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HOMER2 Gene

protein-coding   GIFtS: 61
GCID: GC15M083517

Homer Homolog 2 (Drosophila)

  Search for HOMER2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homer Homolog 2 (Drosophila)1 2     Homer Protein Homolog 22
ACPD2     Homer, Neuronal Immediate Early Gene, 22
CPD2     Cupidin3
HOMER-22     Homer-23
VESL-22     HOMER2A5
cupidin2     HOMER2B5
Homer Homolog 32     

External Ids:    HGNC: 175131   Entrez Gene: 94552   Ensembl: ENSG000001039427   OMIM: 6047995   UniProtKB: Q9NSB83   

Export aliases for HOMER2 gene to outside databases

Previous GC identifers: GC15M076556 GC15M081102 GC15M081243 GC15M081314 GC15M059787


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOMER2 Gene:
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1
metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein.
Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on
chromosome 14. (provided by RefSeq, Jun 2011)

GeneCards Summary for HOMER2 Gene:
HOMER2 (homer homolog 2 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include actin binding and protein homodimerization activity. An important paralog of this gene is HOMER3.

UniProtKB/Swiss-Prot: HOME2_HUMAN, Q9NSB8
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5,
ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1
receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to
PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important
role in maintaining the plasticity at glutamatergic synapses

Gene Wiki entry for HOMER2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOMER2 gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   CUTL1   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOMER2 promoter sequence
   Search Chromatin IP Primers for HOMER2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOMER2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.3   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q24.3

HOMER2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOMER2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M083517:  view genomic region     (about GC identifiers)

Start:
83,509,838 bp from pter      End:
83,654,661 bp from pter
Size:
144,824 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: HOME2_HUMAN, Q9NSB8 (See protein sequence)
Recommended Name: Homer protein homolog 2  
Size: 354 amino acids; 40627 Da
Subunit: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization
Sequence caution: Sequence=CAB75539.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=CAB75540.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: O95269 O95349 Q9NSB6 Q9NSB7 Q9UNT7
Alternative splicing: 2 isoforms:  Q9NSB8-1   Q9NSB8-2   

Explore the universe of human proteins at neXtProt for HOMER2: NX_Q9NSB8

Explore proteomics data for HOMER2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOMER2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004830.2  NP_955362.1  

    ENSEMBL proteins: 
     ENSP00000452870   ENSP00000407634   ENSP00000305632   ENSP00000454125   ENSP00000394293  
     ENSP00000382119  

    HOMER2 Human Recombinant Protein Products:

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    Novus Biologicals HOMER2 Proteins
    Novus Biologicals HOMER2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HOMER2
    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for HOMER2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR000697 WH1/EVH1

    Graphical View of Domain Structure for InterPro Entry Q9NSB8

    ProtoNet protein and cluster: Q9NSB8

    UniProtKB/Swiss-Prot: HOME2_HUMAN, Q9NSB8
    Domain: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3
    Similarity: Belongs to the Homer family
    Similarity: Contains 1 WH1 domain


    Find genes that share domains with HOMER2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HOME2_HUMAN, Q9NSB8
    Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5,
    ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1
    receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to
    PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important
    role in maintaining the plasticity at glutamatergic synapses

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding ----
    GO:0019904protein domain specific binding IEA--
    GO:0030160GKAP/Homer scaffold activity IEA--
    GO:0035254glutamate receptor binding ----
         
    Find genes that share ontologies with HOMER2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for HOMER2:
     Increased G2M DNA content  Increased HPV18 LCR reporter a  Increased number of mitotic ce 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Homer2):
     behavior/neurological  endocrine/exocrine gland  integument  nervous system 

    Find genes that share phenotypes with HOMER2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Homer2tm1Mhd for HOMER2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for HOMER2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for HOMER2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for HOMER2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for HOMER2

    miRNA
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    miRTarBase miRNAs that target HOMER2:
    hsa-mir-103a-2-5p (MIRT035764), hsa-mir-375 (MIRT019932)

    Block miRNA regulation of human, mouse, rat HOMER2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOMER2 (see all 20):
    hsa-miR-148b* hsa-miR-26a-2* hsa-miR-218-2* hsa-miR-938 hsa-miR-29b-1* hsa-miR-3150b-3p hsa-miR-129-3p hsa-miR-129*
    SwitchGear 3'UTR luciferase reporter plasmidHOMER2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat HOMER2

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    GenScript: all cDNA clones in your preferred vector (see all 4): HOMER2 (NM_199331)
    Sino Biological Human cDNA Clone for HOMER2
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMER2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HOME2_HUMAN, Q9NSB8: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell
    junction, synapse. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the
    metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane4
    cytosol3
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--
    GO:0014069postsynaptic density IEA--

    Find genes that share ontologies with HOMER2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HOMER2 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Glutamatergic synapse0.39
    2FoxO signaling pathway
    FoxO signaling pathway


    Find genes that share SuperPaths with HOMER2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for HOMER2):
        FoxO signaling pathway
    Glutamatergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Array including HOMER2: 
              GABA & Glutamate in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HOMER2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for HOMER2 (Q9NSB83 ENSP000003056324) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DBN1Q166433, ENSP000002923854I2D: score=2 STRING: ENSP00000292385
    HOMER1Q86YM73, ENSP000003343824I2D: score=2 STRING: ENSP00000334382
    RYR1P218173, ENSP000003526084I2D: score=2 STRING: ENSP00000352608
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    AGAP2Q994903, ENSP000003281604I2D: score=3 STRING: ENSP00000328160
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007216G-protein coupled glutamate receptor signaling pathway TAS9808458
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IEA--
    GO:0035584calcium-mediated signaling using intracellular calcium source IEA--
    GO:0048148behavioral response to cocaine IEA--
    GO:0048875chemical homeostasis within a tissue IEA--

    Find genes that share ontologies with HOMER2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOMER2 (HOME2)

    1 HMDB Compound for HOMER2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOMER2 gene (4 alternative transcripts): 
    NM_004839.3  NM_199330.2  NM_199331.2  NM_199332.2  

    Unigene Cluster for HOMER2:

    Homer homolog 2 (Drosophila)
    Hs.578443  [show with all ESTs]
    Unigene Representative Sequence: AK097109
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558090 ENST00000450735 ENST00000304231(uc002bjg.3 uc002bjh.3)
    ENST00000558552 ENST00000558817 ENST00000561345 ENST00000560374 ENST00000500334(uc002bjk.1)
    ENST00000426485 ENST00000399166
    miRNA
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    Block miRNA regulation of human, mouse, rat HOMER2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOMER2 (see all 20):
    hsa-miR-148b* hsa-miR-26a-2* hsa-miR-218-2* hsa-miR-938 hsa-miR-29b-1* hsa-miR-3150b-3p hsa-miR-129-3p hsa-miR-129*
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      QuantiTect SYBR Green Assays in human, mouse, rat HOMER2
      QuantiFast Probe-based Assays in human, mouse, rat HOMER2

    Additional mRNA sequence: 

    AF081530.1 AF093263.1 AF093264.1 AK097109.1 AK292772.1 BC012109.1 Y19025.1 Y19026.1 
    Y19027.1 Y19028.1 

    11 DOTS entries:

    DT.75173149  DT.95168176  DT.92429014  DT.40192359  DT.100750116  DT.101968260  DT.100687810  DT.75123275 
    DT.95212024  DT.97791024  DT.99934174 

    Selected AceView cDNA sequences (see all 107):

    BU685470 AI669649 AW473610 AI494460 NM_199330 NM_199332 BG742654 Y19027 
    BC012109 CB321822 BM069555 Y19025 AA872360 BE746176 BC044934 Y19026 
    NM_199331 BU684669 Y19028 CA313207 NM_004839 BE466854 BQ029752 AW292549 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HOMER2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                          -                       -                           
    SP2:                                                  -                           
    SP3:                                                                              
    SP4:                                                                              


    ECgene alternative splicing isoforms for HOMER2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOMER2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTCCGCCG
    HOMER2 Expression
    About this image


    HOMER2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Neural Tube (Nervous System)
             Spinal Ventral Columns
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
    HOMER2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOMER2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.578443
        Pathway & Disease-focused RT2 Profiler PCR Array including HOMER2: 
              GABA & Glutamate in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for HOMER2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMER2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOMER2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Homer21 , 5 homer homolog 2 (Drosophila)1, 5 89.92(n)1
    94.35(a)1
      7 (45.71 cM)5
    265571  NM_011983.21  NP_036113.11 
     816004815 
    chicken
    (Gallus gallus)
    Aves HOMER21 homer homolog 2 (Drosophila) 78.41(n)
    81.25(a)
      415458  XM_413836.4  XP_413836.4 
    lizard
    (Anolis carolinensis)
    Reptilia HOMER26
    homer homolog 2 (Drosophila)
    77(a)
    1 ↔ 1
    GL343657.1(245493-284780)
    African clawed frog
    (Xenopus laevis)
    Amphibia homer2-prov2 homer homolog 2 (Drosophila) 76.04(n)    BC046847.1 
    zebrafish
    (Danio rerio)
    Actinopterygii homer21 homer homolog 2 (Drosophila) 69.11(n)
    67.83(a)
      553661  NM_001020634.1  NP_001018470.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta homer1 homer 60.2(n)
    54.1(a)
      33944  NM_058048.4  NP_477396.1 


    ENSEMBL Gene Tree for HOMER2 (if available)
    TreeFam Gene Tree for HOMER2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOMER2 gene
    HOMER32  HOMER12  
    2 SIMAP similar genes for HOMER2 using alignment to 4 protein entries:     HOME2_HUMAN (see all proteins):
    HOMER3    HOMER1

    Find genes that share paralogs with HOMER2           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for HOMER2
    PGOHUM00000247933 PGOHUM00000247955 PGOHUM00000262073


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOMER2 (see all 1955)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs763186841,2
    C,F--83517396(+) CAGCTG/TTCCAG 2 -- ds50012Minor allele frequency- T:0.04WA EA 238
    rs1424027691,2
    --83517426(+) CCTAGA/GTACCA 2 -- ds50010--------
    rs789875351,2
    F--83517598(+) CCACCC/TGAGCC 2 -- ds50011Minor allele frequency- T:0.01WA 118
    rs1511807171,2
    C--83517626(+) AGACAC/GTGGTA 2 -- ds50010--------
    rs1401826031,2
    --83517735(+) ACACAC/TTTAAT 2 -- ut310--------
    rs1469391441,2
    C--83517828(+) CATCTA/GCTCAG 2 -- ut310--------
    rs1159092631,2
    F--83517843(+) TAAAAC/TCAAGA 2 -- ut311Minor allele frequency- T:0.08WA 118
    rs1870999191,2
    --83517880(+) ACTGGA/GGGGGC 2 -- ut310--------
    rs1379327721,2
    --83517943(+) ACCCAC/TCAGAA 2 -- ut310--------
    rs1919073431,2
    --83517966(+) TCTCTC/GAGAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for HOMER2 (83509838 - 83654661 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for HOMER2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749958CNV Deletion23290073
    esv2658853CNV Deletion23128226
    esv2661148CNV Deletion23128226
    esv269490CNV Insertion20981092
    nsv1641CNV Insertion18451855
    nsv509578CNV Insertion20534489
    esv273062CNV Insertion20981092
    esv27643CNV Loss19812545
    nsv522673CNV Loss19592680
    nsv471687CNV Gain15918152

    Human Gene Mutation Database (HGMD): HOMER2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOMER2
    DNA2.0 Custom Variant and Variant Library Synthesis for HOMER2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604799    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HOMER2:
    Congenital diaphragmatic hernia

    Find genes that share disorders with HOMER2           About GenesLikeMe

    Genetic Association Database (GAD): HOMER2
    Human Genome Epidemiology (HuGE) Navigator: HOMER2 (5 documents)

    Export disorders for HOMER2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOMER2 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with HOMER2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. (PubMed id 9808459)1, 2, 3 Tu J.C.... Worley P.F. (Neuron 1998)
    2. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PubMed id 9808458)1, 2, 3 Xiao B.... Worley P.F. (Neuron 1998)
    3. Replicated genetic evidence supports a role for HOMER2 in schizophrenia. (PubMed id 19914345)1, 4 Gilks W.P....Morris D.W. (Neurosci. Lett. 2010)
    4. No association of alcohol dependence with HOMER 1 and 2 genetic variants. (PubMed id 20333726)1, 4 Preuss U.W....Zill P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. (PubMed id 16314758)1, 4 Dahl J.P....Berrettini W.H. (Psychiatr. Genet. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Mutation screening of the Homer gene family and association analysis in schizophrenia. (PubMed id 12815733)1, 4 Norton N....Owen M.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    9. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. (PubMed id 10653696)1, 2 Soloviev M.... McIlhinney R.A.J. (J. Mol. Biol. 2000)
    10. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9455 HGNC: 17513 AceView: HOMER2 Ensembl:ENSG00000103942 euGenes: HUgn9455
    ECgene: HOMER2 Kegg: 9455 H-InvDB: HOMER2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOMER2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOMER2 gene:
    Search GeneIP for patents involving HOMER2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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