Aliases for HOMER3 Gene
Aliases for HOMER3 Gene
External Ids for HOMER3 Gene
- HGNC: 17514
- Entrez Gene: 9454
- Ensembl: ENSG00000051128
- OMIM: 604800
- UniProtKB: Q9NSC5
Previous GeneCards Identifiers for HOMER3 Gene
- GC19M019431
- GC19M018885
- GC19M018901
- GC19M019040
- GC19M018604
Summaries for HOMER3 Gene
-
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
GeneCards Summary for HOMER3 Gene
HOMER3 (Homer Scaffolding Protein 3) is a Protein Coding gene. Among its related pathways are Protein-protein interactions at synapses and FoxO signaling pathway. GO annotations related to this gene include protein domain specific binding and G-protein coupled glutamate receptor binding. An important paralog of this gene is HOMER1.
UniProtKB/Swiss-Prot for HOMER3 Gene
-
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMER3 Gene
Genomics for HOMER3 Gene
Regulatory Elements for HOMER3 Gene
Enhancers for HOMER3 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOMER3 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the HOMER3 gene promoter:
Regulatory Element Products
Genomic Location for HOMER3 Gene
- Chromosome:
- 19
- Start:
- 18,929,201 bp from pter
- End:
- 18,941,261 bp from pter
- Size:
- 12,061 bases
- Orientation:
- Minus strand
Genomic View for HOMER3 Gene
Genes around HOMER3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.11 by Ensembl
- 19p13.11 by Entrez Gene
- 19p13.11 by HGNC
HOMER3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOMER3 Gene
Proteins for HOMER3 Gene
-
Protein details for HOMER3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NSC5-HOME3_HUMAN
- Recommended name:
- Homer protein homolog 3
- Protein Accession:
- Q9NSC5
- E9PCW9
- O14580
- O95350
- Q9NSB9
- Q9NSC0
- Q9NSC1
Protein attributes for HOMER3 Gene
- Size:
- 361 amino acids
- Molecular mass:
- 39836 Da
- Quaternary structure:
-
- Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.
- SequenceCaution:
-
- Sequence=AAB81545.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for HOMER3 Gene
Post-translational modifications for HOMER3 Gene
Other Protein References for HOMER3 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for HOMER3
- Novus Biologicals Antibodies for HOMER3
-
Abcam antibodies for HOMER3
- Invitrogen Antibodies for HOMER3
- antibodies-online Antibodies for HOMER3: See all 57
- GeneTex HOMER3 antibody for HOMER3
-
Santa Cruz Biotechnology (SCBT) Antibodies for HOMER3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for HOMER3
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- ProSpec Recombinant Proteins for HOMER3
- antibodies-online Proteins for HOMER3: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOMER3
-
Abcam proteins for HOMER3
Assay Products
No data available for DME Specific Peptides for HOMER3 Gene
Domains & Families for HOMER3 Gene
Gene Families for HOMER3 Gene
Protein Domains for HOMER3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOMER3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NSC5UniProtKB/Swiss-Prot:
HOME3_HUMAN :- The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
- Belongs to the Homer family.
- Domain:
-
- The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
- Family:
-
- Belongs to the Homer family.
Function for HOMER3 Gene
Molecular function for HOMER3 Gene
- GENATLAS Biochemistry:
- homer,neuronal immediate early gene 3,constitutively expressed at excitating synapses,binding,clustering and linking metabotropic glutamate receptors group I with the inositol triphosphate receptors regulator of GRMs signaling
- UniProtKB/Swiss-Prot Function:
- Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16098226 |
| GO:0008022 | protein C-terminus binding | IEA | -- |
| GO:0019904 | protein domain specific binding | IEA | -- |
Phenotypes for HOMER3 Gene
- MGI mutant phenotypes for HOMER3:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOMER3:
Animal Models for HOMER3 Gene
- MGI Knock Outs for HOMER3:
-
- Homer3 tm1Mhd
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOMER3 gene
-
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- Search ViGene Biosciences for HOMER3
CRISPR Products
-
OriGene CRISPR knockouts for HOMER3
-
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miRNA Products
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Inhibitory RNA Products
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-
ViGene Biosciences ready-to-package AAV shRNAs for HOMER3 gene
Cell Line Products
-
Horizon Cell Lines for HOMER3
-
ViGene Biosciences adenoviral particle packaged cDNA for HOMER3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOMER3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOMER3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HOMER3 Gene
Localization for HOMER3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOMER3 Gene
- Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| plasma membrane | 4 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0014069 | postsynaptic density | IEA | -- |
Pathways & Interactions for HOMER3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Protein-protein interactions at synapses | ||
| 2 | FoxO signaling pathway | ||
| 3 | Circadian entrainment | ||
| 4 | Transmission across Chemical Synapses |
.62
|
|
Pathways by source for HOMER3 Gene
3 Reactome pathways for HOMER3 Gene
2 KEGG pathways for HOMER3 Gene
Interacting Proteins for HOMER3 Gene
Selected Interacting proteins:
ENSP00000376162
Q9NSC5-HOME3_HUMAN
for HOMER3 Gene via
STRING
UniProtKB
IID
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006605 | protein targeting | TAS | 10653696 |
| GO:0007216 | G-protein coupled glutamate receptor signaling pathway | TAS | 9808458 |
No data available for SIGNOR curated interactions for HOMER3 Gene
Drugs & Compounds for HOMER3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| calcium | Nutra | 0 |
Transcripts for HOMER3 Gene
mRNA/cDNA for HOMER3 Gene
- (6) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (199) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HOMER3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HOMER3
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOMER3
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miRNA Products
- Search ViGene Biosciences for HOMER3
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for HOMER3
- Browse OriGene Inhibitory RNA Products For HOMER3
-
ViGene Biosciences ready-to-package AAV shRNAs for HOMER3 gene
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 13d |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: | |
| SP12: |
Expression for HOMER3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
mRNA differential expression in normal tissues according to GTEx for HOMER3 Gene
This gene is overexpressed in Spleen (x4.5).
This gene is overexpressed in Spleen (41.5) and Monocytes (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOMER3 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOMER3 Gene:
HOMER3SOURCE GeneReport for Unigene cluster for HOMER3 Gene:
Hs.720208Evidence on tissue expression from TISSUES for HOMER3 Gene
- Nervous system(4.8)
- Muscle(2.6)
Primer Products
-
OriGene qPCR primer pairs for HOMER3
-
OriGene qPCR primer pairs and template standards for HOMER3
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOMER3 Gene
Orthologs for HOMER3 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOMER3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | HOMER3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOMER3 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Homer3 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Homer3 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOMER3 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | HOMER3 34 35 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | homer3 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | homer3-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | homer3 34 35 |
|
||
| zgc55557 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | homer 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for HOMER3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOMER3 Gene
(3) SIMAP similar genes for HOMER3 Gene using alignment to 6 proteins:
Variants for HOMER3 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000062098 | -- | 18,928,985(+) | TTTGG(A/C)CAGAC | downstream-variant-500B | |
| rs1000208428 | -- | 18,936,798(+) | TCCTG(A/G)CTAAC | intron-variant | |
| rs1000262151 | -- | 18,936,538(+) | TGGTG(C/T)GTCTG | intron-variant | |
| rs1000374083 | -- | 18,930,961(+) | TGAGA(G/T)CGTGC | intron-variant | |
| rs1000418128 | -- | 18,934,825(+) | TAGAG(A/G)CGGGG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2665463 | CNV | deletion | 23128226 |
| esv2667412 | CNV | deletion | 23128226 |
| esv3556142 | CNV | deletion | 23714750 |
| nsv1151217 | CNV | deletion | 26484159 |
| nsv470132 | CNV | loss | 18288195 |
| nsv833778 | CNV | loss | 17160897 |
| nsv952423 | CNV | deletion | 24416366 |
| nsv956592 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.62;
45.35% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOMER3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- HOMER3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOMER3 Gene
Disorders for HOMER3 Gene
Relevant External Links for HOMER3
No disorders were found for HOMER3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOMER3 Gene
Publications for HOMER3 Gene
- Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. (PMID: 10653696) Soloviev M. … McIlhinney R.A.J. (J. Mol. Biol. 2000) 2 3 4 22 64
- The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Homer-3 regulates activation of serum response element in T cells via its EVH1 domain. (PMID: 14645007) Ishiguro K. … Xavier R. (Blood 2004) 3 22 64
- Mutation screening of the Homer gene family and association analysis in schizophrenia. (PMID: 12815733) Norton N. … Owen M.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 46 64
Products for HOMER3 Gene
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- OriGene qPCR primer pairs for HOMER3
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- antibodies-online Antibodies for HOMER3: See all 57
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- ViGene Biosciences adenoviral particle packaged cDNA for HOMER3 gene
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- VectorBuilder custom plasmid, inducible vectors for HOMER3
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOMER3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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