TLX1 Gene
protein-coding GIFtS: 54
GC10P102880
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T-cell leukemia homeobox 1 (Previous names: homeo box 11 (T-cell lymphoma 3-associated breakpoint), T-cell leukemia, homeobox 1 ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: TCL3, HOX11)
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Aliases & Descriptions for TLX1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
|---|
| HOX11 2, 3, 5 | | MGC163402 2 | | OTTHUMP00000020816 2 | | TCL3 2, 3, 5 |
| | | Descriptions |
|---|
Homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch) 2 | | Homeobox protein Hox-11 3 | | Proto-oncogene TCL-3 3 | | T-cell leukemia homeobox 1 2 | | T-cell leukemia, homeobox 1 1, 2 | | T-cell leukemia/lymphoma protein 3 3 | | homeo box 11 (T-cell lymphoma 3-associated breakpoint) 1, 2 |
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| | Search outside databases for aliases for TLX1 genePrevious GC identifers: GC10P101783 GC10P102123 GC10P103021 GC10P102554 |
Summaries for TLX1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'Gene Wiki entry for TLX1 |
Genomic Location for TLX1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TLX1 gene 
Entrez Gene cytogenetic band: 10q24 Ensembl cytogenetic band: 10q24.31 HGNC cytogenetic band: 10q24.32TLX1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P102880:
(about GC identifiers)
Start:
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102,880,252 bp from pter |
End:
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102,887,536 bp from pter |
Size:
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7,285 bases |
Orientation:
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plus strand |
RefSeq DNA sequence:- NC_000010.9 NT_030059.12
| Proteins for TLX1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314 (See
protein sequence)Recommended Name: T-cell leukemia homeobox protein 1 Size: 330 amino acids; 34365 Da
Subcellular location: Nucleus (Probable)
Miscellaneous: TLX1 is oriented in a head-to-head manner with TDI. Both genes share the same promoter with robust bidirectional activity
Secondary accessions: O75699 Q5VXP2 Q9HCA0REFSEQ proteins: NP_005512.1
ENSEMBL proteins: ENSP00000359215
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TLX1 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for TLX1: Assays for TLX1: | Protein
Domains/ Families for TLX1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P31314
ProtoNet protein and cluster: P31314 1 Blocks protein family: IPB000747 'Homeobox' engrailed-type protein
UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314Similarity: Contains 1 homeobox DNA-binding domain | Gene Function for TLX1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005521
Applied Biosystems Silencer® siRNAs for TLX1
Sigma-Aldrich siRNA for TLX1  Sigma-Aldrich shRNA for TLX1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005521                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005521                                  untagged cDNA clone in CMV expression vector: NM_005521 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005521
UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314Function: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tlx1):
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | | GO:0046982 | protein heterodimerization activity |
IEA | -- | About this table | Pathways & Interactions for TLX1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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Gene Network CentralTM Interacting Genes and Proteins Network for TLX1 
5/23 Interacting proteins for TLX1 (ENSP000003592153) via UniProtKB, MINT, and/or STRING (see all 23
)About this table
5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0007417 | central nervous system development |
IEA | -- | | GO:0008284 | positive regulation of cell proliferation |
IEA | -- | | GO:0030182 | neuron differentiation |
IEA | -- | About this table
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Drugs & Compounds for TLX1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for TLX1 5 Novoseek chemical compound relationships for TLX1 gene
About this table
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Transcripts for TLX1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005521
Sigma-Aldrich siRNA for TLX1  Sigma-Aldrich shRNA for TLX1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005521 REFSEQ mRNAs for TLX1 gene: NM_005521.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005521               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005521                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005521                                  untagged cDNA clone in CMV expression vector: NM_005521  Additional cDNA sequence: BC130530.1 M62626.1 M75952.1 S38742.1 2 DOTS entries: DT.108199 DT.121300709 16 AceView cDNA sequences:BF514683 M75952 BI837519 CB185049 BX108942 AW149660 S38742 AW149389 AA007444 D57678 AA007490 BF513502 BV197636 NM_005521 AI346822 AA922708
highest scoring ESTs for TLX1:S38742 AA007444 AA007490 AW814964 BF514683 BX108942 M75952 AA922708 AI346822 AW149660 Unigene Cluster for TLX1: T-cell leukemia homeobox 1 Hs.89583 [show with all ESTs]Unigene Representative Sequence: M62626
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TLX1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | |
| SP1: | |   | |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TLX1
1 Ensembl transcript including schematic representation: ENST00000370196
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Expression for TLX1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TLX1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TLX1
1 / 2 / 3 3 probe-sets matching TLX1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.89583
Expression variation in blood from EXPOLDB for TLX1 |
Orthologs for TLX1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for TLX1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for TLX1
ENSEMBL Gene Tree for TLX1 | Paralogs for TLX1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TLX1 gene
- TLX32 TLX22
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SNPs/Variants for TLX1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for TLX1 (up to first 250kb)
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Disorders & Mutations for TLX1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 186770 UniProtKB/Swiss-Prot: TLX1_HUMAN, P31314
A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD8 Novoseek disease relationships for TLX1 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| t-all |
92.47 |
47 |
15384172 (3), 1717256 (2), 12750702 (2), 7478554 (2) (see all 26) |
| leukemogenesis |
73.56 |
6 |
11587205 (1), 8559142 (1), 15384172 (1), 17303350 (1) (see all 6) |
| leukemia t-cell |
71.95 |
10 |
1352396 (2), 7698766 (1), 1717256 (1), 8559142 (1) (see all 7) |
| leukemia |
52.09 |
22 |
14659882 (3), 14975618 (3), 10393251 (2), 9778044 (2) (see all 12) |
| lymphoblastic leukemia acute childhood |
40.15 |
1 |
7478554 (1) |
| cancer |
0.00 |
4 |
12750702 (2), 14659882 (1), 7719228 (1) |
| tumors |
0.00 |
8 |
11069299 (3), 7478554 (2), 18082256 (1), 9811890 (1) |
| lymphoma |
0.00 |
4 |
11069299 (3) |
About this table
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Medical News for TLX1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TLX1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/78 PubMed articles for TLX1 gene (see all 78
):- Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. (PubMed id 1676542)2, 3, 4 Hatano M.... Korsmeyer S.J. (1991)
- Multiple negative elements contribute to repression of the HOX11 proto-oncogene. (PubMed id 9778044)1, 3, 4 Brake R.L.... Watt P.M. (1998)
- Genomic organization of the putative human homeobox proto-oncogene HOX-11 (TCL-3) and its endogenous expression in T cells. (PubMed id 1352396)1, 3, 4 Lu M.... Ho A.D. (1992)
- Sequence of 10q24 locus surrounding the HOX11 oncogene reveals a new gene HUG1 expressed in a T-ALL cell line. (PubMed id 10393251)1, 3, 4 Watt P.M.... Kees U.R. (1999)
- The tcl-3 proto-oncogene altered by chromosomal translocation in T- cell leukemia codes for a homeobox protein. (PubMed id 1717256)1, 3, 4 Lu M.... Ho A.D. (1991)
- HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24. (PubMed id 1681546)1, 3, 4 Kennedy M.A.... Rabbitts T.H. (1991)
- Nomenclature for human homeobox genes. (PubMed id 1973146)2, 3 McAlpine P.J. and Shows T.B. (1990)
- HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. (PubMed id 9009195)1, 3 Kawabe T....Korsmeyer S.J. (1997)
- A microarray model system identifies potential new target genes of the proto-oncogene HOX11. (PubMed id 15384172)1, 3 Hoffmann K....Kees U.R. (2004)
- The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells. (PubMed id 16357834)1, 3 Heidari M....Greene W.K. (2006)
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Search for TLX1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing TLX1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TLX1
(According to HUGE)
About This Section
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Specialized Databases showing TLX1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| About This Section
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| Services for TLX1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for TLX1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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