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Aliases for HOOK1 Gene

Aliases for HOOK1 Gene

  • Hook Microtubule-Tethering Protein 1 2 3
  • H-Hook1 3 4
  • HHK1 3 4
  • HK1 3 6
  • Hook Homolog 1 (Drosophila) 2
  • Protein Hook Homolog 1 3
  • Hook Homolog 1 3

External Ids for HOOK1 Gene

Summaries for HOOK1 Gene

Entrez Gene Summary for HOOK1 Gene

  • This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOOK1 Gene

HOOK1 (Hook Microtubule-Tethering Protein 1) is a Protein Coding gene. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include identical protein binding and microtubule binding. An important paralog of this gene is CCDC88A.

UniProtKB/Swiss-Prot for HOOK1 Gene

  • Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).

Gene Wiki entry for HOOK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOOK1 Gene

Genomics for HOOK1 Gene

Genomic Location for HOOK1 Gene

Start:
59,814,786 bp from pter
End:
59,876,378 bp from pter
Size:
61,593 bases
Orientation:
Plus strand

Genomic View for HOOK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOOK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOOK1 Gene

Regulatory Elements for HOOK1 Gene

Proteins for HOOK1 Gene

  • Protein details for HOOK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJC3-HOOK1_HUMAN
    Recommended name:
    Protein Hook homolog 1
    Protein Accession:
    Q9UJC3
    Secondary Accessions:
    • A8K8E9
    • A8MU44
    • B4DX15
    • O60561
    • Q5TG44

    Protein attributes for HOOK1 Gene

    Size:
    728 amino acids
    Molecular mass:
    84648 Da
    Quaternary structure:
    • Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS, HOOK2 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex) including VPS16, VPS18, VPS39 and VPS41; these interactions may be indirect. Interacts with microtubules.

    Alternative splice isoforms for HOOK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOOK1 Gene

Proteomics data for HOOK1 Gene at MOPED

Post-translational modifications for HOOK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOOK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOOK1 Gene

Domains for HOOK1 Gene

Protein Domains for HOOK1 Gene

UniProtKB/Swiss-Prot:

HOOK1_HUMAN
Family:
  • Belongs to the hook family.:
    • Q9UJC3
genes like me logo Genes that share domains with HOOK1: view

No data available for Gene Families for HOOK1 Gene

Function for HOOK1 Gene

Molecular function for HOOK1 Gene

UniProtKB/Swiss-Prot Function: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex).

Gene Ontology (GO) - Molecular Function for HOOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 15471887
GO:0042802 identical protein binding IPI 18799622
genes like me logo Genes that share ontologies with HOOK1: view

Phenotypes for HOOK1 Gene

genes like me logo Genes that share phenotypes with HOOK1: view

miRNA for HOOK1 Gene

miRTarBase miRNAs that target HOOK1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HOOK1 Gene

Localization for HOOK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOOK1 Gene

Cytoplasm, cytoskeleton. Cytoplasm. Note=Localizes to the spermatid manchette during spermiogenesis but is not present in mature spermatozoa (By similarity). Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOOK1 Gene COMPARTMENTS Subcellular localization image for HOOK1 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
endosome 2
nucleus 2
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HOOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton --
GO:0030897 colocalizes_with HOPS complex IDA 18799622
GO:0070695 FHF complex IDA 18799622
genes like me logo Genes that share ontologies with HOOK1: view

Pathways for HOOK1 Gene

genes like me logo Genes that share pathways with HOOK1: view

Gene Ontology (GO) - Biological Process for HOOK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0007275 multicellular organismal development IEA --
GO:0007286 spermatid development IEA --
GO:0008333 endosome to lysosome transport IMP 18799622
genes like me logo Genes that share ontologies with HOOK1: view

Transcripts for HOOK1 Gene

Unigene Clusters for HOOK1 Gene

Hook homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOOK1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - -
SP2:
SP3:
SP4:

ExUns: 21 ^ 22 ^ 23
SP1:
SP2:
SP3:
SP4:

Relevant External Links for HOOK1 Gene

GeneLoc Exon Structure for
HOOK1
ECgene alternative splicing isoforms for
HOOK1

Expression for HOOK1 Gene

mRNA expression in normal human tissues for HOOK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOOK1 Gene

This gene is overexpressed in Testis (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOOK1 Gene

SOURCE GeneReport for Unigene cluster for HOOK1 Gene Hs.378836

genes like me logo Genes that share expressions with HOOK1: view

Orthologs for HOOK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOOK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOOK1 36
  • 99.77 (n)
  • 99.86 (a)
HOOK1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOOK1 37
  • 95 (a)
OneToOne
LOC785042 36
  • 92.31 (n)
  • 95.74 (a)
dog
(Canis familiaris)
Mammalia HOOK1 36
  • 93.64 (n)
  • 95.88 (a)
HOOK1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hook1 36
  • 87.11 (n)
  • 93.14 (a)
Hook1 16
Hook1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOOK1 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOOK1 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hook1 36
  • 86.18 (n)
  • 93.14 (a)
chicken
(Gallus gallus)
Aves HOOK1 36
  • 77.02 (n)
  • 79.24 (a)
HOOK1 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOOK1 37
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hook1 36
  • 63.45 (n)
  • 65.91 (a)
hook1 37
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta hk 37
  • 33 (a)
OneToMany
hk 38
  • 31 (a)
Species with no ortholog for HOOK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOOK1 Gene

ENSEMBL:
Gene Tree for HOOK1 (if available)
TreeFam:
Gene Tree for HOOK1 (if available)

Paralogs for HOOK1 Gene

Paralogs for HOOK1 Gene

Selected SIMAP similar genes for HOOK1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HOOK1: view

Variants for HOOK1 Gene

Sequence variations from dbSNP and Humsavar for HOOK1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs616704 -- 59,854,040(+) tatat(A/T)ttttt intron-variant
rs618716 -- 59,834,148(+) TAATC(A/C/G)GTTTC intron-variant
rs629636 -- 59,819,442(-) CTGGG(C/T)GCAGT intron-variant
rs1051145 -- 59,876,076(+) GTGAA(C/T)GTATG utr-variant-3-prime
rs1924655 -- 59,867,461(+) TTCTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOOK1 Gene

Variant ID Type Subtype PubMed ID
nsv819901 CNV Loss 19587683

Relevant External Links for HOOK1 Gene

HapMap Linkage Disequilibrium report
HOOK1

Disorders for HOOK1 Gene

(1) University of Copenhagen DISEASES for HOOK1 Gene

Relevant External Links for HOOK1

Genetic Association Database (GAD)
HOOK1
Human Genome Epidemiology (HuGE) Navigator
HOOK1
genes like me logo Genes that share disorders with HOOK1: view

No data available for UniProtKB/Swiss-Prot for HOOK1 Gene

Publications for HOOK1 Gene

  1. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PMID: 18799622) Xu L. … Harper J.W. (Mol. Biol. Cell 2008) 3 4 23
  2. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PMID: 9927460) Kraemer H. … Phistry M. (Genetics 1999) 2 3 4
  3. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PMID: 11238449) Walenta J.H. … Kraemer H. (J. Cell Biol. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HOOK1 Gene

Sources for HOOK1 Gene

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