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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HOMER2 Gene

protein-coding   GIFtS: 61
GCID: GC15M083517

homer homolog 2 (Drosophila)
 Explore 10 diseases affiliated with
HOMER2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HOMER2    

Aliases
for HOMER2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Homer Homolog 2 (Drosophila)1 2     VESL-22
CPD1 2     Cupidin1 3
HOMER-21 2     Homer Homolog 32
Cupidin1 3     Homer Protein Homolog 22
HOMER-2A1     Homer, Neuronal Immediate Early Gene, 22
HOMER-2B1     Homer-23
Vesl-21     HOMER2A5
ACPD2     HOMER2B5

External Ids:    HGNC: 175131   Entrez Gene: 94552   Ensembl: ENSG000001039427   OMIM: 6047995   UniProtKB: Q9NSB83   

Export aliases for HOMER2 gene to outside databases

Previous GC identifers: GC15M076556 GC15M081102 GC15M081243 GC15M081314 GC15M059787


Summaries
for HOMER2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HOMER2:
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1
metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein.
Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on
chromosome 14. (provided by RefSeq, Jun 2011)

UniProtKB/Swiss-Prot: HOME2_HUMAN, Q9NSB8
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1,
DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids
the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its
interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the
plasticity at glutamatergic synapses

Gene Wiki entry for HOMER2


Genomic Views
for HOMER2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_077661.3  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HOMER2 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   CUTL1   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOMER2 promoter sequence
   Search SABiosciences Chromatin IP Primers for HOMER2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOMER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.3   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q24.3

HOMER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOMER2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M083517:  view genomic region     (about GC identifiers)

Start:
 83,509,838 bp from pter      End:
 83,654,661 bp from pter
Size:
 144,824 bases      Orientation:
 minus strand

Proteins
for HOMER2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HOME2_HUMAN, Q9NSB8 (See protein sequence)
Recommended Name: Homer protein homolog 2  
Size: 354 amino acids; 40627 Da
Subunit: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization
Subcellular location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell
junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic
glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface
Sequence caution: Sequence=CAB75539.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=CAB75540.1;
Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: O95269 O95349 Q9NSB6 Q9NSB7 Q9UNT7
Alternative splicing: 2 isoforms:  Q9NSB8-1   Q9NSB8-2   

Explore the universe of human proteins at neXtProt for HOMER2: NX_Q9NSB8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NSB8

    • HOMER2 Protein expression data from MOPED and PaxDb:    About this image 
    HOMER2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004830.2  NP_955362.1  

    ENSEMBL proteins: 
     ENSP00000452870   ENSP00000407634   ENSP00000305632   ENSP00000454125   ENSP00000394293  
     ENSP00000382119  

    Human Recombinant Protein Products for HOMER2: 
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    ProSpec Recombinant Protein for HOMER2
    Uscn Proteins for HOMER2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0030425dendrite ----

    HOMER2 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for HOMER2

    Protein Domains /
    Families
    for HOMER2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HOMER2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011993 PH_like_dom
     IPR000697 EVH1

    Graphical View of Domain Structure for InterPro Entry Q9NSB8

    ProtoNet protein and cluster: Q9NSB8

    UniProtKB/Swiss-Prot: HOME2_HUMAN, Q9NSB8
    Domain: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3
    Similarity: Belongs to the Homer family
    Similarity: Contains 1 WH1 domain


    Function
    for HOMER2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HOME2_HUMAN, Q9NSB8
    Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1,
    DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids
    the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its
    interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the
    plasticity at glutamatergic synapses

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding IEA--
    GO:0030160GKAP/Homer scaffold activity IEA--
    GO:0035256G-protein coupled glutamate receptor binding IEA--
         
    HOMER2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for HOMER2:
     Increased G2M DNA content  Increased HPV18 LCR reporter a  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Homer2):
     behavior/neurological  endocrine/exocrine gland  integument  nervous system 

    HOMER2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Homer2tm1Mhd for HOMER2
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOMER2 

    miRNA
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    hsa-miR-148b* hsa-miR-26a-2* hsa-miR-218-2* hsa-miR-938 hsa-miR-29b-1* hsa-miR-3150b-3p hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmid: HOMER2 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMER2


    Pathways & Interactions
    for HOMER2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Opioid Signalling
    		Glutamatergic synapse0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for HOMER2):
        Glutamatergic synapse


    HOMER2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HOMER2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/25 Interacting proteins for HOMER2 (Q9NSB83 ENSP000003056324) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBN1Q166433, ENSP000002923854I2D: score=2 STRING: ENSP00000292385
    RYR1P218173, ENSP000003526084I2D: score=2 STRING: ENSP00000352608
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    AGAP2Q994903, ENSP000003281604I2D: score=3 STRING: ENSP00000328160
    GRM1Q132553, ENSP000002827534I2D: score=3 STRING: ENSP00000282753
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007216G-protein coupled glutamate receptor signaling pathway TAS9808458
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IEA--
    GO:0035584calcium-mediated signaling using intracellular calcium source IEA--
    GO:0048148behavioral response to cocaine IEA--
    GO:0048875chemical homeostasis within a tissue IEA--

    HOMER2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for HOMER2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HOMER2

    1 HMDB Compound for HOMER2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Search CenterWatch for drugs/clinical trials and news about HOMER2 / HOME2 

    Transcripts
    for HOMER2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HOMER2 gene (4 alternative transcripts): 
    NM_004839.3  NM_199330.2  NM_199331.2  NM_199332.2  

    Unigene Cluster for HOMER2:

    Homer homolog 2 (Drosophila)
    Hs.578443  [show with all ESTs]
    Unigene Representative Sequence: AK097109
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558090 ENST00000450735 ENST00000304231(uc002bjg.3 uc002bjh.3)
    ENST00000558552 ENST00000558817 ENST00000561345 ENST00000560374 ENST00000500334(uc002bjk.1)
    ENST00000426485 ENST00000399166

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOMER2
    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate HOMER2 (see all 20):
    hsa-miR-148b* hsa-miR-26a-2* hsa-miR-218-2* hsa-miR-938 hsa-miR-29b-1* hsa-miR-3150b-3p hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmid: HOMER2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOMER2 (see all 7)
    OriGene shRNA RFP: HOMER2
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF081530.1 AF093263.1 AF093264.1 AK097109.1 AK292772.1 BC012109.1 Y19025.1 Y19026.1 
    Y19027.1 Y19028.1 

    11 DOTS entries:

    DT.75173149  DT.95168176  DT.92429014  DT.40192359  DT.100750116  DT.101968260  DT.100687810  DT.75123275 
    DT.95212024  DT.97791024  DT.99934174 

    24/107 AceView cDNA sequences (see all 107):

    NM_199331 Y19025 Y19026 BE466854 NM_199330 AW292549 BM999083 CA311167 
    AW473610 BG742654 AA872360 AI494460 BQ029752 NM_199332 BE746176 Y19027 
    BU685470 Y19028 BU625661 BU948968 BM069555 AI669649 CA313207 BU684669 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HOMER2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                          -                       -                           
    SP2:                                                  -                           
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for HOMER2

    Expression
    for HOMER2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HOMER2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTTCCGCCG
    HOMER2 Expression
    About this image

    HOMER2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Definitive endoderm-like cells (A scalable, suspensi...)

    See HOMER2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HOMER2

    SOURCE GeneReport for Unigene cluster: Hs.578443
        SABiosciences Expression via Pathway-Focused PCR Array including HOMER2: 
              GABA & Glutamate in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for HOMER2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for HOMER2 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HOMER21 homer homolog 2 (Drosophila) 78.4(n)
    80.94(a)    		   415458  XM_413836.3  XP_413836.3 
    lizard
    (Anolis carolinensis)    		 Reptilia HOMER26
    		 --
    		 80(a)
    		 1 ↔ 1
    		 GL343657.1(245493-284184)
    African clawed frog
    (Xenopus laevis)    		 Amphibia homer2-prov2 homer homolog 2 (Drosophila) 76.04(n)    BC046847.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii homer21 homer homolog 2 (Drosophila) 69.09(n)
    67.66(a)    		   553661  NM_001020634.1  NP_001018470.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta homer1 CG11324-PA 54.6(n)
    43.56(a)    		   33944  NM_001042876.1  NP_001036341.1 


    ENSEMBL Gene Tree for HOMER2 (if available)
    TreeFam Gene Tree for HOMER2 (if available) 

    Paralogs
    for HOMER2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HOMER2 gene
    HOMER32  HOMER12  
    2 SIMAP similar genes for HOMER2 using alignment to 4 protein entries:     HOME2_HUMAN (see all proteins):
    HOMER1    HOMER3

    HOMER2 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for HOMER2
    PGOHUM00000247933 PGOHUM00000247955 PGOHUM00000262073


    Genomic Variants
    for HOMER2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1603 NCBI SNPs in HOMER2 are shown (see all 1603)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs763186841,2
    		C,F--83517396(+) CAGCTG/TTCCAG 2 -- ds50012Minor allele frequency- T:0.04WA EA 238
    rs1424027691,2
    		--83517426(+) CCTAGA/GTACCA 2 -- ds50010--------
    rs789875351,2
    		--83517598(+) CCACCC/TGAGCC 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1511807171,2
    		--83517626(+) AGACAC/GTGGTA 2 -- ds50010--------
    rs1401826031,2
    		--83517735(+) ACACAC/TTTAAT 2 -- ut310--------
    rs1469391441,2
    		--83517828(+) CATCTA/GCTCAG 2 -- ut310--------
    rs1159092631,2
    		F--83517843(+) TAAAAC/TCAAGA 2 -- ut311Minor allele frequency- T:0.08WA 118
    rs1870999191,2
    		--83517880(+) ACTGGA/GGGGGC 2 -- ut310--------
    rs1379327721,2
    		--83517943(+) ACCCAC/TCAGAA 2 -- ut310--------
    rs1919073431,2
    		--83517966(+) TCTCTC/GAGAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HOMER2 (83509838 - 83654661 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for HOMER2
         3 CNVs: 35349 0789 72332
    Human Gene Mutation Database (HGMD): HOMER2

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    Disorders / Diseases
    for HOMER2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HOMER2 for disorders           About GeneDecksing

    OMIM gene information: 604799    OMIM disorders: --

    10 diseases for HOMER2:    About MalaCards
    congenital diaphragmatic hernia    cocaine dependence    neuronitis    alcohol dependence
    cerebellar ataxia    hernia    ataxia    alcoholism
    colorectal cancer    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for HOMER2:
    Congenital diaphragmatic hernia
    Genetic Association Database (GAD): HOMER2
    Human Genome Epidemiology (HuGE) Navigator: HOMER2 (5 documents)

    Export disorders for HOMER2 gene to outside databases

    Publications
    for HOMER2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HOMER2 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with HOMER2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. (PubMed id 9808459)1, 2, 3 Tu J.C....Worley P.F. (1998)
    2. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PubMed id 9808458)1, 2, 3 Xiao B.... Worley P.F. (1998)
    3. Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. (PubMed id 16314758)1, 4 Dahl J.P....Berrettini W.H. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Mutation screening of the Homer gene family and association analysis in schizophrenia. (PubMed id 12815733)1, 4 Norton N....Owen M.J. (2003)
    6. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. (PubMed id 10653696)1, 2 Soloviev M.... McIlhinney R.A.J. (2000)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Expression and regulation of Homer in human skeletal m uscle during neuromuscular junction adaptation to disuse and exercise. (PubMed id 21885651)1 Salanova M....Blottner D. (2011)
    9. Novel candidate colorectal cancer biomarkers identifi ed by methylation microarray-based scanning. (PubMed id 21636702)1 Mori Y....Meltzer S.J. (2011)
    10. Replicated genetic evidence supports a role for HOMER 2 in schizophrenia. (PubMed id 19914345)1 Gilks W.P.... D.W. (2010)

    External Searches for HOMER2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HOMER2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9455 HGNC: 17513 AceView: HOMER2 Ensembl:ENSG00000103942 euGenes: HUgn9455
    ECgene: HOMER2 Kegg: 9455 H-InvDB: HOMER2

    Other Databases showing HOMER2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HOMER2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HOMER2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for HOMER2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HOMER2 gene:
    Search GeneIP for patents involving HOMER2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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