HORMAD2 Gene
protein-coding GIFtS: 43
GCID: GC22P030479
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HORMA domain containing 2
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Aliases
for HORMAD2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| HORMA Domain Containing 21 2 | | MGC267101 | | HORMA Domain-Containing Protein 22 |
Export aliases for HORMAD2 gene to outside databasesPrevious GC identifers: GC22P028802 GC22P013438 |
Summaries
for HORMAD2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HORM2_HUMAN, Q8N7B1Function: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a keyrole in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-upof ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing ofunsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strandbreak-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex bodyformation (By similarity)
Gene Wiki entry for HORMAD2
|
Genomic Views
for HORMAD2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HORMAD2 gene promoter:
Nkx2-5 POU6F1 (c2) RORalpha2 POU2F2C RORalpha1 MEF-2A S8 IRF-7A c-Myb aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for HORMAD2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HORMAD2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2HORMAD2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P030479: view genomic region
(about GC identifiers)
Start:
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30,476,163 bp from pter |
End:
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30,606,866 bp from pter |
Size:
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130,704 bases |
Orientation:
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plus strand |
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Proteins
for HORMAD2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HORM2_HUMAN, Q8N7B1 (See
protein sequence)Recommended Name: HORMA domain-containing protein 2 Size: 307 amino acids; 35284 Da
Subunit: Interacts with HORMAD1 (By similarity)
Subcellular location: Nucleus. Chromosome (By similarity). Note=Preferentially localizes to unsynapsed or desynapsedchromosomal regions during the male and female prophase I stage of meiosis. TRIP13 is required for depletion fromsynapsed chromosomes (By similarity)
Secondary accessions: B5MEB2 Q8NHR2Explore the universe of human proteins at neXtProt for HORMAD2: NX_Q8N7B1
Post-translational modifications:
Phosphorylated in a SPO11-dependent manner (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N7B1
HORMAD2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689723.1
ENSEMBL proteins: ENSP00000336984 ENSP00000393415 ENSP00000385055 ENSP00000420761 ENSP00000420785
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HORMAD2 for ontologies About GeneDecksing
HORMAD2 Antibody Products:
Assay Products for HORMAD2: |
Protein
Domains /
Families
for HORMAD2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HORMAD2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N7B1ProtoNet protein and cluster: Q8N7B1 1 Blocks protein family: IPB003511 DNA-binding HORMA
UniProtKB/Swiss-Prot: HORM2_HUMAN, Q8N7B1Similarity: Contains 1 HORMA domain |
Function
for HORMAD2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: HORM2_HUMAN, Q8N7B1Function: Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a keyrole in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-upof ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing ofunsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strandbreak-independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for normal sex bodyformation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HORMAD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HORMAD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for HORMAD2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HORMAD2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HORMAD2 |
Animal Models:
Mouse knock-outs for HORMAD2: Hormad2tm1Kura Hormad2tm1.2Atot Hormad2tm1Atot
4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Hormad2):
HORMAD2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for HORMAD2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HORMAD2
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007126 | meiosis |
ISS | -- | | GO:0051177 | meiotic sister chromatid cohesion |
ISS | -- |
HORMAD2 for ontologies About GeneDecksing
|
Drugs & Compounds
for HORMAD2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for HORMAD2
Search CenterWatch for drugs/clinical trials and news about HORMAD2 / HORM2
|
Transcripts
for HORMAD2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HORMAD2 gene: NM_152510.2 Unigene Cluster for HORMAD2: HORMA domain containing 2 Hs.120391 [show with all ESTs]Unigene Representative Sequence: BC0300136 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000336726(uc003agy.3) ENST00000450612 ENST00000403975 ENST00000491605
ENST00000481990 ENST00000491590
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HORMAD2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HORMAD2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HORMAD2 (NM_152510) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HORMAD2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HORMAD2 |
Additional cDNA sequence: AK098703.1 BC030013.1 CR456341.1 3 DOTS entries: DT.408694 DT.100012230 DT.100016143 24 AceView cDNA sequences: BP371324 BC030013 AA953061 AA723633 CD244491 AA905258 AI017631 BX105347 AK098703 AA917521 CR456341 AV645645 AW611598 AV645567 BI461945 NM_152510 BI459310 BG723756 AW444913 BG723149 AW197087 AI188083 AI911123 BI829841
GeneLoc Exon Structure
|
Expression
for HORMAD2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HORMAD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGATTTAGTA
About this image
See HORMAD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HORMAD2
SOURCE GeneReport for Unigene cluster: Hs.120391
UniProtKB/Swiss-Prot: HORM2_HUMAN, Q8N7B1Tissue specificity: Highly expressed in testis (at protein level). Expressed in lung adenocarcinoma and squamous cellcarcinoma (at protein level). Expressed at lower levels in the liver, brain and kidney
SABiosciences Custom PCR Arrays for HORMAD2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HORMAD2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HORMAD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HORMAD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HORMAD2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HORMAD2 |
Orthologs
for HORMAD2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for HORMAD2 gene from 4/13 species (see all 13) About this table
ENSEMBL Gene Tree for HORMAD2 (if available)
TreeFam Gene Tree for HORMAD2 (if available) |
Paralogs
for HORMAD2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HORMAD2 gene
- HORMAD12
1 SIMAP similar gene for HORMAD2 using alignment to 2 protein entries: HORM2_HUMAN (see all proteins):HORMAD1
HORMAD2 for paralogs About GeneDecksing
|
Genomic Variants
for HORMAD2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HORMAD2 (30476163 - 30606866 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HORMAD2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HORMAD2 |
|
Disorders
/ Diseases
for HORMAD2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
HORMAD2 for disorders About GeneDecksing
3  diseases for HORMAD2: About MalaCardsinflammatory bowel disease crohn's disease nephropathy
Human Genome Epidemiology (HuGE) Navigator: HORMAD2 (1 document)
Export disorders for HORMAD2 gene to outside databases
|
Publications
for HORMAD2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HORMAD2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with HORMAD2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- HORMAD2/CT46.2, a novel cancer/testis gene, is ectopically expressed in lung cancer tissues. (PubMed id 22893617)2 Liu M.... Sha J. (2012)
- Genome-wide association study identifies susceptibili ty loci for IgA nephropathy. (PubMed id 21399633)1 Gharavi A.G....Lifton R.P. (2011)
- Association between genome-wide association studies r eported SNPs and pediatric-onset Crohn's disease in Canadian children. (PubMed id 20473688)1 Amre D.K....Levy E. (2010)
- Common variants at five new loci associated with earl y-onset inflammatory bowel disease. (PubMed id 19915574)1 Imielinski M....McGovern D. (2009)
- Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein. (PubMed id 15999985)2 Chen Y.-T.... Simpson A.J.G. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
|
External Searches for HORMAD2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing HORMAD2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing HORMAD2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing HORMAD2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HORMAD2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for HORMAD2 gene:
Search GeneIP for patents involving HORMAD2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HORMAD2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HORMAD2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HORMAD2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HORMAD2 | | | OriGene Protein Over-expression Lysate for HORMAD2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HORMAD2 | | OriGene 3'-UTR Clone for HORMAD2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HORMAD2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HORMAD2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for HORMAD2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HORMAD2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HORMAD2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HORMAD2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HORMAD2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HORMAD2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HORMAD2 |
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 | | | HORMAD2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HORMAD2 |
|  |  |  | | | | Search ThermoFisher Antibodies for HORMAD2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HORMAD2 |
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