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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HOOK2 Gene

protein-coding GIFtS: 50
GCID: GC19M012873

hook homolog 2 (Drosophila)

Search for HOOK2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Hook Homolog 2 (Drosophila)¹ ²
HK2¹ ² ⁵
H-Hook2¹
HHK2¹
Protein Hook Homolog 2²

External Ids:	HGNC: 19885¹	Entrez Gene: 29911²	Ensembl: ENSG00000095066⁷	OMIM: 607824⁵	UniProtKB: Q96ED9³

Export aliases for HOOK2 gene to outside databases

Previous GC identifers: GC19M013005 GC19M013096 GC19M012719 GC19M012734 GC19M012446

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOOK2:

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to

microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein

is a component of the endocytic compartment.(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: HOOK2_HUMAN, Q96ED9

Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle

trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the

establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes,

which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones

summary for HOOK2:

Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose

into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial

oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which

has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer

mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as

skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation

and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose

metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for HOOK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011295.11

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HOOK2 gene promoter:
AREB6 SRF p53 Egr-1 SRF (504 AA) NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOOK2 promoter sequence

Search SABiosciences Chromatin IP Primers for HOOK2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOOK2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2

HOOK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOOK2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M012873: view genomic region (about GC identifiers)

Start:	12,873,817 bp from pter	End:	12,983,554 bp from pter
Size:	109,738 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HOOK2_HUMAN, Q96ED9 (See protein sequence)

Recommended Name: Protein Hook homolog 2

Size: 719 amino acids; 83207 Da

Subunit: Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and

one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS,

HOOK1 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex)

including VPS16 and VPS41; these interactions may be indirect. Interacts with CEP110. Interacts with microtubules.

Interacts with ZC3H14

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with

aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci

which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex,

multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules

Secondary accessions: O60562

Alternative splicing: 2 isoforms: Q96ED9-1 Q96ED9-2

Explore the universe of human proteins at neXtProt for HOOK2: NX_Q96ED9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96ED9

HOOK2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001093646.1 NP_037444.2

ENSEMBL proteins:

ENSP00000380785 ENSP00000264827 ENSP00000465091 ENSP00000467097 ENSP00000465023

ENSP00000466616 ENSP00000465427 ENSP00000466497 ENSP00000467739 ENSP00000465042

Human Recombinant Protein Products for HOOK2:

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	Novus Biologicals HOOK2 Proteins Novus Biologicals HOOK2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for HOOK2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005813	centrosome	IDA	17140400
GO:0005874	microtubule	IEA	--
GO:0030897	colocalizes with HOPS complex	IDA	18799622
GO:0070695	FHF complex	IDA	18799622

HOOK2 for ontologies About GeneDecksing

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Assay Products for HOOK2:

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	Uscn ELISAs and CLIAs for HOOK2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HOOK2 for domains About GeneDecksing

1 InterPro domain/family:

IPR008636 HOOK

Graphical View of Domain Structure for InterPro Entry Q96ED9

ProtoNet protein and cluster: Q96ED9

2 Blocks protein families:

IPB001715 Calponin-like actin-binding

IPB008636 HOOK

UniProtKB/Swiss-Prot: HOOK2_HUMAN, Q96ED9

Similarity: Belongs to the hook family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HOOK2_HUMAN, Q96ED9

Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle

trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the

establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes,

which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16189514
GO:0008017	microtubule binding	IEA	--
GO:0042802	identical protein binding	IPI	18799622

HOOK2 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOOK2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HOOK2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOOK2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate HOOK2:
		hsa-miR-3671 hsa-miR-3163 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
		SwitchGear 3'UTR luciferase reporter plasmid: HOOK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOOK2 (see all 4) OriGene shRNA RFP: HOOK2 OriGene siRNA: HOOK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOOK2
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOOK2 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOOK2 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOOK2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for HOOK2

STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

5/36 Interacting proteins for HOOK2 (Q96ED9^{1, 2, 3} ENSP00000380785⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABLIM1	O14639²^,³, ENSP00000338190⁴	MINT-68094 I2D: score=5 STRING: ENSP00000338190
AKTIP	Q9H8T0²^,³, ENSP00000300245⁴	MINT-67661 I2D: score=5 STRING: ENSP00000300245
APEX2	Q9UBZ4²^,³, ENSP00000364126⁴	MINT-67126 I2D: score=5 STRING: ENSP00000364126
EPS8	Q12929²^,³, ENSP00000281172⁴	MINT-68090 I2D: score=5 STRING: ENSP00000281172
FAM107A	O95990²^,³, ENSP00000354270⁴	MINT-67732 I2D: score=5 STRING: ENSP00000354270

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	IEA	--
GO:0006897	endocytosis	TAS	9927460
GO:0007032	endosome organization	IMP	18799622
GO:0007040	lysosome organization	IMP	18799622
GO:0008333	endosome to lysosome transport	IMP	18799622

HOOK2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for HOOK2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Lonidamine	Mitochondrial hexokinase inhibitor	[50264-69-2]

Search CenterWatch for drugs/clinical trials and news about HOOK2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HOOK2 gene (2 alternative transcripts):

NM_001100176.1 NM_013312.2

Unigene Cluster for HOOK2:

Hook homolog 2 (Drosophila)

Hs.30792 [show with all ESTs]

Unigene Representative Sequence: NM_013312

18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):

ENST00000397668(uc002muy.2) ENST00000264827(uc002muz.2) ENST00000589915

ENST00000586710 ENST00000586188 ENST00000592259 ENST00000589965 ENST00000591839

ENST00000589398 ENST00000589400 ENST00000592079 ENST00000586284 ENST00000590839

ENST00000586719 ENST00000588052 ENST00000587964 ENST00000587178 ENST00000592808

miRNA Products:		OriGene 3'-UTR Clone (see all 2): HOOK2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOOK2
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate HOOK2:
		hsa-miR-3671 hsa-miR-3163 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-23c
		SwitchGear 3'UTR luciferase reporter plasmid: HOOK2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOOK2 (see all 4) OriGene shRNA RFP: HOOK2 OriGene siRNA: HOOK2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOOK2
		Sirion Biotech Custom design and validation of potent shRNA sequences against HOOK2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOOK2

Additional cDNA sequence:

AF044924.1 BC012443.1

18 DOTS entries:

DT.455292 DT.91763987 DT.100023232 DT.100765494 DT.95161455 DT.121433791 DT.100659045 DT.100754074

DT.100746086 DT.101975896 DT.75190335 DT.95161456 DT.121433801 DT.40111094 DT.91763985 DT.97767763

DT.100706696 DT.99931993

24/157 AceView cDNA sequences (see all 157):

AI648501 AI955361 BG108456 AA479096 BQ774589 BE165028 AI499241 CA843683

BC012443 AI432543 BI819433 BM982435 CR590832 CK429789 CK825820 BI829135

BI038036 AA553952 CA448702 BQ447998 BQ269738 AL119893 CK825819 BF968257

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HOOK2 (see all 10) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d	·	4e	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	^	17a	·
SP1:													-		-		-		-		-																										-
SP2:
SP3:													-		-		-		-		-
SP4:																																															-
SP5:

ExUns:	17b	^	18	^	19a	·	19b	^	20a	·	20b	^	21	^	22	^	23
SP1:	-				-
SP2:	-				-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for HOOK2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HOOK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTGCCTCA

About this image

HOOK2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Hindgut

Hindgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Hindgut

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HOOK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HOOK2

SOURCE GeneReport for Unigene cluster: Hs.30792

SABiosciences Custom PCR Arrays for HOOK2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOOK2

In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HOOK2 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Hook2^{1 , 5}	hook homolog 2 (Drosophila)^{1, 5}	83.5(n)¹ 86.29(a)¹		8 (41.44 cM)⁵ 170833¹ NM_001167991.1¹ NP_001161463.1¹ 84990595⁵
lizard (Anolis carolinensis)	Reptilia	HOOK2⁶	--	63(a)	1 ↔ 1	GL343286.1(893159-914513)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1897²	Xenopus laevis cDNA clone IMAGE4174467, partial cds	74.61(n)		BC060438.1
zebrafish (Danio rerio)	Actinopterygii	zgc66419²	similar to hook homolog 2 (Drosophila)	72.18(n)		394086 BC055648.1
fruit fly (Drosophila melanogaster)	Insecta	hk⁶	hook	31(a)	1 → many	2L(19030838-19033495)
worm (Caenorhabditis elegans)	Secernentea	zyg-12⁶	Zygote defective protein 12	17(a)	possible ortholog	II(4949894-4953482)

ENSEMBL Gene Tree for HOOK2 (if available)
TreeFam Gene Tree for HOOK2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HOOK2 gene

HOOK1² CCDC88A² CCDC88C² HOOK3² CCDC88B²

9 SIMAP similar genes for HOOK2 using alignment to 9 protein entries: HOOK2_HUMAN (see all proteins):

APOPT1 ZNF527 FAM175A CRCP SKA2 TCF4

HOOK3 HOOK1 C4orf21

HOOK2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139528178^1,2	C	--	12873317(+)	`AAAAA-/GCAAC AACAACCAAAAA`	2	--	ds500¹		0	--	--	--	--
rs187744619^1,2		--	12873499(+)	`GGCATA/GATCTC`	2	--	ds500¹		0	--	--	--	--
rs192425957^1,2		--	12873682(+)	`CCACCC/TGCCTC`	2	--	ds500¹		0	--	--	--	--
rs184397935^1,2		--	12873725(+)	`GCCACC/TGTACC`	2	--	ds500¹		0	--	--	--	--
rs189026985^1,2		--	12873736(+)	`TGGCCA/GCTAAG`	2	--	ds500¹		0	--	--	--	--
rs78869852^1,2	F	--	12873793(+)	`CTCACC/TTTGGT`	2	--	ds500¹		1		NA	120
rs181467353^1,2		--	12873827(+)	`TTGAAC/TGCCTT`	2	--	ut3¹		0	--	--	--	--
rs77655746^1,2		--	12873907(+)	`AAGAAA/TCACAT`	2	--	ut3¹		0	--	--	--	--
rs184013402^1,2		--	12873944(+)	`CCTCCC/TGCCCT`	2	--	ut3¹		0	--	--	--	--
rs141137946^1,2		--	12874021(+)	`TGAAGC/GCCAGT`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HOOK2 (12873817 - 12983554 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for HOOK2
1 CNV: 4400

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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HOOK2 for disorders About MalaCards

HOOK2 for disorders About GeneDecksing

OMIM gene information: 607824 OMIM disorders: --

Export disorders for HOOK2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for HOOK2 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with HOOK2)

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Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PubMed id 9927460)^{1, 2, 3} Kraemer H. and Phistry M. (1999)
An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PubMed id 18799622)^{1, 2} Xu L....Harper J.W. (2008)
Hook2 contributes to aggresome formation. (PubMed id 17540036)^{1, 2} Szebenyi G....Kraemer H. (2007)
Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. (PubMed id 17140400)^{1, 2} Szebenyi G.... Kraemer H. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PubMed id 11238449)^{1, 2} Walenta J.H.... Kraemer H. (2001)
Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)¹ Wong K.A....O'Bryan J.P. (2012)
Hook2 is involved in the morphogenesis of the primary cilium. (PubMed id 21998199)¹ Baron Gaillard C.L....Le Bivic A. (2011)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. (PubMed id 19273536)² Guthrie C.R....Kraemer B.C. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 29911	HGNC: 19885	AceView: HOOK2	Ensembl:ENSG00000095066	euGenes: HUgn29911
ECgene: HOOK2	H-InvDB: HOOK2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HOOK2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HOOK2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HOOK2 gene:
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hook homolog 2 (Drosophila)

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hook homolog 2 (Drosophila)

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