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Aliases for HOOK3 Gene

Aliases for HOOK3 Gene

  • Hook Microtubule Tethering Protein 3 2 3 5
  • H-Hook3 3 4
  • HHK3 3 4
  • Hook Homolog 3 (Drosophila) 2
  • Protein Hook Homolog 3 3
  • Hook Homolog 3 3
  • HK3 3

External Ids for HOOK3 Gene

Previous GeneCards Identifiers for HOOK3 Gene

  • GC12M9A0079
  • GC08P042821
  • GC08P042492
  • GC08P042769
  • GC08P042871
  • GC08P041277

Summaries for HOOK3 Gene

Entrez Gene Summary for HOOK3 Gene

  • Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

GeneCards Summary for HOOK3 Gene

HOOK3 (Hook Microtubule Tethering Protein 3) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and microtubule binding. An important paralog of this gene is HOOK1.

UniProtKB/Swiss-Prot for HOOK3 Gene

  • Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.

Gene Wiki entry for HOOK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOOK3 Gene

Genomics for HOOK3 Gene

Regulatory Elements for HOOK3 Gene

Enhancers for HOOK3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F042841 0.2 ENCODE 18.9 -54.0 -54010 3.5 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000254165 HOOK3 IKBKB MIR4469 RNF170 KAT6A FNTA THAP1 CHRNA6
GH08F043054 0.5 ENCODE 17.3 +159.6 159646 4.0 PKNOX1 ARNT MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 HOOK3 IKBKB ENSG00000254673 ENSG00000254198 HGSNAT MIR4469 RNF170 POMK THAP1 FNTA
GH08F042028 0.5 ENCODE 12.9 -868.0 -868007 0.7 ZNF791 ZNF133 IRF1 SETDB1 KAT6A ENSG00000254165 HOOK3 IKBKB ENSG00000238966 GC08P041904
GH08F042171 0.7 Ensembl ENCODE 12.9 -725.0 -725034 1.1 SIN3A ARID4B NFXL1 ZNF2 RAD21 ZNF121 SCRT2 ZNF391 ZNF263 ZNF362 IKBKB POLB ENSG00000254165 PLAT HOOK3 LOC101929897 VDAC3 DKK4 KAT6A PIR61234
GH08F043059 0.2 Ensembl 11.8 +162.6 162611 0.2 ATF3 CEBPG SP7 ENSG00000254673 HOOK3 ENSG00000254198 HGSNAT MIR4469 RNF170 POMK THAP1 GC08P043074 FNTA
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HOOK3 on UCSC Golden Path with GeneCards custom track

Promoters for HOOK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001390986 210 3401 HDGF ARID4B SIN3A DMAP1 ZNF48 GLIS2 ZNF143 ZNF207 KLF7 KLF13

Genomic Location for HOOK3 Gene

Chromosome:
8
Start:
42,896,890 bp from pter
End:
43,030,539 bp from pter
Size:
133,650 bases
Orientation:
Plus strand

Genomic View for HOOK3 Gene

Genes around HOOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOOK3 Gene

Proteins for HOOK3 Gene

  • Protein details for HOOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VS8-HOOK3_HUMAN
    Recommended name:
    Protein Hook homolog 3
    Protein Accession:
    Q86VS8
    Secondary Accessions:
    • D3DSY8
    • Q8NBH0
    • Q9BY13

    Protein attributes for HOOK3 Gene

    Size:
    718 amino acids
    Molecular mass:
    83126 Da
    Quaternary structure:
    • Interacts with Salmonella typhimurium spiC (By similarity). Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK2. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect. Interacts with MSR1, and this association is stimulated by ligand binding to MSR1. Interacts with microtubules.
    SequenceCaution:
    • Sequence=AAH48304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOOK3 Gene

neXtProt entry for HOOK3 Gene

Post-translational modifications for HOOK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOOK3 Gene

Antibody Products

  • Abcam antibodies for HOOK3
  • Santa Cruz Biotechnology (SCBT) Antibodies for HOOK3

No data available for DME Specific Peptides for HOOK3 Gene

Domains & Families for HOOK3 Gene

Protein Domains for HOOK3 Gene

Suggested Antigen Peptide Sequences for HOOK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VS8

UniProtKB/Swiss-Prot:

HOOK3_HUMAN :
  • Belongs to the hook family.
Family:
  • Belongs to the hook family.
genes like me logo Genes that share domains with HOOK3: view

No data available for Gene Families for HOOK3 Gene

Function for HOOK3 Gene

Molecular function for HOOK3 Gene

UniProtKB/Swiss-Prot Function:
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.

Gene Ontology (GO) - Molecular Function for HOOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17237231
GO:0008017 microtubule binding IDA 11238449
GO:0042802 identical protein binding IPI 18799622
GO:0051959 dynein light intermediate chain binding IBA --
genes like me logo Genes that share ontologies with HOOK3: view
genes like me logo Genes that share phenotypes with HOOK3: view

Animal Models for HOOK3 Gene

MGI Knock Outs for HOOK3:

Animal Model Products

miRNA for HOOK3 Gene

miRTarBase miRNAs that target HOOK3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOOK3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOOK3 Gene

Localization for HOOK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOOK3 Gene

Cytoplasm, cytoskeleton. Golgi apparatus. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOOK3 Gene COMPARTMENTS Subcellular localization image for HOOK3 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
cytosol 3
nucleus 3
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HOOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material ISS --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005801 cis-Golgi network IDA 11238449
GO:0005813 centrosome IEA,ISS --
genes like me logo Genes that share ontologies with HOOK3: view

Pathways & Interactions for HOOK3 Gene

SuperPathways for HOOK3 Gene

No Data Available

SIGNOR curated interactions for HOOK3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HOOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0008333 endosome to lysosome transport IMP 18799622
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with HOOK3: view

No data available for Pathways by source for HOOK3 Gene

Transcripts for HOOK3 Gene

Unigene Clusters for HOOK3 Gene

Hook homolog 3 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOOK3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOOK3 Gene

No ASD Table

Relevant External Links for HOOK3 Gene

GeneLoc Exon Structure for
HOOK3
ECgene alternative splicing isoforms for
HOOK3

Expression for HOOK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOOK3 Gene

Protein differential expression in normal tissues from HIPED for HOOK3 Gene

This gene is overexpressed in Bone (41.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOOK3 Gene



Protein tissue co-expression partners for HOOK3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HOOK3 Gene:

HOOK3

SOURCE GeneReport for Unigene cluster for HOOK3 Gene:

Hs.162852
genes like me logo Genes that share expression patterns with HOOK3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HOOK3 Gene

Orthologs for HOOK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOOK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOOK3 34 35
  • 99.86 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 97 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HOOK3 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOOK3 34 35
  • 93.41 (n)
mouse
(Mus musculus)
Mammalia Hook3 34 16 35
  • 90.44 (n)
rat
(Rattus norvegicus)
Mammalia Hook3 34
  • 90.25 (n)
cow
(Bos Taurus)
Mammalia HOOK3 34 35
  • 90.06 (n)
chicken
(Gallus gallus)
Aves HOOK3 34 35
  • 83.64 (n)
lizard
(Anolis carolinensis)
Reptilia HOOK3 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hook3 34
  • 77.78 (n)
zebrafish
(Danio rerio)
Actinopterygii HOOK3 35
  • 73 (a)
OneToOne
Dr.5440 34
fruit fly
(Drosophila melanogaster)
Insecta hk 36 34 35
  • 46.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta HOOK_ANOGA 34
  • 46.34 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4526 34
Species where no ortholog for HOOK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOOK3 Gene

ENSEMBL:
Gene Tree for HOOK3 (if available)
TreeFam:
Gene Tree for HOOK3 (if available)

Paralogs for HOOK3 Gene

Paralogs for HOOK3 Gene

(2) SIMAP similar genes for HOOK3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HOOK3: view

Variants for HOOK3 Gene

Sequence variations from dbSNP and Humsavar for HOOK3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_035710 A breast cancer sample
rs10099800 -- 42,990,814(+) agaag(C/G)ttttt intron-variant
rs10106661 -- 42,998,571(+) GAACC(A/G)AAGAA intron-variant
rs10453137 -- 42,956,660(+) gctca(C/T)tgcaa intron-variant
rs1052654 -- 43,030,212(+) TGTTA(A/C)AGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HOOK3 Gene

Variant ID Type Subtype PubMed ID
esv1916461 CNV deletion 18987734
esv3891387 CNV gain 25118596
nsv1032781 CNV gain 25217958
nsv480663 CNV novel sequence insertion 20440878

Variation tolerance for HOOK3 Gene

Residual Variation Intolerance Score: 6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOOK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOOK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOOK3 Gene

Disorders for HOOK3 Gene

Relevant External Links for HOOK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOOK3

No disorders were found for HOOK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOOK3 Gene

Publications for HOOK3 Gene

  1. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. (PMID: 17237231) Sano H. … Kuroki Y. (J. Biol. Chem. 2007) 3 4 22 64
  2. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PMID: 11238449) Walenta J.H. … Kraemer H. (J. Cell Biol. 2001) 3 4 22 64
  3. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PMID: 18799622) Xu L. … Harper J.W. (Mol. Biol. Cell 2008) 3 4 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for HOOK3 Gene

Sources for HOOK3 Gene

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