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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOOK1 Gene

protein-coding   GIFtS: 56
GCID: GC01P060280

hook homolog 1 (Drosophila)
 Explore 2 diseases affiliated with
HOOK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOOK1    

Aliases
for HOOK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Hook Homolog 1 (Drosophila)1 2
HK11 2 5
H-Hook11
HHK11
Protein Hook Homolog 12

External Ids:    HGNC: 198841   Entrez Gene: 513612   Ensembl: ENSG000001347097   OMIM: 6078205   UniProtKB: Q9UJC33   

Export aliases for HOOK1 gene to outside databases

Previous GC identifers: GC01P060206 GC01P059203 GC01P059638 GC01P059650 GC01P059992 GC01P058391


Summaries
for HOOK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOOK1:
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles
through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular
structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link
endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have
been identified, but the full-length nature of some of these variants has not been determined. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: HOOK1_HUMAN, Q9UJC3
Function: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the
manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP
complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic
vesicular protein sorting complex (the HOPS complex)

summary for HOOK1:
Mitochondrial Hexokinases catalyze the first essential step of glucose metabolism, the conversion of glucose
into glucose-6-phosphate. This directly couples extramitochondrial glycolysis to intramitochondrial
oxidative phosphorylation. There are two subtypes of mitochondrial hexokinases, HK1 and HK2, each of which
has four isozymes designated hexokinase I, II, III and IV. HK1 and HK2 are both localized to the outer
mitochondrial membrane, with HK1 being found in nervous tissue and HK2 in insulin-responsive tissues such as
skeletal muscle. Activation of mitochondrial hexokinases is regulated by Akt/PKB-mediated phosphorylation
and they are subject to inhibiton by their end product, glucose-6-phosphate. In addition to glucose
metabolism, mitochondrial hexokinases have been implicated in antiapoptotic and cell survival signaling.

Gene Wiki entry for HOOK1


Genomic Views
for HOOK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOOK1 gene promoter:
         TBP   Pax-2   Pax-2a   AP-4   Egr-2   TFIID   ATF6   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOOK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOOK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOOK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32.1   Ensembl cytogenetic band:  1p32.1   HGNC cytogenetic band: 1p32.1

HOOK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOOK1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P060280:  view genomic region     (about GC identifiers)

Start:
 60,280,458 bp from pter      End:
 60,342,050 bp from pter
Size:
 61,593 bases      Orientation:
 plus strand

Proteins
for HOOK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HOOK1_HUMAN, Q9UJC3 (See protein sequence)
Recommended Name: Protein Hook homolog 1  
Size: 728 amino acids; 84648 Da
Subunit: Self-associates. Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and
one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with AKTIP/FTS,
HOOK2 and HOOK3. Associates with several subunits of the homotypic vesicular sorting complex (the HOPS complex)
including VPS16, VPS18, VPS39 and VPS41; these interactions may be indirect. Interacts with microtubules
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cytoplasm. Note=Localizes to the spermatid manchette
during spermiogenesis but is not present in mature spermatozoa (By similarity). Localizes to punctate cytoplasmic foci
which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, the Golgi complex,
multivesicular bodies (MVBs), lysosomes, or mitochondria. Often found in close association with microtubules
Secondary accessions: A8K8E9 O60561 Q5TG44

Explore the universe of human proteins at neXtProt for HOOK1: NX_Q9UJC3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UJC3

    • HOOK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056972.1  
    ENSEMBL proteins: 
     ENSP00000398860   ENSP00000360252   ENSP00000378928  

    Human Recombinant Protein Products: 
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    Novus Biologicals HOOK1 Proteins
    Novus Biologicals HOOK1 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HOOK1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005874microtubule IEA--
    GO:0030897colocalizes with HOPS complex IDA18799622
    GO:0070695FHF complex IDA18799622


    HOOK1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HOOK1

    Protein Domains /
    Families
    for HOOK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOOK1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR008636 HOOK

    Graphical View of Domain Structure for InterPro Entry Q9UJC3

    ProtoNet protein and cluster: Q9UJC3

    2 Blocks protein families:
    IPB001715 Calponin-like actin-binding
    IPB008636 HOOK


    UniProtKB/Swiss-Prot: HOOK1_HUMAN, Q9UJC3
    Similarity: Belongs to the hook family


    Function
    for HOOK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HOOK1_HUMAN, Q9UJC3
    Function: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the
    manchette and the flagellum in relation to the membrane skeleton (By similarity). Component of the FTS/Hook/FHIP
    complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic
    vesicular protein sorting complex (the HOPS complex)

    miRNA
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    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate HOOK1 (see all 42):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-4307 hsa-let-7d hsa-miR-429 hsa-miR-218 hsa-let-7g hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: HOOK1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI18799622
    GO:0008017microtubule binding IEA--
    GO:0042802identical protein binding IPI18799622


    HOOK1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HOOK1:
     Increased number of cells in m 

    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Hook1):
     reproductive system 

    HOOK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for HOOK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOOK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/18 Interacting proteins for HOOK1 (Q9UJC32, 3 ENSP000003602524) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF250P156223, ENSP000002925794I2D: score=4 STRING: ENSP00000292579
    AKTIPQ9H8T03, ENSP000003002454I2D: score=3 STRING: ENSP00000300245
    FAM160A2Q8N6123, ENSP000002659784I2D: score=1 STRING: ENSP00000265978
    VPS16Q9H2693, ENSP000003698104I2D: score=1 STRING: ENSP00000369810
    VPS18Q9P2533, ENSP000002205094I2D: score=1 STRING: ENSP00000220509
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0007032endosome organization IMP18799622
    GO:0007040lysosome organization IMP18799622
    GO:0007275multicellular organismal development IEA--
    GO:0007286spermatid development IEA--


    HOOK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOOK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for HOOK1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    LonidamineMitochondrial hexokinase inhibitor[50264-69-2]
    Search CenterWatch for drugs/clinical trials and news about HOOK1 

    Transcripts
    for HOOK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOOK1 gene: 
    NM_015888.4  

    Unigene Cluster for HOOK1:

    Hook homolog 1 (Drosophila)
    Hs.378836  [show with all ESTs]
    Unigene Representative Sequence: NM_015888
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000455990 ENST00000371208(uc009wad.3 uc001czo.3 uc001czp.3 uc010oor.2)
    ENST00000465876 ENST00000474695 ENST00000466803 ENST00000491135 ENST00000395561


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOOK1
    8/42 QIAGEN miScript miRNA Assays for microRNAs that regulate HOOK1 (see all 42):
    hsa-miR-576-3p hsa-miR-607 hsa-miR-4307 hsa-let-7d hsa-miR-429 hsa-miR-218 hsa-let-7g hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: HOOK1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOOK1 (see all 7)
    OriGene shRNA RFP: HOOK1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF044923.1 AK027250.1 AK097735.1 AK098561.1 AK292314.1 AK301768.1 BC011621.2 BC107857.1 

    7 DOTS entries:

    DT.451662  DT.100018792  DT.92407301  DT.95157970  DT.121446717  DT.75106174  DT.92417254 

    24/121 AceView cDNA sequences (see all 121):

    BE218040 AA707590 BM784031 BM756288 BF035311 N73622 BE857702 NM_015888 
    AW341697 AL695058 AI521884 CB139799 BX118356 AI523745 BI793183 BC011621 
    C16985 AK098561 AK027250 AI348407 T56535 AI963345 H40247 AI989616 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HOOK1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
    SP1:                    -                                                     -                                                                 -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            

    ExUns: 21 ^ 22 ^ 23
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  


    ECgene alternative splicing isoforms for HOOK1

    Expression
    for HOOK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOOK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTATACAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    HOOK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesElongated SpermatidGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See HOOK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOOK1

    SOURCE GeneReport for Unigene cluster: Hs.378836
        SABiosciences Custom PCR Arrays for HOOK1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOOK1

    Orthologs
    for HOOK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOOK1 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOOK11 hook homolog 1 (Drosophila) 77.39(n)
    79.69(a)    		   424675  NM_001006542.1  NP_001006542.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HOOK16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 4(101439236-101483049)
    zebrafish
    (Danio rerio)    		 Actinopterygii hook11 hook homolog 1 63.79(n)
    66.1(a)    		   570393  NM_001045198.1  NP_001038663.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta hk3 endocytosis 31(a)   2 37B10   --
    worm
    (Caenorhabditis elegans)    		 Secernentea zyg-121 ZYGote defective: embryonic lethal 42.47(n)
    25.29(a)    		   3565765  NM_001027351.2  NP_001022522.1 


    ENSEMBL Gene Tree for HOOK1 (if available)
    TreeFam Gene Tree for HOOK1 (if available) 

    Paralogs
    for HOOK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOOK1 gene
    HOOK22  CCDC88A2  CCDC88C2  HOOK32  CCDC88B2  
    2 SIMAP similar genes for HOOK1 using alignment to 4 protein entries:     HOOK1_HUMAN (see all proteins):
    HOOK3    HOOK2

    HOOK1 for paralogs           About GeneDecksing



    Genomic Variants
    for HOOK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/935 NCBI SNPs in HOOK1 are shown (see all 935)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs74186511,2
    		C,F,A,H,--60278616(+) ACTGAA/C/TGCAGA 1 -- us2k112NS EA NA 1256
    rs1862454841,2
    		--60278617(+) CTGACA/GCAGAA 1 -- us2k10--------
    rs1513369961,2
    		--60278638(+) TCATGG/TGTTTA 1 -- us2k10--------
    rs1901533561,2
    		--60278678(+) TAAAAA/TTTGTT 1 -- us2k10--------
    rs1831510541,2
    		--60278704(+) TGATAA/GTTTAC 1 -- us2k10--------
    rs37542011,2
    		C,F,--60278713(+) ACTCTC/ATATAA 1 -- us2k11Minor allele frequency- A:0.02EA 924
    rs1399224971,2
    		C,--60278741(+) AATTG-/CCCCCC 1 -- us2k10--------
    rs1458690331,2
    		--60278803(+) TGGCTC/TTCAGT 1 -- us2k10--------
    rs1874867691,2
    		--60279108(+) GTCAAC/TAGCAA 1 -- us2k10--------
    rs1455611381,2
    		C,--60279223(+) AATAT-/AAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for HOOK1 (60280458 - 60342050 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HOOK1
         1 CNV: 58399

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    Disorders / Diseases
    for HOOK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOOK1 for disorders           About GeneDecksing

    OMIM gene information: 607820    OMIM disorders: --

    2 diseases for HOOK1:    About MalaCards
    batten disease    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for HOOK1:
    Batten disease
    Human Genome Epidemiology (HuGE) Navigator: HOOK1 (1 document)

    Export disorders for HOOK1 gene to outside databases

    Publications
    for HOOK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOOK1 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with HOOK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic analysis of hook, a gene required for endocytic trafficking in Drosophila. (PubMed id 9927460)1, 2, 3 Kraemer H. and Phistry M. (1999)
    2. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. (PubMed id 18799622)1, 2, 9 Xu L....Harper J.W. (2008)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. (PubMed id 11238449)1, 2 Walenta J.H.... Kraemer H. (2001)
    8. Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway. (PubMed id 15471887)1, 9 Luiro K....Jalanko A. (2004)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    External Searches for HOOK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOOK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51361 HGNC: 19884 AceView: HOOK1 Ensembl:ENSG00000134709 euGenes: HUgn51361
    ECgene: HOOK1 H-InvDB: HOOK1

    Other Databases showing HOOK1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOOK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOOK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOOK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOOK1 gene:
    Search GeneIP for patents involving HOOK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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