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HOPX Gene

protein-coding   GIFtS: 45
GCID: GC04M057514

HOP Homeobox

  See HOPX-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
HOP Homeobox1 2     OB12 3
HOP2 3 5     Homeobox Only Domain1
Lung Cancer-Associated Y Protein2 3     CAMEO2
Not Expressed In Choriocarcinoma Protein 12 3     SMAP312
Odd Homeobox Protein 12 3     TOTO2
HOD2 3     Homeodomain-Only Protein2
LAGY2 3     Not Expressed In Choriocarcinoma Clone 12
NECC12 3     Odd Homeobox 1 Protein2

External Ids:    HGNC: 249611   Entrez Gene: 845252   Ensembl: ENSG000001714767   OMIM: 6072755   UniProtKB: Q9BPY83   

Export aliases for HOPX gene to outside databases

Previous GC identifers: GC04M057210 GC04M053468


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOPX Gene:
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA
binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested
the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest
that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene
expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for
this gene. (provided by RefSeq, Feb 2009)

GeneCards Summary for HOPX Gene:
HOPX (HOP homeobox) is a protein-coding gene. Diseases associated with HOPX include choriocarcinoma, and lung cancer. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and
development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent
cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF
binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF.
Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor

Gene Wiki entry for HOPX Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_022853.16  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOPX gene promoter:
         Max1   FOXD3   AREB6   Egr-2   MEF-2A   S8   Ik-2   aMEF-2   Pax-4a   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOPX promoter sequence
   Search Chromatin IP Primers for HOPX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOPX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

HOPX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOPX gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M057514:  view genomic region     (about GC identifiers)

Start:
57,514,154 bp from pter      End:
57,548,065 bp from pter
Size:
33,912 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8 (See protein sequence)
Recommended Name: Homeodomain-only protein  
Size: 73 amino acids; 8260 Da
Subunit: Interacts with serum response factor (SRF). Component of a large complex containing histone deacetylases
such as HDAC2 (By similarity)
Secondary accessions: A8K0Z2 E9PB55 G3V294 Q8N0V6 Q96CI1
Alternative splicing: 4 isoforms:  Q9BPY8-1   Q9BPY8-2   Q9BPY8-3   Q9BPY8-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for HOPX: NX_Q9BPY8

Explore proteomics data for HOPX at MOPED


See HOPX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts): 
NP_001138931.1  NP_001138932.1  NP_115884.4  NP_631957.1  NP_631958.1  

ENSEMBL proteins: 
 ENSP00000422175   ENSP00000424101   ENSP00000452340   ENSP00000370654   ENSP00000315198  
 ENSP00000452098   ENSP00000452003   ENSP00000451794   ENSP00000370659   ENSP00000337330  
 ENSP00000451631   ENSP00000396275   ENSP00000450527  

HOPX Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for HOPX
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Novus Biologicals HOPX Proteins
Novus Biologicals HOPX Lysates
Browse Sino Biological Recombinant Proteins
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ProSpec Recombinant Protein for HOPX
Browse Proteins at Cloud-Clone Corp.

 
Search eBioscience for Proteins for HOPX 

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LSBio Antibodies in human, mouse, rat for HOPX

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Search eBioscience for ELISAs for HOPX 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
PRD: Homeoboxes / PRD class

2 InterPro protein domains:
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q9BPY8

ProtoNet protein and cluster: Q9BPY8

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Similarity: Contains 1 homeobox DNA-binding domain


Find genes that share domains with HOPX           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: HOP_HUMAN, Q9BPY8
Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and
development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent
cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF
binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF.
Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity IEA--
GO:0005515protein binding ----
GO:0043565sequence-specific DNA binding IEA--
     
Find genes that share ontologies with HOPX           About GenesLikeMe


Phenotypes:
     8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Hopx):
 cardiovascular system  cellular  embryogenesis  homeostasis/metabolism  mortality/aging 
 muscle  no phenotypic analysis  respiratory system 

Find genes that share phenotypes with HOPX           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOPX
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOPX

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOPX
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOPX

miRNA
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Block miRNA regulation of human, mouse, rat HOPX using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate HOPX:
hsa-miR-548p hsa-miR-3152-3p hsa-miR-493* hsa-miR-586 hsa-miR-3924 hsa-miR-1286 hsa-miR-1305
SwitchGear 3'UTR luciferase reporter plasmidHOPX 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for HOPX
Predesigned siRNA for gene silencing in human, mouse, rat HOPX

Gene Editing
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DNA2.0 Custom Protein Engineering Service for HOPX

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GenScript: all cDNA clones in your preferred vector (see all 5): HOPX (NM_139211)
Sino Biological Human cDNA Clone for HOPX
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOPX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOPX

Cell Line
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GenScript Custom overexpressing Cell Line Services for HOPX
Browse ESI BIO Cell Lines and PureStem Progenitors for HOPX 
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOPX

Flow Cytometry
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eBioscience FlowRNA Probe Sets ( VA1-12410) for HOPX 


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
HOP_HUMAN, Q9BPY8: Nucleus (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
extracellular2
cytosol1
mitochondrion1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IDA17192267

Find genes that share ontologies with HOPX           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for HOPX
    HOP Signaling



    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOPX: 
          T Helper Cell Differentiation in human mouse rat
          Cellular Stress Responses in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for HOPX

Selected Interacting proteins for HOPX (Q9BPY83) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
InteractantInteraction Details
GeneCardExternal ID(s)
HDAC2Q927693I2D: score=2 
SRFP118313I2D: score=2 
AGTP010193I2D: score=1 
EPC1Q9H2F53I2D: score=1 
GZMBP101443I2D: score=1 
About this table

Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0001829trophectodermal cell differentiation IDA17576768
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated ----
GO:0007507heart development IEA--

Find genes that share ontologies with HOPX           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for HOPX (HOP)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for HOPX gene (5 alternative transcripts): 
NM_001145459.1  NM_001145460.1  NM_032495.5  NM_139211.4  NM_139212.3  

Unigene Cluster for HOPX:

HOP homeobox
Hs.619396  [show with all ESTs]
Unigene Representative Sequence: NM_001145460
16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000508121 ENST00000503639(uc011cad.1 uc003hbz.2) ENST00000553379
ENST00000381255 ENST00000317745 ENST00000555760 ENST00000556614 ENST00000556376
ENST00000381260 ENST00000337881 ENST00000503864 ENST00000557328 ENST00000605395
ENST00000506661 ENST00000420433(uc003hca.2 uc003hcb.2 uc003hce.2)
ENST00000554144(uc003hcc.2 uc003hcd.2)
miRNA
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Block miRNA regulation of human, mouse, rat HOPX using miScript Target Protectors
7 qRT-PCR Assays for microRNAs that regulate HOPX:
hsa-miR-548p hsa-miR-3152-3p hsa-miR-493* hsa-miR-586 hsa-miR-3924 hsa-miR-1286 hsa-miR-1305
SwitchGear 3'UTR luciferase reporter plasmidHOPX 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for HOPX
Predesigned siRNA for gene silencing in human, mouse, rat HOPX
Clone
Products:
     
OriGene clones in human, mouse for HOPX (see all 30)
OriGene ORF clones in mouse, rat for HOPX
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 5): HOPX (NM_139211)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOPX
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOPX
Primer
Products:
    
OriGene qPCR primer pairs and template standards for HOPX
OriGene qSTAR qPCR primer pairs in human, mouse for HOPX
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOPX
  QuantiTect SYBR Green Assays in human, mouse, rat HOPX
  QuantiFast Probe-based Assays in human, mouse, rat HOPX
Flow Cytometry
Products:
   

 
eBioscience FlowRNA Probe Sets ( VA1-12410) for HOPX 

Additional mRNA sequence: 

AB019573.1 AB059408.1 AB059409.1 AB059410.2 AF454763.1 AF492675.1 AF492676.1 AF492677.1 
AF492678.1 AF492679.1 AF492680.1 AF492681.1 AK289707.1 BC014225.2 

20 DOTS entries:

DT.100037000  DT.218114  DT.100820613  DT.100820616  DT.100820612  DT.100820615  DT.100036998  DT.91768126 
DT.99939376  DT.100820611  DT.100820614  DT.91727497  DT.95164814  DT.100036997  DT.121238333  DT.95164815 
DT.121238299  DT.97779431  DT.97857570  DT.95227952 

Selected AceView cDNA sequences (see all 338):

BQ286118 CA943185 AW593806 CR626269 AB059408 BG208648 AA781840 AK023748 
BG190634 BI754546 AA588028 AK123318 BQ287814 AA828485 NM_032495 NM_139211 
BG054836 AI683579 AA936977 BG183252 BG220659 AA991473 AL543923 AA412667 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for HOPX (see all 6)    About this scheme

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1:              -     -     -     -                                             
SP2:              -     -     -     -           -                                 
SP3:                                -           -                                 
SP4:                                -           -                                 
SP5:                                            -                                 


ECgene alternative splicing isoforms for HOPX

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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HOPX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATGACAGATG
HOPX Expression
About this image


HOPX expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 13) fully expand
 
 Bone (Muscoskeletal System)    fully expand to see all 9 entries
         HyStem+BMP4-induced 4D20.8 cells
 
 Cartilage (Muscoskeletal System)    fully expand to see all 8 entries
         HyStem+BMP4-induced 4D20.8 cells
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Mature Choroid Plexus Cells Choroid Plexus
         Medulla Oblongata
         N2/LSB/S/F8-induced cells
 
 Adipose (Muscoskeletal System)    fully expand to see all 3 entries
         HyStem+BMP4-induced E15 cells
 
 Epithelial Cells
         Mature Choroid Plexus Cells Choroid Plexus
HOPX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

HOPX Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.619396

UniProtKB/Swiss-Prot: HOP_HUMAN, Q9BPY8
Tissue specificity: Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles,
uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer,
choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma

    Pathway & Disease-focused RT2 Profiler PCR Arrays including HOPX: 
          T Helper Cell Differentiation in human mouse rat
          Cellular Stress Responses in human mouse rat
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for HOPX
OriGene qSTAR qPCR primer pairs in human, mouse for HOPX
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOPX
QuantiTect SYBR Green Assays in human, mouse, rat HOPX
QuantiFast Probe-based Assays in human, mouse, rat HOPX
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOPX

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for HOPX gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Hopx1 , 5 HOP homeobox1, 5 89.5(n)1
91.78(a)1
  5 (41.45 cM)5
743181  NM_001159901.11  NP_001153373.11 
 770869885 
chicken
(Gallus gallus)
Aves HOPX1 HOP homeobox 75.34(n)
75.34(a)
  395241  NM_204556.1  NP_989887.1 
lizard
(Anolis carolinensis)
Reptilia HOPX6
HOP homeobox
58(a)
1 ↔ 1
GL343257.1(1647596-1653639)
African clawed frog
(Xenopus laevis)
Amphibia Xl.135892 Xenopus laevis transcribed sequence with weak similarity more 73.96(n)    BJ070536.1 
zebrafish
(Danio rerio)
Actinopterygii hopx6
HOP homeobox
45(a)
1 ↔ 1
14(1176147-1183521) ENSDARG00000089368


ENSEMBL Gene Tree for HOPX (if available)
TreeFam Gene Tree for HOPX (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for HOPX gene
6 SIMAP similar genes for HOPX using alignment to 2 protein entries:     HOP_HUMAN (see all proteins):
PITX2    PITX1    PAX4    DRGX    PAX6    NOBOX

Find genes that share paralogs with HOPX           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for HOPX (see all 761)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs753843231,2
F--57513667(+) GTAATC/ACCATT 5 -- ds50011Minor allele frequency- A:0.05WA 118
rs623082451,2
C,F--57513737(+) CCACCT/ATAGGG 5 -- ds50015Minor allele frequency- A:0.15NA WA EA 362
rs1424402101,2
C--57513777(+) GGGCC-/GGGGT 
 GTGGGCG
GGGGG
5 -- ds50010--------
rs3763171701,2
C--57513777(+) GGGCCA/GGGGTG 5 -- ds50010--------
rs738182141,2
C--57513788(+) TGGGCG/CGGGGG 5 -- ds50011Minor allele frequency- C:0.50WA 2
rs119440141,2
C,F,H--57513910(+) taaacC/Tgcttg 5 -- ds500111Minor allele frequency- T:0.02NS EA NA CSA 1098
rs126491541,2
C,F,H--57513912(+) AACCGC/ATTGAG 5 -- ds500121Minor allele frequency- A:0.12NS EA NA WA CSA 2340
rs1859422621,2
--57514280(+) AACTTC/TGGTGG 5 -- ut310--------
rs31846771,2
C,A--57514283(-) AAACCA/CCCAAA 5 -- ut31 ese32Minor allele frequency- C:0.02MN NA 186
rs1167401861,2
C,F--57514335(+) TCTTCT/CGGCCC 5 -- ut311Minor allele frequency- C:0.01NA 120

HapMap Linkage Disequilibrium report for HOPX (57514154 - 57548065 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for HOPX (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2659159CNV Deletion23128226
esv2421872CNV Deletion20811451
esv2661777CNV Deletion23128226
nsv10498CNV Loss18304495
nsv514214CNV Loss21397061
nsv829941CNV Loss17160897
esv24874CNV Loss19812545
nsv499041CNV Loss21111241
esv24352CNV Loss19812545
dgv87n17CNV Loss16327808

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607275    OMIM disorders: --

2 diseases for HOPX:    
About MalaCards
choriocarcinoma    lung cancer


Find genes that share disorders with HOPX           About GenesLikeMe

3 Novoseek inferred disease relationships for HOPX gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
choriocarcinoma 51.5 9 12573257 (4), 15457851 (3)
carcinoma squamous cell 25.7 5 15213722 (2), 18234960 (1), 12759545 (1)
tumors 0 4 7796812 (1), 18234960 (1)


Export disorders for HOPX gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for HOPX gene, integrated from 10 sources (see all 47):
(articles sorted by number of sources associating them with HOPX)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel homeobox-containing gene, LAGY, which is downregulated in lung cancer. (PubMed id 12759545)1, 2, 9 Chen Y.... Petersen I. (Oncology 2003)
  2. NECC1, a candidate choriocarcinoma suppressor gene that encodes a homeodomain consensus motif. (PubMed id 12573257)1, 2, 9 Asanoma K.... Kato H. (Genomics 2003)
  3. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. (PubMed id 15213722)1, 2, 9 Lemaire F....Wasylyk B. (Br. J. Cancer 2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Association between gene expression profile and tumor invasion in oral squamous cell carcinoma. (PubMed id 15381369)1, 2 Toruner G.A.... Dermody J.J. (Cancer Genet. Cytogenet. 2004)
  7. Expression of mOb1, a novel atypical 73 amino acid K50-homeodomain protein, during mouse development. (PubMed id 14516659)1, 2 Adu J.... Mighell A.J. (Mech. Dev. 2002)
  8. Hop is an unusual homeobox gene that modulates cardiac development. (PubMed id 12297045)1, 3 Chen F....Epstein J.A. (Cell 2002)
  9. Analysis of the structure and function of the transcriptional coregulator HOP. (PubMed id 16939210)1, 9 Kook H....Mackay J.P. (Biochemistry 2006)
  10. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. (PubMed id 17192267)1, 9 Kee H.J....Kook H. (J. Biol. Chem. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84525 HGNC: 24961 AceView: HOP Ensembl:ENSG00000171476 euGenes: HUgn84525
ECgene: HOPX H-InvDB: HOPX

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for HOPX Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for HOPX gene:
Search GeneIP for patents involving HOPX

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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