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HOOK1 Gene

protein-coding   GIFtS: 58
GCID: GC01P060280

Hook Microtubule-Tethering Protein 1

(Previous name: hook homolog 1 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Hook Microtubule-Tethering Protein 11 2     Hook Homolog 1 (Drosophila)1
h-hook12 3     Hook Homolog 12
hHK12 3     Protein Hook Homolog 12
HK12 5     

External Ids:    HGNC: 198841   Entrez Gene: 513612   Ensembl: ENSG000001347097   OMIM: 6078205   UniProtKB: Q9UJC33   

Export aliases for HOOK1 gene to outside databases

Previous GC identifers: GC01P060206 GC01P059203 GC01P059638 GC01P059650 GC01P059992 GC01P058391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOOK1 Gene:
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles
through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate
subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It
is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced
transcript variants have been identified, but the full-length nature of some of these variants has not been
determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOOK1 Gene:
HOOK1 (hook microtubule-tethering protein 1) is a protein-coding gene. GO annotations related to this gene include microtubule binding and identical protein binding. An important paralog of this gene is HOOK2.

UniProtKB/Swiss-Prot: HOOK1_HUMAN, Q9UJC3
Function: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the
manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP
complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the
homotypic vesicular protein sorting complex (the HOPS complex)

summary for HOOK1 Gene:
Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose
into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial
oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which
has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer
mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as
skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation
and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose
metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for HOOK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOOK1 gene promoter:
         TBP   Pax-2   Pax-2a   AP-4   Egr-2   TFIID   ATF6   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOOK1 promoter sequence
   Search Chromatin IP Primers for HOOK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOOK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.1   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32.1

HOOK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOOK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P060280:  view genomic region     (about GC identifiers)

Start:
60,280,458 bp from pter      End:
60,342,050 bp from pter
Size:
61,593 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HOOK1_HUMAN, Q9UJC3 (See protein sequence)
Recommended Name: Protein Hook homolog 1  
Size: 728 amino acids; 84648 Da
Subunit: Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2,
and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with
AKTIP/FTS, HOOK2 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS
complex) including VPS16, VPS18, VPS39 and VPS41; these interactions may be indirect. Interacts with microtubules
Secondary accessions: A8K8E9 O60561 Q5TG44

Explore the universe of human proteins at neXtProt for HOOK1: NX_Q9UJC3

Explore proteomics data for HOOK1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOOK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056972.1  
    ENSEMBL proteins: 
     ENSP00000398860   ENSP00000360252   ENSP00000378928  

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    antibodies-online proteins for HOOK1 (5 products) 

     
    antibodies-online peptides for HOOK1

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    antibodies-online antibodies for HOOK1 (43 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008636 Hook-related_fam

    Graphical View of Domain Structure for InterPro Entry Q9UJC3

    ProtoNet protein and cluster: Q9UJC3

    2 Blocks protein domains:
    IPB001715 Calponin-like actin-binding
    IPB008636 HOOK


    UniProtKB/Swiss-Prot: HOOK1_HUMAN, Q9UJC3
    Similarity: Belongs to the hook family


    Find genes that share domains with HOOK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HOOK1_HUMAN, Q9UJC3
    Function: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the
    manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP
    complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the
    homotypic vesicular protein sorting complex (the HOPS complex)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI15471887
    GO:0008017microtubule binding ----
    GO:0042802identical protein binding IPI18799622
         
    Find genes that share ontologies with HOOK1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for HOOK1:
     Increased number of cells in m 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Hook1):
     reproductive system 

    Find genes that share phenotypes with HOOK1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HOOK1

    miRNA
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    miRTarBase miRNAs that target HOOK1:
    hsa-mir-1 (MIRT023735), hsa-mir-335-5p (MIRT017608), hsa-mir-93-5p (MIRT028032)

    Block miRNA regulation of human, mouse, rat HOOK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOOK1 (see all 42):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-4307 hsa-let-7d hsa-miR-429 hsa-miR-218 hsa-let-7g hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmidHOOK1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HOOK1_HUMAN, Q9UJC3: Cytoplasm, cytoskeleton (By similarity). Cytoplasm. Note=Localizes to the spermatid
    manchette during spermiogenesis but is not present in mature spermatozoa (By similarity). Localizes to punctate
    cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the
    Golgi complex, multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with
    microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol2
    endosome2
    nucleus2
    plasma membrane1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IEA--
    GO:0030897colocalizes with HOPS complex IDA18799622
    GO:0070695FHF complex IDA18799622

    Find genes that share ontologies with HOOK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HOOK1
    Interactions:

        GeneGlobe Interaction Network for HOOK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for HOOK1 (Q9UJC32, 3 ENSP000003602524) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF250P156223, ENSP000002925794I2D: score=4 STRING: ENSP00000292579
    AKTIPQ9H8T03, ENSP000003002454I2D: score=3 STRING: ENSP00000300245
    FAM160A2Q8N6123, ENSP000002659784I2D: score=1 STRING: ENSP00000265978
    VPS16Q9H2693, ENSP000003698104I2D: score=1 STRING: ENSP00000369810
    VPS18Q9P2533, ENSP000002205094I2D: score=1 STRING: ENSP00000220509
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007032endosome organization IMP18799622
    GO:0007040lysosome organization IMP18799622
    GO:0007275multicellular organismal development IEA--
    GO:0007286spermatid development IEA--
    GO:0008333endosome to lysosome transport IMP18799622

    Find genes that share ontologies with HOOK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for HOOK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    2-Deoxy-D-glucoseNon-metabolizable glucose analog; hexokinase substrate[154-17-6]
    LonidamineMitochondrial hexokinase inhibitor[50264-69-2]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOOK1 gene: 
    NM_015888.4  

    Unigene Cluster for HOOK1:

    Hook homolog 1 (Drosophila)
    Hs.378836  [show with all ESTs]
    Unigene Representative Sequence: NM_015888
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455990 ENST00000371208(uc009wad.3 uc001czo.3 uc001czp.3 uc010oor.2)
    ENST00000465876 ENST00000474695 ENST00000466803 ENST00000491135 ENST00000395561

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    hsa-miR-576-3p hsa-miR-607 hsa-miR-4307 hsa-let-7d hsa-miR-429 hsa-miR-218 hsa-let-7g hsa-miR-383
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    Additional mRNA sequence: 

    AF044923.1 AK027250.1 AK097735.1 AK098561.1 AK292314.1 AK301768.1 BC011621.2 BC107857.1 

    7 DOTS entries:

    DT.451662  DT.100018792  DT.92407301  DT.95157970  DT.121446717  DT.75106174  DT.92417254 

    Selected AceView cDNA sequences (see all 121):

    AK027250 AL695058 AK098561 NM_015888 C16985 BE857702 AW513053 BM784031 
    BM756288 N73622 CB139799 AI521884 AW341697 AI800210 BX118356 BC011621 
    AI523745 BM697710 H40247 AI963345 T56535 BM798083 BF724509 CB159448 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HOOK1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                    -                                                     -                                                                 -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  


    ECgene alternative splicing isoforms for HOOK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOOK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTATACAC
    HOOK1 Expression
    About this image


    HOOK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             Human embryonic stem cells (family)
     
     Gonad
             XY Germ Cells Testis Cord
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Bone (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Mesenchymal Condensate Cells Zeugopod
    HOOK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOOK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.378836
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOOK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOOK1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hook11 , 5 hook homolog 1 (Drosophila)1, 5 87.11(n)1
    93.14(a)1
      4 (44.17 cM)5
    779631  NM_030014.21  NP_084290.11 
     959672405 
    chicken
    (Gallus gallus)
    Aves HOOK11 hook homolog 1 (Drosophila) 77.02(n)
    79.24(a)
      424675  NM_001006542.1  NP_001006542.1 
    lizard
    (Anolis carolinensis)
    Reptilia HOOK16
    hook microtubule-tethering protein 1
    82(a)
    1 ↔ 1
    4(101436546-101483348)
    zebrafish
    (Danio rerio)
    Actinopterygii hook11 hook homolog 1 63.45(n)
    65.91(a)
      570393  NM_001045198.1  NP_001038663.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hk3 endocytosis 31(a)   2 37B10   --


    ENSEMBL Gene Tree for HOOK1 (if available)
    TreeFam Gene Tree for HOOK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOOK1 gene
    HOOK22  CCDC88C2  CCDC88A2  HOOK32  CCDC88B2  
    2 SIMAP similar genes for HOOK1 using alignment to 4 protein entries:     HOOK1_HUMAN (see all proteins):
    HOOK3    HOOK2

    Find genes that share paralogs with HOOK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOOK1 (see all 1148)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357094
    A breast cancer sample4--see VAR_0357092 S L mis40--------
    rs74186511,2
    C,F,A,H--60354328(+) ACTGAA/C/TGCAGA 1 -- us2k112NS EA NA 1256
    rs1862454841,2
    --60354329(+) CTGACA/GCAGAA 1 -- us2k10--------
    rs1513369961,2
    --60354350(+) TCATGG/TGTTTA 1 -- us2k10--------
    rs1901533561,2
    --60354390(+) TAAAAA/TTTGTT 1 -- us2k10--------
    rs1831510541,2
    --60354416(+) TGATAA/GTTTAC 1 -- us2k10--------
    rs37542011,2
    C,F--60354425(+) ACTCTC/ATATAA 1 -- us2k11Minor allele frequency- A:0.02EA 924
    rs1399224971,2
    C--60354453(+) AATTG-/CCCCCC 1 -- us2k10--------
    rs1458690331,2
    --60354515(+) TGGCTC/TTCAGT 1 -- us2k10--------
    rs1874867691,2
    --60354820(+) GTCAAC/TAGCAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOOK1 (60280458 - 60342050 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for HOOK1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819901CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOOK1
    DNA2.0 Custom Variant and Variant Library Synthesis for HOOK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607820    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HOOK1:
    Batten disease

    Find genes that share disorders with HOOK1           About GenesLikeMe

    Genetic Association Database (GAD): HOOK1
    Human Genome Epidemiology (HuGE) Navigator: HOOK1 (1 document)

    Export disorders for HOOK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOOK1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with HOOK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PubMed id 9927460)1, 2, 3 Kraemer H. and Phistry M. (Genetics 1999)
    2. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PubMed id 18799622)1, 2, 9 Xu L.... Harper J.W. (Mol. Biol. Cell 2008)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PubMed id 11238449)1, 2 Walenta J.H.... Kraemer H. (J. Cell Biol. 2001)
    9. Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway. (PubMed id 15471887)1, 9 Luiro K....Jalanko A. (Hum. Mol. Genet. 2004)
    10. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51361 HGNC: 19884 AceView: HOOK1 Ensembl:ENSG00000134709 euGenes: HUgn51361
    ECgene: HOOK1 H-InvDB: HOOK1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for HOOK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HOOK1 gene:
    Search GeneIP for patents involving HOOK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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