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HOXA3 Gene

protein-coding   GIFtS: 52
GCID: GC07M027113

Homeobox A3

(Previous name: homeo box A3)
(Previous symbols: HOX1E, HOX1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox A31 2     Homeobox Protein Hox-1E2 3
HOX1E1 2 3 5     Homeo Box 1E2
HOX11 2     Homeobox Protein Hox-A32
Homeo Box A31 2     Hox-1.5-Like Protein2

External Ids:    HGNC: 51041   Entrez Gene: 32002   Ensembl: ENSG000001059977   OMIM: 1429545   UniProtKB: O433653   

Export aliases for HOXA3 gene to outside databases

Previous GC identifers: GC07M026788 GC07M026888 GC07M026919 GC07M027026


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXA3 Gene:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters
named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally
regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a
DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three
transcript variants encoding two different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXA3 Gene:
HOXA3 (homeobox A3) is a protein-coding gene. Diseases associated with HOXA3 include vacterl association, and esophageal atresia. GO annotations related to this gene include HMG box domain binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is GSX1.

UniProtKB/Swiss-Prot: HXA3_HUMAN, O43365
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXA3 gene promoter:
         Sp1   AP-2beta   HNF-4alpha2   AP-2gamma   AP-2alpha   HNF-4alpha1   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 5): HOXA3 promoter sequence
   Search Chromatin IP Primers for HOXA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA3 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027113:  view genomic region     (about GC identifiers)

Start:
27,145,803 bp from pter      End:
27,192,200 bp from pter
Size:
46,398 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,196,962-27,217,794     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HXA3_HUMAN, O43365 (See protein sequence)
Recommended Name: Homeobox protein Hox-A3  
Size: 443 amino acids; 46369 Da
Secondary accessions: A4D181

Explore the universe of human proteins at neXtProt for HOXA3: NX_O43365

Explore proteomics data for HOXA3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_109377.1  NP_705895.1  

    ENSEMBL proteins: 
     ENSP00000379640   ENSP00000324884   ENSP00000429426   ENSP00000430566   ENSP00000430111  

    HOXA3 Human Recombinant Protein Products:

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    Novus Biologicals HOXA3 Protein
    Novus Biologicals HOXA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for HOXA3

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    Abcam antibodies for HOXA3
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    ThermoFisher Antibody for HOXA3
    LSBio Antibodies in human, mouse, rat for HOXA3

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    Cloud-Clone Corp. ELISAs for HOXA3
    Cloud-Clone Corp. CLIAs for HOXA3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    Selected InterPro protein domains (see all 6):
     IPR001827 Homeobox_Antennapedia_CS
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O43365

    ProtoNet protein and cluster: O43365

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB001827 Homeobox protein


    UniProtKB/Swiss-Prot: HXA3_HUMAN, O43365
    Similarity: Belongs to the Antp homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXA3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXA3_HUMAN, O43365
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXA3:
    homeo box A3(1E),homologous to mouse Hox-1.5,Drosophila Zen1,Zen2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0071837HMG box domain binding IEA--
         
    HOXA3 for ontologies           About GeneDecksing


    Phenotypes:
         14 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Hoxa3):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  immune system  mortality/aging 
     muscle  nervous system  respiratory system  skeleton 

    HOXA3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXA3: Hoxa3tm1Kth Hoxa3tm1Mrc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXA3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXA3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXA3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXA3:
    hsa-mir-1296-5p (MIRT036095), hsa-mir-10a-5p (MIRT047615), hsa-mir-210-3p (MIRT003164), hsa-mir-151a-5p (MIRT019529), hsa-mir-16-5p (MIRT031721), hsa-mir-99b-5p (MIRT044187), hsa-mir-124-3p (MIRT022611), hsa-mir-103a-3p (MIRT027069), hsa-mir-7-5p (MIRT025796)

    Block miRNA regulation of human, mouse, rat HOXA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXA3 (see all 68):
    hsa-miR-607 hsa-miR-15a hsa-miR-4272 hsa-miR-519a hsa-miR-376a* hsa-miR-3613-3p hsa-miR-130b hsa-miR-105*
    SwitchGear 3'UTR luciferase reporter plasmidHOXA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXA3
    Predesigned siRNA for gene silencing in human, mouse, rat HOXA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HOXA3

    Clone
    Products:
         
    OriGene clones in human, mouse for HOXA3 (see all 13)
    OriGene ORF clones in mouse, rat for HOXA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HOXA3 (NM_030661)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for HOXA3
    Browse ESI BIO Cell Lines and PureStem Progenitors for HOXA3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXA3_HUMAN, O43365: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    HOXA3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXA3: 
              Stem Cell Transcription Factors in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for HOXA3 (O433653 ENSP000003248844) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
    SOX10P566933, ENSP000003541304I2D: score=1 STRING: ENSP00000354130
    PWP1Q136103I2D: score=1 
    SEC23BQ154373I2D: score=1 
    E2F4ENSP000003686864STRING: ENSP00000368686
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEP17972163
    GO:0001974blood vessel remodeling IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0008284positive regulation of cell proliferation IEA--

    HOXA3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXA3 (HXA3)

    1 Novoseek inferred chemical compound relationship for HOXA3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 41 5 12756180 (2), 9894676 (2)



    HOXA3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOXA3 gene (3 alternative transcripts): 
    NM_030661.4  NM_153631.2  NM_153632.2  

    Unigene Cluster for HOXA3:

    Homeobox A3
    Hs.659337  [show with all ESTs]
    Unigene Representative Sequence: NM_153631
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396352(uc011jzl.2 uc003syk.3) ENST00000317201 ENST00000522788
    ENST00000522456 ENST00000521779 ENST00000521401 ENST00000518451
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat HOXA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXA3 (see all 68):
    hsa-miR-607 hsa-miR-15a hsa-miR-4272 hsa-miR-519a hsa-miR-376a* hsa-miR-3613-3p hsa-miR-130b hsa-miR-105*
    SwitchGear 3'UTR luciferase reporter plasmidHOXA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for HOXA3
    Predesigned siRNA for gene silencing in human, mouse, rat HOXA3
    Clone
    Products:
         
    OriGene clones in human, mouse for HOXA3 (see all 13)
    OriGene ORF clones in mouse, rat for HOXA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HOXA3 (NM_030661)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HOXA3
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXA3
      QuantiTect SYBR Green Assays in human, mouse, rat HOXA3
      QuantiFast Probe-based Assays in human, mouse, rat HOXA3

    Additional mRNA sequence: 

    AK056567.1 AK094200.1 BC015180.1 

    8 DOTS entries:

    DT.40232900  DT.87046691  DT.121115437  DT.121115457  DT.121115459  DT.97777553  DT.100884355  DT.121115444 

    Selected AceView cDNA sequences (see all 81):

    AW849525 AW015589 NM_030661 NM_153632 AI831660 BF593069 BM824037 AA947856 
    AI627633 AW166311 BF435327 AA534436 NM_153631 BF939880 AA580334 AI478474 
    BC015180 AA449704 BU634313 BE314975 BF431672 W69170 AI206422 CF541295 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXA3 expression in normal human tissues (normalized intensities)      HOXA3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    HOXA3 Expression
    About this image


    HOXA3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Venous Endothelial Cells Cardinal Veins
             Human umbilical vein endothelial cells (HUVEC)
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Venous Endothelial Cells Cardinal Veins
     
     Head Mesenchyme (Muscoskeletal System)    fully expand to see all 2 entries
             Cardiac Neural Crest Cells Branchial Arch 3,4,6
             Branchial Arch 1
     
     Neural Crest (Gastrulation Derivatives)
             Cardiac Neural Crest Cells Branchial Arch 3,4,6
     
     NULL (Uncategorized)
             Neural rosettes
    HOXA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659337
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXA3: 
              Stem Cell Transcription Factors in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HOXA3
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXA3
    QuantiTect SYBR Green Assays in human, mouse, rat HOXA3
    QuantiFast Probe-based Assays in human, mouse, rat HOXA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HOXA3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxa31 , 5 homeobox A31, 5 88.84(n)1
    93.89(a)1
      6 (25.40 cM)5
    154001  NM_010452.31  NP_034582.11 
     521633595 
    chicken
    (Gallus gallus)
    Aves HOXA31 homeobox A3 76.27(n)
    81.11(a)
      395231  NM_204548.1  NP_989879.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXA36
    homeobox A3
    73(a)
    1 ↔ 1
    GL343275.1(1494486-1527894)
    African clawed frog
    (Xenopus laevis)
    Amphibia hoxa3a-prov2 homeo box A3 75.8(n)    BC041731.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxa3a1 homeo box A3a 63.43(n)
    64.19(a)
      58049  NM_131534.1  NP_571609.1 


    ENSEMBL Gene Tree for HOXA3 (if available)
    TreeFam Gene Tree for HOXA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXA3 gene
    GSX12  MEOX12  EVX22  HOXA12  HOXB12  HOXB32  HOXD12  HOXA22  
    GSX22  EVX12  HOXB22  MEOX22  PDX12  HOXD32  
    5 SIMAP similar genes for HOXA3 using alignment to 5 protein entries:     HXA3_HUMAN (see all proteins):
    HOXD8    HOXB3    HLX    HOXD3    HOXD4

    HOXA3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXA3 (see all 280)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362644
    A breast cancer sample4--see VAR_0362642 D N mis40--------
    VAR_0362654
    A breast cancer sample4--see VAR_0362652 A T mis40--------
    rs115640551,2
    C,F,H--27145350(+) AAACCA/GTGAGG 2 -- ds500112Minor allele frequency- G:0.18EA NS WA NA 1364
    rs1816429191,2
    --27145380(+) CGTTGA/GGACCC 2 -- ds50010--------
    rs1876613581,2
    --27145412(+) CCAGTA/GCCTGC 2 -- ds50010--------
    rs24284331,2
    C,F,A,H--27145517(+) TTCTGT/CCTCTG 2 -- ds50019Minor allele frequency- C:0.18EA NS WA NA 948
    rs789229341,2
    C--27145549(+) TAGGG-/ATTT  
            
    ATTTC
    2 -- ds50010--------
    rs283571361,2
    H--27145553(+) GATTTA/TTTTCT 2 -- ds50014Minor allele frequency- T:0.00NS EA 408
    rs283571371,2
    H--27145576(+) TCCTGA/GTCCCC 2 -- ds50014Minor allele frequency- G:0.00NS EA 404
    rs286499301,2
    C,F--27145578(+) CTGATA/CCCCAG 2 -- ds50011Minor allele frequency- C:0.00WA 2

    HapMap Linkage Disequilibrium report for HOXA3 (27145803 - 27192200 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for HOXA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887856CNV Loss21882294
    nsv5674CNV Loss18451855
    dgv7233n71CNV Loss21882294
    nsv887870CNV Loss21882294
    dgv7231n71CNV Loss21882294
    dgv7235n71CNV Loss21882294
    dgv7234n71CNV Loss21882294
    dgv7232n71CNV Loss21882294
    dgv1094n67CNV Gain20364138
    nsv7393OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142954    OMIM disorders: --

    9 diseases for HOXA3:    About MalaCards
    vacterl association    esophageal atresia    pharyngitis    teratocarcinoma
    breast and colorectal cancer    endotheliitis    esophagitis    thyroiditis
    colorectal cancer

    2 diseases from the University of Copenhagen DISEASES database for HOXA3:
    VACTERL association     Esophageal atresia

    HOXA3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HOXA3
    Human Genome Epidemiology (HuGE) Navigator: HOXA3 (2 documents)

    Export disorders for HOXA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXA3 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with HOXA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    6. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)
    7. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. (PubMed id 9520319)1, 9 Manley N.R. and Capecchi M.R. (Dev. Biol. 1998)
    8. Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1. (PubMed id 9894676)1, 9 Mulder G.B....Maggio-Price L. (Teratology 1998)
    9. Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain. (PubMed id 11823429)1, 9 Manzanares M....Charnay P. (EMBO J. 2002)
    10. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3200 HGNC: 5104 AceView: HOXA4andHOXA3 Ensembl:ENSG00000105997 euGenes: HUgn3200
    ECgene: HOXA3 H-InvDB: HOXA3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXA3 gene:
    Search GeneIP for patents involving HOXA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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