Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HORMAD1 Gene

protein-coding   GIFtS: 51
GCID: GC01M150670

HORMA Domain Containing 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
HORMA Domain Containing 11 2
Cancer/Testis Antigen 461 2 3
NOHMA2 3 5
Newborn Ovary HORMA Protein2 3
CT462 3
HORMA Domain-Containing Protein 12

External Ids:    HGNC: 252451   Entrez Gene: 840722   Ensembl: ENSG000001434527   OMIM: 6098245   UniProtKB: Q86X243   

Export aliases for HORMAD1 gene to outside databases

Previous GC identifers: GC01M147484 GC01M148937 GC01M122049


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HORMAD1 Gene:
This gene encodes a HORMA domain-containing protein. HORMA domains are involved in chromatin binding and play a
role in cell cycle regulation. The encoded protein may play a role in meiosis, and expression of this gene is a
potential marker for cancer. A pseudogene of this gene is located on the long arm of chromosome 6. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Dec
2010)

GeneCards Summary for HORMAD1 Gene: 
HORMAD1 (HORMA domain containing 1) is a protein-coding gene. Diseases associated with HORMAD1 include azoospermia, and gastric cancer. An important paralog of this gene is HORMAD2.

UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24
Function: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that
sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by
increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation
independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the
female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome
regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic
prophase quality control in both sexes (By similarity)

Gene Wiki entry for HORMAD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HORMAD1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   HNF-1A   Gfi-1   Nkx3-1 v2   HNF-1   FOXJ2 (long isoform)   Nkx3-1 v3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHORMAD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HORMAD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HORMAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.2

HORMAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HORMAD1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M150670:  view genomic region     (about GC identifiers)

Start:
150,670,535 bp from pter      End:
150,693,364 bp from pter
Size:
22,830 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24 (See protein sequence)
Recommended Name: HORMA domain-containing protein 1  
Size: 394 amino acids; 45200 Da
Subunit: Interacts with HORMAD2 (By similarity)
Subcellular location: Nucleus (By similarity). Chromosome (By similarity). Note=Preferentially localizes to
unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for
depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to
unsynapsed chromosomal regions (By similarity)
Sequence caution: Sequence=AAH33014.1; Type=Frameshift; Positions=89;
Secondary accessions: A6NMK2 B3KUK1 Q4G114 Q5T5I3 Q5T5I4 Q5T5I5 Q6FIC1 Q9H0K8
Alternative splicing: 5 isoforms:  Q86X24-1   Q86X24-2   Q86X24-3   Q86X24-4   Q86X24-5   

Explore the universe of human proteins at neXtProt for HORMAD1: NX_Q86X24

Explore proteomics data for HORMAD1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated at Ser-377 in a SPO11-dependent manner (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86X24

  • HORMAD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HORMAD1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186758.1  NP_115508.2  

    ENSEMBL proteins: 
     ENSP00000357991   ENSP00000326489   ENSP00000355167   ENSP00000357983   ENSP00000401940  
     ENSP00000357989  

    Human Recombinant Protein Products for HORMAD1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for HORMAD1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for HORMAD1
    GenScript Custom Purified and Recombinant Proteins Services for HORMAD1
    Novus Biologicals HORMAD1 Protein
    Novus Biologicals HORMAD1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HORMAD1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005694chromosome ISS--
    GO:0005737cytoplasm IEA--
    GO:0045111intermediate filament cytoskeleton IDA--

    HORMAD1 for ontologies           About GeneDecksing



    HORMAD1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for HORMAD1
    GenScript Custom Superior Antibodies Services for HORMAD1
    Novus Biologicals HORMAD1 Antibodies
    Abcam antibodies for HORMAD1
    Cloud-Clone Corp. Antibodies for HORMAD1 
    ThermoFisher Antibodies for HORMAD1
    LSBio Antibodies in human, mouse, rat for HORMAD1 

    Assay Products for HORMAD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for HORMAD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for HORMAD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for HORMAD1 
    Cloud-Clone Corp. CLIAs for HORMAD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003511 HORMA_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q86X24

    ProtoNet protein and cluster: Q86X24

    1 Blocks protein domain: IPB003511 DNA-binding HORMA

    UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24
    Similarity: Contains 1 HORMA domain


    HORMAD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HORM1_HUMAN, Q86X24
    Function: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that
    sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by
    increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation
    independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the
    female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome
    regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic
    prophase quality control in both sexes (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    HORMAD1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Hormad1):
     cellular  embryogenesis  endocrine/exocrine gland  homeostasis/metabolism  reproductive system 

    HORMAD1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for HORMAD1: Hormad1tm1.2Atot Hormad1tm1Rajk

       inGenious Targeting Laboratory - Custom generated mouse model solutions for HORMAD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HORMAD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HORMAD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HORMAD1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HORMAD1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HORMAD1 (see all 9):
    hsa-miR-522 hsa-miR-224* hsa-miR-374c hsa-miR-338-5p hsa-miR-548t hsa-miR-655 hsa-miR-493* hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidHORMAD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HORMAD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HORMAD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for HORMAD1
    Sirion Biotech Customized adenovirus for overexpression of HORMAD1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for HORMAD1 (see all 7)
    OriGene ORF clones in mouse, rat for HORMAD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HORMAD1 (NM_032132)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HORMAD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HORMAD1
    Sirion Biotech Customized lentivirus for stable overexpression of HORMAD1 
                         Customized lentivirus expression plasmids for stable overexpression of HORMAD1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for HORMAD1
    Search LifeMap BioReagents cell lines for HORMAD1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HORMAD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HORMAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for HORMAD1 (ENSP000003551674) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOBEC4ENSP000003106224STRING: ENSP00000310622
    C1orf146ENSP000003594014STRING: ENSP00000359401
    CACYBPENSP000003566524STRING: ENSP00000356652
    CELA3AENSP000002901224STRING: ENSP00000290122
    COL11A1ENSP000003511634STRING: ENSP00000351163
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development ISS--
    GO:0007126meiosis ISS--
    GO:0007130synaptonemal complex assembly ISS--
    GO:0007283spermatogenesis ISS--
    GO:0030154cell differentiation IEA--

    HORMAD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HORMAD1 (HORM1)

    Search CenterWatch for drugs/clinical trials and news about HORMAD1 / HORM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HORMAD1 gene (2 alternative transcripts): 
    NM_001199829.1  NM_032132.4  

    Unigene Cluster for HORMAD1:

    HORMA domain containing 1
    Hs.298312  [show with all ESTs]
    Unigene Representative Sequence: NM_032132
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368995(uc001evm.2) ENST00000322343 ENST00000361824 ENST00000470397
    ENST00000486497 ENST00000368987 ENST00000442853 ENST00000476530 ENST00000368993(uc001evk.2 uc001evl.2)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HORMAD1
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate HORMAD1 (see all 9):
    hsa-miR-522 hsa-miR-224* hsa-miR-374c hsa-miR-338-5p hsa-miR-548t hsa-miR-655 hsa-miR-493* hsa-miR-3143
    SwitchGear 3'UTR luciferase reporter plasmidHORMAD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for HORMAD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HORMAD1
    Clone
    Products:
         
    OriGene clones in human, mouse for HORMAD1 (see all 7)
    OriGene ORF clones in mouse, rat for HORMAD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): HORMAD1 (NM_032132)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HORMAD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HORMAD1
    Sirion Biotech Customized lentivirus for stable overexpression of HORMAD1 
                         Customized lentivirus expression plasmids for stable overexpression of HORMAD1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for HORMAD1
    OriGene qSTAR qPCR primer pairs in human, mouse for HORMAD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HORMAD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HORMAD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HORMAD1

    Additional mRNA sequence: 

    AK097390.1 AK098633.1 AL136755.2 AY626344.1 BC033014.1 BC047406.1 CR533505.1 

    8 DOTS entries:

    DT.302948  DT.97786043  DT.75101119  DT.121426225  DT.102841846  DT.100751606  DT.121426240  DT.40208874 

    24/51 AceView cDNA sequences (see all 51):

    BI829138 BP371672 AA505930 AY626344 AK098633 BM554190 BP370247 BC047406 
    AL136755 BP371325 NM_032132 AK097390 CD243828 BG721909 BG717169 BU561417 
    BC033014 BU853985 AL041831 CD358185 AW235448 BU853414 AI732538 BI562548 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HORMAD1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d · 15e
    SP1:              -                       -                                                                 -     -                           
    SP2:                                                                                                              -                           
    SP3:                                                                                                                                          
    SP4:                                                                                                  -     -     -                           
    SP5:                                                                                                        -                                 


    ECgene alternative splicing isoforms for HORMAD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HORMAD1 expression in normal human tissues (normalized intensities)      HORMAD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATCTGGGAG
    HORMAD1 Expression
    About this image


    HORMAD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
             sperm   
     
     Gonad
             XY Germ Cells Testis Cord
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord

    See HORMAD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HORMAD1

    SOURCE GeneReport for Unigene cluster: Hs.298312

    UniProtKB/Swiss-Prot: HORM1_HUMAN, Q86X24
    Tissue specificity: Testis-specific. Over-expressed in carcinomas

        SABiosciences Custom PCR Arrays for HORMAD1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for HORMAD1
    OriGene qSTAR qPCR primer pairs in human, mouse for HORMAD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HORMAD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HORMAD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HORMAD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HORMAD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HORMAD1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hormad11 , 5 HORMA domain containing 11, 5 85.94(n)1
    79.89(a)1
      3 (40.74 cM)5
    679811  NM_026489.21  NP_080765.11 
     955596775 
    chicken
    (Gallus gallus)
    Aves HORMAD11 HORMA domain containing 1 66.94(n)
    64.93(a)
      425071  XM_422864.2  XP_422864.2 
    lizard
    (Anolis carolinensis)
    Reptilia HORMAD16
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343862.1(43527-61301)
    zebrafish
    (Danio rerio)
    Actinopterygii CF997106.12   -- 74.05(n)    CF997106.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HOP1(YIL072W)4 Meiosis-specific DNA binding protein that displays more   --   9(226602-228419) 854738  NP_012193.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ASY11 DNA-binding HORMA-like protein 43.9(n)
    28.68(a)
      843058  NM_105405.1  NP_564896.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g05068001 hypothetical protein 46.42(n)
    35.12(a)
      4347514  NM_001070145.1  NP_001063610.1 


    ENSEMBL Gene Tree for HORMAD1 (if available)
    TreeFam Gene Tree for HORMAD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HORMAD1 gene
    HORMAD22  
    1 SIMAP similar gene for HORMAD1 using alignment to 2 protein entries:     HORM1_HUMAN (see all proteins):
    HORMAD2

    HORMAD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for HORMAD1
    PGOHUM00000243245


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/408 SNPs in HORMAD1 are shown (see all 408)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512134761,2
    C--150671683(+) AATATC/GTAGTT 2 -- int10--------
    rs741249731,2
    C,F--150671814(+) TACTAG/CGAGGA 2 -- int12Minor allele frequency- C:0.08WA 120
    rs1886470741,2
    --150671817(+) TAGGAG/TGAGAC 2 -- int10--------
    rs1391527811,2
    --150671873(+) CTACTA/TCAGTT 2 -- int10--------
    rs1911733861,2
    --150671879(+) CAGTTC/TTGATC 2 -- int10--------
    rs176000201,2
    C,F,H--150671887(+) ATCTCT/CAGAAA 2 -- int110Minor allele frequency- C:0.03NA NS 944
    rs1824971351,2
    --150672041(+) CTGTCA/GCCAGG 2 -- int10--------
    rs125650381,2
    C,A,H--150672063(+) tggcgC/Tgatct 2 -- int10--------
    rs2017740341,2
    C--150672167(+) GCTAT-/TGTTTTT 2 -- int10--------
    rs341543011,2
    C--150672168(+) CTATT-/GTTTTT 2 -- int10--------

    HapMap Linkage Disequilibrium report for HORMAD1 (150670535 - 150693364 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for HORMAD1 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717807CNV Deletion23290073
    esv3600CNV Deletion18987735
    esv2570262CNV Deletion19546169
    esv2238986CNV Deletion18987734
    esv1594619CNV Deletion17803354
    esv992009CNV Deletion20482838
    esv2482983CNV Deletion19546169
    esv2609983CNV Deletion19546169
    esv9188CNV Loss19470904
    nsv437158CNV Loss16327808


    Human Gene Mutation Database (HGMD): HORMAD1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing HORMAD1
    DNA2.0 Custom Variant and Variant Library Synthesis for HORMAD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609824    OMIM disorders: --

    4 diseases for HORMAD1:    About MalaCards
    azoospermia    gastric cancer    melanoma    breast cancer


    HORMAD1 for disorders           About GeneDecksing


    Export disorders for HORMAD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HORMAD1 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with HORMAD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein. (PubMed id 15999985)1, 2, 3 Chen Y.-T.... Simpson A.J.G. (2005)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    3. Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein. (PubMed id 15567723)1, 2, 9 Pangas S.A.... Rajkovic A. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (PubMed id 23585552)1 Kirin M....Mitry D. (2013)
    6. Biological significance of HORMA domain containing pro tein 1 (HORMAD1) in epithelial ovarian carcinoma. (PubMed id 22776561)1 Shahzad M.M....Sood A.K. (2013)
    7. Single-nucleotide polymorphisms in HORMAD1 may be a ri sk factor for azoospermia caused by meiotic arrest in Japanese patients. (PubMed id 22407170)1 Miyamoto T....Sengoku K. (2012)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    9. Integrated profiling of basal and luminal breast cancers. (PubMed id 18089785)1 AdAclaA^de J....Chaffanet M. (2007)
    10. Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer. (PubMed id 16331256)1 Aung P.P....Yasui W. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84072 HGNC: 25245 AceView: NOHMA Ensembl:ENSG00000143452 euGenes: HUgn84072
    ECgene: HORMAD1 H-InvDB: HORMAD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HORMAD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HORMAD1 gene:
    Search GeneIP for patents involving HORMAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for HORMAD1  
     OriGene qPCR primer pairs and template standards for HORMAD1   OriGene Protein Over-expression Lysate for HORMAD1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for HORMAD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for HORMAD1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for HORMAD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for HORMAD1   OriGene Custom Protein Services for HORMAD1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HORMAD1
     QIAGEN SeqTarget long-range PCR primers for resequencing HORMAD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HORMAD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HORMAD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HORMAD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HORMAD1
     GenScript Custom Purified and Recombinant Proteins Services for HORMAD1 GenScript cDNA clones with any tag delivered in your preferred vector for HORMAD1
     GenScript Custom Assay Services for HORMAD1 GenScript Custom Superior Antibodies Services for HORMAD1
     GenScript Custom overexpressing Cell Line Services for HORMAD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in HORMAD1 promoter
     Search Chromatin IP Primers for HORMAD1
     RT2 qPCR Primer Assay in human, mouse, rat HORMAD1
     Search GNC Networks for HORMAD1
     SABiosciences Custom PCR Arrays for HORMAD1
     Search Tocris compounds for HORMAD1 (HORM1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     HORMAD1 antibodies
     HORMAD1 proteins
     HORMAD1 lysates
     Antibodies for HORMAD1
     See all of Abcam's Antibodies, Kits and Proteins for HORMAD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for HORMAD1
     Antibodies for HORMAD1
     ELISAs for HORMAD1
     CLIAs for HORMAD1
     Search LifeMap BioReagents cell lines for HORMAD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HORMAD1
     SwitchGear 3'UTR luciferase reporter plasmids for HORMAD1
     SwitchGear Promoter luciferase reporter plasmids for HORMAD1
     ThermoFisher Antibodies for HORMAD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HORMAD1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for HORMAD1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HORMAD1
    Customized:
     lentivirus for stable overexpression of HORMAD1
     lentivirus expression plasmids for stable overexpression of HORMAD1
     adenovirus for overexpression of HORMAD1
     LSBio Antibodies in human, mouse, rat for HORMAD1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      HORMAD1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4