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HOMER3 Gene

protein-coding   GIFtS: 59
GCID: GC19M019040

Homer Homolog 3 (Drosophila)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homer Homolog 3 (Drosophila)1 2
HOMER-32
VESL32
Homer Protein Homolog 32
Homer, Neuronal Immediate Early Gene, 32
Homer-33

External Ids:    HGNC: 175141   Entrez Gene: 94542   Ensembl: ENSG000000511287   OMIM: 6048005   UniProtKB: Q9NSC53   

Export aliases for HOMER3 gene to outside databases

Previous GC identifers: GC19M019431 GC19M018885 GC19M018901 GC19M018604


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOMER3 Gene:
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar
domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain
which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper
motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including
group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins
and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and
trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.(provided by
RefSeq, Mar 2009)

GeneCards Summary for HOMER3 Gene:
HOMER3 (homer homolog 3 (Drosophila)) is a protein-coding gene. Diseases associated with HOMER3 include stiff-person syndrome, and neuronitis. GO annotations related to this gene include protein C-terminus binding and protein domain specific binding. An important paralog of this gene is HOMER2.

UniProtKB/Swiss-Prot: HOME3_HUMAN, Q9NSC5
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5,
ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1
receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be
differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses

Gene Wiki entry for HOMER3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the HOMER3 gene promoter:
         AhR   HEN1   ER-alpha   Bach2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOMER3 promoter sequence
   Search Chromatin IP Primers for HOMER3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOMER3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1

HOMER3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOMER3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M019040:  view genomic region     (about GC identifiers)

Start:
19,040,010 bp from pter      End:
19,052,070 bp from pter
Size:
12,061 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: HOME3_HUMAN, Q9NSC5 (See protein sequence)
Recommended Name: Homer protein homolog 3  
Size: 361 amino acids; 39836 Da
Subunit: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization
Sequence caution: Sequence=AAB81545.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for HOMER3:
2P8V (3D)        3CVF (3D)    
Secondary accessions: E9PCW9 O14580 O95350 Q9NSB9 Q9NSC0 Q9NSC1
Alternative splicing: 5 isoforms:  Q9NSC5-1   Q9NSC5-2   Q9NSC5-3   Q9NSC5-4   Q9NSC5-5   

Explore the universe of human proteins at neXtProt for HOMER3: NX_Q9NSC5

Explore proteomics data for HOMER3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOMER3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001139193.1  NP_001139194.1  NP_001139196.1  NP_004829.3  

    ENSEMBL proteins: 
     ENSP00000221222   ENSP00000439937   ENSP00000376162   ENSP00000469800   ENSP00000471835  
     ENSP00000446026   ENSP00000472815   ENSP00000470659   ENSP00000472800   ENSP00000396154  
     ENSP00000348150  

    HOMER3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR000697 WH1/EVH1

    Graphical View of Domain Structure for InterPro Entry Q9NSC5

    ProtoNet protein and cluster: Q9NSC5

    UniProtKB/Swiss-Prot: HOME3_HUMAN, Q9NSC5
    Domain: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3
    Similarity: Belongs to the Homer family
    Similarity: Contains 1 WH1 domain


    HOMER3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HOME3_HUMAN, Q9NSC5
    Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5,
    ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1
    receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be
    differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses

         Genatlas biochemistry entry for HOMER3:
    homer,neuronal immediate early gene 3,constitutively expressed at excitating synapses,binding,clustering and
    linking metabotropic glutamate receptors group I with the inositol triphosphate receptors regulator of GRMs
    signaling

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16098226
    GO:0008022protein C-terminus binding IEA--
    GO:0019904protein domain specific binding IEA--
         
    HOMER3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for HOMER3:
     Increased circadian period len 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Homer3):
     behavior/neurological  integument 

    HOMER3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Homer3tm1Mhd for HOMER3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOMER3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOMER3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOMER3

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate HOMER3:
    hsa-miR-380
    SwitchGear 3'UTR luciferase reporter plasmidHOMER3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HOMER3

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HOME3_HUMAN, Q9NSC5: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic
    density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytoskeleton2
    cytosol2
    mitochondrion2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density IEA--

    HOMER3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HOMER3 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Glutamatergic synapse0.39
    2FoxO signaling pathway
    FoxO signaling pathway
    3Calcium channels
    Calcium channels

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for HOMER3):
        FoxO signaling pathway
    Glutamatergic synapse


    HOMER3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HOMER3
    Interactions:

        GeneGlobe Interaction Network for HOMER3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for HOMER3 (Q9NSC51, 2, 3 ENSP000003481504) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAT1Q145171, 2, 3, ENSP000004062294EBI-748420,EBI-1171918 MINT-3370401 MINT-3370454 MINT-3370427 MINT-3370268 I2D: score=2 STRING: ENSP00000406229
    APPP05067-81, ENSP000002849814EBI-748420,EBI-302661 I2D: score=1 STRING: ENSP00000284981
    PAX6P263671, 3, ENSP000003684014EBI-748420,EBI-747278 I2D: score=3 STRING: ENSP00000368401
    HOMER1Q86YM73, ENSP000003343824I2D: score=3 STRING: ENSP00000334382
    GRM1Q132553, ENSP000002827534I2D: score=2 STRING: ENSP00000282753
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006605protein targeting TAS10653696
    GO:0007216G-protein coupled glutamate receptor signaling pathway TAS9808458

    HOMER3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOMER3 (HOME3)

    1 HMDB Compound for HOMER3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for HOMER3 gene (4 alternative transcripts): 
    NM_001145721.1  NM_001145722.1  NM_001145724.1  NM_004838.3  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000221222(uc010eby.2) ENST00000539827(uc002nku.2) ENST00000392351(uc002nkv.2)
    ENST00000594794 ENST00000594439 ENST00000542541(uc010ebz.2) ENST00000595756
    ENST00000596482 ENST00000600077 ENST00000599808 ENST00000599097 ENST00000433218(uc002nkw.2)
    ENST00000355887(uc002nkp.1 uc002nko.1)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate HOMER3:
    hsa-miR-380
    SwitchGear 3'UTR luciferase reporter plasmidHOMER3 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat HOMER3
      QuantiFast Probe-based Assays in human, mouse, rat HOMER3

    Selected AceView cDNA sequences (see all 199):

    AL543131 CR618184 AL162098 BE909159 BG743298 Y18895 BG119617 CF132619 
    CR604554 CR601631 CR604813 AL134640 BM922300 AW606962 CR626845 CR617622 
    BU520777 BG681980 BI764673 AA505569 Y17573 BM718412 BX102949 BQ446944 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for HOMER3 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ·
    SP1:                    -     -     -     -                                                                                               -                     
    SP2:                                                                                                                                      -                     
    SP3:                                                                                                                                      -     -               
    SP4:                                                                                -     -                                               -                     
    SP5:        -     -     -     -     -     -                                                                                                                     

    ExUns: 13d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for HOMER3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOMER3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTTCACCA
    HOMER3 Expression
    About this image


    HOMER3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
     
     Heart (Cardiovascular System)
     
     Spleen (Hematopoietic System)
    HOMER3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOMER3 Protein Expression
        Custom PCR Arrays for HOMER3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMER3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOMER3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Homer31 , 5 homer homolog 3 (Drosophila)1, 5 82.77(n)1
    89.61(a)1
      8 (34.15 cM)5
    265581  NM_011984.21  NP_036114.21 
     702828275 
    chicken
    (Gallus gallus)
    Aves HOMER31 homer homolog 3 (Drosophila) 70.18(n)
    71.51(a)
      420115  XM_004948900.1  XP_004948957.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia homer3-prov2 homer homolog 3 (Drosophila) 78.96(n)    BC045262.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc555572 similar to homer homolog 3 (Drosophila) 75.27(n)   394088  BC045383.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta homer6
    homer
    34(a)
    1 → many
    2L(6719394-6723359)


    ENSEMBL Gene Tree for HOMER3 (if available)
    TreeFam Gene Tree for HOMER3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOMER3 gene
    HOMER22  HOMER12  
    3 SIMAP similar genes for HOMER3 using alignment to 6 protein entries:     HOME3_HUMAN (see all proteins):
    HOMER1    HOMER2    EVL

    HOMER3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOMER3 (see all 336)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844579961,2
    --18985965(+) GACGAC/TGGTAA 1 -- us2k10--------
    rs1910331921,2
    --18986376(+) TTTGAG/TACAAA 1 -- us2k10--------
    rs1458591171,2
    --18986425(+) ATCTCG/TGCTTA 2 -- us2k10--------
    rs1382332721,2
    C--18986575(+) GGTCTC/TGAACT 2 -- us2k10--------
    rs1807378531,2
    --18986576(+) GTCTCC/GAACTC 2 -- us2k10--------
    rs1863185361,2
    --18986608(+) CCCTCA/GGCTTC 2 -- us2k10--------
    rs1427385761,2
    --18986636(+) CAGACG/TTGAGC 2 -- us2k10--------
    rs1506491741,2
    --18986657(+) GGCCGA/GCACTT 2 -- us2k10--------
    rs1908256481,2
    --18986665(+) CTTGAA/GTGTTT 2 -- us2k10--------
    rs1852133741,2
    C--19039965(+) GCGCCA/GGCGAC 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for HOMER3 (19040010 - 19052070 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOMER3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665463CNV Deletion23128226
    esv2667412CNV Deletion23128226
    nsv470132CNV Loss18288195
    dgv3786n71CNV Loss21882294
    dgv3787n71CNV Loss21882294
    nsv833778CNV Loss17160897
    dgv3788n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604800    OMIM disorders: --

    3 diseases for HOMER3:    
    About MalaCards
    stiff-person syndrome    neuronitis    schizophrenia


    HOMER3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): HOMER3
    Human Genome Epidemiology (HuGE) Navigator: HOMER3 (1 document)

    Export disorders for HOMER3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOMER3 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with HOMER3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. (PubMed id 10653696)1, 2, 3, 9 Soloviev M.... McIlhinney R.A.J. (J. Mol. Biol. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    4. Mutation screening of the Homer gene family and association analysis in schizophrenia. (PubMed id 12815733)1, 4 Norton N....Owen M.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    5. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. (PubMed id 9808459)1, 3 Tu J.C.... Worley P.F. (Neuron 1998)
    6. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PubMed id 9808458)1, 2 Xiao B.... Worley P.F. (Neuron 1998)
    7. Homer-3 regulates activation of serum response element in T cells via its EVH1 domain. (PubMed id 14645007)1, 9 Ishiguro K. and Xavier R. (Blood 2004)
    8. Growth and differentiation effects of Homer3 on a leukemia cell line. (PubMed id 23725168)1 Li Z....Qi X.F. (Asian Pac. J. Cancer Prev. 2013)
    9. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    10. Proteasomal degradation of the metabotropic glutamate receptor 1I+ is mediated by Homer-3 via the proteasomal S8 ATPase: Signal transduction and synaptic transmission. (PubMed id 22486777)1 Rezvani K....Mayer R.J. (J. Neurochem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 9454 HGNC: 17514 AceView: HOMER3 Ensembl:ENSG00000051128 euGenes: HUgn9454
    ECgene: HOMER3 Kegg: 9454 H-InvDB: HOMER3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOMER3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for HOMER3 gene:
    Search GeneIP for patents involving HOMER3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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