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Aliases for HOOK2 Gene

Aliases for HOOK2 Gene

  • Hook Microtubule-Tethering Protein 2 2 3
  • H-Hook2 3 4
  • HHK2 3 4
  • HK2 3 6
  • Hook Homolog 2 (Drosophila) 2
  • Protein Hook Homolog 2 3
  • Hook Homolog 2 3

External Ids for HOOK2 Gene

Summaries for HOOK2 Gene

Entrez Gene Summary for HOOK2 Gene

  • Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

GeneCards Summary for HOOK2 Gene

HOOK2 (Hook Microtubule-Tethering Protein 2) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include identical protein binding. An important paralog of this gene is CCDC88A.

UniProtKB/Swiss-Prot for HOOK2 Gene

  • Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.

Gene Wiki entry for HOOK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOOK2 Gene

Genomics for HOOK2 Gene

Genomic Location for HOOK2 Gene

Start:
12,763,003 bp from pter
End:
12,872,740 bp from pter
Size:
109,738 bases
Orientation:
Minus strand

Genomic View for HOOK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOOK2 Gene

Regulatory Elements for HOOK2 Gene

Proteins for HOOK2 Gene

  • Protein details for HOOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ED9-HOOK2_HUMAN
    Recommended name:
    Protein Hook homolog 2
    Protein Accession:
    Q96ED9
    Secondary Accessions:
    • O60562

    Protein attributes for HOOK2 Gene

    Size:
    719 amino acids
    Molecular mass:
    83207 Da
    Quaternary structure:
    • Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect. Interacts with CNTRL. Interacts with microtubules. Interacts with ZC3H14.

    Alternative splice isoforms for HOOK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOOK2 Gene

Proteomics data for HOOK2 Gene at MOPED

Post-translational modifications for HOOK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HOOK2 Gene

Domains for HOOK2 Gene

Protein Domains for HOOK2 Gene

Suggested Antigen Peptide Sequences for HOOK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ED9

UniProtKB/Swiss-Prot:

HOOK2_HUMAN
Family:
  • Belongs to the hook family.:
    • Q96ED9
genes like me logo Genes that share domains with HOOK2: view

No data available for Gene Families for HOOK2 Gene

Function for HOOK2 Gene

Molecular function for HOOK2 Gene

UniProtKB/Swiss-Prot Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.

Gene Ontology (GO) - Molecular Function for HOOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 18799622
genes like me logo Genes that share ontologies with HOOK2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HOOK2 Gene

Localization for HOOK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOOK2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOOK2 Gene COMPARTMENTS Subcellular localization image for HOOK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HOOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005813 centrosome IDA 17140400
GO:0005874 microtubule IEA --
GO:0030897 colocalizes_with HOPS complex IDA 18799622
GO:0070695 FHF complex IDA 18799622
genes like me logo Genes that share ontologies with HOOK2: view

Pathways for HOOK2 Gene

genes like me logo Genes that share pathways with HOOK2: view

Gene Ontology (GO) - Biological Process for HOOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis TAS 9927460
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0008333 endosome to lysosome transport IMP 18799622
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with HOOK2: view

Transcripts for HOOK2 Gene

Unigene Clusters for HOOK2 Gene

Hook homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOOK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - - -
SP2:
SP3: - - - - -
SP4: -
SP5:
SP6: - -
SP7: -
SP8:
SP9:
SP10:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HOOK2 Gene

GeneLoc Exon Structure for
HOOK2
ECgene alternative splicing isoforms for
HOOK2

Expression for HOOK2 Gene

mRNA expression in normal human tissues for HOOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOOK2 Gene

This gene is overexpressed in Pituitary (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOOK2 Gene

SOURCE GeneReport for Unigene cluster for HOOK2 Gene Hs.30792

genes like me logo Genes that share expressions with HOOK2: view

No data available for mRNA Expression by UniProt/SwissProt for HOOK2 Gene

Orthologs for HOOK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOOK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOOK2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOOK2 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOOK2 35
  • 89.09 (n)
  • 92.76 (a)
HOOK2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hook2 35
  • 83.52 (n)
  • 86.31 (a)
Hook2 16
Hook2 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOOK2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOOK2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hook2 35
  • 83.71 (n)
  • 85.75 (a)
lizard
(Anolis carolinensis)
Reptilia HOOK2 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1897 35
tropical clawed frog
(Silurana tropicalis)
Amphibia hook2 35
  • 63.89 (n)
  • 60.08 (a)
zebrafish
(Danio rerio)
Actinopterygii hook2 35
  • 64.55 (n)
  • 58.05 (a)
hook2 36
  • 55 (a)
OneToOne
zgc66419 35
fruit fly
(Drosophila melanogaster)
Insecta hk 36
  • 31 (a)
OneToMany
Species with no ortholog for HOOK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOOK2 Gene

ENSEMBL:
Gene Tree for HOOK2 (if available)
TreeFam:
Gene Tree for HOOK2 (if available)

Paralogs for HOOK2 Gene

Paralogs for HOOK2 Gene

genes like me logo Genes that share paralogs with HOOK2: view

Variants for HOOK2 Gene

Sequence variations from dbSNP and Humsavar for HOOK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs897804 - 12,766,150(-) CGCCA(C/G)CTGGA reference, missense
rs1129182 -- 12,771,068(-) GGCTG(A/G)AGAGT missense, reference
rs1205169 -- 12,765,464(+) GAAAG(A/C)AGGCC intron-variant
rs2290285 -- 12,770,713(+) GGGGG(A/G)GCAGT intron-variant
rs2305376 - 12,775,422(+) AGACC(C/T)GCATA missense, reference, intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HOOK2 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911077 CNV Loss 21882294
nsv911079 CNV Loss 21882294
dgv3734n71 CNV Loss 21882294
esv2667754 CNV Deletion 23128226

Relevant External Links for HOOK2 Gene

HapMap Linkage Disequilibrium report
HOOK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOOK2 Gene

Disorders for HOOK2 Gene

No disorders were found for HOOK2 Gene.

No data available for UniProtKB/Swiss-Prot for HOOK2 Gene

Publications for HOOK2 Gene

  1. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PMID: 9927460) Kraemer H. … Phistry M. (Genetics 1999) 2 3 4
  2. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PMID: 11238449) Walenta J.H. … Kraemer H. (J. Cell Biol. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. (PMID: 17140400) Szebenyi G. … Kraemer H. (Traffic 2007) 3 4
  5. Hook2 contributes to aggresome formation. (PMID: 17540036) Szebenyi G. … Kraemer H. (BMC Cell Biol. 2007) 3 4

Products for HOOK2 Gene

Sources for HOOK2 Gene

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