Aliases for HOXA11 Gene
Aliases for HOXA11 Gene
External Ids for HOXA11 Gene
- HGNC: 5101
- Entrez Gene: 3207
- Ensembl: ENSG00000005073
- OMIM: 142958
- UniProtKB: P31270
Previous HGNC Symbols for HOXA11 Gene
- HOX1I
- HOX1
Previous GeneCards Identifiers for HOXA11 Gene
- GC07M026864
- GC07M026929
- GC07M026963
- GC07M026994
- GC07M027187
- GC07M027220
- GC07M027182
- GC07M027183
- GC07M027190
Summaries for HOXA11 Gene
-
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOXA11 Gene
HOXA11 (Homeobox A11) is a Protein Coding gene. Diseases associated with HOXA11 include Radioulnar Synostosis With Amegakaryocytic Thrombocytopenia and Synostosis. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXC11.
UniProtKB/Swiss-Prot for HOXA11 Gene
-
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA11 Gene
Genomics for HOXA11 Gene
Regulatory Elements for HOXA11 Gene
Enhancers for HOXA11 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOXA11 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOXA11 gene promoter:
Regulatory Element Products
Genomic Location for HOXA11 Gene
- Chromosome:
- 7
- Start:
- 27,181,157 bp from pter
- End:
- 27,185,223 bp from pter
- Size:
- 4,067 bases
- Orientation:
- Minus strand
Genomic View for HOXA11 Gene
Genes around HOXA11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p15.2 by Ensembl
- 7p15.2 by Entrez Gene
- 7p15.2 by HGNC
HOXA11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOXA11 Gene
Proteins for HOXA11 Gene
-
Protein details for HOXA11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P31270-HXA11_HUMAN
- Recommended name:
- Homeobox protein Hox-A11
- Protein Accession:
- P31270
- A4D190
Protein attributes for HOXA11 Gene
- Size:
- 313 amino acids
- Molecular mass:
- 34486 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for HOXA11 Gene
Other Protein References for HOXA11 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for HOXA11
- Novus Biologicals Antibodies for HOXA11
-
Abcam antibodies for HOXA11
- Invitrogen Antibodies for HOXA11
- antibodies-online Antibodies for HOXA11: See all 65
- GeneTex HOXA11 antibody for HOXA11
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOXA11
Protein Products
-
OriGene Purified Proteins for HOXA11
- Search Origene for MassSpec and Protein Over-expression Lysates for HOXA11
- Origene Custom Protein Services for HOXA11
- antibodies-online Proteins for HOXA11: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOXA11
-
Abcam proteins for HOXA11
Assay Products
No data available for DME Specific Peptides for HOXA11 Gene
Domains & Families for HOXA11 Gene
Gene Families for HOXA11 Gene
Protein Domains for HOXA11 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOXA11 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P31270- Family:
-
- Belongs to the Abd-B homeobox family.
Function for HOXA11 Gene
Molecular function for HOXA11 Gene
- GENATLAS Biochemistry:
- homeo box A11(1I),homologous to mouse Hox-1.9
- UniProtKB/Swiss-Prot Function:
- Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for HOXA11 Gene
- MGI mutant phenotypes for HOXA11:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for HOXA11:
Animal Models for HOXA11 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA11 gene
- Search ViGene Biosciences for HOXA11
CRISPR Products
-
OriGene CRISPR knockouts for HOXA11
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA11
- GenScript: Design CRISPR guide RNA sequences for HOXA11
miRNA for HOXA11 Gene
- miRTarBase miRNAs that target HOXA11
-
- hsa-mir-335-5p (MIRT017072)
- hsa-mir-769-3p (MIRT039124)
- hsa-mir-484 (MIRT041937)
- hsa-mir-30d-5p (MIRT047784)
- hsa-mir-211-3p (MIRT258341)
- hsa-mir-4270 (MIRT258346)
- hsa-mir-4441 (MIRT258348)
- hsa-mir-6754-5p (MIRT258352)
- hsa-mir-190a-3p (MIRT320498)
- hsa-mir-5011-5p (MIRT320501)
- hsa-mir-5692c (MIRT523140)
- hsa-mir-5692b (MIRT523141)
- hsa-mir-5584-5p (MIRT523142)
- hsa-mir-1277-5p (MIRT523143)
- hsa-mir-410-3p (MIRT523144)
- hsa-mir-374b-5p (MIRT523145)
- hsa-mir-369-3p (MIRT523146)
- hsa-mir-374a-5p (MIRT523147)
- hsa-mir-6868-3p (MIRT557174)
- hsa-mir-3127-5p (MIRT557175)
- hsa-mir-205-5p (MIRT557176)
miRNA Products
- Search ViGene Biosciences for HOXA11
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HOXA11
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA11 gene
Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HOXA11
-
ViGene Biosciences adenoviral particle packaged cDNA for HOXA11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOXA11 gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HOXA11 Gene
Localization for HOXA11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOXA11 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005667 | transcription factor complex | ISS,IEA | -- |
| GO:0032993 | protein-DNA complex | ISS,IEA | -- |
| GO:0043234 | protein complex | ISS,IEA | -- |
Pathways & Interactions for HOXA11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcriptional misregulation in cancer | ||
Pathways by source for HOXA11 Gene
1 KEGG pathway for HOXA11 Gene
Interacting Proteins for HOXA11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001501 | skeletal system development | ISS | -- |
| GO:0001656 | metanephros development | IEA | -- |
| GO:0001658 | branching involved in ureteric bud morphogenesis | ISS,IEA | -- |
| GO:0001759 | organ induction | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for HOXA11 Gene
Transcripts for HOXA11 Gene
mRNA/cDNA for HOXA11 Gene
- (1) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (69) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for HOXA11
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOXA11
- GenScript: Design CRISPR guide RNA sequences for HOXA11
miRNA Products
- Search ViGene Biosciences for HOXA11
Inhibitory RNA Products
- Origene RNAi, shRNA, and siRNA products in human, mouse, rat for HOXA11
- Browse OriGene Inhibitory RNA Products For HOXA11
-
ViGene Biosciences ready-to-package AAV shRNAs for HOXA11 gene
Clone Products
-
OriGene ORF clones in human for HOXA11
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HOXA11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Cartilage (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
- Prechondrocytic Mesenchymal Cells Vertebral Body
-
Bone (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Dorsal Neural Arch
- Prechondrocytic Mesenchymal Cells Lateral Neural Arch
- Prechondrocytic Mesenchymal Cells Spinous Process Of Vertebrae
- Prechondrocytic Mesenchymal Cells Central Neural Arch
- Prechondrocytic Mesenchymal Cells Vertebral Body
-
Kidney (Urinary System)
- Metanephric Mesenchyme Cells Metanephric Mesenchyme
- Cortical Stroma Cells Interstitial Stroma
- Interstitial Stroma
- mK4
- mK3
-
Limb (Muscoskeletal System)
- Prechondrocytic Mesenchymal Cells Zeugopod
- Interzone Cells Stylopod Synovial Joint
- Limb Bud Mesenchyme Cells Limb Bud
- Limb Muscle Progenitor Cells Forelimb Myotome
- Stylopod Synovial Joint
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Skeletal Muscle (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Uterus (Reproductive System)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for HOXA11 Gene
This gene is overexpressed in Uterus (x14.2), Cervix - Endocervix (x6.9), Cervix - Ectocervix (x5.3), and Colon - Sigmoid (x4.7).
NURSA nuclear receptor signaling pathways regulating expression of HOXA11 Gene:
HOXA11SOURCE GeneReport for Unigene cluster for HOXA11 Gene:
Hs.249171Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA11 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
- nervous
- skeletal muscle
- skeleton
Organs:
Pelvis:
- pelvis
Limb:
- arm
- digit
- femur
- finger
- foot
- forearm
- hand
- hip
- lower limb
- radius
- thigh
- toe
- ulna
- upper limb
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- red blood cell
- skin
Primer Products
-
OriGene qPCR primer pairs for HOXA11
-
OriGene qPCR primer pairs and template standards for HOXA11
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for HOXA11 Gene
Orthologs for HOXA11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOXA11 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOXA11 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoxa11 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hoxa11 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HOXA11 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOXA11 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOXA11 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOXA11 35 |
|
OneToOne | |
| LOC100858967 34 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | HOXA11 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoxa11 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16037 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | hoxa11b 34 35 |
|
||
| hoxa11a 35 |
|
OneToMany | |||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.7890 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOXA11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOXA11 Gene
Paralogs for HOXA11 Gene
(9) SIMAP similar genes for HOXA11 Gene using alignment to 2 proteins:
Variants for HOXA11 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs864321666 | Pathogenic | 27,182,866(-) | TCAGA(-/A)CAGGA | reference, frameshift-variant | |
| rs1001749900 | -- | 27,183,536(+) | GCCTG(A/C)GTCCT | intron-variant, upstream-variant-2KB | |
| rs1001802119 | -- | 27,183,165(+) | CCCCT(C/G)CCTTT | intron-variant | |
| rs1002295658 | -- | 27,186,580(+) | GTTTG(C/T)GCTAA | intron-variant, upstream-variant-2KB | |
| rs1002424431 | -- | 27,186,847(+) | ATATG(G/T)AAAAA | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.12;
22.81% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOXA11 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA11 Gene
Disorders for HOXA11 Gene
(6) MalaCards diseases for HOXA11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| radioulnar synostosis with amegakaryocytic thrombocytopenia |
|
|
| synostosis |
|
|
| radioulnar synostosis |
|
|
| thrombocytopenia |
|
|
| cervical incompetence |
|
|
Search HOXA11 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HXA11_HUMAN- Radioulnar synostosis with amegakaryocytic thrombocytopenia 1 (RUSAT1) [MIM:605432]: The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. {ECO:0000269 PubMed:11101832}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HOXA11
No data available for Genatlas for HOXA11 Gene
Publications for HOXA11 Gene
- Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PMID: 19255789) Bouba I. … Georgiou I. (Pediatr. Nephrol. 2009) 3 22 46 64
- Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation. (PMID: 11101832) Thompson A.A. … Nguyen L.T. (Nat. Genet. 2000) 3 4 22 64
- High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64
- DNA methylation analysis in liquid-based cytology for cervical cancer screening. (PMID: 19609949) Apostolidou S. … Widschwendter M. (Int. J. Cancer 2009) 3 22 64
- Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PMID: 19938081) Ester A.R. … Hecht J.T. (Am. J. Med. Genet. A 2009) 3 46 64
Products for HOXA11 Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOXA11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
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