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HOXA10 Gene

protein-coding   GIFtS: 58
GCID: GC07M027210

Homeobox A10

(Previous name: homeo box A10)
(Previous symbols: HOX1H, HOX1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homeobox A101 2     PL2 3
HOX1H1 2 3 5     HOX1.82
HOX11 2     Homeobox Protein 1H2
Homeo Box A101 2     Homeobox Protein Hox-A102
Homeobox Protein Hox-1.82 3     Homeobox Protein HOXA102
Homeobox Protein Hox-1H2 3     

External Ids:    HGNC: 51001   Entrez Gene: 32062   Ensembl: ENSG000002532937   OMIM: 1429575   UniProtKB: P312603   

Export aliases for HOXA10 gene to outside databases

Previous GC identifers: GC07M026854 GC07M026918 GC07M026952 GC07M026983 GC07M027176 GC07M027202


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOXA10 Gene:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters
named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally
regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a
DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More
specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment.
Alternatively spliced transcript variants have been described. Read-through transcription also exists between
this gene and the downstream homeobox A9 (HOXA9) gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for HOXA10 Gene:
HOXA10 (homeobox A10) is a protein-coding gene. Diseases associated with HOXA10 include cluttering, and adenomyosis. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is HOXD11.

UniProtKB/Swiss-Prot: HXA10_HUMAN, P31260
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence
5'-AA[AT]TTTTATTAC-3'

Gene Wiki entry for HOXA10 (Homeobox A10) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOXA10 gene promoter:
         p53   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HOXA10 promoter sequence
   Search Chromatin IP Primers for HOXA10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOXA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027210:  view genomic region     (about GC identifiers)

Start:
27,210,210 bp from pter      End:
27,219,880 bp from pter
Size:
9,671 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,261,395-27,271,065     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HXA10_HUMAN, P31260 (See protein sequence)
Recommended Name: Homeobox protein Hox-A10  
Size: 410 amino acids; 42414 Da
Sequence caution: Sequence=AAB96917.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH13971.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB86198.1;
Type=Frameshift; Positions=Several;
Secondary accessions: O43370 O43605 Q15949 Q504T1
Alternative splicing: 2 isoforms:  P31260-1   P31260-2   

Explore the universe of human proteins at neXtProt for HOXA10: NX_P31260

Explore proteomics data for HOXA10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOXA10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061824.3  
    ENSEMBL proteins: 
     ENSP00000283921   ENSP00000379633  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    4 InterPro protein domains:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeobox_dom
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P31260

    ProtoNet protein and cluster: P31260

    UniProtKB/Swiss-Prot: HXA10_HUMAN, P31260
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    HOXA10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HXA10_HUMAN, P31260
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides
    cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence
    5'-AA[AT]TTTTATTAC-3'

         Genatlas biochemistry entry for HOXA10:
    homeo box A10(1H),homologous to mouse Hox-1.8,expressed in the secretory endometrium

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI18692240
    GO:0043565sequence-specific DNA binding IEA--
         
    HOXA10 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOXA10:
     Increased G1 DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Hoxa10):
     digestive/alimentary  endocrine/exocrine gland  growth/size/body  limbs/digits/tail  nervous system 
     reproductive system  skeleton 

    HOXA10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HOXA10: Hoxa10tm1Ipc Hoxa10tm1Mrc Hoxa10tm1Rilm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOXA10
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOXA10

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOXA10
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOXA10

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOXA10:
    hsa-mir-215-5p (MIRT024822), hsa-mir-192-5p (MIRT004850), hsa-mir-204-5p (MIRT000190), hsa-mir-149-5p (MIRT045606), hsa-mir-320a (MIRT044613), hsa-mir-130a-3p (MIRT005441)

    Block miRNA regulation of human, mouse, rat HOXA10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXA10 (see all 41):
    hsa-miR-411* hsa-miR-379* hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-218 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidHOXA10 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOXA10
    Predesigned siRNA for gene silencing in human, mouse, rat HOXA10

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    GenScript: all cDNA clones in your preferred vector: HOXA10 (NM_018951)
    Sino Biological Human cDNA Clone for HOXA10
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOXA10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOXA10

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HXA10_HUMAN, P31260: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--

    HOXA10 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HOXA10 About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    2Signaling events mediated by HDAC Class III
    Signaling events mediated by HDAC Class III

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HOXA10
        Signaling events mediated by HDAC Class III



    1 Kegg Pathway  (Kegg details for HOXA10):
        Transcriptional misregulation in cancer


    HOXA10 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXA10: 
              Stem Cell Transcription Factors in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HOXA10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for HOXA10 (P312601, 2, 3 ENSP000002839214) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPI1P179471, 3, ENSP000002271634EBI-2293516,EBI-2293548 I2D: score=3 STRING: ENSP00000227163
    PTPN11Q061242, 3, ENSP000003409444MINT-8292413 I2D: score=1 STRING: ENSP00000340944
    ENSG00000225987P404253, ENSP000004039484I2D: score=2 STRING: ENSP00000403948
    ENSG00000237344P404253, ENSP000003971774I2D: score=2 STRING: ENSP00000397177
    PBX2P404253, ENSP000003641904I2D: score=2 STRING: ENSP00000364190
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007275multicellular organismal development TAS8972230
    GO:0007283spermatogenesis TAS7700356

    HOXA10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOXA10 (HXA10)

    10 Novoseek inferred chemical compound relationships for HOXA10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 55.5 35 20103740 (6), 11443215 (5), 9525980 (3), 16551735 (2) (see all 9)
    diethylstilbestrol 39.7 10 19299448 (5), 10834931 (1), 15236964 (1)
    estradiol 36.7 7 15044858 (2), 10834931 (1), 12519859 (1), 18456676 (1) (see all 5)
    estrogen 33.3 19 17828513 (3), 9525980 (2), 17311863 (2), 19299448 (1) (see all 7)
    prostaglandin 20.3 3 20022444 (2), 20371740 (1)
    steroid 16.6 2 19854516 (1)
    cycloheximide 2.14 1 9525980 (1)
    oligonucleotide 0 2 10037424 (1), 18456676 (1)
    tyrosine 0 7 12145285 (3), 17138561 (2), 10766757 (1), 15496449 (1)
    testosterone 0 5 12519859 (4), 17702188 (1)



    HOXA10 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOXA10 gene (2 alternative transcripts): 
    NM_018951.3  NM_153715.3  

    Unigene Clusters for HOXA10:

    Homeobox A10
    Hs.110637  [show with all ESTs], Hs.659350  [show with all ESTs]
    Unigene Representative Sequences: NM_018951, NR_037940
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283921(uc011jzm.2 uc003syw.4) ENST00000396344 ENST00000524368
    ENST00000521421 ENST00000519593
    miRNA
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    Block miRNA regulation of human, mouse, rat HOXA10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOXA10 (see all 41):
    hsa-miR-411* hsa-miR-379* hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-218 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidHOXA10 3' UTR sequence
    Inhib. RNA
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    Primer
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    OriGene qPCR primer pairs and template standards for HOXA10
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOXA10
      QuantiTect SYBR Green Assays in human, mouse, rat HOXA10
      QuantiFast Probe-based Assays in human, mouse, rat HOXA10

    Additional mRNA sequence: 

    BC006537.2 BC010023.2 BT006990.1 DQ655931.2 M30599.1 NR_037940.1 S69029.1 U41813.1 
    U82759.1 

    12 DOTS entries:

    DT.100811313  DT.410695  DT.455536  DT.99973937  DT.100742593  DT.91718437  DT.91918370  DT.92428423 
    DT.97861667  DT.95262960  DT.97816450  DT.100811312 

    7 AceView cDNA sequences:

    NM_024014 BC069497 BG749730 BE792613 BP871526 BF820847 BF738660 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOXA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATAAAAGGG
    HOXA10 Expression
    About this image


    HOXA10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 7 entries
             Immature Endochondral Osteoblasts Stylopod Periosteum
     
     Kidney (Urinary System)    fully expand to see all 12 entries
             Ureteric Bud Tip Cells Ureteric Bud
             Metanephros
             mK3
             Metanephric mesenchyme progenitor cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             Lumbar Sclerotome Cells Lumbar Mesenchymal Sclerotome
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Limb Bud Mesenchyme Cells Limb Bud
     
     Somite (Muscoskeletal System)    fully expand to see all 2 entries
             Lumbar Sclerotome Cells Lumbar Mesenchymal Sclerotome
             Lumbar Mesenchymal Sclerotome
    HOXA10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOXA10 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.110637 Hs.659350
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOXA10: 
              Stem Cell Transcription Factors in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for HOXA10
    OriGene qSTAR qPCR primer pairs in human, mouse for HOXA10
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    QuantiTect SYBR Green Assays in human, mouse, rat HOXA10
    QuantiFast Probe-based Assays in human, mouse, rat HOXA10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HOXA10 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoxa101 , 5 homeobox A101, 5 86.16(n)1
    88.21(a)1
      6 (25.40 cM)5
    153951  NM_008263.31  NP_032289.21 
     522311975 
    chicken
    (Gallus gallus)
    Aves HOXA101 homeobox A10 75.86(n)
    75.49(a)
      776143  XM_001235692.3  XP_001235693.2 
    lizard
    (Anolis carolinensis)
    Reptilia HOXA106
    homeobox A10
    64(a)
    1 ↔ 1
    GL343275.1(1422825-1428549)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia hoxa101 homeobox A10 69.1(n)
    71.35(a)
      100485262  XM_002933394.2  XP_002933440.2 
    zebrafish
    (Danio rerio)
    Actinopterygii hoxa10b1 homeo box A10b 59.94(n)
    57.49(a)
      30391  NM_131155.1  NP_571230.1 


    ENSEMBL Gene Tree for HOXA10 (if available)
    TreeFam Gene Tree for HOXA10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOXA10 gene
    HOXD112  ENSG000002571842  HOXD102  HOXC132  HOXC102  HOXD122  HOXA92  HOXA132  
    HOXC92  HOXB132  HOXC122  HOXC112  HOXD132  HOXA112  HOXB92  HOXD92  
    14 SIMAP similar genes for HOXA10 using alignment to 2 protein entries:     HXA10_HUMAN (see all proteins):
    HOX B6    HOXC13    HOXA4    HOXB1    CDX1    NKX2-5
    HOXD8    HOXB9    HOXA9    HOXD11    HOXD10    HOXA-9
    HOXC10    HOXA11

    HOXA10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HOXA10 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5675CNV Insertion18451855
    nsv887856CNV Loss21882294
    dgv7239n71CNV Loss21882294
    dgv7233n71CNV Loss21882294
    dgv7237n71CNV Loss21882294
    dgv7231n71CNV Loss21882294
    dgv7236n71CNV Loss21882294
    dgv7234n71CNV Loss21882294
    dgv7238n71CNV Loss21882294
    nsv824042CNV Gain20364138

    Human Gene Mutation Database (HGMD): HOXA10
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 142957    OMIM disorders: --

    Selected diseases for HOXA10 (see all 35):    
    About MalaCards
    cluttering    adenomyosis    endometritis    cryptorchidism
    thrombocytopenia-absent radius syndrome    ectopic pregnancy    pregnancy loss    endometrial carcinoma
    clubfoot    endometrial adenocarcinoma    endometriosis    ovarian clear cell adenocarcinoma
    acute lymphocytic leukemia    thrombocytopenia    acute myeloid leukemia    myeloid leukemia
    clear cell adenocarcinoma    chronic myeloid leukemia    dental caries    uterine fibroid

    4 diseases from the University of Copenhagen DISEASES database for HOXA10:
    Endometriosis     Cryptorchidism     Infertility     Leukemia

    HOXA10 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for HOXA10 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometriosis 59.3 45 19736237 (6), 18829447 (4), 16647375 (4), 17350963 (4) (see all 10)
    cryptorchidism 55.5 6 10037424 (3), 14960020 (3)
    infertility 54.3 12 19736237 (5), 11953062 (4), 9525980 (1), 10981664 (1)
    endometrial carcinoma 53.3 7 15627890 (4), 11875117 (1), 12489992 (1)
    t-all 50.7 6 17039236 (2), 15674412 (1), 12637319 (1)
    leukemogenesis 46.9 1 11290589 (1)
    pregnancy loss 37.7 1 19389728 (1)
    myeloid leukemia 33.9 1 10766757 (1)
    leukemia 33.7 5 20022444 (2), 11314021 (1), 19155294 (1), 11070089 (1)
    blast crisis 32.4 3 17361218 (1), 7556525 (1)

    Genetic Association Database (GAD): HOXA10
    Human Genome Epidemiology (HuGE) Navigator: HOXA10 (8 documents)

    Export disorders for HOXA10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOXA10 gene, integrated from 10 sources (see all 180):
    (articles sorted by number of sources associating them with HOXA10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HOXA10 mutations in congenital absence of uterus and vagina. (PubMed id 17482600)1, 4, 9 Lalwani S....Gray M.R. (Fertil. Steril. 2008)
    2. Genetic alterations of HOXA10 and their effect on the severity of endometriosis in a Taiwanese population. (PubMed id 18339267)1, 4, 9 Wu H.H....Tsai H.D. (Reprod. Biomed. Online 2008)
    3. Homeobox HOXA10 gene analysis in cryptorchidism. (PubMed id 14960020)1, 4, 9 Bertini V....Simi P. (amp 2004)
    4. Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. (PubMed id 7906121)1, 2, 9 Castronovo V.... Sobel M. (Biochem. Pharmacol. 1994)
    5. A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells. (PubMed id 1676505)1, 2, 9 Lowney P.... Largman C. (Nucleic Acids Res. 1991)
    6. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    7. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. (PubMed id 19938081)1, 4 Ester A.R....Hecht J.T. (Am. J. Med. Genet. A 2009)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (Cell 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3206 HGNC: 5100 AceView: HOXA6 Ensembl:ENSG00000253293 euGenes: HUgn3206
    ECgene: HOXA10 Kegg: 3206 H-InvDB: HOXA10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOXA10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HOXA10 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOXA10 gene:
    Search GeneIP for patents involving HOXA10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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