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Aliases for HOGA1 Gene

Aliases for HOGA1 Gene

  • 4-Hydroxy-2-Oxoglutarate Aldolase 1 2 3
  • DHDPSL 3 4 6
  • Dihydrodipicolinate Synthase-Like, Mitochondrial 2 3
  • N-Acetylneuraminate Pyruvate Lyase 2 (Putative) 2 3
  • Probable 2-Keto-4-Hydroxyglutarate Aldolase 3 4
  • Probable KHG-Aldolase 3 4
  • DHDPS-Like Protein 3 4
  • Protein 569272 3 4
  • C10orf65 3 4
  • HP3 3 6
  • Probable 4-Hydroxy-2-Oxoglutarate Aldolase, Mitochondrial 3
  • Dihydrodipicolinate Synthetase Homolog 2 (E. Coli) 2
  • 4-Hydroxy-2-Oxoglutarate Aldolase, Mitochondrial 3
  • Dihydrodipicolinate Synthetase Homolog 2 3
  • Chromosome 10 Open Reading Frame 65 2
  • Dihydrodipicolinate Synthase-Like 4
  • EC 4.1.3.16 4
  • DHDPS2 3
  • NPL2 3

External Ids for HOGA1 Gene

Previous Symbols for HOGA1 Gene

  • C10orf65
  • DHDPSL

Summaries for HOGA1 Gene

Entrez Gene Summary for HOGA1 Gene

  • The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for HOGA1 Gene

HOGA1 (4-Hydroxy-2-Oxoglutarate Aldolase 1) is a Protein Coding gene. Diseases associated with HOGA1 include hyperoxaluria, primary, type iii and primary hyperoxaluria. Among its related pathways are Arginine and proline metabolism and Glyoxylate and dicarboxylate metabolism. GO annotations related to this gene include protein homodimerization activity and 4-hydroxy-2-oxoglutarate aldolase activity. An important paralog of this gene is NPL.

UniProtKB/Swiss-Prot for HOGA1 Gene

  • Catalyzes the final step in the metabolic pathway of hydroxyproline.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOGA1 Gene

Genomics for HOGA1 Gene

Genomic Location for HOGA1 Gene

Start:
97,584,323 bp from pter
End:
97,612,802 bp from pter
Size:
28,480 bases
Orientation:
Plus strand

Genomic View for HOGA1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOGA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOGA1 Gene

No data available for Regulatory Elements for HOGA1 Gene

Proteins for HOGA1 Gene

  • Protein details for HOGA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XE5-HOGA1_HUMAN
    Recommended name:
    4-hydroxy-2-oxoglutarate aldolase, mitochondrial
    Protein Accession:
    Q86XE5
    Secondary Accessions:
    • A8K075
    • Q5T680
    • Q5T684
    • Q711P0
    • Q8N9F2
    • Q96EV5

    Protein attributes for HOGA1 Gene

    Size:
    327 amino acids
    Molecular mass:
    35249 Da
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=CAC84901.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15457.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HOGA1 Gene

    Alternative splice isoforms for HOGA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HOGA1 Gene

Proteomics data for HOGA1 Gene at MOPED

Post-translational modifications for HOGA1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOGA1 Gene

No data available for DME Specific Peptides for HOGA1 Gene

Domains for HOGA1 Gene

Protein Domains for HOGA1 Gene

UniProtKB/Swiss-Prot:

HOGA1_HUMAN
Family:
  • Belongs to the DapA family.:
    • Q86XE5
genes like me logo Genes that share domains with HOGA1: view

No data available for Gene Families for HOGA1 Gene

Function for HOGA1 Gene

Molecular function for HOGA1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by divalent cations.
UniProtKB/Swiss-Prot Function: Catalyzes the final step in the metabolic pathway of hydroxyproline.

Enzyme Numbers (IUBMB) for HOGA1 Gene

Gene Ontology (GO) - Molecular Function for HOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008700 4-hydroxy-2-oxoglutarate aldolase activity ISS --
GO:0016829 lyase activity --
GO:0042803 protein homodimerization activity IDA 21998747
genes like me logo Genes that share ontologies with HOGA1: view

miRNA for HOGA1 Gene

miRTarBase miRNAs that target HOGA1

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HOGA1 Gene

Localization for HOGA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOGA1 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for HOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS 21998747
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HOGA1: view

Pathways for HOGA1 Gene

genes like me logo Genes that share pathways with HOGA1: view

Pathways by source for HOGA1 Gene

1 BioSystems pathway for HOGA1 Gene

Interacting Proteins for HOGA1 Gene

Gene Ontology (GO) - Biological Process for HOGA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009436 glyoxylate catabolic process IMP 20797690
GO:0019470 4-hydroxyproline catabolic process IDA 21998747
GO:0033609 oxalate metabolic process IMP 21896830
GO:0042866 pyruvate biosynthetic process IDA 21998747
genes like me logo Genes that share ontologies with HOGA1: view

Transcripts for HOGA1 Gene

Unigene Clusters for HOGA1 Gene

4-hydroxy-2-oxoglutarate aldolase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOGA1 Gene

No ASD Table

Relevant External Links for HOGA1 Gene

GeneLoc Exon Structure for
HOGA1
ECgene alternative splicing isoforms for
HOGA1

Expression for HOGA1 Gene

mRNA expression in normal human tissues for HOGA1 Gene

mRNA differential expression in normal tissues according to GTEx for HOGA1 Gene

This gene is overexpressed in Kidney - Cortex (11.9), Liver (9.6), and Heart - Left Ventricle (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HOGA1 Gene

SOURCE GeneReport for Unigene cluster for HOGA1 Gene Hs.180346

genes like me logo Genes that share expressions with HOGA1: view

Orthologs for HOGA1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HOGA1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOGA1 36
  • 99.69 (n)
  • 99.69 (a)
cow
(Bos Taurus)
Mammalia HOGA1 36
  • 89.7 (n)
  • 89.91 (a)
HOGA1 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOGA1 36
  • 91.05 (n)
  • 92.9 (a)
HOGA1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoga1 36
  • 87.12 (n)
  • 89.41 (a)
Hoga1 16
Hoga1 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HOGA1 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOGA1 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoga1 36
  • 87.33 (n)
  • 88.47 (a)
chicken
(Gallus gallus)
Aves C10ORF65 36
  • 73.33 (n)
  • 72.33 (a)
HOGA1 37
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOGA1 37
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoga1 36
  • 68.46 (n)
  • 72.82 (a)
Str.8565 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2495 36
zebrafish
(Danio rerio)
Actinopterygii hoga1 36
  • 67.11 (n)
  • 70.13 (a)
hoga1 37
  • 65 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU09532 36
  • 44.17 (n)
  • 31.12 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7737 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7478 37
  • 57 (a)
OneToOne
Species with no ortholog for HOGA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOGA1 Gene

ENSEMBL:
Gene Tree for HOGA1 (if available)
TreeFam:
Gene Tree for HOGA1 (if available)

Paralogs for HOGA1 Gene

Paralogs for HOGA1 Gene

Selected SIMAP similar genes for HOGA1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOGA1: view

Variants for HOGA1 Gene

Sequence variations from dbSNP and Humsavar for HOGA1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs933057 -- 97,611,972(-) TTCCT(G/T)TCTGA utr-variant-3-prime
rs1010931 -- 97,601,035(+) AAGCA(C/T)TCACC intron-variant
rs1105999 -- 97,600,776(+) TTGAG(G/T)GACTT intron-variant
rs1124116 -- 97,611,390(-) GTAAC(C/T)GCCAA intron-variant
rs1812286 -- 97,612,104(-) GAGAA(C/T)CGCTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HOGA1 Gene

Variant ID Type Subtype PubMed ID
nsv7509 CNV Insertion 18451855
nsv818782 CNV Loss 17921354

Relevant External Links for HOGA1 Gene

HapMap Linkage Disequilibrium report
HOGA1
Human Gene Mutation Database (HGMD)
HOGA1

Disorders for HOGA1 Gene

(1) OMIM Diseases for HOGA1 Gene (613597)

UniProtKB/Swiss-Prot

HOGA1_HUMAN
  • Hyperoxaluria primary 3 (HP3) [MIM:613616]: A disorder phenotypically similar to hyperoxaluria type 1 and type 2. It is characterized by increase in urinary oxalate excretion and mild glycolic aciduria. Clinical manifestations include calcium oxalate urolithiasis, hematuria, pain, and/or urinary tract infection. {ECO:0000269 PubMed:20797690}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with HOGA1: view

Publications for HOGA1 Gene

  1. Mutations in DHDPSL are responsible for primary hyperoxaluria type III. (PMID: 20797690) Belostotsky R. … Frishberg Y. (Am. J. Hum. Genet. 2010) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. (PMID: 21998747) Riedel T.J. … Lowther W.T. (PLoS ONE 2011) 3 4

Products for HOGA1 Gene

Sources for HOGA1 Gene

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