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HOPX Gene(Protein Coding)

HOP Homeobox

GCID:
GC04M056647
GIFtS:
54
Genes Participants
UDN Logo

Aliases for HOPX Gene

Aliases for HOPX Gene

  • HOP Homeobox 2 3 5
  • Lung Cancer-Associated Y Protein 3 4
  • Odd Homeobox Protein 1 3 4
  • NECC1 3 4
  • LAGY 3 4
  • HOD 3 4
  • HOP 3 4
  • OB1 3 4
  • Not Expressed In Choriocarcinoma Protein 1 4
  • Not Expressed In Choriocarcinoma Clone 1 3
  • Homeodomain-Only Protein 3
  • Homeobox Only Domain 2
  • SMAP31 3
  • CAMEO 3
  • TOTO 3

External Ids for HOPX Gene

Previous GeneCards Identifiers for HOPX Gene

  • GC04M057210
  • GC04M057514
  • GC04M053468

Summaries for HOPX Gene

Entrez Gene Summary for HOPX Gene

  • The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]

GeneCards Summary for HOPX Gene

HOPX (HOP Homeobox) is a Protein Coding gene. Diseases associated with HOPX include Choriocarcinoma and Oral Squamous Cell Carcinoma.

UniProtKB/Swiss-Prot for HOPX Gene

  • Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).

Gene Wiki entry for HOPX Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOPX Gene

Genomics for HOPX Gene

Products:

  1. Regulatory Element

Regulatory Elements for HOPX Gene

Enhancers for HOPX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G056652 1.1 Ensembl ENCODE 26 +27.1 27107 5.3 ZNF76 FEZF1 RAD21 GLIS2 GATA2 ZNF366 FOS EGR2 ZNF202 SP3 HOPX SPINK2 ENSG00000251799 LOC101928815 ENSG00000280285
GH04G056728 0.9 Ensembl ENCODE 28.2 -46.9 -46902 0.4 NR3C1 CEBPG ZNF843 ZNF518A GABPA OSR2 NFIC ATF3 ZNF692 IKZF1 HOPX ENSG00000251799 SPINK2 PIR42353 LOC285453
GH04G056640 0.8 Ensembl ENCODE 22.2 +40.2 40164 2.0 CTCF JUND JUN BHLHE40 FOS HOPX GC04P056642 GLDCP1
GH04G056648 0.5 ENCODE 24.1 +32.3 32267 2.7 CTCF ZNF512 KDM1A FOS ZNF623 HOPX ENSG00000251799 SPINK2 LOC101928815 GC04P056642
GH04G056786 0.9 Ensembl ENCODE 11.3 -105.5 -105526 1.6 FEZF1 ZIC2 NR2F2 PRDM6 ZBTB48 IKZF1 GLIS1 FOS TRIM28 ENSG00000251799 SPINK2 HOPX ENSG00000269949 GC04M056796 RN7SL492P LOC285453
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOPX on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HOPX gene promoter:

Genomic Location for HOPX Gene

Chromosome:
4
Start:
56,647,988 bp from pter
End:
56,681,899 bp from pter
Size:
33,912 bases
Orientation:
Minus strand

Genomic View for HOPX Gene

Genes around HOPX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOPX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOPX Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HOPX Gene

Proteins for HOPX Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HOPX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPY8-HOP_HUMAN
    Recommended name:
    Homeodomain-only protein
    Protein Accession:
    Q9BPY8
    Secondary Accessions:
    • A8K0Z2
    • E9PB55
    • G3V294
    • Q8N0V6
    • Q96CI1

    Protein attributes for HOPX Gene

    Size:
    73 amino acids
    Molecular mass:
    8260 Da
    Quaternary structure:
    • Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases such as HDAC2 (By similarity). Interacts with the acetylated forms of HSPA1A and HSPA1B. Interacts with HSPA8 (PubMed:27708256).

    Alternative splice isoforms for HOPX Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOPX Gene

Protein Expression for HOPX Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HOPX Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOPX Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for HOPX
  • Santa Cruz Biotechnology (SCBT) Antibodies for HOPX

No data available for DME Specific Peptides for HOPX Gene

Domains & Families for HOPX Gene

Gene Families for HOPX Gene

HGNC:

Protein Domains for HOPX Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOPX Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with HOPX: view

No data available for UniProtKB/Swiss-Prot for HOPX Gene

Function for HOPX Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HOPX Gene

UniProtKB/Swiss-Prot Function:
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256).

Gene Ontology (GO) - Molecular Function for HOPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HOPX: view
genes like me logo Genes that share phenotypes with HOPX: view

Animal Models for HOPX Gene

MGI Knock Outs for HOPX:

Animal Model Products

  • Taconic Biosciences Mouse Models for HOPX

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOPX Gene

Localization for HOPX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOPX Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOPX gene
Compartment Confidence
nucleus 5
extracellular 2
plasma membrane 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for HOPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 17192267
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HOPX: view

Pathways & Interactions for HOPX Gene

SuperPathways for HOPX Gene

PathCards logo More details on SuperPathways for HOPX
No Data Available

Gene Ontology (GO) - Biological Process for HOPX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001829 trophectodermal cell differentiation IDA 17576768
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with HOPX: view

No data available for Pathways by source and SIGNOR curated interactions for HOPX Gene

Drugs & Compounds for HOPX Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for HOPX Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HOPX Gene

(13) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(338) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOPX Gene

HOP homeobox:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOPX Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for HOPX Gene

GeneLoc Exon Structure for
HOPX
ECgene alternative splicing isoforms for
HOPX

Expression for HOPX Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOPX Gene

mRNA expression in normal human tissues for HOPX Gene
mRNA expression by BioGPS for HOPX GenemRNA expression by GTEx for HOPX Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOPX Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x10.0), Skin - Not Sun Exposed (Suprapubic) (x9.1), and Esophagus - Mucosa (x5.5).

Protein differential expression in normal tissues from HIPED for HOPX Gene

This gene is overexpressed in Skin (13.0), Oral epithelium (11.8), Esophagus (6.6), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOPX Gene



NURSA nuclear receptor signaling pathways regulating expression of HOPX Gene:

HOPX

SOURCE GeneReport for Unigene cluster for HOPX Gene:

Hs.619396

mRNA Expression by UniProt/SwissProt for HOPX Gene:

Q9BPY8-HOP_HUMAN
Tissue specificity: Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma.

Evidence on tissue expression from TISSUES for HOPX Gene

  • Nervous system(4.9)
  • Heart(4.4)
  • Skin(3.5)
  • Lung(2.6)
  • Thyroid gland(2.3)
  • Intestine(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with HOPX: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOPX Gene

Orthologs for HOPX Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOPX Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia HOPX 34 35
  • 98.29 (n)
cow
(Bos Taurus)
 Mammalia HOPX 34
  • 92.24 (n)
HOP 35
  • 66 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Hopx 34 16 35
  • 89.5 (n)
rat
(Rattus norvegicus)
 Mammalia Hopx 34
  • 89.5 (n)
dog
(Canis familiaris)
 Mammalia HOPX 34 35
  • 89.17 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia HOPX 35
  • 51 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia HOPX 35
  • 23 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HOPX 34 35
  • 75.34 (n)
lizard
(Anolis carolinensis)
 Reptilia HOPX 35
  • 58 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia hopx 34
  • 64.22 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.13589 34
zebrafish
(Danio rerio)
 Actinopterygii hopx 35
  • 45 (a)
 OneToOne
Species where no ortholog for HOPX was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOPX Gene

ENSEMBL:
Gene Tree for HOPX (if available)
TreeFam:
Gene Tree for HOPX (if available)

Paralogs for HOPX Gene

(6) SIMAP similar genes for HOPX Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOPX: view

No data available for Paralogs for HOPX Gene

Variants for HOPX Gene

Sequence variations from dbSNP and Humsavar for HOPX Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs11555052 Likely benign 56,655,968(-) ACAGA(A/G)GACCA intron-variant, reference, synonymous-codon
rs483353075 Uncertain significance 56,655,931(+) GTCGA(C/T)CTTGT intron-variant, reference, missense
rs1000040971 -- 56,649,886(+) AAACA(A/G)CTTTG intron-variant, utr-variant-3-prime
rs1000187458 -- 56,675,254(+) CAGAA(C/T)GAGGA intron-variant
rs1000190271 -- 56,656,181(+) CTTAC(A/G)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOPX Gene

Variant ID Type Subtype PubMed ID
dgv87n17 CNV loss 16327808
esv2421872 CNV deletion 20811451
esv24352 CNV loss 19812545
esv24874 CNV loss 19812545
esv2659159 CNV deletion 23128226
esv2661777 CNV deletion 23128226
esv2760862 CNV loss 21179565
esv3600582 CNV loss 21293372
esv3600583 CNV loss 21293372
nsv1000406 CNV loss 25217958
nsv1004737 CNV loss 25217958
nsv1005968 CNV gain 25217958
nsv1007222 CNV loss 25217958
nsv1014355 CNV loss 25217958
nsv10497 CNV loss 18304495
nsv10498 CNV loss 18304495
nsv1161087 CNV duplication 26073780
nsv1161088 CNV duplication 26073780
nsv4348 CNV deletion 18451855
nsv442904 CNV loss 18776908
nsv499041 CNV loss 21111241
nsv514214 CNV loss 21397061
nsv822560 CNV gain 20364138
nsv829941 CNV loss 17160897
nsv829942 CNV gain 17160897
nsv999750 CNV gain 25217958

Variation tolerance for HOPX Gene

Residual Variation Intolerance Score: 57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.10; 51.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOPX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOPX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOPX Gene

Disorders for HOPX Gene

MalaCards: The human disease database

(3) MalaCards diseases for HOPX Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
choriocarcinoma
  • chorioepithelioma
oral squamous cell carcinoma
  • mouth squamous cell carcinoma
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search HOPX in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOPX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOPX
genes like me logo Genes that share disorders with HOPX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOPX Gene

Publications for HOPX Gene

  1. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. (PMID: 15213722) Lemaire F. … Wasylyk B. (Br. J. Cancer 2004) 3 4 22 64
  2. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. (PMID: 12573257) Asanoma K. … Kato H. (Genomics 2003) 3 4 22 64
  3. Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer. (PMID: 12759545) Chen Y. … Petersen I. (Oncology 2003) 3 4 22 64
  4. ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation. (PMID: 27708256) Seo J.H. … Kim K.W. (Nat. Commun. 2016) 3 4 64
  5. HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma. (PMID: 18234960) Yamashita K. … Sidransky D. (Mol. Cancer Res. 2008) 3 22 64

Products for HOPX Gene

Sources for HOPX Gene

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