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Aliases for HOOK3 Gene

Aliases for HOOK3 Gene

  • Hook Microtubule-Tethering Protein 3 2 3 5
  • H-Hook3 3 4
  • HHK3 3 4
  • Hook Homolog 3 (Drosophila) 2
  • Hook Homolog 3 3
  • HK3 3

External Ids for HOOK3 Gene

Previous GeneCards Identifiers for HOOK3 Gene

  • GC12M9A0079
  • GC08P042821
  • GC08P042492
  • GC08P042769
  • GC08P042871
  • GC08P041277

Summaries for HOOK3 Gene

Entrez Gene Summary for HOOK3 Gene

  • Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

GeneCards Summary for HOOK3 Gene

HOOK3 (Hook Microtubule-Tethering Protein 3) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include identical protein binding and microtubule binding. An important paralog of this gene is CCDC88A.

UniProtKB/Swiss-Prot for HOOK3 Gene

  • Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.

Gene Wiki entry for HOOK3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOOK3 Gene

Genomics for HOOK3 Gene

Regulatory Elements for HOOK3 Gene

Promoters for HOOK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HOOK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOOK3 Gene

Chromosome:
8
Start:
42,896,890 bp from pter
End:
43,030,539 bp from pter
Size:
133,650 bases
Orientation:
Plus strand

Genomic View for HOOK3 Gene

Genes around HOOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOOK3 Gene

Proteins for HOOK3 Gene

  • Protein details for HOOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VS8-HOOK3_HUMAN
    Recommended name:
    Protein Hook homolog 3
    Protein Accession:
    Q86VS8
    Secondary Accessions:
    • D3DSY8
    • Q8NBH0
    • Q9BY13

    Protein attributes for HOOK3 Gene

    Size:
    718 amino acids
    Molecular mass:
    83126 Da
    Quaternary structure:
    • Interacts with Salmonella typhimurium spiC (By similarity). Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK2. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect. Interacts with MSR1, and this association is stimulated by ligand binding to MSR1. Interacts with microtubules.
    SequenceCaution:
    • Sequence=AAH48304.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for HOOK3 Gene

Proteomics data for HOOK3 Gene at MOPED

Post-translational modifications for HOOK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOOK3 Gene

No data available for DME Specific Peptides for HOOK3 Gene

Domains & Families for HOOK3 Gene

Protein Domains for HOOK3 Gene

Suggested Antigen Peptide Sequences for HOOK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VS8

UniProtKB/Swiss-Prot:

HOOK3_HUMAN :
  • Belongs to the hook family.
Family:
  • Belongs to the hook family.
genes like me logo Genes that share domains with HOOK3: view

No data available for Gene Families for HOOK3 Gene

Function for HOOK3 Gene

Molecular function for HOOK3 Gene

UniProtKB/Swiss-Prot Function:
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.
genes like me logo Genes that share phenotypes with HOOK3: view

Animal Model Products

miRNA for HOOK3 Gene

miRTarBase miRNAs that target HOOK3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HOOK3 Gene

Localization for HOOK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOOK3 Gene

Cytoplasm, cytoskeleton. Golgi apparatus. Note=Enriched at the cis-face of the Golgi complex. Localizes to microtubule asters in prophase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOOK3 Gene COMPARTMENTS Subcellular localization image for HOOK3 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
cytosol 3
nucleus 3
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HOOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005801 cis-Golgi network IDA 11238449
GO:0005813 centrosome IEA,ISS --
GO:0005874 microtubule IEA --
GO:0034451 centriolar satellite IEA --
GO:0070695 FHF complex IDA 18799622
genes like me logo Genes that share ontologies with HOOK3: view

Pathways & Interactions for HOOK3 Gene

genes like me logo Genes that share pathways with HOOK3: view

SIGNOR curated interactions for HOOK3 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for HOOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0008333 endosome to lysosome transport IMP 18799622
GO:0031122 cytoplasmic microtubule organization IMP 11238449
GO:0034454 microtubule anchoring at centrosome IEA,ISS --
genes like me logo Genes that share ontologies with HOOK3: view

Drugs & Compounds for HOOK3 Gene

No Compound Related Data Available

Transcripts for HOOK3 Gene

Unigene Clusters for HOOK3 Gene

Hook homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOOK3 Gene

No ASD Table

Relevant External Links for HOOK3 Gene

GeneLoc Exon Structure for
HOOK3
ECgene alternative splicing isoforms for
HOOK3

Expression for HOOK3 Gene

mRNA expression in normal human tissues for HOOK3 Gene

Protein differential expression in normal tissues from HIPED for HOOK3 Gene

This gene is overexpressed in Bone (41.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOOK3 Gene



SOURCE GeneReport for Unigene cluster for HOOK3 Gene Hs.162852

genes like me logo Genes that share expression patterns with HOOK3: view

Protein tissue co-expression partners for HOOK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HOOK3 Gene

Orthologs for HOOK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOOK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOOK3 36
  • 100 (a)
OneToOne
HOOK3 35
  • 99.86 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia HOOK3 36
  • 98 (a)
OneToOne
HOOK3 35
  • 90.06 (n)
  • 98.33 (a)
dog
(Canis familiaris)
Mammalia HOOK3 35
  • 93.41 (n)
  • 98.89 (a)
HOOK3 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hook3 36
  • 98 (a)
OneToOne
Hook3 16
Hook3 35
  • 90.44 (n)
  • 97.77 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 97 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia HOOK3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hook3 35
  • 90.25 (n)
  • 97.91 (a)
chicken
(Gallus gallus)
Aves HOOK3 35
  • 83.64 (n)
  • 95.26 (a)
HOOK3 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOOK3 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hook3 35
  • 77.78 (n)
  • 89.96 (a)
zebrafish
(Danio rerio)
Actinopterygii HOOK3 36
  • 73 (a)
OneToOne
Dr.5440 35
African malaria mosquito
(Anopheles gambiae)
Insecta HOOK_ANOGA 35
  • 46.34 (n)
  • 37.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta hk 37
  • 34 (a)
hk 35
  • 46.94 (n)
  • 37.18 (a)
hk 36
  • 35 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4526 35
Species with no ortholog for HOOK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOOK3 Gene

ENSEMBL:
Gene Tree for HOOK3 (if available)
TreeFam:
Gene Tree for HOOK3 (if available)

Paralogs for HOOK3 Gene

Paralogs for HOOK3 Gene

(2) SIMAP similar genes for HOOK3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HOOK3: view

Variants for HOOK3 Gene

Sequence variations from dbSNP and Humsavar for HOOK3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_035710 A breast cancer sample
rs34131505 - 43,013,393(-) TATTG(G/T)ACCAG reference, missense
rs773070 -- 42,902,717(-) AGATT(C/G)GGGAA intron-variant
rs773071 -- 42,908,351(-) tttgg(C/T)tattt intron-variant
rs773072 -- 42,907,811(-) gcctc(A/G)ttgct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOOK3 Gene

Variant ID Type Subtype PubMed ID
nsv890846 CNV Gain 21882294
esv1916461 CNV Deletion 18987734

Variation tolerance for HOOK3 Gene

Residual Variation Intolerance Score: 6.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOOK3 Gene

HapMap Linkage Disequilibrium report
HOOK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOOK3 Gene

Disorders for HOOK3 Gene

Relevant External Links for HOOK3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOOK3

No disorders were found for HOOK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOOK3 Gene

Publications for HOOK3 Gene

  1. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. (PMID: 17237231) Sano H. … Kuroki Y. (J. Biol. Chem. 2007) 3 4 23 67
  2. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PMID: 11238449) Walenta J.H. … Kraemer H. (J. Cell Biol. 2001) 3 23
  3. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PMID: 9927460) Kraemer H. … Phistry M. (Genetics 1999) 2 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for HOOK3 Gene

Sources for HOOK3 Gene

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