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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOPX Gene

protein-coding   GIFtS: 47
GCID: GC04M057514

HOP homeobox
 Explore 16 diseases affiliated with
HOPX via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOPX    

Aliases
for HOPX gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
HOP Homeobox1 2     Odd Homeobox Protein 12 3
HOP1 2 3 5     HOD2 3
LAGY1 2 3     CAMEO2
NECC11 2 3     TOTO2
OB11 2 3     Homeodomain-Only Protein2
SMAP311 2     Not Expressed In Choriocarcinoma Clone 12
Lung Cancer-Associated Y Protein2 3     Odd Homeobox 1 Protein2
Not Expressed In Choriocarcinoma Protein 12 3     

External Ids:    HGNC: 249611   Entrez Gene: 845252   Ensembl: ENSG000001714767   OMIM: 6072755   UniProtKB: Q9BPY83   

Export aliases for HOPX gene to outside databases

Previous GC identifers: GC04M057210 GC04M053468


Summaries
for HOPX gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOPX:
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA
binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the
possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this
protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and
cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. (provided
by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and
development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific
genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by
recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac
hypertrophy (By similarity). May act as a tumor suppressor

Gene Wiki entry for HOPX


Genomic Views
for HOPX gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022853.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOPX gene promoter:
         Max1   FOXD3   AREB6   Egr-2   MEF-2A   S8   Ik-2   aMEF-2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOPX promoter sequence
   Search SABiosciences Chromatin IP Primers for HOPX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOPX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

HOPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOPX gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M057514:  view genomic region     (about GC identifiers)

Start:
 57,514,154 bp from pter      End:
 57,548,065 bp from pter
Size:
 33,912 bases      Orientation:
 minus strand

Proteins
for HOPX gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8 (See protein sequence)
Recommended Name: Homeodomain-only protein  
Size: 73 amino acids; 8260 Da
Subunit: Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases such
as HDAC2 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8K0Z2 Q8N0V6 Q96CI1
Alternative splicing: 2 isoforms:  Q9BPY8-1   Q9BPY8-2   

Explore the universe of human proteins at neXtProt for HOPX: NX_Q9BPY8

HOPX Protein expression data from MOPED and PaxDb: --

REFSEQ proteins (5 alternative transcripts): 
NP_001138931.1  NP_001138932.1  NP_115884.4  NP_631957.1  NP_631958.1  

ENSEMBL proteins: 
 ENSP00000422175   ENSP00000451794   ENSP00000452340   ENSP00000370659   ENSP00000370654  
 ENSP00000315198   ENSP00000424101   ENSP00000422083   ENSP00000337330   ENSP00000452098  
 ENSP00000452003   ENSP00000421831   ENSP00000421272   ENSP00000423239   ENSP00000451631  
 ENSP00000396275   ENSP00000450527  

Human Recombinant Protein Products: 
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OriGene Purified Protein: HOPX
OriGene Protein Over-expression Lysate (see all 6): HOPX
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Novus Biologicals HOPX Proteins
Novus Biologicals HOPX Lysates
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for HOPX
Uscn Proteins for HOPX

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA17192267


HOPX for ontologies           About GeneDecksing



HOPX Antibody Products: 
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Uscn Antibodies for HOPX
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Assay Products for HOPX: 
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GenScript Custom Assay Services for HOPX
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Uscn ELISAs and CLIAs for HOPX

Protein Domains /
Families
for HOPX gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HOPX for domains           About GeneDecksing

2 InterPro domains/families:
 IPR001356 Homeodomain
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9BPY8

ProtoNet protein and cluster: Q9BPY8

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Similarity: Contains 1 homeobox DNA-binding domain


Function
for HOPX gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and
development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific
genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by
recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac
hypertrophy (By similarity). May act as a tumor suppressor

miRNA
Products:    		 OriGene 3'-UTR Clone (see all 5): HOPX
Browse MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOPX
7 QIAGEN miScript miRNA Assays for microRNAs that regulate HOPX:
hsa-miR-548p hsa-miR-3152-3p hsa-miR-493* hsa-miR-586 hsa-miR-3924 hsa-miR-1286 hsa-miR-1305
SwitchGear 3'UTR luciferase reporter plasmid: HOPX 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOPX (see all 4)
OriGene shRNA RFP: HOPX
OriGene siRNA: HOPX
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOPX

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for HOPX

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOPX (see all 10)
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 5): HOPX (NM_139211)
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DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOPX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOPX 

Cell Line
Products:     		GenScript Custom overexpressing Cell Line Services for HOPX
Search LifeMap BioReagents cell lines for HOPX

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOPX

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding ----
GO:0043565sequence-specific DNA binding IEA--


HOPX for ontologies           About GeneDecksing


Animal Models:
     8 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Hopx):
 cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  mortality/aging 
 muscle  no phenotypic analysis  respiratory system 

HOPX for phenotypes           About GeneDecksing


Pathways & Interactions
for HOPX gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOPX

5/8 Interacting proteins for HOPX (Q9BPY83) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
HDAC2Q927693I2D: score=2 
SRFP118313I2D: score=2 
AGTP010193I2D: score=1 
EPC1Q9H2F53I2D: score=1 
GZMBP101443I2D: score=1 
About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
GO:0001829trophectodermal cell differentiation IDA17576768
GO:0006351transcription, DNA-dependent IEA--
GO:0007507heart development ----
GO:0008016regulation of heart contraction ----


HOPX for ontologies           About GeneDecksing



Drugs & Compounds
for HOPX gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HOPX
Search CenterWatch for drugs/clinical trials and news about HOPX / HOP 

Transcripts
for HOPX gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for HOPX gene (5 alternative transcripts): 
NM_001145459.1  NM_001145460.1  NM_032495.5  NM_139211.4  NM_139212.3  

Unigene Cluster for HOPX:

HOP homeobox
Hs.619396  [show with all ESTs]
Unigene Representative Sequence: NM_001145460
17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000508121 ENST00000556376 ENST00000553379 ENST00000381260 ENST00000381255
ENST00000317745 ENST00000503639(uc011cad.1 uc003hbz.2) ENST00000503864
ENST00000337881 ENST00000555760 ENST00000556614 ENST00000509435 ENST00000514890
ENST00000506661 ENST00000557328 ENST00000420433(uc003hca.2 uc003hcb.2 uc003hce.2)
ENST00000554144(uc003hcc.2 uc003hcd.2)

miRNA
Products:     		 OriGene 3'-UTR Clone (see all 5): HOPX
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOPX
7 QIAGEN miScript miRNA Assays for microRNAs that regulate HOPX:
hsa-miR-548p hsa-miR-3152-3p hsa-miR-493* hsa-miR-586 hsa-miR-3924 hsa-miR-1286 hsa-miR-1305
SwitchGear 3'UTR luciferase reporter plasmid: HOPX 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOPX (see all 4)
OriGene shRNA RFP: HOPX
OriGene siRNA: HOPX
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOPX
Clone
Products:     		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOPX (see all 10)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOPX (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector (see all 5): HOPX (NM_139211)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOPX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOPX 
Primer
Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOPX
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOPX
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOPX
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOPX

Additional cDNA sequence: 

AB019573.1 AB059408.1 AB059409.1 AB059410.2 AF454763.1 AF492675.1 AF492676.1 AF492677.1 
AF492678.1 AF492679.1 AF492680.1 AF492681.1 AK289707.1 BC014225.2 

20 DOTS entries:

DT.100037000  DT.218114  DT.100820613  DT.100820616  DT.100820612  DT.100820615  DT.100036998  DT.91768126 
DT.99939376  DT.100820611  DT.100820614  DT.91727497  DT.95164814  DT.100036997  DT.121238333  DT.95164815 
DT.121238299  DT.97779431  DT.97857570  DT.95227952 

24/338 AceView cDNA sequences (see all 338):

NM_032495 BM561983 BU689204 AA828485 BQ029097 BM561848 AA152031 AA922773 
BG202366 BG197750 BG220659 AW469993 AA781840 BG196719 BG183252 AI190863 
AA412667 AA251832 AI201538 AB059408 AB059409 F04641 AA504137 CA438939 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for HOPX (see all 6)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1:              -     -     -     -                                             
SP2:              -     -     -     -           -                                 
SP3:                                -           -                                 
SP4:                                -           -                                 
SP5:                                            -                                 


ECgene alternative splicing isoforms for HOPX

Expression
for HOPX gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HOPX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGACAGATG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

HOPX expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
7 LifeMap In Vivo Development Anatomical Compartments/Cells 
Tissue Anatomical Compartment CellCategory (developmental path)
HeartCardiac CrescentCardiac Crescent CellsMyocardium
HeartHeart TubeHeart Tube CellsMyocardium
HeartMyocardiumCardiomyocytesMyocardium
HeartPrimitive Heart TubePrimitive Heart Tube CellsMyocardium
BrainMedulla OblongataBrain
Neural TubeMetencephalonNeural Tube
Spinal CordPresumptive Spinal CordSpinal Cord
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/12 LifeMap Cells (see all 12) 
NameCategory
PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
PureStem™ progenitor EN13 (Embryonic Progenitor Cell)
PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
Syncytiotrophoblast-like cells (Generation of syncyt...)
HyStem+BMP4-induced SM30 cells (HyStem+BMP4 inductio...)Adipose, Bone, Cartilage
HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose
HyStem+TGF?3+GDF5-induced 7PEND24 cells (HyStem+TGF?3+GDF5 in...)Bone

Genevestigator expression for HOPX

SOURCE GeneReport for Unigene cluster: Hs.619396

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Tissue specificity: Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles,
uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer,
choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma

    SABiosciences Expression via Pathway-Focused PCR Arrays including HOPX: 
          T Helper Cell Differentiation in human mouse rat
          Cellular Stress Responses in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOPX
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOPX
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOPX
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOPX

Orthologs
for HOPX gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for HOPX gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
mouse
(Mus musculus)		 Mammalia Hopx1 , 5 HOP homeobox1, 5 89.5(n)1
91.78(a)1		   5 (41.45 cM)5
743181  NM_001159900.11  NP_001153372.11 
 770864435 
chicken
(Gallus gallus)		 Aves HOPX1 HOP homeobox 75.34(n)
75.34(a)		   395241  NM_204556.1  NP_989887.1 
lizard
(Anolis carolinensis)		 Reptilia HOPX6
 --
 58(a)
 1 ↔ 1
 GL343257.1(1647596-1653639)
African clawed frog
(Xenopus laevis)		 Amphibia Xl.135892 Xenopus laevis transcribed sequence with weak similarity more 73.96(n)    BJ070536.1 
zebrafish
(Danio rerio)		 Actinopterygii hopx6
 HOP homeobox
 49(a)
 1 ↔ 1
 14(1176147-1183521)


ENSEMBL Gene Tree for HOPX (if available)
TreeFam Gene Tree for HOPX (if available) 

Paralogs
for HOPX gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

Genomic Variants
for HOPX gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for HOPX
     8 CNVs: 37428 37962 63825 1078 63826 32605 36284 92113
     2 Indels: 33759 92112
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOPX
DNA2.0 Custom Variant and Variant Library Synthesis for HOPX

Disorders / Diseases
for HOPX gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
HOPX for disorders           About GeneDecksing

OMIM gene information: 607275    OMIM disorders: --

16 diseases for HOPX:    About MalaCards
choriocarcinoma    lung cancer    actinomycosis    squamous cell carcinoma
oral squamous cell carcinoma    esophageal squamous cell carcinoma    nevus    dilated cardiomyopathy
cardiomyopathy    endometrial cancer    thyroid carcinoma    carcinoma
esophagitis    gastric cancer    thyroiditis    glioblastoma

3 Novoseek disease relationships for HOPX gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma 51.5 9 12573257 (4), 15457851 (3)
carcinoma squamous cell 25.7 5 15213722 (2), 18234960 (1), 12759545 (1)
tumors 0 4 7796812 (1), 18234960 (1)


Export disorders for HOPX gene to outside databases

Publications
for HOPX gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HOPX gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with HOPX)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer. (PubMed id 12759545)1, 2, 9 Chen Y.... Petersen I. (2003)
  2. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. (PubMed id 12573257)1, 2, 9 Asanoma K.... Kato H. (2003)
  3. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. (PubMed id 15213722)1, 2, 9 Lemaire F....Wasylyk B. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  6. Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. (PubMed id 15381369)1, 2 Toruner G.A.... Dermody J.J. (2004)
  7. Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development. (PubMed id 14516659)1, 2 Adu J.... Mighell A.J. (2002)
  8. Hop is an unusual homeobox gene that modulates cardiac development. (PubMed id 12297045)1, 3 Chen F....Epstein J.A. (2002)
  9. Analysis of the structure and function of the transcriptional coregulator HOP. (PubMed id 16939210)1, 9 Kook H....Mackay J.P. (2006)
  10. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. (PubMed id 17192267)1, 9 Kee H.J....Kook H. (2007)

External Searches for HOPX gene

(in PubMed, OMIM, and NCBI Bookshelf)
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Genome Databases showing HOPX gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84525 HGNC: 24961 AceView: HOP Ensembl:ENSG00000171476 euGenes: HUgn84525
ECgene: HOPX H-InvDB: HOPX

Other Databases showing HOPX gene

(According to HUGE)
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Specialized Databases showing HOPX gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HOPX Pharmacogenomics, SNPs, Pathways

Intellectual Property
for HOPX gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HOPX gene:
Search GeneIP for patents involving HOPX

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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