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Aliases for HOXA10 Gene

Aliases for HOXA10 Gene

  • Homeobox A10 2 3
  • HOX1H 3 4 6
  • Homeobox Protein Hox-1.8 3 4
  • Homeobox Protein Hox-1H 3 4
  • Homeo Box A10 2 3
  • PL 3 4
  • Homeobox Protein Hox-A10 3
  • Homeobox Protein HOXA10 3
  • Homeobox Protein 1H 3
  • HOX1.8 3
  • HOX1 3

External Ids for HOXA10 Gene

Previous Symbols for HOXA10 Gene

  • HOX1H
  • HOX1

Summaries for HOXA10 Gene

Entrez Gene Summary for HOXA10 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for HOXA10 Gene

HOXA10 (Homeobox A10) is a Protein Coding gene. Diseases associated with HOXA10 include ovarian clear cell adenocarcinoma and adenomyosis. Among its related pathways are Transcriptional misregulation in cancer and Signaling events mediated by HDAC Class III. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXA10 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5-AA[AT]TTTTATTAC-3

Gene Wiki entry for HOXA10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA10 Gene

Genomics for HOXA10 Gene

Genomic Location for HOXA10 Gene

Start:
27,170,591 bp from pter
End:
27,180,261 bp from pter
Size:
9,671 bases
Orientation:
Minus strand

Genomic View for HOXA10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXA10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA10 Gene

Regulatory Elements for HOXA10 Gene

Transcription factor binding sites by QIAGEN in the HOXA10 gene promoter:

Proteins for HOXA10 Gene

  • Protein details for HOXA10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31260-HXA10_HUMAN
    Recommended name:
    Homeobox protein Hox-A10
    Protein Accession:
    P31260
    Secondary Accessions:
    • O43370
    • O43605
    • Q15949
    • Q504T1

    Protein attributes for HOXA10 Gene

    Size:
    410 amino acids
    Molecular mass:
    42414 Da
    Quaternary structure:
    • Interacts with SIRT2; the interaction is direct.
    SequenceCaution:
    • Sequence=AAB96917.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH13971.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB86198.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for HOXA10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOXA10 Gene

Proteomics data for HOXA10 Gene at MOPED

Post-translational modifications for HOXA10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXA10 Gene

Domains for HOXA10 Gene

Gene Families for HOXA10 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for HOXA10 Gene

UniProtKB/Swiss-Prot:

HXA10_HUMAN
Domain:
  • Contains 1 homeobox DNA-binding domain.:
    • P31260
Family:
  • Belongs to the Abd-B homeobox family.:
    • P31260
genes like me logo Genes that share domains with HOXA10: view

Function for HOXA10 Gene

Molecular function for HOXA10 Gene

GENATLAS Biochemistry: homeo box A10(1H),homologous to mouse Hox-1.8,expressed in the secretory endometrium
UniProtKB/Swiss-Prot Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5-AA[AT]TTTTATTAC-3

Gene Ontology (GO) - Molecular Function for HOXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 21471217
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 21471217
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 18692240
GO:0042826 histone deacetylase binding IPI 15213244
genes like me logo Genes that share ontologies with HOXA10: view
genes like me logo Genes that share phenotypes with HOXA10: view

Animal Models for HOXA10 Gene

MGI Knock Outs for HOXA10:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXA10 Gene

Localization for HOXA10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA10 Gene COMPARTMENTS Subcellular localization image for HOXA10 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HOXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15213244
GO:0005667 transcription factor complex IEA --
GO:0005737 cytoplasm IDA 15213244
genes like me logo Genes that share ontologies with HOXA10: view

Pathways for HOXA10 Gene

genes like me logo Genes that share pathways with HOXA10: view

Pathways by source for HOXA10 Gene

1 BioSystems pathway for HOXA10 Gene
1 KEGG pathway for HOXA10 Gene

Gene Ontology (GO) - Biological Process for HOXA10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development TAS 8972230
GO:0007283 spermatogenesis IEA --
GO:0007338 single fertilization IEA --
genes like me logo Genes that share ontologies with HOXA10: view

Compounds for HOXA10 Gene

(10) Novoseek inferred chemical compound relationships for HOXA10 Gene

Compound -log(P) Hits PubMed IDs
progesterone 55.5 21
diethylstilbestrol 39.7 7
estradiol 36.7 6
estrogen 33.3 11
prostaglandin 20.3 3
genes like me logo Genes that share compounds with HOXA10: view

Transcripts for HOXA10 Gene

mRNA/cDNA for HOXA10 Gene

(2) REFSEQ mRNAs :
(15) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXA10 Gene

Homeobox A10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA10 Gene

No ASD Table

Relevant External Links for HOXA10 Gene

GeneLoc Exon Structure for
HOXA10
ECgene alternative splicing isoforms for
HOXA10

Expression for HOXA10 Gene

mRNA expression in normal human tissues for HOXA10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA10 Gene

This gene is overexpressed in Uterus (7.7), Muscle - Skeletal (5.7), Colon - Sigmoid (4.2), and Cervix - Endocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOXA10 Gene

SOURCE GeneReport for Unigene cluster for HOXA10 Gene Hs.110637

genes like me logo Genes that share expressions with HOXA10: view

Orthologs for HOXA10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXA10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA10 36
  • 99.51 (n)
  • 99.76 (a)
HOXA10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOXA10 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXA10 36
  • 92.26 (n)
  • 95.11 (a)
HOXA10 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxa10 36
  • 86.16 (n)
  • 88.21 (a)
Hoxa10 16
Hoxa10 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOXA10 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA10 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100909714 36
  • 86.26 (n)
  • 87.65 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 76 (a)
OneToMany
-- 37
  • 76 (a)
OneToMany
HOXA10 36
  • 75.86 (n)
  • 75.49 (a)
lizard
(Anolis carolinensis)
Reptilia HOXA10 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa10 36
  • 69.1 (n)
  • 71.35 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxa10b 36
  • 59.94 (n)
  • 57.49 (a)
hoxa10b 37
  • 50 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
OneToMany
Species with no ortholog for HOXA10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA10 Gene

ENSEMBL:
Gene Tree for HOXA10 (if available)
TreeFam:
Gene Tree for HOXA10 (if available)

Paralogs for HOXA10 Gene

Selected SIMAP similar genes for HOXA10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXA10: view

Variants for HOXA10 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXA10 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7233n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7236n71 CNV Loss 21882294
dgv7237n71 CNV Loss 21882294
dgv7238n71 CNV Loss 21882294
dgv7239n71 CNV Loss 21882294
nsv5675 CNV Insertion 18451855

Relevant External Links for HOXA10 Gene

HapMap Linkage Disequilibrium report
HOXA10
Human Gene Mutation Database (HGMD)
HOXA10

No data available for Sequence variations from dbSNP and Humsavar for HOXA10 Gene

Disorders for HOXA10 Gene

(4) University of Copenhagen DISEASES for HOXA10 Gene

(15) Novoseek inferred disease relationships for HOXA10 Gene

Disease -log(P) Hits PubMed IDs
endometriosis 59.3 33
cryptorchidism 55.5 6
infertility 54.3 11
endometrial carcinoma 53.3 6
t-all 50.7 4

Relevant External Links for HOXA10

Genetic Association Database (GAD)
HOXA10
Human Genome Epidemiology (HuGE) Navigator
HOXA10
genes like me logo Genes that share disorders with HOXA10: view

No data available for UniProtKB/Swiss-Prot for HOXA10 Gene

Publications for HOXA10 Gene

  1. A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells. (PMID: 1676505) Lowney P. … Largman C. (Nucleic Acids Res. 1991) 3 4 23
  2. Homeobox HOXA10 gene analysis in cryptorchidism. (PMID: 14960020) Bertini V. … Simi P. (J. Pediatr. Endocrinol. Metab. 2004) 3 23 49
  3. HOXA10 mutations in congenital absence of uterus and vagina. (PMID: 17482600) Lalwani S. … Gray M.R. (Fertil. Steril. 2008) 3 23 49
  4. Genetic alterations of HOXA10 and their effect on the severity of endometriosis in a Taiwanese population. (PMID: 18339267) Wu H.H. … Tsai H.D. (Reprod. Biomed. Online 2008) 3 23 49
  5. Identification of a HoxA10 activation domain necessary for transcription of the gene encoding beta3 integrin during myeloid differentiation. (PMID: 17439948) Bei L. … Eklund E.A. (J. Biol. Chem. 2007) 3 23

Products for HOXA10 Gene

Sources for HOXA10 Gene

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