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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOPX Gene

protein-coding   GIFtS: 45
GCID: GC04M057514

HOP Homeobox

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
HOP Homeobox1 2     OB12 3
HOP2 3 5     Homeobox Only Domain1
Lung Cancer-Associated Y Protein2 3     CAMEO2
Not Expressed In Choriocarcinoma Protein 12 3     SMAP312
Odd Homeobox Protein 12 3     TOTO2
HOD2 3     Homeodomain-Only Protein2
LAGY2 3     Not Expressed In Choriocarcinoma Clone 12
NECC12 3     Odd Homeobox 1 Protein2

External Ids:    HGNC: 249611   Entrez Gene: 845252   Ensembl: ENSG000001714767   OMIM: 6072755   UniProtKB: Q9BPY83   

Export aliases for HOPX gene to outside databases

Previous GC identifers: GC04M057210 GC04M053468


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOPX Gene:
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA
binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested
the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest
that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene
expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for
this gene. (provided by RefSeq, Feb 2009)

GeneCards Summary for HOPX Gene: 
HOPX (HOP homeobox) is a protein-coding gene. Diseases associated with HOPX include actinomycosis, and choriocarcinoma. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and
development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent
cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF
binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF.
Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor

Gene Wiki entry for HOPX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022853.15  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOPX gene promoter:
         Max1   FOXD3   AREB6   Egr-2   MEF-2A   S8   Ik-2   aMEF-2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOPX promoter sequence
   Search SABiosciences Chromatin IP Primers for HOPX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOPX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

HOPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOPX gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M057514:  view genomic region     (about GC identifiers)

Start:
57,514,154 bp from pter      End:
57,548,065 bp from pter
Size:
33,912 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8 (See protein sequence)
Recommended Name: Homeodomain-only protein  
Size: 73 amino acids; 8260 Da
Subunit: Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases
such as HDAC2 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8K0Z2 E9PB55 G3V294 Q8N0V6 Q96CI1
Alternative splicing: 4 isoforms:  Q9BPY8-1   Q9BPY8-2   Q9BPY8-3   Q9BPY8-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for HOPX: NX_Q9BPY8

HOPX Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins (5 alternative transcripts): 
NP_001138931.1  NP_001138932.1  NP_115884.4  NP_631957.1  NP_631958.1  

ENSEMBL proteins: 
 ENSP00000422175   ENSP00000424101   ENSP00000452340   ENSP00000370654   ENSP00000315198  
 ENSP00000452098   ENSP00000452003   ENSP00000451794   ENSP00000370659   ENSP00000337330  
 ENSP00000451631   ENSP00000396275   ENSP00000450527  

Human Recombinant Protein Products for HOPX: 
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OriGene Purified Protein for HOPX
OriGene Protein Over-expression Lysate for HOPX
OriGene MassSpec for HOPX 
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GenScript Custom Purified and Recombinant Proteins Services for HOPX
Novus Biologicals HOPX Proteins
Novus Biologicals HOPX Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for HOPX
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA17192267

HOPX for ontologies           About GeneDecksing



HOPX Antibody Products: 
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Abcam antibodies for HOPX
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LSBio Antibodies in human, mouse, rat for HOPX 

Assay Products for HOPX: 
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
PRD: Homeoboxes / PRD class

2 InterPro protein domains:
 IPR001356 Homeodomain
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9BPY8

ProtoNet protein and cluster: Q9BPY8

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Similarity: Contains 1 homeobox DNA-binding domain


HOPX for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: HOP_HUMAN, Q9BPY8
Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and
development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent
cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF
binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF.
Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding ----
GO:0043565sequence-specific DNA binding IEA--
     
HOPX for ontologies           About GeneDecksing


Phenotypes:
     8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hopx):
 cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  mortality/aging 
 muscle  no phenotypic analysis  respiratory system 

HOPX for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for HOPX 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for HOPX

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOPX 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOPX 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOPX
7 QIAGEN miScript miRNA Assays for microRNAs that regulate HOPX:
hsa-miR-548p hsa-miR-3152-3p hsa-miR-493* hsa-miR-586 hsa-miR-3924 hsa-miR-1286 hsa-miR-1305
SwitchGear 3'UTR luciferase reporter plasmidHOPX 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for HOPX
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOPX

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for HOPX
Sirion Biotech Customized adenovirus for overexpression of HOPX

Clone
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Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for HOPX (see all 26)
OriGene ORF clones in mouse, rat for HOPX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): HOPX (NM_139211)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOPX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOPX
Sirion Biotech Customized lentivirus for stable overexpression of HOPX 
                     Customized lentivirus expression plasmids for stable overexpression of HOPX 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for HOPX
Search LifeMap BioReagents cell lines for HOPX
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOPX


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOPX

5/8 Interacting proteins for HOPX (Q9BPY83) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
HDAC2Q927693I2D: score=2 
SRFP118313I2D: score=2 
AGTP010193I2D: score=1 
EPC1Q9H2F53I2D: score=1 
GZMBP101443I2D: score=1 
About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0001829trophectodermal cell differentiation IDA17576768
GO:0006351transcription, DNA-dependent IEA--
GO:0006355regulation of transcription, DNA-dependent ----
GO:0007507heart development IEA--

HOPX for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HOPX (HOP)

Search CenterWatch for drugs/clinical trials and news about HOPX / HOP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HOPX gene (5 alternative transcripts): 
NM_001145459.1  NM_001145460.1  NM_032495.5  NM_139211.4  NM_139212.3  

Unigene Cluster for HOPX:

HOP homeobox
Hs.619396  [show with all ESTs]
Unigene Representative Sequence: NM_001145460
16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000508121 ENST00000503639(uc011cad.1 uc003hbz.2) ENST00000553379
ENST00000381255 ENST00000317745 ENST00000555760 ENST00000556614 ENST00000556376
ENST00000381260 ENST00000337881 ENST00000503864 ENST00000557328 ENST00000605395
ENST00000506661 ENST00000420433(uc003hca.2 uc003hcb.2 uc003hce.2)
ENST00000554144(uc003hcc.2 uc003hcd.2)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOPX
7 QIAGEN miScript miRNA Assays for microRNAs that regulate HOPX:
hsa-miR-548p hsa-miR-3152-3p hsa-miR-493* hsa-miR-586 hsa-miR-3924 hsa-miR-1286 hsa-miR-1305
SwitchGear 3'UTR luciferase reporter plasmidHOPX 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for HOPX
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOPX
Clone
Products:
     
OriGene clones in human, mouse for HOPX (see all 26)
OriGene ORF clones in mouse, rat for HOPX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): HOPX (NM_139211)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOPX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOPX
Sirion Biotech Customized lentivirus for stable overexpression of HOPX 
                     Customized lentivirus expression plasmids for stable overexpression of HOPX 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HOPX
OriGene qSTAR qPCR primer pairs in human, mouse for HOPX
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOPX
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOPX
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOPX

Additional mRNA sequence: 

AB019573.1 AB059408.1 AB059409.1 AB059410.2 AF454763.1 AF492675.1 AF492676.1 AF492677.1 
AF492678.1 AF492679.1 AF492680.1 AF492681.1 AK289707.1 BC014225.2 

20 DOTS entries:

DT.100037000  DT.218114  DT.100820613  DT.100820616  DT.100820612  DT.100820615  DT.100036998  DT.91768126 
DT.99939376  DT.100820611  DT.100820614  DT.91727497  DT.95164814  DT.100036997  DT.121238333  DT.95164815 
DT.121238299  DT.97779431  DT.97857570  DT.95227952 

24/338 AceView cDNA sequences (see all 338):

AL543923 BM561848 AI683579 AA152105 BG054836 AA828485 BE169416 BU687839 
AA294857 AA588028 BG208648 AB059410 AA988894 AA922773 BI754546 BM561854 
AI141452 BG196719 BQ920934 CA438939 AW593806 AA831840 F04641 AI656238 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HOPX (see all 6)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1:              -     -     -     -                                             
SP2:              -     -     -     -           -                                 
SP3:                                -           -                                 
SP4:                                -           -                                 
SP5:                                            -                                 


ECgene alternative splicing isoforms for HOPX

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HOPX expression in normal human tissues (normalized intensities)      HOPX embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGACAGATG
HOPX Expression
About this image


HOPX expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/25 selected tissues (see all 25) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 10 entries
         HyStem+BMP4-induced 4D20.8 cells
         Human Vertebral Mesenchymal Stem Cells (HVMSC)   
 
 Cartilage (Muscoskeletal System)    fully expand to see all 8 entries
         HyStem+BMP4-induced 4D20.8 cells
 
 Brain (Nervous System)    fully expand to see all 6 entries
         Mature Choroid Plexus Cells Choroid Plexus
         Medulla Oblongata
         N2/LSB/S/F8-induced cells ( Generation of midbrain dopaminergic, forebrain and hypothalamic...
         Human Astrocytes   
 
 Epithelium (Uncategorized)    fully expand to see all 5 entries
         Human Bronchial Epithelial Cells (HBEpiC)   
 
 Heart (Cardiovascular System)    fully expand to see all 4 entries
         Cardiac Crescent Cells Cardiac Crescent

Genevestigator expression for HOPX

SOURCE GeneReport for Unigene cluster: Hs.619396

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Tissue specificity: Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles,
uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer,
choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma

    SABiosciences Expression via Pathway-Focused PCR Arrays including HOPX: 
          T Helper Cell Differentiation in human mouse rat
          Cellular Stress Responses in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for HOPX
OriGene qSTAR qPCR primer pairs in human, mouse for HOPX
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOPX
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOPX
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOPX
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOPX

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for HOPX gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hopx1 , 5 HOP homeobox1, 5 89.5(n)1
91.78(a)1
  5 (41.45 cM)5
743181  NM_001159900.11  NP_001153372.11 
 770864435 
chicken
(Gallus gallus)
Aves HOPX1 HOP homeobox 75.34(n)
75.34(a)
  395241  NM_204556.1  NP_989887.1 
lizard
(Anolis carolinensis)
Reptilia HOPX6
Uncharacterized protein
56(a)
1 ↔ 1
GL343257.1(1647596-1653639)
African clawed frog
(Xenopus laevis)
Amphibia Xl.135892 Xenopus laevis transcribed sequence with weak similarity to protein refNP_115884.2 (H.sapiens) hypothetical protein SMAP31; lung cancer-associated Y protein [Homo sapiens] less 73.96(n)    BJ070536.1 
zebrafish
(Danio rerio)
Actinopterygii hopx6
HOP homeobox
43(a)
1 ↔ 1
14(1176147-1183521)


ENSEMBL Gene Tree for HOPX (if available)
TreeFam Gene Tree for HOPX (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for HOPX gene
7 SIMAP similar genes for HOPX using alignment to 2 protein entries:     HOP_HUMAN (see all proteins):
PITX2    PITX1    PAX4    DRGX    PAX6    NOBOX
RAX2

HOPX for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/761 SNPs in HOPX are shown (see all 761)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs753843231,2
F--57513667(+) GTAATC/ACCATT 5 -- ds50011Minor allele frequency- A:0.05WA 118
rs623082451,2
C,F--57513737(+) CCACCT/ATAGGG 5 -- ds50015Minor allele frequency- A:0.15NA WA EA 362
rs1424402101,2
C--57513777(+) GGGCC-/GGGGT 
 GTGGGCG
GGGGG
5 -- ds50010--------
rs3763171701,2
C--57513777(+) GGGCCA/GGGGTG 5 -- ds50010--------
rs738182141,2
C--57513788(+) TGGGCG/CGGGGG 5 -- ds50011Minor allele frequency- C:0.50WA 2
rs119440141,2
C,F,H--57513910(+) taaacC/Tgcttg 5 -- ds500111Minor allele frequency- T:0.02NS EA NA CSA 1098
rs126491541,2
C,F,H--57513912(+) AACCGC/ATTGAG 5 -- ds500121Minor allele frequency- A:0.12NS EA NA WA CSA 2340
rs1859422621,2
--57514280(+) AACTTC/TGGTGG 5 -- ut310--------
rs31846771,2
C,A--57514283(-) AAACCA/CCCAAA 5 -- ut31 ese32Minor allele frequency- C:0.02MN NA 186
rs1167401861,2
C,F--57514335(+) TCTTCT/CGGCCC 5 -- ut311Minor allele frequency- C:0.01NA 120

HapMap Linkage Disequilibrium report for HOPX (57514154 - 57548065 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/15 variations for HOPX (see all 15):    About this table     
Variant IDTypeSubtypePubMed ID
esv2659159CNV Deletion23128226
esv2421872CNV Deletion20811451
esv2661777CNV Deletion23128226
nsv10498CNV Loss18304495
nsv514214CNV Loss21397061
nsv829941CNV Loss17160897
esv24874CNV Loss19812545
nsv499041CNV Loss21111241
esv24352CNV Loss19812545
dgv87n17CNV Loss16327808

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 607275    OMIM disorders: --

11 diseases for HOPX:    About MalaCards
actinomycosis    choriocarcinoma    lung cancer    oral squamous cell carcinoma
dilated cardiomyopathy    esophageal squamous cell carcinoma    squamous cell carcinoma    esophagitis
glioblastoma    thyroiditis    gastric cancer


HOPX for disorders           About GeneDecksing

3 Novoseek inferred disease relationships for HOPX gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma 51.5 9 12573257 (4), 15457851 (3)
carcinoma squamous cell 25.7 5 15213722 (2), 18234960 (1), 12759545 (1)
tumors 0 4 7796812 (1), 18234960 (1)


Export disorders for HOPX gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for HOPX gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with HOPX)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer. (PubMed id 12759545)1, 2, 9 Chen Y.... Petersen I. (2003)
  2. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. (PubMed id 12573257)1, 2, 9 Asanoma K.... Kato H. (2003)
  3. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. (PubMed id 15213722)1, 2, 9 Lemaire F....Wasylyk B. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. (PubMed id 15381369)1, 2 Toruner G.A.... Dermody J.J. (2004)
  7. Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development. (PubMed id 14516659)1, 2 Adu J.... Mighell A.J. (2002)
  8. Hop is an unusual homeobox gene that modulates cardiac development. (PubMed id 12297045)1, 3 Chen F....Epstein J.A. (2002)
  9. Analysis of the structure and function of the transcriptional coregulator HOP. (PubMed id 16939210)1, 9 Kook H....Mackay J.P. (2006)
  10. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. (PubMed id 17192267)1, 9 Kee H.J....Kook H. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
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OMIM
NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 84525 HGNC: 24961 AceView: HOP Ensembl:ENSG00000171476 euGenes: HUgn84525
ECgene: HOPX H-InvDB: HOPX

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for HOPX Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for HOPX gene:
Search GeneIP for patents involving HOPX

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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