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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOOK3 Gene

protein-coding   GIFtS: 52
GCID: GC08P042769

Hook Microtubule-Tethering Protein 3

(Previous name: hook homolog 3 (Drosophila))
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hook Microtubule-Tethering Protein 31 2     Hook Homolog 3 (Drosophila)1
h-hook32 3     Hook Homolog 32
hHK32 3     Protein Hook Homolog 32
HK32 5     

External Ids:    HGNC: 235761   Entrez Gene: 843762   Ensembl: ENSG000001681727   OMIM: 6078255   UniProtKB: Q86VS83   

Export aliases for HOOK3 gene to outside databases

Previous GC identifers: GC12M9A0079 GC08P042821 GC08P042492 GC08P042871 GC08P041277


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOOK3 Gene:
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to
microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook
protein is a component of the endocytic compartment.(supplied by OMIM, Apr 2004)

GeneCards Summary for HOOK3 Gene: 
HOOK3 (hook microtubule-tethering protein 3) is a protein-coding gene. Diseases associated with HOOK3 include papillary thyroid carcinoma, and thyroiditis. GO annotations related to this gene include microtubule binding and identical protein binding. An important paralog of this gene is HOOK2.

UniProtKB/Swiss-Prot: HOOK3_HUMAN, Q86VS8
Function: Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it,
leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex
(FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic
vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as
MSR1. Participates in defining the architecture and localization of the Golgi complex

Gene Wiki entry for HOOK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOOK3 gene promoter:
         STAT5B   STAT1   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   PPAR-alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOOK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOOK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOOK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.21   Ensembl cytogenetic band:  8p11.21   HGNC cytogenetic band: 8p11.21

HOOK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOOK3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P042769:  view genomic region     (about GC identifiers)

Start:
42,752,033 bp from pter      End:
42,885,682 bp from pter
Size:
133,650 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HOOK3_HUMAN, Q86VS8 (See protein sequence)
Recommended Name: Protein Hook homolog 3  
Size: 718 amino acids; 83126 Da
Subunit: Interacts with Salmonella typhimurium spiC (By similarity). Self-associates. Component of the
FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family
of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK2. Associates with
several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these
interactions may be indirect. Interacts with MSR1, and this association is stimulated by ligand binding to MSR1.
Interacts with microtubules
Subcellular location: Cytoplasm, cytoskeleton. Golgi apparatus. Note=Enriched at the cis-face of the Golgi complex
(By similarity). Localizes to microtubule asters in prophase (By similarity)
Sequence caution: Sequence=AAH48304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: D3DSY8 Q8NBH0 Q9BY13

Explore the universe of human proteins at neXtProt for HOOK3: NX_Q86VS8

Explore proteomics data for HOOK3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VS8

  • HOOK3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOOK3 Protein Expression
    REFSEQ proteins: NP_115786.1  
    ENSEMBL proteins: 
     ENSP00000305699   ENSP00000435077   ENSP00000433953   ENSP00000433813  

    Human Recombinant Protein Products for HOOK3: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for HOOK3 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material ISS--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005801cis-Golgi network IDA11238449
    GO:0005813centrosome ISS--

    HOOK3 for ontologies           About GeneDecksing



    HOOK3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008636 HOOK/CCDC88

    Graphical View of Domain Structure for InterPro Entry Q86VS8

    ProtoNet protein and cluster: Q86VS8

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB008636 HOOK


    UniProtKB/Swiss-Prot: HOOK3_HUMAN, Q86VS8
    Similarity: Belongs to the hook family


    HOOK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HOOK3_HUMAN, Q86VS8
    Function: Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it,
    leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex
    (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic
    vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as
    MSR1. Participates in defining the architecture and localization of the Golgi complex

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17237231
    GO:0008017microtubule binding IDA11238449
    GO:0042802identical protein binding IPI18799622
         
    HOOK3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOOK3:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for HOOK3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOOK3 
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    8/170 QIAGEN miScript miRNA Assays for microRNAs that regulate HOOK3 (see all 170):
    hsa-miR-411* hsa-miR-520f hsa-miR-3938 hsa-miR-106a hsa-miR-3074-3p hsa-miR-4275 hsa-miR-208b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidHOOK3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOOK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/12 Interacting proteins for HOOK3 (Q86VS81, 3 ENSP000003056994) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MSR1P217571, 3, ENSP000002621014EBI-1777078,EBI-1776976 I2D: score=2 STRING: ENSP00000262101
    AKTIPQ9H8T03, ENSP000003002454I2D: score=1 STRING: ENSP00000300245
    VPS16Q9H2693, ENSP000003698104I2D: score=1 STRING: ENSP00000369810
    VPS41P497543, ENSP000003094574I2D: score=1 STRING: ENSP00000309457
    HOOK1Q9UJC33, ENSP000003602524I2D: score=1 STRING: ENSP00000360252
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0007032endosome organization IMP18799622
    GO:0007040lysosome organization IMP18799622
    GO:0008333endosome to lysosome transport IMP18799622
    GO:0015031protein transport IEA--

    HOOK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOOK3

    Search CenterWatch for drugs/clinical trials and news about HOOK3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOOK3 gene: 
    NM_032410.3  

    Unigene Cluster for HOOK3:

    Hook homolog 3 (Drosophila)
    Hs.162852  [show with all ESTs]
    Unigene Representative Sequence: NM_032410
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000307602(uc003xpr.3) ENST00000527306(uc010lxq.1) ENST00000526882
    ENST00000533539 ENST00000524839 ENST00000533338
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/170 QIAGEN miScript miRNA Assays for microRNAs that regulate HOOK3 (see all 170):
    hsa-miR-411* hsa-miR-520f hsa-miR-3938 hsa-miR-106a hsa-miR-3074-3p hsa-miR-4275 hsa-miR-208b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidHOOK3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK055620.1 AK090540.1 AK309224.1 BC012030.1 BC013679.1 BC023658.2 BC048304.1 BC056146.1 

    17 DOTS entries:

    DT.40253185  DT.95369173  DT.91713073  DT.97774391  DT.40283653  DT.65286464  DT.452755  DT.91742742 
    DT.91689735  DT.91806754  DT.95369171  DT.100740074  DT.95207446  DT.120641586  DT.40188573  DT.95248810 
    DT.120641604 

    24/146 AceView cDNA sequences (see all 146):

    BM716064 BU076240 H00999 BQ271018 BC056146 AA705942 AI637995 BM677206 
    BQ575646 AI082220 AL712787 BU165761 BM055395 BC023658 AK090540 BM968722 
    AW182857 AX746500 BU784756 NM_032410 BX479694 AA903828 BE676716 AA746112 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOOK3 expression in normal human tissues (normalized intensities)      HOOK3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCCAATAA
    HOOK3 Expression
    About this image


    HOOK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 5 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
             sperm   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See HOOK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOOK3

    SOURCE GeneReport for Unigene cluster: Hs.162852
        SABiosciences Custom PCR Arrays for HOOK3
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOOK3 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hook31 , 5 hook homolog 3 (Drosophila)1, 5 90.44(n)1
    97.77(a)1
      8 (14.29 cM)5
    3201911  NM_207659.31  NP_997542.11 
     260214215 
    chicken
    (Gallus gallus)
    Aves HOOK31 hook homolog 3 (Drosophila) 83.36(n)
    94.83(a)
      427297  XM_003643039.1  XP_003643087.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOOK36
    hook homolog 3 (Drosophila)
    95(a)
    1 ↔ 1
    GL343339.1(946179-1018982)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ386025.12   -- 78.62(n)    BQ386025.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.54402 Transcribed sequence with moderate similarity to protein more 72.57(n)    57053533 
    fruit fly
    (Drosophila melanogaster)
    Insecta hk1 , 3 endocytosis3
    hook1
    34(a)3
    46.48(n)1
    36.54(a)1
      2 37B103
    351691  NM_057225.31  NP_476573.11 
    worm
    (Caenorhabditis elegans)
    Secernentea zyg-126
    Zygote defective protein 12
    13(a)
    1 → many
    II(4949900-4953488)


    ENSEMBL Gene Tree for HOOK3 (if available)
    TreeFam Gene Tree for HOOK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOOK3 gene
    HOOK22  HOOK12  CCDC88C2  CCDC88A2  CCDC88B2  
    2 SIMAP similar genes for HOOK3 using alignment to 4 protein entries:     HOOK3_HUMAN (see all proteins):
    HOOK1    HOOK2

    HOOK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2197 SNPs in HOOK3 are shown (see all 2197)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357104
    A breast cancer sample4--see VAR_0357102 Q R mis40--------
    rs1863413031,2
    --42754022(+) AGAACA/GCTTAC 1 -- int10--------
    rs1892263451,2
    --42754061(+) ACCACA/GAAACG 1 -- int10--------
    rs7081891,2
    C,H--42754081(-) CAACAC/ATTTAT 1 -- int111Minor allele frequency- A:0.00NA WA CSA 137
    rs785910001,2
    C,F--42754147(+) TATGGG/ACACTC 1 -- int12Minor allele frequency- A:0.10CSA WA 120
    rs1463852141,2
    C--42754207(+) AAGTC-/TTAAG 
            
    TTAAA
    1 -- int10--------
    rs1485228931,2
    --42754333(+) TAGAAA/GTTTGA 1 -- int10--------
    rs1809533941,2
    --42754427(+) CAGCTA/GTAGAG 1 -- int10--------
    rs736353301,2
    C,F--42754609(+) TAGAGT/ATTAAA 1 -- int12Minor allele frequency- A:0.06WA 120
    rs736353311,2
    C--42754708(+) ATCACC/TCCTCC 1 -- int13Minor allele frequency- T:0.06WA NA 240

    HapMap Linkage Disequilibrium report for HOOK3 (42752033 - 42885682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HOOK3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1916461CNV Deletion18987734
    nsv890846CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607825    OMIM disorders: --

    3 diseases for HOOK3:    About MalaCards
    papillary thyroid carcinoma    thyroiditis    neuronitis


    HOOK3 for disorders           About GeneDecksing


    Export disorders for HOOK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOOK3 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with HOOK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. (PubMed id 17237231)1, 2, 9 Sano H.... Kuroki Y. (2007)
    2. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PubMed id 11238449)1, 2, 9 Walenta J.H.... Kraemer H. (2001)
    3. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PubMed id 18799622)1, 2 Xu L....Harper J.W. (2008)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PubMed id 9927460)1, 3 Kraemer H. and Phistry M. (1999)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84376 HGNC: 23576 AceView: HOOK3 Ensembl:ENSG00000168172 euGenes: HUgn84376
    ECgene: HOOK3 H-InvDB: HOOK3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOOK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOOK3 gene:
    Search GeneIP for patents involving HOOK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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