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Aliases for HOXA11 Gene

Aliases for HOXA11 Gene

  • Homeobox A11 2 3
  • HOX1I 3 4 6
  • Homeobox Protein Hox-1I 3 4
  • Homeobox Protein Hox-A11 3
  • Homeobox Protein HOXA11 3
  • Homeo Box A11 2
  • Homeo Box 1I 3
  • HOX1 3

External Ids for HOXA11 Gene

Previous HGNC Symbols for HOXA11 Gene

  • HOX1I
  • HOX1

Previous GeneCards Identifiers for HOXA11 Gene

  • GC07M026864
  • GC07M026929
  • GC07M026963
  • GC07M026994
  • GC07M027187
  • GC07M027220

Summaries for HOXA11 Gene

Entrez Gene Summary for HOXA11 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA11 Gene

HOXA11 (Homeobox A11) is a Protein Coding gene. Diseases associated with HOXA11 include radioulnar synostosis with amegakaryocytic thrombocytopenia and endometrial adenocarcinoma. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXA11 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA11 Gene

Genomics for HOXA11 Gene

Regulatory Elements for HOXA11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXA11 Gene

27,181,157 bp from pter
27,185,223 bp from pter
4,067 bases
Minus strand

Genomic View for HOXA11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA11 Gene

Proteins for HOXA11 Gene

  • Protein details for HOXA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Hox-A11
    Protein Accession:
    Secondary Accessions:
    • A4D190

    Protein attributes for HOXA11 Gene

    313 amino acids
    Molecular mass:
    34486 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA11 Gene

Proteomics data for HOXA11 Gene at MOPED

Post-translational modifications for HOXA11 Gene

  • Ubiquitination at Lys72
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXA11 Gene

Domains for HOXA11 Gene

Gene Families for HOXA11 Gene

  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for HOXA11 Gene

Suggested Antigen Peptide Sequences for HOXA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P31270
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXA11: view

Function for HOXA11 Gene

Molecular function for HOXA11 Gene

GENATLAS Biochemistry:
homeo box A11(1I),homologous to mouse Hox-1.9
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXA11: view
genes like me logo Genes that share phenotypes with HOXA11: view

Animal Models for HOXA11 Gene

MGI Knock Outs for HOXA11:

Animal Model Products

miRNA for HOXA11 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXA11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXA11 Gene

Localization for HOXA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA11 Gene

Subcellular locations from

Jensen Localization Image for HOXA11 Gene COMPARTMENTS Subcellular localization image for HOXA11 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for HOXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005667 transcription factor complex ISS --
GO:0032993 protein-DNA complex ISS --
GO:0043234 protein complex ISS --
genes like me logo Genes that share ontologies with HOXA11: view

Pathways for HOXA11 Gene

genes like me logo Genes that share pathways with HOXA11: view

Pathways by source for HOXA11 Gene

1 KEGG pathway for HOXA11 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Stem Cell Transcription Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for HOXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development ISS --
GO:0001656 metanephros development IEA --
GO:0001658 branching involved in ureteric bud morphogenesis ISS --
GO:0001759 organ induction IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOXA11: view

Compounds for HOXA11 Gene

(2) Novoseek inferred chemical compound relationships for HOXA11 Gene

Compound -log(P) Hits PubMed IDs
progesterone 42.5 2
alanine 0.791 1
genes like me logo Genes that share compounds with HOXA11: view

Transcripts for HOXA11 Gene

mRNA/cDNA for HOXA11 Gene

(69) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXA11 Gene

Homeobox A11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXA11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA11 Gene

No ASD Table

Relevant External Links for HOXA11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOXA11 Gene

mRNA expression in normal human tissues for HOXA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA11 Gene

This gene is overexpressed in Uterus (14.2), Cervix - Endocervix (6.9), Cervix - Ectocervix (5.3), and Colon - Sigmoid (4.7).

SOURCE GeneReport for Unigene cluster for HOXA11 Gene Hs.249171

genes like me logo Genes that share expressions with HOXA11: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for HOXA11 Gene

Orthologs for HOXA11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXA11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HOXA11 35
  • 94.87 (n)
  • 96.79 (a)
HOXA11 36
  • 98 (a)
(Canis familiaris)
Mammalia HOXA11 35
  • 91.37 (n)
  • 91.69 (a)
HOXA11 36
  • 94 (a)
(Mus musculus)
Mammalia Hoxa11 35
  • 94.64 (n)
  • 96.14 (a)
Hoxa11 16
Hoxa11 36
  • 97 (a)
(Pan troglodytes)
Mammalia HOXA11 35
  • 95.74 (n)
  • 94.89 (a)
HOXA11 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC100911743 35
  • 94.32 (n)
  • 96.46 (a)
(Monodelphis domestica)
Mammalia HOXA11 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia HOXA11 36
  • 80 (a)
(Gallus gallus)
Aves LOC100858967 35
  • 81.42 (n)
  • 80.41 (a)
HOXA11 36
  • 84 (a)
(Anolis carolinensis)
Reptilia HOXA11 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa11 35
  • 76.78 (n)
  • 77.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16037 35
(Danio rerio)
Actinopterygii hoxa11b 35
  • 73.95 (n)
  • 89.66 (a)
hoxa11a 36
  • 67 (a)
hoxa11b 36
  • 73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7890 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
Species with no ortholog for HOXA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA11 Gene

Gene Tree for HOXA11 (if available)
Gene Tree for HOXA11 (if available)

Paralogs for HOXA11 Gene

Selected SIMAP similar genes for HOXA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXA11: view

Variants for HOXA11 Gene

Sequence variations from dbSNP and Humsavar for HOXA11 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs3210747 -- 27,182,503(-) TGGTC(C/T)CCAGC utr-variant-3-prime
rs17427861 -- 27,182,790(+) CCGCT(A/G)GAGTC utr-variant-3-prime
rs17501104 -- 27,182,304(+) TCACA(A/T)TGGCT utr-variant-3-prime
rs34878915 -- 27,182,348(+) TCCTA(-/C)CCCTT utr-variant-3-prime
rs60368266 -- 27,183,069(+) GTGGG(A/G)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOXA11 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7237n71 CNV Loss 21882294
dgv7238n71 CNV Loss 21882294
dgv7239n71 CNV Loss 21882294
nsv5675 CNV Insertion 18451855
nsv887891 CNV Loss 21882294

Relevant External Links for HOXA11 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA11 Gene

Disorders for HOXA11 Gene

(1) OMIM Diseases for HOXA11 Gene (142958)


  • Radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT) [MIM:605432]: The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. {ECO:0000269 PubMed:11101832}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for HOXA11 Gene

(3) Novoseek inferred disease relationships for HOXA11 Gene

Disease -log(P) Hits PubMed IDs
synostosis 51.6 3
thrombocytopenia 7.55 2
leukemia 6.64 2

Relevant External Links for HOXA11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HOXA11: view

No data available for Genatlas for HOXA11 Gene

Publications for HOXA11 Gene

  1. Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation. (PMID: 11101832) Thompson A.A. … Nguyen L.T. (Nat. Genet. 2000) 3 4 23
  2. Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PMID: 19255789) Bouba I. … Georgiou I. (Pediatr. Nephrol. 2009) 3 23 48
  3. HOXA11 promotes fibroblast proliferation and regulates p53 in uterosacral ligaments. (PMID: 19372592) Connell K.A. … Taylor H.S. (Reprod Sci 2009) 3 23
  4. HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. (PMID: 18274672) Connell K.A. … Taylor H.S. (J. Clin. Invest. 2008) 3 23
  5. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. (PMID: 15674412) Speleman F. … Hagemeijer A. (Leukemia 2005) 3 23

Products for HOXA11 Gene

Sources for HOXA11 Gene

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