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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

HNRPDL Gene

protein-coding   GIFtS: 56
GCID: GC04M083343

heterogeneous nuclear ribonucleoprotein D-like
 Explore 27 diseases affiliated with
HNRPDL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for HNRPDL    

Aliases
for HNRPDL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Heterogeneous Nuclear Ribonucleoprotein D-Like1 2     HnRNP DL2 3
JKTBP1 2 3 5     JKT41-Binding Protein2 3
LaAUF11     HNRNP2
Protein LaAUF12 3     JKTBP22
AU-Rich Element RNA-Binding Factor2 3     A+U-Rich Element RNA Binding Factor2
HnRNP D-Like2 3     

External Ids:    HGNC: 50371   Entrez Gene: 99872   Ensembl: ENSG000001527957   OMIM: 6071375   UniProtKB: O149793   
ORGUL members:         
NONCODE:n405968    

Export aliases for HNRPDL gene to outside databases

Previous GC identifers: GC04M083268 GC04M083638 GC04M083737 GC04M083802 GC04M083701 GC04M083563 GC04M079085


Summaries
for HNRPDL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for HNRPDL:
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The
hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated
with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and
transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the
cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two
RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One
of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The
protein isoforms encoded by this gene are similar to its family member HNRPD. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979
Function: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in
differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the
transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA
molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs.
Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA
homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence

Gene Wiki entry for HNRPDL


Genomic Views
for HNRPDL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the HNRPDL gene promoter:
         E2F-3a   HFH-3   E2F-1   E2F   p300   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: HNRPDL promoter sequence
   Search SABiosciences Chromatin IP Primers for HNRPDL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat HNRPDL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.22   Ensembl cytogenetic band:  4q21.22   HGNC cytogenetic band: 4q21.22

HNRPDL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
HNRPDL gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M083343:  view genomic region     (about GC identifiers)

Start:
 83,343,717 bp from pter      End:
 83,351,378 bp from pter
Size:
 7,662 bases      Orientation:
 minus strand

Proteins
for HNRPDL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979 (See protein sequence)
Recommended Name: Heterogeneous nuclear ribonucleoprotein D-like  
Size: 420 amino acids; 46438 Da
Subunit: Interacts with ZNF148 (By similarity). Interacts with TNPO1
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent
manner
Sequence caution: Sequence=BAA22860.1; Type=Erroneous initiation;
Secondary accessions: Q6SPF2 Q7KZ74 Q7KZ75 Q96IM0 Q96S43
Alternative splicing: 3 isoforms:  O14979-1   O14979-2   O14979-3   

Explore the universe of human proteins at neXtProt for HNRPDL: NX_O14979

Post-translational modifications:

  • Dimethylation of Arg-408 is probably of the asymmetric type1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O14979

    • HNRPDL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001193929.1  NP_112740.1  

    ENSEMBL proteins: 
     ENSP00000295470   ENSP00000422040   ENSP00000338552  

    Human Recombinant Protein Products: 
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    Novus Biologicals HNRPDL Protein
    Novus Biologicals HNRPDL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for HNRPDL

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005681spliceosomal complex NAS9538234
    GO:0005737cytoplasm IEA--
    GO:0030530heterogeneous nuclear ribonucleoprotein complex ----


    HNRPDL for ontologies           About GeneDecksing



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    Uscn Antibodies for HNRPDL
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    Uscn ELISAs and CLIAs for HNRPDL

    Protein Domains /
    Families
    for HNRPDL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HNRPDL for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry O14979

    ProtoNet protein and cluster: O14979

    UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Function
    for HNRPDL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979
    Function: Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in
    differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the
    transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA
    molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs.
    Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA
    homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence
    Induction: Up-regulated by 12-O-tetradecanoylphorbol-13-acetate (TPA) in macrophages and retinoic acid (RA) in
    granulocytes (at protein level). Down-regulated by IL4/interleukin-4

         Genatlas biochemistry entry for HNRPDL:
    heterogeneous nuclear ribonucleoprotein D-like,ubiquitous,with two alternative transcripts

    miRNA
    Products:            		miRTarBase miRNAs that target HNRPDL:
    hsa-mir-98 (MIRT004948), hsa-let-7a (MIRT004964), hsa-let-7b (MIRT004954)

    OriGene 3'-UTR Clone: HNRPDL
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRPDL
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRPDL (see all 48):
    hsa-miR-579 hsa-miR-548j hsa-let-7a-2* hsa-miR-624* hsa-miR-502-3p hsa-miR-1304 hsa-miR-629* hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: HNRPDL 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRPDL (see all 7)
    OriGene shRNA RFP: HNRPDL
    OriGene siRNA: HNRPDL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRPDL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for HNRPDL

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for HNRPDL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRPDL

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003677DNA binding IEA--
    GO:0003690double-stranded DNA binding IDA9538234
    GO:0003697single-stranded DNA binding IDA9538234
    GO:0003723RNA binding IEA--


    HNRPDL for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for HNRPDL:
     Decreased homologous recombina 


    Pathways & Interactions
    for HNRPDL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for HNRPDL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/290 Interacting proteins for HNRPDL (O149792, 3 ENSP000002954704) via UniProtKB, MINT, STRING, and/or I2D (see all 290)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    HGSO149643, ENSP000003312014I2D: score=1 STRING: ENSP00000331201
    ATICP319393, ENSP000002369594I2D: score=2 STRING: ENSP00000236959
    HNRNPA1P096513, ENSP000003418264I2D: score=1 STRING: ENSP00000341826
    KHDRBS2Q5VWX13, ENSP000002811564I2D: score=1 STRING: ENSP00000281156
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006396RNA processing NAS9538234
    GO:0010468regulation of gene expression IDA9538234


    HNRPDL for ontologies           About GeneDecksing



    Drugs & Compounds
    for HNRPDL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    HNRPDL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for HNRPDL
    1 Novoseek chemical compound relationship for HNRPDL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nacl 6.07 1 10793134 (1)

    Search CenterWatch for drugs/clinical trials and news about HNRPDL / HNRDL 

    Transcripts
    for HNRPDL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for HNRPDL gene (3 alternative transcripts): 
    NM_001207000.1  NM_031372.3  NM_005463.2  

    Unigene Clusters for HNRPDL:

    Heterogeneous nuclear ribonucleoprotein D-like
    Hs.527105  [show with all ESTs], Hs.707013  [show with all ESTs]
    Unigene Representative Sequences: NR_003249, AL528230
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295470(uc003hmq.3 uc003hmr.3 uc003hmt.3) ENST00000502762
    ENST00000507721 ENST00000514511 ENST00000349655

    miRNA
    Products:             		 OriGene 3'-UTR Clone: HNRPDL
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat HNRPDL
    8/48 QIAGEN miScript miRNA Assays for microRNAs that regulate HNRPDL (see all 48):
    hsa-miR-579 hsa-miR-548j hsa-let-7a-2* hsa-miR-624* hsa-miR-502-3p hsa-miR-1304 hsa-miR-629* hsa-miR-383
    SwitchGear 3'UTR luciferase reporter plasmid: HNRPDL 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for HNRPDL (see all 7)
    OriGene shRNA RFP: HNRPDL
    OriGene siRNA: HNRPDL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat HNRPDL
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: HNRPDL (NM_031372)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for HNRPDL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat HNRPDL 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat HNRPDL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRPDL

    Additional cDNA sequence: X75683.1 

    24/59 DOTS entries (see all 59):

    DT.100880439  DT.100880438  DT.100842937  DT.92459284  DT.100880422  DT.99955049  DT.95196997  DT.100880441 
    DT.91785518  DT.100679576  DT.100880430  DT.97861063  DT.95096954  DT.91936625  DT.95215271  DT.121220926 
    DT.121220695  DT.95197045  DT.97861051  DT.120509  DT.92042709  DT.100880434  DT.100880442  DT.121220975 

    24/896 AceView cDNA sequences (see all 896):

    AI923448 BU627427 BU616608 AW874590 AL703524 N66747 BQ009996 AW612956 
    AL537852 BM824854 AW268352 AI678838 BG033347 AA311332 AA179598 CR600214 
    BQ440886 AI912369 AI364460 AL571645 BI254386 AU130662 BM673266 BM746717 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for HNRPDL (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c
    SP1:                                                  -     -                 -                                               -     -                     
    SP2:                                                  -     -                 -                                   -           -     -                     
    SP3:                                                  -     -                                                                                             
    SP4:                                                                                                                          -                           
    SP5:        -     -     -     -                       -     -                 -                                                                           


    ECgene alternative splicing isoforms for HNRPDL

    Expression
    for HNRPDL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    HNRPDL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTAAACCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See HNRPDL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for HNRPDL

    SOURCE GeneReport for Unigene clusters: Hs.527105 Hs.707013

    UniProtKB/Swiss-Prot: HNRDL_HUMAN, O14979
    Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen,
    thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric
    adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma
    and urinary bladder carcinoma cells

        SABiosciences Custom PCR Arrays for HNRPDL
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat HNRPDL
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for HNRPDL

    Orthologs
    for HNRPDL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for HNRPDL gene from 6/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves HNRPDL1 heterogeneous nuclear ribonucleoprotein D-like 79.89(n)
    94.33(a)    		   422601  NM_001031142.1  NP_001026313.1 
    lizard
    (Anolis carolinensis)    		 Reptilia HNRPDL6
    		 --
    		 88(a)
    		 1 ↔ 1
    		 5(42901994-42908629)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC533102 similar to heterogeneous nuclear ribonucleoprotein more 77.43(n)    BC045124.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa11d082 Danio rerio cDNA clone MGC66169 IMAGE5601422, complete more 78.63(n)    BC055525.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta sqd3 RNA binding 44(a)     --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G176401 RNA recognition motif-containing protein 50(n)
    38.57(a)    		   838341  NM_101627.1  NP_173208.1 


    ENSEMBL Gene Tree for HNRPDL (if available)
    TreeFam Gene Tree for HNRPDL (if available) 

    Paralogs
    for HNRPDL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for HNRPDL gene
    HNRNPA32  DAZAP12  HNRNPA2B12  HNRNPA1L22  MSI12  HNRNPD2  HNRNPA12  HNRNPA02  
    MSI22  HNRNPAB2  
    10 SIMAP similar genes for HNRPDL using alignment to 1 protein entry:     HNRDL_HUMAN:
    HNRNPD    HNRNPAB    HNRNPA2B1    HNRNPA1    HNRNPA1L2    HNRPA1
    HNRNPA0    HNRNPA3    HNRPA3    MSI2

    HNRPDL for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for HNRPDL
    PGOHUM00000234454 PGOHUM00000240995 PGOHUM00000241649 PGOHUM00000241896 PGOHUM00000241897


    Genomic Variants
    for HNRPDL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing HNRPDL
    DNA2.0 Custom Variant and Variant Library Synthesis for HNRPDL

    Disorders / Diseases
    for HNRPDL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    HNRPDL for disorders           About GeneDecksing

    OMIM gene information: 607137    OMIM disorders: --

    20/27 diseases for HNRPDL (see all 27):    About MalaCards
    mixed connective tissue disease    connective tissue disease    oral squamous cell carcinoma    diverticulitis
    squamous cell carcinoma    lupus erythematosus    rheumatoid arthritis    bladder carcinoma
    myeloid leukemia    colon adenocarcinoma    gastric adenocarcinoma    arthritis
    fibrosarcoma    cervical carcinoma    adenocarcinoma    hepatocellular carcinoma
    carcinoma    alzheimer's disease    cervicitis    retinoblastoma

    1 disease from the University of Copenhagen DISEASES database for HNRPDL:
    Mixed connective tissue disease

    6 Novoseek disease relationships for HNRPDL gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mixed connective tissue disease 55.9 3 12567457 (1), 8843857 (1), 17453722 (1)
    rheumatic diseases 20.5 1 12567457 (1)
    lupus erythematosus systemic 11.4 3 12567457 (1), 8843857 (1), 17453722 (1)
    shock 0 3 8999868 (1), 10212141 (1)
    rheumatoid arthritis 0 3 12567457 (1), 8843857 (1), 17453722 (1)
    tumors 0 2 10632338 (2)

    Human Genome Epidemiology (HuGE) Navigator: HNRPDL (2 documents)

    Export disorders for HNRPDL gene to outside databases

    Publications
    for HNRPDL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for HNRPDL gene, integrated from 9 sources (see all 119):
    (articles sorted by number of sources associating them with HNRPDL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Two forms of expression and genomic structure of the human heterogeneous nuclear ribonucleoprotein D-like JKTBP gene (HNRPDL). (PubMed id 10072754)1, 2, 3, 9 Kamei D.... Yamada M. (1999)
    2. Molecular cloning of the cDNA encoding A + U-rich element RNA binding factor. (PubMed id 9524220)1, 2, 3 Doi A.... Fujita S. (1998)
    3. Regulation of murine cytochrome c oxidase Vb gene expression during myogenesis: YY-1 and heterogeneous nuclear ribonucleoprotein D-like protein (JKTBP1) reciprocally regulate transcription activity by physical interaction with the BERF-1/ZBP-89 factor. (PubMed id 15190078)1, 2 Boopathi E.... Avadhani N.G. (2004)
    4. Identification of the nucleocytoplasmic shuttling sequence of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its interaction with mRNA. (PubMed id 11705999)1, 2 Kawamura H.... Yamada M. (2002)
    5. Cloning and characterization of a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein-like protein and its expression in myeloid leukemia cells. (PubMed id 9538234)1, 2 Tsuchiya N.... Yamada M. (1998)
    6. Interactions of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its domains with high-affinity binding sites. (PubMed id 12406575)2, 9 Kamei D. and Yamada M. (2002)
    7. Overexpression of JKTBP1 induces androgen-independent LNCaP cell proliferation through activation of epidermal growth factor-receptor (EGF-R). (PubMed id 18381662)1, 9 Wu Y.Y....Wei Y.Q. (2008)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)

    External Searches for HNRPDL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing HNRPDL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9987 HGNC: 5037 AceView: HNRPDL Ensembl:ENSG00000152795 euGenes: HUgn9987
    ECgene: HNRPDL H-InvDB: HNRPDL

    Other Databases showing HNRPDL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing HNRPDL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for HNRPDL Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for HNRPDL Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for HNRPDL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for HNRPDL gene:
    Search GeneIP for patents involving HNRPDL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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