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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXA3 Gene

protein-coding   GIFtS: 51
GCID: GC07M027113

homeobox A3

(Previous name: homeo box A3 )
(Previous symbols: HOX1E, HOX1)
 Explore 6 diseases affiliated with
HOXA3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXA3    

Aliases
for HOXA3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox A31 2     Homeobox Protein Hox-1E2 3
HOX1E1 2 3 5     Homeo Box 1E2
HOX11 2     Homeobox Protein Hox-A32
Homeo Box A31 2     Hox-1.5-Like Protein2

External Ids:    HGNC: 51041   Entrez Gene: 32002   Ensembl: ENSG000001059977   OMIM: 1429545   UniProtKB: O433653   

Export aliases for HOXA3 gene to outside databases

Previous GC identifers: GC07M026788 GC07M026888 GC07M026919 GC07M027026


Summaries
for HOXA3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXA3:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named
A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during
embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription
factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two
different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HXA3_HUMAN, O43365
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA3


Genomic Views
for HOXA3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXA3 gene promoter:
         Sp1   AP-2beta   HNF-4alpha2   AP-2gamma   AP-2alpha   HNF-4alpha1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): HOXA3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXA3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027113:  view genomic region     (about GC identifiers)

Start:
 27,145,809 bp from pter      End:
 27,192,200 bp from pter
Size:
 46,392 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,196,962-27,217,794     

Proteins
for HOXA3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXA3_HUMAN, O43365 (See protein sequence)
Recommended Name: Homeobox protein Hox-A3  
Size: 443 amino acids; 46369 Da
Subcellular location: Nucleus
Secondary accessions: A4D181

Explore the universe of human proteins at neXtProt for HOXA3: NX_O43365

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43365

    • HOXA3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_109377.1  NP_705895.1  

    ENSEMBL proteins: 
     ENSP00000379640   ENSP00000324884   ENSP00000429426   ENSP00000430566   ENSP00000430111  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 3): HOXA3
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    Novus Biologicals HOXA3 Protein
    Novus Biologicals HOXA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOXA3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    HOXA3 for ontologies           About GeneDecksing



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    Uscn Antibodies for HOXA3
    ThermoFisher Antibody for HOXA3

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    Uscn ELISAs and CLIAs for HOXA3

    Protein Domains /
    Families
    for HOXA3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXA3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O43365

    ProtoNet protein and cluster: O43365

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXA3_HUMAN, O43365
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXA3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXA3_HUMAN, O43365
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXA3:
    homeo box A3(1E),homologous to mouse Hox-1.5,Drosophila Zen1,Zen2

    10/316 SABiosciences Target genes for HOXA3 (see all 316):
    A2ML1 ABCG8 ACN9 ADAM17 ADAM32 AKR1D1 ALG11 ALG8 ALPK1 ANKFY1

    miRNA
    Products:            		miRTarBase miRNAs that target HOXA3:
    hsa-mir-210 (MIRT003164)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXA3
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA3 (see all 68):
    hsa-miR-607 hsa-miR-15a hsa-miR-4272 hsa-miR-519a hsa-miR-376a* hsa-miR-3613-3p hsa-miR-130b hsa-miR-105*
    SwitchGear 3'UTR luciferase reporter plasmid: HOXA3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXA3 (see all 4)
    OriGene shRNA RFP: HOXA3
    OriGene siRNA: HOXA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXA3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HOXA3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA3 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HOXA3 (NM_030661)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA3 

    Cell Line
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    Search LifeMap BioReagents cell lines for HOXA3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA3

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0071837HMG box domain binding IEA--


    HOXA3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for HOXA3: Hoxa3tm1Kth Hoxa3tm1Mrc
         14 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Hoxa3):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size  hematopoietic system  immune system  mortality/aging 
     muscle  nervous system  respiratory system  skeleton 

    HOXA3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXA3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOXA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for HOXA3 (O433653 ENSP000003248844) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
    PWP1Q136103, ENSP000002585314I2D: score=1 STRING: ENSP00000258531
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    SEC23BQ154373I2D: score=1 
    E2F4ENSP000003686864STRING: ENSP00000368686
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEP17972163
    GO:0001974blood vessel remodeling IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0008284positive regulation of cell proliferation IEA--
    GO:0009887organ morphogenesis ----


    HOXA3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXA3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXA3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXA3
    1 Novoseek chemical compound relationship for HOXA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 41 5 12756180 (2), 9894676 (2)

    Search CenterWatch for drugs/clinical trials and news about HOXA3 / HXA3 

    Transcripts
    for HOXA3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXA3 gene (3 alternative transcripts): 
    NM_030661.4  NM_153631.2  NM_153632.2  

    Unigene Cluster for HOXA3:

    Homeobox A3
    Hs.659337  [show with all ESTs]
    Unigene Representative Sequence: NM_153631
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396352(uc011jzl.2 uc003syk.3) ENST00000317201 ENST00000522788
    ENST00000522456 ENST00000521779 ENST00000521401 ENST00000518451 ENST00000467897


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXA3
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA3 (see all 68):
    hsa-miR-607 hsa-miR-15a hsa-miR-4272 hsa-miR-519a hsa-miR-376a* hsa-miR-3613-3p hsa-miR-130b hsa-miR-105*
    SwitchGear 3'UTR luciferase reporter plasmid: HOXA3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXA3 (see all 4)
    OriGene shRNA RFP: HOXA3
    OriGene siRNA: HOXA3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXA3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA3 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA3 (see all 3)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): HOXA3 (NM_030661)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOXA3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXA3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXA3

    Additional cDNA sequence: 

    AK056567.1 AK094200.1 BC015180.1 

    8 DOTS entries:

    DT.40232900  DT.87046691  DT.121115437  DT.121115457  DT.121115459  DT.97777553  DT.100884355  DT.121115444 

    24/81 AceView cDNA sequences (see all 81):

    AA947856 BF435327 AW166311 NM_030661 BM824037 BF593069 AA534436 AW015589 
    AW849525 AI831660 AI627633 NM_153631 NM_153632 AK094200 BM984673 AI934335 
    AI660911 BM984688 CF541295 M74297 BF939880 AA863038 BG413439 AI768663 

    GeneLoc Exon Structure


    Expression
    for HOXA3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXA3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartCardinal VeinsVenous Endothelial CellsEndothelium
    Head MesenchymeBranchial Arch 3,4,6Cardiac Neural Crest CellsNeural Crest
    Lateral Plate MesodermEmbryonic Capillary PlexusAngioblastsEndothelium
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    Posterior foregut-like cells (A scalable, suspensi...)
    Beating cell clusters (Spontaneous differen...)

    See HOXA3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXA3

    SOURCE GeneReport for Unigene cluster: Hs.659337
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXA3: 
              Stem Cell Transcription Factors in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOXA3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA3

    Orthologs
    for HOXA3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for HOXA3 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXA36
    		 homeobox A3
    		 81(a)
    		 1 ↔ 1
    		 2(32524754-32527430)
    lizard
    (Anolis carolinensis)    		 Reptilia HOXA36
    		 --
    		 70(a)
    		 1 ↔ 1
    		 GL343275.1(1519433-1524136)
    African clawed frog
    (Xenopus laevis)    		 Amphibia hoxa3a-prov2 homeo box A3 75.8(n)    BC041731.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxa3a6
    hoxc3a6
    		 homeo box C3a
    		 61(a)
    25(a)
    		 1 ↔ 1
    possible ortholog
    		 19(19220695-19245990)
    23(36158334-36200915)


    ENSEMBL Gene Tree for HOXA3 (if available)
    TreeFam Gene Tree for HOXA3 (if available) 

    Paralogs
    for HOXA3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXA3 gene
    GSX12  HOXA72  HOXA12  HOXD12  HOXA22  HOXB32  HOXC62  HOXB52  
    GSX22  HOXC52  HOXB42  HOXA52  HOXA42  HOXD32  HOXC82  HOXA62  
    HOXD82  HOXB12  HOXB62  HOXB82  HOXD42  HOXB22  HOXB72  PDX12  
    HOXC42  
    5 SIMAP similar genes for HOXA3 using alignment to 5 protein entries:     HXA3_HUMAN (see all proteins):
    HOXD8    HOXB3    HLX    HOXD3    HOXD4

    HOXA3 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXA3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/402 NCBI SNPs in HOXA3 are shown (see all 402)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs115640551,2
    		C,F,H,--27145350(+) AAACCA/GTGAGG 2 -- ds500112Minor allele frequency- G:0.18EA NS WA NA 1364
    rs1816429191,2
    		--27145380(+) CGTTGA/GGACCC 2 -- ds50010--------
    rs1876613581,2
    		--27145412(+) CCAGTA/GCCTGC 2 -- ds50010--------
    rs24284331,2
    		C,F,A,H,--27145517(+) TTCTGT/CCTCTG 2 -- ds50019Minor allele frequency- C:0.18EA NS WA NA 948
    rs789229341,2
    		C,--27145549(+) TAGGG-/ATTT  
                ATTTC     		2 -- ds50010--------
    rs283571361,2
    		H--27145553(+) GATTTA/TTTTCT 2 -- ds50014Minor allele frequency- T:0.00NS EA 408
    rs283571371,2
    		H--27145576(+) TCCTGA/GTCCCC 2 -- ds50014Minor allele frequency- G:0.00NS EA 404
    rs286499301,2
    		C,--27145578(+) CTGATA/CCCCAG 2 -- ds50011Minor allele frequency- C:0.00WA 2
    rs1147351191,2
    		F,--27145619(+) AGGGGG/TTGATG 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs24652761,2
    		C,F,H,--27145717(+) TTACTG/ATGCCT 2 -- ds500119Minor allele frequency- A:0.17EA NS NA WA 2514

    HapMap Linkage Disequilibrium report for HOXA3 (27145809 - 27192200 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HOXA3: --

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    Disorders / Diseases
    for HOXA3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXA3 for disorders           About GeneDecksing

    OMIM gene information: 142954    OMIM disorders: --

    6 diseases for HOXA3:    About MalaCards
    vacterl association    esophageal atresia    teratocarcinoma    pharyngitis
    esophagitis    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for HOXA3:
    VACTERL association     Esophageal atresia
    Human Genome Epidemiology (HuGE) Navigator: HOXA3 (2 documents)

    Export disorders for HOXA3 gene to outside databases

    Publications
    for HOXA3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXA3 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with HOXA3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    4. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    5. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    6. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. (PubMed id 9520319)1, 9 Manley N.R. and Capecchi M.R. (1998)
    7. Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1. (PubMed id 9894676)1, 9 Mulder G.B....Maggio-Price L. (1998)
    8. Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. (PubMed id 11823429)1, 9 Manzanares M....Charnay P. (2002)
    9. Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
    10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)

    External Searches for HOXA3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOXA3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3200 HGNC: 5104 AceView: HOXA4andHOXA3 Ensembl:ENSG00000105997 euGenes: HUgn3200
    ECgene: HOXA3 H-InvDB: HOXA3

    Other Databases showing HOXA3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXA3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXA3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOXA3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXA3 gene:
    Search GeneIP for patents involving HOXA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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