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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOOK2 Gene

protein-coding   GIFtS: 52
GCID: GC19M012873

Hook Microtubule-Tethering Protein 2

(Previous name: hook homolog 2 (Drosophila))
  Search for HOOK2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Hook Microtubule-Tethering Protein 21 2     Hook Homolog 2 (Drosophila)1
h-hook22 3     Hook Homolog 22
hHK22 3     Protein Hook Homolog 22
HK22 5     

External Ids:    HGNC: 198851   Entrez Gene: 299112   Ensembl: ENSG000000950667   OMIM: 6078245   UniProtKB: Q96ED93   

Export aliases for HOOK2 gene to outside databases

Previous GC identifers: GC19M013005 GC19M013096 GC19M012719 GC19M012734 GC19M012446


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOOK2 Gene:
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to
microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook
protein is a component of the endocytic compartment.(supplied by OMIM, Apr 2004)

GeneCards Summary for HOOK2 Gene: 
HOOK2 (hook microtubule-tethering protein 2) is a protein-coding gene. GO annotations related to this gene include microtubule binding and identical protein binding. An important paralog of this gene is HOOK1.

UniProtKB/Swiss-Prot: HOOK2_HUMAN, Q96ED9
Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle
trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to
the establishment and maintenance of centrosome function. May function in the positioning or formation of
aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones

summary for HOOK2 Gene:
Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose
into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial
oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which
has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer
mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as
skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation
and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose
metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for HOOK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOOK2 gene promoter:
         AREB6   SRF   p53   Egr-1   SRF (504 AA)   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): HOOK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOOK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOOK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

HOOK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOOK2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M012873:  view genomic region     (about GC identifiers)

Start:
12,873,817 bp from pter      End:
12,983,554 bp from pter
Size:
109,738 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: HOOK2_HUMAN, Q96ED9 (See protein sequence)
Recommended Name: Protein Hook homolog 2  
Size: 719 amino acids; 83207 Da
Subunit: Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2,
and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with
AKTIP/FTS, HOOK1 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS
complex) including VPS16 and VPS41; these interactions may be indirect. Interacts with CEP110. Interacts with
microtubules. Interacts with ZC3H14
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cytoplasm,
cytoskeleton. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome.
Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the
endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found
in close association with microtubules
Secondary accessions: O60562
Alternative splicing: 2 isoforms:  Q96ED9-1   Q96ED9-2   

Explore the universe of human proteins at neXtProt for HOOK2: NX_Q96ED9

Explore proteomics data for HOOK2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96ED9

  • HOOK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    HOOK2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001093646.1  NP_037444.2  

    ENSEMBL proteins: 
     ENSP00000380785   ENSP00000264827   ENSP00000465091   ENSP00000467097   ENSP00000465023  
     ENSP00000466616   ENSP00000465427   ENSP00000466497   ENSP00000467739   ENSP00000465042  

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    Cloud-Clone Corp. Proteins for HOOK2 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005813centrosome IDA17140400
    GO:0005874microtubule IEA--
    GO:0030897colocalizes with HOPS complex IDA18799622
    GO:0070695FHF complex IDA18799622

    HOOK2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008636 HOOK/CCDC88

    Graphical View of Domain Structure for InterPro Entry Q96ED9

    ProtoNet protein and cluster: Q96ED9

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB008636 HOOK


    UniProtKB/Swiss-Prot: HOOK2_HUMAN, Q96ED9
    Similarity: Belongs to the hook family


    HOOK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HOOK2_HUMAN, Q96ED9
    Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle
    trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to
    the establishment and maintenance of centrosome function. May function in the positioning or formation of
    aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0008017microtubule binding ----
    GO:0042802identical protein binding IPI18799622
         
    HOOK2 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOOK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/38 Interacting proteins for HOOK2 (Q96ED91, 2, 3 ENSP000003807854) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AKTIPQ9H8T02, 3, ENSP000003002454MINT-67661 I2D: score=5 STRING: ENSP00000300245
    APEX2Q9UBZ42, 3, ENSP000003641264MINT-67126 I2D: score=5 STRING: ENSP00000364126
    EPS8Q129292, 3, ENSP000002811724MINT-68090 I2D: score=5 STRING: ENSP00000281172
    FAM107AO959902, 3, ENSP000003542704MINT-67732 I2D: score=5 STRING: ENSP00000354270
    KAT7O952512, 3, ENSP000002590214MINT-66437 I2D: score=5 STRING: ENSP00000259021
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0006897endocytosis TAS9927460
    GO:0007032endosome organization IMP18799622
    GO:0007040lysosome organization IMP18799622
    GO:0008333endosome to lysosome transport IMP18799622

    HOOK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HOOK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    2-Deoxy-D-glucoseNon-metabolizable glucose analog; hexokinase substrate[154-17-6]
    LonidamineMitochondrial hexokinase inhibitor[50264-69-2]

    Search CenterWatch for drugs/clinical trials and news about HOOK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HOOK2 gene (2 alternative transcripts): 
    NM_001100176.1  NM_013312.2  

    Unigene Cluster for HOOK2:

    Hook homolog 2 (Drosophila)
    Hs.30792  [show with all ESTs]
    Unigene Representative Sequence: NM_013312
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000397668(uc002muy.2) ENST00000264827(uc002muz.2) ENST00000589915
    ENST00000586710 ENST00000586188 ENST00000592259 ENST00000589965 ENST00000591839
    ENST00000589398 ENST00000589400 ENST00000592079 ENST00000586284 ENST00000590839
    ENST00000586719 ENST00000588052 ENST00000587964 ENST00000587178 ENST00000592808

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    Additional mRNA sequence: 

    AF044924.1 BC012443.1 

    18 DOTS entries:

    DT.455292  DT.91763987  DT.100023232  DT.100765494  DT.95161455  DT.121433791  DT.100659045  DT.100754074 
    DT.100746086  DT.101975896  DT.75190335  DT.95161456  DT.121433801  DT.40111094  DT.91763985  DT.97767763 
    DT.100706696  DT.99931993 

    24/157 AceView cDNA sequences (see all 157):

    CK825819 BI829135 BQ774589 CR590832 AI432543 AI399962 AI204033 AI499232 
    AI648501 CA941318 BQ269738 AA553952 CK429789 AI499241 CA448702 BC012443 
    CK825820 BM982435 BI819433 BQ447998 BE165028 BE793955 CA843683 AL119893 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for HOOK2 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a ·
    SP1:                                      -     -     -     -     -                                                                             -               
    SP2:                                                                                                                                                            
    SP3:                                      -     -     -     -     -                                                                                             
    SP4:                                                                                                                                            -               
    SP5:                                                                                                                                                            

    ExUns: 17b ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23
    SP1:  -           -                                       
    SP2:  -           -                                       
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for HOOK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOOK2 expression in normal human tissues (normalized intensities)      HOOK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTGCCTCA
    HOOK2 Expression
    About this image


    HOOK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 3 entries
             Hindgut
     
     Epidermis (Integumentary System)
             Stratified Epidermis

     -- (Gastrointestinal Tract)
             visceral organ/oral region/gland   

    See HOOK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOOK2

    SOURCE GeneReport for Unigene cluster: Hs.30792
        SABiosciences Custom PCR Arrays for HOOK2
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for HOOK2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hook21 , 5 hook homolog 2 (Drosophila)1, 5 83.5(n)1
    86.29(a)1
      8 (41.44 cM)5
    1708331  NM_001167991.11  NP_001161463.11 
     849905955 
    lizard
    (Anolis carolinensis)
    Reptilia HOOK26
    hook homolog 2 (Drosophila)
    64(a)
    1 ↔ 1
    GL343286.1(891967-921510)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.18972 Xenopus laevis cDNA clone IMAGE4174467, partial cds 74.61(n)    BC060438.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc664192 similar to hook homolog 2 (Drosophila) 72.18(n)   394086  BC055648.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hk6
    hook
    31(a)
    1 → many
    2L(19030838-19033495)
    worm
    (Caenorhabditis elegans)
    Secernentea zyg-126
    Zygote defective protein 12
    14(a)
    1 → many
    II(4949900-4953488)


    ENSEMBL Gene Tree for HOOK2 (if available)
    TreeFam Gene Tree for HOOK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOOK2 gene
    HOOK12  CCDC88C2  CCDC88A2  HOOK32  CCDC88B2  
    11 SIMAP similar genes for HOOK2 using alignment to 9 protein entries:     HOOK2_HUMAN (see all proteins):
    APOPT1    ZNF527    FAM175A    CRCP    SKA2    TCF4
    ZNF547    ZNF611    HOOK3    HOOK1    C4orf21

    HOOK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/390 SNPs in HOOK2 are shown (see all 390)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs284686101,2
    C,F--12460903(+) TTCCAC/GGATAT 2 -- us2k15Minor allele frequency- G:0.14WA NA EA 362
    rs1414648461,2
    --12460915(+) CCCCCC/TGCGCC 2 -- us2k10--------
    rs1508375901,2
    --12461004(+) GCCCAC/TCAGGG 2 -- us2k10--------
    rs38485891,2
    C,F,A,H--12461085(-) CCCCCG/CCTCCA 2 -- us2k110Minor allele frequency- C:0.24NS EA NA WA 782
    rs1175822321,2
    F--12461368(+) GCGGGG/ATAATG 2 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1395281781,2
    C--12873317(+) AAAAA-/GCAAC 
     AACAACC
    AAAAA
    2 -- ds50010--------
    rs3743106121,2
    C--12873317(+) AAAAA-/GCAACAAC
    AACCAAAAAAC
    AAAAC
    2 -- ds50010--------
    rs1877446191,2
    --12873499(+) GGCATA/GATCTC 2 -- ds50010--------
    rs1924259571,2
    --12873682(+) CCACCC/TGCCTC 2 -- ds50010--------
    rs1843979351,2
    --12873725(+) GCCACC/TGTACC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for HOOK2 (12873817 - 12983554 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for HOOK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2667754CNV Deletion23128226
    nsv911077CNV Loss21882294
    nsv911079CNV Loss21882294
    dgv3733n71CNV Loss21882294
    dgv3734n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HOOK2 for disorders           About MalaCards
    OMIM gene information: 607824    OMIM disorders: --


    HOOK2 for disorders           About GeneDecksing


    Export disorders for HOOK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOOK2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with HOOK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PubMed id 9927460)1, 2, 3 Kraemer H. and Phistry M. (1999)
    2. SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. (PubMed id 19273536)1, 2 Guthrie C.R....Kraemer B.C. (2009)
    3. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PubMed id 18799622)1, 2 Xu L....Harper J.W. (2008)
    4. Hook2 contributes to aggresome formation. (PubMed id 17540036)1, 2 Szebenyi G....Kraemer H. (2007)
    5. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. (PubMed id 17140400)1, 2 Szebenyi G.... Kraemer H. (2007)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PubMed id 11238449)1, 2 Walenta J.H.... Kraemer H. (2001)
    8. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
    9. Hook2 is involved in the morphogenesis of the primary cilium. (PubMed id 21998199)1 Baron Gaillard C.L....Le Bivic A. (2011)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29911 HGNC: 19885 AceView: HOOK2 Ensembl:ENSG00000095066 euGenes: HUgn29911
    ECgene: HOOK2 H-InvDB: HOOK2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOOK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HOOK2 gene:
    Search GeneIP for patents involving HOOK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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