Aliases for HOGA1 Gene
Aliases for HOGA1 Gene
- 4-Hydroxy-2-Oxoglutarate Aldolase 1 2 3 5
- Dihydrodipicolinate Synthase-Like, Mitochondrial 2 3
- N-Acetylneuraminate Pyruvate Lyase 2 (Putative) 2 3
- Probable 2-Keto-4-Hydroxyglutarate Aldolase 3 4
- Probable KHG-Aldolase 3 4
- DHDPS-Like Protein 3 4
- Protein 569272 3 4
- C10orf65 3 4
- DHDPSL 3 4
- Probable 4-Hydroxy-2-Oxoglutarate Aldolase, Mitochondrial 3
External Ids for HOGA1 Gene
- HGNC: 25155
- Entrez Gene: 112817
- Ensembl: ENSG00000241935
- OMIM: 613597
- UniProtKB: Q86XE5
Previous HGNC Symbols for HOGA1 Gene
- C10orf65
- DHDPSL
Previous GeneCards Identifiers for HOGA1 Gene
- GC10P099348
- GC10P099350
- GC10P099352
- GC10P099353
- GC10P099354
- GC10P099355
- GC10P099356
- GC10P099357
Summaries for HOGA1 Gene
-
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for HOGA1 Gene
HOGA1 (4-Hydroxy-2-Oxoglutarate Aldolase 1) is a Protein Coding gene. Diseases associated with HOGA1 include Hyperoxaluria, Primary, Type Iii and Primary Hyperoxaluria. Among its related pathways are Arginine and proline metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and 4-hydroxy-2-oxoglutarate aldolase activity. An important paralog of this gene is NPL.
UniProtKB/Swiss-Prot for HOGA1 Gene
-
Catalyzes the final step in the metabolic pathway of hydroxyproline.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOGA1 Gene
Genomics for HOGA1 Gene
Regulatory Elements for HOGA1 Gene
Enhancers for HOGA1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around HOGA1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for HOGA1 Gene
- Chromosome:
- 10
- Start:
- 97,584,323 bp from pter
- End:
- 97,612,802 bp from pter
- Size:
- 28,480 bases
- Orientation:
- Plus strand
Genomic View for HOGA1 Gene
Genes around HOGA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q24.2 by Ensembl
- 10q24.2 by Entrez Gene
- 10q24.2 by HGNC
HOGA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for HOGA1 Gene
Proteins for HOGA1 Gene
-
Protein details for HOGA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86XE5-HOGA1_HUMAN
- Recommended name:
- 4-hydroxy-2-oxoglutarate aldolase, mitochondrial
- Protein Accession:
- Q86XE5
- A8K075
- Q5T680
- Q5T684
- Q711P0
- Q8N9F2
- Q96EV5
Protein attributes for HOGA1 Gene
- Size:
- 327 amino acids
- Molecular mass:
- 35249 Da
- Quaternary structure:
-
- Homotetramer.
- SequenceCaution:
-
- Sequence=CAC84901.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15457.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for HOGA1 Gene
Post-translational modifications for HOGA1 Gene
Other Protein References for HOGA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for HOGA1
- Invitrogen Antibodies for HOGA1
- Search GeneTex for Antibodies for HOGA1
Protein Products
-
OriGene Purified Proteins for HOGA1
- Search Origene for MassSpec and Protein Over-expression Lysates for HOGA1
- Origene Custom Protein Services for HOGA1
- antibodies-online Proteins for HOGA1: See all 4
- Search antibodies-online for peptides
- Search GeneTex for Proteins for HOGA1
Assay Products
No data available for DME Specific Peptides for HOGA1 Gene
Domains & Families for HOGA1 Gene
Protein Domains for HOGA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for HOGA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86XE5- Family:
-
- Belongs to the DapA family.
No data available for Gene Families for HOGA1 Gene
Function for HOGA1 Gene
Molecular function for HOGA1 Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by divalent cations.
- UniProtKB/Swiss-Prot Function:
- Catalyzes the final step in the metabolic pathway of hydroxyproline.
Enzyme Numbers (IUBMB) for HOGA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008700 | 4-hydroxy-2-oxoglutarate aldolase activity | IDA,ISS | -- |
| GO:0016829 | lyase activity | IEA | -- |
| GO:0042803 | protein homodimerization activity | IDA | 21998747 |
Phenotypes for HOGA1 Gene
- MGI mutant phenotypes for HOGA1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for HOGA1:
Animal Models for HOGA1 Gene
- MGI Knock Outs for HOGA1:
-
- Hoga1 tm2a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for HOGA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOGA1 gene
- Search ViGene Biosciences for HOGA1
CRISPR Products
-
OriGene CRISPR knockouts for HOGA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOGA1
- GenScript: Design CRISPR guide RNA sequences for HOGA1
miRNA for HOGA1 Gene
- miRTarBase miRNAs that target HOGA1
miRNA Products
- Search ViGene Biosciences for HOGA1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOGA1
- Browse OriGene Inhibitory RNA Products For HOGA1
-
ViGene Biosciences ready-to-package AAV shRNAs for HOGA1 gene
Clone Products
- Sino Biological Human cDNA Clone for HOGA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for HOGA1
-
ViGene Biosciences adenoviral particle packaged cDNA for HOGA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for HOGA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for HOGA1 gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for HOGA1 Gene
Localization for HOGA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for HOGA1 Gene
- Mitochondrion.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | ISS | 21998747 |
| GO:0005759 | mitochondrial matrix | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0070062 | extracellular exosome | IDA | 23376485 |
Pathways & Interactions for HOGA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Arginine and proline metabolism | ||
| 2 | Glyoxylate and dicarboxylate metabolism | ||
| 3 | Metabolism | ||
Pathways by source for HOGA1 Gene
1 BioSystems pathway for HOGA1 Gene
3 KEGG pathways for HOGA1 Gene
Interacting Proteins for HOGA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008152 | metabolic process | IEA | -- |
| GO:0009436 | glyoxylate catabolic process | IMP | 20797690 |
| GO:0019470 | 4-hydroxyproline catabolic process | IDA | 21998747 |
| GO:0033609 | oxalate metabolic process | IMP | 21896830 |
| GO:0042866 | pyruvate biosynthetic process | IDA | 21998747 |
No data available for SIGNOR curated interactions for HOGA1 Gene
Drugs & Compounds for HOGA1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Pyruvic acid | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4-Hydroxy-2-oxoglutaric acid |
|
1187-99-1 |
|
|||
| Glyoxylic acid |
|
298-12-4 |
|
Transcripts for HOGA1 Gene
mRNA/cDNA for HOGA1 Gene
- (2) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (36) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for HOGA1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for HOGA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for HOGA1
- GenScript: Design CRISPR guide RNA sequences for HOGA1
miRNA Products
- Search ViGene Biosciences for HOGA1
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOGA1
- Browse OriGene Inhibitory RNA Products For HOGA1
-
ViGene Biosciences ready-to-package AAV shRNAs for HOGA1 gene
Clone Products
- Sino Biological Human cDNA Clone for HOGA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
Expression for HOGA1 Gene
mRNA differential expression in normal tissues according to GTEx for HOGA1 Gene
This gene is overexpressed in Kidney - Cortex (x11.9), Liver (x9.6), and Heart - Left Ventricle (x6.0).
This gene is overexpressed in Kidney (36.5), Islet of Langerhans (9.8), and Liver (8.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HOGA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of HOGA1 Gene:
HOGA1SOURCE GeneReport for Unigene cluster for HOGA1 Gene:
Hs.180346Evidence on tissue expression from TISSUES for HOGA1 Gene
- Kidney(4.5)
- Liver(4.2)
- Nervous system(4.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for HOGA1 Gene
Germ Layers:
- mesoderm
Systems:
- urinary
Organs:
Abdomen:
- kidney
Pelvis:
- ureter
Primer Products
-
OriGene qPCR primer pairs and template standards for HOGA1
-
OriGene qPCR primer pairs for HOGA1
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for HOGA1 Gene
Orthologs for HOGA1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | HOGA1 34 |
|
||
| dog (Canis familiaris) |
Mammalia | HOGA1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | HOGA1 35 34 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Hoga1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Hoga1 16 35 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | HOGA1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | HOGA1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C10ORF65 34 |
|
||
| HOGA1 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | HOGA1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | hoga1 34 |
|
||
| Str.8565 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | hoga1 35 34 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2495 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7478 35 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09532 34 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7737 34 |
|
- Species where no ortholog for HOGA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for HOGA1 Gene
(1) SIMAP similar genes for HOGA1 Gene using alignment to 2 proteins:
Variants for HOGA1 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs138207257 | Pathogenic, Hyperoxaluria primary 3 (HP3) [MIM:613616] | 97,611,535(+) | CCCAG(A/G/T)GCTGA | reference, missense | |
| rs267606764 | Pathogenic, Hyperoxaluria primary 3 (HP3) [MIM:613616] | 97,601,925(+) | GACTG(G/T)GCTGC | reference, missense | |
| rs149150736 | Pathogenic | 97,611,582(+) | CCTGC(C/T)GCGCC | reference, missense | |
| rs150702945 | Pathogenic | 97,598,900(+) | GATGC(A/C/G)AGTGT | intron-variant, reference, missense | |
| rs185803104 | Pathogenic | 97,600,168(+) | GGTAG(G/T)CCGCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1036494 | CNV | gain | 25217958 |
| nsv1047359 | CNV | gain | 25217958 |
| nsv1110852 | OTHER | inversion | 24896259 |
| nsv7509 | CNV | insertion | 18451855 |
| nsv818782 | CNV | loss | 17921354 |
Residual Variation Intolerance Score:
65.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.32;
26.27% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for HOGA1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOGA1 Gene
Disorders for HOGA1 Gene
(7) MalaCards diseases for HOGA1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyperoxaluria, primary, type iii |
|
|
| primary hyperoxaluria |
|
|
| inflammatory bowel disease 2 |
|
|
| inflammatory bowel disease 3 |
|
|
| inflammatory bowel disease 4 |
|
|
Search HOGA1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
HOGA1_HUMAN- Hyperoxaluria primary 3 (HP3) [MIM:613616]: A disorder phenotypically similar to hyperoxaluria type 1 and type 2. It is characterized by increase in urinary oxalate excretion and mild glycolic aciduria. Clinical manifestations include calcium oxalate urolithiasis, hematuria, pain, and/or urinary tract infection. {ECO:0000269 PubMed:20797690}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for HOGA1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- HOGA1
No data available for Genatlas for HOGA1 Gene
Publications for HOGA1 Gene
- Mutations in DHDPSL are responsible for primary hyperoxaluria type III. (PMID: 20797690) Belostotsky R. … Frishberg Y. (Am. J. Hum. Genet. 2010) 2 3 4 64
- Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. (PMID: 21998747) Riedel T.J. … Lowther W.T. (PLoS ONE 2011) 3 4 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
Products for HOGA1 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for HOGA1
- Search Origene for MassSpec and Protein Over-expression Lysates for HOGA1
- Origene Custom Protein Services for HOGA1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for HOGA1
- Browse OriGene Inhibitory RNA Products For HOGA1
- OriGene qPCR primer pairs and template standards for HOGA1
- OriGene qPCR primer pairs for HOGA1
- OriGene CRISPR knockouts for HOGA1
- OriGene ORF clones in human for HOGA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For HOGA1
- GenScript: Next-day shipping cDNA ORF clone for HOGA1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for HOGA1
- GenScript Custom Assay Services for HOGA1
- GenScript Custom overexpressing Cell Line Services for HOGA1
- GenScript: Design CRISPR guide RNA sequences for HOGA1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for HOGA1
- Sino Biological Human cDNA Clone for HOGA1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for HOGA1
- Novus Biologicals proteins and lysates for HOGA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for HOGA1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for HOGA1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for HOGA1 gene
- Search ViGene Biosciences for HOGA1
- Horizon Cell Lines for HOGA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for HOGA1
- VectorBuilder custom plasmid, inducible vectors for HOGA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for HOGA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for HOGA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer