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Aliases for HOMEZ Gene

Aliases for HOMEZ Gene

  • Homeobox And Leucine Zipper Encoding 2 3 5
  • KIAA1443 2 3 4
  • Homeodomain Leucine Zipper-Containing Factor 3 4

External Ids for HOMEZ Gene

Previous HGNC Symbols for HOMEZ Gene

  • KIAA1443

Previous GeneCards Identifiers for HOMEZ Gene

  • GC14M022813
  • GC14M023742
  • GC14M003859

Summaries for HOMEZ Gene

GeneCards Summary for HOMEZ Gene

HOMEZ (Homeobox And Leucine Zipper Encoding) is a Protein Coding gene. Diseases associated with HOMEZ include ventricular septal defect. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot for HOMEZ Gene

  • May function as a transcriptional regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMEZ Gene

Genomics for HOMEZ Gene

Regulatory Elements for HOMEZ Gene

Genomic Location for HOMEZ Gene

Chromosome:
14
Start:
23,272,422 bp from pter
End:
23,299,447 bp from pter
Size:
27,026 bases
Orientation:
Minus strand

Genomic View for HOMEZ Gene

Genes around HOMEZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOMEZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOMEZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMEZ Gene

Proteins for HOMEZ Gene

  • Protein details for HOMEZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX15-HOMEZ_HUMAN
    Recommended name:
    Homeobox and leucine zipper protein Homez
    Protein Accession:
    Q8IX15
    Secondary Accessions:
    • A1L445
    • B4DZ80
    • F8WCA3
    • Q6P049
    • Q86XB6
    • Q9P2A5

    Protein attributes for HOMEZ Gene

    Size:
    550 amino acids
    Molecular mass:
    61240 Da
    Quaternary structure:
    • Homodimer or heterodimer (Potential). Interacts with HOXC8.
    SequenceCaution:
    • Sequence=AAN76991.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOMEZ Gene

    Alternative splice isoforms for HOMEZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOMEZ Gene

Proteomics data for HOMEZ Gene at MOPED

Post-translational modifications for HOMEZ Gene

  • Ubiquitination at Lys 230
  • Modification sites at PhosphoSitePlus

Other Protein References for HOMEZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOMEZ Gene

Domains & Families for HOMEZ Gene

Gene Families for HOMEZ Gene

Protein Domains for HOMEZ Gene

Suggested Antigen Peptide Sequences for HOMEZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IX15

UniProtKB/Swiss-Prot:

HOMEZ_HUMAN :
  • Contains 3 homeobox DNA-binding domains.
Domain:
  • Contains 3 homeobox DNA-binding domains.
genes like me logo Genes that share domains with HOMEZ: view

Function for HOMEZ Gene

Molecular function for HOMEZ Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional regulator.

Gene Ontology (GO) - Molecular Function for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HOMEZ: view
genes like me logo Genes that share phenotypes with HOMEZ: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HOMEZ Gene

Localization for HOMEZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMEZ Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOMEZ Gene COMPARTMENTS Subcellular localization image for HOMEZ gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for HOMEZ Gene

Pathways & Interactions for HOMEZ Gene

SuperPathways for HOMEZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOMEZ Gene

None

No data available for Pathways by source and SIGNOR curated interactions for HOMEZ Gene

Drugs & Compounds for HOMEZ Gene

(1) Drugs for HOMEZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HOMEZ: view

Transcripts for HOMEZ Gene

Unigene Clusters for HOMEZ Gene

Homeobox and leucine zipper encoding:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOMEZ Gene

No ASD Table

Relevant External Links for HOMEZ Gene

GeneLoc Exon Structure for
HOMEZ
ECgene alternative splicing isoforms for
HOMEZ

Expression for HOMEZ Gene

mRNA expression in normal human tissues for HOMEZ Gene

Protein differential expression in normal tissues from HIPED for HOMEZ Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOMEZ Gene



SOURCE GeneReport for Unigene cluster for HOMEZ Gene Hs.632332

mRNA Expression by UniProt/SwissProt for HOMEZ Gene

Q8IX15-HOMEZ_HUMAN
Tissue specificity: Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.
genes like me logo Genes that share expression patterns with HOMEZ: view

Protein tissue co-expression partners for HOMEZ Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HOMEZ Gene

Orthologs for HOMEZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOMEZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOMEZ 35
  • 90.18 (n)
  • 87.8 (a)
KIAA1443 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOMEZ 35
  • 90.88 (n)
  • 87.99 (a)
HOMEZ 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Homez 35
  • 80.21 (n)
  • 77.71 (a)
Homez 16
Homez 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOMEZ 35
  • 98.93 (n)
  • 98.6 (a)
HOMEZ 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Homez 35
  • 81.6 (n)
  • 79.23 (a)
oppossum
(Monodelphis domestica)
Mammalia HOMEZ 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOMEZ 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOMEZ 36
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii homez 36
  • 18 (a)
OneToMany
HOMEZ (1 of 2) 36
  • 14 (a)
OneToMany
Species with no ortholog for HOMEZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMEZ Gene

ENSEMBL:
Gene Tree for HOMEZ (if available)
TreeFam:
Gene Tree for HOMEZ (if available)

Paralogs for HOMEZ Gene

Paralogs for HOMEZ Gene

genes like me logo Genes that share paralogs with HOMEZ: view

Variants for HOMEZ Gene

Sequence variations from dbSNP and Humsavar for HOMEZ Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10131813 - 23,276,324(+) AGAGG(C/G/T)GGCAG reference, missense
rs1055061 -- 23,275,723(-) CTCTC(A/G)ATTAC reference, missense
rs1057119 -- 23,277,060(+) GCTTG(C/G/T)GTCCA reference, synonymous-codon
rs2295124 -- 23,286,389(+) TTGGA(A/G)TACAC upstream-variant-2KB
rs2295125 -- 23,286,398(+) ACCGG(A/C/G)CCAGG upstream-variant-2KB

Variation tolerance for HOMEZ Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.30; 96.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOMEZ Gene

HapMap Linkage Disequilibrium report
HOMEZ
Human Gene Mutation Database (HGMD)
HOMEZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HOMEZ Gene

Disorders for HOMEZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOMEZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ventricular septal defect
  • interventricular septal defect
- elite association - COSMIC cancer census association via MalaCards
Search HOMEZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOMEZ

Human Genome Epidemiology (HuGE) Navigator
HOMEZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOMEZ
genes like me logo Genes that share disorders with HOMEZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOMEZ Gene

Publications for HOMEZ Gene

  1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D. … Ruddle F.H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Identification of two novel mutations of the HOMEZ gene in Chinese patients with isolated ventricular septal defect. (PMID: 23574532) Xuan C. … He G.W. (Genet Test Mol Biomarkers 2013) 3

Products for HOMEZ Gene

Sources for HOMEZ Gene

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