Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HOXA11 Gene

Aliases for HOXA11 Gene

  • Homeobox A11 2 3 5
  • Homeobox Protein Hox-1I 3 4
  • HOX1I 3 4
  • Homeobox Protein HOXA11 3
  • Homeo Box A11 2
  • Homeo Box 1I 3
  • RUSAT1 3
  • HOX1 3

External Ids for HOXA11 Gene

Previous HGNC Symbols for HOXA11 Gene

  • HOX1I
  • HOX1

Previous GeneCards Identifiers for HOXA11 Gene

  • GC07M026864
  • GC07M026929
  • GC07M026963
  • GC07M026994
  • GC07M027187
  • GC07M027220
  • GC07M027182

Summaries for HOXA11 Gene

Entrez Gene Summary for HOXA11 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA11 Gene

HOXA11 (Homeobox A11) is a Protein Coding gene. Diseases associated with HOXA11 include radioulnar synostosis with amegakaryocytic thrombocytopenia and synostosis. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXA11 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXA11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA11 Gene

Genomics for HOXA11 Gene

Regulatory Elements for HOXA11 Gene

Enhancers for HOXA11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HOXA11 on UCSC Golden Path with GeneCards custom track

Promoters for HOXA11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HOXA11 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXA11 Gene

Chromosome:
7
Start:
27,181,157 bp from pter
End:
27,185,223 bp from pter
Size:
4,067 bases
Orientation:
Minus strand

Genomic View for HOXA11 Gene

Genes around HOXA11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA11 Gene

Proteins for HOXA11 Gene

  • Protein details for HOXA11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31270-HXA11_HUMAN
    Recommended name:
    Homeobox protein Hox-A11
    Protein Accession:
    P31270
    Secondary Accessions:
    • A4D190

    Protein attributes for HOXA11 Gene

    Size:
    313 amino acids
    Molecular mass:
    34486 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA11 Gene

Proteomics data for HOXA11 Gene at MOPED

Post-translational modifications for HOXA11 Gene

  • Ubiquitination at Lys 72
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXA11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXA11 Gene

Domains & Families for HOXA11 Gene

Gene Families for HOXA11 Gene

Protein Domains for HOXA11 Gene

Suggested Antigen Peptide Sequences for HOXA11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31270

UniProtKB/Swiss-Prot:

HXA11_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXA11: view

Function for HOXA11 Gene

Molecular function for HOXA11 Gene

GENATLAS Biochemistry:
homeo box A11(1I),homologous to mouse Hox-1.9
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
genes like me logo Genes that share phenotypes with HOXA11: view

Human Phenotype Ontology for HOXA11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HOXA11 Gene

MGI Knock Outs for HOXA11:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for HOXA11 Gene

Localization for HOXA11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA11 Gene COMPARTMENTS Subcellular localization image for HOXA11 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXA11 Gene

Pathways & Interactions for HOXA11 Gene

genes like me logo Genes that share pathways with HOXA11: view

Pathways by source for HOXA11 Gene

1 KEGG pathway for HOXA11 Gene

Gene Ontology (GO) - Biological Process for HOXA11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development ISS --
GO:0001656 metanephros development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA,ISS --
genes like me logo Genes that share ontologies with HOXA11: view

No data available for SIGNOR curated interactions for HOXA11 Gene

Drugs & Compounds for HOXA11 Gene

(2) Drugs for HOXA11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HOXA11: view

Transcripts for HOXA11 Gene

mRNA/cDNA for HOXA11 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(69) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXA11 Gene

Homeobox A11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA11 Gene

No ASD Table

Relevant External Links for HOXA11 Gene

GeneLoc Exon Structure for
HOXA11
ECgene alternative splicing isoforms for
HOXA11

Expression for HOXA11 Gene

mRNA expression in normal human tissues for HOXA11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA11 Gene

This gene is overexpressed in Uterus (x14.2), Cervix - Endocervix (x6.9), Cervix - Ectocervix (x5.3), and Colon - Sigmoid (x4.7).

SOURCE GeneReport for Unigene cluster for HOXA11 Gene Hs.249171

genes like me logo Genes that share expression patterns with HOXA11: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HOXA11 Gene

Orthologs for HOXA11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXA11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXA11 35
  • 94.87 (n)
  • 96.79 (a)
HOXA11 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXA11 35
  • 91.37 (n)
  • 91.69 (a)
HOXA11 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxa11 35
  • 94.64 (n)
  • 96.14 (a)
Hoxa11 16
Hoxa11 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXA11 35
  • 95.74 (n)
  • 94.89 (a)
HOXA11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100911743 35
  • 94.32 (n)
  • 96.46 (a)
oppossum
(Monodelphis domestica)
Mammalia HOXA11 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA11 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858967 35
  • 81.42 (n)
  • 80.41 (a)
HOXA11 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXA11 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa11 35
  • 76.78 (n)
  • 77.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16037 35
zebrafish
(Danio rerio)
Actinopterygii hoxa11b 35
  • 73.95 (n)
  • 89.66 (a)
hoxa11a 36
  • 67 (a)
OneToMany
hoxa11b 36
  • 73 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7890 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for HOXA11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA11 Gene

ENSEMBL:
Gene Tree for HOXA11 (if available)
TreeFam:
Gene Tree for HOXA11 (if available)

Paralogs for HOXA11 Gene

(9) SIMAP similar genes for HOXA11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXA11: view

Variants for HOXA11 Gene

Sequence variations from dbSNP and Humsavar for HOXA11 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17427861 -- 27,182,790(+) CCGCT(A/G)GAGTC utr-variant-3-prime
rs17501104 -- 27,182,304(+) TCACA(A/T)TGGCT utr-variant-3-prime
rs34878915 -- 27,182,348(+) TCCTA(-/C)CCCTT utr-variant-3-prime
rs3210747 -- 27,182,503(-) TGGTC(C/T)CCAGC utr-variant-3-prime
rs367981250 -- 27,182,802(+) TAGAG(A/G)AGTGG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HOXA11 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7237n71 CNV Loss 21882294
dgv7238n71 CNV Loss 21882294
dgv7239n71 CNV Loss 21882294
nsv5675 CNV Insertion 18451855
nsv887891 CNV Loss 21882294

Variation tolerance for HOXA11 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXA11 Gene

HapMap Linkage Disequilibrium report
HOXA11
Human Gene Mutation Database (HGMD)
HOXA11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA11 Gene

Disorders for HOXA11 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HOXA11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
radioulnar synostosis with amegakaryocytic thrombocytopenia
  • thrombocytopenia, congenital, with radioulnar synostosis
synostosis
radioulnar synostosis
thrombocytopenia
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

HXA11_HUMAN
  • Radioulnar synostosis with amegakaryocytic thrombocytopenia (RSAT) [MIM:605432]: The syndrome consists of an unusual association of bone marrow failure and skeletal defects. Patients have the same skeletal defects, the proximal fusion of the radius and ulna, resulting in extremely limited pronation and supination of the forearm. Some patients have also symptomatic thrombocytopenia, with bruising and bleeding problems since birth, necessitating correction by bone marrow or umbilical-cord stem-cell transplantation. {ECO:0000269 PubMed:11101832}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HOXA11

Genetic Association Database (GAD)
HOXA11
Human Genome Epidemiology (HuGE) Navigator
HOXA11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXA11
genes like me logo Genes that share disorders with HOXA11: view

No data available for Genatlas for HOXA11 Gene

Publications for HOXA11 Gene

  1. Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. (PMID: 19255789) Bouba I. … Georgiou I. (Pediatr. Nephrol. 2009) 3 23 48 67
  2. DNA methylation analysis in liquid-based cytology for cervical cancer screening. (PMID: 19609949) Apostolidou S. … Widschwendter M. (Int. J. Cancer 2009) 3 23
  3. HOXA11 promotes fibroblast proliferation and regulates p53 in uterosacral ligaments. (PMID: 19372592) Connell K.A. … Taylor H.S. (Reprod Sci 2009) 3 23
  4. HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. (PMID: 18274672) Connell K.A. … Taylor H.S. (J. Clin. Invest. 2008) 3 23
  5. Yin Yang 1 physically interacts with Hoxa11 and represses Hoxa11-dependent transcription. (PMID: 16963455) Luke M.P. … Shi Y. (J. Biol. Chem. 2006) 3 23

Products for HOXA11 Gene

Sources for HOXA11 Gene

Content