Aliases for HOMEZ Gene
Aliases for HOMEZ Gene
External Ids for HOMEZ Gene
- HGNC: 20164
- Entrez Gene: 57594
- Ensembl: ENSG00000215271
- OMIM: 608119
- UniProtKB: Q8IX15
Previous HGNC Symbols for HOMEZ Gene
- KIAA1443
Previous GeneCards Identifiers for HOMEZ Gene
- GC14M022813
- GC14M023742
- GC14M003859
Summaries for HOMEZ Gene
GeneCards Summary for HOMEZ Gene
HOMEZ (Homeobox And Leucine Zipper Encoding) is a Protein Coding gene. Diseases associated with HOMEZ include Ventricular Septal Defect. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ZHX1.
UniProtKB/Swiss-Prot for HOMEZ Gene
-
May function as a transcriptional regulator.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMEZ Gene
Genomics for HOMEZ Gene
Regulatory Elements for HOMEZ Gene
Enhancers for HOMEZ Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOMEZ on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOMEZ gene promoter:
Regulatory Element Products
Genomic Location for HOMEZ Gene
- Chromosome:
- 14
- Start:
- 23,272,422 bp from pter
- End:
- 23,299,447 bp from pter
- Size:
- 27,026 bases
- Orientation:
- Minus strand
Genomic View for HOMEZ Gene
Genes around HOMEZ on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q11.2 by Ensembl
- 14q11.2 by Entrez Gene
- 14q11.2 by HGNC
HOMEZ Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOMEZ Gene
Proteins for HOMEZ Gene
-
Protein details for HOMEZ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IX15-HOMEZ_HUMAN
- Recommended name:
- Homeobox and leucine zipper protein Homez
- Protein Accession:
- Q8IX15
- A1L445
- B4DZ80
- F8WCA3
- Q6P049
- Q86XB6
- Q9P2A5
Protein attributes for HOMEZ Gene
- Size:
- 550 amino acids
- Molecular mass:
- 61240 Da
- Quaternary structure:
-
- Homodimer or heterodimer (Potential). Interacts with HOXC8.
- SequenceCaution:
-
- Sequence=AAN76991.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for HOMEZ Gene
Post-translational modifications for HOMEZ Gene
Other Protein References for HOMEZ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOMEZ
- Invitrogen Antibodies for HOMEZ
- antibodies-online Antibodies for HOMEZ: See all 36
- GeneTex HOMEZ antibody for HOMEZ
Protein Products
-
OriGene Purified Proteins for HOMEZ
- Search Origene for MassSpec and Protein Over-expression Lysates for HOMEZ
- Origene Custom Protein Services for HOMEZ
- Search GeneTex for Proteins for HOMEZ
Assay Products
No data available for DME Specific Peptides for HOMEZ Gene
Domains & Families for HOMEZ Gene
Gene Families for HOMEZ Gene
Protein Domains for HOMEZ Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOMEZ Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for HOMEZ Gene
Function for HOMEZ Gene
Molecular function for HOMEZ Gene
- UniProtKB/Swiss-Prot Function:
- May function as a transcriptional regulator.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IBA | -- |
| GO:0003714 | transcription corepressor activity | IBA | -- |
Phenotypes for HOMEZ Gene
- MGI mutant phenotypes for HOMEZ:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOMEZ:
Animal Models for HOMEZ Gene
- MGI Knock Outs for HOMEZ:
-
- Homez tm1e(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOMEZ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOMEZ gene
- Search ViGene Biosciences for HOMEZ
CRISPR Products
-
OriGene CRISPR knockouts for HOMEZ
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOMEZ
- GenScript: Design CRISPR guide RNA sequences for HOMEZ
miRNA for HOMEZ Gene
- miRTarBase miRNAs that target HOMEZ
miRNA Products
- Search ViGene Biosciences for HOMEZ
Inhibitory RNA Products
- Origene siRNA, RNAi, and shRNA products in human, mouse, rat for HOMEZ
- Browse OriGene Inhibitory RNA Products For HOMEZ
-
ViGene Biosciences ready-to-package AAV shRNAs for HOMEZ gene
Clone Products
-
OriGene ORF clones in human for HOMEZ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOMEZ
Cell Line Products
-
Horizon Cell Lines for HOMEZ
-
ViGene Biosciences adenoviral particle packaged cDNA for HOMEZ gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOMEZ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOMEZ gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOMEZ Gene
Localization for HOMEZ Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOMEZ Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for HOMEZ Gene
No Data Available
Interacting Proteins for HOMEZ Gene
Selected Interacting proteins:
ENSP00000350049
Q8IX15-HOMEZ_HUMAN
for HOMEZ Gene via
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IBA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for HOMEZ Gene
Transcripts for HOMEZ Gene
mRNA/cDNA for HOMEZ Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (203) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HOMEZ Gene
CRISPR Products
-
OriGene CRISPR knockouts for HOMEZ
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOMEZ
- GenScript: Design CRISPR guide RNA sequences for HOMEZ
miRNA Products
- Search ViGene Biosciences for HOMEZ
Inhibitory RNA Products
- Origene siRNA, RNAi, and shRNA products in human, mouse, rat for HOMEZ
- Browse OriGene Inhibitory RNA Products For HOMEZ
-
ViGene Biosciences ready-to-package AAV shRNAs for HOMEZ gene
Clone Products
-
OriGene ORF clones in human for HOMEZ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for HOMEZ
Flow Cytometry Products
Expression for HOMEZ Gene
This gene is overexpressed in Testis (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOMEZ Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of HOMEZ Gene:
HOMEZSOURCE GeneReport for Unigene cluster for HOMEZ Gene:
Hs.632332mRNA Expression by UniProt/SwissProt for HOMEZ Gene:
Q8IX15-HOMEZ_HUMAN
Tissue specificity:
Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.
Evidence on tissue expression from TISSUES for HOMEZ Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for HOMEZ
-
OriGene qPCR primer pairs and template standards for HOMEZ
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOMEZ Gene
Orthologs for HOMEZ Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOMEZ 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOMEZ 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOMEZ 34 |
|
||
| KIAA1443 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Homez 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Homez 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOMEZ 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOMEZ 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | HOMEZ 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | homez 35 |
|
OneToMany | |
| HOMEZ (1 of 2) 35 |
|
OneToMany |
- Species where no ortholog for HOMEZ was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOMEZ Gene
Variants for HOMEZ Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000044977 | -- | 23,274,675(+) | GGCCA(A/C)GGTGG | downstream-variant-500B, utr-variant-3-prime | |
| rs1000078309 | -- | 23,282,744(+) | TACTT(C/T)CGTTT | intron-variant | |
| rs1000168744 | -- | 23,273,942(+) | TCAAT(A/G)AGTCC | downstream-variant-500B, utr-variant-3-prime | |
| rs1000323310 | -- | 23,280,082(+) | TTCTT(A/G)GTGGT | intron-variant | |
| rs1000342342 | -- | 23,285,979(+) | GAGGG(C/G)AGGGG | utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2763062 | CNV | gain | 21179565 |
Residual Variation Intolerance Score:
52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
14.30;
96.29% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOMEZ Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOMEZ Gene
Disorders for HOMEZ Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ventricular septal defect |
|
|
Search HOMEZ in MalaCards
View complete list of genes associated with diseases
Relevant External Links for HOMEZ
No data available for UniProtKB/Swiss-Prot and Genatlas for HOMEZ Gene
Publications for HOMEZ Gene
- Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D. … Ruddle F.H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for HOMEZ Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HOMEZ
- Search Origene for MassSpec and Protein Over-expression Lysates for HOMEZ
- Origene Custom Protein Services for HOMEZ
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOMEZ
- Browse OriGene Inhibitory RNA Products For HOMEZ
- OriGene qPCR primer pairs and template standards for HOMEZ
- OriGene qPCR primer pairs for HOMEZ
- OriGene CRISPR knockouts for HOMEZ
- OriGene ORF clones in human for HOMEZ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HOMEZ
- GenScript: Next-day shipping cDNA ORF clone for HOMEZ in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HOMEZ
- GenScript Custom Assay Services for HOMEZ
- GenScript Custom overexpressing Cell Line Services for HOMEZ
- GenScript: Design CRISPR guide RNA sequences for HOMEZ
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HOMEZ
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HOMEZ
- Novus Biologicals proteins and lysates for HOMEZ
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for HOMEZ gene
- ViGene Biosciences lentiviral particle packaged cDNA for HOMEZ gene
- ViGene Biosciences ready-to-package AAV shRNAs for HOMEZ gene
- Search ViGene Biosciences for HOMEZ
- Horizon Cell Lines for HOMEZ
- Cyagen custom Knockout/knockin (KOKI) mouse models for HOMEZ
- VectorBuilder custom plasmid, inducible vectors for HOMEZ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOMEZ
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOMEZ Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer