Aliases for HOXA13 Gene
Aliases for HOXA13 Gene
External Ids for HOXA13 Gene
- HGNC: 5102
- Entrez Gene: 3209
- Ensembl: ENSG00000106031
- OMIM: 142959
- UniProtKB: P31271
Previous HGNC Symbols for HOXA13 Gene
- HOX1J
- HOX1
Previous GeneCards Identifiers for HOXA13 Gene
- GC07M026880
- GC07M026944
- GC07M026978
- GC07M027009
- GC07M027203
- GC07M027235
- GC07M027246
- GC07M027256
- GC07M027194
Summaries for HOXA13 Gene
-
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA13 Gene
HOXA13 (Homeobox A13) is a Protein Coding gene. Diseases associated with HOXA13 include Hand-Foot-Uterus Syndrome and Guttmacher Syndrome. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is HOXC13.
UniProtKB/Swiss-Prot for HOXA13 Gene
-
Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA13 Gene
Genomics for HOXA13 Gene
Regulatory Elements for HOXA13 Gene
Enhancers for HOXA13 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXA13 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXA13 gene promoter:
Regulatory Element Products
Genomic Location for HOXA13 Gene
- Chromosome:
- 7
- Start:
- 27,193,419 bp from pter
- End:
- 27,200,266 bp from pter
- Size:
- 6,848 bases
- Orientation:
- Minus strand
Genomic View for HOXA13 Gene
Genes around HOXA13 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
HOXA13 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXA13 Gene
Proteins for HOXA13 Gene
-
Protein details for HOXA13 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31271-HXA13_HUMAN
- Recommended name:
- Homeobox protein Hox-A13
- Protein Accession:
- P31271
- A4D188
- O43371
Protein attributes for HOXA13 Gene
- Size:
- 388 amino acids
- Molecular mass:
- 39727 Da
- Quaternary structure:
-
- Binds DNA as a homodimer. Interacts with MEIS1, MEIS2 and MEIS3 (By similarity).
Protein Expression for HOXA13 Gene
Post-translational modifications for HOXA13 Gene
Other Protein References for HOXA13 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HOXA13
-
Custom Antibody ServicesOriGene Antibodies for HOXA13
- Novus Biologicals Antibodies for HOXA13
- Invitrogen Antibodies for HOXA13
- antibodies-online Antibodies for HOXA13: See all 40
- Search GeneTex for Antibodies for HOXA13
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HOXA13
- Origene Custom Protein Services for HOXA13
- Novus Biologicals proteins for HOXA13
- antibodies-online Proteins for HOXA13: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXA13
Assay Products
No data available for DME Specific Peptides for HOXA13 Gene
Domains & Families for HOXA13 Gene
Gene Families for HOXA13 Gene
Protein Domains for HOXA13 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXA13 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31271- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXA13 Gene
Molecular function for HOXA13 Gene
- GENATLAS Biochemistry:
- homeo box A13(1J),homologous to mouse Hox-1.10 (hypodactyly),expressed in the developing lower genitourinary tract (abnormal seminal vesicle and prostate development),altered in hypodactyly mutants
- UniProtKB/Swiss-Prot Function:
- Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | 9020844 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXA13 Gene
- MGI mutant phenotypes for HOXA13:
-
inferred from 7 alleles
- mortality/aging
- growth/size/body region phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- vision/eye phenotype
- integument phenotype
- limbs/digits/tail phenotype
- skeleton phenotype
- embryo phenotype
- renal/urinary system phenotype
- GenomeRNAi human phenotypes for HOXA13:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased IL-8 secretion
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
Animal Models for HOXA13 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA13 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA13 gene
- Search ViGene Biosciences for HOXA13
CRISPR Products
-
OriGene CRISPR knockouts for HOXA13
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA13
- GenScript: Design CRISPR guide RNA sequences for HOXA13
miRNA for HOXA13 Gene
- miRTarBase miRNAs that target HOXA13
-
- hsa-mir-142-3p (MIRT021544)
- hsa-mir-215-5p (MIRT024658)
- hsa-mir-192-5p (MIRT026124)
- hsa-mir-760 (MIRT036765)
- hsa-mir-125b-5p (MIRT045907)
- hsa-mir-222-3p (MIRT046676)
- hsa-mir-519d-5p (MIRT320503)
- hsa-mir-3611 (MIRT497028)
- hsa-mir-4252 (MIRT497029)
- hsa-mir-551b-5p (MIRT497030)
- hsa-mir-197-3p (MIRT532475)
- hsa-mir-6828-5p (MIRT532476)
- hsa-mir-4696 (MIRT532477)
- hsa-mir-6837-3p (MIRT532478)
- hsa-mir-6754-3p (MIRT532479)
- hsa-mir-412-3p (MIRT532480)
- hsa-mir-3922-5p (MIRT532481)
- hsa-mir-451b (MIRT532482)
- hsa-mir-6807-3p (MIRT532483)
- hsa-mir-217 (MIRT532484)
- hsa-mir-4643 (MIRT532485)
- hsa-mir-7109-5p (MIRT532486)
- hsa-mir-6885-5p (MIRT532487)
- hsa-mir-328-5p (MIRT532488)
- hsa-mir-6887-5p (MIRT532489)
- hsa-mir-6795-5p (MIRT532490)
- hsa-mir-625-5p (MIRT532491)
- hsa-mir-4668-5p (MIRT532492)
- hsa-mir-3148 (MIRT532493)
- hsa-mir-637 (MIRT532494)
- hsa-mir-4286 (MIRT532495)
- hsa-mir-5003-5p (MIRT532496)
- hsa-mir-3529-3p (MIRT532497)
- hsa-mir-6732-3p (MIRT532498)
- hsa-mir-4668-3p (MIRT532499)
- hsa-mir-605-5p (MIRT532500)
- hsa-mir-548c-3p (MIRT532501)
- hsa-mir-6738-3p (MIRT557129)
- hsa-mir-544a (MIRT557130)
- hsa-mir-374b-3p (MIRT557131)
- hsa-mir-4477a (MIRT557132)
- hsa-mir-889-3p (MIRT557133)
- hsa-mir-548au-3p (MIRT557134)
- hsa-mir-5589-3p (MIRT557135)
- hsa-mir-496 (MIRT557136)
- hsa-mir-17-3p (MIRT557137)
- hsa-mir-1205 (MIRT557138)
- hsa-mir-1184 (MIRT557139)
- hsa-mir-3158-5p (MIRT557140)
- hsa-mir-5190 (MIRT557141)
- hsa-mir-4496 (MIRT557142)
- hsa-mir-5197-5p (MIRT557143)
- hsa-mir-559 (MIRT557144)
- hsa-mir-548y (MIRT557145)
- hsa-mir-548w (MIRT557146)
- hsa-mir-548o-5p (MIRT557147)
- hsa-mir-548j-5p (MIRT557148)
- hsa-mir-548i (MIRT557149)
- hsa-mir-548h-5p (MIRT557150)
- hsa-mir-548d-5p (MIRT557151)
- hsa-mir-548c-5p (MIRT557152)
- hsa-mir-548bb-5p (MIRT557153)
- hsa-mir-548b-5p (MIRT557154)
- hsa-mir-548ay-5p (MIRT557155)
- hsa-mir-548au-5p (MIRT557156)
- hsa-mir-548as-5p (MIRT557157)
- hsa-mir-548ar-5p (MIRT557158)
- hsa-mir-548aq-5p (MIRT557159)
- hsa-mir-548ap-5p (MIRT557160)
- hsa-mir-548am-5p (MIRT557161)
- hsa-mir-548ak (MIRT557162)
- hsa-mir-548ae-5p (MIRT557163)
- hsa-mir-548ad-5p (MIRT557164)
- hsa-mir-548ab (MIRT557165)
- hsa-mir-548a-5p (MIRT557166)
- hsa-mir-583 (MIRT557167)
- hsa-mir-1276 (MIRT557168)
- hsa-mir-4311 (MIRT557169)
- hsa-mir-34c-5p (MIRT557170)
- hsa-mir-449a (MIRT557171)
- hsa-mir-449b-5p (MIRT557172)
- hsa-mir-34a-5p (MIRT557173)
- hsa-mir-6081 (MIRT562163)
- hsa-mir-8064 (MIRT562164)
- hsa-mir-4254 (MIRT562165)
- hsa-mir-3620-3p (MIRT562166)
- hsa-mir-4308 (MIRT562167)
- hsa-mir-92b-3p (MIRT562168)
- hsa-mir-92a-3p (MIRT562169)
- hsa-mir-367-3p (MIRT562170)
- hsa-mir-363-3p (MIRT562171)
- hsa-mir-32-5p (MIRT562172)
- hsa-mir-25-3p (MIRT562173)
- hsa-mir-504-5p (MIRT562174)
- hsa-mir-4290 (MIRT627037)
- hsa-mir-6809-3p (MIRT627038)
- hsa-mir-6833-3p (MIRT627039)
- hsa-mir-4768-5p (MIRT627040)
- hsa-mir-6873-3p (MIRT627041)
- hsa-mir-6749-3p (MIRT627042)
- hsa-mir-6792-3p (MIRT627043)
- hsa-mir-4691-5p (MIRT627044)
- hsa-mir-539-3p (MIRT627045)
- hsa-mir-485-3p (MIRT627046)
- hsa-mir-1236-3p (MIRT627047)
- hsa-mir-6515-3p (MIRT627048)
- hsa-mir-6845-3p (MIRT627049)
- hsa-mir-660-3p (MIRT627050)
- hsa-mir-5193 (MIRT627051)
- hsa-mir-1-5p (MIRT627052)
- hsa-mir-3675-3p (MIRT627053)
miRNA Products
- Search ViGene Biosciences for HOXA13
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXA13
- Browse OriGene Inhibitory RNA Products For HOXA13
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA13 gene
Clone Products
-
OriGene ORF clones in human for HOXA13
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXA13
Cell Line Products
-
Horizon Cell Lines for HOXA13
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXA13 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA13 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA13 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HOXA13 Gene
Localization for HOXA13 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXA13 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0045111 | intermediate filament cytoskeleton | IDA | -- |
Pathways & Interactions for HOXA13 Gene
No Data Available
Interacting Proteins for HOXA13 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | TAS | 9020844 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
No data available for Pathways by source for HOXA13 Gene
Transcripts for HOXA13 Gene
mRNA/cDNA for HOXA13 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (47) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXA13
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA13
- GenScript: Design CRISPR guide RNA sequences for HOXA13
miRNA Products
- Search ViGene Biosciences for HOXA13
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOXA13
- Browse OriGene Inhibitory RNA Products For HOXA13
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA13 gene
Clone Products
-
OriGene ORF clones in human for HOXA13
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOXA13
Flow Cytometry Products
Expression for HOXA13 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- NULL (Uncategorized)
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
- Prechondrocytic Mesenchymal Cells Autopod
- Bone (Muscoskeletal System)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
- Cartilage (Muscoskeletal System)
- Lower Urinary Tract (Urinary System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for HOXA13 Gene
This gene is overexpressed in Cervix - Ectocervix (x11.5), Cervix - Endocervix (x11.2), Vagina (x7.6), Bladder (x7.0), Prostate (x4.9), and Colon - Transverse (x4.5).
This gene is overexpressed in Cervix (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA13 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOXA13 Gene:
HOXA13SOURCE GeneReport for Unigene cluster for HOXA13 Gene:
Hs.592172Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA13 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- immune
- integumentary
- reproductive
- skeletal muscle
- skeleton
- urinary
Organs:
Abdomen:
- kidney
Pelvis:
- ovary
- penis
- ureter
- urethra
- urinary bladder
- uterus
- vagina
Limb:
- digit
- finger
- foot
- hand
- lower limb
- nail
- toe
- upper limb
General:
- blood
- skin
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for HOXA13
-
OriGene qPCR primer pairs and template standards for HOXA13
No data available for mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for HOXA13 Gene
Orthologs for HOXA13 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXA13 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXA13 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXA13 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Hoxa13 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxa13 34 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXA13 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXA13 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXA13 35 35 35 |
|
OneToMany | |
| LOC100859005 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | HOXA13 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxa13 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | hoxa13-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxa13b 34 35 |
|
||
| hoxa13a 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | Abd-B 35 |
|
OneToMany |
- Species where no ortholog for HOXA13 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXA13 Gene
Paralogs for HOXA13 Gene
(5) SIMAP similar genes for HOXA13 Gene using alignment to 3 proteins:
Variants for HOXA13 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs121912542 | Pathogenic, Hand-foot-genital syndrome (HFG) [MIM:140000] | 27,198,251(-) | TCCAG(A/C)ACAGG | reference, missense | |
| VAR_017775 | Guttmacher syndrome (GUTTS) [MIM:176305] | ||||
| VAR_075341 | Hand-foot-genital syndrome (HFG) [MIM:140000] | ||||
| VAR_075342 | Hand-foot-genital syndrome (HFG) [MIM:140000] | ||||
| rs104894019 | Pathogenic | 27,198,258(-) | ATCTG(A/G)TTCCA | reference, stop-gained |
Residual Variation Intolerance Score:
51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.41;
42.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXA13 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA13 Gene
Disorders for HOXA13 Gene
(9) MalaCards diseases for HOXA13 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hand-foot-uterus syndrome |
|
|
| guttmacher syndrome |
|
|
| hypospadias |
|
|
| triphalangeal thumb |
|
|
| invasive bladder transitional cell carcinoma |
|
|
Search HOXA13 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HXA13_HUMAN- Guttmacher syndrome (GUTTS) [MIM:176305]: Dominantly inherited combination of distal limb and genital tract abnormalities. It has several features in common with hand-foot-genital syndrome, including hypoplastic first digits and hypospadias. Typical features not seen in hand-foot-genital syndrome include postaxial polydactyly of the hands and uniphalangeal second toes with absent nails. {ECO:0000269 PubMed:11968094}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Hand-foot-genital syndrome (HFG) [MIM:140000]: A disorder characterized by limb and genitourinary anomalies. Clinical features include small feet with unusually short great toes and abnormal thumbs. Females with the disorder have duplication of the genital tract. {ECO:0000269 PubMed:10839976, ECO:0000269 PubMed:12073020, ECO:0000269 PubMed:24934387, ECO:0000269 PubMed:26590955}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HOXA13
No data available for Genatlas for HOXA13 Gene
Publications for HOXA13 Gene
- A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome. (PMID: 11968094) Innis J.W. … Guttmacher A.E. (Hum. Mutat. 2002) 3 4 22 64
- Novel HOXA13 mutations and the phenotypic spectrum of hand-foot- genital syndrome. (PMID: 10839976) Goodman F.R. … Scambler P.J. (Am. J. Hum. Genet. 2000) 3 4 22 64
- Mutation of HOXA13 in hand-foot-genital syndrome. (PMID: 9020844) Mortlock D.P. … Innis J.W. (Nat. Genet. 1997) 3 4 22 64
- Dual genetic diagnoses: Atypical hand-foot-genital syndrome and developmental delay due to de novo mutations in HOXA13 and NRXN1. (PMID: 26590955) Wallis M. … Patel C. (Am. J. Med. Genet. A 2015) 3 4 64
- Structural basis for sequence specific DNA binding and protein dimerization of HOXA13. (PMID: 21829694) Zhang Y. … Ames J.B. (PLoS ONE 2011) 3 4 64
Products for HOXA13 Gene
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for HOXA13
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for HOXA13
- Origene Custom Protein Services for HOXA13
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOXA13
- Browse OriGene Inhibitory RNA Products For HOXA13
- OriGene qPCR primer pairs and template standards for HOXA13
- OriGene qPCR primer pairs for HOXA13
- OriGene CRISPR knockouts for HOXA13
- OriGene ORF clones in human for HOXA13
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HOXA13
- GenScript: Next-day shipping cDNA ORF clone for HOXA13 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HOXA13
- GenScript Custom Assay Services for HOXA13
- GenScript Custom overexpressing Cell Line Services for HOXA13
- GenScript: Design CRISPR guide RNA sequences for HOXA13
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HOXA13
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HOXA13
- Novus Biologicals proteins for HOXA13
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Addgene plasmids for HOXA13
- antibodies-online Antibodies for HOXA13: See all 40
- Search antibodies-online for kits
- antibodies-online Proteins for HOXA13: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Antibodies for HOXA13
- Search GeneTex for Proteins for HOXA13
- ViGene Biosciences adenoviral particle packaged cDNA for HOXA13 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HOXA13 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HOXA13 gene
- Search ViGene Biosciences for HOXA13
- Horizon Cell Lines for HOXA13
- Cyagen custom Knockout/knockin (KOKI) mouse models for HOXA13
- VectorBuilder custom plasmid, inducible vectors for HOXA13
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOXA13
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXA13 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer