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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

HOMER1 Gene

protein-coding GIFtS: 63
GCID: GC05M078705

homer homolog 1 (Drosophila)

Explore 9 diseases affiliated with
HOMER1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Homer Homolog 1 (Drosophila)¹ ²		HOMER-1B¹
SYN47¹ ² ³		HOMER²
Ves-1¹ ²		Homer Protein Homolog 1²
HOMER1A² ⁵		Homer, Neuronal Immediate Early Gene, 1²
HOMER1B² ⁵		Homer-1³
HOMER1C² ⁵		Homer-1³

External Ids:	HGNC: 17512¹	Entrez Gene: 9456²	Ensembl: ENSG00000152413⁷	OMIM: 604798⁵	UniProtKB: Q86YM7³

Export aliases for HOMER1 gene to outside databases

Previous GC identifers: GC05M078910 GC05M078708 GC05M078753 GC05M078755 GC05M073877

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HOMER1:

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1

metabotrophic glutamate receptor function. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: HOME1_HUMAN, Q86YM7

Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1,

DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids

the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its

interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a

natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic

metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during

long-lasting neuronal plasticity and development

Gene Wiki entry for HOMER1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the HOMER1 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 GATA-1 POU2F2 POU2F2C POU2F1 POU2F1a POU2F2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HOMER1 promoter sequence

Search SABiosciences Chromatin IP Primers for HOMER1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HOMER1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.2 Ensembl cytogenetic band: 5q14.1 HGNC cytogenetic band: 5q14.2

HOMER1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOMER1 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M078705: view genomic region (about GC identifiers)

Start:	78,668,459 bp from pter	End:	78,810,040 bp from pter
Size:	141,582 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HOME1_HUMAN, Q86YM7 (See protein sequence)

Recommended Name: Homer protein homolog 1

Size: 354 amino acids; 40277 Da

Subunit: Interacts with IFT57 (By similarity). Interacts with OPHN1 (By similarity). Isoform 1 encodes a coiled-coil

structure that mediates homo- and heteromultimerization

Subcellular location: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic

density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells. Isoform

1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum (By similarity)

Secondary accessions: B2R688 O96003 Q86YM5

Alternative splicing: 3 isoforms: Q86YM7-1 Q86YM7-2 Q86YM7-3

Explore the universe of human proteins at neXtProt for HOMER1: NX_Q86YM7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86YM7

HOMER1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004263.1

ENSEMBL proteins:

ENSP00000334382 ENSP00000426651 ENSP00000282260 ENSP00000441587

Human Recombinant Protein Products for HOMER1:

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	Novus Biologicals HOMER1 Proteins Novus Biologicals HOMER1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for HOMER1
	Uscn Proteins for HOMER1

Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005737	cytoplasm	--	--
GO:0005886	plasma membrane	--	--
GO:0005887	integral to plasma membrane	TAS	9808459
GO:0014069	postsynaptic density	IEA	--

HOMER1 for ontologies About GeneDecksing

HOMER1 Antibody Products:

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	ThermoFisher Antibody for HOMER1

Assay Products for HOMER1:

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	GenScript Custom Assay Services for HOMER1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for HOMER1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HOMER1 for domains About GeneDecksing

2 InterPro domains/families:

IPR011993 PH_like_dom

IPR000697 EVH1

Graphical View of Domain Structure for InterPro Entry Q86YM7

ProtoNet protein and cluster: Q86YM7

UniProtKB/Swiss-Prot: HOME1_HUMAN, Q86YM7

Domain: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3

Similarity: Belongs to the Homer family

Similarity: Contains 1 WH1 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: HOME1_HUMAN, Q86YM7

Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1,

DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids

the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its

interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a

natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic

metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during

long-lasting neuronal plasticity and development

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0031802	type 5 metabotropic glutamate receptor binding	IEA	--
GO:0032947	protein complex scaffold	IEA	--
GO:0035591	signaling adaptor activity	IC	14505576
GO:0042802	identical protein binding	IEA	--

HOMER1 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for HOMER1:

Decreased nuclei size in G2M

Synthetic lethal with Ras

5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Homer1):

behavior/neurological

endocrine/exocrine gland

homeostasis/metabolism

integument

nervous system

HOMER1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Homer1^tm1Mhd for HOMER1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for HOMER1

miRNA Products:		OriGene 3'-UTR Clone: HOMER1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOMER1
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate HOMER1 (see all 54):
		hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-765 hsa-miR-301a hsa-miR-759 hsa-miR-507 hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: HOMER1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HOMER1 (see all 7) OriGene shRNA RFP: HOMER1 OriGene siRNA: HOMER1
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for HOMER1
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for HOMER1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for HOMER1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMER1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Calcium channels

Calcium channels

1.00

Neuroscience

Neuroscience

1.00

Opioid Signalling

Glutamatergic synapse

0.31

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for HOMER1

Calcium channels

1 Cell Signaling Technology (CST) Pathway for HOMER1

Neuroscience

1 Kegg Pathway (Kegg details for HOMER1):

Glutamatergic synapse

HOMER1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for HOMER1

STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

5/29 Interacting proteins for HOMER1 (Q86YM7^{2, 3} ENSP00000334382⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 29)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABI3	Q9P2A4²^,³, ENSP00000225941⁴	MINT-66923 I2D: score=5 STRING: ENSP00000225941
FAT1	Q14517²^,³, ENSP00000406229⁴	MINT-3370381 I2D: score=2 STRING: ENSP00000406229
GRM5	P41594³, ENSP00000306138⁴	I2D: score=5 STRING: ENSP00000306138
C1orf116	Q9BW04³, ENSP00000352447⁴	I2D: score=4 STRING: ENSP00000352447
GRIK1	P39086³, ENSP00000382791⁴	I2D: score=2 STRING: ENSP00000382791

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003009	skeletal muscle contraction	IEA	--
GO:0006950	response to stress	IEA	--
GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway	TAS	9808459
GO:0007268	synaptic transmission	TAS	9808458
GO:0007623	circadian rhythm	IEA	--

HOMER1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for HOMER1

1 HMDB Compound for HOMER1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about HOMER1 / HOME1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for HOMER1 gene:

NM_004272.3

Unigene Cluster for HOMER1:

Homer homolog 1 (Drosophila)

Hs.591761 [show with all ESTs]

Unigene Representative Sequence: NM_004272

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000334082(uc003kfy.3 uc010jab.3 uc010jac.3 uc010jad.3)

ENST00000460741 ENST00000508576 ENST00000282260 ENST00000535690

miRNA Products:		OriGene 3'-UTR Clone: HOMER1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HOMER1
		8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate HOMER1 (see all 54):
		hsa-miR-548j hsa-miR-3607-3p hsa-miR-4254 hsa-miR-765 hsa-miR-301a hsa-miR-759 hsa-miR-507 hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: HOMER1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: HOMER1 (NM_004272)
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Additional cDNA sequence:

AF093262.1 AK122857.1 AK223471.1 AK312481.1 AY189939.1 AY189940.1 AY189941.1 BC015502.1

BC047438.1 BT009846.1 Y17829.1

8 DOTS entries:

DT.75101536 DT.91711026 DT.100768833 DT.101982589 DT.209577 DT.100813533 DT.120822465 DT.40301351

24/119 AceView cDNA sequences (see all 119):

AI688550 BC015502 AI801123 AI633260 AW590406 Y17829 BM142423 AI337230

AL119074 AA627591 AI921612 AA633526 AA985230 CB123055 CB144034 BM717789

BE550452 AW052119 BF512315 BE019583 AI620889 BF034463 NM_004272 CA396459

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for HOMER1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b
SP1:													-
SP2:							-		-		-		-
SP3:											-		-		-		-
SP4:

ECgene alternative splicing isoforms for HOMER1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

HOMER1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAGAGCTG

About this image

HOMER1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Skeletal Muscle

Hyoid Arch Muscles

Myoblasts

Skeletal Muscle

Mandibular Arch Muscles

Myoblasts

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See HOMER1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for HOMER1

SOURCE GeneReport for Unigene cluster: Hs.591761

SABiosciences Expression via Pathway-Focused PCR Arrays including HOMER1:

GABA & Glutamate in human mouse rat

Huntington's Disease in human mouse rat

Synaptic Plasticity in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HOMER1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOMER1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for HOMER1 gene from 5/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Homer1^{1 , 5}	homer homolog 1 (Drosophila)^{1, 5}	91.15(n)¹ 98.59(a)¹		13 (47.83 cM)⁵ 26556¹ NM_147176.2¹ NP_671705.2¹ 93303757⁵
chicken (Gallus gallus)	Aves	HOMER1¹	homer homolog 1 (Drosophila)	88.16(n) 97.73(a)		427181 XM_424768.3 XP_424768.2
lizard (Anolis carolinensis)	Reptilia	HOMER1⁶	--	95(a)	1 ↔ 1	2(12822540-12883809)
zebrafish (Danio rerio)	Actinopterygii	homer1¹	homer homolog 1 (Drosophila)	70.75(n) 76.35(a)		100333527 XM_002662105.2 XP_002662151.1
fruit fly (Drosophila melanogaster)	Insecta	homer⁶	homer	32(a)	1 → many	2L(6719394-6723359)

ENSEMBL Gene Tree for HOMER1 (if available)
TreeFam Gene Tree for HOMER1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for HOMER1 gene

HOMER3² HOMER2²

2 SIMAP similar genes for HOMER1 using alignment to 3 protein entries: HOME1_HUMAN (see all proteins):

HOMER3 HOMER2

HOMER1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186920886^1,2		--	78669583(+)	`AAAGGA/TAACAA`	1	--	ds500¹		0	--	--	--	--
rs142863915^1,2		--	78670022(+)	`CAGAGA/GAATAT`	1	--	ut3¹		0	--	--	--	--
rs190688357^1,2		--	78670127(+)	`ACAGCA/TCATAT`	1	--	ut3¹		0	--	--	--	--
rs150989154^1,2		--	78670140(+)	`TACATC/GATTGT`	1	--	ut3¹		0	--	--	--	--
rs202000452^1,2		--	78670305(+)	`GAGTG-/AAAAAA`	1	--	ut3¹		0	--	--	--	--
rs79904504^1,2	C,F	--	78670716(+)	`AATCAA/GGATGT`	1	--	ut3¹		1		NA	120
rs76792622^1,2	C,F	--	78670759(+)	`CTCCAT/CCTCTA`	1	--	ut3¹		2		WA EA	238
rs3822568^1,2	C,F,H	--	78670802(-)	`ACAGCC/TGATCA`	1	--	ut3¹		33		EA NA NS WA CSA	2859
rs182860661^1,2		--	78670871(+)	`CAGTTC/TCCCAA`	1	--	ut3¹		0	--	--	--	--
rs140969870^1,2		--	78671006(+)	`TGACGA/GGCTGC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for HOMER1 (78668459 - 78810040 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for HOMER1: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

HOMER1 for disorders           About GeneDecksing

OMIM gene information: 604798    OMIM disorders: --

9 diseases for HOMER1:    About MalaCards

cocaine dependence neuronitis alcohol dependence huntington's disease

parkinson's disease alcoholism choroiditis seizures

schizophrenia

1 disease from the University of Copenhagen DISEASES database for HOMER1:

Schizophrenia

Genetic Association Database (GAD): HOMER1
Human Genome Epidemiology (HuGE) Navigator: HOMER1 (8 documents)

Export disorders for HOMER1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for HOMER1 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with HOMER1)

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Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. (PubMed id 9808458)^{1, 2, 3} Xiao B.... Worley P.F. (1998)
Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. (PubMed id 16314758)^{1, 4} Dahl J.P....Berrettini W.H. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Mutation screening of the Homer gene family and association analysis in schizophrenia. (PubMed id 12815733)^{1, 4} Norton N....Owen M.J. (2003)
Homer: a link between neural activity and glutamate receptor function. (PubMed id 10851183)^{1, 2} Xiao B.... Worley P.F. (2000)
Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. (PubMed id 10464340)^{1, 2} Roche K.W....Worley P.F. (1999)
Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. (PubMed id 9808459)^{1, 3} Tu J.C....Worley P.F. (1998)
High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism. (PubMed id 22558107)¹ Kelleher R.J....Margulies D. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Expression and regulation of Homer in human skeletal m uscle during neuromuscular junction adaptation to disuse and exercise. (PubMed id 21885651)¹ Salanova M....Blottner D. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 9456	HGNC: 17512	AceView: HOMER1	Ensembl:ENSG00000152413	euGenes: HUgn9456
ECgene: HOMER1	Kegg: 9456	H-InvDB: HOMER1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for HOMER1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for HOMER1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for HOMER1 gene:
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homer homolog 1 (Drosophila)

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homer homolog 1 (Drosophila)

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