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Aliases for HOPX Gene

Aliases for HOPX Gene

  • HOP Homeobox 2 3
  • HOP 3 4 6
  • Not Expressed In Choriocarcinoma Protein 1 3 4
  • Lung Cancer-Associated Y Protein 3 4
  • Odd Homeobox Protein 1 3 4
  • NECC1 3 4
  • LAGY 3 4
  • HOD 3 4
  • OB1 3 4
  • Not Expressed In Choriocarcinoma Clone 1 3
  • Homeodomain-Only Protein 3
  • Odd Homeobox 1 Protein 3
  • Homeobox Only Domain 2
  • SMAP31 3
  • CAMEO 3
  • TOTO 3

External Ids for HOPX Gene

Previous GeneCards Identifiers for HOPX Gene

  • GC04M057210
  • GC04M057514
  • GC04M053468

Summaries for HOPX Gene

Entrez Gene Summary for HOPX Gene

  • The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for HOPX Gene

HOPX (HOP Homeobox) is a Protein Coding gene. Diseases associated with HOPX include choriocarcinoma and lung cancer. Among its related pathways are HOP Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding.

UniProtKB/Swiss-Prot for HOPX Gene

  • Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.

Gene Wiki entry for HOPX Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOPX Gene

Genomics for HOPX Gene

Regulatory Elements for HOPX Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOPX Gene

Start:
56,647,988 bp from pter
End:
56,681,899 bp from pter
Size:
33,912 bases
Orientation:
Minus strand

Genomic View for HOPX Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOPX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOPX Gene

Proteins for HOPX Gene

  • Protein details for HOPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPY8-HOP_HUMAN
    Recommended name:
    Homeodomain-only protein
    Protein Accession:
    Q9BPY8
    Secondary Accessions:
    • A8K0Z2
    • E9PB55
    • G3V294
    • Q8N0V6
    • Q96CI1

    Protein attributes for HOPX Gene

    Size:
    73 amino acids
    Molecular mass:
    8260 Da
    Quaternary structure:
    • Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases such as HDAC2 (By similarity).

    Alternative splice isoforms for HOPX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOPX Gene

Proteomics data for HOPX Gene at MOPED

Post-translational modifications for HOPX Gene

No Post-translational modifications

No data available for DME Specific Peptides for HOPX Gene

Domains for HOPX Gene

Gene Families for HOPX Gene

HGNC:
  • PRD :Homeoboxes / PRD class

Protein Domains for HOPX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BPY8

UniProtKB/Swiss-Prot:

HOP_HUMAN :
  • Q9BPY8
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with HOPX: view

Function for HOPX Gene

Molecular function for HOPX Gene

UniProtKB/Swiss-Prot Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for HOPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HOPX: view
genes like me logo Genes that share phenotypes with HOPX: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for HOPX Gene

Localization for HOPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOPX Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOPX Gene COMPARTMENTS Subcellular localization image for HOPX gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for HOPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17192267
genes like me logo Genes that share ontologies with HOPX: view

Pathways for HOPX Gene

SuperPathways for HOPX Gene

Superpath Contained pathways
1 HOP Signaling
genes like me logo Genes that share pathways with HOPX: view

Pathways by source for HOPX Gene

1 Qiagen pathway for HOPX Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for HOPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001829 trophectodermal cell differentiation IDA 17576768
GO:0006351 transcription, DNA-templated IEA --
GO:0007507 heart development IEA --
GO:0008016 regulation of heart contraction IEA --
genes like me logo Genes that share ontologies with HOPX: view

Transcripts for HOPX Gene

Unigene Clusters for HOPX Gene

HOP homeobox:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOPX

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOPX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for HOPX Gene

GeneLoc Exon Structure for
HOPX
ECgene alternative splicing isoforms for
HOPX

Expression for HOPX Gene

mRNA expression in normal human tissues for HOPX Gene

mRNA differential expression in normal tissues according to GTEx for HOPX Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (10.0), Skin - Not Sun Exposed (Suprapubic) (9.1), and Esophagus - Mucosa (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOPX Gene

SOURCE GeneReport for Unigene cluster for HOPX Gene Hs.619396

mRNA Expression by UniProt/SwissProt for HOPX Gene

Q9BPY8-HOP_HUMAN
Tissue specificity: Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.
genes like me logo Genes that share expressions with HOPX: view

In Situ Assay Products

Orthologs for HOPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOPX 35
  • 98.29 (n)
  • 98.72 (a)
HOPX 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOP 36
  • 66 (a)
OneToOne
HOPX 35
  • 92.24 (n)
  • 94.52 (a)
dog
(Canis familiaris)
Mammalia HOPX 35
  • 89.17 (n)
  • 88.75 (a)
HOPX 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hopx 35
  • 89.5 (n)
  • 91.78 (a)
Hopx 16
Hopx 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOPX 36
  • 23 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOPX 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hopx 35
  • 89.5 (n)
  • 91.78 (a)
chicken
(Gallus gallus)
Aves HOPX 35
  • 75.34 (n)
  • 75.34 (a)
HOPX 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOPX 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13589 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hopx 35
  • 64.22 (n)
  • 64.71 (a)
zebrafish
(Danio rerio)
Actinopterygii hopx 36
  • 45 (a)
OneToOne
Species with no ortholog for HOPX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOPX Gene

ENSEMBL:
Gene Tree for HOPX (if available)
TreeFam:
Gene Tree for HOPX (if available)

Paralogs for HOPX Gene

Selected SIMAP similar genes for HOPX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOPX: view

No data available for Paralogs for HOPX Gene

Variants for HOPX Gene

Sequence variations from dbSNP and Humsavar for HOPX Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11018 -- 56,648,108(+) TTCAA(A/G)AACTT utr-variant-3-prime
rs3184677 -- 56,648,117(-) AAACC(A/C)CCAAA utr-variant-3-prime
rs4074736 -- 56,666,179(-) GTGGG(C/G)AAGGA intron-variant
rs4074737 -- 56,665,965(-) TGCCC(C/T)TTTCA intron-variant
rs4276340 -- 56,649,581(+) ACCAC(C/T)TTACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOPX Gene

Variant ID Type Subtype PubMed ID
nsv829941 CNV Loss 17160897
nsv829942 CNV Gain 17160897
nsv4348 CNV Loss 18451855
dgv87n17 CNV Loss 16327808
nsv822560 CNV Gain 20364138
nsv10497 CNV Loss 18304495
esv2661777 CNV Deletion 23128226
esv24874 CNV Loss 19812545
nsv10498 CNV Loss 18304495
esv2659159 CNV Deletion 23128226
nsv499041 CNV Loss 21111241
nsv514214 CNV Loss 21397061
esv24352 CNV Loss 19812545
esv2421872 CNV Deletion 20811451
nsv442904 CNV CNV 18776908

Relevant External Links for HOPX Gene

HapMap Linkage Disequilibrium report
HOPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOPX Gene

Disorders for HOPX Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for HOPX Gene including...

Search for HOPX Gene in MalaCards »

(3) Novoseek inferred disease relationships for HOPX Gene

Disease -log(P) Hits PubMed IDs
choriocarcinoma 51.5 7
carcinoma squamous cell 25.7 4
tumors 0 2
genes like me logo Genes that share disorders with HOPX: view

No data available for UniProtKB/Swiss-Prot for HOPX Gene

Publications for HOPX Gene

  1. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. (PMID: 12573257) Asanoma K. … Kato H. (Genomics 2003) 3 4 23
  2. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. (PMID: 15213722) Lemaire F. … Wasylyk B. (Br. J. Cancer 2004) 3 4 23
  3. Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer. (PMID: 12759545) Chen Y. … Petersen I. (Oncology 2003) 3 4 23
  4. Analysis of the structure and function of the transcriptional coregulator HOP. (PMID: 16939210) Kook H. … Mackay J.P. (Biochemistry 2006) 3 23
  5. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. (PMID: 17192267) Kee H.J. … Kook H. (J. Biol. Chem. 2007) 3 23

Products for HOPX Gene

Sources for HOPX Gene

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