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HOXA13 Gene

protein-coding   GIFtS: 58
GCID: GC07M027256

Homeobox A13

(Previous name: homeo box A13)
(Previous symbols: HOX1J, HOX1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox A131 2     Homeo Box 1J2
HOX1J1 2 3 5     Homeobox Protein Hox-A132
HOX11 2     Homeobox Protein HOXA132
Homeo Box A131 2     Transcription Factor HOXA132
Homeobox Protein Hox-1J2 3     

External Ids:    HGNC: 51021   Entrez Gene: 32092   Ensembl: ENSG000001060317   OMIM: 1429595   UniProtKB: P312713   

Export aliases for HOXA13 gene to outside databases

Previous GC identifers: GC07M026880 GC07M026944 GC07M026978 GC07M027009 GC07M027203 GC07M027235 GC07M027246


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXA13 Gene:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters
named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally
regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a
DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation.
Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as
hand-foot-genital syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXA13 Gene:
HOXA13 (homeobox A13) is a protein-coding gene. Diseases associated with HOXA13 include hand-foot-genital syndrome, and hand foot uterus syndrome. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271
Function: Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory
system that provides cells with specific positional identities on the anterior-posterior axis
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXA13 gene promoter:
         E2F-1   p53   AP-1   ATF-2   MyoD   c-Jun   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOXA13 promoter sequence
   Search Chromatin IP Primers for HOXA13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXA13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA13 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027256:  view genomic region     (about GC identifiers)

Start:
27,233,122 bp from pter      End:
27,239,725 bp from pter
Size:
6,604 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,287,684-27,290,909     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271 (See protein sequence)
Recommended Name: Homeobox protein Hox-A13  
Size: 388 amino acids; 39727 Da
Subunit: Binds DNA as a homodimer. Interacts with MEIS1, MEIS2 and MEIS3 (By similarity)
1 PDB 3D structure from and Proteopedia for HOXA13:
2L7Z (3D)    
Secondary accessions: A4D188 O43371

Explore the universe of human proteins at neXtProt for HOXA13: NX_P31271

Explore proteomics data for HOXA13 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys303
  • Modification sites at PhosphoSitePlus

  • See HOXA13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000513.2  
    ENSEMBL proteins: 
     ENSP00000222753  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    4 InterPro protein domains:
     IPR022067 HoxA13_N
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P31271

    ProtoNet protein and cluster: P31271

    UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXA13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXA13_HUMAN, P31271
    Function: Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory
    system that provides cells with specific positional identities on the anterior-posterior axis
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXA13:
    homeo box A13(1J),homologous to mouse Hox-1.10 (hypodactyly),expressed in the developing lower genitourinary tract
    (abnormal seminal vesicle and prostate development),altered in hypodactyly mutants

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9020844
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
    GO:0044212transcription regulatory region DNA binding IEA--
         
    HOXA13 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXA13:
     Upregulation of Wnt/beta-caten 

         13 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Hoxa13):
     cardiovascular system  digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging  renal/urinary system 
     reproductive system  skeleton  vision/eye 

    HOXA13 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXA13: Hoxa13tm1Ipc Hoxa13tm2Ipc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXA13
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    miRNA
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    miRTarBase miRNAs that target HOXA13:
    hsa-mir-215-5p (MIRT024658), hsa-mir-222-3p (MIRT046676), hsa-mir-760 (MIRT036765), hsa-mir-142-3p (MIRT021544), hsa-mir-125b-5p (MIRT045907), hsa-mir-192-5p (MIRT026124)

    Block miRNA regulation of human, mouse, rat HOXA13 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate HOXA13:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-1285 hsa-miR-511 hsa-miR-612 hsa-miR-130b* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidHOXA13 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HOXA13

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA13

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXA13_HUMAN, P31271: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0045111intermediate filament cytoskeleton IDA--

    HOXA13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HOXA13
    Interactions:

        Search GeneGlobe Interaction Network for HOXA13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for HOXA13 (P312713 ENSP000002227534) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=2 STRING: ENSP00000272369
    SMAD2Q157963, ENSP000002621604I2D: score=1 STRING: ENSP00000262160
    MEIS2O147703, ENSP000003262964I2D: score=2 STRING: ENSP00000326296
    MEIS3Q996873, ENSP000003335524I2D: score=3 STRING: ENSP00000333552
    SMAD1Q157973, ENSP000003057694I2D: score=1 STRING: ENSP00000305769
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS9020844
    GO:0001570vasculogenesis IEA--
    GO:0001886endothelial cell morphogenesis IEA--
    GO:0001894tissue homeostasis IEA--
    GO:0003281ventricular septum development IEA--

    HOXA13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXA13 (HXA13)

    1 Novoseek inferred chemical compound relationship for HOXA13 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alanine 13.7 1 17935235 (1)



    HOXA13 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOXA13 gene: 
    NM_000522.4  

    Unigene Cluster for HOXA13:

    Homeobox A13
    Hs.592172  [show with all ESTs]
    Unigene Representative Sequence: NM_000522
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000518136 ENST00000222753(uc003szb.1)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate HOXA13:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-1285 hsa-miR-511 hsa-miR-612 hsa-miR-130b* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidHOXA13 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HOXA13
      QuantiFast Probe-based Assays in human, mouse, rat HOXA13

    Additional mRNA sequence: 

    BC016712.1 BC075791.1 

    1 DOTS entry:

    DT.443168 

    Selected AceView cDNA sequences (see all 47):

    BG260781 BE784076 BF055200 BQ025175 BQ022750 NM_000522 BQ024387 R80259 
    BF589601 AI080175 BF221789 AI659273 BX119246 BU617759 AI695522 AW364757 
    BC016712 AI680626 AA088393 BX439546 BQ022936 AA595017 AI680621 BG289306 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXA13 expression in normal human tissues (normalized intensities)      HOXA13 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTGTGT
    HOXA13 Expression
    About this image


    HOXA13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Autopod
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Autopod
             Autopod Long Bone
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Autopod
     
     NULL (Uncategorized)    fully expand to see all 3 entries
             Vascular endothelial growth factor-induced embryoid bodies
    HOXA13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXA13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592172
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOXA13 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxa131 , 5 homeobox A131, 5 91.02(n)1
    98.19(a)1
      6 (25.41 cM)5
    153981  NM_008264.11  NP_032290.11 
     522576945 
    chicken
    (Gallus gallus)
    Aves LOC1008590051 homeobox protein Hox-A13-like 81.31(n)
    83.93(a)
      100859005  XM_003640709.2  XP_003640757.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXA136
    homeobox A13
    46(a)
    1 ↔ 1
    GL343275.1(1375087-1379934)
    African clawed frog
    (Xenopus laevis)
    Amphibia hoxa13-A2 homeo box A13 78.93(n)    AJ314743.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxa13b2 homeo box A13b 73.58(n)   30438  NM_131194.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Abd-B6
    Abdominal B
    16(a)
    1 → many
    3R(12752932-12797958)


    ENSEMBL Gene Tree for HOXA13 (if available)
    TreeFam Gene Tree for HOXA13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXA13 gene
    HOXD112  ENSG000002571842  HOXD102  HOXC132  HOXC102  HOXD122  HOXA92  HOXC92  
    HOXB132  HOXC122  HOXC112  HOXD132  HOXA112  HOXB92  HOXD92  HOXA102  
    5 SIMAP similar genes for HOXA13 using alignment to 3 protein entries:     HXA13_HUMAN (see all proteins):
    HOXB1    HOXC13    HOXA4    HOXB13    HOXD13

    HOXA13 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXA13 (see all 143)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0177764
    Hand-foot-genital syndrome (HFG)4--see VAR_0177762 N H mis40--------
    VAR_0177754
    Guttmacher syndrome (GUTTS)4--see VAR_0177752 Q L mis40--------
    rs1048940191,2
    Cpathogenic127289061(-) ATCTGA/GTTCCA 2 * W stg10--------
    rs23913971,2
    C,F,H--27236558(+) AAGGGG/TTTTTT 1 -- ut31 trp312Minor allele frequency- T:0.25NS EA NA CSA 1009
    rs602508691,2
    C--27236558(+) AAGGG-/TTTTTT 1 -- ut312Minor allele frequency- T:0.25NA CSA 4
    rs1155250241,2
    C--27236559(+) AGGGTG/TTTTTT 1 -- ut310--------
    rs1822187831,2
    --27287185(+) GTGGCG/TCCCTT 1 -- ds50010--------
    rs1488785821,2
    --27287196(+) GATCTA/GCTAAT 1 -- ds50010--------
    rs1434724931,2
    C--27287211(+) CTAAGA/GCCAAT 1 -- ds50010--------
    rs1480067511,2
    --27287259(+) TTTTTC/TCGTCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for HOXA13 (27233122 - 27239725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HOXA13 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5675CNV Insertion18451855
    nsv887856CNV Loss21882294
    dgv7239n71CNV Loss21882294
    dgv7237n71CNV Loss21882294
    nsv887891CNV Loss21882294
    dgv7231n71CNV Loss21882294
    dgv7234n71CNV Loss21882294
    dgv7238n71CNV Loss21882294
    nsv824042CNV Gain20364138
    dgv1094n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): HOXA13
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXA13
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXA13

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142959   
    OMIM disorders: 140000  176305  
    UniProtKB/Swiss-Prot: HXA13_HUMAN, P31271
  • Hand-foot-genital syndrome (HFG) [MIM:140000]: A disorder characterized by limb and genitourinary
    anomalies. Clinical features include small feet with unusually short great toes and abnormal thumbs. Females with
    the disorder have duplication of the genital tract. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Guttmacher syndrome (GUTTS) [MIM:176305]: Dominantly inherited combination of distal limb and genital
    tract abnormalities. It has several features in common with hand-foot-genital syndrome, including hypoplastic
    first digits and hypospadias. Typical features not seen in hand-foot-genital syndrome include postaxial
    polydactyly of the hands and uniphalangeal second toes with absent nails. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for HOXA13 (see all 30):    About MalaCards
    hand-foot-genital syndrome    hand foot uterus syndrome    triphalangeal thumbs brachyectrodactyly    preaxial deficiency, postaxial polydactyly and hypospadias
    triphalangeal thumb    labyrinthitis    hypospadias    split hand
    vaginitis    esophageal squamous cell carcinoma    brachydactyly    hirschsprung's disease
    polydactyly    microphthalmia    urethritis    ulcerative colitis
    short stature    acute myeloid leukemia    lymphoblastic leukemia    infertility

    2 diseases from the University of Copenhagen DISEASES database for HOXA13:
    Hypospadias     Polydactyly

    HOXA13 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for HOXA13 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hand-foot-genital syndrome 97.6 8 9020844 (2), 10839976 (1), 12676922 (1), 15643670 (1) (see all 7)
    hypospadias 63.5 4 14675924 (4)
    cancer 0 1 19491265 (1)

    GeneTests: HOXA13
    GeneReviews: HOXA13
    Genetic Association Database (GAD): HOXA13
    Human Genome Epidemiology (HuGE) Navigator: HOXA13 (5 documents)

    Export disorders for HOXA13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXA13 gene, integrated from 10 sources (see all 74):
    (articles sorted by number of sources associating them with HOXA13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel HOXA13 mutations and the phenotypic spectrum of hand-foot- genital syndrome. (PubMed id 10839976)1, 2, 9 Goodman F.R.... Scambler P.J. (Am. J. Hum. Genet. 2000)
    2. A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome. (PubMed id 11968094)1, 2, 9 Innis J.W.... Guttmacher A.E. (Hum. Mutat. 2002)
    3. Mutation of HOXA13 in hand-foot-genital syndrome. (PubMed id 9020844)1, 2, 9 Mortlock D.P. and Innis J.W. (Nat. Genet. 1997)
    4. Structural basis for sequence specific DNA binding and protein dimerization of HOXA13. (PubMed id 21829694)1, 2 Zhang Y.... Ames J.B. (PLoS ONE 2011)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    6. Correlation between genetic variations in Hox clusters and Hirschsprung's disease. (PubMed id 17274802)1, 4 Garcia-BarcelA^ M.M....Tam P.K. (Ann. Hum. Genet. 2007)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. A novel stable polyalanine [poly(A)] expansion in the HOXA13 gene associated with hand-foot-genital syndrome: proper function of poly(A)-harbouring transcription factors depends on a critical repeat length? (PubMed id 12073020)1, 2 Utsch B....Ludwig M. (Hum. Genet. 2002)
    10. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3209 HGNC: 5102 AceView: HOXA13 Ensembl:ENSG00000106031 euGenes: HUgn3209
    ECgene: HOXA13 H-InvDB: HOXA13

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXA13 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HOXA13 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=HOXA13[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXA13 gene:
    Search GeneIP for patents involving HOXA13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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