Subcategory (RNA class) for HOTAIR Gene
Quality Score for this RNA gene is
Aliases for HOTAIR Gene
External Ids for HOTAIR Gene
Previous GeneCards Identifiers for HOTAIR Gene
This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with HOXC genes. It represses transcription of HOXD genes on chromosome 2 in trans. This gene is shuttled from chromosome 12 to chromosome 2 by a component of Polycomb Repressive Complex 2 (PRC2). This gene interacts with both PRC2 and lysine specific demethylase 1 (LSD1) complexes through its 5' and 3' domains, respectively, and serves as a scaffold to assemble PRC2 and LSD1 complexes to the HOXD gene cluster. It couples H3K27 methylation and H3K4 demethylation for epigenetic silencing of HOXD genes in multiple tissues. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2013]
GeneCards Summary for HOTAIR Gene
HOTAIR (HOX Transcript Antisense RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with HOTAIR include pediculus humanus capitis infestation and retroperitoneal cancer.