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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOXA10 Gene

protein-coding   GIFtS: 59
GCID: GC07M027210

homeobox A10

(Previous name: homeo box A10 )
(Previous symbols: HOX1H, HOX1)
 Explore 33 diseases affiliated with
HOXA10 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOXA10    

Aliases
for HOXA10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homeobox A101 2     PL2 3
HOX1H1 2 3 5     HOX1.82
HOX11 2     Homeobox Protein 1H2
Homeo Box A101 2     Homeobox Protein Hox-A102
Homeobox Protein Hox-1.82 3     Homeobox Protein HOXA102
Homeobox Protein Hox-1H2 3     

External Ids:    HGNC: 51001   Entrez Gene: 32062   Ensembl: ENSG000002532937   OMIM: 1429575   UniProtKB: P312603   

Export aliases for HOXA10 gene to outside databases

Previous GC identifers: GC07M026854 GC07M026918 GC07M026952 GC07M026983 GC07M027176 GC07M027202


Summaries
for HOXA10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOXA10:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named
A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during
embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription
factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in
fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript
variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9
(HOXA9) gene. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: HXA10_HUMAN, P31260
Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'

Gene Wiki entry for HOXA10 (Homeobox A10)


Genomic Views
for HOXA10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOXA10 gene promoter:
         p53   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): HOXA10 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOXA10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOXA10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.2   Ensembl cytogenetic band:  7p15.2   HGNC cytogenetic band: 7p15.2

HOXA10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOXA10 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M027210:  view genomic region     (about GC identifiers)

Start:
 27,210,210 bp from pter      End:
 27,219,880 bp from pter
Size:
 9,671 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 27,261,395-27,271,061     

Proteins
for HOXA10 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HXA10_HUMAN, P31260 (See protein sequence)
Recommended Name: Homeobox protein Hox-A10  
Size: 410 amino acids; 42414 Da
Subcellular location: Nucleus
Sequence caution: Sequence=AAB96917.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH13971.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB86198.1;
Type=Frameshift; Positions=Several;
Secondary accessions: O43370 O43605 Q15949 Q504T1
Alternative splicing: 2 isoforms:  P31260-1   P31260-2   

Explore the universe of human proteins at neXtProt for HOXA10: NX_P31260

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P31260

    • HOXA10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061824.3  
    ENSEMBL proteins: 
     ENSP00000283921   ENSP00000379633  

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    Novus Biologicals HOXA10 Lysate
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    Uscn Proteins for HOXA10

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005667transcription factor complex IEA--


    HOXA10 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HOXA10

    Protein Domains /
    Families
    for HOXA10 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOXA10 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020479 Homeobox_metazoa
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P31260

    ProtoNet protein and cluster: P31260

    UniProtKB/Swiss-Prot: HXA10_HUMAN, P31260
    Similarity: Belongs to the Abd-B homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for HOXA10 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HXA10_HUMAN, P31260
    Function: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells
    with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'

         Genatlas biochemistry entry for HOXA10:
    homeo box A10(1H),homologous to mouse Hox-1.8,expressed in the secretory endometrium

    miRNA
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    hsa-mir-192 (MIRT004850), hsa-mir-204 (MIRT000190), hsa-mir-130a (MIRT005441)

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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXA10
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA10 (see all 41):
    hsa-miR-411* hsa-miR-379* hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-218 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: HOXA10 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: HOXA10
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA10 (see all 4)
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    Cell Line
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    Search LifeMap BioReagents cell lines for HOXA10

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI18692240
    GO:0043565sequence-specific DNA binding IEA--


    HOXA10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HOXA10:
     Increased G1 DNA content 

    Animal Models:
         Mouse knock-outs for HOXA10: Hoxa10tm1Ipc Hoxa10tm1Mrc Hoxa10tm1Rilm
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Hoxa10):
     digestive/alimentary  endocrine/exocrine gland  growth/size  limbs/digits/tail  nervous system 
     reproductive system  skeleton 

    HOXA10 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOXA10 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling events mediated by HDAC Class III
    		Signaling events mediated by HDAC Class III1.00


    1 BioSystems Pathway for HOXA10 
        Signaling events mediated by HDAC Class III


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOXA10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/18 Interacting proteins for HOXA10 (P312601, 2, 3 ENSP000002839214) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPI1P179471, 3, ENSP000002271634EBI-2293516,EBI-2293548 I2D: score=3 STRING: ENSP00000227163
    PTPN11Q061242, 3, ENSP000003409444MINT-8292413 I2D: score=1 STRING: ENSP00000340944
    MEIS1O004703, ENSP000002723694I2D: score=3 STRING: ENSP00000272369
    CREBBPQ927933, ENSP000002623674I2D: score=2 STRING: ENSP00000262367
    PTPN6P293503, ENSP000003915924I2D: score=2 STRING: ENSP00000391592
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0007275multicellular organismal development TAS8972230
    GO:0007283spermatogenesis TAS7700356
    GO:0009952anterior/posterior pattern specification IEA--


    HOXA10 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOXA10 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HOXA10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOXA10
    10 Novoseek chemical compound relationships for HOXA10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 55.5 35 20103740 (6), 11443215 (5), 9525980 (3), 16551735 (2) (see all 9)
    diethylstilbestrol 39.7 10 19299448 (5), 10834931 (1), 15236964 (1)
    estradiol 36.7 7 15044858 (2), 10834931 (1), 12519859 (1), 18456676 (1) (see all 5)
    estrogen 33.3 19 17828513 (3), 9525980 (2), 17311863 (2), 19299448 (1) (see all 7)
    prostaglandin 20.3 3 20022444 (2), 20371740 (1)
    steroid 16.6 2 19854516 (1)
    cycloheximide 2.14 1 9525980 (1)
    oligonucleotide 0 2 10037424 (1), 18456676 (1)
    tyrosine 0 7 12145285 (3), 17138561 (2), 10766757 (1), 15496449 (1)
    testosterone 0 5 12519859 (4), 17702188 (1)

    Search CenterWatch for drugs/clinical trials and news about HOXA10 / HXA10 

    Transcripts
    for HOXA10 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOXA10 gene (2 alternative transcripts): 
    NM_018951.3  NM_153715.3  

    Unigene Clusters for HOXA10:

    Homeobox A10
    Hs.110637  [show with all ESTs], Hs.659350  [show with all ESTs]
    Unigene Representative Sequences: NM_018951, NR_037940
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283921(uc011jzm.2 uc003syw.4) ENST00000396344 ENST00000524368
    ENST00000521421 ENST00000519593

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOXA10
    8/41 QIAGEN miScript miRNA Assays for microRNAs that regulate HOXA10 (see all 41):
    hsa-miR-411* hsa-miR-379* hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-374a hsa-miR-218 hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: HOXA10 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOXA10 (see all 4)
    OriGene shRNA RFP: HOXA10
    OriGene siRNA: HOXA10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOXA10
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOXA10 (see all 4)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HOXA10 (NM_018951)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOXA10
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    Additional cDNA sequence: 

    BC006537.2 BC010023.2 BT006990.1 DQ655931.2 M30599.1 NR_037940.1 S69029.1 U41813.1 
    U82759.1 

    13 DOTS entries:

    DT.100811313  DT.455536  DT.410695  DT.99973937  DT.97861667  DT.100742593  DT.91718437  DT.91918370 
    DT.100811312  DT.92428423  DT.75100624  DT.95262960  DT.97816450 

    7 AceView cDNA sequences:

    NM_024014 BC069497 BG749730 BP871526 BE792613 BF738660 BF820847 

    GeneLoc Exon Structure


    Expression
    for HOXA10 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOXA10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CATAAAAGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOXA10 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/25 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 25) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneAutopod PeriosteumImmature Endochondral OsteoblastsBone
    BoneStylopod PeriosteumImmature Endochondral OsteoblastsBone
    BoneThoracic VertebraeImmature Endochondral OsteoblastsBone
    BoneZeugopod PeriosteumImmature Endochondral OsteoblastsBone
    LimbLimb BudLimb Bud Mesenchyme CellsMesoderm
    LimbStylopodPrechondrocytic Mesenchymal CellsBone, Cartilage
    SomiteLumbar Mesenchymal SclerotomeLumbar Sclerotome CellsBone, Cartilage, Tendons & Ligaments
    BoneCervical VertebraeImmature Endochondral OsteoblastsBone
    BoneLumbar VertebraeImmature Endochondral OsteoblastsBone
    BoneSacral VertebraeImmature Endochondral OsteoblastsBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    mK3 (Cell line)Kidney
    mK4 (Cell line)Kidney
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    CD31, CD144 positive cells (Two-step protocol fo...)

    See HOXA10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOXA10

    SOURCE GeneReport for Unigene clusters: Hs.110637 Hs.659350
        SABiosciences Expression via Pathway-Focused PCR Arrays including HOXA10: 
              Stem Cell Transcription Factors in human mouse rat
              Polycomb & Trithorax Target Genes in human mouse rat
              T Helper Cell Differentiation in human mouse rat
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOXA10

    Orthologs
    for HOXA10 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOXA10 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOXA101 homeobox A10 78.09(n)
    77.72(a)    		   776143  XM_001235692.2  XP_001235693.2 
    lizard
    (Anolis carolinensis)    		 Reptilia HOXA106
    HOXD96
    		 --
    		 61(a)
    19(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343275.1(1423152-1426968)
    GL343356.1(518262-536480)
    zebrafish
    (Danio rerio)    		 Actinopterygii hoxa10b1 homeo box A10b 60.98(n)
    60.06(a)    		   30391  NM_131155.1  NP_571230.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea nob-16
    		 kNOB-like posterior (NO Backside) family member (n...
    		 18(a)
    		 1 → many
    		 III(12077688-12084220)


    ENSEMBL Gene Tree for HOXA10 (if available)
    TreeFam Gene Tree for HOXA10 (if available) 

    Paralogs
    for HOXA10 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOXA10 gene
    HOXA92  HOXA132  HOXC92  HOXD112  HOXC122  HOXB132  ENSG000002571842  HOXC112  
    HOXD102  HOXD132  HOXC132  HOXA112  HOXB92  HOXC102  HOXD122  HOXD92  
    16 SIMAP similar genes for HOXA10 using alignment to 2 protein entries:     HXA10_HUMAN (see all proteins):
    HOX B6    HOXC13    HOXA4    HOXB1    CDX1    NKX2-5
    HOXD8    HOXB9    HOXA9    HOXD11    MEOX1    HOXD10
    HOXA-9    HOXC10    HOXA11    HOXC9

    HOXA10 for paralogs           About GeneDecksing



    Genomic Variants
    for HOXA10 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/186 NCBI SNPs in HOXA10 are shown (see all 186)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs353859921,2
    		C--27209769(+) GGGGGG/AGGCCC 5 -- int1 ds5001 us2k12Minor allele frequency- A:0.25NA 4
    rs1838739711,2
    		--27209878(+) GTGACC/TCAGAC 5 -- us2k1 ds5001 int10--------
    rs174722031,2
    		C,F,H,--27210179(+) AAAGTG/AGAAGG 5 -- us2k1 ds5001 int19Minor allele frequency- A:0.19NS NA CSA WA 1014
    rs1874925871,2
    		--27210353(+) AATAAC/TGATAG 5 -- int1 ut31 us2k1 nc-transcript-variant0--------
    rs360750451,2
    		C,--27210428(+) TTATAG/-GTTTT 5 -- int1 us2k1 ut31 nc-transcript-variant1Minor allele frequency- -:0.00CSA 2
    rs581730831,2
    		C--27210429(+) TATAGG/-TTTTT 5 -- int1 us2k1 ut31 nc-transcript-variant1Minor allele frequency- -:0.00NA 2
    rs792136201,2
    		C,--27210430(+) TATAGG/TTTTTT 5 -- int1 us2k1 ut31 nc-transcript-variant0--------
    rs1920113511,2
    		--27210507(+) ACAATA/GTCTCC 5 -- us2k1 ut31 int1 nc-transcript-variant0--------
    rs343118131,2
    		C,--27210578(+) CAAAC-/AAAAAA 5 -- int1 nc-transcript-variantut31 us2k11Minor allele frequency- A:0.50NA 2
    rs709946321,2
    		C--27210582(+) AAAAAA/-CTTTT 5 -- us2k1 ut31 int1 nc-transcript-variant1Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for HOXA10 (27210210 - 27219880 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for HOXA10: --
    Human Gene Mutation Database (HGMD): HOXA10

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for HOXA10 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOXA10 for disorders           About GeneDecksing

    OMIM gene information: 142957    OMIM disorders: --

    20/33 diseases for HOXA10 (see all 33):    About MalaCards
    thrombocytopenia-absent radius syndrome    ectopic pregnancy    myeloid leukemia    polycystic ovary syndrome
    cluttering    oral squamous cell carcinoma    cryptorchidism    squamous cell carcinoma
    acute lymphoblastic leukemia    acute lymphocytic leukemia    acute myeloid leukemia    lymphoblastic leukemia
    chronic myeloid leukemia    lymphocytic leukemia    leukemia    endometrial carcinoma
    endometritis    thrombocytopenia    clubfoot    adenomyosis

    4 diseases from the University of Copenhagen DISEASES database for HOXA10:
    Endometriosis     Cryptorchidism     Infertility     Leukemia

    10/15 Novoseek disease relationships for HOXA10 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometriosis 59.3 45 19736237 (6), 18829447 (4), 16647375 (4), 17350963 (4) (see all 10)
    cryptorchidism 55.5 6 10037424 (3), 14960020 (3)
    infertility 54.3 12 19736237 (5), 11953062 (4), 9525980 (1), 10981664 (1)
    endometrial carcinoma 53.3 7 15627890 (4), 11875117 (1), 12489992 (1)
    t-all 50.7 6 17039236 (2), 15674412 (1), 12637319 (1)
    leukemogenesis 46.9 1 11290589 (1)
    pregnancy loss 37.7 1 19389728 (1)
    myeloid leukemia 33.9 1 10766757 (1)
    leukemia 33.7 5 20022444 (2), 11314021 (1), 19155294 (1), 11070089 (1)
    blast crisis 32.4 3 17361218 (1), 7556525 (1)

    Genetic Association Database (GAD): HOXA10
    Human Genome Epidemiology (HuGE) Navigator: HOXA10 (8 documents)

    Export disorders for HOXA10 gene to outside databases

    Publications
    for HOXA10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOXA10 gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with HOXA10)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Homeobox HOXA10 gene analysis in cryptorchidism. (PubMed id 14960020)1, 4, 9 Bertini V....Simi P. (2004)
    2. Homeobox genes: potential candidates for the transcriptional control of the transformed and invasive phenotype. (PubMed id 7906121)1, 2, 9 Castronovo V.... Sobel M. (1994)
    3. A human Hox 1 homeobox gene exhibits myeloid-specific expression of alternative transcripts in human hematopoietic cells. (PubMed id 1676505)1, 2, 9 Lowney P.... Largman C. (1991)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Vertebrate homeobox gene nomenclature. (PubMed id 1358459)1, 3 Scott M.P. (1992)
    7. Nomenclature for human homeobox genes. (PubMed id 1973146)1, 3 McAlpine P.J. and Shows T.B. (1990)
    8. Lineage-restricted expression of homeobox-containing genes in human hematopoietic cell lines. (PubMed id 2573064)1, 2 Shen W.-F.... Lawrence H.J. (1989)
    9. The human HOX gene family. (PubMed id 2574852)1, 2 Acampora D.... Boncinelli E. (1989)
    10. Salpingectomy increases peri-implantation endometrial HOXA10 expression in women with hydrosalpinx. (PubMed id 17173899)1, 9 Daftary G.S....Taylor H.S. (2007)

    External Searches for HOXA10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing HOXA10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3206 HGNC: 5100 AceView: HOXA6 Ensembl:ENSG00000253293 euGenes: HUgn3206
    ECgene: HOXA10 H-InvDB: HOXA10

    Other Databases showing HOXA10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOXA10 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOXA10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HOXA10 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HOXA10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOXA10 gene:
    Search GeneIP for patents involving HOXA10

    GeneCards and IP:
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