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Aliases for HOMEZ Gene

Aliases for HOMEZ Gene

  • Homeobox And Leucine Zipper Encoding 2 3
  • KIAA1443 2 3 4
  • Homeodomain Leucine Zipper-Containing Factor 3 4
  • Homeobox And Leucine Zipper Protein Homez 3

External Ids for HOMEZ Gene

Previous HGNC Symbols for HOMEZ Gene

  • KIAA1443

Previous GeneCards Identifiers for HOMEZ Gene

  • GC14M022813
  • GC14M023742
  • GC14M003859

Summaries for HOMEZ Gene

GeneCards Summary for HOMEZ Gene

HOMEZ (Homeobox And Leucine Zipper Encoding) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot for HOMEZ Gene

  • May function as a transcriptional regulator

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMEZ Gene

Genomics for HOMEZ Gene

Regulatory Elements for HOMEZ Gene

Genomic Location for HOMEZ Gene

23,272,422 bp from pter
23,299,447 bp from pter
27,026 bases
Minus strand

Genomic View for HOMEZ Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOMEZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMEZ Gene

Proteins for HOMEZ Gene

  • Protein details for HOMEZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox and leucine zipper protein Homez
    Protein Accession:
    Secondary Accessions:
    • A1L445
    • B4DZ80
    • F8WCA3
    • Q6P049
    • Q86XB6
    • Q9P2A5

    Protein attributes for HOMEZ Gene

    550 amino acids
    Molecular mass:
    61240 Da
    Quaternary structure:
    • Homodimer or heterodimer (Potential). Interacts with HOXC8.
    • Sequence=AAN76991.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOMEZ Gene

    Alternative splice isoforms for HOMEZ Gene


neXtProt entry for HOMEZ Gene

Proteomics data for HOMEZ Gene at MOPED

Post-translational modifications for HOMEZ Gene

  • Ubiquitination at Lys230
  • Modification sites at PhosphoSitePlus

Other Protein References for HOMEZ Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOMEZ Gene

Domains for HOMEZ Gene

Gene Families for HOMEZ Gene

Protein Domains for HOMEZ Gene

Suggested Antigen Peptide Sequences for HOMEZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 homeobox DNA-binding domains.
  • Contains 2 homeobox DNA-binding domains.
genes like me logo Genes that share domains with HOMEZ: view

Function for HOMEZ Gene

Molecular function for HOMEZ Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional regulator

Gene Ontology (GO) - Molecular Function for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity IBA --
GO:0003714 transcription corepressor activity IBA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with HOMEZ: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HOMEZ Gene

Localization for HOMEZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMEZ Gene

Subcellular locations from

Jensen Localization Image for HOMEZ Gene COMPARTMENTS Subcellular localization image for HOMEZ gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOMEZ: view

Pathways for HOMEZ Gene

SuperPathways for HOMEZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with HOMEZ: view

No data available for Pathways by source for HOMEZ Gene

Drugs for HOMEZ Gene

(1) Novoseek inferred chemical compound relationships for HOMEZ Gene

Compound -log(P) Hits PubMed IDs
leucine 55.7 5
genes like me logo Genes that share compounds with HOMEZ: view

Transcripts for HOMEZ Gene

Unigene Clusters for HOMEZ Gene

Homeobox and leucine zipper encoding:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOMEZ

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOMEZ Gene

No ASD Table

Relevant External Links for HOMEZ Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOMEZ Gene

mRNA expression in normal human tissues for HOMEZ Gene

Protein differential expression in normal tissues for HOMEZ Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOMEZ Gene

SOURCE GeneReport for Unigene cluster for HOMEZ Gene Hs.632332

mRNA Expression by UniProt/SwissProt for HOMEZ Gene

Tissue specificity: Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.
genes like me logo Genes that share expressions with HOMEZ: view

Expression partners for HOMEZ Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HOMEZ Gene

Orthologs for HOMEZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOMEZ Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HOMEZ 35
  • 90.18 (n)
  • 87.8 (a)
KIAA1443 36
  • 87 (a)
(Canis familiaris)
Mammalia HOMEZ 35
  • 90.88 (n)
  • 87.99 (a)
  • 84 (a)
(Mus musculus)
Mammalia Homez 35
  • 80.21 (n)
  • 77.71 (a)
Homez 16
Homez 36
  • 78 (a)
(Pan troglodytes)
Mammalia HOMEZ 35
  • 98.93 (n)
  • 98.6 (a)
  • 96 (a)
(Rattus norvegicus)
Mammalia Homez 35
  • 81.6 (n)
  • 79.23 (a)
(Monodelphis domestica)
Mammalia HOMEZ 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia HOMEZ 36
  • 59 (a)
(Anolis carolinensis)
Reptilia HOMEZ 36
  • 48 (a)
(Danio rerio)
Actinopterygii homez 36
  • 18 (a)
HOMEZ (1 of 2) 36
  • 14 (a)
Species with no ortholog for HOMEZ:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMEZ Gene

Gene Tree for HOMEZ (if available)
Gene Tree for HOMEZ (if available)

Paralogs for HOMEZ Gene

Paralogs for HOMEZ Gene

genes like me logo Genes that share paralogs with HOMEZ: view

Variants for HOMEZ Gene

Sequence variations from dbSNP and Humsavar for HOMEZ Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1055061 -- 23,275,723(-) CTCTC(A/G)ATTAC missense, reference
rs1057119 -- 23,277,060(+) GCTTG(C/G)GTCCA synonymous-codon, reference
rs2295124 -- 23,286,389(+) TTGGA(A/G)TACAC upstream-variant-2KB
rs2295125 -- 23,286,398(+) ACCGG(A/C/G)CCAGG upstream-variant-2KB
rs3208861 -- 23,275,614(-) GAAGA(A/G/T)GATGA missense, reference

Relevant External Links for HOMEZ Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for HOMEZ Gene

Disorders for HOMEZ Gene

Relevant External Links for HOMEZ

Human Genome Epidemiology (HuGE) Navigator

No disorders were found for HOMEZ Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for HOMEZ Gene

Publications for HOMEZ Gene

  1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D. … Ruddle F.H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for HOMEZ Gene

Sources for HOMEZ Gene

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