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HOTS Gene(Protein Coding)

H19 Opposite Tumor Suppressor

GCID:
GC11P000050
GIFtS:
8
Genes Participants
UDN Logo

Aliases for HOTS Gene

Aliases for HOTS Gene

  • H19 Opposite Tumor Suppressor 3

External Ids for HOTS Gene

Previous GeneCards Identifiers for HOTS Gene

  • GC11U902643

Summaries for HOTS Gene

Entrez Gene Summary for HOTS Gene

  • This gene encodes a protein that localizes to the nucleus and interacts with enhancer of rudimentary homolog protein. Overexpression of this protein can inhibit tumor growth. This gene is transcribed in antisense to the H19 non-coding transcript and is imprinted and maternally expressed. [provided by RefSeq, Nov 2015]

GeneCards Summary for HOTS Gene

HOTS (H19 Opposite Tumor Suppressor) is a Protein Coding gene.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOTS Gene

Genomics for HOTS Gene

Products:

  1. Regulatory Element

Genomic Location for HOTS Gene

Chromosome:
11
Start:
50,359 bp from pter
End:
50,842 bp from pter
Size:
484 bases
Orientation:
Plus strand

Genomic View for HOTS Gene

Genes around HOTS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOTS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOTS Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HOTS Gene

No data available for Regulatory Elements for HOTS Gene

Proteins for HOTS Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for HOTS Gene

No Post-translational modifications

Other Protein References for HOTS Gene

REFSEQ proteins:

No data available for DME Specific Peptides for HOTS Gene

Domains & Families for HOTS Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HOTS Gene

Function for HOTS Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HOTS Gene

Localization for HOTS Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HOTS Gene

Pathways & Interactions for HOTS Gene

SuperPathways for HOTS Gene

PathCards logo More details on SuperPathways for HOTS
No Data Available

Interacting Proteins for HOTS Gene

Gene Ontology (GO) - Biological Process for HOTS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HOTS Gene

Drugs & Compounds for HOTS Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HOTS Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HOTS Gene

(1) REFSEQ mRNAs :

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOTS Gene

No ASD Table

Relevant External Links for HOTS Gene

GeneLoc Exon Structure for
HOTS

Expression for HOTS Gene

Products:

  1. Primer
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOTS Gene

Orthologs for HOTS Gene

No data available for Orthologs and Evolution for HOTS Gene

Paralogs for HOTS Gene

No data available for Paralogs for HOTS Gene

Variants for HOTS Gene

Sequence variations from dbSNP and Humsavar for HOTS Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000877876 -- 1,992,011(+) TCCCT(G/T)CCTGA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1001383248 -- 1,996,221(+) GTGAG(A/G)TGGTG intron-variant, utr-variant-3-prime
rs1002821160 -- 1,993,929(+) TGTCC(C/T)TGGAA intron-variant, downstream-variant-500B, utr-variant-5-prime
rs1004948110 -- 1,993,605(+) TATCT(C/T)CTGAG intron-variant, downstream-variant-500B, utr-variant-5-prime
rs1005407237 -- 1,993,895(+) GGTGA(C/T)CACCC intron-variant, downstream-variant-500B, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HOTS Gene

Variant ID Type Subtype PubMed ID
dgv1015n100 CNV gain 25217958
dgv1016n100 CNV gain 25217958
esv29980 CNV loss 17803354
nsv1047474 CNV gain 25217958
nsv467645 CNV gain 19166990
nsv469926 CNV loss 18288195
nsv522320 CNV loss 19592680
nsv553047 CNV gain 21841781
nsv553064 CNV loss 21841781
nsv951283 CNV deletion 24416366

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for HOTS Gene

Disorders for HOTS Gene

Relevant External Links for HOTS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOTS

No disorders were found for HOTS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOTS Gene

Publications for HOTS Gene

  1. A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor encoded by a human imprinted H19 antisense transcript. (PMID: 21940503) Onyango P. … Feinberg A.P. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 64
  2. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for HOTS Gene

Sources for HOTS Gene

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