells. (PubMed id 1675427)1, 2 Buettner R.... Tainsky M.A. (1991)
    6. Expression of HOX homeogenes in human neuroblastoma cell culture lines. (PubMed id 1981366)1, 2 Peverali F.A.... Boncinelli E. (1990)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    8. Organization of human class I homeobox genes. (PubMed id 2576652)1, 2 Boncinelli E.... Simeone A. (1989)
    9. Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox. (PubMed id 2571574)1, 2 Ferguson-Smith A.C.... Ruddle F.H. (1989)
    10. HOXA4 gene promoter hypermethylation as an epigenetic mechanism mediating resistance to imatinib mesylate in chronic myeloid leukemia patients. (PubMed id 23484077)1 Elias M.H....Ankathil R. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3201 HGNC: 5105 AceView: HOXA4andHOXA3 Ensembl:ENSG00000197576 euGenes: HUgn3201
    ECgene: HOXA4 H-InvDB: HOXA4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXA4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOXA4 gene:
    Search GeneIP for patents involving HOXA4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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