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HOTAIRM1 Gene(RNA Gene)

HOXA Transcript Antisense RNA, Myeloid-Specific 1

GCID:
GC07P027095
GIFtS:
21
Genes Participants
UDN Logo

Aliases for HOTAIRM1 Gene

Subcategory (RNA class) for HOTAIRM1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for HOTAIRM1 Gene

  • HOXA Transcript Antisense RNA, Myeloid-Specific 1 2 3 5
  • HOXA Transcript Antisense RNA, Myeloid-Specific 1 (Non-Protein Coding) 2 3
  • HOXA Cluster Antisense RNA 1 (Non-Protein Coding) 2 3
  • Hox Transcript Antisense RNA, Myeloid-Specific 1 (Non-Protein Coding) 2
  • HOX Antisense Intergenic RNA Myeloid 1 3
  • Non-Protein Coding RNA 179 2
  • NCRNA00179 3
  • HOXA1-AS1 3
  • HOXA-AS1 3

External Ids for HOTAIRM1 Gene

Previous GeneCards Identifiers for HOTAIRM1 Gene

  • GC00U924339
  • GC07P027137

Summaries for HOTAIRM1 Gene

Entrez Gene Summary for HOTAIRM1 Gene

  • This non-coding locus is located in the HOX gene cluster. Transcription of this locus is induced by retinoic acid, and transcripts likely function in regulation of myelopoiesis through transcriptional activation of several genes in the HOXA cluster, in addition to several beta-2 integrins. [provided by RefSeq, Jan 2013]

GeneCards Summary for HOTAIRM1 Gene

HOTAIRM1 (HOXA Transcript Antisense RNA, Myeloid-Specific 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOTAIRM1 Gene

Genomics for HOTAIRM1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for HOTAIRM1 Gene

Enhancers for HOTAIRM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G027095 3.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 43.5 +42.5 42549 86.3 MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 HOTAIRM1 HOXA10-AS HOXA2 HOXA-AS2 HOXA9 HOXA11-AS HOXA10 HOXA11 EIF4HP1 SKAP2
GH07G027030 1.2 Ensembl ENCODE 54.9 -64.1 -64130 2.0 HDAC1 ATF1 PKNOX1 TBL1XR1 FEZF1 TCF12 ZNF766 GATA2 ELK1 ZBTB11 HOTAIRM1 SKAP2 HOXA1 HOXA2 HOXA-AS2 HOXA3 TPM3P4 NHP2P2
GH07G026855 1.4 Ensembl ENCODE dbSUPER 36.8 -238.1 -238100 4.8 HDAC1 PKNOX1 NFIB FEZF1 ZBTB40 TCF12 GLIS2 GATA2 EGR1 ZNF366 HOTAIRM1 HOXA5 HOXA-AS3 HOXA4 HOXA3 HOXA6 HOXA1 HOXA2 HOXA-AS2 SKAP2
GH07G026862 1.4 ENCODE dbSUPER 22.1 -231.5 -231533 3.1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 HOTAIRM1 HOXA-AS3 HOXA4 HOXA3 HOXA6 HOXA5 HOXA1 HOXA2 HOXA10-AS HOXA9
GH07G026868 0.7 ENCODE dbSUPER 30.5 -226.6 -226551 1.4 JUND POLR3A HOTAIRM1 HOXA2 SNX10 GC07P026846 RPL7AP38
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOTAIRM1 on UCSC Golden Path with GeneCards custom track

Promoters for HOTAIRM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000325311 1753 3601 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 FOS ZNF263 SP3

Genomic Location for HOTAIRM1 Gene

Chromosome:
7
Start:
27,095,647 bp from pter
End:
27,100,265 bp from pter
Size:
4,619 bases
Orientation:
Plus strand

Genomic View for HOTAIRM1 Gene

Genes around HOTAIRM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOTAIRM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOTAIRM1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HOTAIRM1 Gene

Proteins for HOTAIRM1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for HOTAIRM1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for HOTAIRM1 Gene

Domains & Families for HOTAIRM1 Gene

Gene Families for HOTAIRM1 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HOTAIRM1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for HOTAIRM1 Gene

Function for HOTAIRM1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HOTAIRM1 Gene

Localization for HOTAIRM1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for HOTAIRM1 Gene

Pathways & Interactions for HOTAIRM1 Gene

SuperPathways for HOTAIRM1 Gene

PathCards logo More details on SuperPathways for HOTAIRM1
No Data Available

Interacting Proteins for HOTAIRM1 Gene

Gene Ontology (GO) - Biological Process for HOTAIRM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HOTAIRM1 Gene

Drugs & Compounds for HOTAIRM1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HOTAIRM1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HOTAIRM1 Gene

(4) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOTAIRM1 Gene

HOXA transcript antisense RNA, myeloid-specific 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOTAIRM1 Gene

No ASD Table

Relevant External Links for HOTAIRM1 Gene

GeneLoc Exon Structure for
HOTAIRM1
ECgene alternative splicing isoforms for
HOTAIRM1

Expression for HOTAIRM1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOTAIRM1 Gene

mRNA expression in normal human tissues for HOTAIRM1 Gene
mRNA expression by GTEx for HOTAIRM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOTAIRM1 Gene:

HOTAIRM1

SOURCE GeneReport for Unigene cluster for HOTAIRM1 Gene:

Hs.445239
genes like me logo Genes that share expression patterns with HOTAIRM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOTAIRM1 Gene

Orthologs for HOTAIRM1 Gene

Evolution for HOTAIRM1 Gene

ENSEMBL:
Gene Tree for HOTAIRM1 (if available)
TreeFam:
Gene Tree for HOTAIRM1 (if available)

No data available for Orthologs for HOTAIRM1 Gene

Paralogs for HOTAIRM1 Gene

No data available for Paralogs for HOTAIRM1 Gene

Variants for HOTAIRM1 Gene

Sequence variations from dbSNP and Humsavar for HOTAIRM1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs104894017 Pathogenic 27,095,829(-) GCCTA(C/G)CCCTC upstream-variant-2KB, reference, stop-gained
rs104894018 Pathogenic 27,095,837(-) CAGCC(C/G/T)GAGCC upstream-variant-2KB, reference, missense
rs117630421 Likely benign 27,100,618(+) GGGAA(A/G)GGGTA intron-variant, utr-variant-3-prime
rs2074398 Likely benign 27,095,700(+) tgatg(A/G)tggtg upstream-variant-2KB, reference, synonymous-codon
rs368428758 Likely benign 27,095,695(+) GGTGG(-/CGA)TGGTG upstream-variant-2KB, cds-indel

Structural Variations from Database of Genomic Variants (DGV) for HOTAIRM1 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
dgv11244n54 CNV loss 21841781
esv3612654 CNV loss 21293372
nsv606464 CNV loss 21841781
nsv7393 OTHER inversion 18451855

Relevant External Links for HOTAIRM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOTAIRM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for HOTAIRM1 Gene

Disorders for HOTAIRM1 Gene

Relevant External Links for HOTAIRM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOTAIRM1

No disorders were found for HOTAIRM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOTAIRM1 Gene

Publications for HOTAIRM1 Gene

  1. A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. (PMID: 19144990) Zhang X. … Newburger P.E. (Blood 2009) 2 3 64
  2. The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature. (PMID: 26436590) DA-az-BeyA! M. … Esteve J. (Oncotarget 2015) 3 64
  3. Long intergenic non-coding RNA HOTAIRM1 regulates cell cycle progression during myeloid maturation in NB4 human promyelocytic leukemia cells. (PMID: 24824789) Zhang X. … Newburger P.E. (RNA Biol 2014) 3 64
  4. lncRNAdb: a reference database for long noncoding RNAs. (PMID: 21112873) Amaral P.P. … Mattick J.S. (Nucleic Acids Res. 2011) 3 64

Products for HOTAIRM1 Gene

Sources for HOTAIRM1 Gene

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