Aliases for HOOK1 Gene
Aliases for HOOK1 Gene
External Ids for HOOK1 Gene
- HGNC: 19884
- Entrez Gene: 51361
- Ensembl: ENSG00000134709
- OMIM: 607820
- UniProtKB: Q9UJC3
Previous GeneCards Identifiers for HOOK1 Gene
- GC01P060206
- GC01P059203
- GC01P059638
- GC01P059650
- GC01P059992
- GC01P060280
- GC01P058391
Summaries for HOOK1 Gene
-
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for HOOK1 Gene
HOOK1 (Hook Microtubule Tethering Protein 1) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and actin binding. An important paralog of this gene is HOOK3.
UniProtKB/Swiss-Prot for HOOK1 Gene
-
Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOOK1 Gene
Genomics for HOOK1 Gene
Regulatory Elements for HOOK1 Gene
Enhancers for HOOK1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH01G059856 | 0.9 | ENCODE | 17.7 | +42.4 | 42418 | 2.2 | ELF3 TBP FOXA2 MLX ARID4B DMAP1 DNMT3B THRB ZNF48 RARA | HOOK1 GC01P059852 GC01M059897 |
| GH01G059750 | 1.2 | Ensembl ENCODE dbSUPER | 9.9 | -64.0 | -63963 | 1.2 | JUN MAX ZNF384 FOSL1 GATA2 EGR1 FOSL2 FOS MAFK BHLHE40 | HOOK1 MIR4711 LOC101926944 |
| GH01G059758 | 1.1 | Ensembl ENCODE | 10.7 | -55.3 | -55256 | 1.3 | ELF3 PKNOX1 WRNIP1 ARID4B SIN3A ZNF76 ZNF2 ZNF48 RAD21 YY1 | HOOK1 LOC101926944 MIR4711 |
| GH01G059879 | 0.7 | ENCODE | 15.3 | +65.5 | 65467 | 1.2 | CTCF PKNOX1 ZNF654 JUN MNT RAD21 YY1 FOXA1 GATA2 CEBPA | HOOK1 GC01M059897 GC01P059852 |
| GH01G059814 | 1.1 | ENCODE | 8.3 | +0.3 | 299 | 1.8 | HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 | HOOK1 LOC105378758 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOOK1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOOK1 gene promoter:
Regulatory Element Products
Genomic Location for HOOK1 Gene
- Chromosome:
- 1
- Start:
- 59,814,786 bp from pter
- End:
- 59,876,378 bp from pter
- Size:
- 61,593 bases
- Orientation:
- Plus strand
Genomic View for HOOK1 Gene
Genes around HOOK1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p32.1 by Ensembl
- 1p32.1 by Entrez Gene
- 1p32.1 by HGNC
HOOK1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOOK1 Gene
Proteins for HOOK1 Gene
-
Protein details for HOOK1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UJC3-HOOK1_HUMAN
- Recommended name:
- Protein Hook homolog 1
- Protein Accession:
- Q9UJC3
- A8K8E9
- A8MU44
- B4DX15
- O60561
- Q5TG44
Protein attributes for HOOK1 Gene
- Size:
- 728 amino acids
- Molecular mass:
- 84648 Da
- Quaternary structure:
-
- Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK2 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16, VPS18, VPS39 and VPS41; these interactions may be indirect. Interacts with microtubules.
Protein Expression for HOOK1 Gene
Post-translational modifications for HOOK1 Gene
Other Protein References for HOOK1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOOK1
- Invitrogen Antibodies for HOOK1
- antibodies-online Antibodies for HOOK1: See all 52
- GeneTex HOOK1 antibody for HOOK1
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOOK1
Protein Products
-
OriGene Purified Proteins for HOOK1
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- antibodies-online Proteins for HOOK1: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOOK1
Assay Products
No data available for DME Specific Peptides for HOOK1 Gene
Domains & Families for HOOK1 Gene
Protein Domains for HOOK1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOOK1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UJC3- Family:
-
- Belongs to the hook family.
No data available for Gene Families for HOOK1 Gene
Function for HOOK1 Gene
Molecular function for HOOK1 Gene
- UniProtKB/Swiss-Prot Function:
- Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (PubMed:18799622).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 15471887 |
| GO:0008017 | microtubule binding | IEA,IBA | -- |
| GO:0042802 | identical protein binding | IPI | 18799622 |
| GO:0051959 | dynein light intermediate chain binding | IBA | -- |
Phenotypes for HOOK1 Gene
- MGI mutant phenotypes for HOOK1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOOK1:
Animal Model Products
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-
ViGene Biosciences lentiviral particle packaged cDNA for HOOK1 gene
-
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- Search ViGene Biosciences for HOOK1
CRISPR Products
-
OriGene CRISPR knockouts for HOOK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOOK1
- GenScript: Design CRISPR guide RNA sequences for HOOK1
miRNA for HOOK1 Gene
- miRTarBase miRNAs that target HOOK1
-
- hsa-mir-335-5p (MIRT017608)
- hsa-mir-1-3p (MIRT023735)
- hsa-mir-93-5p (MIRT028032)
- hsa-mir-190a-3p (MIRT194394)
- hsa-mir-5011-5p (MIRT194395)
- hsa-mir-584-5p (MIRT282702)
- hsa-mir-758-5p (MIRT282703)
- hsa-mir-3120-3p (MIRT282704)
- hsa-mir-218-2-3p (MIRT282721)
- hsa-mir-139-5p (MIRT441808)
- hsa-mir-4762-5p (MIRT441809)
- hsa-mir-1277-5p (MIRT557190)
- hsa-mir-4719 (MIRT557191)
- hsa-mir-7705 (MIRT557192)
- hsa-mir-4538 (MIRT557193)
- hsa-mir-4453 (MIRT557194)
- hsa-mir-548l (MIRT557195)
- hsa-mir-548n (MIRT557196)
- hsa-mir-4764-3p (MIRT657323)
- hsa-mir-3160-5p (MIRT670312)
miRNA Products
- Search ViGene Biosciences for HOOK1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOOK1
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-
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Clone Products
-
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Cell Line Products
-
Horizon Cell Lines for HOOK1
-
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-
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-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HOOK1 Gene
Localization for HOOK1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOOK1 Gene
- Cytoplasm, cytoskeleton. Cytoplasm. Note=Localizes to the spermatid manchette during spermiogenesis but is not present in mature spermatozoa (By similarity). Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 4 |
| cytosol | 4 |
| nucleus | 2 |
| endosome | 2 |
| lysosome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005813 | centrosome | IBA | -- |
| GO:0005829 | cytosol | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA | -- |
Pathways & Interactions for HOOK1 Gene
No Data Available
Interacting Proteins for HOOK1 Gene
Selected Interacting proteins:
ENSP00000360252
Q9UJC3-HOOK1_HUMAN
for HOOK1 Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0007032 | endosome organization | IMP | 18799622 |
| GO:0007040 | lysosome organization | IMP | 18799622 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOOK1 Gene
Transcripts for HOOK1 Gene
mRNA/cDNA for HOOK1 Gene
- (5) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (121) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HOOK1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HOOK1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOOK1
- GenScript: Design CRISPR guide RNA sequences for HOOK1
miRNA Products
- Search ViGene Biosciences for HOOK1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOOK1
- Browse OriGene Inhibitory RNA Products For HOOK1
-
ViGene Biosciences ready-to-package AAV shRNAs for HOOK1 gene
Clone Products
-
OriGene ORF clones in human for HOOK1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for HOOK1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: |
| ExUns: | 21 | ^ | 22 | ^ | 23 |
|---|---|---|---|---|---|
| SP1: | |||||
| SP2: | |||||
| SP3: | |||||
| SP4: |
Expression for HOOK1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Gonad
- Elongated Spermatid Seminiferous Tubules
- XX Germ Cells Ovigerous Cord
- XY Germ Cells Testis Cord
-
Testis (Reproductive System)
- Elongated Spermatid Seminiferous Tubules
- XY Germ Cells Testis Cord
-
Liver (Hepatobiliary System)
- Hematopoietic Stem Cells Liver Bud
-
Blood (Cardiovascular System)
- Hematopoietic Stem Cells Liver Bud
-
Ovary (Reproductive System)
- XX Germ Cells Ovigerous Cord
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
mRNA differential expression in normal tissues according to GTEx for HOOK1 Gene
This gene is overexpressed in Testis (x4.8).
This gene is overexpressed in Cervix (21.4), Salivary gland (7.0), and Pancreas (6.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOOK1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOOK1 Gene:
HOOK1SOURCE GeneReport for Unigene cluster for HOOK1 Gene:
Hs.378836Evidence on tissue expression from TISSUES for HOOK1 Gene
- Liver(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for HOOK1
-
OriGene qPCR primer pairs for HOOK1
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOOK1 Gene
Orthologs for HOOK1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOOK1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOOK1 35 |
|
OneToOne | |
| LOC785042 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | HOOK1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Hook1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Hook1 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOOK1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | HOOK1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | HOOK1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | HOOK1 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | hook1 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | hk 36 35 |
|
- Species where no ortholog for HOOK1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOOK1 Gene
(2) SIMAP similar genes for HOOK1 Gene using alignment to 4 proteins:
Variants for HOOK1 Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035709 | A breast cancer sample | ||||
| rs1000014814 | -- | 59,841,247(+) | ATGCT(C/G)TATGT | intron-variant | |
| rs1000027373 | -- | 59,846,731(+) | AACTT(C/T)TTCTA | intron-variant | |
| rs1000072229 | -- | 59,850,418(+) | TTTTT(C/T)GGTGA | intron-variant | |
| rs1000102808 | -- | 59,861,995(+) | TTATC(A/G)TCTTA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3586193 | CNV | loss | 21293372 |
| nsv1012703 | CNV | gain | 25217958 |
| nsv477576 | CNV | novel sequence insertion | 20440878 |
| nsv819901 | CNV | loss | 19587683 |
Residual Variation Intolerance Score:
10.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.55;
44.39% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOOK1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOOK1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOOK1 Gene
Disorders for HOOK1 Gene
Relevant External Links for HOOK1
No disorders were found for HOOK1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOOK1 Gene
Publications for HOOK1 Gene
- An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PMID: 18799622) Xu L. … Harper J.W. (Mol. Biol. Cell 2008) 3 4 22 64
- Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PMID: 9927460) Kraemer H. … Phistry M. (Genetics 1999) 2 3 4 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
Products for HOOK1 Gene
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- antibodies-online Antibodies for HOOK1: See all 52
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- antibodies-online Proteins for HOOK1: See all 7
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- ViGene Biosciences adenoviral particle packaged cDNA for HOOK1 gene
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- VectorBuilder custom plasmid, inducible vectors for HOOK1
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOOK1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
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