Aliases for HOXA3 Gene
Aliases for HOXA3 Gene
External Ids for HOXA3 Gene
- HGNC: 5104
- Entrez Gene: 3200
- Ensembl: ENSG00000105997
- OMIM: 142954
- UniProtKB: O43365
Previous HGNC Symbols for HOXA3 Gene
- HOX1E
- HOX1
Previous GeneCards Identifiers for HOXA3 Gene
- GC07M026788
- GC07M026888
- GC07M026919
- GC07M027113
- GC07M027026
Summaries for HOXA3 Gene
-
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA3 Gene
HOXA3 (Homeobox A3) is a Protein Coding gene. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and HMG box domain binding. An important paralog of this gene is HOXB3.
UniProtKB/Swiss-Prot for HOXA3 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA3 Gene
Genomics for HOXA3 Gene
Regulatory Elements for HOXA3 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|---|---|---|
| ENSR00000209843 | 81 | 201 | PKNOX1 SUZ12 KLF17 CTBP1 POLR2A ZNF391 EZH2 ZBTB10 ZNF362 RNF2 |
| ENSR00000325320 | 681 | 201 | ZSCAN4 KLF17 FEZF1 GLI4 GLIS2 ZNF366 KLF7 ZNF488 ZEB2 ZNF398 |
| ENSR00000325319 | 1681 | 601 | PKNOX1 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ZHX2 REST SMARCB1 ZNF623 |
- Transcription factor binding sites by QIAGEN in the HOXA3 gene promoter:
Regulatory Element Products
Genomic Location for HOXA3 Gene
- Chromosome:
- 7
- Start:
- 27,106,184 bp from pter
- End:
- 27,152,581 bp from pter
- Size:
- 46,398 bases
- Orientation:
- Minus strand
Genomic View for HOXA3 Gene
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXA3 Gene
Proteins for HOXA3 Gene
-
Protein details for HOXA3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43365-HXA3_HUMAN
- Recommended name:
- Homeobox protein Hox-A3
- Protein Accession:
- O43365
- A4D181
Protein attributes for HOXA3 Gene
- Size:
- 443 amino acids
- Molecular mass:
- 46369 Da
- Quaternary structure:
- No Data Available
Protein Expression for HOXA3 Gene
Post-translational modifications for HOXA3 Gene
Other Protein References for HOXA3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOXA3
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- Invitrogen Antibodies for HOXA3
- antibodies-online Antibodies for HOXA3: See all 72
- GeneTex HOXA3 antibody for HOXA3
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXA3
Protein Products
-
OriGene Purified Proteins for HOXA3
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- antibodies-online Proteins for HOXA3: See all 6
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Assay Products
No data available for DME Specific Peptides for HOXA3 Gene
Domains & Families for HOXA3 Gene
Gene Families for HOXA3 Gene
Protein Domains for HOXA3 Gene
Suggested Antigen Peptide Sequences for HOXA3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43365- Family:
-
- Belongs to the Antp homeobox family.
Function for HOXA3 Gene
Molecular function for HOXA3 Gene
- GENATLAS Biochemistry:
- homeo box A3(1E),homologous to mouse Hox-1.5,Drosophila Zen1,Zen2
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 21516116 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
| GO:0071837 | HMG box domain binding | IEA | -- |
Phenotypes for HOXA3 Gene
- MGI mutant phenotypes for HOXA3:
-
inferred from 8 alleles
- mortality/aging
- cellular phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- cardiovascular system phenotype
- respiratory system phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for HOXA3:
Animal Model Products
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-
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CRISPR Products
-
OriGene CRISPR knockouts for HOXA3
-
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miRNA for HOXA3 Gene
- miRTarBase miRNAs that target HOXA3
-
- hsa-mir-210-3p (MIRT003164)
- hsa-mir-151a-5p (MIRT019529)
- hsa-mir-124-3p (MIRT022611)
- hsa-mir-7-5p (MIRT025796)
- hsa-mir-103a-3p (MIRT027069)
- hsa-mir-16-5p (MIRT031721)
- hsa-mir-1296-5p (MIRT036095)
- hsa-mir-99b-5p (MIRT044187)
- hsa-mir-10a-5p (MIRT047615)
- hsa-mir-8066 (MIRT103494)
- hsa-mir-4468 (MIRT475528)
- hsa-mir-3185 (MIRT475529)
- hsa-mir-4680-5p (MIRT475530)
- hsa-mir-6830-5p (MIRT475531)
- hsa-mir-4330 (MIRT475532)
- hsa-mir-4511 (MIRT475533)
- hsa-mir-6838-5p (MIRT475534)
- hsa-mir-424-5p (MIRT475535)
- hsa-mir-195-5p (MIRT475536)
- hsa-mir-497-5p (MIRT475537)
- hsa-mir-15b-5p (MIRT475538)
- hsa-mir-15a-5p (MIRT475539)
- hsa-mir-4531 (MIRT557100)
- hsa-mir-3192-3p (MIRT557101)
- hsa-mir-4726-5p (MIRT557102)
- hsa-mir-4640-5p (MIRT557103)
- hsa-mir-4516 (MIRT557104)
- hsa-mir-5703 (MIRT557105)
- hsa-mir-4434 (MIRT557106)
- hsa-mir-6722-3p (MIRT557107)
- hsa-mir-1909-3p (MIRT557108)
- hsa-mir-6836-5p (MIRT557109)
- hsa-mir-6132 (MIRT557110)
- hsa-mir-6770-5p (MIRT557111)
- hsa-mir-3151-3p (MIRT557112)
- hsa-mir-3918 (MIRT557113)
- hsa-mir-6895-5p (MIRT557114)
- hsa-mir-570-5p (MIRT557115)
- hsa-mir-548ba (MIRT557116)
- hsa-mir-548ai (MIRT557117)
- hsa-mir-548ag (MIRT557118)
- hsa-mir-6081 (MIRT557119)
- hsa-mir-6077 (MIRT557120)
- hsa-mir-873-5p (MIRT557121)
- hsa-mir-151b (MIRT557122)
- hsa-mir-611 (MIRT557123)
- hsa-mir-3131 (MIRT557124)
- hsa-mir-3677-5p (MIRT557125)
- hsa-mir-6165 (MIRT557126)
- hsa-mir-577 (MIRT557127)
- hsa-mir-6856-3p (MIRT557128)
Transcription Factor Targets for HOXA3 Gene
miRNA Products
- Search ViGene Biosciences for HOXA3
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HOXA3
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Clone Products
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Cell Line Products
-
Horizon Cell Lines for HOXA3
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HOXA3 Gene
Localization for HOXA3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXA3 Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for HOXA3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for HOXA3 Gene
Interacting Proteins for HOXA3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001525 | angiogenesis | IEP | 17972163 |
| GO:0001974 | blood vessel remodeling | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for SIGNOR curated interactions for HOXA3 Gene
Transcripts for HOXA3 Gene
mRNA/cDNA for HOXA3 Gene
- (8) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (81) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXA3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA3
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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Flow Cytometry Products
Expression for HOXA3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Endothelium (Cardiovascular System)
-
Head Mesenchyme (Muscoskeletal System)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
- Branchial Arch 1
-
Heart (Cardiovascular System)
- Endocardial Tube Cells Endocardium
- Venous Endothelial Cells Cardinal Veins
- NULL (Uncategorized)
-
Neural Crest (Gastrulation Derivatives)
- Cardiac Neural Crest Cells Branchial Arch 3,4,6
- Neural Tube (Nervous System)
- Bone (Muscoskeletal System)
- Dermis (Integumentary System)
- Fibroblasts
- Astrocytes (Nervous System)
- Brain (Nervous System)
- Glial Cells
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for HOXA3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXA3 Gene:
HOXA3SOURCE GeneReport for Unigene cluster for HOXA3 Gene:
Hs.659337Primer Products
-
OriGene qPCR primer pairs for HOXA3
-
OriGene qPCR primer pairs and template standards for HOXA3
No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA3 Gene
Orthologs for HOXA3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXA3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXA3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxa3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxa3 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXA3 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXA3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXA3 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXA3 35 35 |
|
OneToMany | |
| LOC100858480 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | HOXA3 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxa3 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | hoxa3a-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxa3a 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXA3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXA3 Gene
Paralogs for HOXA3 Gene
(5) SIMAP similar genes for HOXA3 Gene using alignment to 5 proteins:
Variants for HOXA3 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs764656757 | A breast cancer sample | 27,110,517(+) | GCCGT(A/C/T)GGCGC | reference, missense | |
| VAR_036265 | A breast cancer sample | ||||
| rs1000045615 | -- | 27,113,619(+) | GCCCT(C/G)CTTAC | intron-variant | |
| rs1000079925 | -- | 27,150,131(+) | GGCTA(C/G)TGCAT | intron-variant | |
| rs1000231152 | -- | 27,116,735(+) | AAATG(C/T)GCCAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1094n67 | CNV | gain | 20364138 |
| dgv11244n54 | CNV | loss | 21841781 |
| esv3444885 | CNV | insertion | 20981092 |
| esv3612654 | CNV | loss | 21293372 |
| nsv1076881 | CNV | deletion | 25765185 |
| nsv1126777 | CNV | deletion | 24896259 |
| nsv5674 | CNV | deletion | 18451855 |
| nsv606464 | CNV | loss | 21841781 |
| nsv606465 | CNV | loss | 21841781 |
| nsv7393 | OTHER | inversion | 18451855 |
Relevant External Links for HOXA3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOXA3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA3 Gene
Disorders for HOXA3 Gene
Relevant External Links for HOXA3
No disorders were found for HOXA3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXA3 Gene
Publications for HOXA3 Gene
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4 64
- The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
- Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. (PMID: 11823429) Manzanares M. … Charnay P. (EMBO J. 2002) 3 22 64
Products for HOXA3 Gene
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- Yeast expression
Sources for HOXA3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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