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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRPLL Gene

protein-coding   GIFtS: 50
GCID: GC02M038789

heterogeneous nuclear ribonucleoprotein L-like

 Explore 3 diseases affiliated with
HNRPLL via our new
 Human Malady Compendium 
Biological research products
for HNRPLL
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Heterogeneous Nuclear Ribonucleoprotein L-Like1 2
Stromal RNA-Regulating Factor2 3
SRRF2 3
HnRNPLL1
Stromal RNA Regulating Factor2

External Ids:    HGNC: 251271   Entrez Gene: 929062   Ensembl: ENSG000001438897   OMIM: 6112085   UniProtKB: Q8WVV93   

Export aliases for HNRPLL gene to outside databases

Previous GC identifers: GC02M038703 GC02M038530


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for HNRPLL:
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing
of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et
al., 2008 (PubMed 18669861)).(supplied by OMIM, Aug 2008)

UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9
Function: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including
PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRPLL gene promoter:
         Elk-1   AML1a   GATA-1   POU2F1   POU2F1b   POU2F1a   NF-Y   Pax-4a   CBF(2)   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidHNRPLL promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRPLL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRPLL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22

HNRPLL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRPLL gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M038789:  view genomic region     (about GC identifiers)

Start:
38,789,120 bp from pter      End:
38,830,728 bp from pter
Size:
41,609 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein L-like  
Size: 542 amino acids; 60083 Da
Subunit: Interacts with HNRNPL
Secondary accessions: Q53T80 Q5JB51 Q659B9 Q8IVH5 Q8IVH6 Q96HR5
Alternative splicing: 4 isoforms:  Q8WVV9-1   Q8WVV9-2   Q8WVV9-3   Q8WVV9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for HNRPLL: NX_Q8WVV9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WVV9

  • HNRPLL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136122.1  NP_612403.2  

    ENSEMBL proteins: 
     ENSP00000390625   ENSP00000387088   ENSP00000272249   ENSP00000386575   ENSP00000395289  
     ENSP00000415766   ENSP00000386695   ENSP00000396669   ENSP00000368195   ENSP00000351136  

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    Uscn Proteins for HNRPLL

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0030529ribonucleoprotein complex IEA--


    HNRPLL for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    HNRPLL for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006536 HnRNP-L_PTB
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q8WVV9

    ProtoNet protein and cluster: Q8WVV9

    2 Blocks protein families:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB000634 Serine/threonine dehydratase


    UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9
    Function: RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including
    PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC
    Induction: Up-regulated in stimulated T-cells

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    hsa-miR-3163 hsa-miR-522 hsa-miR-20b* hsa-miR-224* hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidHNRPLL 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0003729mRNA binding IDA18669861
    GO:0005515protein binding IPI18669861


    HNRPLL for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Hnrpll):
     cellular  hematopoietic system  immune system 

    HNRPLL for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Translational Control
    Translational Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for HNRPLL
        Translational Control



    HNRPLL for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for HNRPLL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for HNRPLL (Q8WVV92, 3 ENSP000003870884) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBP1Q153652, 3, ENSP000003055564MINT-2877982 I2D: score=3 STRING: ENSP00000305556
    DDX39BQ138382, 3, ENSP000003794754MINT-62644 MINT-62818 MINT-62742 I2D: score=4 STRING: ENSP00000379475
    HDAC5Q9UQL63, ENSP000002259834I2D: score=1 STRING: ENSP00000225983
    MDFIQ997503I2D: score=1 
    PSMA3P257883I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006397mRNA processing IEA--
    GO:0033120positive regulation of RNA splicing IDA18669861


    HNRPLL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNRPLL
    Search CenterWatch for drugs/clinical trials and news about HNRPLL / HNRLL 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for HNRPLL gene (2 alternative transcripts): 
    NM_001142650.1  NM_138394.3  

    Unigene Cluster for HNRPLL:

    Heterogeneous nuclear ribonucleoprotein L-like
    Hs.445497  [show with all ESTs]
    Unigene Representative Sequence: NM_138394
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000449105(uc021vgc.1) ENST00000409636(uc002rqv.3 uc021vgb.1)
    ENST00000272249 ENST00000409328 ENST00000417371 ENST00000441689 ENST00000410076
    ENST00000488099 ENST00000425682 ENST00000498516 ENST00000378915 ENST00000358367


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    hsa-miR-3163 hsa-miR-522 hsa-miR-20b* hsa-miR-224* hsa-miR-570
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    Inhib. RNA
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    Additional cDNA sequence: 

    AK000155.1 AK291462.1 AK292259.1 AY236962.1 AY236963.2 BC008217.1 BC017480.1 

    15 DOTS entries:

    DT.70104861  DT.110432  DT.100683025  DT.103034  DT.65288472  DT.121023877  DT.100786371  DT.97787144 
    DT.100786372  DT.121023905  DT.40118337  DT.40118338  DT.91745571  DT.99941332  DT.75200159 

    24/170 AceView cDNA sequences (see all 170):

    BE858611 BU154725 AK000155 AI302235 AI884490 AA600090 AI307220 BE328148 
    CB529631 NM_138394 BM718873 BQ028353 AL512692 BM739494 BG572616 AA788594 
    BQ722427 CF528697 BM981493 AA759359 AI638152 AI655053 AI475191 CA395569 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for HNRPLL    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                    -                                         -     -                                             
    SP2:                    -                             -           -     -                                             
    SP3:                                                              -                                                   
    SP4:                    -                                                                                             
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for HNRPLL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRPLL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGCCTTGCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See HNRPLL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRPLL

    SOURCE GeneReport for Unigene cluster: Hs.445497

    UniProtKB/Swiss-Prot: HNRLL_HUMAN, Q8WVV9
    Tissue specificity: Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas,
    kidney and lung

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRPLL gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves HNRPLL1 heterogeneous nuclear ribonucleoprotein L-like 84.62(n)
    97.7(a)
      416702  XM_414998.3  XP_414998.3 
    lizard
    (Anolis carolinensis)
    Reptilia HNRPLL6
    --
    84(a)
    1 ↔ 1
    1(254075161-254093760)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01100304.16
    --
    69(a)
    1 ↔ 1
    11(46495282-46499667)
    fruit fly
    (Drosophila melanogaster)
    Insecta sm6
    smooth
    31(a)
    1 → many
    2R(15405369-15519013)
    worm
    (Caenorhabditis elegans)
    Secernentea C44B7.26
    Protein C44B7.2, isoform a
    29(a)
    1 → many
    II(6898636-6901748)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PTB36
    polypyrimidine tract-binding protein 3
    30(a)
    1 → many
    1(16275108-16278624)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    polypyrimidine tract-binding protein, putative, ex...
    polypyrimidine tract-binding protein, putative, ex...
    28(a)
    28(a)
    many ↔ many
    many ↔ many
    1(37579409-37584185)
    5(21352461-21358180)


    ENSEMBL Gene Tree for HNRPLL (if available)
    TreeFam Gene Tree for HNRPLL (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRPLL gene
    PTBP12  PTBP32  PTBP22  HNRNPL2  
    1 SIMAP similar gene for HNRPLL using alignment to 9 protein entries:     HNRLL_HUMAN (see all proteins):
    HNRNPL

    HNRPLL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/831 NCBI SNPs in HNRPLL are shown (see all 831    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1831602521,2
    --38789954(+) TTCCAC/TCTAAA 2 -- int10--------
    rs1383154871,2
    --38789992(+) AAATGC/TCTGCC 2 -- int10--------
    rs101714131,2
    C,F,--38790118(+) TGTCAA/GCTACT 2 -- int11Minor allele frequency- G:0.04WA 118
    rs777917011,2
    --38790122(+) AACTAT/CTGATA 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1887932961,2
    --38790175(+) AAGATA/GAAAAC 2 -- int10--------
    rs1929351861,2
    --38790257(+) ATACCA/CTGTTT 2 -- int10--------
    rs2017169921,2
    --38790270(+) TCCTT-/AAATCT 2 -- int10--------
    rs1471035961,2
    --38790306(+) AAAAG-/AAAAAA 2 -- int10--------
    rs1443368991,2
    --38790436(+) ACATAA/TTACTG 2 -- ut310--------
    rs1177723511,2
    F,--38790450(+) GATCCA/TAGAGT 2 -- ut311Minor allele frequency- T:0.02EA 120

    HapMap Linkage Disequilibrium report for HNRPLL (38789120 - 38830728 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for HNRPLL
         1 CNV: 32298

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    HNRPLL for disorders           About GeneDecksing

    OMIM gene information: 611208    OMIM disorders: --

    3 diseases for HNRPLL:    About MalaCards
    t cell deficiency    ataxia    malaria

    1 disease from the University of Copenhagen DISEASES database for HNRPLL:
    T cell deficiency

    Export disorders for HNRPLL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRPLL gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with HNRPLL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternatively spliced isoforms of a novel stromal RNA regulating factor. (PubMed id 15256261)1, 2, 9 Shur I.... Benayahu D. (2004)
    2. Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL. (PubMed id 18669861)1, 2, 9 Oberdoerffer S....Rao A. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    6. Proteomic dissection of the von Hippel-Lindau (VHL) i nteractome. (PubMed id 21942715)1 Lai Y....Shiio Y. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Proteomic analysis of the 20S proteasome (PSMA3)-inte racting proteins reveals a functional link between the proteasome and mRNA meta bolism. (PubMed id 22079093)1 Fedorova O.A....Barlev N.A. (2011)
    10. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. (PubMed id 21081666)1 Greco T.M....Cristea I.M. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92906 HGNC: 25127 AceView: LOC92906 Ensembl:ENSG00000143889 euGenes: HUgn92906
    ECgene: HNRPLL H-InvDB: HNRPLL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRPLL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for HNRPLL gene:
    Search GeneIP for patents involving HNRPLL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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