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HOGA1 Gene

protein-coding   GIFtS: 48
GCID: GC10P099357

4-Hydroxy-2-Oxoglutarate Aldolase 1

(Previous names: chromosome 10 open reading frame 65, dihydrodipicolinate...)
(Previous symbols: C10orf65, DHDPSL)
  See HOGA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
4-Hydroxy-2-Oxoglutarate Aldolase 11 2     Chromosome 10 Open Reading Frame 651
DHDPSL1 2 3 5     Dihydrodipicolinate Synthetase Homolog 2 (E. Coli)1
C10orf651 2 3     4-Hydroxy-2-Oxoglutarate Aldolase, Mitochondrial2
Dihydrodipicolinate Synthase-Like, Mitochondrial1 2     DHDPS22
N-Acetylneuraminate Pyruvate Lyase 2 (Putative)1 2     NPL22
Probable 2-Keto-4-Hydroxyglutarate Aldolase2 3     Dihydrodipicolinate Synthetase Homolog 22
Probable KHG-Aldolase2 3     Probable 4-Hydroxy-2-Oxoglutarate Aldolase, Mitochondrial2
Protein 5692722 3     EC 4.1.3.163
DHDPS-Like Protein2 3     Dihydrodipicolinate Synthase-Like3
HP32 5     

External Ids:    HGNC: 251551   Entrez Gene: 1128172   Ensembl: ENSG000002419357   OMIM: 6135975   UniProtKB: Q86XE53   

Export aliases for HOGA1 gene to outside databases

Previous GC identifers: GC10P099348 GC10P099350 GC10P099352 GC10P099353 GC10P099354 GC10P099355 GC10P099356


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for HOGA1 Gene:
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to
primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a
mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli
dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither
lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate
mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16),
which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate.
This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients
with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have
been noted for this gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for HOGA1 Gene:
HOGA1 (4-hydroxy-2-oxoglutarate aldolase 1) is a protein-coding gene. Diseases associated with HOGA1 include primary hyperoxaluria type 3, and primary hyperoxaluria. GO annotations related to this gene include 4-hydroxy-2-oxoglutarate aldolase activity and protein homodimerization activity. An important paralog of this gene is NPL.

UniProtKB/Swiss-Prot: HOGA1_HUMAN, Q86XE5
Function: Catalyzes the final step in the metabolic pathway of hydroxyproline




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Search for regulatory transcription factor binding sites for HOGA1
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for HOGA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat HOGA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.2   Ensembl cytogenetic band:  10q24.2   HGNC cytogenetic band: 10q24.1

HOGA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HOGA1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P099357:  view genomic region     (about GC identifiers)

Start:
99,344,080 bp from pter      End:
99,372,559 bp from pter
Size:
28,480 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: HOGA1_HUMAN, Q86XE5 (See protein sequence)
Recommended Name: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial precursor  
Size: 327 amino acids; 35249 Da
Subunit: Homotetramer (By similarity)
Sequence caution: Sequence=CAC84901.1; Type=Erroneous gene model prediction; Sequence=CAI15457.1; Type=Erroneous
gene model prediction;
2 PDB 3D structures from and Proteopedia for HOGA1:
3S5N (3D)        3S5O (3D)    
Secondary accessions: A8K075 Q5T680 Q5T684 Q711P0 Q8N9F2 Q96EV5
Alternative splicing: 2 isoforms:  Q86XE5-1   Q86XE5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HOGA1: NX_Q86XE5

Explore proteomics data for HOGA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See HOGA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128142.1  NP_612422.2  

    ENSEMBL proteins: 
     ENSP00000359681   ENSP00000359680   ENSP00000359676  

    HOGA1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for HOGA1 

     
    antibodies-online proteins for HOGA1 (3 products) 

     
    Search antibodies-online for peptides for HOGA1

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    antibodies-online antibodies for HOGA1 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR020625 Dihydrodipicolinate_synth_AS
     IPR002220 DapA-like

    Graphical View of Domain Structure for InterPro Entry Q86XE5

    ProtoNet protein and cluster: Q86XE5

    1 Blocks protein domain: IPB002220 Dihydrodipicolinate synthetase

    UniProtKB/Swiss-Prot: HOGA1_HUMAN, Q86XE5
    Similarity: Belongs to the DapA family


    Find genes that share domains with HOGA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HOGA1_HUMAN, Q86XE5
    Function: Catalyzes the final step in the metabolic pathway of hydroxyproline
    Catalytic activity: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate
    Enzyme regulation: Inhibited by divalent cations (By similarity)

         Enzyme Number (IUBMB): EC 4.1.3.161

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:00087004-hydroxy-2-oxoglutarate aldolase activity ISS--
    GO:0016829lyase activity ----
    GO:0042803protein homodimerization activity IDA--
         
    Find genes that share ontologies with HOGA1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for HOGA1

    miRNA
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    miRTarBase miRNAs that target HOGA1:
    hsa-mir-92a-3p (MIRT049270)

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    7 qRT-PCR Assays for microRNAs that regulate HOGA1:
    hsa-miR-3934 hsa-miR-3673 hsa-miR-4254 hsa-miR-3116 hsa-miR-519e hsa-miR-515-3p hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmidHOGA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    HOGA1_HUMAN, Q86XE5: Mitochondrion (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--

    Find genes that share ontologies with HOGA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for HOGA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Arginine and proline metabolism
    Arginine and proline metabolism
    4-hydroxyproline degradation I0.00
    2Glyoxylate and dicarboxylate metabolism
    Glyoxylate and dicarboxylate metabolism


    Find genes that share SuperPaths with HOGA1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for HOGA1
        4-hydroxyproline degradation I


    2 Kegg Pathways  (Kegg details for HOGA1):
        Arginine and proline metabolism
    Glyoxylate and dicarboxylate metabolism

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for HOGA1
    Interactions:

        Search GeneGlobe Interaction Network for HOGA1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for HOGA1 (ENSP000003596804) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAICSENSP000003825954STRING: ENSP00000382595
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0009436glyoxylate catabolic process IMP--
    GO:00194704-hydroxyproline catabolic process IDA--
    GO:0033609oxalate metabolic process IMP--
    GO:0042866pyruvate biosynthetic process IDA--

    Find genes that share ontologies with HOGA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for HOGA1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for HOGA1 gene (2 alternative transcripts): 
    NM_001134670.1  NM_138413.3  

    Unigene Cluster for HOGA1:

    4-hydroxy-2-oxoglutarate aldolase 1
    Hs.180346  [show with all ESTs]
    Unigene Representative Sequence: NM_138413
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000465608(uc001knx.2) ENST00000370647(uc001knz.3) ENST00000370646(uc001kny.3)
    ENST00000370642
    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate HOGA1:
    hsa-miR-3934 hsa-miR-3673 hsa-miR-4254 hsa-miR-3116 hsa-miR-519e hsa-miR-515-3p hsa-miR-616
    SwitchGear 3'UTR luciferase reporter plasmidHOGA1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat HOGA1

    Additional mRNA sequence: 

    AK289440.1 BC011916.2 BC045550.1 BC057821.1 

    4 DOTS entries:

    DT.95372143  DT.101980393  DT.99933316  DT.95151648 

    Selected AceView cDNA sequences (see all 36):

    BX097583 BX281317 BM006098 BC011916 AK094791 BM005711 CA430030 BI549804 
    BI764563 BC045550 BC057821 BI765630 BI761505 BI759683 R89840 BE384660 
    NM_138413 BI547728 BI252088 BP334104 BF569272 BI763832 BG166577 BG165743 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    HOGA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTCGCCTC
    HOGA1 Expression
    About this image

    HOGA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    HOGA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.180346
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HOGA1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for HOGA1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Hoga11 , 5 4-hydroxy-2-oxoglutarate aldolase 11, 5 87.12(n)1
    89.41(a)1
      19 (35.67 cM)5
    674321  NM_026152.11  NP_080428.11 
     420456105 
    chicken
    (Gallus gallus)
    Aves C10ORF651 4-hydroxy-2-oxoglutarate aldolase 1 73.33(n)
    72.33(a)
      770036  XM_001233351.3  XP_001233352.2 
    lizard
    (Anolis carolinensis)
    Reptilia HOGA16
    4-hydroxy-2-oxoglutarate aldolase 1
    53(a)
    1 ↔ 1
    3(39228706-39243219)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.85652 Transcribed sequence with moderate similarity to protein more 73.84(n)    CF375968.1 
    zebrafish
    (Danio rerio)
    Actinopterygii hoga11 4-hydroxy-2-oxoglutarate aldolase 1 67.11(n)
    70.13(a)
      405806  NM_212870.1  NP_998035.1 


    ENSEMBL Gene Tree for HOGA1 (if available)
    TreeFam Gene Tree for HOGA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for HOGA1 gene
    NPL2  
    1 SIMAP similar gene for HOGA1 using alignment to 2 protein entries:     HOGA1_HUMAN (see all proteins):
    PI4K2A

    Find genes that share paralogs with HOGA1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for HOGA1 (see all 769)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0640364
    Hyperoxaluria primary 3 (HP3)4--see VAR_0640362 G V mis40--------
    VAR_0640354
    Hyperoxaluria primary 3 (HP3)4--see VAR_0640352 C G mis40--------
    rs1382072571,2
    Cpathogenic199732981(+) CCCAGG/TGCTGA 4 G V mis11Minor allele frequency- T:0.00NA 4552
    rs1133672191,2
    C--92991111(+) GTCTC-/AAAAAA 2 -- int11Minor allele frequency- A:0.00CSA 2
    rs568974791,2
    C--99351549(+) TTTTT-/TCTTTT 2 -- int10--------
    rs710073541,2
    C--99353926(-) GTCTC-/A/AA  
            
    AAAAA
    2 -- int11NA 2
    rs118189471,2
    H--99354011(+) cactgC/Gaacct 2 -- int10--------
    rs1132873201,2
    C,F--99354088(+) CCTCCA/GTGCTT 2 -- int12Minor allele frequency- G:0.18WA 120
    rs341866451,2
    C--99356466(+) AAAAAA/-AAAAA 2 -- int12Minor allele frequency- -:0.25NA 4
    rs1123828311,2
    C,F--99362850(+) GCCTCC/TCTGGT 2 -- int13Minor allele frequency- T:0.06WA CSA 121

    HapMap Linkage Disequilibrium report for HOGA1 (99344080 - 99372559 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for HOGA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7509CNV Insertion18451855
    nsv818782CNV Loss17921354

    Human Gene Mutation Database (HGMD): HOGA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing HOGA1
    DNA2.0 Custom Variant and Variant Library Synthesis for HOGA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613597   
    OMIM disorders: 613616  
    UniProtKB/Swiss-Prot: HOGA1_HUMAN, Q86XE5
  • Hyperoxaluria primary 3 (HP3) [MIM:613616]: A disorder phenotypically similar to hyperoxaluria type 1 and
    type 2. It is characterized by increase in urinary oxalate excretion and mild glycolic aciduria. Clinical
    manifestations include calcium oxalate urolithiasis, hematuria, pain, and/or urinary tract infection. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for HOGA1:    
    About MalaCards
    primary hyperoxaluria type 3    primary hyperoxaluria    alzheimer's disease


    Find genes that share disorders with HOGA1           About GenesLikeMe


    Export disorders for HOGA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for HOGA1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with HOGA1)
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    1. Mutations in DHDPSL are responsible for primary hyperoxaluria type III. (PubMed id 20797690)1, 2, 3 Belostotsky R.... Frishberg Y. (Am. J. Hum. Genet. 2010)
    2. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. (PubMed id 21998747)1, 2 Riedel T.J....Lowther W.T. (PLoS ONE 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    6. Novel findings in patients with primary hyperoxaluria type III and implications for advanced molecular testing strategies. (PubMed id 22781098)1 Beck B.B....Hoppe B. (Eur. J. Hum. Genet. 2013)
    7. Purification, crystallization and preliminary crystallographic analysis of human dihydrodipicolinate synthase-like protein (DHDPSL). (PubMed id 22232173)1 Bunker R.D....Baker E.N. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012)
    8. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. (PubMed id 22286219)1 Kettunen J....Ripatti S. (Nat. Genet. 2012)
    9. The enzyme 4-hydroxy-2-oxoglutarate aldolase is deficient in primary hyperoxaluria type 3. (PubMed id 22391140)1 Williams E.L....Rumsby G. (Nephrol. Dial. Transplant. 2012)
    10. Primary hyperoxaluria type III gene HOGA1 (formerly DHDPSL) as a possible risk factor for idiopathic calcium oxalate urolithiasis. (PubMed id 21896830)1 Monico C.G....Milliner D.S. (Clin J Am Soc Nephrol 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 112817 HGNC: 25155 AceView: C10orf65 Ensembl:ENSG00000241935 euGenes: HUgn112817
    ECgene: HOGA1 Kegg: 112817 H-InvDB: HOGA1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for HOGA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for HOGA1 gene:
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