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Aliases for HOMER2 Gene

Aliases for HOMER2 Gene

  • Homer Scaffolding Protein 2 2 3
  • HOMER-2 3 4
  • Cupidin 3 4
  • Homer, Neuronal Immediate Early Gene, 2 3
  • Homer Homolog 2 (Drosophila) 2
  • Homer Protein Homolog 2 3
  • Homer Homolog 2 3
  • Homer Homolog 3 3
  • HOMER2B 6
  • HOMER2A 6
  • VESL-2 3
  • ACPD 3
  • CPD 3

External Ids for HOMER2 Gene

Summaries for HOMER2 Gene

Entrez Gene Summary for HOMER2 Gene

  • This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]

GeneCards Summary for HOMER2 Gene

HOMER2 (Homer Scaffolding Protein 2) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is HOMER3.

UniProtKB/Swiss-Prot for HOMER2 Gene

  • Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses

Gene Wiki entry for HOMER2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMER2 Gene

Genomics for HOMER2 Gene

Genomic Location for HOMER2 Gene

Start:
82,836,946 bp from pter
End:
82,986,161 bp from pter
Size:
149,216 bases
Orientation:
Minus strand

Genomic View for HOMER2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOMER2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMER2 Gene

Regulatory Elements for HOMER2 Gene

Proteins for HOMER2 Gene

  • Protein details for HOMER2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSB8-HOME2_HUMAN
    Recommended name:
    Homer protein homolog 2
    Protein Accession:
    Q9NSB8
    Secondary Accessions:
    • O95269
    • O95349
    • Q9NSB6
    • Q9NSB7
    • Q9UNT7

    Protein attributes for HOMER2 Gene

    Size:
    354 amino acids
    Molecular mass:
    40627 Da
    Quaternary structure:
    • Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization
    SequenceCaution:
    • Sequence=CAB75539.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAB75540.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for HOMER2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOMER2 Gene

Proteomics data for HOMER2 Gene at MOPED

Post-translational modifications for HOMER2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOMER2 Gene

No data available for DME Specific Peptides for HOMER2 Gene

Domains for HOMER2 Gene

Protein Domains for HOMER2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

HOME2_HUMAN
Domain:
  • The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3:
    • Q9NSB8
  • Contains 1 WH1 domain.:
    • Q9NSB8
Family:
  • Belongs to the Homer family.:
    • Q9NSB8
genes like me logo Genes that share domains with HOMER2: view

No data available for Gene Families for HOMER2 Gene

Function for HOMER2 Gene

Molecular function for HOMER2 Gene

UniProtKB/Swiss-Prot Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses

Gene Ontology (GO) - Molecular Function for HOMER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0019904 protein domain specific binding IEA --
GO:0030160 GKAP/Homer scaffold activity IEA --
GO:0035254 glutamate receptor binding --
genes like me logo Genes that share ontologies with HOMER2: view
genes like me logo Genes that share phenotypes with HOMER2: view

Animal Models for HOMER2 Gene

MGI Knock Outs for HOMER2:

miRNA for HOMER2 Gene

miRTarBase miRNAs that target HOMER2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOMER2 Gene

Localization for HOMER2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMER2 Gene

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOMER2 Gene COMPARTMENTS Subcellular localization image for HOMER2 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for HOMER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with HOMER2: view

Pathways for HOMER2 Gene

genes like me logo Genes that share pathways with HOMER2: view

Pathways by source for HOMER2 Gene

Gene Ontology (GO) - Biological Process for HOMER2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007216 G-protein coupled glutamate receptor signaling pathway TAS 9808458
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0035584 calcium-mediated signaling using intracellular calcium source IEA --
GO:0048148 behavioral response to cocaine IEA --
GO:0048875 chemical homeostasis within a tissue IEA --
genes like me logo Genes that share ontologies with HOMER2: view

Compounds for HOMER2 Gene

(1) HMDB Compounds for HOMER2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with HOMER2: view

Transcripts for HOMER2 Gene

Unigene Clusters for HOMER2 Gene

Homer homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOMER2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - -
SP2: -
SP3:
SP4:

Relevant External Links for HOMER2 Gene

GeneLoc Exon Structure for
HOMER2
ECgene alternative splicing isoforms for
HOMER2

Expression for HOMER2 Gene

mRNA expression in normal human tissues for HOMER2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOMER2 Gene

This gene is overexpressed in Pancreas (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOMER2 Gene

SOURCE GeneReport for Unigene cluster for HOMER2 Gene Hs.578443

genes like me logo Genes that share expressions with HOMER2: view

Orthologs for HOMER2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOMER2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOMER2 36
  • 98.34 (n)
  • 98.85 (a)
HOMER2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HOMER2 36
  • 89.99 (n)
  • 96.5 (a)
HOMER2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOMER2 36
  • 90.81 (n)
  • 95.45 (a)
HOMER2 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Homer2 36
  • 89.92 (n)
  • 94.35 (a)
Homer2 16
Homer2 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOMER2 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOMER2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Homer2 36
  • 89.64 (n)
  • 95.2 (a)
chicken
(Gallus gallus)
Aves HOMER2 36
  • 78.41 (n)
  • 81.25 (a)
HOMER2 37
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOMER2 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia homer2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia homer2 36
  • 72.41 (n)
  • 74.86 (a)
Str.13680 36
zebrafish
(Danio rerio)
Actinopterygii homer2 36
  • 69.11 (n)
  • 67.83 (a)
HOMER2 37
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010076 36
  • 57.25 (n)
  • 57.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta homer 36
  • 60.2 (n)
  • 54.1 (a)
homer 37
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for HOMER2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMER2 Gene

ENSEMBL:
Gene Tree for HOMER2 (if available)
TreeFam:
Gene Tree for HOMER2 (if available)

Paralogs for HOMER2 Gene

Paralogs for HOMER2 Gene

Selected SIMAP similar genes for HOMER2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HOMER2 Gene

genes like me logo Genes that share paralogs with HOMER2: view

Variants for HOMER2 Gene

Sequence variations from dbSNP and Humsavar for HOMER2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs737327 -- 82,908,943(+) ACCAG(A/G)GAGCC intron-variant
rs750234 -- 82,908,941(+) ACACC(A/G)GGGAG intron-variant
rs869498 -- 82,916,650(-) CCTCT(A/G)CCGAC intron-variant
rs872598 -- 82,915,827(+) CAAAC(A/C)AACAA intron-variant
rs872599 -- 82,915,891(+) AGTAT(G/T)ATATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOMER2 Gene

Variant ID Type Subtype PubMed ID
nsv469557 CNV Complex 16826518
nsv471687 CNV Gain 15918152
nsv509578 CNV Insertion 20534489
esv2658853 CNV Deletion 23128226
nsv1641 CNV Insertion 18451855
esv2749958 CNV Deletion 23290073
esv269490 CNV Insertion 20981092
esv273062 CNV Insertion 20981092
esv2661148 CNV Deletion 23128226
nsv522673 CNV Loss 19592680
esv27643 CNV Loss 19812545

Relevant External Links for HOMER2 Gene

HapMap Linkage Disequilibrium report
HOMER2
Human Gene Mutation Database (HGMD)
HOMER2

Disorders for HOMER2 Gene

(1) University of Copenhagen DISEASES for HOMER2 Gene

Relevant External Links for HOMER2

Genetic Association Database (GAD)
HOMER2
Human Genome Epidemiology (HuGE) Navigator
HOMER2
genes like me logo Genes that share disorders with HOMER2: view

No data available for UniProtKB/Swiss-Prot for HOMER2 Gene

Publications for HOMER2 Gene

  1. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PMID: 9808458) Xiao B. … Worley P.F. (Neuron 1998) 2 3 4
  2. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. (PMID: 9808459) Tu J.C. … Worley P.F. (Neuron 1998) 2 3 4
  3. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. (PMID: 10653696) Soloviev M. … McIlhinney R.A.J. (J. Mol. Biol. 2000) 3 4
  4. Mutation screening of the Homer gene family and association analysis in schizophrenia. (PMID: 12815733) Norton N. … Owen M.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003) 3 49
  5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 49

Products for HOMER2 Gene

  • antibodies-online proteins for HOMER2
  • antibodies-online antibodies for HOMER2
  • antibodies-online kits for HOMER2

Sources for HOMER2 Gene

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