Aliases for HOXA10 Gene
External Ids for HOXA10 Gene
Previous HGNC Symbols for HOXA10 Gene
Previous GeneCards Identifiers for HOXA10 Gene
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]
GeneCards Summary for HOXA10 Gene
HOXA10 (Homeobox A10) is a Protein Coding gene. Diseases associated with HOXA10 include Clivus Chordoma and Endometriosis. Among its related pathways are Signaling events mediated by HDAC Class III and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding and histone deacetylase binding. An important paralog of this gene is HOXD10.
UniProtKB/Swiss-Prot for HOXA10 Gene
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5-AA[AT]TTTTATTAC-3.