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HOXA11 Gene

protein-coding   GIFtS: 59
GCID: GC07M027220

Homeobox A11

(Previous name: homeo box A11)
(Previous symbols: HOX1I, HOX1)
  See HOXA11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox A111 2     Homeo Box A111
HOX1I1 2 3 5     Homeo Box 1I2
HOX11 2     Homeobox Protein Hox-A112
Homeobox Protein Hox-1I2 3     Homeobox Protein HOXA112

External Ids:    HGNC: 51011   Entrez Gene: 32072   Ensembl: ENSG000000050737   OMIM: 1429585   UniProtKB: P312703   

Export aliases for HOXA11 gene to outside databases

Previous GC identifers: GC07M026864 GC07M026929 GC07M026963 GC07M026994 GC07M027187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXA11 Gene:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters
named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally
regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a
DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This
gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this
gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOXA11 Gene:
HOXA11 (homeobox A11) is a protein-coding gene. Diseases associated with HOXA11 include synostosis, and radioulnar synostosis with amegakaryocytic thrombocytopenia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot: HXA11_HUMAN, P31270
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXA11 gene promoter:
         p53   ATF-2   MyoD   c-Jun   YY1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOXA11 promoter sequence
   Search Chromatin IP Primers for HOXA11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXA11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA11 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027220:  view genomic region     (about GC identifiers)

Start:
27,220,776 bp from pter      End:
27,224,842 bp from pter
Size:
4,067 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,271,961-27,276,020     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HXA11_HUMAN, P31270 (See protein sequence)
Recommended Name: Homeobox protein Hox-A11  
Size: 313 amino acids; 34486 Da
Secondary accessions: A4D190

Explore the universe of human proteins at neXtProt for HOXA11: NX_P31270

Explore proteomics data for HOXA11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys72
  • Modification sites at PhosphoSitePlus

  • See HOXA11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005514.1  
    ENSEMBL proteins: 
     ENSP00000448962   ENSP00000006015  

    HOXA11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for HOXA11

     
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    antibodies-online proteins for HOXA11 (6 products) 

     
    antibodies-online peptides for HOXA11

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5 InterPro protein domains:
     IPR021918 DUF3528
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P31270

    ProtoNet protein and cluster: P31270

    UniProtKB/Swiss-Prot: HXA11_HUMAN, P31270
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Find genes that share domains with HOXA11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXA11_HUMAN, P31270
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis

         Genatlas biochemistry entry for HOXA11:
    homeo box A11(1I),homologous to mouse Hox-1.9

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding ----
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with HOXA11           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hoxa11):
     cellular  endocrine/exocrine gland  limbs/digits/tail  mortality/aging  no phenotypic analysis 
     renal/urinary system  reproductive system  skeleton 

    Find genes that share phenotypes with HOXA11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for HOXA11: Hoxa11tm1Mrc Hoxa11tm1Ssp Hoxa11tm2(Hoxa13)Ssp

       genOway: Develop your customized and physiologically relevant rodent model for HOXA11

    miRNA
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    miRTarBase miRNAs that target HOXA11:
    hsa-mir-30d-5p (MIRT047784), hsa-mir-484 (MIRT041937), hsa-mir-769-3p (MIRT039124), hsa-mir-335-5p (MIRT017072)

    Block miRNA regulation of human, mouse, rat HOXA11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXA11 (see all 43):
    hsa-miR-21* hsa-miR-607 hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-200a hsa-miR-30d hsa-miR-4315 hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidHOXA11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HOXA11

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXA11_HUMAN, P31270: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex ISS--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm ----
    GO:0032993protein-DNA complex ISS--

    Find genes that share ontologies with HOXA11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HOXA11 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with HOXA11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for HOXA11):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including HOXA11: 
              Stem Cell Transcription Factors in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for HOXA11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for HOXA11 (P312703 ENSP000000060154) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEIS1O004703, ENSP000002723694I2D: score=3 STRING: ENSP00000272369
    FOXO1Q127783, ENSP000003688804I2D: score=1 STRING: ENSP00000368880
    HRO435933, ENSP000003708264I2D: score=1 STRING: ENSP00000370826
    HDAC1Q135473, ENSP000003626494I2D: score=1 STRING: ENSP00000362649
    HDAC2Q927693, ENSP000003813314I2D: score=1 STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development ISS--
    GO:0001656metanephros development IEA--
    GO:0001658branching involved in ureteric bud morphogenesis ISS--
    GO:0001759organ induction IEA--
    GO:0006351transcription, DNA-templated IEA--

    Find genes that share ontologies with HOXA11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXA11 (HXA11)

    2 Novoseek inferred chemical compound relationships for HOXA11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 42.5 2 20104430 (1), 10084606 (1)
    alanine 0.791 1 11083943 (1)



    Find genes that share compounds with HOXA11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOXA11 gene: 
    NM_005523.5  

    Unigene Cluster for HOXA11:

    Homeobox A11
    Hs.249171  [show with all ESTs]
    Unigene Representative Sequence: NM_005523
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000517402(uc003syy.3) ENST00000006015(uc003syx.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat HOXA11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXA11 (see all 43):
    hsa-miR-21* hsa-miR-607 hsa-miR-3607-3p hsa-miR-218-1* hsa-miR-200a hsa-miR-30d hsa-miR-4315 hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidHOXA11 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HOXA11
      QuantiFast Probe-based Assays in human, mouse, rat HOXA11

    Additional mRNA sequence: 

    AK313921.1 BC033706.1 BC040948.1 

    4 DOTS entries:

    DT.86821403  DT.101978976  DT.100645680  DT.121079900 

    Selected AceView cDNA sequences (see all 69):

    CA426464 AI627364 BE221446 BX383838 AI680392 N26932 AI093274 CA426472 
    CR611111 BQ015261 AA653295 BX101301 AI061150 BX401341 BX423110 CB051905 
    AI597898 BC040948 BM797328 BM991756 H91677 BX377365 CR612696 BG315256 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXA11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATAGCCC
    HOXA11 Expression
    About this image


    HOXA11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Kidney (Urinary System)    fully expand to see all 5 entries
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
             Interstitial Stroma
             mK3
             Metanephric mesenchyme progenitor cells
     
     Limb (Muscoskeletal System)    fully expand to see all 5 entries
             Limb Bud Mesenchyme Cells Limb Bud
             Stylopod Synovial Joint
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Mesoderm (Gastrulation Derivatives)
             Limb Bud Mesenchyme Cells Limb Bud
    HOXA11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXA11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.249171
        Pathway & Disease-focused RT2 Profiler PCR Array including HOXA11: 
              Stem Cell Transcription Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HOXA11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxa111 , 5 homeobox A111, 5 94.64(n)1
    96.14(a)1
      6 (25.40 cM)5
    153961  NM_010450.31  NP_034580.11 
     522421085 
    chicken
    (Gallus gallus)
    Aves LOC1008589671 homeobox protein Hox-A11-like 81.42(n)
    80.41(a)
      100858967  XM_003640708.2  XP_003640756.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOXA116
    homeobox A11
    69(a)
    1 ↔ 1
    GL343275.1(1402995-1409378)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.160372 Xenopus laevis transcribed sequence with weak similarity more 80.69(n)    BJ066744.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxa11b2 homeo box A11b 76.03(n)   30382  NM_131147.1 


    ENSEMBL Gene Tree for HOXA11 (if available)
    TreeFam Gene Tree for HOXA11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXA11 gene
    HOXD112  ENSG000002571842  HOXD102  HOXC132  HOXC102  HOXD122  HOXA92  HOXA132  
    HOXC92  HOXB132  HOXC122  HOXC112  HOXD132  HOXB92  HOXD92  HOXA102  
    9 SIMAP similar genes for HOXA11 using alignment to 2 protein entries:     HXA11_HUMAN (see all proteins):
    HOX B6    HOXA4    HOXC13    HOXD11    HOXA-9    HOXC11
    HOXB1    HOXA10    HOXB9

    Find genes that share paralogs with HOXA11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOXA11 (see all 173)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507833681,2
    --27186175(+) AGCAGA/CCTCAG 1 -- ds50010--------
    rs358654211,2
    C--27186370(+) GCCCTC/TTCCAG 1 -- ds50010--------
    rs1424941141,2
    --27186455(+) AAGGAC/TGTAGC 1 -- ds50010--------
    rs745325791,2
    C--27186456(+) AGGACG/ATAGCC 1 -- ds50012Minor allele frequency- A:0.02NA 122
    rs125341101,2
    C,H--27186618(+) AAAGGC/TGATCA 1 -- ds50014Minor allele frequency- T:0.00NS EA 416
    rs2010600891,2
    --27186662(+) TCCAC-/CGTCTTT 1 -- ut310--------
    rs1998207151,2
    --27186666(+) CCGTC-/TTTATTT 1 -- ut310--------
    rs102443261,2
    C,F,H--27186682(+) TGTGCC/TCAGTT 1 -- ut314Minor allele frequency- T:0.00NS EA 412
    rs64619921,2
    C,F,A,H--27186705(+) GCTGCG/AACACA 1 -- ut3123Minor allele frequency- A:0.14NS EA NA WA CSA 2344
    rs1824347741,2
    --27186712(+) CACACA/GCGGTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for HOXA11 (27220776 - 27224842 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HOXA11 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5675CNV Insertion18451855
    nsv887856CNV Loss21882294
    dgv7239n71CNV Loss21882294
    dgv7237n71CNV Loss21882294
    nsv887891CNV Loss21882294
    dgv7231n71CNV Loss21882294
    dgv7234n71CNV Loss21882294
    dgv7238n71CNV Loss21882294
    nsv824042CNV Gain20364138
    dgv1094n67CNV Gain20364138

    Human Gene Mutation Database (HGMD): HOXA11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOXA11
    DNA2.0 Custom Variant and Variant Library Synthesis for HOXA11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142958   
    OMIM disorders: 605432  
    UniProtKB/Swiss-Prot: HXA11_HUMAN, P31270
  • Radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT) [MIM:605432]: The syndrome consists of
    an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the
    proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm.
    Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth,
    necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 8 diseases for HOXA11:    
    About MalaCards
    synostosis    radioulnar synostosis with amegakaryocytic thrombocytopenia    endometrial adenocarcinoma    radioulnar synostosis
    ectopic pregnancy    thrombocytopenia    clubfoot    cutaneous malignant melanoma

    1 disease from the University of Copenhagen DISEASES database for HOXA11:
    Radioulnar synostosis

    Find genes that share disorders with HOXA11           About GenesLikeMe

    3 Novoseek inferred disease relationships for HOXA11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    synostosis 51.6 3 16765069 (2), 11101832 (1)
    thrombocytopenia 7.55 2 16765069 (1), 11101832 (1)
    leukemia 6.64 2 16765069 (1), 11841413 (1)

    Genetic Association Database (GAD): HOXA11
    Human Genome Epidemiology (HuGE) Navigator: HOXA11 (5 documents)

    Export disorders for HOXA11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXA11 gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with HOXA11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PubMed id 19255789)1, 4, 9 Bouba I....Georgiou I. (Pediatr. Nephrol. 2009)
    2. Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation. (PubMed id 11101832)1, 2, 9 Thompson A.A. and Nguyen L.T. (Nat. Genet. 2000)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    4. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    8. Evolutionary conservation and tissue-specific processing of hoxa 11 antisense transcripts. (PubMed id 9745033)1, 2 Potter S.S. and Branford W.W. (Mamm. Genome 1998)
    9. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)
    10. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (Genomics 1990)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3207 HGNC: 5101 AceView: HOXA11 Ensembl:ENSG00000005073 euGenes: HUgn3207
    ECgene: HOXA11 Kegg: 3207 H-InvDB: HOXA11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HOXA11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HOXA11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HOXA11 gene:
    Search GeneIP for patents involving HOXA11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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