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Aliases for HOMER3 Gene

Aliases for HOMER3 Gene

  • Homer Scaffolding Protein 3 2 3
  • HOMER-3 3 4
  • Homer, Neuronal Immediate Early Gene, 3 3
  • Homer Homolog 3 (Drosophila) 2
  • Homer Protein Homolog 3 3
  • Homer Homolog 3 3
  • VESL3 3

External Ids for HOMER3 Gene

Summaries for HOMER3 Gene

Entrez Gene Summary for HOMER3 Gene

  • This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

GeneCards Summary for HOMER3 Gene

HOMER3 (Homer Scaffolding Protein 3) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway and Circadian entrainment. GO annotations related to this gene include protein C-terminus binding and protein domain specific binding. An important paralog of this gene is HOMER1.

UniProtKB/Swiss-Prot for HOMER3 Gene

  • Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses

Gene Wiki entry for HOMER3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMER3 Gene

Genomics for HOMER3 Gene

Genomic Location for HOMER3 Gene

Start:
18,929,201 bp from pter
End:
18,941,261 bp from pter
Size:
12,061 bases
Orientation:
Minus strand

Genomic View for HOMER3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOMER3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMER3 Gene

Regulatory Elements for HOMER3 Gene

Proteins for HOMER3 Gene

  • Protein details for HOMER3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSC5-HOME3_HUMAN
    Recommended name:
    Homer protein homolog 3
    Protein Accession:
    Q9NSC5
    Secondary Accessions:
    • E9PCW9
    • O14580
    • O95350
    • Q9NSB9
    • Q9NSC0
    • Q9NSC1

    Protein attributes for HOMER3 Gene

    Size:
    361 amino acids
    Molecular mass:
    39836 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization
    SequenceCaution:
    • Sequence=AAB81545.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOMER3 Gene

    Alternative splice isoforms for HOMER3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOMER3 Gene

Proteomics data for HOMER3 Gene at MOPED

Post-translational modifications for HOMER3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for HOMER3 Gene

Domains for HOMER3 Gene

Protein Domains for HOMER3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOMER3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NSC5

UniProtKB/Swiss-Prot:

HOME3_HUMAN
Domain:
  • The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3:
    • Q9NSC5
  • Contains 1 WH1 domain.:
    • Q9NSC5
Family:
  • Belongs to the Homer family.:
    • Q9NSC5
genes like me logo Genes that share domains with HOMER3: view

No data available for Gene Families for HOMER3 Gene

Function for HOMER3 Gene

Molecular function for HOMER3 Gene

GENATLAS Biochemistry: homer,neuronal immediate early gene 3,constitutively expressed at excitating synapses,binding,clustering and linking metabotropic glutamate receptors group I with the inositol triphosphate receptors regulator of GRMs signaling
UniProtKB/Swiss-Prot Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses

Gene Ontology (GO) - Molecular Function for HOMER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16098226
GO:0008022 protein C-terminus binding IEA --
GO:0019904 protein domain specific binding IEA --
GO:0035256 G-protein coupled glutamate receptor binding IBA --
genes like me logo Genes that share ontologies with HOMER3: view

Phenotypes for HOMER3 Gene

MGI mutant phenotypes for HOMER3:
inferred from 1 alleles
GenomeRNAi human phenotypes for HOMER3:
genes like me logo Genes that share phenotypes with HOMER3: view

Animal Models for HOMER3 Gene

MGI Knock Outs for HOMER3:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HOMER3 Gene

Localization for HOMER3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMER3 Gene

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOMER3 Gene COMPARTMENTS Subcellular localization image for HOMER3 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 1

Gene Ontology (GO) - Cellular Components for HOMER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IDA --
GO:0014069 postsynaptic density --
genes like me logo Genes that share ontologies with HOMER3: view

Pathways for HOMER3 Gene

genes like me logo Genes that share pathways with HOMER3: view

Pathways by source for HOMER3 Gene

2 KEGG pathways for HOMER3 Gene

Gene Ontology (GO) - Biological Process for HOMER3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006605 protein targeting TAS 10653696
GO:0007216 G-protein coupled glutamate receptor signaling pathway TAS 9808458
GO:2001256 regulation of store-operated calcium entry IBA --
genes like me logo Genes that share ontologies with HOMER3: view

Compounds for HOMER3 Gene

(1) HMDB Compounds for HOMER3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with HOMER3: view

Transcripts for HOMER3 Gene

Unigene Clusters for HOMER3 Gene

Homer homolog 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOMER3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b · 13c ·
SP1: - - - - -
SP2: -
SP3: - -
SP4: - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - -
SP9: -
SP10:
SP11: - -
SP12:

ExUns: 13d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for HOMER3 Gene

GeneLoc Exon Structure for
HOMER3
ECgene alternative splicing isoforms for
HOMER3

Expression for HOMER3 Gene

mRNA expression in normal human tissues for HOMER3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOMER3 Gene

This gene is overexpressed in Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOMER3 Gene

SOURCE GeneReport for Unigene cluster for HOMER3 Gene Hs.720208

genes like me logo Genes that share expressions with HOMER3: view

No data available for mRNA Expression by UniProt/SwissProt for HOMER3 Gene

Orthologs for HOMER3 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOMER3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOMER3 35
  • 99.17 (n)
  • 99.17 (a)
HOMER3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOMER3 35
  • 87.71 (n)
  • 93.02 (a)
HOMER3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOMER3 35
  • 88.49 (n)
  • 94.15 (a)
HOMER3 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Homer3 35
  • 82.77 (n)
  • 89.61 (a)
Homer3 16
Homer3 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOMER3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Homer3 35
  • 83.71 (n)
  • 90.78 (a)
chicken
(Gallus gallus)
Aves HOMER3 35
  • 70.18 (n)
  • 71.51 (a)
HOMER3 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia homer3-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia homer3 35
  • 64.21 (n)
  • 65.72 (a)
zebrafish
(Danio rerio)
Actinopterygii homer3 35
  • 61.56 (n)
  • 56.65 (a)
homer3 36
  • 54 (a)
OneToOne
zgc55557 35
fruit fly
(Drosophila melanogaster)
Insecta homer 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for HOMER3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMER3 Gene

ENSEMBL:
Gene Tree for HOMER3 (if available)
TreeFam:
Gene Tree for HOMER3 (if available)

Paralogs for HOMER3 Gene

Paralogs for HOMER3 Gene

Selected SIMAP similar genes for HOMER3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HOMER3: view

Variants for HOMER3 Gene

Sequence variations from dbSNP and Humsavar for HOMER3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs886204 -- 18,932,440(+) TGGCT(C/T)TGGGC intron-variant
rs1059240 - 18,929,503(-) GTCAG(C/G)CTGTT reference, missense, nc-transcript-variant
rs1064351 -- 18,938,389(-) GTCTA(C/T)GGCCT reference, synonymous-codon, nc-transcript-variant
rs1122821 -- 18,940,148(-) CCCTG(C/T)GACCA intron-variant, utr-variant-5-prime, upstream-variant-2KB
rs3787043 -- 18,940,456(-) TAACC(C/G)CCCCG upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOMER3 Gene

Variant ID Type Subtype PubMed ID
dgv3786n71 CNV Loss 21882294
dgv3787n71 CNV Loss 21882294
nsv470132 CNV Loss 18288195
dgv3788n71 CNV Loss 21882294
nsv833778 CNV Loss 17160897
esv2665463 CNV Deletion 23128226
esv2667412 CNV Deletion 23128226

Relevant External Links for HOMER3 Gene

HapMap Linkage Disequilibrium report
HOMER3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOMER3 Gene

Disorders for HOMER3 Gene

Relevant External Links for HOMER3

Genetic Association Database (GAD)
HOMER3
Human Genome Epidemiology (HuGE) Navigator
HOMER3
genes like me logo Genes that share disorders with HOMER3: view

No data available for UniProtKB/Swiss-Prot for HOMER3 Gene

Publications for HOMER3 Gene

  1. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. (PMID: 10653696) Soloviev M. … McIlhinney R.A.J. (J. Mol. Biol. 2000) 2 3 4 23
  2. Homer-3 regulates activation of serum response element in T cells via its EVH1 domain. (PMID: 14645007) Ishiguro K. … Xavier R. (Blood 2004) 3 23
  3. Mutation screening of the Homer gene family and association analysis in schizophrenia. (PMID: 12815733) Norton N. … Owen M.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 48
  4. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PMID: 9808458) Xiao B. … Worley P.F. (Neuron 1998) 3 4
  5. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. (PMID: 9808459) Tu J.C. … Worley P.F. (Neuron 1998) 2 3

Products for HOMER3 Gene

Sources for HOMER3 Gene

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