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Aliases for HOMEZ Gene

Aliases for HOMEZ Gene

  • Homeobox And Leucine Zipper Encoding 2 3 5
  • KIAA1443 2 3 4
  • Homeodomain Leucine Zipper-Containing Factor 3 4
  • Homeobox And Leucine Zipper Protein Homez 3

External Ids for HOMEZ Gene

Previous HGNC Symbols for HOMEZ Gene

  • KIAA1443

Previous GeneCards Identifiers for HOMEZ Gene

  • GC14M022813
  • GC14M023742
  • GC14M003859

Summaries for HOMEZ Gene

GeneCards Summary for HOMEZ Gene

HOMEZ (Homeobox And Leucine Zipper Encoding) is a Protein Coding gene. Diseases associated with HOMEZ include Ventricular Septal Defect. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ZHX1.

UniProtKB/Swiss-Prot for HOMEZ Gene

  • May function as a transcriptional regulator.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMEZ Gene

Genomics for HOMEZ Gene

Regulatory Elements for HOMEZ Gene

Enhancers for HOMEZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022504 1.9 FANTOM5 Ensembl ENCODE 23.1 +761.3 761260 66.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 MMP14 ABHD4 OXA1L LOC105370399 EFS HOMEZ C14orf119 DAD1 ENSG00000258457 TRAV37
GH14F024113 1.2 ENCODE 31.5 -815.4 -815394 3.1 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 RNA5SP383 KHNYN HOMEZ LOC102724814 NFATC4 CIDEB EMC9 NOP9 PSME1 PCK2
GH14F024091 1.4 Ensembl ENCODE 23.7 -794.2 -794200 6.5 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RNA5SP383 KHNYN HOMEZ C14orf119 LOC102724814 CARMIL3 NYNRIN DCAF11 NRL TM9SF1
GH14F023297 1.2 ENCODE 24.5 -1.3 -1253 5.5 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 HOMEZ RNA5SP383 LOC102724814 MMP14 ABHD4 BCL2L2-PABPN1 EFS C14orf119 ENSG00000258457 NOP9
GH14F024212 1.2 ENCODE 24.3 -915.2 -915241 4.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 HOMEZ MDP1 KHNYN CMA1 PABPN1 RNA5SP383 CTSG CIDEB LOC102724814 NFATC4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOMEZ on UCSC Golden Path with GeneCards custom track

Genomic Location for HOMEZ Gene

Chromosome:
14
Start:
23,272,422 bp from pter
End:
23,299,447 bp from pter
Size:
27,026 bases
Orientation:
Minus strand

Genomic View for HOMEZ Gene

Genes around HOMEZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOMEZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOMEZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMEZ Gene

Proteins for HOMEZ Gene

  • Protein details for HOMEZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IX15-HOMEZ_HUMAN
    Recommended name:
    Homeobox and leucine zipper protein Homez
    Protein Accession:
    Q8IX15
    Secondary Accessions:
    • A1L445
    • B4DZ80
    • F8WCA3
    • Q6P049
    • Q86XB6
    • Q9P2A5

    Protein attributes for HOMEZ Gene

    Size:
    550 amino acids
    Molecular mass:
    61240 Da
    Quaternary structure:
    • Homodimer or heterodimer (Potential). Interacts with HOXC8.
    SequenceCaution:
    • Sequence=AAN76991.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA92681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOMEZ Gene

    Alternative splice isoforms for HOMEZ Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOMEZ Gene

Post-translational modifications for HOMEZ Gene

  • Ubiquitination at Lys 230
  • Modification sites at PhosphoSitePlus

Other Protein References for HOMEZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOMEZ Gene

Domains & Families for HOMEZ Gene

Gene Families for HOMEZ Gene

Protein Domains for HOMEZ Gene

Suggested Antigen Peptide Sequences for HOMEZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IX15

UniProtKB/Swiss-Prot:

HOMEZ_HUMAN :
  • Contains 3 homeobox DNA-binding domains.
Domain:
  • Contains 3 homeobox DNA-binding domains.
genes like me logo Genes that share domains with HOMEZ: view

Function for HOMEZ Gene

Molecular function for HOMEZ Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional regulator.

Gene Ontology (GO) - Molecular Function for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IBA --
GO:0003714 transcription corepressor activity IBA --
genes like me logo Genes that share ontologies with HOMEZ: view
genes like me logo Genes that share phenotypes with HOMEZ: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HOMEZ Gene

Localization for HOMEZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMEZ Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOMEZ gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOMEZ: view

Pathways & Interactions for HOMEZ Gene

SuperPathways for HOMEZ Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOMEZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with HOMEZ: view

No data available for Pathways by source and SIGNOR curated interactions for HOMEZ Gene

Drugs & Compounds for HOMEZ Gene

(1) Drugs for HOMEZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HOMEZ: view

Transcripts for HOMEZ Gene

Unigene Clusters for HOMEZ Gene

Homeobox and leucine zipper encoding:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOMEZ Gene

No ASD Table

Relevant External Links for HOMEZ Gene

GeneLoc Exon Structure for
HOMEZ
ECgene alternative splicing isoforms for
HOMEZ

Expression for HOMEZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for HOMEZ Gene

Protein differential expression in normal tissues from HIPED for HOMEZ Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOMEZ Gene



Protein tissue co-expression partners for HOMEZ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HOMEZ Gene:

HOMEZ

SOURCE GeneReport for Unigene cluster for HOMEZ Gene:

Hs.632332

mRNA Expression by UniProt/SwissProt for HOMEZ Gene:

Q8IX15-HOMEZ_HUMAN
Tissue specificity: Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.
genes like me logo Genes that share expression patterns with HOMEZ: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for HOMEZ Gene

Orthologs for HOMEZ Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOMEZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOMEZ 34 35
  • 98.93 (n)
dog
(Canis familiaris)
Mammalia HOMEZ 34 35
  • 90.88 (n)
cow
(Bos Taurus)
Mammalia HOMEZ 34
  • 90.18 (n)
KIAA1443 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Homez 34
  • 81.6 (n)
mouse
(Mus musculus)
Mammalia Homez 34 16 35
  • 80.21 (n)
oppossum
(Monodelphis domestica)
Mammalia HOMEZ 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOMEZ 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOMEZ 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii homez 35
  • 18 (a)
OneToMany
HOMEZ (1 of 2) 35
  • 14 (a)
OneToMany
Species where no ortholog for HOMEZ was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMEZ Gene

ENSEMBL:
Gene Tree for HOMEZ (if available)
TreeFam:
Gene Tree for HOMEZ (if available)

Paralogs for HOMEZ Gene

Paralogs for HOMEZ Gene

genes like me logo Genes that share paralogs with HOMEZ: view

Variants for HOMEZ Gene

Sequence variations from dbSNP and Humsavar for HOMEZ Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10131813 -- 23,276,324(+) AGAGG(C/T)GGCAG reference, missense
rs10133795 -- 23,280,407(+) GCTTA(A/T)CTTTT intron-variant
rs10136270 -- 23,280,365(+) GTCAC(C/T)AACAG intron-variant
rs10144278 -- 23,280,386(+) ACAGG(A/G)CAGAA intron-variant
rs1055061 -- 23,275,723(-) CTCTC(A/G)ATTAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for HOMEZ Gene

Variant ID Type Subtype PubMed ID
esv2763062 CNV gain 21179565

Variation tolerance for HOMEZ Gene

Residual Variation Intolerance Score: 52.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.30; 96.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOMEZ Gene

Human Gene Mutation Database (HGMD)
HOMEZ
SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOMEZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOMEZ Gene

Disorders for HOMEZ Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOMEZ Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ventricular septal defect
  • interventricular septal defect
- elite association - COSMIC cancer census association via MalaCards
Search HOMEZ in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOMEZ

Human Genome Epidemiology (HuGE) Navigator
HOMEZ
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOMEZ
genes like me logo Genes that share disorders with HOMEZ: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOMEZ Gene

Publications for HOMEZ Gene

  1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. (PMID: 12925734) Bayarsaihan D. … Ruddle F.H. (Proc. Natl. Acad. Sci. U.S.A. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for HOMEZ Gene

Sources for HOMEZ Gene

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