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Aliases for HOOK2 Gene

Aliases for HOOK2 Gene

  • Hook Microtubule-Tethering Protein 2 2 3 5
  • H-Hook2 3 4
  • HHK2 3 4
  • Hook Homolog 2 (Drosophila) 2
  • Hook Homolog 2 3
  • HK2 3

External Ids for HOOK2 Gene

Previous GeneCards Identifiers for HOOK2 Gene

  • GC19M013005
  • GC19M013096
  • GC19M012719
  • GC19M012734
  • GC19M012873
  • GC19M012446
  • GC19M012766
  • GC19M012769

Summaries for HOOK2 Gene

Entrez Gene Summary for HOOK2 Gene

  • Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

GeneCards Summary for HOOK2 Gene

HOOK2 (Hook Microtubule-Tethering Protein 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include identical protein binding. An important paralog of this gene is CCDC88A.

UniProtKB/Swiss-Prot for HOOK2 Gene

  • Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.

Gene Wiki entry for HOOK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOOK2 Gene

Genomics for HOOK2 Gene

Regulatory Elements for HOOK2 Gene

Genomic Location for HOOK2 Gene

Chromosome:
19
Start:
12,763,003 bp from pter
End:
12,872,740 bp from pter
Size:
109,738 bases
Orientation:
Minus strand

Genomic View for HOOK2 Gene

Genes around HOOK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOOK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOOK2 Gene

Proteins for HOOK2 Gene

  • Protein details for HOOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96ED9-HOOK2_HUMAN
    Recommended name:
    Protein Hook homolog 2
    Protein Accession:
    Q96ED9
    Secondary Accessions:
    • O60562

    Protein attributes for HOOK2 Gene

    Size:
    719 amino acids
    Molecular mass:
    83207 Da
    Quaternary structure:
    • Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK1 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16 and VPS41; these interactions may be indirect. Interacts with CNTRL. Interacts with microtubules. Interacts with ZC3H14. Interacts with LRGUK (By similarity).

    Alternative splice isoforms for HOOK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOOK2 Gene

Proteomics data for HOOK2 Gene at MOPED

Post-translational modifications for HOOK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HOOK2 Gene

Domains & Families for HOOK2 Gene

Protein Domains for HOOK2 Gene

Suggested Antigen Peptide Sequences for HOOK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96ED9

UniProtKB/Swiss-Prot:

HOOK2_HUMAN :
  • Belongs to the hook family.
Family:
  • Belongs to the hook family.
genes like me logo Genes that share domains with HOOK2: view

No data available for Gene Families for HOOK2 Gene

Function for HOOK2 Gene

Molecular function for HOOK2 Gene

UniProtKB/Swiss-Prot Function:
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.
genes like me logo Genes that share phenotypes with HOOK2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HOOK2 Gene

Localization for HOOK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOOK2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOOK2 Gene COMPARTMENTS Subcellular localization image for HOOK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HOOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030897 colocalizes_with HOPS complex IDA 18799622
GO:0070695 FHF complex IDA 18799622
genes like me logo Genes that share ontologies with HOOK2: view

Pathways & Interactions for HOOK2 Gene

genes like me logo Genes that share pathways with HOOK2: view

SIGNOR curated interactions for HOOK2 Gene

Activates:

Gene Ontology (GO) - Biological Process for HOOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045022 early endosome to late endosome transport IMP 18799622
genes like me logo Genes that share ontologies with HOOK2: view

Drugs & Compounds for HOOK2 Gene

No Compound Related Data Available

Transcripts for HOOK2 Gene

Unigene Clusters for HOOK2 Gene

Hook homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOOK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
SP1: - - - - - -
SP2:
SP3: - - - - -
SP4: -
SP5:
SP6: - -
SP7: -
SP8:
SP9:
SP10:

ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for HOOK2 Gene

GeneLoc Exon Structure for
HOOK2
ECgene alternative splicing isoforms for
HOOK2

Expression for HOOK2 Gene

mRNA expression in normal human tissues for HOOK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOOK2 Gene

This gene is overexpressed in Pituitary (x4.2).

Protein differential expression in normal tissues from HIPED for HOOK2 Gene

This gene is overexpressed in Bone (63.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOOK2 Gene



SOURCE GeneReport for Unigene cluster for HOOK2 Gene Hs.30792

genes like me logo Genes that share expression patterns with HOOK2: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HOOK2 Gene

Orthologs for HOOK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOOK2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia HOOK2 35
  • 89.09 (n)
  • 92.76 (a)
HOOK2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hook2 35
  • 83.52 (n)
  • 86.31 (a)
Hook2 16
Hook2 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hook2 35
  • 83.71 (n)
  • 85.75 (a)
cow
(Bos Taurus)
Mammalia HOOK2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOOK2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOOK2 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOOK2 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOOK2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hook2 35
  • 63.89 (n)
  • 60.08 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1897 35
zebrafish
(Danio rerio)
Actinopterygii hook2 35
  • 64.55 (n)
  • 58.05 (a)
zgc66419 35
hook2 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hk 36
  • 31 (a)
OneToMany
Species with no ortholog for HOOK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOOK2 Gene

ENSEMBL:
Gene Tree for HOOK2 (if available)
TreeFam:
Gene Tree for HOOK2 (if available)

Paralogs for HOOK2 Gene

Paralogs for HOOK2 Gene

genes like me logo Genes that share paralogs with HOOK2: view

Variants for HOOK2 Gene

Sequence variations from dbSNP and Humsavar for HOOK2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs2305376 - 12,775,422(+) AGACC(C/T)GCATA intron-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs897804 - 12,766,150(-) CGCCA(C/G)CTGGA reference, missense
rs1129182 -- 12,771,068(-) GGCTG(A/G)AGAGT reference, missense
rs1205169 -- 12,765,464(+) GAAAG(A/C)AGGCC intron-variant
rs2290285 -- 12,770,713(+) GGGGG(A/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOOK2 Gene

Variant ID Type Subtype PubMed ID
dgv3733n71 CNV Loss 21882294
nsv911077 CNV Loss 21882294
nsv911079 CNV Loss 21882294
dgv3734n71 CNV Loss 21882294
esv2667754 CNV Deletion 23128226

Variation tolerance for HOOK2 Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.34; 85.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOOK2 Gene

HapMap Linkage Disequilibrium report
HOOK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOOK2 Gene

Disorders for HOOK2 Gene

Relevant External Links for HOOK2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOOK2

No disorders were found for HOOK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOOK2 Gene

Publications for HOOK2 Gene

  1. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PMID: 9927460) Kraemer H. … Phistry M. (Genetics 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for HOOK2 Gene

Sources for HOOK2 Gene

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