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Aliases for HOMEZ Gene

Aliases for HOMEZ Gene

  • Homeobox And Leucine Zipper Encoding 2 3
  • KIAA1443 2 3 4
  • Homeodomain Leucine Zipper-Containing Factor 3 4

External Ids for HOMEZ Gene

Previous HGNC Symbols for HOMEZ Gene

  • KIAA1443

Previous GeneCards Identifiers for HOMEZ Gene

  • GC14M022813
  • GC14M023742
  • GC14M003859

Summaries for HOMEZ Gene

GeneCards Summary for HOMEZ Gene

HOMEZ (Homeobox And Leucine Zipper Encoding) is a Protein Coding gene. Diseases associated with HOMEZ include ventricular septal defect. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot for HOMEZ Gene

  • May function as a transcriptional regulator

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMEZ Gene

Genomics for HOMEZ Gene

Regulatory Elements for HOMEZ Gene

Genomic Location for HOMEZ Gene

23,272,422 bp from pter
23,299,447 bp from pter
27,026 bases
Minus strand

Genomic View for HOMEZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for HOMEZ Gene

Proteins for HOMEZ Gene

  • Protein details for HOMEZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox and leucine zipper protein Homez
    Protein Accession:
    Secondary Accessions:
    • A1L445
    • B4DZ80
    • F8WCA3
    • Q6P049
    • Q86XB6
    • Q9P2A5

    Protein attributes for HOMEZ Gene

    550 amino acids
    Molecular mass:
    61240 Da
    Quaternary structure:
    • Homodimer or heterodimer (Potential). Interacts with HOXC8.
    • Sequence=AAN76991.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOMEZ Gene

    Alternative splice isoforms for HOMEZ Gene


neXtProt entry for HOMEZ Gene

Proteomics data for HOMEZ Gene at MOPED

Post-translational modifications for HOMEZ Gene

  • Ubiquitination at Lys 230
  • Modification sites at PhosphoSitePlus

Other Protein References for HOMEZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOMEZ Gene

Domains & Families for HOMEZ Gene

Gene Families for HOMEZ Gene

Protein Domains for HOMEZ Gene

Suggested Antigen Peptide Sequences for HOMEZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 homeobox DNA-binding domains.
  • Contains 3 homeobox DNA-binding domains.
genes like me logo Genes that share domains with HOMEZ: view

Function for HOMEZ Gene

Molecular function for HOMEZ Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional regulator

Gene Ontology (GO) - Molecular Function for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HOMEZ: view

Phenotypes for HOMEZ Gene

genes like me logo Genes that share phenotypes with HOMEZ: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HOMEZ Gene

Localization for HOMEZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMEZ Gene

Subcellular locations from

Jensen Localization Image for HOMEZ Gene COMPARTMENTS Subcellular localization image for HOMEZ gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOMEZ: view

Pathways & Interactions for HOMEZ Gene

SuperPathways for HOMEZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with HOMEZ: view

No data available for Pathways by source and SIGNOR curated interactions for HOMEZ Gene

Drugs & Compounds for HOMEZ Gene

(1) Drugs for HOMEZ Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
leucine Nutra 93
genes like me logo Genes that share compounds with HOMEZ: view

Transcripts for HOMEZ Gene

Unigene Clusters for HOMEZ Gene

Homeobox and leucine zipper encoding:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOMEZ

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOMEZ Gene

No ASD Table

Relevant External Links for HOMEZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOMEZ Gene

mRNA expression in normal human tissues for HOMEZ Gene

Protein differential expression in normal tissues from HIPED for HOMEZ Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOMEZ Gene

SOURCE GeneReport for Unigene cluster for HOMEZ Gene Hs.632332

mRNA Expression by UniProt/SwissProt for HOMEZ Gene

Tissue specificity: Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.
genes like me logo Genes that share expression patterns with HOMEZ: view

Protein tissue co-expression partners for HOMEZ Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HOMEZ Gene

Orthologs for HOMEZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOMEZ Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HOMEZ 35
  • 90.18 (n)
  • 87.8 (a)
KIAA1443 36
  • 87 (a)
(Canis familiaris)
Mammalia HOMEZ 35
  • 90.88 (n)
  • 87.99 (a)
  • 84 (a)
(Mus musculus)
Mammalia Homez 35
  • 80.21 (n)
  • 77.71 (a)
Homez 16
Homez 36
  • 78 (a)
(Pan troglodytes)
Mammalia HOMEZ 35
  • 98.93 (n)
  • 98.6 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Homez 35
  • 81.6 (n)
  • 79.23 (a)
(Monodelphis domestica)
Mammalia HOMEZ 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia HOMEZ 36
  • 59 (a)
(Anolis carolinensis)
Reptilia HOMEZ 36
  • 48 (a)
(Danio rerio)
Actinopterygii homez 36
  • 18 (a)
HOMEZ (1 of 2) 36
  • 14 (a)
Species with no ortholog for HOMEZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMEZ Gene

Gene Tree for HOMEZ (if available)
Gene Tree for HOMEZ (if available)

Paralogs for HOMEZ Gene

Paralogs for HOMEZ Gene

genes like me logo Genes that share paralogs with HOMEZ: view

Variants for HOMEZ Gene

Sequence variations from dbSNP and Humsavar for HOMEZ Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1055061 -- 23,275,723(-) CTCTC(A/G)ATTAC missense, reference
rs1057119 -- 23,277,060(+) GCTTG(C/G/T)GTCCA synonymous-codon, reference
rs2295124 -- 23,286,389(+) TTGGA(A/G)TACAC upstream-variant-2KB
rs2295125 -- 23,286,398(+) ACCGG(A/C/G)CCAGG upstream-variant-2KB
rs3208861 -- 23,275,614(-) GAAGA(A/G/T)GATGA missense, reference

Variation tolerance for HOMEZ Gene

Residual Variation Intolerance Score: 52.61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.30; 96.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOMEZ Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HOMEZ Gene

Disorders for HOMEZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOMEZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ventricular septal defect
  • interventricular septal defect
- elite association
Search HOMEZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOMEZ

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HOMEZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOMEZ Gene

Publications for HOMEZ Gene

  1. Homeodomain-leucine zipper proteins interact with a plant homologue of the transcriptional co-activator multiprotein bridging factor 1. (PMID: 15469713) Zanetti M.E. … CasalonguAc C.A. (J. Biochem. Mol. Biol. 2004) 23 67
  2. Engineering the loop region of a homeodomain-leucine zipper protein promotes efficient binding to a monomeric DNA binding site. (PMID: 15595839) Tron A.E. … Gonzalez D.H. (Biochemistry 2004) 23 67
  3. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D. … Ruddle F.H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 67
  4. Positively charged residues at the N-terminal arm of the homeodomain are required for efficient DNA binding by homeodomain-leucine zipper proteins. (PMID: 11302705) Palena C.M. … Chan R.L. (J. Mol. Biol. 2001) 23 67
  5. IFL1, a gene regulating interfascicular fiber differentiation in Arabidopsis, encodes a homeodomain-leucine zipper protein. (PMID: 10559440) Zhong R. … Ye Z.H. (Plant Cell 1999) 23 67

Products for HOMEZ Gene

Sources for HOMEZ Gene

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