HOMEZ Gene
protein-coding GIFtS: 44
GCID: GC14M023742
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homeobox and leucine zipper encoding(Previous name: KIAA1443 )
(Previous symbol: KIAA1443)
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Aliases
for HOMEZ gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Homeobox And Leucine Zipper Encoding1 2 | | KIAA14431 2 3 | | Homeodomain Leucine Zipper-Containing Factor2 3 | | Homeobox And Leucine Zipper Protein Homez2 |
Export aliases for HOMEZ gene to outside databasesPrevious GC identifers: GC14M022813 GC14M003859 |
Summaries
for HOMEZ gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: HOMEZ_HUMAN, Q8IX15Function: May function as a transcriptional regulator
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Genomic Views
for HOMEZ gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the HOMEZ gene promoter:
AREB6 STAT1 Sp1 Lmo2 CUTL1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for HOMEZ
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOMEZ |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q11.2 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2HOMEZ Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M023742: view genomic region
(about GC identifiers)
Start:
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23,742,844 bp from pter |
End:
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23,755,326 bp from pter |
Size:
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12,483 bases |
Orientation:
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minus strand |
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Proteins
for HOMEZ gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: HOMEZ_HUMAN, Q8IX15 (See
protein sequence)Recommended Name: Homeobox and leucine zipper protein Homez Size: 550 amino acids; 61240 Da
Subunit: Homodimer or heterodimer (Potential). Interacts with HOXC8
Subcellular location: Nucleus
Caution: It is uncertain whether Met-1 or Met-25 is the initiator
Sequence caution: Sequence=AAN76991.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAA92681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
2 PDB 3D structures from  and Proteopedia  for HOMEZ:2ECC (3D)
2YS9 (3D)
Secondary accessions: A1L445 Q6P049 Q86XB6 Q9P2A5Explore the universe of human proteins at neXtProt for HOMEZ: NX_Q8IX15
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IX15
HOMEZ Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065885.2
ENSEMBL proteins: ENSP00000350049
Human Recombinant Protein Products for HOMEZ:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
HOMEZ for ontologies About GeneDecksing
HOMEZ Antibody Products:
Assay Products for HOMEZ: |
Protein
Domains /
Families
for HOMEZ gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
HOMEZ for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IX15ProtoNet protein and cluster: Q8IX15 UniProtKB/Swiss-Prot: HOMEZ_HUMAN, Q8IX15Similarity: Contains 2 homeobox DNA-binding domains |
Function
for HOMEZ gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: HOMEZ_HUMAN, Q8IX15Function: May function as a transcriptional regulator Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
HOMEZ for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOMEZ (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOMEZ (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: HOMEZ (NM_020834) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HOMEZ | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOMEZ |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMEZ |
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Pathways & Interactions
for HOMEZ gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HOMEZ
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for HOMEZ (Q8IX153 ENSP000003500494) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- |
HOMEZ for ontologies About GeneDecksing
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Drugs & Compounds
for HOMEZ gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
HOMEZ for compounds About GeneDecksing
 Browse Tocris compounds for HOMEZ
1 Novoseek chemical compound relationship for HOMEZ gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leucine |
55.7 |
5 |
11302705 (3), 15595839 (1), 15469713 (1) |
Search CenterWatch for drugs/clinical trials and news about HOMEZ
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Transcripts
for HOMEZ gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for HOMEZ gene: NM_020834.2 Unigene Cluster for HOMEZ: Homeobox and leucine zipper encoding Hs.632332 [show with all ESTs]Unigene Representative Sequence: NM_0208343 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357460(uc001wja.2 uc001wjb.2) ENST00000561396 ENST00000558278
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOMEZ (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOMEZ (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: HOMEZ (NM_020834) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for HOMEZ | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOMEZ |
Additional cDNA sequence: AB037864.1 AF463523.1 AK296927.1 AK301849.1 AK302788.1 BC045733.1 BC130392.1 9 DOTS entries: DT.443680 DT.91871587 DT.92423077 DT.100020798 DT.65285354 DT.436898 DT.120748362 DT.65285353 DT.99976616 24/203 AceView cDNA sequences (see all 203): AI349507 BU686902 AK024489 AI075115 AI128336 CA394118 BQ064437 AK091943 AI567522 BQ427742 CR598790 CB049542 AF463523 AI685035 AW449317 BU845075 AI023932 BE264625 BX379400 R73365 BX248758 CR619320 BG562791 AI264023
GeneLoc Exon Structure
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Expression
for HOMEZ gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| HOMEZ expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCAACTAAA
About this image
See HOMEZ Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HOMEZ
SOURCE GeneReport for Unigene cluster: Hs.632332
UniProtKB/Swiss-Prot: HOMEZ_HUMAN, Q8IX15Tissue specificity: Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney
SABiosciences Custom PCR Arrays for HOMEZ
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOMEZ
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat HOMEZ | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOMEZ | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOMEZ | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMEZ |
Orthologs
for HOMEZ gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for HOMEZ gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for HOMEZ (if available)
TreeFam Gene Tree for HOMEZ (if available) |
Paralogs
for HOMEZ gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for HOMEZ gene
- ENSG000002601752 ZHX22 ZHX32 ZHX12
HOMEZ for paralogs About GeneDecksing
|
Genomic Variants
for HOMEZ gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for HOMEZ (23742844 - 23755326 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HOMEZ: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOMEZ |
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Disorders
/ Diseases
for HOMEZ gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 HOMEZ for disorders About MalaCards
HOMEZ for disorders About GeneDecksing
OMIM gene information: 608119
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: HOMEZ (1 document)
Export disorders for HOMEZ gene to outside databases
|
Publications
for HOMEZ gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for HOMEZ gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with HOMEZ) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PubMed id 12925734)1, 2, 3 Bayarsaihan D.... Ruddle F.H. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Consanguinity mapping of congenital heart disease in a South Indian population. (PubMed id 20422016)1 McGregor T.L....Morgan T.M. (2010)
- System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1 Beausoleil S.A....Gygi S.P. (2004)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (2003)
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External Searches for HOMEZ gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing HOMEZ gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing HOMEZ gene
(According to HUGE)
About This Section
| |
Specialized Databases showing HOMEZ gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for HOMEZ | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for HOMEZ gene:
Search GeneIP for patents involving HOMEZ
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for HOMEZ gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for HOMEZ | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOMEZ | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for HOMEZ | | | OriGene Protein Over-expression Lysate for HOMEZ | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for HOMEZ | | OriGene 3'-UTR Clone for HOMEZ | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOMEZ | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOMEZ | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for HOMEZ | | OriGene Custom Protein Services for HOMEZ | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat HOMEZ | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HOMEZ | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOMEZ | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HOMEZ | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOMEZ | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HOMEZ |
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 | | | HOMEZ Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMEZ |
|  |  |  |  | | | | ThermoFisher Antibodies for HOMEZ |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOMEZ |
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