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HOMER1 Gene

protein-coding   GIFtS: 64
GCID: GC05M078705

Homer Homolog 1 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Homer Homolog 1 (Drosophila)1 2     Ves-12
SYN472 3     Homer Protein Homolog 12
HOMER1A2 5     Homer, Neuronal Immediate Early Gene, 12
HOMER1B2 5     homer-12
HOMER1C2 5     Homer-13
HOMER2     

External Ids:    HGNC: 175121   Entrez Gene: 94562   Ensembl: ENSG000001524137   OMIM: 6047985   UniProtKB: Q86YM73   

Export aliases for HOMER1 gene to outside databases

Previous GC identifers: GC05M078910 GC05M078708 GC05M078753 GC05M078755 GC05M073877


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOMER1 Gene:
This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1
metabotrophic glutamate receptor function. (provided by RefSeq, Jul 2008)

GeneCards Summary for HOMER1 Gene:
HOMER1 (homer homolog 1 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include ion channel binding and identical protein binding. An important paralog of this gene is HOMER3.

UniProtKB/Swiss-Prot: HOME1_HUMAN, Q86YM7
Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5,
ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1
receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to
PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of
GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform
1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that
occur at synapses during long-lasting neuronal plasticity and development

Gene Wiki entry for HOMER1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the HOMER1 gene promoter:
         POU2F2 (Oct-2.1)   Oct-B1   oct-B3   oct-B2   GATA-1   POU2F2   POU2F2C   POU2F1   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHOMER1 promoter sequence
   Search Chromatin IP Primers for HOMER1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOMER1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.2   Ensembl cytogenetic band:  5q14.1   HGNC cytogenetic band: 5q14.2

HOMER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOMER1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M078705:  view genomic region     (about GC identifiers)

Start:
78,668,459 bp from pter      End:
78,810,040 bp from pter
Size:
141,582 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HOME1_HUMAN, Q86YM7 (See protein sequence)
Recommended Name: Homer protein homolog 1  
Size: 354 amino acids; 40277 Da
Subunit: Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. Interacts with IFT57 and OPHN1.
Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization
Secondary accessions: B2R688 O96003 Q86YM5
Alternative splicing: 3 isoforms:  Q86YM7-1   Q86YM7-2   Q86YM7-3   

Explore the universe of human proteins at neXtProt for HOMER1: NX_Q86YM7

Explore proteomics data for HOMER1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOMER1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001264006.1  NP_001264007.1  NP_004263.1  

    ENSEMBL proteins: 
     ENSP00000334382   ENSP00000282260   ENSP00000426651   ENSP00000441587  

    HOMER1 Human Recombinant Protein Products:

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    Novus Biologicals HOMER1 Proteins
    Novus Biologicals HOMER1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for HOMER1
    Cloud-Clone Corp. Proteins for HOMER1

     
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    antibodies-online proteins for HOMER1 (8 products) 

     
    antibodies-online peptides for HOMER1

    HOMER1 Antibody Products:

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    antibodies-online antibodies for HOMER1 (46 products) 

    HOMER1 Assay Products:

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    Cloud-Clone Corp. ELISAs for HOMER1
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    antibodies-online kits for HOMER1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR000697 WH1/EVH1

    Graphical View of Domain Structure for InterPro Entry Q86YM7

    ProtoNet protein and cluster: Q86YM7

    UniProtKB/Swiss-Prot: HOME1_HUMAN, Q86YM7
    Domain: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3
    Similarity: Belongs to the Homer family
    Similarity: Contains 1 WH1 domain


    Find genes that share domains with HOMER1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HOME1_HUMAN, Q86YM7
    Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5,
    ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1
    receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to
    PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of
    GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform
    1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that
    occur at synapses during long-lasting neuronal plasticity and development

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding ----
    GO:0005515protein binding ----
    GO:0031802type 5 metabotropic glutamate receptor binding IEA--
    GO:0032947protein complex scaffold IEA--
    GO:0035256G-protein coupled glutamate receptor binding ----
         
    Find genes that share ontologies with HOMER1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for HOMER1:
     Decreased nuclei size in G2M  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Homer1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  integument  nervous system 

    Find genes that share phenotypes with HOMER1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Homer1tm1Mhd for HOMER1

       genOway: Develop your customized and physiologically relevant rodent model for HOMER1

    miRNA
    Products:
        
    miRTarBase miRNAs that target HOMER1:
    hsa-mir-484 (MIRT042276), hsa-let-7d-5p (MIRT032118)

    Block miRNA regulation of human, mouse, rat HOMER1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOMER1 (see all 54):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-765 hsa-miR-301a hsa-miR-759 hsa-miR-507 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidHOMER1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for HOMER1
    Predesigned siRNA for gene silencing in human, mouse, rat HOMER1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: HOMER1 (NM_004272)
    Sino Biological Human cDNA Clone for HOMER1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HOMER1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HOMER1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMER1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HOME1_HUMAN, Q86YM7: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic
    density (By similarity). Cell junction, synapse (By similarity). Note=Isoform 1 inhibits surface expression of
    GRM5 causing it to be retained in the endoplasmic reticulum (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane ----
    GO:0005887integral component of plasma membrane TAS9808459
    GO:0014069postsynaptic density ----
    GO:0016020membrane ----

    Find genes that share ontologies with HOMER1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HOMER1 About    
    See pathways by source

    SuperPathContained pathways About
    1Circadian entrainment
    Glutamatergic synapse0.39
    2Neuroscience
    Neuroscience
    3FoxO signaling pathway
    FoxO signaling pathway
    4Calcium channels
    Calcium channels


    Find genes that share SuperPaths with HOMER1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HOMER1
        Neuroscience



    2 Kegg Pathways  (Kegg details for HOMER1):
        FoxO signaling pathway
    Glutamatergic synapse

        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOMER1: 
              GABA & Glutamate in human mouse rat
              Huntington's Disease in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for HOMER1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for HOMER1 (Q86YM72, 3 ENSP000003343824) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABI3Q9P2A42, 3, ENSP000002259414MINT-66923 I2D: score=5 STRING: ENSP00000225941
    FAT1Q145172, 3, ENSP000004062294MINT-3370381 I2D: score=2 STRING: ENSP00000406229
    GRM5P415943, ENSP000003061384I2D: score=5 STRING: ENSP00000306138
    C1orf116Q9BW043, ENSP000003524474I2D: score=4 STRING: ENSP00000352447
    GRIK1P390863, ENSP000003827914I2D: score=2 STRING: ENSP00000382791
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003009skeletal muscle contraction IEA--
    GO:0006950response to stress ----
    GO:0007206phospholipase C-activating G-protein coupled glutamate receptor signaling pathway TAS9808459
    GO:0007216G-protein coupled glutamate receptor signaling pathway ----
    GO:0007268synaptic transmission TAS9808458

    Find genes that share ontologies with HOMER1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOMER1 (HOME1)

    1 HMDB Compound for HOMER1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOMER1 gene (3 alternative transcripts): 
    NM_001277077.1  NM_001277078.1  NM_004272.4  

    Unigene Cluster for HOMER1:

    Homer homolog 1 (Drosophila)
    Hs.591761  [show with all ESTs]
    Unigene Representative Sequence: NM_004272
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000334082(uc003kfy.3 uc010jab.3 uc010jac.3 uc010jad.3)
    ENST00000460741 ENST00000282260 ENST00000508576 ENST00000535690
    miRNA
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    Block miRNA regulation of human, mouse, rat HOMER1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate HOMER1 (see all 54):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-765 hsa-miR-301a hsa-miR-759 hsa-miR-507 hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidHOMER1 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat HOMER1
      QuantiFast Probe-based Assays in human, mouse, rat HOMER1

    Additional mRNA sequence: 

    AF093262.1 AK122857.1 AK223471.1 AK312481.1 AY189939.1 AY189940.1 AY189941.1 BC015502.1 
    BC047438.1 BT009846.1 Y17829.1 

    9 DOTS entries:

    DT.75101536  DT.75109798  DT.91711026  DT.100768833  DT.101982589  DT.209577  DT.100813533  DT.120822465 
    DT.40301351 

    Selected AceView cDNA sequences (see all 119):

    AI801123 BC015502 AI921612 AI688550 CB123055 CK299757 CB144034 AL119074 
    AW590406 Y17829 BM142423 CK820174 AI633260 BE019583 AA633526 AI337230 
    BF970445 BF034463 BT009846 BF512315 BQ955758 AW052119 AA547934 BM717789 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for HOMER1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                                      -                           
    SP2:                    -     -     -     -                           
    SP3:                                -     -     -     -               
    SP4:                                                                  


    ECgene alternative splicing isoforms for HOMER1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOMER1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAGAGCTG
    HOMER1 Expression
    About this image


    HOMER1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 4 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
    HOMER1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOMER1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591761
        Pathway & Disease-focused RT2 Profiler PCR Arrays including HOMER1: 
              GABA & Glutamate in human mouse rat
              Huntington's Disease in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for HOMER1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat HOMER1
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    QuantiFast Probe-based Assays in human, mouse, rat HOMER1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMER1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for HOMER1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Homer11 , 5 homer homolog 1 (Drosophila)1, 5 91.15(n)1
    98.59(a)1
      13 (47.83 cM)5
    265561  NM_001284189.11  NP_001271118.11 
     933037575 
    chicken
    (Gallus gallus)
    Aves HOMER11 homer homolog 1 (Drosophila) 88.23(n)
    97.74(a)
      427181  XM_424768.4  XP_424768.3 
    lizard
    (Anolis carolinensis)
    Reptilia HOMER16
    homer homolog 1 (Drosophila)
    95(a)
    1 ↔ 1
    2(12797078-12887899)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia homer11 homer homolog 1 82.49(n)
    92.66(a)
      100127824  NM_001113132.1  NP_001106603.1 
    zebrafish
    (Danio rerio)
    Actinopterygii homer11 homer homolog 1 (Drosophila) 70.92(n)
    76.49(a)
      100333527  XM_005165538.1  XP_005165595.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta homer6
    homer
    35(a)
    1 → many
    2L(6719394-6723359)


    ENSEMBL Gene Tree for HOMER1 (if available)
    TreeFam Gene Tree for HOMER1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOMER1 gene
    HOMER32  HOMER22  
    2 SIMAP similar genes for HOMER1 using alignment to 3 protein entries:     HOME1_HUMAN (see all proteins):
    HOMER3    HOMER2

    Find genes that share paralogs with HOMER1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOMER1 (see all 2800)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869208861,2
    --78669583(+) AAAGGA/TAACAA 3 -- ds50010--------
    rs1428639151,2
    C--78670022(+) CAGAGA/GAATAT 3 -- ut310--------
    rs1906883571,2
    --78670127(+) ACAGCA/TCATAT 3 -- ut310--------
    rs1509891541,2
    --78670140(+) TACATC/GATTGT 3 -- ut310--------
    rs2020004521,2
    C--78670305(+) GAGTG-/AAAAAA 3 -- ut310--------
    rs799045041,2
    C,F--78670716(+) AATCAA/GGATGT 3 -- ut311Minor allele frequency- G:0.03NA 120
    rs767926221,2
    C,F--78670759(+) CTCCAT/CCTCTA 3 -- ut312Minor allele frequency- C:0.16WA EA 238
    rs38225681,2
    C,F,H--78670802(-) ACAGCC/TGATCA 3 -- ut3133Minor allele frequency- N:0.00EA NA NS WA CSA 2859
    rs1828606611,2
    --78670871(+) CAGTTC/TCCCAA 3 -- ut310--------
    rs1409698701,2
    --78671006(+) TGACGA/GGCTGC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for HOMER1 (78668459 - 78810040 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for HOMER1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730351CNV Deletion23290073
    esv2730353CNV Deletion23290073
    esv2730352CNV Deletion23290073
    nsv882217CNV Loss21882294
    nsv882218CNV Loss21882294
    nsv882216CNV Loss21882294
    nsv462218CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOMER1
    DNA2.0 Custom Variant and Variant Library Synthesis for HOMER1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604798    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for HOMER1:
    Schizophrenia

    Find genes that share disorders with HOMER1           About GenesLikeMe

    Genetic Association Database (GAD): HOMER1
    Human Genome Epidemiology (HuGE) Navigator: HOMER1 (8 documents)

    Export disorders for HOMER1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOMER1 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with HOMER1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PubMed id 9808458)1, 2, 3 Xiao B.... Worley P.F. (Neuron 1998)
    2. No association of alcohol dependence with HOMER 1 and 2 genetic variants. (PubMed id 20333726)1, 4 Preuss U.W....Zill P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. HOMER1 promoter analysis in Parkinson's disease: association study with psychotic symptoms. (PubMed id 19648775)1, 4 De Luca V....Quattrone A. (Neuropsychobiology 2009)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Common variants in the GDF5-UQCC region are associated with variation in human height. (PubMed id 18193045)1, 4 Sanna S....Mohlke K.L. (Nat. Genet. 2008)
    7. Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. (PubMed id 16314758)1, 4 Dahl J.P....Berrettini W.H. (Psychiatr. Genet. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Mutation screening of the Homer gene family and association analysis in schizophrenia. (PubMed id 12815733)1, 4 Norton N....Owen M.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2003)
    10. Homer: a link between neural activity and glutamate receptor function. (PubMed id 10851183)1, 2 Xiao B.... Worley P.F. (Curr. Opin. Neurobiol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9456 HGNC: 17512 AceView: HOMER1 Ensembl:ENSG00000152413 euGenes: HUgn9456
    ECgene: HOMER1 Kegg: 9456 H-InvDB: HOMER1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOMER1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for HOMER1 gene:
    Search GeneIP for patents involving HOMER1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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