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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HORMAD1 Gene

protein-coding   GIFtS: 49
GCID: GC01M150670

HORMA domain containing 1

 Explore 4 diseases affiliated with
HORMAD1 via our new
 Human Malady Compendium 
Biological research products
for HORMAD1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
HORMA Domain Containing 11 2     Newborn Ovary HORMA Protein2 3
CT461 2 3     DKFZP434A13151
NOHMA2 3 5     HORMA Domain-Containing Protein 12
Cancer/Testis Antigen 462 3     

External Ids:    HGNC: 252451   Entrez Gene: 840722   Ensembl: ENSG000001434527   OMIM: 6098245   UniProtKB: Q86X243   

Export aliases for HORMAD1 gene to outside databases

Previous GC identifers: GC01M147484 GC01M148937 GC01M122049


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HORMAD1:
This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a role in
cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a potential
marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively spliced
transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24
Function: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that
sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by
increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently
of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase
checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to
form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes
(By similarity)

Gene Wiki entry for HORMAD1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HORMAD1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   HNF-1A   Gfi-1   Nkx3-1 v2   HNF-1   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHORMAD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HORMAD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HORMAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

HORMAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HORMAD1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150670:  view genomic region     (about GC identifiers)

Start:
150,670,536 bp from pter      End:
150,693,364 bp from pter
Size:
22,829 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24 (See protein sequence)
Recommended Name: HORMA domain-containing protein 1  
Size: 394 amino acids; 45200 Da
Subunit: Interacts with HORMAD2 (By similarity)
Subcellular location: Nucleus (By similarity). Chromosome (By similarity). Note=Preferentially localizes to unsynapsed
or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from
synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal
regions (By similarity)
Sequence caution: Sequence=AAH33014.1; Type=Frameshift; Positions=89;
Secondary accessions: A6NMK2 B3KUK1 Q4G114 Q5T5I3 Q5T5I4 Q5T5I5 Q6FIC1 Q9H0K8
Alternative splicing: 5 isoforms:  Q86X24-1   Q86X24-2   Q86X24-3   Q86X24-4   Q86X24-5   

Explore the universe of human proteins at neXtProt for HORMAD1: NX_Q86X24

Post-translational modifications:

  • Phosphorylated at Ser-377 in a SPO11-dependent manner (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86X24

  • HORMAD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186758.1  NP_115508.2  

    ENSEMBL proteins: 
     ENSP00000357991   ENSP00000326489   ENSP00000355167   ENSP00000357983   ENSP00000401940  
     ENSP00000357989  

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    Uscn Proteins for HORMAD1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome ISS--
    GO:0045111intermediate filament cytoskeleton IDA--


    HORMAD1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HORMAD1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003511 HORMA_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q86X24

    ProtoNet protein and cluster: Q86X24

    1 Blocks protein family: IPB003511 DNA-binding HORMA

    UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24
    Similarity: Contains 1 HORMA domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24
    Function: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that
    sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by
    increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently
    of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase
    checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to
    form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes
    (By similarity)

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    Animal Models:
         Mouse knock-outs for HORMAD1: Hormad1tm1.2Atot Hormad1tm1Rajk
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hormad1):
     cellular  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    HORMAD1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HORMAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for HORMAD1 (ENSP000003551674) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC4ENSP000003106224STRING: ENSP00000310622
    C1orf146ENSP000003594014STRING: ENSP00000359401
    CACYBPENSP000003566524STRING: ENSP00000356652
    CELA3AENSP000002901224STRING: ENSP00000290122
    COL11A1ENSP000003511634STRING: ENSP00000351163
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development ISS--
    GO:0007126meiosis ISS--
    GO:0007130synaptonemal complex assembly ISS--
    GO:0007283spermatogenesis ISS--
    GO:0030154cell differentiation IEA--


    HORMAD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HORMAD1
    Search CenterWatch for drugs/clinical trials and news about HORMAD1 / HORM1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HORMAD1 gene (2 alternative transcripts): 
    NM_001199829.1  NM_032132.4  

    Unigene Cluster for HORMAD1:

    HORMA domain containing 1
    Hs.298312  [show with all ESTs]
    Unigene Representative Sequence: NM_032132
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368995(uc001evm.2) ENST00000322343 ENST00000361824 ENST00000470397
    ENST00000486497 ENST00000368987 ENST00000442853 ENST00000476530 ENST00000368993(uc001evk.2 uc001evl.2)


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    hsa-miR-522 hsa-miR-224* hsa-miR-374c hsa-miR-338-5p hsa-miR-548t hsa-miR-655 hsa-miR-493* hsa-miR-3143
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    Additional cDNA sequence: 

    AK097390.1 AK098633.1 AL136755.2 AY626344.1 BC033014.1 BC047406.1 CR533505.1 

    8 DOTS entries:

    DT.302948  DT.97786043  DT.75101119  DT.121426225  DT.102841846  DT.100751606  DT.121426240  DT.40208874 

    24/51 AceView cDNA sequences (see all 51):

    AA505930 AK097390 BC047406 BP371325 BP371672 NM_032132 AL136755 BP370247 
    AK098633 AY626344 BI829138 CD243828 BM554190 BI562548 BQ435603 AI791283 
    BG701778 AW235448 BC033014 CD358185 BU561417 BI464767 BI826472 AI791494 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HORMAD1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:              -                       -                                                                 -     -                           
    SP2:                                                                                                              -                           
    SP3:                                                                                                                                          
    SP4:                                                                                                  -     -     -                           
    SP5:                                                                                                        -                                 


    ECgene alternative splicing isoforms for HORMAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HORMAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATCTGGGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HORMAD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HORMAD1

    SOURCE GeneReport for Unigene cluster: Hs.298312

    UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24
    Tissue specificity: Testis-specific. Over-expressed in carcinomas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HORMAD1 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hormad11 , 5 HORMA domain containing 11, 5 85.94(n)1
    79.89(a)1
      3 (40.74 cM)5
    679811  NM_026489.21  NP_080765.11 
     955596775 
    chicken
    (Gallus gallus)
    Aves HORMAD11 HORMA domain containing 1 66.94(n)
    64.93(a)
      425071  XM_422864.2  XP_422864.2 
    lizard
    (Anolis carolinensis)
    Reptilia HORMAD16
    --
    63(a)
    1 ↔ 1
    GL343862.1(43527-61301)
    zebrafish
    (Danio rerio)
    Actinopterygii CF997106.12   -- 74.05(n)    CF997106.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ASY11 DNA-binding HORMA-like protein 43.9(n)
    28.68(a)
      843058  NM_105405.1  NP_564896.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05068001 hypothetical protein 46.42(n)
    35.12(a)
      4347514  NM_001070145.1  NP_001063610.1 


    ENSEMBL Gene Tree for HORMAD1 (if available)
    TreeFam Gene Tree for HORMAD1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HORMAD1 gene
    HORMAD22  
    1 SIMAP similar gene for HORMAD1 using alignment to 2 protein entries:     HORM1_HUMAN (see all proteins):
    HORMAD2

    HORMAD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HORMAD1
    PGOHUM00000243245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/334 NCBI SNPs in HORMAD1 are shown (see all 334    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512134761,2
    --150671683(+) AATATC/GTAGTT 2 -- int10--------
    rs741249731,2
    C,--150671814(+) TACTAG/CGAGGA 2 -- int12Minor allele frequency- C:0.08WA 120
    rs1886470741,2
    --150671817(+) TAGGAG/TGAGAC 2 -- int10--------
    rs1391527811,2
    --150671873(+) CTACTA/TCAGTT 2 -- int10--------
    rs1911733861,2
    --150671879(+) CAGTTC/TTGATC 2 -- int10--------
    rs176000201,2
    C,F,H,--150671887(+) ATCTCT/CAGAAA 2 -- int110Minor allele frequency- C:0.03NA NS 944
    rs1824971351,2
    --150672041(+) CTGTCA/GCCAGG 2 -- int10--------
    rs125650381,2
    C,A,H--150672063(+) tggcgC/Tgatct 2 -- int10--------
    rs2017740341,2
    --150672167(+) GCTAT-/TGTTTTT 2 -- int10--------
    rs341543011,2
    C,--150672168(+) CTATT-/GTTTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for HORMAD1 (150670536 - 150693364 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for HORMAD1
         3 CNVs: 1335 48133 97508
         7 Indels: 39657 44450 23967 39658 97509 42274 60889
    Human Gene Mutation Database (HGMD): HORMAD1

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HORMAD1 for disorders           About GeneDecksing

    OMIM gene information: 609824    OMIM disorders: --

    4 diseases for HORMAD1:    About MalaCards
    gastric cancer    breast cancer    melanoma    carcinoma


    Export disorders for HORMAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HORMAD1 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with HORMAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein. (PubMed id 15999985)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (2005)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    3. Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein. (PubMed id 15567723)1, 2, 9 Pangas S.A.... Rajkovic A. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Single-nucleotide polymorphisms in HORMAD1 may be a ri sk factor for azoospermia caused by meiotic arrest in Japanese patients. (PubMed id 22407170)1 Miyamoto T....Sengoku K. (2012)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. Integrated profiling of basal and luminal breast cancers. (PubMed id 18089785)1 AdAclaA^de J....Chaffanet M. (2007)
    8. Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. (PubMed id 16331256)1 Aung P.P....Yasui W. (2006)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    10. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84072 HGNC: 25245 AceView: NOHMA Ensembl:ENSG00000143452 euGenes: HUgn84072
    ECgene: HORMAD1 H-InvDB: HORMAD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HORMAD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HORMAD1 gene:
    Search GeneIP for patents involving HORMAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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