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Aliases for HOMER1 Gene

Aliases for HOMER1 Gene

  • Homer Scaffolding Protein 1 2 3 5
  • Homer-1 3 4
  • SYN47 3 4
  • Homer, Neuronal Immediate Early Gene, 1 3
  • Homer Homolog 1 (Drosophila) 2
  • Homer Protein Homolog 1 3
  • Homer Homolog 1 3
  • HOMER1A 3
  • HOMER1B 3
  • HOMER1C 3
  • HOMER 3
  • Ves-1 3

External Ids for HOMER1 Gene

Previous GeneCards Identifiers for HOMER1 Gene

  • GC05M078910
  • GC05M078708
  • GC05M078753
  • GC05M078755
  • GC05M078705
  • GC05M073877

Summaries for HOMER1 Gene

Entrez Gene Summary for HOMER1 Gene

  • This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOMER1 Gene

HOMER1 (Homer Scaffolding Protein 1) is a Protein Coding gene. Among its related pathways are Protein-protein interactions at synapses and Transmission across Chemical Synapses. GO annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is HOMER2.

UniProtKB/Swiss-Prot for HOMER1 Gene

  • Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

Gene Wiki entry for HOMER1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOMER1 Gene

Genomics for HOMER1 Gene

Regulatory Elements for HOMER1 Gene

Enhancers for HOMER1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F079556 0.7 ENCODE 11 -42.1 -42146 0.2 CTCF CEBPG ZNF2 RAD21 YY1 SCRT2 ZNF143 SMC3 NR2F6 GATAD2A HOMER1 THBS4 CTD-2201I18.1 ENSG00000277818 LOC105379047
GH05F079562 0.8 Ensembl ENCODE 10.6 -48.4 -48443 0.3 SP3 FEZF1 EBF1 ZEB2 ZNF843 ZNF2 ZNF24 KLF8 HOMER1 CMYA5 ENSG00000250258 THBS4 CTD-2201I18.1 ENSG00000277818 LOC105379047
GH05F079560 1.3 FANTOM5 Ensembl ENCODE 10.6 -47.2 -47158 1.3 IRF2 PKNOX1 HLF CEBPB ZNF175 JUNB CBX5 PBX2 TRIM24 IRF1 CMYA5 HOMER1 ENSG00000250258 THBS4 CTD-2201I18.1 PAPD4 ENSG00000277818 LOC105379047
GH05F079546 1.1 FANTOM5 ENCODE 5.5 -33.5 -33542 1.8 PKNOX1 FEZF1 RAD21 RARA RCOR1 FOS CREM ZNF263 NFYC CEBPB JMY HOMER1 PAPD4 CMYA5 LOC105379047 ENSG00000277818
GH05F079447 0.2 ENCODE 5.3 +65.5 65454 1.6 ZNF316 MAFK HOMER1 GC05M079453 LOC101929201
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around HOMER1 on UCSC Golden Path with GeneCards custom track

Promoters for HOMER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001411042 1017 4400 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for HOMER1 Gene

Chromosome:
5
Start:
79,372,636 bp from pter
End:
79,514,217 bp from pter
Size:
141,582 bases
Orientation:
Minus strand

Genomic View for HOMER1 Gene

Genes around HOMER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOMER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOMER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOMER1 Gene

Proteins for HOMER1 Gene

  • Protein details for HOMER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86YM7-HOME1_HUMAN
    Recommended name:
    Homer protein homolog 1
    Protein Accession:
    Q86YM7
    Secondary Accessions:
    • B2R688
    • O96003
    • Q86YM5

    Protein attributes for HOMER1 Gene

    Size:
    354 amino acids
    Molecular mass:
    40277 Da
    Quaternary structure:
    • Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization.

    Alternative splice isoforms for HOMER1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOMER1 Gene

Post-translational modifications for HOMER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOMER1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HOMER1 (HOMER1)

No data available for DME Specific Peptides for HOMER1 Gene

Domains & Families for HOMER1 Gene

Gene Families for HOMER1 Gene

Protein Domains for HOMER1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for HOMER1 Gene

Graphical View of Domain Structure for InterPro Entry

Q86YM7

UniProtKB/Swiss-Prot:

HOME1_HUMAN :
  • The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
  • Belongs to the Homer family.
Domain:
  • The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3.
  • Contains 1 WH1 domain.
Family:
  • Belongs to the Homer family.
genes like me logo Genes that share domains with HOMER1: view

Function for HOMER1 Gene

Molecular function for HOMER1 Gene

UniProtKB/Swiss-Prot Function:
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.

Gene Ontology (GO) - Molecular Function for HOMER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0035256 G-protein coupled glutamate receptor binding IBA --
GO:0035591 signaling adaptor activity IC 14505576
GO:0044325 ion channel binding IPI 14505576
genes like me logo Genes that share ontologies with HOMER1: view
genes like me logo Genes that share phenotypes with HOMER1: view

Animal Models for HOMER1 Gene

MGI Knock Outs for HOMER1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOMER1 Gene

Localization for HOMER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOMER1 Gene

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOMER1 Gene COMPARTMENTS Subcellular localization image for HOMER1 gene
Compartment Confidence
plasma membrane 4
cytosol 3
endoplasmic reticulum 2
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HOMER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with HOMER1: view

Pathways & Interactions for HOMER1 Gene

genes like me logo Genes that share pathways with HOMER1: view

Pathways by source for HOMER1 Gene

1 Cell Signaling Technology pathway for HOMER1 Gene
2 KEGG pathways for HOMER1 Gene

Gene Ontology (GO) - Biological Process for HOMER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003009 skeletal muscle contraction IEA --
GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway TAS 9808459
GO:0007268 chemical synaptic transmission TAS 9808458
GO:0009967 positive regulation of signal transduction IC 14505576
GO:0048148 behavioral response to cocaine IEA --
genes like me logo Genes that share ontologies with HOMER1: view

No data available for SIGNOR curated interactions for HOMER1 Gene

Drugs & Compounds for HOMER1 Gene

(2) Drugs for HOMER1 Gene - From: PharmGKB and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Levodopa Approved Pharma Agonist 388
calcium Nutra 0
genes like me logo Genes that share compounds with HOMER1: view

Transcripts for HOMER1 Gene

Unigene Clusters for HOMER1 Gene

Homer homolog 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOMER1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: -
SP2: - - - -
SP3: - - - -
SP4:

Relevant External Links for HOMER1 Gene

GeneLoc Exon Structure for
HOMER1
ECgene alternative splicing isoforms for
HOMER1

Expression for HOMER1 Gene

mRNA expression in normal human tissues for HOMER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOMER1 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.5) and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for HOMER1 Gene

This gene is overexpressed in Brain (18.7), Lung (16.9), Fetal Brain (10.3), and Frontal cortex (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOMER1 Gene



Protein tissue co-expression partners for HOMER1 Gene

NURSA nuclear receptor signaling pathways regulating expression of HOMER1 Gene:

HOMER1

SOURCE GeneReport for Unigene cluster for HOMER1 Gene:

Hs.591761
genes like me logo Genes that share expression patterns with HOMER1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HOMER1 Gene

Orthologs for HOMER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOMER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOMER1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia HOMER1 34 35
  • 96.42 (n)
cow
(Bos Taurus)
Mammalia HOMER1 34 35
  • 94.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HOMER1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Homer1 34 16 35
  • 91.15 (n)
rat
(Rattus norvegicus)
Mammalia Homer1 34
  • 89.55 (n)
oppossum
(Monodelphis domestica)
Mammalia HOMER1 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOMER1 34 35
  • 88.23 (n)
lizard
(Anolis carolinensis)
Reptilia HOMER1 35
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia homer1 34
  • 82.49 (n)
zebrafish
(Danio rerio)
Actinopterygii HOMER1 35
  • 80 (a)
OneToOne
homer1 34
  • 70.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta homer 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 40 (a)
OneToMany
Species where no ortholog for HOMER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOMER1 Gene

ENSEMBL:
Gene Tree for HOMER1 (if available)
TreeFam:
Gene Tree for HOMER1 (if available)

Paralogs for HOMER1 Gene

Paralogs for HOMER1 Gene

(2) SIMAP similar genes for HOMER1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOMER1: view

Variants for HOMER1 Gene

Sequence variations from dbSNP and Humsavar for HOMER1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035604 -- 79,444,014(+) CCTCA(A/G)ATAAA intron-variant
rs10038376 -- 79,398,184(+) CTGGG(A/G)GCCCA intron-variant
rs10039490 -- 79,445,107(+) AGGGA(A/G)ATAAA intron-variant
rs10042665 -- 79,479,276(+) GCCCC(C/G)AAAGA intron-variant
rs10050765 -- 79,472,305(+) AAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HOMER1 Gene

Variant ID Type Subtype PubMed ID
esv2730351 CNV deletion 23290073
esv2730352 CNV deletion 23290073
esv2730353 CNV deletion 23290073
esv3381279 CNV insertion 20981092
esv3605531 CNV gain 21293372
esv3890659 CNV gain 25118596
nsv1126063 CNV deletion 24896259
nsv462218 CNV gain 19166990
nsv472347 CNV novel sequence insertion 20440878
nsv598742 CNV gain 21841781

Variation tolerance for HOMER1 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOMER1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOMER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOMER1 Gene

Disorders for HOMER1 Gene

Relevant External Links for HOMER1

Genetic Association Database (GAD)
HOMER1
Human Genome Epidemiology (HuGE) Navigator
HOMER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOMER1

No disorders were found for HOMER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOMER1 Gene

Publications for HOMER1 Gene

  1. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PMID: 9808458) Xiao B. … Worley P.F. (Neuron 1998) 2 3 4 64
  2. No association of alcohol dependence with HOMER 1 and 2 genetic variants. (PMID: 20333726) Preuss U.W. … Zill P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64
  5. HOMER1 promoter analysis in Parkinson's disease: association study with psychotic symptoms. (PMID: 19648775) De Luca V. … Quattrone A. (Neuropsychobiology 2009) 3 46 64

Products for HOMER1 Gene

Sources for HOMER1 Gene

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